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    <name>I2F1K4_9BACT</name>
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    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="7"/>
            <end position="378"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF00999"/>
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        <source>
            <dbReference type="EMBL" id="AFK05807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="45465" checksum="4A20B6A70F20F424" modified="2012-07-11" version="1" precursor="true">MILSISLIVILSIAVLSLFERVRPPGLIGLVSLGIALGPGGMNLIDPSLLSISDEVRLLALIVIFMRAGLGLNRRIIKKIGPLALRLSFLPGLFEGFSIMIMAHFFLKLSLIQGGMLGFIIAAVSHAVVGPEMLRLKERDFGKRNEIPSTILAAASMDDVVAIILFTVFLGIEGGQDVSIGMSFLMIPVEIILGISLGALIGFLFSLLLKRFHIRGTKKVLLILSVAFVFHKLEEVLPVATLLGVMAIGFVLRERLPVTADTIAGKMERIWVVAEIFLFVLVGASVNVRAIGDSWLMGLLVILLGLTFRSAGVLAATLGSQMDLRERLFCMISYLPKATVQAAVGGIPLAMGVAYGDVILSVSVLSILTTAPLGAIGIRLAARRFAKNQLRIHSVFSSTLFLVVCKCKSCSRFVRSLRLSFT</sequence>
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<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K8</accession>
    <name>I2F1K8_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0060</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05811.1"/>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0060"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="167900at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
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    <dbReference type="Pfam" id="PF04909">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="261"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="428" mass="49535" checksum="A077FEA3714F957C" modified="2012-07-11" version="1">MEEYKEILDYIRQVPVIDTHEHLVHSEDLLQGRDDVLQEFLIHYMSSDLISSGLCPEVLAIARDSERDLVYRWKLIEDYWEFCRHTGYARALDDSIREIYGIDGIRGSTIEELGEKFREANRPGHMREILKDLCNIELAIIDPWTGRFECDRSLFRRVWQPQNYIIPMPPEFDIVGWLEETYAVEIRSLNDWLKVFEMELDENISNGIVGLKSVLAYHRPIRFEEVSLDDAATAFRKALEERGRRRPDRNRGLLIPEIVQDYVMHYILSVANERGLFIQFHTGFLEGNRGILSNSNPELLENLFSKYPRVKFDLFHIGYPYWGVTAALAKTYPNVFIDMCWSHIISPVSARNALSDFLDAVPFNKISGFGGDYAIVDAIYGHLKIARENIARVLADKIGDSTLTVSQAVRIAERLLHDNPKEILLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q6</accession>
    <name>I2F1Q6_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05859.1"/>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0110"/>
    <dbReference type="EnsemblBacteria" id="AFK05859">
        <property type="protein sequence ID" value="AFK05859"/>
        <property type="gene ID" value="Theba_0110"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2199">
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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    <dbReference type="Pfam" id="PF00990">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="22739" checksum="F0DFA7068A378B59" modified="2012-07-11" version="1">MTFDQWKEELEKLSNEGPFAIADIDIDKFSLLNKEYGRDCGDRVFEILDKTLKENLPEKLSFVRFGDEFFVYSSEYTLETLFMEMQDLAQTISKLSFECKGKTVRFTVSGAVGEFPRNASTVEKLLNLLSEGVRKAKVTGRAQIIFAPLEKESKMVMKSNYYLRSQLDGLAKLTALLNRTESSLLREALDDLLRKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V2</accession>
    <name>I2F1V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="AFK05905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730069.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0164"/>
    <dbReference type="EnsemblBacteria" id="AFK05905">
        <property type="protein sequence ID" value="AFK05905"/>
        <property type="gene ID" value="Theba_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0164"/>
    <dbReference type="eggNOG" id="COG5012">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495139_0_0_0"/>
    <dbReference type="OrthoDB" id="297563at2"/>
    <dbReference type="Proteomes" id="UP000002881">
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    </dbReference>
    <dbReference type="GO" id="GO:0031419">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="539" mass="59469" checksum="E35C67F4215F514D" modified="2012-07-11" version="1">MKILAGAIGSDIHTAGILNFLNLARNEGYETIYIGSVIGIDKLLDSIEEASPDIVAVSYRLGKESCEQLLRELKVSLENRGIEKRLIFGGTVETAEVAEKSGLFEKVFDGSEMPEEVVMFLRGKTDEKGEVDYPQTLLERIASKKPYPLIRHHIGLETVDATEEAVRKLAESGLLDIISLAPDQNCQQWFFQQENMISSEDGAGGAPFRKREDFERMYAASRTGNYPLMRCYSGTRDLLKFSLLLKETLNNAWAAIPITWYSQLDGRSDRELLEAIRDNQAAIAWNGGKGIPVEINEAHQWALRYCHAAVEVATAYLAAMAAKRLGVQVYVAQYMFNTPPGISPKMDLAKALAKKELIESLEGDDFTVVTMVRPGLMSLPADPDMARGQLVSSVYTAMNIDPDIVHVVAYCEATRRATDVEIIESVKMAKQAINEAIKGLPDFRQDKEIHEHKQYLKSECKVIIEAIEKIKTGELTSPETIYTAVKTGILDAPGLSKMSVAKGAVRAAIIDGQSCAVDEEGKKIDENDRLTALSGANKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W4</accession>
    <name>I2F1W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05917">
        <property type="protein sequence ID" value="AFK05917"/>
        <property type="gene ID" value="Theba_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0177"/>
    <dbReference type="HOGENOM" id="CLU_1935543_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="130" mass="14914" checksum="52357BA6CF241083" modified="2012-07-11" version="1">MKRCRLIAQKNNNKCMILNRIIDQEDRLPALHVLPVQHIFCSSRSEFGKSFTVNLQMSPAEGVTDGDRRQKPVSTLFEMLRDDNSRRLCNSFVGANGCSPEKGPGWNLCLYREKKDLRNWSVHIFALAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F216</accession>
    <name>I2F216_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ORF">Theba_0235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730131.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0235"/>
    <dbReference type="EnsemblBacteria" id="AFK05969">
        <property type="protein sequence ID" value="AFK05969"/>
        <property type="gene ID" value="Theba_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0235"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_5_0_0"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="130" mass="15141" checksum="C0A0D3A130070BC3" modified="2012-07-11" version="1">MSIMGESILDKVVKEIAEIIDEKLGEDIVILDVSKVSNLADYFVVTTANSDPHMDSLREAILQYIEREAVEIIYYDKGKGYNWMVIDGGYFIVHIFSKKGREFYSLEDLWLNATRYTYRDLVKDEDNTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F255</accession>
    <name>I2F255_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730164.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0276"/>
    <dbReference type="EnsemblBacteria" id="AFK06008">
        <property type="protein sequence ID" value="AFK06008"/>
        <property type="gene ID" value="Theba_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0276"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114057_1_0_0"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="140" mass="15635" checksum="30C204DDA043B0B0" modified="2012-07-11" version="1">MEYSARRIGKMAFYAKTPSGHDIHMDANESSGGDGSAPAPMEMVMAALMGCTSMDVVSILSKMKVTDYEYWISANYEHAKEHPKVFTSIELVYHFSGKNLPKDKIEKAVTLSQERYCSVSAMLGKTADMSMRIEYEGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F299</accession>
    <name>I2F299_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730194.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0323"/>
    <dbReference type="EnsemblBacteria" id="AFK06052">
        <property type="protein sequence ID" value="AFK06052"/>
        <property type="gene ID" value="Theba_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0323"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_1_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="35890" checksum="3E903629F20E4278" modified="2012-07-11" version="1" precursor="true">MLKYIVRRLILAIPVLLGVSILAFMIISAAPGDFLDAYRLNPSISREQIAVLESQFGLDQNVFVQYFKWLGNVLTGNFGYSFSYRIPVFELVWRRLGATLLLSISTLIFTWGIGIPLGIYSALHQYSPSDQAFSFLAFIGISIPNFFFALLWLFMAAKTGWFPIGGIISQNFGDLSFFGKIGDYLWHVAGPMVTLGTSGLAGLMRQMRGQLLDQLRQDYVLFARAKGMPEKNVIYKHALRNAINPIVTMFGYALSGLLGGAVLTETVFGWPGMGRLVIEALNAQDLFLVMATLLLSAVLLVIGNLLADLLLAWVDPRIRYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D9</accession>
    <name>I2F2D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730221.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0363"/>
    <dbReference type="EnsemblBacteria" id="AFK06092">
        <property type="protein sequence ID" value="AFK06092"/>
        <property type="gene ID" value="Theba_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0363"/>
    <dbReference type="eggNOG" id="ENOG5032YVC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361628_0_0_0"/>
    <dbReference type="OrthoDB" id="226932at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="773" mass="87172" checksum="6E3F3E5B6FA61D6A" modified="2012-07-11" version="1" precursor="true">MPKRLLSVIVFLAIVILSFSFSQKVIIEDFKAYVEDYNKEEPSLPKVLKLIEDLDYLSVYRLYKLQMVGSIEKKESSTTIAGLLTRHIEAFDESEFRDIDDRIAYSAFLAWVLTDISGKPFEIHTLNEMPAYLEVFNTYSSRVREMAGEVYKEWIAYSLGLIETKPGLFPDELLVTDSFSSYSIEADAPYDSEKEILSLSNRSVIDALNSAISTISNREYSVSSLVDEEVNRLAVQTAMDLSQVGNAEIMSSGRELFRLWLLRSIGLIDKAPFYPESVEVRVKDIPGFEIDSIPEDSYFQDLMDILEENQELRSQIVEKIQMGAQLLSLKQFTPTSLIESDIESEVRKIVPIQANIMGGIRNELSKSLVSSIDKRIDLWWLRVLAYALIAILGFTVVPAMRKYVIGIIIILETLYIFFIGEITTGIFDLSLHSVVALPAFAFVFILAVAAAFNRRKRSRILILKLLLLFLIALLPFMNLLNEQPELLMDNFEGFYDSVYYSTLKNDVFLAPESMISLQTRDLNSLVSSELNSFKRVLRVIIPNKMNSFSTAAEMSFSVDSNGRLRVAAPAFSEYMSIENQNTYVSELEGLTKDIEGFIRDSERNRKGYEAALSTLIDTSERIVSFAGSRMREDFSNSLETELQSKPELEVALDDYREKMAPLLNDAPSSVPVKVYRVPEFASLVVALLLLSITLFVVRKPVISFINLAVITAYFLIVLPGIDTLNLFVQGGSPMLRISIEPSVNALFLIVFAGIIALSVLWILLSHKKGSVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G8</accession>
    <name>I2F2G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein, snRNP like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730240.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0393"/>
    <dbReference type="EnsemblBacteria" id="AFK06121">
        <property type="protein sequence ID" value="AFK06121"/>
        <property type="gene ID" value="Theba_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0393"/>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022481_2_1_0"/>
    <dbReference type="OrthoDB" id="713667at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="1">
        <location>
            <begin position="451"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="562" mass="64541" checksum="0E542A6F642CC56C" modified="2012-07-11" version="1" precursor="true">MVFDGLILQRVLAEISDVSGQQLRQVYQIGRSEFFFKFSKRGIEISLNPSSPYIIESNRNQNSPSIETPFSLFLRRHINGFFLTKIAQLDMDRITRMDFEGRDAFGERNKYSVIAEFIGPGSNIMVLDEEERILQVFREMISSKRTLARNVKYYPPDSPGKSLRNLSKENITLTLLHSGDTLSRAIMKSFTGFSRATAENIVGFLQIEDVVPSSLREERLDEVAEFLMSLSLDTNGRSLFVIDGTKGAEISPIPLDHKGRCEKVGASEAIRRAIKSSGAETEVDRRKQSIIRKIDKSFKRLFKLIDKLETELSEVENYRDFKKYGELITANLYRLRERRETVELEDWETGETVEISLDSRLTPSENAQLFFKYYSKSLRKEIQLKKRLRVLRDEVNYLDQLKEMVSQAESLEDVREFSSELEEAGIKRKEKIDKKRKKRSQKSGPRVFERNGFKFLVGRNNIENDEITKNASRDDIWFHARGIPGAHVILKKAGKEITPEAILYGSLLAAKYSRGRQSGKVEVAHTEVKNVKKPKGAKPGMVTYRKFESITVDLTKEMVGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H2</accession>
    <name>I2F2H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730244.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0397"/>
    <dbReference type="EnsemblBacteria" id="AFK06125">
        <property type="protein sequence ID" value="AFK06125"/>
        <property type="gene ID" value="Theba_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0397"/>
    <dbReference type="HOGENOM" id="CLU_917676_0_0_0"/>
    <dbReference type="OrthoDB" id="2196326at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="303" mass="34455" checksum="C2F8F8BA688364AA" modified="2012-07-11" version="1" precursor="true">MKRAKLFVMLGLFVMLILTFSSCIPKLPIPVLFIQESNREPGKPILIKVENIGTVDVTSYDWKLENKDGDIITTDNLKKKSFDTAVVYLPSAPENSEVKVTVYANFSGGYVSRSENIAYNVKESVLVEVFEKIGASFNEPSSWFSGMSFPSVRVPTFVRYREDYLESAVGFDPFAQRLLLGILPMSASDIFSQGEVFFQNWQSLTKSAYSSSQMTTLFNSAPVSDNWSIRIKPVTFSGWRPTGWKISVENIDRTKDELWLFRARKIDNLATHLVKINSYYTQVLVNSKRQSQYTQTSPFTNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J6</accession>
    <name>I2F2J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0421"/>
    <dbReference type="EnsemblBacteria" id="AFK06149">
        <property type="protein sequence ID" value="AFK06149"/>
        <property type="gene ID" value="Theba_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0421"/>
    <dbReference type="eggNOG" id="COG3481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056349_2_0_0"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="189"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="353" mass="40103" checksum="666048751AF306BF" modified="2012-07-11" version="1">MKLRDIIGNEILSQINADQDKTNRDGFPFVSDLRPGSTVLSVFKVHSKRIQEARDGKKFLLLTLSDKTGAIRAIDWFNAERNDSTLEQGMVVRISGRVAVYEDRIQLNLDSEGIQILQVGQYDYERFMAVTTKDIPRMYDDLLSLVGRMRDDYIRALLKDIFENDKKFIEKFIVSPAASKVHHAYKGGLLEHTMSVAELCEFFATKYGDSVDGDLLVAGALLHDIGKVYEYTITPNGIERTNDGELVGHIAMGIEMVSKAISKIQGFPRYLQTEIKHLLLSHHGEMEWGSPVIPKTTEAIVLHMADDLDSKVAQFREIEEREFNGSTASWSNYDRFLNRRVFMKNRRSGDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K1</accession>
    <name>I2F2K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730269.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0426"/>
    <dbReference type="EnsemblBacteria" id="AFK06154">
        <property type="protein sequence ID" value="AFK06154"/>
        <property type="gene ID" value="Theba_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0426"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_0"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="339" mass="37138" checksum="3C0C2B76151FC287" modified="2012-07-11" version="1">MERAEYAAIALSGDFSPSEMEEIENSGISDTHLFRCRTDLNKVKLKRFQKSFPDVAKILSRFTKFITFKDVQYPEALRNTFEPPSVIFFEGDPGLLNSRNILAIVGSRKADGYGASIAKEYAKSLSEKGITIVSGLAVGIDAQAHIGALEGRGSTIGVLGTGIDVAYPASNRTLIKSVKQKGCVISEFLPGTPPLKQNFPKRNRIISGLARAVFVVQATMRSGSLITARLALENGRDVFAVPGDINRRNSEGTNWLIKNGAKLISECIDIIDEFPEISFEEPQSGNLQSRVLDLLGNGPLTFGELLLMTDFSSKDLIVELTNLQLGGYIFEENGRWNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L0</accession>
    <name>I2F2L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730278.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0436"/>
    <dbReference type="EnsemblBacteria" id="AFK06163">
        <property type="protein sequence ID" value="AFK06163"/>
        <property type="gene ID" value="Theba_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0436"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="288" mass="31804" checksum="487FBF37743ED373" modified="2012-07-11" version="1" precursor="true">MRKNKLIWLTGKIAFWILVIFIFFYMLFPFYWAVNSSLKSEAQLQMTPATFIPVDSDGRFAPTLQNYVAVFNDGTFVRALWNSTIVAGLTTLLALGVGSFAAYAMGKLRFKGKKLTLYLILSLTMFPQITVLSGLYAVINTLNLGARVSLILSYMIFTLPFTTWVLTAFFKELPTEIMQSAWVDGATPFQTFYKILLPLTAPALVTAGLLAFIAAWNEYIFALTFTTIAPEARTIPVAISLFTGSVSRQVPFGEIMAGAVIVTIPVVVLVFIFQRRIVQGLTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M3</accession>
    <name>I2F2M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492056.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0449"/>
    <dbReference type="EnsemblBacteria" id="AFK06176">
        <property type="protein sequence ID" value="AFK06176"/>
        <property type="gene ID" value="Theba_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0449"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="276" mass="29912" checksum="14A68474544364C3" modified="2012-07-11" version="1" precursor="true">MLRVMRRLVSNPIYTISMIMIFVIVLITLFPGLFAPYDPYKMNMDAFMSRPSIDHLFGGDQFGRDVFSRSMYGIQKSVIIASSAIAISAIIGTMLGLLSGYIGGLTDLIIMRIMDSFFAFPSLILALFIIALFGSSMSNLIFAIGLVYVPIFARTVRGATLSLKDTLFVKASKALGKKNISIMLKDILPNISSILIVTFTTNVSTALLTEASLGFLGLGVPPPEPTLGGMVGQGTSYLLSAPWIVLFPGMMIAIIVLSLNILGDGLRDVLDPRINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M4</accession>
    <name>I2F2M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate responsive antiterminator (MRNA-binding)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730291.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0450"/>
    <dbReference type="EnsemblBacteria" id="AFK06177">
        <property type="protein sequence ID" value="AFK06177"/>
        <property type="gene ID" value="Theba_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0450"/>
    <dbReference type="eggNOG" id="COG1954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111516_0_1_0"/>
    <dbReference type="OrthoDB" id="1821118at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006699">
        <property type="entry name" value="GlpP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35787">
        <property type="entry name" value="PTHR35787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04309">
        <property type="entry name" value="G3P_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016897">
        <property type="entry name" value="GlpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="180" mass="19851" checksum="212C15F79331A52D" modified="2012-07-11" version="1">MLKGIIAALWNRKERPESVVPETVFFLNGGLFEIQERIDRFKAAGKKVFVDIDFVSGLSGDEDSVLYLKKSGVDGIITAKLRIFKQAVNAGMHQSLLRFFVLDSRAVEKGIQTIVSNGVRNIEILPGIVAAKVAPKIRVHAPETTIVAAGLIDSVEEIEMLKNHVDGVSTSSTALWTYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T2</accession>
    <name>I2F2T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative small molecule binding protein (Contains 3H domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730342.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06235">
        <property type="protein sequence ID" value="AFK06235"/>
        <property type="gene ID" value="Theba_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0509"/>
    <dbReference type="eggNOG" id="COG1827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108798_0_0_0"/>
    <dbReference type="OrthoDB" id="1652220at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035922">
        <property type="entry name" value="3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004173">
        <property type="entry name" value="3H_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026043">
        <property type="entry name" value="NadR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40068">
        <property type="entry name" value="PTHR40068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02829">
        <property type="entry name" value="3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037847">
        <property type="entry name" value="NiaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75500">
        <property type="entry name" value="SSF75500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="3">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="3H" evidence="2">
        <location>
            <begin position="72"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037847-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="170" mass="19019" checksum="61B514D70B0F2CD4" modified="2012-07-11" version="1">MIEKVERHKYIMNLLEGSSVPVKGQFLADETGVSRQMIVKDIDELRKNGSSIVATTRGYLLSKRRTFRMVVSVKHDEEDIYDELSEIITAGGHVIDVSVIHAVYGELKGKLDLSTIDDLNRFIAALKASNAVPLLSLSKDGVHLHTIEADSQESLERIRSILKRKGYLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U2</accession>
    <name>I2F2U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730352.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0522"/>
    <dbReference type="EnsemblBacteria" id="AFK06245">
        <property type="protein sequence ID" value="AFK06245"/>
        <property type="gene ID" value="Theba_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0522"/>
    <dbReference type="eggNOG" id="ENOG502ZMGB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2288175_0_0_0"/>
    <dbReference type="OrthoDB" id="2194049at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="101" mass="11356" checksum="D81771846F2C0F56" modified="2012-07-11" version="1">MIALAKRIKELGEECGMTFRLVDENGIPYDGDIDFEIPSLILALSRATGSRSSTVVEGVQITALHMDNLREKCYLIVVGEFLEDNSYRLLKTIVESYEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F308</accession>
    <name>I2F308_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730398.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0592"/>
    <dbReference type="EnsemblBacteria" id="AFK06311">
        <property type="protein sequence ID" value="AFK06311"/>
        <property type="gene ID" value="Theba_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0592"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141587_0_0_0"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="13291" checksum="A7214C999C5FD573" modified="2012-07-11" version="1">MNIENSIVFFGTEDLGLTNSFYVSLLGLKLYKDQNSCQIFLTQGGGMIGFCNHLNLDSQRNNSIITLLTNEVDEFYRKLKDAGVTCSEPTVSQEFKIYHFFTKDPNGYRLEIQKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F340</accession>
    <name>I2F340_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730421.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0625"/>
    <dbReference type="EnsemblBacteria" id="AFK06343">
        <property type="protein sequence ID" value="AFK06343"/>
        <property type="gene ID" value="Theba_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0625"/>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077889_0_0_0"/>
    <dbReference type="OrthoDB" id="1160025at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029059">
        <property type="entry name" value="AB_hydrolase_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12695">
        <property type="entry name" value="Abhydrolase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_5" evidence="2">
        <location>
            <begin position="67"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="246" mass="26557" checksum="3805F087A59F25FD" modified="2012-07-11" version="1" precursor="true">MKRGNTYILLIATISLTAVLTLSVLNFLRPYPPSKEAYYSLSSSDEVIYCFKDGTHIFTPAKGSEIGIVFYPGGLVDPVSYAPLLKRIATSGVSCFLVEMPLNLAVLSPNRAENILKDNPEIKRWILAGHSLGGSMAAKFAYDNQGRVDGLILLAAYPGKDTSLSESGIHVLSIYGSNDKVLDIEALESGKALLPEGTTYLTLRGGNHAQFGYYGPQRGDGDALITLLEQQEMTVSAVLSFIDNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F344</accession>
    <name>I2F344_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730425.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06347">
        <property type="protein sequence ID" value="AFK06347"/>
        <property type="gene ID" value="Theba_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0629"/>
    <dbReference type="eggNOG" id="ENOG5032T9V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112863_0_0_0"/>
    <dbReference type="OrthoDB" id="1524212at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="212" mass="23898" checksum="AB92AFA4161B9740" modified="2012-07-11" version="1" precursor="true">MTKRRRTSPALSIGLFLIMAAIIGFVFSLISINRVGQMKAELSQMRRQYDEDLKAIEDDFEAKLASVERLLGSGGTLEQYIVAKNFLSNYAIDLETIITEAQSSSDRPYFRIFVTGTKEVWVGVKKNSADTAYFFQKNLKPGLSQEKFFYFKNPEIETKYTVMVGRDAYVRSGAPENIYLLFFGFGSGKLVKMPSVEITNISEALDLYIPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F348</accession>
    <name>I2F348_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730428.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0633"/>
    <dbReference type="EnsemblBacteria" id="AFK06351">
        <property type="protein sequence ID" value="AFK06351"/>
        <property type="gene ID" value="Theba_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0633"/>
    <dbReference type="HOGENOM" id="CLU_1608891_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="165" mass="18115" checksum="49E1255D2380850A" modified="2012-07-11" version="1" precursor="true">MRKLVVISIITILSVYGFSMAVSAGIGFNLDMSSGALVTPVFIQFSAGIPYLQGTIHAYVFSFDWSSLVVKGFSLPDHTYLGIQTKVTVHKSIYVKGQIFWSLKHITSLIGGERTIAGTPLYTRIGLGSNFSSIELDAGFDGYWQLEPSSTVPFARPYLLVNFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F364</accession>
    <name>I2F364_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3 8">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">comB</name>
        <name evidence="9" type="ORF">Theba_0650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ComB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730443.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0650"/>
    <dbReference type="EnsemblBacteria" id="AFK06367">
        <property type="protein sequence ID" value="AFK06367"/>
        <property type="gene ID" value="Theba_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0650"/>
    <dbReference type="eggNOG" id="COG2045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070028_0_0_0"/>
    <dbReference type="OrthoDB" id="1617556at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00490">
        <property type="entry name" value="ComB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="PTHR37311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="231" mass="25296" checksum="02184B87FDA20564" modified="2012-07-11" version="1">MLLRVNLLPRTIDESTDLAVVIDVLRASSTITTALQLGAEKVIPVSNVRQALEERNRNPEVVLVGEREAMKIPGFDLGNSPVELSESFVKGKEVVMTTTNGTVAALKSRKAKRITVASFLNLESIAKHIEREKGRVEIQCAGSDGEPSLEDTLLAGALVKRLGDVGINDSCWIASFLYESVRIDLKDFISENGVHAKKLLSLGFSEDVSFCAKINLYDLVPLWRNNGFVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F387</accession>
    <name>I2F387_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="8" type="ORF">Theba_0673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492339.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0673"/>
    <dbReference type="EnsemblBacteria" id="AFK06390">
        <property type="protein sequence ID" value="AFK06390"/>
        <property type="gene ID" value="Theba_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0673"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_0"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="7">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="17480" checksum="318993139C5EF6DD" modified="2012-07-11" version="1">MRRRQSEKREVPLDPIYNDAVVTRLINKIMIGGKKSKAEATVYGALEVLSDRTKQPPMEAFKKALSNVKPLLEVRPRRVGGATYQIPFEVPERRAVALAIRWIVTSARAKSGKPLKEKLALELVDAYNGQGNAVKKREDVHKMAEAGKAYAHFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C7</accession>
    <name>I2F3C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretory pathway, component PulF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730488.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0713"/>
    <dbReference type="EnsemblBacteria" id="AFK06430">
        <property type="protein sequence ID" value="AFK06430"/>
        <property type="gene ID" value="Theba_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0713"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_0"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="67"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="269"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="400" mass="43928" checksum="C530312AF75D9589" modified="2012-07-11" version="1" precursor="true">MPEFRYEVINIKGKPEKGKLSANSKLEALQILSSRGFIVSSIKQSSTTRNYTKASLFPASQKEVSIFSRQLATMVSSGVRIRDSLQVLSTQVLFSRRFRKIISRVVLDIEGGMSFSESLEKTGVFEPLFTNLVKAGEAGGVLDESLERVADFYEGMVELQNQVKSAMAYPLFMMVFAVGIVGMISFFILPNLISAFGGNYEPEGTMAILLKMNDILKNHWPILLVLLLALSIGGFFFFKSKYGNIVKETLGKLIPPVRNLRNMTAMERFTRTTAVLVASGVDLPTVLELAGEVSQSPRVMKAVGNAIVSIKGGESINAALERQKVFPPIVVSMVATGEETGKLDEVMFKVANFYHMQVQNALKKLVSLVEPIMILFIGGFIGFLAITIYGAVFAMEQSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I7</accession>
    <name>I2F3I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730544.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0776"/>
    <dbReference type="EnsemblBacteria" id="AFK06490">
        <property type="protein sequence ID" value="AFK06490"/>
        <property type="gene ID" value="Theba_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0776"/>
    <dbReference type="eggNOG" id="ENOG5033D7N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150610_0_0_0"/>
    <dbReference type="OrthoDB" id="1712653at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013433">
        <property type="entry name" value="PHA_gran_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09650">
        <property type="entry name" value="PHA_gran_rgn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="102" mass="11448" checksum="702E368933A3EC1A" modified="2012-07-11" version="1">MKELSVIIEHTLGIEEAIKRLNKKIEELKSEYEGKFALDSTWEDDSLRFRLKAAGMKTEGSVKFADSTVTLSGKLPLTLAAFRGRIESTLRAELLKVLCDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J1</accession>
    <name>I2F3J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-superfamily hydrolase, subfamily IIIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730548.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0780"/>
    <dbReference type="EnsemblBacteria" id="AFK06494">
        <property type="protein sequence ID" value="AFK06494"/>
        <property type="gene ID" value="Theba_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0780"/>
    <dbReference type="eggNOG" id="COG2179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791761_0_0_0"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PTHR19288:SF25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="350" mass="40276" checksum="B647188B2B3FB0D4" modified="2012-07-11" version="1">MRILDILDNAVPNEKAENVREIDYERLRKLGYSTILFDYDNTIAVWREPFDMRNKPVIDSLISSGMKVGVVTNGPQSRVKNLKDLFGEDLKVYHSMRKPGTKELRKVLSEMKSRPEKTVIIGDLFFTDIIAGNRMGMYSILVSPLVDISHKWYKRLLGKVTIAAYLVFFFTVGWIFRTGRLATPHLFATTVMDIDFDSLKDSGYRLIIFDFDNTLEKWGATSVSKEKRLLISRVERLGLEVVLISNGKSNRLGKIERELGKTKVISRARKPFTFKAKRVLKDFGIPPYKTVIVGDQLFTDIIMGNLLGAYTVKVEPISDREFFWTKLVRRVESLILSKMRKHPEVEALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M0</accession>
    <name>I2F3M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492507.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0809"/>
    <dbReference type="EnsemblBacteria" id="AFK06523">
        <property type="protein sequence ID" value="AFK06523"/>
        <property type="gene ID" value="Theba_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0809"/>
    <dbReference type="HOGENOM" id="CLU_1978897_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="126" mass="13568" checksum="32E3E6D3F9FA1C58" modified="2012-07-11" version="1" precursor="true">MIWLLLIVPALFFDLGFGDLIPLYPIYLTLLVFLPTRNVAFALSLALLLSWIVGIALSGIGMVIALAIILVISAVAFQDRYRTPSFGALVAAAIGITGVCFAGTGFGVLFPFFATFLILRRLSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N2</accession>
    <name>I2F3N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein Hfq</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hfq</name>
        <name evidence="2" type="ORF">Theba_0821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hfq family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492522.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0821"/>
    <dbReference type="EnsemblBacteria" id="AFK06535">
        <property type="protein sequence ID" value="AFK06535"/>
        <property type="gene ID" value="Theba_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0821"/>
    <dbReference type="eggNOG" id="COG1923">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113688_0_2_0"/>
    <dbReference type="OrthoDB" id="1989988at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01716">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00436">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34772">
        <property type="entry name" value="PTHR34772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02383">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="80" mass="9358" checksum="E7C87CAD7E0ED3C8" modified="2012-07-11" version="1">MAEKFNLQDRFLNLLRVNRIEVKIYLEGGFQTKGMVKSFDNFTVLLEDGQEQTLVYKHAIKMMVPQKYVKLTNTSGKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S4</accession>
    <name>I2F3S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730615.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0867"/>
    <dbReference type="EnsemblBacteria" id="AFK06577">
        <property type="protein sequence ID" value="AFK06577"/>
        <property type="gene ID" value="Theba_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0867"/>
    <dbReference type="HOGENOM" id="CLU_2035312_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="121" mass="13513" checksum="EDB4F33C5AB32CFC" modified="2012-07-11" version="1" precursor="true">MRKTFIMIFLLITIFASLAIARYDLDGTVTVTQVYVHTAGGDYKLDISEICLNLFSRIGIEVLWKEVCLGAEKYGCVLCPFDKVIVFFKDETGLESAAVVAADKDRFAQEFLNGVPTYLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X0</accession>
    <name>I2F3X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0915"/>
    <dbReference type="EnsemblBacteria" id="AFK06623">
        <property type="protein sequence ID" value="AFK06623"/>
        <property type="gene ID" value="Theba_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0915"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064797_0_0_0"/>
    <dbReference type="OrthoDB" id="679278at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="29247" checksum="74B369D7931AD40A" modified="2012-07-11" version="1">MISSAKNIILSTASIIADIISGNWSGVAQQISIEALLDEFVDYVKNDLLDDVLEAVKDKLRAYLSDPSKAEELLSLVKGDMLGWVKDGEDSDEGSVRDEIRQVVYTDLTYRNFTKPVIRELEESLSGAARLASLSISDLDLYAASWSMNRDFASMRSEVMGPLQDWSFEVLGEHERIDNWETILEIFEETVPLIVELLRLMEYKNPVLGDIAEEVSKLSYVLDAVGLLTLAYEVSLKADQLTTMAGKLDRVNDYLFLEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X3</accession>
    <name>I2F3X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730649.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0919"/>
    <dbReference type="EnsemblBacteria" id="AFK06626">
        <property type="protein sequence ID" value="AFK06626"/>
        <property type="gene ID" value="Theba_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0919"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_0"/>
    <dbReference type="OrthoDB" id="1435073at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="37"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="104"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="35921" checksum="383F311C3C4ECDD9" modified="2012-07-11" version="1">MKILFLNRLDRYWEGKVEELARAFPEHSFISYSSDSDPKAHISDAEVIVKGNLSQADLDKARNLRMVVVPWTGVDGLPLERLRERGVIVSNTHENAEVVAERAVALALAVTGRVVELHNDLAQGVWLGRPSNKEATWYSIIGKRCSVLGLGKIGQAIAKLISGFECEITGFKRTSGGEFPYVKRVTDDIHDAVRAGDLVFVALPLTKKTAGIIGSDLLSQMKGKYLVNVSRGRVIEEQALYDALKSGTLAGAAIDVWYEYPSSDRPATLPSRYPIHRFSNVVMSPHVGSWSVESMHSMVNGALKNIESFLLKGRPEEEIDLDELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z2</accession>
    <name>I2F3Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroorotase-like cyclic amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730667.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0939"/>
    <dbReference type="EnsemblBacteria" id="AFK06645">
        <property type="protein sequence ID" value="AFK06645"/>
        <property type="gene ID" value="Theba_0939"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0939"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_2_0_0"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="52"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="460" mass="50878" checksum="97746CA700CAD233" modified="2012-07-11" version="1">MTYDLALENGTVCTENGLFPANVYVEGEEIRVISSIKEKLPAKESIDCSGLFLLPGFIDPHVHLGLALGRYTSADNFESGSSLALSGGVTTLIDFLDPISDLAQLEAAKRDRMTAAKDSRVDYSFHVTLAGNPSFSAEEIARSSIAAKMPSIKVFTTYSSSGRRSNDGMIYSLLSLSRKLGFVLMAHSENDEIIREREKEFSRPTYRDISSLRPTISELSEVAMLSLISLEEEGQLYIVHVSSGKTVEALSSLGLDWRRFTKLETCPQYLLLNNDPLKTDQGYLNTYCPPPRTDQERALLQSALRKGEISSIGTDHCPFLNREKWENRDDYPTIPNGTGSLGISFATINTILDGDLKRVSSLLSTNPARIFGLFPKRGVLAPGSIANIAIVDRDVQSTVSRSRYTRSDHSLFEGIKLRGSVETVIHRGKLAFKNGDILLPKASGRFIERENIYWEKGTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F437</accession>
    <name>I2F437_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730705.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0984"/>
    <dbReference type="EnsemblBacteria" id="AFK06690">
        <property type="protein sequence ID" value="AFK06690"/>
        <property type="gene ID" value="Theba_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0984"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_1_0"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="46"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="299"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="439" mass="49113" checksum="A03180D650BD1E33" modified="2012-07-11" version="1">MKTYSEAIQYLYNSRPYGKIKFGLFRIRELLERLGNPQKSYPIIHITGTNGKGSVAAITRSIMSSHGLKTGLNISPHITTFRERIQVDGEYISEGDVCRILKNIEPALEKMDRKGEEYAPSFFEVVTAIAFQYFKEESCDVVVLEVGLGGRFDASNVIDSSLVSVVTSVGLDHTGILGDTEEKIAIEKSGIIKLECPVVSGITRPAIRRVVSEKARSMNSPYFFYKRDFDATGREYALNRNIFDYTGSNNFENLQINLNGEHQTVNAALAIKTSEIAMGEIRSGLGEEKLRMALKSVSWPGRFEVFSQDSKSVILDGAHNPDAARVLRRTVEKYFPGERLTLLFGSLDDKDYETNIKVLSEIADSVVVCRVPNHRSIHPEKVADVWRKYCSSVQFVEEHEIAMNKALEISDSLLVCGSLYLVSEIRNLLTGVSEHAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D2</accession>
    <name>I2F4D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06785">
        <property type="protein sequence ID" value="AFK06785"/>
        <property type="gene ID" value="Theba_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1080"/>
    <dbReference type="HOGENOM" id="CLU_2633985_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="8504" checksum="51E95E23E9297F09" modified="2012-07-11" version="1" precursor="true">MTEEEFVGADSTGCQYYSLHVILTMLLVRISVFAVFSRPDPVQKHHGMTERRAVKDLGLGLSEGRVHDLGRGTKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D7</accession>
    <name>I2F4D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730788.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1085"/>
    <dbReference type="EnsemblBacteria" id="AFK06790">
        <property type="protein sequence ID" value="AFK06790"/>
        <property type="gene ID" value="Theba_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1085"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="36527" checksum="6BDFC09C74BAD88A" modified="2012-07-11" version="1">MSHVLEVEDLTVEFRLPEGILRAPDGISFSVGEREVLGIVGESGSGKSVTALSLMGLIPSPPGKVKAAKMEFMGKNLLKEVEEIRGKKISMVFQNPLNSLNPSMKIGAQLIEVLVNHMNMTKPEAKEKSIEIMKNLGIPSPENLMNRYPFEYSGGMRQRIMIAMAMLCNPKLLIADEPTTALDVTIQSQILYMFRELKEEFETSLIFITHDLGVIAQIADRVMVMYAGKQVENASVEDIFKNPKHPYTLGLLDSLPKLIPEKRKQRLLSIQGNVPGLLKPPKGCRFHPRCSKAMKICTEKEPPAFSVGSSTVWCWLYGREVANNEAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J5</accession>
    <name>I2F4J5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1508 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730839.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06848">
        <property type="protein sequence ID" value="AFK06848"/>
        <property type="gene ID" value="Theba_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1147"/>
    <dbReference type="eggNOG" id="COG3422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163886_1_0_0"/>
    <dbReference type="OrthoDB" id="1984963at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1508" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="63" mass="7182" checksum="A525C93602AAE9D8" modified="2012-07-11" version="1">MKEPRFEIFKDKNNEYRFRLLAPNGEIIATGEGYSTKSNCKDGINNVKEYAPIAQIKDLTEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L4</accession>
    <name>I2F4L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">Theba_1169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730856.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1169"/>
    <dbReference type="EnsemblBacteria" id="AFK06867">
        <property type="protein sequence ID" value="AFK06867"/>
        <property type="gene ID" value="Theba_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1169"/>
    <dbReference type="eggNOG" id="COG1089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_0"/>
    <dbReference type="OrthoDB" id="955232at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="6"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="355" mass="40641" checksum="77E01777CD2E7E21" modified="2012-07-11" version="1">MKKHALITGITGQDGSYLAELLLDKGYEIHGIIRRSSSFNTKRIDHLYKDPHERDVNLFLHYGDLTDSTNLIRLIQEIQPDEIYNLAAQSHVKVSFETAEYTANSDGLGTLRLLEAIHFLGLEKKTKFYQASTSELYGKVQETPQKETTPFYPRSPYAAAKLYAYWITVNYREAYGIFGSNGILFNHESPRRGETFVTRKITRAASRISHGLQDRLYLGNMDAKRDWGYAPDYVKAMWLMLQQEEPGDFVIATGETHTVREFVELSFKEAGIDIHWSGTGVEEKGINSKTGKIVVEVDPDYFRPTEVELLLGDPTKARDKLGWQPEVKFKELVEIMMKADLEAAKYEKYKKQYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M2</accession>
    <name>I2F4M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730864.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1177"/>
    <dbReference type="EnsemblBacteria" id="AFK06875">
        <property type="protein sequence ID" value="AFK06875"/>
        <property type="gene ID" value="Theba_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1177"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_36_1_0"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="365" mass="42568" checksum="C18B5E641961BFC2" modified="2012-07-11" version="1">MTRVCVITTVHPPNDIRISKELNTLSKAGYEVIYIAKKGKFENDKITYWPITEYQGRLNRLIKGSREALQKALDANADIYHFHDPELIGLGTKLKHRGKKVVYDIHEEYPSVILSKNWIPKIFRSPIARFTDVYERRAVEQMNGIVVVVPEQLERFPNKKEVAILPNYPETEFLNSMRKNTDEERVRFVYSGSIDVDRSIKEMIDAFFMLNDKYNISLDLLGPIHNEELKEYINHKQKESDALTYRGVLPYNDAIEVVSQCDIGLMVMHRGRSKEMSSPLKMFEYLGLGLPIIASDFKKWHEVLDERPCALFVDSDSAEDIAEKMEILIKDEKLRSQMRDNAIEISRKYTWKSVEDRLLKLYRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S9</accession>
    <name>I2F4S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1244"/>
    <dbReference type="EnsemblBacteria" id="AFK06932">
        <property type="protein sequence ID" value="AFK06932"/>
        <property type="gene ID" value="Theba_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1244"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_3_0_0"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="32976" checksum="DA8BB5710B75283D" modified="2012-07-11" version="1">MLNYIADQWCDEQSSLVSVLCPGVMNSESVYEVVRTYNGLPFAFRKHFERLKQSAALMGLEVPFTCKELNSIIMEGLEKNKGFQTQDFRIRISLMSDGARSRPAIIFSDLPSPSKDIYELGVKISISPFLKPSADIVNPQLKMPGSSWIVRTRKALGDNYDMLILNEKGNVCEGSFSNVFLVKDGSVVTPDIRSGVLPGITRDNVIGLCESLEISVEKRPVPAWELFCAEEIFITHTSVGIVPVRRLEDKVLIEDFTDGMTRLLLDNFEGYIMTEDSNWSGLDEVEPSNYRADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F502</accession>
    <name>I2F502_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730976.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1317"/>
    <dbReference type="EnsemblBacteria" id="AFK07005">
        <property type="protein sequence ID" value="AFK07005"/>
        <property type="gene ID" value="Theba_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1317"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_1_0"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="804" mass="88525" checksum="93399B05868A39BF" modified="2012-07-11" version="1">MKTIKTKTGIGKWLPRKYDLEKAEGTLQFADDLRFGSELLHAAVVRSSVAHGEILNVDDSEALKIPGVLKVLLGEDFPHHFGLYLKDRTPMAIGRARYVGEPVALVVAETEEAASEAAKKVKVTYSELEAIFDPVKAATNNSVLVHPDLHKYEHVDFITPQPNTNIANWFRIRKGDTEAAFKNSAHVFEETITCPQIAHGFIETFCTICKQDPGSGEITIWTSAQSPFTVRDIIAKGINYPLHKIRVIAPPIGGGFGGKAGMTVEALCLAAAMDEDIKGRPVKLFIPREEVMLSSWVRQGFVARIEMAVSDDGLMQGIRNTFWFDTGISAEYGANPVRSAGYTSMGAYNIPNVWADCYAVYTNKPFGGAYRGFGLPELMSALEVVVDIVAHKLKIDPVEFRKKNLIKKGQTTCTGMPMHDHALEKIVDKVVEKMDLHKEEPATRKGWKRGKGIALAIKAPAIPADASSSAIVKLNGDGTVEVLAATMDMGQGTYSAFAQIVSEELGIPYDWIKVYYPDTQSHPYDWQTVASRSCWSMGMAVKRAASELREKLLALFAEYWQTPVETISIEYGVVKCHKLGKSERIDERVQNGFKMPDGILKGGPIIGTGSFTPPDLIYPDPDTGQSSKVVAHFTLGAVGIDIEVDPGTGRILVNKVCAGYDVGKAITPINIKGQIEGGTVQGLSACLMEGLSYDERGRLLNPDFTDYKIATIMDAPTEIESFWEEVPEEISPYGNRGVGEHSMIAPAPALNNALFKATGMRIHSYPLSRERVHKALKAKEKGETDFWEWPYELDLAYMRAKKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F517</accession>
    <name>I2F517_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ORF">Theba_1332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486738.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1332"/>
    <dbReference type="EnsemblBacteria" id="AFK07020">
        <property type="protein sequence ID" value="AFK07020"/>
        <property type="gene ID" value="Theba_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1332"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_0"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="26705" checksum="683BB979098E2B1A" modified="2012-07-11" version="1">MLSAEEEKLIEKFCRINGIEADRELVFRALCHSSFTNELAQNGERTLESNERMEFLGDAVLELSLAKTLYNEYYLTEGEMSKIRAMVGSEKVLSSVAKTMRIGDFIFLGKGERQTGGAERDSILADAFEAVLAAIFLTGGLGVSVEFVQSKLSDYIERAVEGELILDYKTSLQELTQARFGSRPLYETLLDEGPPQEKWFKVGVFLDGSLMGEGEGRTKKAAEQLAAKHALEILKKSGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F546</accession>
    <name>I2F546_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730995.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1361"/>
    <dbReference type="EnsemblBacteria" id="AFK07049">
        <property type="protein sequence ID" value="AFK07049"/>
        <property type="gene ID" value="Theba_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1361"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="274" mass="29833" checksum="965A555D66D8198C" modified="2012-07-11" version="1">MIKIVTDSSCDLPIDTLKEFEIPFAPLNIFVEDQTFKEDIDITPEEFWQSMSKSHELPKTSQPSPADFAGIFEEIQKKGDTPLCITISSKLSGTYQSAVLGAEMTGSKAIVFDSLAGSISHGIQVLIAARMAKSGATVEDILSALRIYRDNVKIIIPLATVENIVKGGRLSKFQGSVVNILNMKIILHGVNGEVKLLKKVRGNKRFRAAIIELIEESAKTGKKIFGITHVNNLEDAKFFSSEIRKRVPDSEVIIGKMGPAIATYAGEGGLILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D2</accession>
    <name>I2F5D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_1449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731075.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1449"/>
    <dbReference type="EnsemblBacteria" id="AFK07135">
        <property type="protein sequence ID" value="AFK07135"/>
        <property type="gene ID" value="Theba_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1449"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_0"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0410">Iron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="649" mass="71244" checksum="9C51A0F14EE737E5" modified="2012-07-11" version="1" precursor="true">MENQADAIESKKIKIALLGNPNVGKTSIFNALTGSRQIVANWPGVTVEKRTGVMKLANHTVDVVDLPGTYTLGATSLDERIARDFLINERPDVALVIGDAVNLERSLYLLLQVLELRGDVVLAVNAIDEARKAGFEIDKHELSKQLGIPVVLTSAVTGEGIEELKNTLIKSARSSSHVHYLFTDEIEASLRNLSDRIKGNASLSAFDQRWLSIKLLERDKEVEKLTGISLDYDYSIEIAETRYKYIKRILSSSVKGKEKIGWNLSEAIDHVMTHKFLGILIFLAIMYIVFQLTFTISGPLSIMIENLLDGVGSVVGGWIAIDWLRSLVVDGVIGGVGAILVFVPNIFILFLALGVLEETGYLPRAAFVIDKLMYAMKLSGRSFISLLLGFGCNVSSIMSTRSISEPKERLVTILVSPFISCSARLPVYVLIAGTFFGVNAGIVVFFLYLLSIVITVLSALLINKLFFKGEPSTLIMELPRYRKPRLTSIMLYTWNKGRHFLEKAGTIILAASIVIWILTYFPTEGTGSFAATIGKALEPLFVPLGYTWEMITSLVFGIAAKEVIVSSLTTFFGNPGVSGTSLDIMRTIISPEIALSFLVFVLLYVPCMPTLAVIKNETGSYKFVFFSAFYSLAVAYAVALIVRVVGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F6</accession>
    <name>I2F5F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltose-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1476"/>
    <dbReference type="EnsemblBacteria" id="AFK07159">
        <property type="protein sequence ID" value="AFK07159"/>
        <property type="gene ID" value="Theba_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1476"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
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        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657621" evidence="4">
        <location>
            <begin position="19"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="396" mass="42777" checksum="8B6FA561167447E7" modified="2012-07-11" version="1" precursor="true">MKKLAAVLLMLFVLLSFAGAQLVIWSSENQIPALEKLAADFESDYGIQVEIQQVNFGDIKPKFLTAAPAGEGPDIIVGAHDWVGELALNGLIEPIPFLPDSDQYYEVALDAFSYGGKLYGVPYTIEAIAIIYNKDLVFEEPKTISELEELALEASDDEVVGLIYTAGDFYHSAPFILGRGGYIFKETADGLDVTDIGLNNEGAIAGGKLIKSWFDKGLIPAGPNYNLMDSLFKDGLAAFIVNGIWATPGYRDAGIDYAILPFSEITFDDGTTPRPFVGVQGFMINAKSKNKLEATEFVVNYIGSFEGQYGMFLGERRGTARADVFSFIEANAGPELYDVLQFSKSASVGTPMPNVPEMASVWGAMADALGLIINGQDTVENAFNSAVEKIKTSIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J5</accession>
    <name>I2F5J5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">Theba_1522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731119.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1522"/>
    <dbReference type="EnsemblBacteria" id="AFK07198">
        <property type="protein sequence ID" value="AFK07198"/>
        <property type="gene ID" value="Theba_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1522"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_2_1_0"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="84"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK07198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="36656" checksum="ED89977EF9B13809" modified="2012-07-11" version="1" precursor="true">MSFTVDFYEESRKNVRKTVILVMVFLVMMIAFGLIIDLVFGILPIFTLVFLAIASIQTLISLTSGKEIVLRSVKARELKANDPEERQLKNIVDELSIAAGMGKPPEVYVIDDDSVINAFATGRKQEDSVICVTSGLLKDLDREETSGVIGHELSHIVNRDILLMTLISALLGAVVIVQLLAFRALITYLRFGAIGAATRSRRSSKKNDNSALAIIAFLAAVAGLGALFSFIGRLSLLAVSRTREYFADARAVELTRNPSGLANALRKIVTSSAKLQTANVATAHLFISDPLKRGINNRTSFFASLWSTHPPIAMRISILENKTLTEIEAELSDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N0</accession>
    <name>I2F5N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731142.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1561"/>
    <dbReference type="EnsemblBacteria" id="AFK07233">
        <property type="protein sequence ID" value="AFK07233"/>
        <property type="gene ID" value="Theba_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1561"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_5_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="385"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="617"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="5">
        <location>
            <begin position="738"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="923" mass="104748" checksum="CCF8D20EF8A94D24" modified="2012-07-11" version="1" precursor="true">MRKAFSIVFFMLLSLTLFGQMKYIFSGDVDYPPFEYENERGIPVGFNVDILRAISKALDFEIEIELRTWASARSALESGQIDGLLGMYYSEGRNLLVDFSNPHTILHGSIFYNKRTEGFSSLSDLRESRVAVQKGDLMDELVTSEGVGSEVVRVESPEIALRMLENGEVDAVLMNTLQGLFLIEDLSLKNLMDSEHPVTRLEYCFAVKRGDSELLSLLNEGLSIISSTGEYRQIFNKWFGNINAEDSSGDMLYWLFFAIPVASVVFLVLILMYFWNRTLRRQVKEKTASLSAKLEEERSVKTQLSLSMERYRSMSETISDYYYETEFPSDGKDPEIWRSESYERISGYSLDSPEPREFNWETIIHPEDLDCYKQHLEKVRSGKEERIEYRIIRRDGALRWVSEFSKPKYCGGGSKIKGICGAVRDITDEKLAKEELERTKDKVSKLHFVALKMEKSNEEDTIYHSIIDASVNILGMEKFSLYLLYDQELVTLESQGEVASVQGYLFRSGVLRDCVETGKSAFIESSSIRKVVPNCKDSVSIVPMKSIGALVSYHDSPMKQEEIKMVETLMAHAVEAIWRIRSDREIHYVTFHDQLTALYNRSFFEEEIDRLNVKRQMPISIVMGDVNGLKIVNDAFGHLEGDRLLKAVADCLKSSVRSDDIIARWGGDEFIMLLPQTDAQSAESLVNRIKKALDQVTGFSLPISVSFGIGTKSDIDQDFSETLVSAEEKMYRDKLLNNISMRNKTVEVLERSLLNKSYETEERTERIKTISRDFGKSIGLNEAELDNLLLLGALHDIGKIAVPEEILTKAGSLTAEEWKKIKSHPEAGFRIALSSPELIGIADEILSHHEWWDGSGYPRGLKGESIPLLARIISIIDAYDVMMSGRPYKHPVSSEEAIEELRTCAGKQFDPNLVDSFVSFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P3</accession>
    <name>I2F5P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731153.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1574"/>
    <dbReference type="EnsemblBacteria" id="AFK07246">
        <property type="protein sequence ID" value="AFK07246"/>
        <property type="gene ID" value="Theba_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1574"/>
    <dbReference type="HOGENOM" id="CLU_2070314_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13202" checksum="06A101FCDCA74BA2" modified="2012-07-11" version="1" precursor="true">MKGRLKDISGEVFVVLGTILVALAFFMVFTWGDKAVMMTEITVIKKIDNSSAGNSDYRIISESGEEFTVRNAESQGFYAASKVFRMLEVGRTYQVLVTGRRIPLFSIKRNIIEAIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X3</accession>
    <name>I2F5X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731221.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1664"/>
    <dbReference type="EnsemblBacteria" id="AFK07326">
        <property type="protein sequence ID" value="AFK07326"/>
        <property type="gene ID" value="Theba_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1664"/>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042518_0_0_0"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="351" mass="38488" checksum="86445D7D05CE54A3" modified="2012-07-11" version="1" precursor="true">MLKRGFLLGVFVVLSALMLAGIVGAVAEIDKYGNVHTNIPMEAVVYAAIEAGDLVYVTMGTTTIMVPFVTTYGDVDRGKPLARYSDDHVLLAINYGNFAKTYGLEVGSPVYMGLVEKGAYKDELEIRHLVRSDVREDYASDEIFANFREITLGDIAPGKLYRCSHPSIDDPRAPYASALIEQAGIKTVINLSDSDEELASNLEYSEYYKSISEAGNLINLNMGVDPLADDFAKKLGEGLRFMIAHEPPYLIHCVEGKDRAGIASALLGAIMNAKTDEIYADYVKSYENYYNVVPGTAAYEAVRKIIVDLFVIMNDGNPVDDLNVKSVALDYLTKKAGLSYTEIAAIQDILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Y9</accession>
    <name>I2F5Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1682</name>
        <name evidence="10" type="ORF">Theba_1749</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MesG1.Ag.4.2</strain>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731237.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1682"/>
    <dbReference type="EnsemblBacteria" id="AFK07342">
        <property type="protein sequence ID" value="AFK07342"/>
        <property type="gene ID" value="Theba_1682"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07405">
        <property type="protein sequence ID" value="AFK07405"/>
        <property type="gene ID" value="Theba_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1682"/>
    <dbReference type="KEGG" id="mpg:Theba_1749"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010964_2_1_0"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="276"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="733"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="834" mass="91386" checksum="D3621A9D3110A26C" modified="2012-07-11" version="1" precursor="true">MKRYTELSRKYLSRRLRRTLYTLLGVALAVAFITAIMITFESIEASELQSMENSVGRYHGKVVETSESELMDLKIHVLIEELGIQKIAGTIEFPEERASLFIEEANELTLNLRGKSVKEGRLPERPGEIALDSFSAQLLGITPETGQMVSLDIGGKKRTYEVVGIVSKARQESAMSKAFVEISPEEFSEISEESRVVKNAYFTVEAPNNGIRVAALKVASDLEIRDKTTYNGSLIYFLENLSPVNWPAVVLGLLVAVASMVSIYNTVQISVLERIREFGLLRAAGATPAQIRKVVFRESILVSLVGIPLGLATGVLLSFAIALYAGSQLTGLGGFATMISPLSLLLGAILGFLSVVVSSLIPALRAGKVSPVEAMRQYGVEPSDFEVRGIVKGQSSFGEKIPLKLAKRNMRRNLRTTIISVISMTMAATLFIAFSYFAANFDTERIARGVVKSDFSIRVASMYDDGPDEETIEEILSFEDVQTVAAAKFITGRLLTEWEDRDLDNKSFATFSTPEAGMRATIVDNSGMFMALLAYNDLGIELMKTKVISGSIDLTRATSEPVIIIDIENSNKHGIEAGDRVLLKTYYLNESMVQVPVASEFVVAAVVQELPSVVGYTVEGGILVAACSEKIIEVFRPENGNVHLTMMDYMDHYSYVDIYLRRGSDAEALESTIEEIADRYRNSTFISYSEYKKEAEDAISTLSTLVYGLIAIVGFIGICGITNTMNTTIILRRREFGILRAVGMTGKQLKAMLTYEGLIFGFISAISSVVLGLILSYTVYSLLRSEMSHLNWSIPWMGIVLAVAGAIGAGILTTLASSRKVTSLSITESIRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B0</accession>
    <name>I2F6B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731293.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1812"/>
    <dbReference type="EnsemblBacteria" id="AFK07463">
        <property type="protein sequence ID" value="AFK07463"/>
        <property type="gene ID" value="Theba_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1812"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_0"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="202" mass="22467" checksum="5031C827B702053C" modified="2012-07-11" version="1">MRKALLVVDVQNDFYETGALPVNDASKINTVVNRTMKDPVYKVIVASQDWHPSNHMSFAVNHGKDPFTPFDNGKGIGPVLWPVHCQQGSHGAEFHQDIESWRFDYIVRKGTHPHVDSYSIFKENDGTQLGTDGLLKALGTEELDICGLALDYCLKYTVHDALLAGFKINVIINGTKGVEANQGDIQRTIEEFKSAGVKLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B7</accession>
    <name>I2F6B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731296.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1819"/>
    <dbReference type="EnsemblBacteria" id="AFK07470">
        <property type="protein sequence ID" value="AFK07470"/>
        <property type="gene ID" value="Theba_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1819"/>
    <dbReference type="eggNOG" id="COG2746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060091_0_0_0"/>
    <dbReference type="OrthoDB" id="1018324at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="30401" checksum="77FE00CCF76722CD" modified="2012-07-11" version="1">MSEAEAVKLSNNGPVTTKSLISSLKQLGVKRGMVLLVHSSLSRLGWVCGGAVAVVKALETILDEDGTLVMPAHSGDLSEPSNWTNPPVPESWFDPIRRTMPPFNRVETPTRGMGVIPETFRKMKGVIRSDHPQVSFVARGKRASYIVDNHELEFGMGEGSPLARLYDLNAYILLLGVSHRNNSSLHLAEYRADFPSRKLCKDGAPIIENGKRVWREFIDYELETEDFETIGKTFEEAFPTTVNRGVVGYGKAVLIPQVELVDFAVEWMTKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B9</accession>
    <name>I2F6B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADH-flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488410.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1821"/>
    <dbReference type="EnsemblBacteria" id="AFK07472">
        <property type="protein sequence ID" value="AFK07472"/>
        <property type="gene ID" value="Theba_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1821"/>
    <dbReference type="eggNOG" id="COG2910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_5_0"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="23025" checksum="B7AC474A4BBE0475" modified="2012-07-11" version="1">MKIIIFGGTGRVGRVILDRALGENHIVTVFVGDVSKLTVRKENLRIFQGDVFNSQSVRDAIRGQDAIISALGPDNSGSVNDTLAVAMKNIVSGARETEVNKIVTIANSGILQLSPRELRLDSPNYPQYLKKSSREFLDAFEILKTSELDWVVVCPPFMTFSEGNQSYRVSADFLPENGVKISVQDVAEFAFKQLFTSEYSQKRVGIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C6</accession>
    <name>I2F6C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chorismate synthase</fullName>
            <ecNumber evidence="5">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731303.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1828"/>
    <dbReference type="EnsemblBacteria" id="AFK07479">
        <property type="protein sequence ID" value="AFK07479"/>
        <property type="gene ID" value="Theba_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1828"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_0"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="40754" checksum="4FB3AC50DBE14B41" modified="2012-07-11" version="1">MKFTVAGDSHGSGVFGVIEELPSGVSLSIEKIDRQLQRRQKGYGRGQRMKGEEDRAIVKSGLWKDLTTGAPLLIEIENKVSSAEKSVRSIPRPGHSDYAAWTRYKLNDLAVYAERSSARWTAALTAIGSVASQILQELGITLCSSVIAIGKVSCERPTGTEWISRNCGSPVFCHDEIAYREMLKEIDTANELGETLGGRFVVIADGIPAGTGGYGSLFERLDSRIGKHFMAIPSVKGIFIGNPDVSLRGGEYHDKLYIKDGIVFRQTNNAGGIEGGISNGERIVVEASVKPIPSLRRGISSVDLSDLNETKTPYVRSDTTAVPAAAIVGESMLALLLLEAILERFGNGDFCSIKRRVKDESIPHWNDGFGEEHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H0</accession>
    <name>I2F6H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_1873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731329.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1873"/>
    <dbReference type="EnsemblBacteria" id="AFK07523">
        <property type="protein sequence ID" value="AFK07523"/>
        <property type="gene ID" value="Theba_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1873"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_1_2_0"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="14351" checksum="AC61BE23D339DF44" modified="2012-07-11" version="1">MFFITKEFTFDAAHNLTMYHGKCEKLHGHTYKLQVTVAGEKQEEDMVIDFLKMKEIVRDEVLSVLDHSYINDVLSQPTAENIAEWIFNKLAGKIRGNSFELYEVALWETPTSFVRYRERDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H1</accession>
    <name>I2F6H1_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Theba_1874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07524">
        <property type="protein sequence ID" value="AFK07524"/>
        <property type="gene ID" value="Theba_1874"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="32" mass="3600" checksum="A29F6353696B1168" modified="2012-07-11" version="1">MKKGSLKIGKDVQKEIDKARSASIRYGNFFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H6</accession>
    <name>I2F6H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AFK07529"/>
        <property type="gene ID" value="Theba_1879"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="28556" checksum="EAD3BBB011383D59" modified="2012-07-11" version="1">MIGGNMSRIRRLEEISLNSWPAGYTKFLDGWVLRYAGGYTNRSNSVYPIYDGFEPLEQKIEEASRFYKSKGLRTMFKLTADSKPAGLNSVLKEMGFEERDRALVMTRAIGSEPHDLSDADVASRPEEEWLELFFSLNSRARENQAWARKLLSMLLPGSPFIILRKRGIAVGCGFAVIESNHVGLFGIAVRESERRKGYGREITEKLLELGRQRGAETAYLQVDKPNESAISLYSKIGFREEYQYWYRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I9</accession>
    <name>I2F6I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PpiC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731344.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1894"/>
    <dbReference type="EnsemblBacteria" id="AFK07542">
        <property type="protein sequence ID" value="AFK07542"/>
        <property type="gene ID" value="Theba_1894"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1894"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_7_0_0"/>
    <dbReference type="OrthoDB" id="1807504at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658369" description="PpiC domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="177"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="339" mass="38308" checksum="93DF368EE79C8118" modified="2012-07-11" version="1" precursor="true">MKKFIAALILLLITAVALSQTETLSETGIAAEVNGEIITMDTFLSKVLPNYTEISKRIEEVDPLFSEMLLNTEAGQKLLEEYERNSLEALIEETLLIQYAKEVGIEADIEALREVVSKSIMDTLTELQIEKSDADLFYVLKGYIDGLSSYEAKVVRDLAYKEVLSSLYEAVTVNATVTEEEIEQYYLANSSRYAVEEERADMKVLLFDSFSEAYSVWKAASRDANPSSVLDTFPEVQSGSYTREEIEALNPELVKSLFKPTEGELLSSVVTLDNKYAVIYLESYSPAGAKGIEDVREEIQGILISEKKDLFWRIWQEQEFKPFKEEAVIKRYYETGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J5</accession>
    <name>I2F6J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731350.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1900"/>
    <dbReference type="EnsemblBacteria" id="AFK07548">
        <property type="protein sequence ID" value="AFK07548"/>
        <property type="gene ID" value="Theba_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1900"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_3_0"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="230" mass="27039" checksum="630E063E074968A3" modified="2012-07-11" version="1" precursor="true">MEQLELVFSFPEFEGPLDLLVFLVRKHRVDIRSIPITVIADEFITHVNKMKSLDMVVTSDFLVMASTLMEMKSKALLPRMSGGEAETFDNQRKELYRRVEEYKALKDLSKEFRVKLYDAYSYERATAKPTVDQKRKEDLPEELTEAFKAILKETVLRDRVYTIVSESINVEDRMLQIEQLYETIELYKFLMSLESRSEIIVSFLAVLELLKLNRYYLDTVEPLTLRRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L2</accession>
    <name>I2F6L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731367.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1918"/>
    <dbReference type="EnsemblBacteria" id="AFK07565">
        <property type="protein sequence ID" value="AFK07565"/>
        <property type="gene ID" value="Theba_1918"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1918"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2302545_0_0_0"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="100" mass="10988" checksum="A8659E25F0B0F6FD" modified="2012-07-11" version="1">MKSGILEKIDLAFKSVNPRLSKVFLPWTVRNPRYIRGSAKLLEAFKESESLRDSLLKEGLVVPPIMILGITNRCNLKCKGCFASALGNSGREGLPTVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S3</accession>
    <name>I2F6S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1983"/>
    <dbReference type="EnsemblBacteria" id="AFK07626">
        <property type="protein sequence ID" value="AFK07626"/>
        <property type="gene ID" value="Theba_1983"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1983"/>
    <dbReference type="eggNOG" id="COG4870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558723_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657794" evidence="4">
        <location>
            <begin position="21"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="488" mass="54876" checksum="377C9FD217E81FD3" modified="2012-07-11" version="1" precursor="true">MKKILVVLLSVLFLYTFATANVATQVASIEAEINSAISSMNLSWKADLEESFVAKLETANIGDVEVIFEKLNSYIDLPDEVRERFIEYLRLAYIEEMDEFSIQGMTTTDDLMMSTFVLLEPRVVAESSFVRLEPIRDQFIHGSCWSFATVGSFESALAVQSFGMNGNVDNTFDYSERWGTYHNIDWDIYSFSPDSYVQDKNSLEGGNSYFAMYNLIRYGMMEEQYAPFSEVYIDAREEIPLPPSAYDAPLLKSSRTVMIPPSTSAAELGYSYEDYLNMIKTALSDYGSLAVSFSVPYSFNYYSKGIYSPVEGDYSTGGHAVTLVGWASATDLDDIILAGKTNPDATPILDEEIESYTYVDPTQAASPIFTTTTFWIIKNSWAYDWGDGGYFVIPAISEEQYESGQLGFWEIEKREMYLPIFDDLAHHEGDDLDVNSDGVVDTKDFEYLVEKIGSTEADDITACDISFPKDGKINGEDAAAWVFLFNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X2</accession>
    <name>I2F6X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligoendopeptidase, M3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731456.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2032"/>
    <dbReference type="EnsemblBacteria" id="AFK07675">
        <property type="protein sequence ID" value="AFK07675"/>
        <property type="gene ID" value="Theba_2032"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2032"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030403_3_0_0"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="177"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="568" mass="67124" checksum="B67F1B916B23CB37" modified="2012-07-11" version="1">MEEISLKRLQRRYVGSDIDLSLWENLESELKRLEEYEIVDRDSLENFLLHWSELFMILQEKLAWKYIDMTRFADNEKKRLDYSKFFEDVYSKAEPYRIRLMKKYYDSIHRRELDPFRYENFDAIVSNAVELFNEDNLSLEVQEKKMASEYAATIGSITAEFRGKEYTLSQLSRFQLEPDRLTREEAWRLSMSKLDEVHESLENLFDRLLSVRVPQAANSGFSSYRDYMHQKKNRFVYSVEDVHRFHESVEKVVVPFVSELNEKRRKELGLDRLRPWDISVEPSGRVLKPFETMEEFIQKAIRVLQKVDPEFGVNLLKMKENGLLDLENRKGKAPGGYNYPLDETGAPFIFMNATGTPANVKTILHESGHAMHSFATTDEKLIAYRHATHEAAELASMSMELLTMDYWDEYYSEEEVRIARKEELAGTLSFLPWCMIVDSFQQWIYTNPDHSSSERDEKFSLVFDRFNTGVDWTGLEEEKKIRWLLQPHIFTNPFYYIEYGIAQLGALAVYRNYRQNGSKAIKDYKKFLSMGYSRPLDELFESAGIKFDFSEHYLLELVRFVESELALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F700</accession>
    <name>I2F700_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731480.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07703">
        <property type="protein sequence ID" value="AFK07703"/>
        <property type="gene ID" value="Theba_2065"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2065"/>
    <dbReference type="HOGENOM" id="CLU_1794238_0_0_0"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="144" mass="16232" checksum="1CA679F6BB599EE1" modified="2012-07-11" version="1" precursor="true">MERVFFAVLFTIFIVAAAGTLYQEPQVIFASHLQDGTLVYGGSVMLSWDVVVRNNSIILSNLDIWVSNRDSGARVGLESSPLIEIASYNLYLGTSSTPKLYASTGSNSYFVDRLSNDTVYYWQIVAIDKNGNRYYGPIWYFETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F710</accession>
    <name>I2F710_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731490.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2076"/>
    <dbReference type="EnsemblBacteria" id="AFK07713">
        <property type="protein sequence ID" value="AFK07713"/>
        <property type="gene ID" value="Theba_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2076"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463670_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="455"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="588" mass="66760" checksum="1AAC9C9385217AFA" modified="2012-07-11" version="1" precursor="true">MSIPGSKLQVYLTSILIVVVSAVVFSLHSIQPVKFFAILSEMVVIGVSLVAAYLLGNRELHKGIPLGLIFLSVSTYFDLLEALTETRVYEFVSVVLLLIGLPMLLISAFYHIKERKKRISEFGAVVNNSLDGILLLGLSGEILYPNRAACSLLGYSSEELMRKRVSDLLSEDSEKKFEKAKSSLFAGKNAFQIELELITARQFKLVAEVNLVIGRDTKEDPDSFLMTFKDVTHLRKIESTLIEQNKFQRLLNELITEVLESDFDEKTYRYFLMRCVEVFPKADAAAFLLKKEDNRYHFVATHNYDFEKLKTVSFSSEELIQKGSDDVVIIKDYSVDYKMDGERLEKIVKGGRLEEIKSTLSIPIKIDDDIRMYFNLDSFTSSTAFDDKEVVNTAIGFGKAISVLLWRIQTVNELRRQRKLMEKLSMEDHLTGLPNRRAFFDCAERQLEFSKRKSEAMALLYLDLNDFKGVNDTLGHDFGDELLKSVGKRLSTVCRKSDLIARMGGDEFVYVLPSTGKEGSREAETRIHQAFEDPFSVKGRSLKLTASVGIAVFPDDGKTIRELLIVADEKMYENKEKLSRESKRVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F717</accession>
    <name>I2F717_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein containing a von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731497.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2086"/>
    <dbReference type="EnsemblBacteria" id="AFK07720">
        <property type="protein sequence ID" value="AFK07720"/>
        <property type="gene ID" value="Theba_2086"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2086"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011139_2_0_0"/>
    <dbReference type="OrthoDB" id="271104at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="267"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="704" mass="78489" checksum="DA9A5FD9EC61226C" modified="2012-07-11" version="1" precursor="true">MKSLGMIFLFVLAVTSTFSNGVVIPQFPLEQDSGGFVMNTHNVHITVEDGIATVIIEEEFENTSTRLLEAVYLFPIPSSAVISDFTMKIGDQILKGEVLPADEARKIYHEIVAKMKDPALLEYVGTQLIRMSIYPFEPGERRQFFIEYSQPLEISSNSYSMIYPLKIDSFLSAPIGSVSVRISVPLQIAEVYSPTHPFVETTGVSGREYVFIGNDLIPNSDVALVLTSSEDEIPSSLATHWDESTNEGYFLLTLIPRIKEEIVIPKDVVFVLDISGSMYGEKIEQAKRALEQVLQMLRPGDRFAIVTFDGRVHNLTGSLLDASEKAEWIEKVRRIQADGMTNIYGALQTSIDMFSKYDTGRFKALLFLTDGEPTEGITDIGRIISDATPEARARNVHLFSFGVGTGVVAELLDRLVQENAGRVSYIIEGESIEAKVTDLYRSIETPALENVTVSIENLDVKKTLPEGPYSLFSGQALRISGIYFDEGDMRVTVEGTRGGEKYRYEYLFKTSKRSDSPFIERIWAQKRIAHLANLYRYDPSLTEAEKDELKLEIIALSKKFNIINEFTSYLIAPERVQTYTAGDRGGLGAAPPADSVMAAKSVAEMEQDQFVEGGSSDYTFVDGIGFTLEEGVWIQDDEEVNTLESLGLAAYSEAYFELANRSDWVAKVFALGDRIRFIYKGVLIEISDEGIQTLDELLDALNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F748</accession>
    <name>I2F748_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK07751"/>
        <property type="gene ID" value="Theba_2117"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MATE_fam"/>
    </dbReference>
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        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
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        <location>
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            <end position="257"/>
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    </feature>
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        <location>
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            <end position="296"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="372"/>
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    </feature>
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        <location>
            <begin position="384"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="443" mass="48963" checksum="E3494DF44117B7E5" modified="2012-07-11" version="1">MKDFTKRMLSIAVPITLQNLISTGLNLVDNLMIGQLGTTAIASVGLVNQVVFILNILTFGVSSGAGIFVAQFWGKRDEKSIEKTIGHMLYITIGASALFFVLLFFLPERILMIFTTDVEVVKTGAEYARPVAFSTFLTSFSFIIAMALRTVEKARIPMYVSLVALSINTVANYILIFGLGPIEPLGVFGASFATLLSRLVEFVIFVSIVYRKKTPIRLSRSALKFEIPFFRRLMKYATPVIINEFLWSLGITMYSLVMARMGTEFIAARNISSTIENFGFVIFGGLSSATVVMVGAELGRNNFSQAKYNARKLLQLTVITAVATGFIIILLSRFIVNLYNIDQSLKNTVLTVLIIIGLSQPIKMFNAVNIVGVLRSGGDSRAAMIIEIVSLWGVGIPLVAITGLVLKWPLTLVYIAMMVEELFKSILGIRRTLTWKWLKNVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F764</accession>
    <name>I2F764_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AFK07767"/>
        <property type="gene ID" value="Theba_2133"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="558452at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="455" mass="52547" checksum="E3A21ACAF7496718" modified="2012-07-11" version="1">MKFIELIDSVPDYKEFFTVEEMDRRSLELAKRYPGKVKVYEAGKSRGENPIYVLEIGSGKKNALLFGCPHPNEPIGAMMLDFLSERLANDDTFRDQFDYTWHLIKVIDVDGTKLNEGWFKDSSSIRKYAANFYRPPGHEQVEWTFPVDYETLHFHSPLPETQVLMKLIEEKKPEFMYSLHNSGFGGVYYYVSDAVPELYETFSKLPGLFDLPLSLGEPEAPFLEQLEPAVFKLFGMAQEYDYLKKNLGPDKDPADVIKAGTSSDDFASSVADTFSLVCEMPYYYDSRVEDMSEADITRKEAQRFNYQRSVENFEFVSEVMKAVEPYVIDRNSPFYRVFKNVLETYPDQLQAQKNWIENDPSLERKASVAEVFDNKIVSQFYQSLMLGMLRRLLRENDNGSKELAAISKMADEAFERKMEYLENNLNYTAVPIKSLVSVQLIAGLNVADYIQRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F770</accession>
    <name>I2F770_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Na+ efflux pump, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731541.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2139"/>
    <dbReference type="EnsemblBacteria" id="AFK07773">
        <property type="protein sequence ID" value="AFK07773"/>
        <property type="gene ID" value="Theba_2139"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2139"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022118_2_0_0"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="395" mass="43581" checksum="71386B92B8709A97" modified="2012-07-11" version="1" precursor="true">MFRDALIIFRKELKNVFKDPRTIFAVLILPMLIMPVIFLVMNAVSQSQAKTYENAVYSLKVTNLPDERFLKILEGMISFEIVDELNEETVKDFENSIVVEFPPNSAERIENGERIDALVFYNSTSRGSAYGAQMVQNALASYSSFLLSEKLLEHGLTIEDLNPVNVEKMDVAPEESQGTEMLATLIPYFLLIYIFAGAMNIGLDTTAGEKERGSMPVLLVNQVSRSSIATGKILYVMTIAILNSIFTFIGLIIAFKLGGPAFGAENLNLSSLSASTLVGLFITLLTMSGVAAALIVLLGSIARNVKEGSGYVMPIYIMAIVLGIATMQMESPDNPLLYLIPLVNSIFVMKDIITVNFVIARFLLMLISNLAYVSIFIYFLTRVFNSERIMDSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F794</accession>
    <name>I2F794_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2164"/>
    <dbReference type="EnsemblBacteria" id="AFK07797">
        <property type="protein sequence ID" value="AFK07797"/>
        <property type="gene ID" value="Theba_2164"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2164"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053514_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="81"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="28071" checksum="9126DDBA2D4BD3C3" modified="2012-07-11" version="1" precursor="true">MLYLEKSASAILTPPGLFILIFLIIAVILIKKSEERRTKISGVVMIILCFFAYLLSTGFGTHLYLQPLERAYTAPNNVSGQAIVVLSSGIIISPEGQVLDNHSVARLSKAYSLHLQTKLPIIVTGSFMPGRSTVAVSELMRDWLLDRGVASSKVIVEPMAQTTWENARYSADICSQFNWSSIVLVTSAVHMKRAVTSFEKFGLRVTPFPTDYLYDHTKLSFVDFLPNQGALDANLASIHEYFGQLWYLFKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F795</accession>
    <name>I2F795_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane dipeptidase</fullName>
            <ecNumber evidence="3">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731566.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2165"/>
    <dbReference type="EnsemblBacteria" id="AFK07798">
        <property type="protein sequence ID" value="AFK07798"/>
        <property type="gene ID" value="Theba_2165"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2165"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046840_2_0_0"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="430" mass="49347" checksum="D459CD361B997BA1" modified="2012-07-11" version="1">MCDTFVVLGSSTPDGITLFGKNSDREPNEPQAVYFFPRSSNNPDELFTTNQKVDQVSETNAILISKPSWMWGGEMGVNDKGVVIGNEAVFTKERVRRDGLLGMDILRIALERSENAEHAVRIIIGILEKYGQGSNGGFTKTLYYHNSFLVADRESAWIVETSDRFWVTKRVYGSAAISNCLTIETEIDEMHPQVVSNSQDRKWHNPAKEFDFAGSYERRLFRKFSGAEIRLKRMRELIEEKEMNIERCFEILRDHNDRRHQSSMKNICMHAGAGVVTSQTTASMVVAIGDKIEVWVTNSSLPCLSIYKPVWFNSQESSLSFGEGESGLNYWGNWEIFNRLAILRDSKAAELWKEYCLPFEQDLLLSRGKTTEADLTKQAFEKSWKIARKMTSILRGEREEAGFLKKSYWKKQDALLHRLKSRNFRKELPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D1</accession>
    <name>I2F7D1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731596.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2201"/>
    <dbReference type="EnsemblBacteria" id="AFK07834">
        <property type="protein sequence ID" value="AFK07834"/>
        <property type="gene ID" value="Theba_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2201"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_0"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="227" mass="26181" checksum="617062C4DD25C259" modified="2012-07-11" version="1">MAFPVHVAFIMDGNGRWAKKRGLERIEGHRKGAEVADAASHWCADLGIRYVTLYAFSTENWRRPKEEVEFLFELMLLYISSKVGSMLEEGVRMRFMGRLNELPPELGDFVFQIENKTSMGKKLDVIVALNYGGRAEIVDAVNEILKIGKEQISEEDIAMNLYLPDVPEPDLIIRTSGEERLSNFLTWQSVYSELFFTGTLWPDFTKEEFHRAVDDYSKRKRRFGALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F5</accession>
    <name>I2F7F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose-5-phosphate 4-epimerase-like epimerase or aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731617.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2228"/>
    <dbReference type="EnsemblBacteria" id="AFK07858">
        <property type="protein sequence ID" value="AFK07858"/>
        <property type="gene ID" value="Theba_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2228"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_5_0_0"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="229" mass="25788" checksum="06399E4767AE1ED6" modified="2012-07-11" version="1" precursor="true">MLNKLKEEVYKANIAICESGLVKLTWGNASAISREEGLVVIKPSGVDYSVLSPDDMVVVDLEERVVEGRLKPSSDTPTHIFLYRSFREIGGIVHTHSTWATAWAQACRSIPCFGTTHADHFYKEVPCTRFLKAEEVENDYELNTGKIIGETFSTRDYQRTPGVLVAGHAPFTWGKDVKDAVKNSIILEEIAKMACLTLLIKGETQVLPEYIMNKHYFRKHGKDAYYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G1</accession>
    <name>I2F7G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731623.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2234"/>
    <dbReference type="EnsemblBacteria" id="AFK07864">
        <property type="protein sequence ID" value="AFK07864"/>
        <property type="gene ID" value="Theba_2234"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2234"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="292" mass="32249" checksum="A12577248E7DD2C9" modified="2012-07-11" version="1" precursor="true">MTSTVPKNKKKLSKRITAVIVTVLLWAFAAFWFAPIFWMLSTSMKSTAAAVIETPPQWIPQNPTLENYKIIFAPSGGLSLVKATINSIIVAVSSTLATLALSIPAAYALSRLRFRGRMLIFWIYVAVLAFPSVLFLIPHFFIINGMGLSNSYLSLILPGLGGTFGVFLLRQYMLDIPKELEDAAWIDGCTKLRFLISIVIPFVKPAMLVLGLMTFLGSWNSFLWPLLILSKADKFTLPIALIRFSAGWGDPYRGIGPMMAGAFFSVAPSLIIFIVFHRYLMKGISLGSLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H2</accession>
    <name>I2F7H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731634.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2246"/>
    <dbReference type="EnsemblBacteria" id="AFK07875">
        <property type="protein sequence ID" value="AFK07875"/>
        <property type="gene ID" value="Theba_2246"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2246"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="30928" checksum="EE902B0E1F110A3F" modified="2012-07-11" version="1" precursor="true">MIRRRPVTRILVFTVIALALIWTLVPLAWILLSSFKFEADQFSIPPKWFPERLTLQNYAKFFGNSEFVRSLINSVLITFLSTVIALFLGVPAAYALARFNWKHANTIAFVVLIARMTPPIVMVLPFFMIARYLGISNTYLPIVLALSFFSVPFAIWMMRGFFQEIPVSLEEAAMIDGCTRFQSLRRVVLPLVMPGLSATSILCALIAWNEFLFALVLTGQDTRPLPVLVNMFVSERNIEWGVMSAAAIITVLPMIVFGLLVQNDLVRGLTMGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H4</accession>
    <name>I2F7H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731636.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2248"/>
    <dbReference type="EnsemblBacteria" id="AFK07877">
        <property type="protein sequence ID" value="AFK07877"/>
        <property type="gene ID" value="Theba_2248"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2248"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_2_0"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="426" mass="47952" checksum="39B9938C9236B3BE" modified="2012-07-11" version="1" precursor="true">MRTRFMLLLFVLLIASCFAVPLRLSSEVGIHTDAWKTRMEGFTKETGIEVEIQQFPYANYLDQLMLGYTSGRVEIDVPYISMLWYPALSIANYIYPISDIPGYERINETDIPGIRNAKLNGKTYIVPYMNELGGIIYRRDLFEDPVEKANFLNKYGYELLPPQTLEQYRDVAEFFNRPPDLYGVTMMGRRSIFLATHFMQRLWAKGGALLDMNMRPIFNSEAGVEALEEVKYMFQFANPAAMNYDFQEALNEFISGRSAMAEVWTTGMFYVEDESRSSIVGKAGFVGFPRPEEKLGEMLPMLYISWGFSVSSSAPDKEAALEWLLYVTETKNEVEAAPTGNIPARFSALNSPELAESFPWIGDFAAAMENCIPTPIVPLIPEGGSIVSGIIAPAVSEFLAGTKTAEKALDDAVREVDRLMRDGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J8</accession>
    <name>I2F7J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731660.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07901">
        <property type="protein sequence ID" value="AFK07901"/>
        <property type="gene ID" value="Theba_2272"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2272"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_4_0"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="561" mass="64400" checksum="04FA31F80299F7C3" modified="2012-07-11" version="1">MTGKNISCLFEDLGSTGVAVGVFKEGEVILKETFGLANEEQKIPVKTCSIFHIGSVSKQFTAMCIALLEEKSLDVSRRITDFFPDLGSHAAEIRILDLIHMTNGLPDLYKVSQYILGLRESDYLTSTEAYNLLRNLRWLEFEPGKRWAYGNSGYILLGRLVEKVTGSTLNEFAAREIFSPLGMTNTFFREDNTRLIKNVVDGYCEYEYLHSKSFRLPSCEPGRLSKALDLMECTGAGQLWSTIDDLLIWERAFHKKMIGEDPEKLSEKIISPAKLNNGNRCDYGYGLFLTKRKGKTVVMHEGGSLGFNAAIYRIPSESLSVVVLANRNDFLHRMLVKLGIEIYEAIADWVLGEDSACLDSKDEGTKPEELSEDWLEEMKEGDKWFADRKSAQICRLFVEEGFLKLDMNGERVHVLLPLRGLRFEEMDREFEGEIFRENGEKGLLLTNHSGAVWFRPFEKRLSKCDLQEYCGRYYCRDIDTGYDLYATERGLLFSNTNAHHDAMNFEYRPAVKDLFFTYAPPYLSCYFGVEFLRDRDQDVEAFVFRDYDNDGREFLKFAKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L5</accession>
    <name>I2F7L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731673.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2290"/>
    <dbReference type="EnsemblBacteria" id="AFK07918">
        <property type="protein sequence ID" value="AFK07918"/>
        <property type="gene ID" value="Theba_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2290"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="34241" checksum="E945592B3856515D" modified="2012-07-11" version="1" precursor="true">MNYKNLLKRSTANIELFVLLLAAVVLIVVFSILEPRFFSVNNFRILLETMSILGILSLGVNFLLIAGEMDISFTSVLELSAAVVAISSTAHMNTFVSIAFGVLAATAVGLINAFFAVKLKIPSFLVTLGTQVAIGGLVMILCDYRTIIIRDKSFINMFFGRPFANIASAVYWMIGIAIVIWFVLTRTRFGKWVYATGGNPSSARLMGIPTDRVKISLFVTSAILAGIAGFILGSRATSARPAMGTSYLMPAISAPILAGAALTGGQGSAFKTLLAAFVLTIITNGVTLIGLEPAYRDIFMGVILISALSVRYLQNMNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M8</accession>
    <name>I2F7M8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ORF">Theba_2304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731686.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2304"/>
    <dbReference type="EnsemblBacteria" id="AFK07931">
        <property type="protein sequence ID" value="AFK07931"/>
        <property type="gene ID" value="Theba_2304"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2304"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_0_1_0"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="89" mass="10382" checksum="DCFD9C8EFC56F1D0" modified="2012-07-11" version="1">MFILLVYDIGEKRVNKALKICRQYLDWVQNSVFEGELTKAGLETLKKRLGKIMNKEEDSVRIYKLRSEDYLTMEILGIDKKQVADDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S3</accession>
    <name>I2F7S3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731724.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2351"/>
    <dbReference type="EnsemblBacteria" id="AFK07976">
        <property type="protein sequence ID" value="AFK07976"/>
        <property type="gene ID" value="Theba_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2351"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243023_0_0_0"/>
    <dbReference type="OrthoDB" id="1828472at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="532"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1635" mass="175052" checksum="EC8194E7D8CDFA64" modified="2012-07-11" version="1" precursor="true">MKRVLVHILGSVRSWLLIMLLIPFGLLFSENIETPVDNYKPPTEVSGTIAEDTVWTIDRSPYLVRATITISPNVILTIEPGVEVLIVQNQDFIVNGTLRAVGNEENPIVFTGTAQVPGWWRSINIQGEGSAFLEWCEVSFAGASTGAGVLKAGSGSLRLVNSVVRRVMGDGLRISAGYSSFESINNTFMYNTNGVRVGINASYSDQSSTFILNQVDIHLDGGAITGIVKWGASGDYSMTVTGDVSVNAGASLEIAPGTVVKLRQNNRFLVYGQLQARGEEDQQIYFTDLRDDTVGGDANRDSSETIAEEGWWRSINIQNEGSAVLEWCTLAYGGRSDGATLLKSGTGSIRISNSAIVRSSGDGLRVAAGYSLFESSDNYFGYNSVGIRLGINSSFSDFTSRFESNDLDVHLDGGTISSSVVWGASSEYSMVTGGDVVVAAGASLKVMPGTVIKLRQNNRILVYGHLEAAGQESAPIYFTDFRNDLVGGDANRDGEATVPASGWWRSISLLTEGTANFEHCTIGYLGVSDMAGVIKSSTGTFSILNSTIHDVTGDGLRIDNSAGSAEVKYSTLSYNTGAGLYYKTDGVHIEALTISSNGIGIRLPAGCSVEVDEQTYFDGNDIAIQIDPAAISGRVTWGAPSNISILMNGSVSVASGASLTIRPGSVIKIAQNAFLAVDGELMASGTEDNPIFFTETRDNSVGGALSGDGSLPEAGWWRSINIRNEGKAIFDWCTIAYAGRSDGAAILKSGAGSLRISNSVLSHTSGDGLRLSSGYSSFEHFQNEYSYNTIGVRLGINASFADVTTRFEGNSTDIQLDGGAITGTVSWGSDGDYSMVITGDVSISAGASLSILPGTVIKFRQNNRILVYGSLQALGEADLPIYFTDLRDDLVGGDANRDGGETTPAPGWWRSIGIMTDGTATFEHCVIRFAGYGDRSGVLKSSTGAVSMTDTVIEKVAGDGFRADNAAGGVKIGRSTFSENSEAGLNCRTDGVSVEESVFLSNDTGVRTVANASLILDDETYFSENNKDIYVEAATISGSVVWRVPKHLSLLLSGSTSISVGARLEIKPGTVVKMAQNSLITVDGELIALGTGEEPVFFTDYRDDSAGGDSNRDADATLPVKGWWNSINIRESGSAELDFVDIGYSQNGIVRAGSGSFTLTNSNIHDVSGEALKLLSGYSYLELSNNVFLRNGAAVRLATNVSFDDTLAAFEENGTDVYVDGGEINSNVVFGLSSDYSFYISGELTLTKGAVLEIRPGTVLKFAANRGLRISGSLKMLGTEQAPITLTDWRDDSTGGDANHDGDASLPEPGWWRSIYIQEEGSAELEWARIMYAGYGDKAGVFKTGSGSLILRNSVISRIAGDGLLVSSSSGHLEVSGLSFLENSTGVGISSQQTVPLEFVDCVFEGNVVYGIRNDSPVEAVAVDCWWGDISGPHHPSLNNRGTGNPVSDNVSFDPWIGKEELMNESESEEVPSENAQEVVQETVVAEWIEVSSDGLCYEVPSSWFDDSEGYRLELEGDENSKPVSRWFDAEPGSENIFFVIAKVKPEFLEKEEEETRLNMEVVEEFERLIAGEPGIWIELTAAQWNVERSIYSHVYEPGNDGYCLSVGFAAKTGFWTQYEPVLERIMETLRYCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S9</accession>
    <name>I2F7S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2359"/>
    <dbReference type="EnsemblBacteria" id="AFK07982">
        <property type="protein sequence ID" value="AFK07982"/>
        <property type="gene ID" value="Theba_2359"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2359"/>
    <dbReference type="eggNOG" id="COG3090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086356_3_6_0"/>
    <dbReference type="OrthoDB" id="1947990at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="176" mass="20709" checksum="DDE27F7FBD57AFF1" modified="2012-07-11" version="1" precursor="true">MKKIFLSLLKTLQILLNLIESWGGTIFLGLLFLSIFFQVILRYVFSSPSPELFEIAQYSFIWTIFLGAPYARKFDAHIKFDILFLRFSRKVQLILQIVFDLFFCIVLLVSLGPVLGDVIFYKIIKSEVLRIPWTYLFMCFPIFMVLTFIHNVIWIVKSFLELISGKTFAKEVEPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V8</accession>
    <name>I2F7V8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731753.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2393"/>
    <dbReference type="EnsemblBacteria" id="AFK08011">
        <property type="protein sequence ID" value="AFK08011"/>
        <property type="gene ID" value="Theba_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2393"/>
    <dbReference type="eggNOG" id="ENOG5030M0J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608686_0_0_0"/>
    <dbReference type="OrthoDB" id="886332at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="18701" checksum="C328603755C34839" modified="2012-07-11" version="1">MYIRSGDPVRTIIKIVGGIVYVVGIGLIIFSFASFFLAPYLSLVFGGVIVFLVLGFIATTLGRMLLAMAKTKSFSGPVSEQEPVSGRELKEDMTYDYTFVSDREARIEKTKSKSYSRCPECGAENEDNATKCSNCGASLVGYKKCSLCYMLNKKENRFCKNCGHDFTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y6</accession>
    <name>I2F7Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731777.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2424"/>
    <dbReference type="EnsemblBacteria" id="AFK08039">
        <property type="protein sequence ID" value="AFK08039"/>
        <property type="gene ID" value="Theba_2424"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2424"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_2_1_0"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="246" mass="27740" checksum="91EA788E70474079" modified="2012-07-11" version="1">MALKKEDRRQNILSVLSERESINTQELASLMDVSLVTLRRDLRDLQKSGLVINGYGVVRAVNQETDPNSFFLKRLRLAREAKERIAEKAIEFVEENDVLFIDESTTCYVFALKLSRVFKKLHIITNGINILLALSKVQGFSVESSGGSLQYGFDSLIGPRAESLVGSIYANKFFFSCASLRKKIGTFELSPFSASIKRKMLLNSSTKILLVDNSKFDVIAPFKMAEIDEIDRVITEDRDFLPSEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F800</accession>
    <name>I2F800_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731788.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2440"/>
    <dbReference type="EnsemblBacteria" id="AFK08053">
        <property type="protein sequence ID" value="AFK08053"/>
        <property type="gene ID" value="Theba_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2440"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="36661" checksum="ABEEA50D61666111" modified="2012-07-11" version="1" precursor="true">MELRGKLLDVSNLKVSFYTYRGVVKALNGVELWMDSGERLGVVGETGCGKSVTSLAVMRLIEQPGEIQEGKIIFNGRNLVELSEEKMNNIRGVEMSMIFQEPRSSLNPVMKVGYQIGEAIAKSKKIRIKNTYPEVKEMLRLVGLDAERVMNSYPHELSGGMSQRVMIGMALATHPKLLIADEPTSALDVTIQAQILELLDELARKMGNAVMLITHDMGVVAEFCDKVLVMYAGNSVEYASTVRLFEKPLHPYTGGLLQAVPRVGRTDELKAIKGTVPDLVNPPSGCRFHPRCPYAMDICKAERPPFVEIEPDHYVACYLFKGKNEVREDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F812</accession>
    <name>I2F812_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08065">
        <property type="protein sequence ID" value="AFK08065"/>
        <property type="gene ID" value="Theba_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2453"/>
    <dbReference type="HOGENOM" id="CLU_1265706_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="218" mass="25936" checksum="F573586BFD325ACB" modified="2012-07-11" version="1">MFESADKEKIFDWKVALEKTSYGERFYTFSTILDEIGDKTFRHDYYYYNASSLRAEMLKLYPKDSERMPGVEEPSLFLEDMYNYYLRIVSSEQEQMLWLENFMRFLEGLSNKEAFDVFKKHPQIIEDILLQYLALAKIFLDGRESDLWDIDNVYKATTTLAADTELYRNYLFKPLLLFVQSPVFAYLSKKHTDTIICFIIPDYTDIDTAVKIYVELTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F815</accession>
    <name>I2F815_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2456"/>
    <dbReference type="EnsemblBacteria" id="AFK08068">
        <property type="protein sequence ID" value="AFK08068"/>
        <property type="gene ID" value="Theba_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2456"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538398_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658433" description="FGE-sulfatase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="259"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="506" mass="56467" checksum="0F90E382EF7EAB1D" modified="2012-07-11" version="1" precursor="true">MKIAKFLVISILMFATSTLAITETVMPTIQRVLDTERLINADILLLRNGDKLTGTVLNESFSIRTSYAQIALESRYIAGINLEGGATNTEFILTINNNRFSGLIEDAFISFKLTSGQLLEIGHEHVLKIIFRQRPQETAGMKWRQFMKLKDGDYFHGQIITKDITISTAYAKILLDFATTESITLIGDANLLTTVKMTNGDTVQGILETEDIEIALDVGSVIEVHQDRIDRIFFKEGYYVPDSIIPSIVTSTFAPKGNFILVEKNSFTMGDTWGGGDSDERPIHMVTFTYNFYIGKYEVTFDEYDTFCEATGRSKPSDNGWGRENRPVVNVSWNDAIAYCNWLSEKEDLPKAYDSSGNLLDKDGKVTADITKVLGYRLPTEAEWEYAARGGNKSKGYKYSGSNSVDDVAWYDPNSGEMTQEVGKKTPNELGLHDMSGNVWEWCSDWYEAYSNSAQTNPYNTSGSSRVVRGGSWFHFASNARVASRTGSSATGTDRSLGFRIARTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F824</accession>
    <name>I2F824_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine/L-proline transport ATP binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731809.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2466"/>
    <dbReference type="EnsemblBacteria" id="AFK08077">
        <property type="protein sequence ID" value="AFK08077"/>
        <property type="gene ID" value="Theba_2466"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2466"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_2_2_0"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="364" mass="41287" checksum="C753285385CAF2AF" modified="2012-07-11" version="1" precursor="true">MIRFENVTKEYDEETVAVRDITFEIPSRELTVLIGPSGCGKTTTLKMINRIVKPSGGRILIDGEDVKEMDVMSLRRGIGYVIQNVGLFPHMSVKDNIATVPKLLKWEKSKIERRVSELLELVGLEPRSYANKLPKELSGGEAQRVGVARALAADPPIILMDEPFGAVDPLTRVRLQDEFARIQEELHKTIVFVTHDIDEAIRLADRIAVMRAGRILQFDTPEEILARPKEKFVHDFMGSDRALKRLSRIPVTEYIEKCETIDVDGNWDQLGMTKEEFIWALDEERRLVGWVDVSHSNRELPIREALTEMLEEEVLSPDSTVKEALSRMLESGTVALPVVEKSGRFLGQISLAKIQELTRSDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F825</accession>
    <name>I2F825_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type proline/glycine betaine transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2467"/>
    <dbReference type="EnsemblBacteria" id="AFK08078">
        <property type="protein sequence ID" value="AFK08078"/>
        <property type="gene ID" value="Theba_2467"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2467"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_3_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="159"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="373" mass="38966" checksum="E64B2D4399D4FB71" modified="2012-07-11" version="1" precursor="true">MLFSILLPGFLSVKETRISAALPVSLARVSVIGLVVLLAFSGVTILLSFSGYYFLMGLAGGLAPVYGFFLAGSSAIQIASETGPFARVSPSTGLWILLLAGYVVVFAARRKLKDKRILSSLLVLIPIASFAVLLGSGHLRELAIMKEYANRSDRFLEETVRHLLIAGGAVVAGVIIGVPLGVAANSLPKVEKPVFGVVNFIQTIPSIALFGLLIAPLSYLSRSLPFLRELGITGVGWAPAMIALVLYSLLPIVRNTYSSLKVIPADTVEAARAMGMSRLQVLGKVEIPISLPVVLAGVRTAAVQAVGNTTMAALIGAGGLGVFVFQGLGQAAMDLVLLGALPIVALALIVDSLMQLLIAILTPRGLVSEVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F848</accession>
    <name>I2F848_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dissimilatory sulfite reductase (Desulfoviridin), alpha/beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2491"/>
    <dbReference type="EnsemblBacteria" id="AFK08101">
        <property type="protein sequence ID" value="AFK08101"/>
        <property type="gene ID" value="Theba_2491"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2491"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2356470_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="96" mass="9741" checksum="7DF5B862A0AA824E" modified="2012-07-11" version="1">MPWVREDLCTGCTLCLKSCPVDGAIVMQGGKAHINNSLCTRCGDCFSACPVNAIRPNSENSSLRAGGGGYGIGRGAGIGRGRGLGRGMGGGRRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F865</accession>
    <name>I2F865_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731850.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2510"/>
    <dbReference type="EnsemblBacteria" id="AFK08118">
        <property type="protein sequence ID" value="AFK08118"/>
        <property type="gene ID" value="Theba_2510"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2510"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_0"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="36694" checksum="92C70BC70BF616DF" modified="2012-07-11" version="1">MERRKSPIRKYWKQYKWSNIRAMMKNNKSDPKICNDDFEGRLMVITGGTSGIGYYTCRKYASHGARILSINRNREKSERLCDELKRDFGVQCSYMIADFSSLDDILRVGKELSTMGDAIDVLIHNAGVFLKRKELTKEGFETTFVVNYLSSFVINYLIREKMKAQGSGRILIVNSEGHRFAVWGIETEDLNWQKRRYTGLKAYGSAKTCQLLSMLILNQYFEGSGVTINAMHPGAVKTGTGKENGALYKWYKRNVVDRFSRTPEISAEALYYLGVSGDLQDVGGKFFNLTTEEIPAPPALDMETAKKLWQESLRMGGIDDGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F879</accession>
    <name>I2F879_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489546.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08132">
        <property type="protein sequence ID" value="AFK08132"/>
        <property type="gene ID" value="Theba_2528"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2528"/>
    <dbReference type="HOGENOM" id="CLU_191482_0_0_0"/>
    <dbReference type="OrthoDB" id="2043005at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="70" mass="7940" checksum="70B5DF178E8BA5C2" modified="2012-07-11" version="1">MSYKHYYVGDSVLSTGDYEVHTGDCVELARVESKTYLGYYDNCQDAIRKASDIYPNVSGCKYCSPGCHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B2</accession>
    <name>I2F8B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731885.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2565"/>
    <dbReference type="EnsemblBacteria" id="AFK08165">
        <property type="protein sequence ID" value="AFK08165"/>
        <property type="gene ID" value="Theba_2565"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2565"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_0"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="35207" checksum="D6B6AECC0E1176AD" modified="2012-07-11" version="1">MVSIGEFGSKIKENISRVIVGKEKTIERVLAVLISGGHVLINDVPGVGKTMLARSLAISLGLEFNRLQCTPDLLPGDVTGISILNLKTNEFNFRKGPIFTQILLVDEINRTTPRTQSALLEAMAERQVTVDGRSFQMEKPFFVIATQNPVEFEGTFPLPEAQLDRFSISLTMGYPDEQSERKLLKGISDEHPITSLKPVSGQDELDSVLKQVKEVEIEDSVLQYIISIVNETRSHRDIQLGVSPRGSIALMETARALAGIRGRRFVIPDDVKETACDILSHRIIIKPEARLMRRTNRDVINEIVESLPIPINNEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D6</accession>
    <name>I2F8D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731905.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2589"/>
    <dbReference type="EnsemblBacteria" id="AFK08189">
        <property type="protein sequence ID" value="AFK08189"/>
        <property type="gene ID" value="Theba_2589"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2589"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_2_0"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="249" mass="28368" checksum="F48068926F72518A" modified="2012-07-11" version="1">MLFNADRRIALDRASPVPLYYQIYRIISDYMKEPGAVGRKLPTEEAMMKVFDVSRATVRRALQALESSGQISRSRGRGTIITNNASQEQLTTIRSFTEQMRLENHVPITKVVEVKKVKAGSEMARILQVSEDEELLQVTRLRGNESYFPLALFISFLTSRSNLTGEENFEGSLYELMRNRGTAVVEGDAIIEGRLAEGRIAKLLKIEEGAPILYYERVGCTAIGEYVEFVQCWYEATHYKFRIHLTTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G2</accession>
    <name>I2F8G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein, hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731923.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2615"/>
    <dbReference type="EnsemblBacteria" id="AFK08215">
        <property type="protein sequence ID" value="AFK08215"/>
        <property type="gene ID" value="Theba_2615"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2615"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1659567at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="230" mass="25810" checksum="7D74602BE1F8F9DC" modified="2012-07-11" version="1">MNTVEGRRVDPMVSSENSNEGFNAISHILAAVLGLAGLVLLVVFSAIQQKWLHLVSFSIYGTTVVVSMTLSGLLHFFLWFRKYYRIFAILDHSAIYLLIAGTYTPFCLVVVGGWVGWTVFGIIWGLAILNIVLKSVFFSTMPLWVSMAGYLSMGWLSLAMVYSVYIRLGLSAILLLLFGGFFYTVGAVIFIREKPNPFPGKFGNHEIWHIMVMLGNLTFLLMMFIYVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J3</accession>
    <name>I2F8J3_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_2646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2646"/>
    <dbReference type="EnsemblBacteria" id="AFK08246">
        <property type="protein sequence ID" value="AFK08246"/>
        <property type="gene ID" value="Theba_2646"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="entry name" value="Aminotran_1_2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="382" mass="43074" checksum="C7B9C27D0ABEEB1F" modified="2012-07-11" version="1">MKLNDFKLEVYFGKHEFSAPYLLAQSDCEAMTIKELLQMAGDSSSEFLDTWLGYTEVSGNPILRKEISRLYSTVGEEDVLVHSGAEEAIFNFMNVFLQKGDHVICQFPVYQSLYEVANAIGCEITRWELRRSGEEWSFNVDELKDLVRPETKLVVINNPNNPTGYLVPNRDLMKIASFTEERGIFVFSDEVYRGLELDQSVEKQKSFADISDNSLALGVMSKSYGLAGLRIGWVVSHNKSVLESMTRFKHYTTICNSAPSEYLAWKALCVGDKILKRNRAIVVQNWDRAAPFFEKHSSVFRVSRPKAGPIAFVQFVGGDVEDFCSVVLESAGILLLPGSMYDYEGGFFRMGLGRKSFAEGLDRLDEFLDSSNTMITLCDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K0</accession>
    <name>I2F8K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08253">
        <property type="protein sequence ID" value="AFK08253"/>
        <property type="gene ID" value="Theba_2653"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2653"/>
    <dbReference type="HOGENOM" id="CLU_2735349_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="71" mass="7765" checksum="BA75F221CCB01EC3" modified="2012-07-11" version="1">MNPSMSACIIENPREIAFETLGVNGSFHFFLCGFSLGGITTIVDLIADTSLQSTNYPIRQCRKDDIYGGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K1</accession>
    <name>I2F8K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08254">
        <property type="protein sequence ID" value="AFK08254"/>
        <property type="gene ID" value="Theba_2654"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2654"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_0"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="499" mass="55962" checksum="83CC26C83BF23BD3" modified="2012-07-11" version="1">MIGLKIVIDRNSEVPFFKQLVDQLRTAVIRREIPEGTRLPSERELSKLLRLNRSVVVKAYNELKLDGLLVSKTGSGTYVISAHPQKKEFDMISWGEQLNSWATLPAGSARWVNLLKSLSDGCIRLDTGVPHVGADQVDLMKEILGNLTDEELITTLNYPSLRGHPELIKYLCLRMNSSGLHINSRNMLITVGTEEAIYLLFSALARPGETIVIENPTYVNVINISRMFQHRVIPVERNSEGLNLSTLENVLNRSRVKFIYTMSCSHNPTGANMPERKKEALVKLSEQYSVPIIDDTVFSEIQYDLPAPKSLKYYDTHNCVIEIGGISKAYAPGLRIGWIIADEALIERLIEPVRMISLGVPNFSQLVAAKMLSTGEYDAFLKRYLELCLKKRETTKRACYRHLPGYIRVNEAQGGNFFWLELPGSMDGWKLAEEGIEQGVAVAPGSLFTFDSSGRSFVRLNPLGVPHDQIEEGISRLSRAIESNSKRDNREEGTVSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q0</accession>
    <name>I2F8Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08303">
        <property type="protein sequence ID" value="AFK08303"/>
        <property type="gene ID" value="Theba_2704"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2704"/>
    <dbReference type="HOGENOM" id="CLU_3292252_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="40" mass="4385" checksum="F022668CDA9308E0" modified="2012-07-11" version="1">MPGLDIVELENLVVKRVTEPVSDNGEVRYSKEKGVGGRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q7</accession>
    <name>I2F8Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate/sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732003.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2712"/>
    <dbReference type="EnsemblBacteria" id="AFK08310">
        <property type="protein sequence ID" value="AFK08310"/>
        <property type="gene ID" value="Theba_2712"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2712"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_0_1_0"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="311" mass="32083" checksum="B04AF8F3DDDE5981" modified="2012-07-11" version="1" precursor="true">MFFAIIPAVVFGWALGANDAANVYGTAVTSGLVKYRVAVVLSAIFIVIGALLEGSRGLETISSVSSQTLLTASVSTIGAALSMTIMTYLGIPSSSSQAMMGAILGIGILNSTVDWSVLTKVVICWIVTPIGAAIGSFFLYKLSAILFRRIKTIQAQDLSLKIGALIIGAYGSYALGANNVANVTGPLAGIIPYETAALVGGLSIALGVLTFSKRVMLTVGKQITLLDHFSAVIAVLSQAITVWVFAVIGVPVSTSQAIVGAVIGAGLARGSSDINFKILRNIALGWLQTPLIAGFVSLGLYLIVNAVKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q8</accession>
    <name>I2F8Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2713"/>
    <dbReference type="EnsemblBacteria" id="AFK08311">
        <property type="protein sequence ID" value="AFK08311"/>
        <property type="gene ID" value="Theba_2713"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2713"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_3_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="248" mass="28228" checksum="24CB6A30D118799D" modified="2012-07-11" version="1">MVFACVIAYVFLIEPNILTVERLTFSDDPSVKIAFFADIHIWTKKPLHDRILEKFADEGVDLILFGGDVLAPYTDMEYMESFLSELTAIAPVYAVYGNWEESETTTMQKVYEEAGINVVHANSAKIQISDKKLGLTGTPSHHYFSWTKFLPEDDYDLKILMVHAPNLLEEREDVLKDFDLVLAGHTHGGQFYIPWLTEAILKSTRRFSGDFFRGLYQINGTKVFVTRGVGGWFPGRLASLPELVFIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S4</accession>
    <name>I2F8S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732020.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2733"/>
    <dbReference type="EnsemblBacteria" id="AFK08327">
        <property type="protein sequence ID" value="AFK08327"/>
        <property type="gene ID" value="Theba_2733"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2733"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_0"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="9"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="380" mass="41567" checksum="C4C09DE49330DB88" modified="2012-07-11" version="1">MAKMIKKNYLLAPGPTPVPVDVLLEGAKDTIHHRTPQFKKIFEDAVNGTKEVFRTRNDLFILASSGTGAMEMAVANIVNPGEKLIVCSVGKFGERWVELAKTFGAEIVLVERDYGDFYTPEMVERALDENPDAVAVLTTLSETSTGTVMDIEGISKVVKKAGKLIAVDGISGLVAERLLTDDWGLDIVVSGSQKGFMLPPGLAFISFSKEAIEKSKNVSSTSFYFNLKKYLKDPIPWTPAVNLIYQQSLAVKMLLEEGMENVWARHELMGKATREAIKAMGLELFSKRPGNVLTSVKVPEGVDGGKIVSIMRDEYGVTIAGGQGSMKGNIFRIAHLGYMSDYDVIIALTSLEKVLRRLGFKVEYGTGARVAMEIFEKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E0HXU2</accession>
    <name>E0HXU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">Theba_1811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731292.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1811"/>
    <dbReference type="EnsemblBacteria" id="AFK07462">
        <property type="protein sequence ID" value="AFK07462"/>
        <property type="gene ID" value="Theba_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1811"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_6_1_0"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="233" mass="26754" checksum="29161DD8424C4AD8" modified="2010-11-02" version="1" precursor="true">MKRIVTIMFLLVLIGVFTMASTEIPVVDANLPENLETATFGLGCFWGSEAIFGGISGVYRTSVGYAGGTKVNPSYYSLGDHTEVVQIQFDSSVISYEELLELFWLSHNPYVNYKIQYMSLILYHNEQQKETAEMFIDSKENEAGRKAATEVSRMTEFYRAEDYHLKFYLQRDKEILNDLLRYYEDIFALNDSTVAARLNSLLAGKGDPDLMKNEYEDYGLQNRALEKVRKMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H5</accession>
    <name>I2F1H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729958.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0023"/>
    <dbReference type="EnsemblBacteria" id="AFK05778">
        <property type="protein sequence ID" value="AFK05778"/>
        <property type="gene ID" value="Theba_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0023"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_1_0"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="17559" checksum="A2FE0D39D82C19ED" modified="2012-07-11" version="1">MTLYDRIQQDMKEAMKARDSLKTNTLRSVISSVKMYLASSEEARSGELTDEIVIGLVRKEAKKREESIEAYRKAERDDLVQSESEELEILKSYLPEEMSPDEIRAVALKTIEDLKANNPSDLGKVMRELMVRLKGRVDGKLVNKIVRELLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I1</accession>
    <name>I2F1I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase with chaperone activity, ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729962.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0030"/>
    <dbReference type="EnsemblBacteria" id="AFK05784">
        <property type="protein sequence ID" value="AFK05784"/>
        <property type="gene ID" value="Theba_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0030"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="829" mass="93764" checksum="3978D8794E8FB986" modified="2012-07-11" version="1">MYFDKFSEGAAQVFVTAQDEARSLGHPYVGTEHLLLAIIKVENELTTRILRNYSITYERISREVTSMVGTNVHQSVVGAPQMTPRARRVIELANDESKMLGQDKIDVEHIMLGIVREGEGIAAHILKQMGVNLSQLRREIIENITGDWEEGGEQPENVFVQPSSTMGPAIKQLEGFGIDLTAMAKAGKLDPIVGREIERQRLMEVLSRRKKNNPVLIGEPGVGKTAIVEGLAQMIVDEEVPETLKNKVIFALDVASLIAGTKYRGEFEKRLKKLIHVVKTNGNIILFIDEVHTIVGAGSAEGAVDAANILKPALASGEIRCIGSTTPDEYRKYIEKDAALERRFQKIYVTEPTPEESVEILKGIRHKYELHHKVHYTEKGLEAAVTLSHRYVSDRFLPDKAIDIIDEAGSRARLKKLTIPDELKKMQGDIESLKIKRETAAADQEYEKAAQLKEKERLIQQKYRDGYNDWRNRVDSEIVTLDDDEVAEIVSNWTGIPLRKLEETDSEKLLTLENALHERIVSQDEAISAVAKSIRRARSGLKDPRRPIGTFLFLGPTGVGKTELAKALAEYLFGDDKALVRFDMSEYMERFSVSRLIGAPPGYVGYDEGGTLTERIRKRPFSVILFDEIEKAHPDIFNILLQIMDDGRLTDSQGRQVDFRNTIVIMTSNLGGEFINKTKSSIGFVESSHEEKEYEAMKTSVLEEVKRTFRPEFLNRLDEVVVFHQLTKDQIKTIIDILMNDMRKRLNEKHLKLILSEAAQEFLVEEGFNPVYGARPLKRAIQKYVEDPLSEELLRGRFQDGDLITAEVDNRVLIFKKKKDEKTEVKAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P6</accession>
    <name>I2F1P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein involved in an early stage of isoprenoid biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490179.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0100"/>
    <dbReference type="EnsemblBacteria" id="AFK05849">
        <property type="protein sequence ID" value="AFK05849"/>
        <property type="gene ID" value="Theba_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0100"/>
    <dbReference type="eggNOG" id="COG3155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072952_1_0_0"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026041">
        <property type="entry name" value="ElbB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF12">
        <property type="entry name" value="PTHR10224:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="223" mass="24312" checksum="196E90D151258339" modified="2012-07-11" version="1">MKCGVVLTGCGSEDGTAVDEAIMTFLALDKAGVEVVSLALDKDQYEVINHQTGKPAELEQKRNQLVESARLLSGPVNNIDTFNWEDLDLLVIPGGKGVLKSLSTFEDEEDHYRVNKSLERLIVNCFFGKKPLGAIGEGVLILARALENVASNLTVTASGNPEDRMTVVEKLAIDHVPCEVGEMCVDKTNKVVTAPLLVRENGLMEKNESIETFVKRLFDLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q5</accession>
    <name>I2F1Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0109"/>
    <dbReference type="EnsemblBacteria" id="AFK05858">
        <property type="protein sequence ID" value="AFK05858"/>
        <property type="gene ID" value="Theba_0109"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0109"/>
    <dbReference type="HOGENOM" id="CLU_2974220_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="58" mass="6520" checksum="B598F6E9EA81460B" modified="2012-07-11" version="1">MTAFDVSSLQHFQLATALHERLRMVFHSDQPSAFLSKCPAALKTKILNQVQNDGLLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S1</accession>
    <name>I2F1S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0127"/>
    <dbReference type="EnsemblBacteria" id="AFK05874">
        <property type="protein sequence ID" value="AFK05874"/>
        <property type="gene ID" value="Theba_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0127"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="234" mass="26565" checksum="73F96771FB2E4599" modified="2012-07-11" version="1">MNKYEVTFDEFDAFCEATGINKPDDRGWGRGKRPVINVSWNDSTAYCNWLSEMENLPKAYDENGSFLDKDGIITSDPSRVVGYRLPTEAEWEYAARGGKLSKGFRYSGSNSADEVAWYLYNSEDELLEGPLSGEDGLKAITENNSRSHEVGTKAPNELGLYDMSGNVWEFCSDWYEAYSSSEQTNPYNDSGSFMVFRGGSWFDIENAVRVAIRSGNSRTFRYYYLGFRVCRTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T7</accession>
    <name>I2F1T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730055.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0148"/>
    <dbReference type="EnsemblBacteria" id="AFK05890">
        <property type="protein sequence ID" value="AFK05890"/>
        <property type="gene ID" value="Theba_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0148"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_1_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="46032" checksum="F8849F25369F4B31" modified="2012-07-11" version="1" precursor="true">MRKSTLLVFMMLVVLAFTGVSQVINIWIGGQVAELDETWEMIVGKFEEETGLKVEVQLFGFDIYYDKLLTALQAGQGPDLAFADLGGWVPTFAEKGWLEPMGALLDSWDGTEQIWPNLWPTVLHNGERYGLPWYTDCRLLLYNQTMFDQAGLDRNDPPATWEELVYQAMKLTDASKRVFGYGVSGTKTEHTTLAYIIFLYGAGGQLLTDDYSAAAFNTPEGLRALKFYTDLALTYAVSPNAVTYNEDDYRNMMAQNRVAMAVGGPWSFPLIETANPDIVGNYSVSLHPYGATPASVLGGWALVIPSASKNKDNAWELAKYLTSYETWMTWIEAKGGPMPSRQDVCFDSPVLQDPKWKVIFETFPHAVSRPPIPEYPQVSEQIQIMIQDVLLGKVTPEEAIKTAEANVNAILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U1</accession>
    <name>I2F1U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-1-phosphate kinase/fructose-6-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730059.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0152"/>
    <dbReference type="EnsemblBacteria" id="AFK05894">
        <property type="protein sequence ID" value="AFK05894"/>
        <property type="gene ID" value="Theba_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0152"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_0_2_0"/>
    <dbReference type="OrthoDB" id="1323781at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="318" mass="35273" checksum="D90AABCDE35986DC" modified="2012-07-11" version="1">MKEDNNIDTCILNLNPCYDHWVILKNPTKIPNVVRGDKVVTLVDGKGLNIARVLSKVLGHSEYFCINILGGQVGTIIEKECDRLGIVTENFWIEDSNRINTALVYEYENKMLMINEPGPLMKPGEIESFMEFFKGHVRPGMNLVISGSAPRGFENGSLLQLVRIAREAGCSLKVDIAGSWLSKIVTVSPELLKINADELKVAFGINKDDFKSMDDFRREYSIRDLIITNGKMGSVWLSESEKLHARSMKVFSDFSVGSGDSFFAGLIYGQEAKMSKREALKIATACGAANTMHYGAAIFEYSDVEKVIGDVVVTEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F204</accession>
    <name>I2F204_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flg_new_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730119.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0223"/>
    <dbReference type="EnsemblBacteria" id="AFK05957">
        <property type="protein sequence ID" value="AFK05957"/>
        <property type="gene ID" value="Theba_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0223"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155349_0_0_0"/>
    <dbReference type="OrthoDB" id="558757at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="240" mass="25872" checksum="B6EE96F5491E7E4B" modified="2012-07-11" version="1" precursor="true">MKRVIKICLISVFIISIISLTGCIKPTFQVVVQITPAGGGNVTGGGSYKKGEMVTLNAINSEGYRFLHWKSDGAFLTDQNPYSFRIAGNVSLEAVFVADAGEISIADAYFVVDEESHVKINGVGLGAVNLIEVVIEYDPNVLSWEGSSCRIAGWITIEKNPSPGIAHIAISGASTEINEEKELIRVYLLPKKAGISDVKFTTYESEGGVFFETNYITAGGLKKTYPELGLKKGVITVNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F290</accession>
    <name>I2F290_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system FeS assembly protein, NifU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730186.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0313"/>
    <dbReference type="EnsemblBacteria" id="AFK06043">
        <property type="protein sequence ID" value="AFK06043"/>
        <property type="gene ID" value="Theba_0313"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0313"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_0"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="16028" checksum="CBDA01852700B932" modified="2012-07-11" version="1">MNFEQLYSDFIMYHFKNNSHRGRIEDCTYTVEGSNTSCGDSITLYLIIGRGVVDTIGFEGEGCAISQASAAVMTEILEGKSLDEAAATIVNFEKMIRGEDYDGSKIGDAAFFEGLKEHPMRAKCVILPWKTAAKVLVSKQQKKTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A9</accession>
    <name>I2F2A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type transport system involved in Fe-S cluster assembly, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730203.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0333"/>
    <dbReference type="EnsemblBacteria" id="AFK06062">
        <property type="protein sequence ID" value="AFK06062"/>
        <property type="gene ID" value="Theba_0333"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0333"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894122_0_0_0"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="318" mass="35476" checksum="D0E140EA3380DD5B" modified="2012-07-11" version="1">MINSNFEREFTAIAKEYERAGGNVSDFLRKDIVSIIVSGNKVIGRNTVDGVHVRAKELTNGVEIWLEIDGGTVIENPIHLCTGYLKPEGTQEVLIHNRLGDHTKAKFISHCVFPSGVNFTHSMIADTDVGNYSEMLYEDTHMHSKDGGVTVKATYNTVVREGGRFQNLFYLTKTRVGKLFVKMNVDLEKDASAHIESKVYERDDDYLEIDEQLYLNGEGSSGIAKTTVFATDRSRAKIINKAYGNAAYSKGHIECNEIIKGDSVEVGTVPELYVRNEKAELTHEASIGRVNVKQMETLMSKGLTEEEATDMIVRGMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C1</accession>
    <name>I2F2C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">Theba_0345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491920.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0345"/>
    <dbReference type="EnsemblBacteria" id="AFK06074">
        <property type="protein sequence ID" value="AFK06074"/>
        <property type="gene ID" value="Theba_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0345"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_2_2_0"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="19699" checksum="3943F546A3A16A74" modified="2012-07-11" version="1">MIVVEILPKGEGLFCPLFFIMVVLFVEDLKKELFELANEVASNLGYSIYDLGLGRRGKKRLVKITIDKLDGYVSISDCESFSADFGRALDSADLVPFSYDLVVESPGLERALRDLKDYVRFTGEKAKVILKEPIEGVSVLIGKIISCENDVVTVESSENGKEIAFHFSNVKRANLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L9</accession>
    <name>I2F2L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730287.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0445"/>
    <dbReference type="EnsemblBacteria" id="AFK06172">
        <property type="protein sequence ID" value="AFK06172"/>
        <property type="gene ID" value="Theba_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0445"/>
    <dbReference type="eggNOG" id="COG1311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703425_0_0_0"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="50245" checksum="3A550CEC6A7238E0" modified="2012-07-11" version="1">MKKLYLSDLHIGDGTLKDDFKFDSDLVELILSSKEKAFREIIIVGDGLELLTSEFVKKRGLLPFDQLIDQLDVSLIDVIENRHREVFRAFREFTKSGRLIYVVGNHDSFLLFNEGLRKRLTEFLGDSESVQIQPYYLDREFKTLALHGNQYDIVNRFFKDRRSGELMQPFGDYMARFMMKNFDKCLLRKELPEQAVRDYQNIHPTLDVFQWFDFIRRVYDVDSDLQDEWARQFLLMLKSDAAQRWIDASWPMLKVIEGLFINKHGGMKLGSLMVRMVMAFRKLKKTDNLYKQGRRLLGAEGKKGFRKAMNNEFFLMYGDKAPAIVPGELKGVIMGHNHRHVLRMISSNGEEKFYANTGTWKPVVEMIDDDPRNGFARRVELGYITIEIVSNEFLVESKHIKKLSGLRFSEDTLDKKTEWNSVREIGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q4</accession>
    <name>I2F2Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730319.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0481"/>
    <dbReference type="EnsemblBacteria" id="AFK06207">
        <property type="protein sequence ID" value="AFK06207"/>
        <property type="gene ID" value="Theba_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0481"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122749_1_0_0"/>
    <dbReference type="OrthoDB" id="1613263at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="16784" checksum="3ED35F15AA5D6790" modified="2012-07-11" version="1">MITVGDMLDIALRIESVGYSYYQKLSEKTSGEVKSLFVKLATQEREHAAVFRKMLKDADNSLIAKDWEDNVGYLKSYAEISIFPRTESIDVPDNINKAISSAVEVEKDSIIFYSDLSSFIPDCKELKDIIEEERRHLHDLVKLYGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R1</accession>
    <name>I2F2R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492107.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0488"/>
    <dbReference type="EnsemblBacteria" id="AFK06214">
        <property type="protein sequence ID" value="AFK06214"/>
        <property type="gene ID" value="Theba_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0488"/>
    <dbReference type="eggNOG" id="ENOG5030SR3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107131_1_0_0"/>
    <dbReference type="OrthoDB" id="1710953at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046272">
        <property type="entry name" value="DUF6305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19823">
        <property type="entry name" value="DUF6305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6305" evidence="1">
        <location>
            <begin position="33"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="200" mass="21975" checksum="E7E8CCE6302F3171" modified="2012-07-11" version="1" precursor="true">MRKVLIVVLLSMVLFTTGLFAVVSGDPVVEGQLPFLLTNAGQGPGGKMARLLIWQSGAIEDTDFDYNAEPLKENPNDLTAREYKMLFVIIGSSAKGLGASGITIDEEIVRLNKMIEEAKRLNMFIIAAHIEGKARRGNPGSADERSIDAIAPYADYLIVMKEGNLDGKFTRIAEEKDIPLTLIDNTIDFMQVIKLMFPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R2</accession>
    <name>I2F2R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRAP-type C4-dicarboxylate transport system, large permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492109.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0489"/>
    <dbReference type="EnsemblBacteria" id="AFK06215">
        <property type="protein sequence ID" value="AFK06215"/>
        <property type="gene ID" value="Theba_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0489"/>
    <dbReference type="eggNOG" id="COG4666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645132_0_0_0"/>
    <dbReference type="OrthoDB" id="901005at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="433" mass="47282" checksum="FF1FDAE9AD62A353" modified="2012-07-11" version="1" precursor="true">MYLQTTIIAIIMVATFALASWKLKSPEISMVITAIVGALVGGFGFPSRLLVEGMFTYFDVGMIFLTASIFINIYSETGAMNALVRWIVKQFYDRKWLMLVLLGILMIIPGALTGAGSVSIFVVGGLVASVMSYMGFSKRRVAAFIYLFAMLAAVSPPINLWAMLMAAQANMPYVGFNVVLLVPIVIIALFTIVYTGTSKTPERKSKEHILSELPLPPEGMNWFKIITPFAVLLVLILLSKFAAFSIPVLGLPLTFVICAFASAMMDRKRWDVRKWFDVMVKTMDQVFPLLATVISVGALVNIMTATGVRGLLAITFITLPMVFIYITALLFAPFAQGALSYGSAIILGTPIIFLFNSVGLNVTVTAAALSLLFPLGDCLPPSRIVGRLTVETVGYEGSYMSFLKAIAIPWLFMGAIGLLMLIFPNQLDFLVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R9</accession>
    <name>I2F2R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730329.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0496"/>
    <dbReference type="EnsemblBacteria" id="AFK06222">
        <property type="protein sequence ID" value="AFK06222"/>
        <property type="gene ID" value="Theba_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0496"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694092_0_0_0"/>
    <dbReference type="OrthoDB" id="453710at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021228">
        <property type="entry name" value="BrxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10923">
        <property type="entry name" value="DUF2791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="397" mass="45489" checksum="76E0DD423A8FBC87" modified="2012-07-11" version="1">MDYHPMFEAIRAGTAVPVDFVTEILTGREKYVQEIENDINYILTGRSKVRVFLGEYGLGKTTLARYAEYVSREKGMMISCLSEKDYDTLHKQDEFFRSIMKNMTMVGINGNPLKIFLRAWAEKTLGELEELRIPSDDVNSVREYLSTRDNYDPDGMFSHFCAAYVASAGQGAPGEEFYAYLVGDSVDKRTMKKHGIYHFLQDDGWNFLKSFTSLMDTLQVPGLVIIMDELESTMNRRRDVRDRTFNQLREIIDKMSAGFLQKTYFLWLGTDVWFENKHRGIASYHALYDRMKNISGDNSGKTIILNLEPLGKEDLRQLIRRLKTLYASCYSYTADSSFEETTLQSLVKQYTGIDGKLRPSVREVAKLTVEFLDSLRQGKGQEGNGDADSVKAADQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X2</accession>
    <name>I2F2X2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Theba_0552</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730372.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0552"/>
    <dbReference type="EnsemblBacteria" id="AFK06275">
        <property type="protein sequence ID" value="AFK06275"/>
        <property type="gene ID" value="Theba_0552"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0552"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_0"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="4"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK06275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="43599" checksum="19B832C0676F6674" modified="2012-07-11" version="1">MKRVVVTGMGVISSIGTNLTEFWESLKSGTSGIDWISTFDVSEYGAKVAGQVKNFDPTKYMDRKDAKRNARFVQMAIASASEAYDDSGLGNSRINSERAGVIYGVGLGGMDVIEDQHSVLMNKGPSRISPFLIPMTIANMAPGLLAIRFNFRGTNFTLSTACASATNAIGEATRLIRAGILDIAMTGGSEATVTPLALAGFSNMNALSRGTPKTASRPFDRDRDGFVMAEGSATLIIEEYEHAMKRGAMIYGEVVGYGSTDDAFHITSPEESGDGAYRAMKMALEEAGVDPSEVDYINAHGTSTPLNDLMETRAIKRLFGNRQDLNISSTKSMAGHALGAAGAIEAVATLLSMKNSFIPPTINYSSPDPECDLNYTPNFGVEKELHFVQKNSFGFGGHNASLLFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X7</accession>
    <name>I2F2X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic serine protease, Do/DeqQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730377.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0557"/>
    <dbReference type="MEROPS" id="S01.491"/>
    <dbReference type="EnsemblBacteria" id="AFK06280">
        <property type="protein sequence ID" value="AFK06280"/>
        <property type="gene ID" value="Theba_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0557"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_0"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="259"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="466" mass="49550" checksum="87F214160D9431EB" modified="2012-07-11" version="1" precursor="true">MRKVLAVLVVVILSVASLALVNEGYESPITNVVQAAGPAVVKVDVEATRKYSIPDPYGFEDFFRRFFGEIPGQKVTGVGSGFIFNKDGYIFTNEHVVSGAEKITVSLLDGNTYPAKYIGGDEELDIAVIKIDPDGVDLPTVELGDSDALRIGEWAIAIGNPLGLKHTVTLGVISAVGRQLPKPDGNGVYSNLIQTDAAINPGNSGGPLLNIHGQVVGINTAIIAPEVGTTLGFAIPINVALRFVDSIIETGSVQRAYLGVYMDTVTEEVSRSLGLKVDSGALITDVVPGSAAEKAGIRPQDVIIGFESLEITNSAELRAAVLNYPAGSEVKITIDRFGDRIVLTAVLGSLAQESASSATEDIGARQAFVSSLGISVSDITPGDRERLGISQEFRGVIVRDVDPEGVVYRLGIGPDDIITRLSINGNQESIESVSDFEKYTENIKKGDYVAFFVYRNGVRFVASFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y7</accession>
    <name>I2F2Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">Theba_0571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730385.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0571"/>
    <dbReference type="EnsemblBacteria" id="AFK06290">
        <property type="protein sequence ID" value="AFK06290"/>
        <property type="gene ID" value="Theba_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0571"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_0"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="14"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="381" mass="42617" checksum="9EC7D145A5FE5A1A" modified="2012-07-11" version="1">MVELKLKAKSTESKARTGVIVTPHGEFETPVFMPVGTNGTVKGLWQDQLEELDARIILGNAFHLFLRPGLNVLRNFGGLHKFMSWKHSILTDSGGFQVFSLKEKKITDDGVKFRSPLDGRALFFTPELSSEIQEAIGSDIAMAFDECVEPSANKDYVRQSVKRTTVWAERFLLSHKGQSMQSLFGIVQGGFFGDLREESAARITSLDFEGFALGGLSVGEDFQTTERILSGSVNLLPEERPRYLMGIGSPELIMAAVENGIDMFDCVLPTRLGRHGAALTSNGRINLKSSTNKEDKRPVDPDCSCKVCSTYSRAYIHHLFIRDEILGKILLSYHNISFLMQFVKRIRQAILDDRLAEFKEHCIETGLIQTENLKTSEERMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z3</accession>
    <name>I2F2Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492210.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0577"/>
    <dbReference type="EnsemblBacteria" id="AFK06296">
        <property type="protein sequence ID" value="AFK06296"/>
        <property type="gene ID" value="Theba_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0577"/>
    <dbReference type="eggNOG" id="COG4769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108933_0_0_0"/>
    <dbReference type="OrthoDB" id="2030916at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014535">
        <property type="entry name" value="Hpre_diP_synt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027391">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="17904" checksum="1DF1255F87D6A25F" modified="2012-07-11" version="1" precursor="true">MEAKRVTTLSMLMAIGSVLYLLESLIPFPLPIPGGRWGFSNLVLIIALAGLPFGDILTLSIGKSIIGSLLAGRLATPGFLMGVAGAVSSAATMWLMNKTGKFGLFGISVAGAAISNFSQLMVASSLIIKNIEIIFLYPYMLVLGSISASINAYVAFEVIRRMGDSLWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z5</accession>
    <name>I2F2Z5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492213.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0579"/>
    <dbReference type="EnsemblBacteria" id="AFK06298">
        <property type="protein sequence ID" value="AFK06298"/>
        <property type="gene ID" value="Theba_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0579"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_1_2_0"/>
    <dbReference type="OrthoDB" id="2021063at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="346" mass="38310" checksum="DBE7D30E591AFE90" modified="2012-07-11" version="1" precursor="true">MPKRNPNSLLRNRIFLYGLLFVSAIILLTIVFFRQKPLEYYDKTEYHLGTYVTIRVSSSTMSPVTLAEAAMTEIKRIDDKFGSRNNGVIAELNRTGELHDIDKETSFLIRSALEIARNTSGAFDPTLYSLTRLWGFDDASSKKRIPSDKEIEDALGSTGFSRVTYDEELGYVSLVDGAMIDLGGIAKGYAVDMAIAKIKSLDPEATGFIDAGGDIGVIGPKYGNRPWIVGVRNPRGESVQDVLEYIYLYDGAVATSGDYERFFIENNVRYHHIFDPETGFPSRSGVISATVIGKSTMLADAYATAAFVIGMEPGVTFLPRFGALVLLVMEDMSIFRSPGFEVYQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F319</accession>
    <name>I2F319_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730402.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0603"/>
    <dbReference type="EnsemblBacteria" id="AFK06322">
        <property type="protein sequence ID" value="AFK06322"/>
        <property type="gene ID" value="Theba_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0603"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050656_0_1_0"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="35323" checksum="0A588B83E210F19F" modified="2012-07-11" version="1" precursor="true">MAWTGLLVGLAFGIILQRGRVCFNSAFRDVLLFKDNYLWKLGFLAVGLQMITVLFVAQMGWIKIAPPTLNLFGNIVGAYVFGLGMVLAGGCASGVTYRSGEGMTTAMIAAVFYGIGAMAMRGGVFSPIRTWASQFNVSVDANSSVYLDKVGPTLATVLNINPWIPAVILAAVLLWYTLGTKTTERKTKFNWKVAAVSLAILSPIAWITSEAAGRNYGFGITGGWVSIFDSYISNQPLRWDGFEIIGIIIGALIASLLAKEFKLRMPKNPKTYLVVMIGGTMMGAGASLAGGCNIGHFLAGLPTLAISSIIASVFLILGNWTMAYILYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F343</accession>
    <name>I2F343_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_0628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730424.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0628"/>
    <dbReference type="EnsemblBacteria" id="AFK06346">
        <property type="protein sequence ID" value="AFK06346"/>
        <property type="gene ID" value="Theba_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0628"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_9_0_0"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="791" mass="87482" checksum="40BAF0D0817DA311" modified="2012-07-11" version="1">MLQLKEASKIYRTGELEQTALDQVSICFSNDEFVAILGPSGSGKTTLLNLIGGLDRCDMGDLVINGRSTRDFKDWELDAYRNKSIGFIFQSFNLIPHLSLLDNVEIGMTLGGVPSSEKEKRAIELLEKVGLADQAHKRPCQLSNGQMQRVAIARALANDPDIILADEPTGSLDTQTGEETVKLIKEVARGKLIIMVTHNEEIANRYADRIIKLKDGKIVSDSRPSDDDDPQPELIIKKTSMSFPAALRLSATNILTKKWRTALTVLASSIGIVGIFLVLSLSSGFGRQLSEFESQTLSTFPIMVSQTTVDLESQQYHQAESEKRFEEDDSDVLGQFVYPYDPRDEILIHNNDLSDEYLAYVESIDPKLLSGFTYTRHINMNLVAKYGEMAKTVDQTSIKFTAYPEDLDPESPGYLENNFDLVAGSFPKEFTDLVMIVGKGNRISNVILQALGLDHDKERIGFEEIIGLEIKAIYNDDFYLRKGMSFTPKTSLRDLMDLYYGDLGIMLKIVGILRPKAQIEFSVLDEGIAYSDRLAQKFIENAVDSEIVLAQKDLYVNVLSGEQFASDLFNVLSVIPPDITARLVGGVNLPITKRNILQKLGAYKTPVSVVLYPKDFKSKEEVLKYLDSWNEGKAAENRILYIDLASTITGLLAGILNGSTFVLLSFAAISLVVSLIMIGIITFISVTERTKEIGILRALGARKKDISTVFNAENFIIGAFSGALGILFASILIVPLNSIIERLTGLSNVAYINPFYVISLMVASILLTVLGGLIPSRMASRKNPVDALRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F345</accession>
    <name>I2F345_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492279.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0630"/>
    <dbReference type="EnsemblBacteria" id="AFK06348">
        <property type="protein sequence ID" value="AFK06348"/>
        <property type="gene ID" value="Theba_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0630"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097888_0_0_0"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="256" mass="29365" checksum="F0DBA81469856FF1" modified="2012-07-11" version="1">MRESWEYYSEIASRYDYMYEEPYWNLYHRIVERLLEDHVKTIGRTLDIGTGTGRWALYLAEKAHEVVGVDLSQEMLSVASMKAGLADLKIDFVHSNAERLPFEKECFDYVLAMGDLLSYAKNTSEVLAECQRVLKRGGLLLATVDNAWAFLHDFLSRGEYSMAKRLVEKDKIPIGDSSVSSIVFATKPFFPEEIGHLLNMNGFDLIDISSVVAFYPYDEQALAAKIDSAVDWELKYCRNRETLARSEHLFLCGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A9</accession>
    <name>I2F3A9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ORF">Theba_0695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492362.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0695"/>
    <dbReference type="EnsemblBacteria" id="AFK06412">
        <property type="protein sequence ID" value="AFK06412"/>
        <property type="gene ID" value="Theba_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0695"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_2_1_0"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="62" mass="6982" checksum="C740BA92B3927397" modified="2012-07-11" version="1">MAKSLRIRLIKSPIGYNRRQLKTVKALGLGKLDSEIVQPDSPQIRGMVNSIRHLLAVEELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B5</accession>
    <name>I2F3B5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">Theba_0701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730478.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0701"/>
    <dbReference type="EnsemblBacteria" id="AFK06418">
        <property type="protein sequence ID" value="AFK06418"/>
        <property type="gene ID" value="Theba_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0701"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_0"/>
    <dbReference type="OrthoDB" id="2066169at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="38" mass="4557" checksum="65FC565808489F98" modified="2012-07-11" version="1">MKVRASVKKRCEHCKVIRRNGRIRVICEKNPKHNQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C0</accession>
    <name>I2F3C0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">Theba_0706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730481.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0706"/>
    <dbReference type="EnsemblBacteria" id="AFK06423">
        <property type="protein sequence ID" value="AFK06423"/>
        <property type="gene ID" value="Theba_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0706"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_2_0_0"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="160" mass="18362" checksum="7C61CF2EB8205328" modified="2012-07-11" version="1">MRHRVSGSKLNMPHSQRVALMRNLARELFEHGTIVTTVTRAKELRPFVESIITKAKKASLLSVEISSKGPDSTETQALKSRNLALHREINRNFNDRKLVKKICDEVAVKYHERNGGYTRIVKLGMRRGDASEMAVLQLIDNEEKQEKKPEKKAEKKQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C8</accession>
    <name>I2F3C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730489.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0714"/>
    <dbReference type="EnsemblBacteria" id="AFK06431">
        <property type="protein sequence ID" value="AFK06431"/>
        <property type="gene ID" value="Theba_0714"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0714"/>
    <dbReference type="eggNOG" id="ENOG502ZF98">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1978896_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="126" mass="13808" checksum="99AD74FAF0A8231F" modified="2012-07-11" version="1" precursor="true">MSFTELLCCLVVVSLCISGVVLVSSDIIASLKIVLSKTALDSFIESQRLEAVVRSRPVDVFYDFRSRRVSSTTGMVFEDCLWENPENFRIRFNGDGSIAILSGSTTLNFADGSVLTIQPVTGKVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G5</accession>
    <name>I2F3G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730522.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0753"/>
    <dbReference type="EnsemblBacteria" id="AFK06468">
        <property type="protein sequence ID" value="AFK06468"/>
        <property type="gene ID" value="Theba_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0753"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="34957" checksum="FD97C4CC51250593" modified="2012-07-11" version="1" precursor="true">MKKFVPYIFIAPAGLIIAFFMLYPLFYSFAISLFEWDLSPNMTFVGLRNYSEILSSSEFWDSMLYTAYYILGVLPFSLLIGFLIATLLNDSTMKGIGFFRMIYFLPVVTSPIAAGMGFSFLFSTELGYVNHIIASFGGEYVNWLTNPEGIFQILLNWTGITLPKVLQGPSVSLFVIILMGIWQNIGYAMVVYLAGLQNIPTTYYEAASLSGASKFQMLRKITVPLLSPTTFFLLIMFSISSFQVFGPIMVMTPDGGPLNTTSVVVFRLYREAFSYYRFGYAAAMAFVLFLFVISLTALQVRTIERTVHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K4</accession>
    <name>I2F3K4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="9" type="ORF">Theba_0793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0793"/>
    <dbReference type="EnsemblBacteria" id="AFK06507">
        <property type="protein sequence ID" value="AFK06507"/>
        <property type="gene ID" value="Theba_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0793"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="403" mass="44488" checksum="053DD0A8ECBF8C97" modified="2012-07-11" version="1">MPFERHCSFCGRSAAQVKKLISGTEGYICNECVDLFHDIIQQDQKAKKEPGKKLPTPADIKKELDKYVIGQENAKKTISVSVYNHYKRVFNDVDDVEIEKSNIMLVGPTGSGKTLIARVLARILDVPFAIADATPLTEAGYVGEDVENIVLRLLQSANYDVEKAQLGIIYIDEIDKIARKSPNPSITRDVSGEGVQQALLKIVEGTTANVPPQGGRKHPYQEFIKVDTSNILFIVGGAFDGLDSVIKQRVLDSSMGFGAKVKGKNQLRLGEVLQQVVPDDLIQYGLIPEFVGRFPVLAALNDLDVEDLKRIMSEPRNAILKQYQRLLGLDGVELEFSDDAMTAIAERAMKRGTGARALKSVIEQVMLDIMFDIPTMNNVEKVVINEDVISKNSSPEIISRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M7</accession>
    <name>I2F3M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730577.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0816"/>
    <dbReference type="EnsemblBacteria" id="AFK06530">
        <property type="protein sequence ID" value="AFK06530"/>
        <property type="gene ID" value="Theba_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0816"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_0"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="281" mass="31283" checksum="800AADF0CA735786" modified="2012-07-11" version="1">MTFENGRVLDLSEPRIMGILNITPDSFFPGSRFLDIPVALDKALEMLENGAAIIDIGGESSRPGAEKVESKEEIARVLPLIKQLRSKRPDAVISVDTYNSETASAALSEGADMINDITGLRSMKMIEAVSENHAAVVIMHMRGDPSTMSRMTDYRDVVGEVSSWLFERARRAIDFGVDPDRIILDPGIGFAKSAEQSIEILKNIEKFKKMGFPVLVGHSRKSFISKITGTPVEERLEETISISTYLYRKKVNIIRVHDVQEHGRIFGILKTLNPSGEYWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q9</accession>
    <name>I2F3Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0849"/>
    <dbReference type="EnsemblBacteria" id="AFK06562">
        <property type="protein sequence ID" value="AFK06562"/>
        <property type="gene ID" value="Theba_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0849"/>
    <dbReference type="HOGENOM" id="CLU_3329962_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="38" mass="4822" checksum="6F72A4A821EE83E5" modified="2012-07-11" version="1">MKEVRKMRGRERKVHYREREIYSNIVEDSIRSRVMNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R7</accession>
    <name>I2F3R7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">truB</name>
        <name evidence="9" type="ORF">Theba_0860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730609.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0860"/>
    <dbReference type="EnsemblBacteria" id="AFK06570">
        <property type="protein sequence ID" value="AFK06570"/>
        <property type="gene ID" value="Theba_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0860"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_2_0"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="7">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="6">
        <location>
            <begin position="234"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="306" mass="33710" checksum="F4F8ED266DA1E097" modified="2012-07-11" version="1">MSDGIILVDKPVGITSHDLVNLLRRRLGTKKIGHAGTLDPFASGLVISGVNKGTRILEYFLEMDKTYRTELVLGRITDTFDITGRTVEERKVPGFCFNEVFNALKSFEGEYLQVPPAYSAKKYNGERLYKLAREGKIINLPPKPVKIYSIDDIGISYEKVTFTAKVSKGTYIRSLVMDIGYKLGCGATVTELRRISQGNFSVDSAHQIDDVSDFSIISLEDSIDFLPGLLLNDSESSNVLLGKQIYASGVAGVMGKFAKNDLIRIIGSDERLLAVARSERTSSFIKTLLAKNSLERVAKLEKVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T0</accession>
    <name>I2F3T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730621.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0873"/>
    <dbReference type="EnsemblBacteria" id="AFK06583">
        <property type="protein sequence ID" value="AFK06583"/>
        <property type="gene ID" value="Theba_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0873"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="503" mass="57993" checksum="F5E7E712ECD1178D" modified="2012-07-11" version="1">MFRIDFQLDKDSTVPLYLQLIERLRKKILSGEYPDGSKLPSVREIEQLLGVSKNVVLKAMNELYVDDLVYREVGSGTYIRAKKEKGADTGPIDWCKHLDTWYRHTHQFKKRSPTSEIATLGLLVIFHNESPDDELIPHQLLKALTQRAMKSDIFMETVNYVEHPKGLRDLRKAICMRLGCNGESLKPENVIVSGRNVESEHLIFKAFTRQGEAVVIENPTNMNVLGILKTLHLKVIPVRRSIEGIDLNQLEDVLRKNSVKLIYLQSTAGEPMGTTMPDRKKQELVRLAASYRVPIVDDLTGGSEFQYTGKTPFPMRHFEEDNVVFEIHDIVKTFGAGVTTGWIVGPDKALDILWSSMRVMERDVAGLLQLVTNEILNSEFYDHHLSFVHEKLTKRRELLIHACNRYLPSYAKANICDSGTSWWVELPKGFDVRDIRRNLNRKNIEIAPGNWFFNDEKGYNFFRLGLYVKEEYIEPALIEIGKTVERYRKHEFGSVTKFEYTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U5</accession>
    <name>I2F3U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">Theba_0888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730636.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0888"/>
    <dbReference type="EnsemblBacteria" id="AFK06598">
        <property type="protein sequence ID" value="AFK06598"/>
        <property type="gene ID" value="Theba_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0888"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_0"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="21039" checksum="46AACF8393E6D963" modified="2012-07-11" version="1">MIEVGKIRKGMPLIIEEEIYIVTEANKHSMGRGDGIIRTRMKNLKTGLVRQFTFQASEKVEEAALSFRHVQYLYSEDELFHFMDLETYEQYTIGVDEMGDALDYIKENEEVDLQFHEDRPIGVILPNTVVLKVTDTAPAYKGDTVSGSGKPAVLETGLKVTVPFFVENGERIRVDTRTGEYIERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V5</accession>
    <name>I2F3V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type branched-chain amino acid transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730640.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0898"/>
    <dbReference type="EnsemblBacteria" id="AFK06608">
        <property type="protein sequence ID" value="AFK06608"/>
        <property type="gene ID" value="Theba_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0898"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="38127" checksum="ED1B1F151E080F67" modified="2012-07-11" version="1" precursor="true">MDRKLKLVITIIELLVFILLLWLAENYIDAFIKRILNVAAIYVILGVSLNLINGFTGQFSLGHAGFMALGAYASALLYMSPSLKAMNFFIQPIIWPLSEIEIPFFFALLIGGTVAAIAGFAVGAPCLRVGGDYLAIVTYGFAEIIRVILNNLQSITNGPLGLKGLPTYTNLYWSWGWALFTVFFIKKLVDSSYGRALKSIREDEVAAEAMGVNLFKHKTLAFVIGAFFAGIGGGLLGSLLMTIDPNSFNIALTFQIVMIVLLGGLGSITGSVVMGISVAFLMELLRFVESPMTIFGFTIPGIPGMRMLIFALILVITVIFFRRGLFGHKEFSWTWIFRSKGRNANESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y7</accession>
    <name>I2F3Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MobA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730662.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0934"/>
    <dbReference type="EnsemblBacteria" id="AFK06640">
        <property type="protein sequence ID" value="AFK06640"/>
        <property type="gene ID" value="Theba_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0934"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_1_1_0"/>
    <dbReference type="OrthoDB" id="1904831at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="190" mass="21299" checksum="A664FF7361C8DDD1" modified="2012-07-11" version="1">MESNSVSLILLAAGESSRFGDEKLCSNFRGKPLLQWSLDNLKNVGVLNKFLIIKPGFELNRFDTGSFKILINDDYRKGISTSIVRGLCECAEERTGIVLMLADMPLVSGEDVEFLLESLLPEDEMVSFVYDGRKGFPTFIAKKLFPELLKITGDRGAFQLVKNGQAKIREIEGSERNVFDIDSPEDRLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F441</accession>
    <name>I2F441_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein, putative virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730709.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0988"/>
    <dbReference type="EnsemblBacteria" id="AFK06694">
        <property type="protein sequence ID" value="AFK06694"/>
        <property type="gene ID" value="Theba_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0988"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_4_1_0"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="498" mass="54619" checksum="54F204FBD0E55D1A" modified="2012-07-11" version="1" precursor="true">MKRLPRSTSVAAGTIAILTFSIISKGMGFFREMLVAGLFGTSANLDAVFVAMTPATTLSGIIAGALAAIFVPVYHSIRNEDTERSKRYAGAVLISGSLVFLSMGIVFLLIPDLVIRLFAPGFSSEIVAYASRKLRYLSIYPLIGGLESILGAVLKSNRRFVQYGMSQLFFNVIAIPVILLTSPFLSEASYILAWMLGNAITVLLYLIQSRDLFTLRVGKGTSIVETLYLSLPLIFSGSLGVINNMVDKAFVSLLPPGRVASLQYAHTLLGLITFTISAFQMTAYTELSELIVSGDRERVEERLRKTVTTSLNISLPLAAWIIMMAEPLVRVIYQRGEFDAGSTNLVSMALIGYGALIVLSPIAHTCSSYFTARKKLKSITLVAVFSIFLNALFDWLMLEPFGHAGIAASTSLVVLNATLIYVLLIAREGLRFMPLKRIMRLLGSSVAMYLIVLLLRNNVSTWIWLLVGNGLFLCLFLVSAKSEMKAMMSRISFLFKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F459</accession>
    <name>I2F459_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K+ transport system, NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730723.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1007"/>
    <dbReference type="EnsemblBacteria" id="AFK06712">
        <property type="protein sequence ID" value="AFK06712"/>
        <property type="gene ID" value="Theba_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1007"/>
    <dbReference type="eggNOG" id="COG0490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050982_0_0_0"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="113"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="40346" checksum="6A8768BC3075F3F4" modified="2012-07-11" version="1" precursor="true">MTNETGGAKQIVVSLILLAAVFLVGIIGYSIIEGYSPIDSIFMIMITISTVGYGTITELSQAGKIFTSIVILASITIVVYAVSNITAFLVEGRVNKMIRRRRILKTIEKLENHFIVIGGGDLGSTIAHEMSKRNNDVVIVEKSEERLKDLTSREGGKLIYVSGDATEEETLKSAGVEKAQGLMSWLPDDVDNIFVVLTARGMNKSMKIISKVAHRENINKLNYAGADKVIPIQEIGAHRMVTMMLNPTVIGFLDTISQSGSLQLRFEEVKVPGNFRPEGMTLEALKIPQRIGLIVIATVCDGVNKFNPSASTIVKPGDSLMVLGEHEQVEKLQSLLGGNLNVEPQENNSFIPLILEGNYLSTPVAGEFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F463</accession>
    <name>I2F463_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730727.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1011"/>
    <dbReference type="EnsemblBacteria" id="AFK06716">
        <property type="protein sequence ID" value="AFK06716"/>
        <property type="gene ID" value="Theba_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1011"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_5_2_0"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="372" mass="41281" checksum="F7151CBD9633FF22" modified="2012-07-11" version="1" precursor="true">MHSKVIIVGAGPAGLAASRIFARDGIDFLLLDSKSFPREKGCGGGLTPRSLKRVHEIFPEVDIEGFDCHELSINRLIDGQMKHLTTLMSKKTIFKTVDRKEFDNALLKSIVERGGRFLSSRVREIVKEEQGFVVKTDERELTSDYVIVSAGVFGAKLLGHEPPSFGVAYYGYSSPTGSASVTFIPNGYLWSFPGESFDSVGGGIYPDSEKTPSYEEMSTLIKRSFGEEIDLRGTPIPTFNTDVVLSLNNLYTNLLVAGDSAGLVDNWTGAGIDFALDSGRQAALSIIEDGYKGKTVNERYLERLFPAARHLQIADAFRKRFNRNFEEHLDLLKGRMTGKLLSNYLGYYVKGPYRLAFKSLFTRGISSRQLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A8</accession>
    <name>I2F4A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1056"/>
    <dbReference type="EnsemblBacteria" id="AFK06761">
        <property type="protein sequence ID" value="AFK06761"/>
        <property type="gene ID" value="Theba_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1056"/>
    <dbReference type="eggNOG" id="COG5336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137927_4_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10497" checksum="778E67BF8DDECD92" modified="2012-07-11" version="1" precursor="true">MNEKNKINWTALSTLYQFAVIVIANIVVSGGIGYLLYRFLGMGKVWISFFLLFGAFSGIYNGIRYLLKEAERYDRDKDNDDKNSDNTGSPGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D4</accession>
    <name>I2F4D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730785.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1082"/>
    <dbReference type="EnsemblBacteria" id="AFK06787">
        <property type="protein sequence ID" value="AFK06787"/>
        <property type="gene ID" value="Theba_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1082"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_2_0"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="183" mass="20096" checksum="37DE1E9CED703FD2" modified="2012-07-11" version="1">MTELDNIGNKLRSLRQARKISIKKLADTSGVSSSLISQIEHGKVSPSLNTLKKILNAMGETVISLVQQNSSENTMKGLIKREDRMTVTVAPGLYYEVLSAPNKSYSMFISYLSPDAGTEDFFIHEGIESGIMLKGKIELQLGDSTLILEEGDSITHSSTIPHKWRNLGDEVAIGIWVVCPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F3</accession>
    <name>I2F4F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730803.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1101"/>
    <dbReference type="EnsemblBacteria" id="AFK06806">
        <property type="protein sequence ID" value="AFK06806"/>
        <property type="gene ID" value="Theba_1101"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1101"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_0"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="321" mass="35186" checksum="6D292388FAD4786F" modified="2012-07-11" version="1">MRIAIVGATGEVGRMMLKKLEEENIPAEVIDLYASSRSVGKKFTLKDKTLEVVELREDSFDRGYDYVLFSAGASISRHYSPIAAEKGALVIDNSSAFRSDAEVPLVVPEINGFLVKGYKGIIANPNCSTIQMVLSLSGIYRRYGVKTIVVSTYQAVSGAGNKGVAELEKQEAGEIVSTVFIRQIHRNVVPVIGDLLETGFSTEEMKMVNETRKIFGDDSISVWPTTVRVPVAHGHSESIFVETIEPFTLDGLKSVIENSENVVYSEDHLTPLEVAGSDLVYVSRLRTFDSSRFLFWNIADNIRVGAATNAVRIMKAHMGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F6</accession>
    <name>I2F4F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">Theba_1104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730806.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1104"/>
    <dbReference type="EnsemblBacteria" id="AFK06809">
        <property type="protein sequence ID" value="AFK06809"/>
        <property type="gene ID" value="Theba_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1104"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_1_1_0"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="99"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="215" mass="23848" checksum="4FA010901BB990CE" modified="2012-07-11" version="1">MRYGLTGSTGRMGKEIIEVFKGHDLVLEVNDTGIFRHGEPEVIVDFSNREVLKTTIELAVQFGAGVVIGTTALSQSDLTDLRTLSEKVPVVQSYNFSTGINIMKMILREFSSLLKDFEAELIETHHSGKKDAPSGTALMLKDATERDLPIHSLRVGGVPGDHSIVFANEGEVIEITHRAISRKVFAIGALTAARFCLEHEKGFYSFEEVIRWTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M9</accession>
    <name>I2F4M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486506.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1184"/>
    <dbReference type="EnsemblBacteria" id="AFK06882">
        <property type="protein sequence ID" value="AFK06882"/>
        <property type="gene ID" value="Theba_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1184"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110169_0_0_0"/>
    <dbReference type="OrthoDB" id="1291710at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="215" mass="24234" checksum="C0EF81751CA4C93B" modified="2012-07-11" version="1">MDLSEFSFFNPSPNFREMSILKALTESSSVSQERLARIAGIVPSMVNKYIRDFEDSELIQKEGENRRNMKYVLTEAGKFRLQYLTILYLKEAAKLYTESRDIFGEVLDTIKGSDHESFYLYGAGIIGGILADVLRTEGIKIVGFIDDSAAKQNGTFHDLHVFSPEKVDGRDDTAVIVASFRHANHIVKNAKDRGLDNVMVFTISKLGKVELEQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S5</accession>
    <name>I2F4S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486574.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1240"/>
    <dbReference type="EnsemblBacteria" id="AFK06928">
        <property type="protein sequence ID" value="AFK06928"/>
        <property type="gene ID" value="Theba_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1240"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1761696at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="26992" checksum="008189B3489994F4" modified="2012-07-11" version="1">MIETALSLKGFTLLVEGRKMLDGITFDVPKGSIALLQGARGAGKSALLRSFIHLNEELFDRVSYTGSIKLFGEDIDSLERKSVRKRVAYVDTTFLEAMSNFTLIEFFRFLKGKRFEFEDFAESELDLFHELDLLDLLSLKAETSLKTIPLFKRLSLLVFSTLIRHPEIIILDNILDHLDDDACTEVKNVLLDTRNGVTMIISSRFVLRLLDISDLLIVLKNGKISYVGSPEVFVLNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U5</accession>
    <name>I2F4U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730929.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1260"/>
    <dbReference type="EnsemblBacteria" id="AFK06948">
        <property type="protein sequence ID" value="AFK06948"/>
        <property type="gene ID" value="Theba_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1260"/>
    <dbReference type="eggNOG" id="COG5421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031289_3_0_0"/>
    <dbReference type="OrthoDB" id="995276at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="530" mass="62536" checksum="869847862BD51ECF" modified="2012-07-11" version="1">MGIVYQKNKKTGITYVYKNEAYWDKEKQQSRAKRTLIGKLDPSTGEIVPTRSYRKDSISKKPGPVPITKIRRDFYGACYLLDQVGKITEVEADLKACFPDRYRMILSIAYYLILEENNSLSRFSHWQRLHVHPYGEDIPSQRSSELFQSISEEERMMFFKKQGRRRIEKEYWAFDITSISSYSETLRQVKKGRNKEYERLPQINLALLFGEQSGLPFYYRKLPGNITDVKTVKQLMAEFNVMGYKKVSVLLDRGFYSRENINLLFKNHQKFIIGVKLNLNYVKETLEEERDNLQLWSNLQPQFGVYGLCRTTQWEYEQERPNKGDVLSSKRRAYLHLFYNPEKAAKDQAEMNDYLSRLYNDLANNTREEYRMKDYDRFFTVTSTPKRGRKVTPKEEAMREAARNYGYFALLSNEVNDPFEALSLYRSKDIVEKGFGNLKDRLNFRRMQVSSELSLNGKLFVEFVALIYLSYIKKKMQDTGLFDNWTLQGLLDELDTIERFEYPEHGRLIGEVTKKQKDIYAKLGMKSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W0</accession>
    <name>I2F4W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730941.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1275"/>
    <dbReference type="EnsemblBacteria" id="AFK06963">
        <property type="protein sequence ID" value="AFK06963"/>
        <property type="gene ID" value="Theba_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1275"/>
    <dbReference type="eggNOG" id="ENOG5033J37">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1174312_0_0_0"/>
    <dbReference type="OrthoDB" id="1871458at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="236" mass="26823" checksum="8C22B83A6A23FFA6" modified="2012-07-11" version="1" precursor="true">MTGILLLLVGSATRFLLSPLWFFLACTPFYIAFTVLRKRFDYRVLVLAPFVPIVAEIIAIFSGNFRAGFLFGDVICIITVLLGMGDERPKEKMTRELGLSGPINRRRVSSVFYTFGRVAQIEKVNMSQSYSIVHENAFHFTVDVPGTGRVKMTVPLEEIEEVSVHMSMSPGELYLPSLRDMFLPAKKIKMIGKPKIKDYFLLVKTSEDTYSFYEEPSTVLRIQEEIEEAKKKISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F576</accession>
    <name>I2F576_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731024.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1391"/>
    <dbReference type="EnsemblBacteria" id="AFK07079">
        <property type="protein sequence ID" value="AFK07079"/>
        <property type="gene ID" value="Theba_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1391"/>
    <dbReference type="eggNOG" id="ENOG5034CAJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1553457_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="172" mass="19202" checksum="E22EAA3DEA41F08A" modified="2012-07-11" version="1">MITVTFKELSERSGIRYETVRNYVKVLIEEGLIDEVSEEVVEIVKKMPDYTSQGLTVVEAAHRAVSGEQKDSRTSTETLKLKERIACLEEENKLLKAELDKERAPTKQLEEKIQSLEGGQTSSSGIAVYREEAKTAAEALKTAIKSAGSGFVQFLQWLFGAEAEKVEEKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F589</accession>
    <name>I2F589_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731037.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1404"/>
    <dbReference type="EnsemblBacteria" id="AFK07092">
        <property type="protein sequence ID" value="AFK07092"/>
        <property type="gene ID" value="Theba_1404"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1404"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_0"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="268"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="399" mass="42465" checksum="561AF669E9D8264A" modified="2012-07-11" version="1">MKKVFIVGAKRTAIGTFGGTLKDVPAVDLGVTASKAAIEQSKVDPKKIQETIMGCILTANQGMGPGRQVSIGAGVPIESPGYSVNMLCGSGMKSTMIGAQDILTGEAELVLTGGMENMSIAPYMLDKARFGYRMGSGTIVDHMIRDGLTDVFNDYHMGVTAENLAEKYGISRFEQDEFALQSQKRAKEAIATGRFKDEIVPVVIRGRKGDVVFDTDEHPRDTSMEILGKLRPAFKKDGSVTAGNSSGINDGASATVLASEDAVKKYGLKPIAEIVAYAQAGVDPAYMGFGPVPAVEKALKKVSMNIKDMELIELNEAFASQSLSVLKGLMEIYGVSREWLLERTNVNGGAIALGHPIGASGNRIIVTLLYEMEKRNLEFGLASLCIGGGMGTAVVVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D7</accession>
    <name>I2F5D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trk-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731077.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1454"/>
    <dbReference type="EnsemblBacteria" id="AFK07140">
        <property type="protein sequence ID" value="AFK07140"/>
        <property type="gene ID" value="Theba_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1454"/>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030708_3_0_0"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="494" mass="54710" checksum="E3EF7DF1B01C08D2" modified="2012-07-11" version="1" precursor="true">MFLNLLKQRYRLVFGYLGNLFVFFPIVLLIPLLYCIWNPEDFLQSLAFVEAASISFVIGMTLKLTMKVRPGSPISVQEGAIVVLFSWVMAIILSALPFIFAGYFNFTQAIFESTSGWTTTGLTLADVETIPGTFLLWRSMMQYLGGAGIAIIMMSAILGPAGLGLYKAEGRMDNLVPNIKSSTRTITTIYGSYAVAGIIMYRIAGMNLFDAINHSLTALATGGFSTKAGSIAEFNSVSVEIVTIVLMLLGATGFGIHYTIWKRNFRAFWKNGEPKLMFVILAIFTPLLMTGTLSIFYSSGAEQFRHSVFQAVSALTGTGFSTVDLVPWNHFGIYLVILLMIFGGDLDSTSGGLKQYRLFALLKILWLEIRRYFLPKDAILKEEIWKGETKRYIDNSLVKEILLVFSLYFLTYAIGTGVLMAYGHSMAFSAFEYASALSTVGLSVGITAPNAPAGLIWAETIGMFLGRLEFLVVIYAITKLMRDGRILLRRRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G6</accession>
    <name>I2F5G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">Theba_1487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731100.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1487"/>
    <dbReference type="EnsemblBacteria" id="AFK07169">
        <property type="protein sequence ID" value="AFK07169"/>
        <property type="gene ID" value="Theba_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1487"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_1_0"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="308" mass="33920" checksum="D4EBB14C76502740" modified="2012-07-11" version="1" precursor="true">MHREVFTFLLAFLLSVLAIEPLKRYQKRRRIGQYIREEGPDLHNYKTGTPTAAGIVFIPIALAVASIFAFRAEILIVVIAGILFGLIGLVDDISKIVKRNASGLSGKRKLALQLVSAAFIVFLIQLVNPHTHIEIPFLGKIGLGFAYYPISALIIAGMSNAVNLTDGVDGLAASVYIFSLAPMLALPVWQNGLIAPISGALAGFLWYNWFPASIFMGDTGSLSLGGIMAVIFALDGREGFLIFFGLMFLVEMFSVIIQVFSFKVFGRRVFKMSPIHHHFELSNWKESKIAFRFSLIAFIGAVFGLLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G7</accession>
    <name>I2F5G7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ORF">Theba_1488</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1488"/>
    <dbReference type="EnsemblBacteria" id="AFK07170">
        <property type="protein sequence ID" value="AFK07170"/>
        <property type="gene ID" value="Theba_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1488"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="114"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="116"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFK07170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="441" mass="49222" checksum="AB2A1792A9D9993B" modified="2012-07-11" version="1">MLEGKIGLVGFGVSNEKLLERLVKDRDSKSLFVSDTGKIKEEGRTLLKKFDIEYEEGGHTDRLFDCDAFIVSPGVSPFSEVGERIIHSGKYYTTELEVSLDELWSKPRGTVIGVTGTNGKSTTVTMLRHIISGKNRKVFQGGNLGYPLAGVAEEVYDYYVLEVSSFQLKWFAEERVRFHLSAVINLGEDHLDYHRSIDDYFKSKLRLAKMTEGITVVPKAVADCQKELLKGSKLRPFVALGEGFDSFDREHLRVRGIEFRTSDLPFTGLHNYENVLVVLLISQLIGLSAEDVFQELKSYTFLSHRLQLVRELEGVKYYDDSKATNAHAVSAALRSFEPSKTILILGGREKDETYSELIEQLGQLKHVVMLGSSMKILSAKLQMRGIPVSGAANMADAVKICRGLAAKGDNVVLSPAGSSYDLYINYSERGNHFREIVTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H5</accession>
    <name>I2F5H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAO/AO transport system ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731106.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1496"/>
    <dbReference type="EnsemblBacteria" id="AFK07178">
        <property type="protein sequence ID" value="AFK07178"/>
        <property type="gene ID" value="Theba_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1496"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_1_0"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="31427" checksum="EC3725361FB3B752" modified="2012-07-11" version="1">MRSMELKIDQLKVSRVLSIIENNTDEARKIIDKLPQRDYFVIGVTGSPGAGKSSLTDRLACMSAVEKSTAVVAIDPSSPFTGGAFLGDRIRMRRATDDPGIFVRSMASRGNVGGLSPSIYNTVEFLGRSGYDWIYVETVGAGQSETDIANLADIVVLVLAPGLGDDVQTMKAGIMEIGDIFVVNKSDLPGSDQLFSRTRAILELSGKQLPVVRTNSIKGNGIEELHKKIEEILEDYINSGRLSEKRRKRNLYNNLNSAYQIIKEHYAENAKLEELIKYLLENIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H6</accession>
    <name>I2F5H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="3">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731107.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1497"/>
    <dbReference type="EnsemblBacteria" id="AFK07179">
        <property type="protein sequence ID" value="AFK07179"/>
        <property type="gene ID" value="Theba_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1497"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_0"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="135" mass="14885" checksum="7F0295128ABFD97E" modified="2012-07-11" version="1">MRSDKIDHIGIAVRSIEERLSVYRDLLKLELTGIEELPDRGLRVAFVKAGDTRIELLEPISEDSQISKFLESRGEGIHHIAFHVDNVEGAIEEAVSLNLKPLSKEAEIGAGGTRVVFLHPKSTGGVLMELVEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K8</accession>
    <name>I2F5K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sterol carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487132.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1535"/>
    <dbReference type="EnsemblBacteria" id="AFK07211">
        <property type="protein sequence ID" value="AFK07211"/>
        <property type="gene ID" value="Theba_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1535"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_1_2_0"/>
    <dbReference type="OrthoDB" id="1982614at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="104" mass="11275" checksum="DAC697D5E2EAF177" modified="2012-07-11" version="1">MTVREAVCKIKSLRAERLSEISGTYMFFIAGGEPSKFAVEILDGRLEVYEEDKPSDCSISTDLETFEGIVGGAVNPFAAFMSGKLKISGDLTFAMKLNKLLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L4</accession>
    <name>I2F5L4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">Theba_1541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731129.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1541"/>
    <dbReference type="EnsemblBacteria" id="AFK07217">
        <property type="protein sequence ID" value="AFK07217"/>
        <property type="gene ID" value="Theba_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1541"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_2_0"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="163" mass="18566" checksum="FA2B290FC072D086" modified="2012-07-11" version="1">MKVIYIGNPILRDVSEKVEVFDDELRQFVNELSKTMYVEDGVGLAAPQVAISRRLFVYDPGDGLRVVVNPEILFRSDEKVKIEEGCLSIPGIYADVVRPASVRIRYQDEYGHYHEDDLTDYPARIVQHETDHLDGILFVDYLSSAKRAILKPKLDQIIKESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N3</accession>
    <name>I2F5N3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487176.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1564"/>
    <dbReference type="EnsemblBacteria" id="AFK07236">
        <property type="protein sequence ID" value="AFK07236"/>
        <property type="gene ID" value="Theba_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1564"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_4_0_0"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="47"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="278" mass="31293" checksum="70456404FF9C1DD8" modified="2012-07-11" version="1">MRVLFLGTAAYEGHPNVFCDCDNCRKVREAGPDNFRLTSAVLVNDDLLIDFGPNIMAGAQKTGSTLFNVRTLLITHSHSDHLYLPNFGYRMDRYNASYERLSPMSVLANSTVLSLISDSVYFDPDKTILLMAEAYKETVLNDYSVIPIPAVHKVKEGEQALLFLIKKKGKSFFYATDTGPLDEFSLKLIKSFLDSPLDLVAIDSTLGFMKEVTFPYHQTAEQVVSTVETMRKNGIMDDTTKIYAHHFSHYPNPTQGELERFYVRFGIAVAYDGLSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q1</accession>
    <name>I2F5Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1584"/>
    <dbReference type="EnsemblBacteria" id="AFK07254">
        <property type="protein sequence ID" value="AFK07254"/>
        <property type="gene ID" value="Theba_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1584"/>
    <dbReference type="HOGENOM" id="CLU_3170081_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="47" mass="5571" checksum="D2D99591C342A97A" modified="2012-07-11" version="1">MTYLYIAIAVYLSSVLIYNAYKSAKKWEWVMSAMILIPQILRIFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S7</accession>
    <name>I2F5S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731179.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1616"/>
    <dbReference type="EnsemblBacteria" id="AFK07280">
        <property type="protein sequence ID" value="AFK07280"/>
        <property type="gene ID" value="Theba_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1616"/>
    <dbReference type="HOGENOM" id="CLU_1545826_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="173" mass="19346" checksum="06B20B6A58D633D1" modified="2012-07-11" version="1">MVYSIKRRDDGSFVAYMKGVLFSKDGDSWYLPSPEEFKEIGDLEVNGTLVFEKTDEIEDDSPKFSDLCGLPLLSLEEALLSAGLAFETTGNNIAISCKDNHKLEVLSYEDLLLIVFCPECKTGILNFISFLDATGVGNDLFQPDCNYDEVWLPMNEETYQKTVEALSSVINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F643</accession>
    <name>I2F643_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731262.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07396">
        <property type="protein sequence ID" value="AFK07396"/>
        <property type="gene ID" value="Theba_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1740"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_1_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="49026" checksum="78CE3912CB0C3711" modified="2012-07-11" version="1">MKYYSLIDKVYLEKNLLEAYGRVKSNRGAPGIDGVSVEIFAEKLPEEIERLSGEIKRGEYKPMSLRGVEIPKADGKTRQLRIPAVRDRVVQQSLKEVLEPIFEEGFHPSSYGYRKGRNAWQAVEKAKAFASKYGLCNVVELDLSECFDTLDHEKIIDSVAERVSDGKILKLIRAILKSGVMEDGVWKETETGSPQGGVISPLLANIYLNEFDQKMKARGIRIVRYADDILIFSKTQEEAREFLAIAINILEIDMKLKVNRNKTRITTLEDGFHFLGFEIKGERVGIEKSRLKRFKEKVRKLTRRNQSRPVKEIVKQLNPLLRGFASYFRIVDFQSILRGLLSWIRRRLRAIILHQWKTTKKLNRVLRRTGWKEKVNMRMNKWRSSHSKAANYAIPNRFFEEMNLVDMTKYHHPLSKFPILDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F684</accession>
    <name>I2F684_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489193.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1786"/>
    <dbReference type="EnsemblBacteria" id="AFK07437">
        <property type="protein sequence ID" value="AFK07437"/>
        <property type="gene ID" value="Theba_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1786"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_1_0"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="36606" checksum="BF7D0D7FB4F8DE45" modified="2012-07-11" version="1">MRDRSKPVLCSGEILFDFISREPMKGLEGTTLFEKKPGGAPFNISVGLHRLGVPMEFLAKIGMDEFGNALLEYLKSLGISTSYVIREHGTKTPIAFAALDGEGKPEFRFYWDHAAHLSLKSEEIEEIDPLNFSLFHFGAIVLLEEPSASTYLELFERFSSRGVKTSFDPNIRRSAIEDHDSFRATVREIISRVDILKLSDDDLLYICDSDNLDEALSRLKVRPDTLVFLTLGSRGSTVYRGRTSVKREGFKVKVAETTGCGDSFMAAVISKLYNMGDEELRSLTEEDLGSILTFANAEAAIVATRYGGASSMPAESEVNQFLKERGMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F689</accession>
    <name>I2F689_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Entner-Doudoroff aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731273.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1791"/>
    <dbReference type="EnsemblBacteria" id="AFK07442">
        <property type="protein sequence ID" value="AFK07442"/>
        <property type="gene ID" value="Theba_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1791"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_1_1_0"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="23018" checksum="5A3D1C21F2BF7502" modified="2012-07-11" version="1">MFERLMTEKVLTVIRGLTLDQSRKLCEMLLENDLTILEVSFSDESSSEILHELKKEFYGKLVIGAGTVYDDTAYSRALRSNADFVLSPGFSEEIAKLSTRDGISYIPGVYTSTDIQTALNNGFSFLKLFPGDAEGLNLLKAYRGPFPTVKFMPFGGVTAENATEYMKAGAVALGIGSYIANRNLFDEEREGEVLERILKIRRAVNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F8</accession>
    <name>I2F6F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein (DUF2078)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1861"/>
    <dbReference type="EnsemblBacteria" id="AFK07511">
        <property type="protein sequence ID" value="AFK07511"/>
        <property type="gene ID" value="Theba_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1861"/>
    <dbReference type="eggNOG" id="COG3462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2862627_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="64" mass="7538" checksum="FFFDBE0CD28146EE" modified="2012-07-11" version="1" precursor="true">MMFFGFLIVIFAVAFFLKPDILKSRMTISSSYDKEMRVLRERLANGEISIEQYEQLKKALSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G1</accession>
    <name>I2F6G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(P)ppGpp synthetase, RelA/SpoT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488309.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1864"/>
    <dbReference type="EnsemblBacteria" id="AFK07514">
        <property type="protein sequence ID" value="AFK07514"/>
        <property type="gene ID" value="Theba_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1864"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_0"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="53"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="394"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="725" mass="83115" checksum="CF0C91B51DB5524C" modified="2012-07-11" version="1">MARTEIDAQILLGDLESILQYRLKRRDKERIFDAYEFARFHHQEQMRDSGEPFISHPIEVAKILAQFSADNDTIIAGILHDIVEDCNVPLSEIAEKYGDTVALIVDGVTKISNLKLNEKLESKIVKSRMKVETLRKMLLALSDDPRIIIVKLADRLHNMRTLDFLKDPEKKRDKARETLQIYAPIAHRIGMHKIQAELEDLSFKYEYPEEFKELKFKVNRKLKERQDIMDEYKEIVLRELRKNRISALIEGRVKHLYSIWQKMIKKNRSFDEVFDLIALRIVTGDEVNCYKILGAVHSLWPPMPGRFKDYIAAPKSNGYKSLHTTLITHRGEPLEIQIRSERMHKEAEYGVASHWVYKEGIDVKDRTWFTQLVDWQKDFIESFKDMESISRELEVEEVFVFTPKGEVVHLPKGATPIDFAYAIHTEVGHHYAGAKVNDRLVPVNYELQLGDRVEVIVNKASEGPSLDWLKYVRANSTKAKIKRFFKNEYSAKLVERGKEIFRKISKRLAVSMDDLIEGEQIKALMNRLGAHNENDLFSKLGDGSVTMGEVLSLLAPKEEEIETLPEETELIKQKQAKGNEVVVGGETGIAVYFAKCCTPLPGDDIVAVMSSRGISIHTRNCRNLKGISKDKLVEAHWNLDTGGKFSSWIVVEFDSADRTIVNKSLERLENKNAKVMKYSVEAGRWGYDTLIANILVKDVAHLTSVMENLRGMKGVQNVKRYGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K7</accession>
    <name>I2F6K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ORF">Theba_1913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731362.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1913"/>
    <dbReference type="EnsemblBacteria" id="AFK07560">
        <property type="protein sequence ID" value="AFK07560"/>
        <property type="gene ID" value="Theba_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1913"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_3_0"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="20911" checksum="70DDAA92BB65080E" modified="2012-07-11" version="1">MDYNIYSKDVTVTDSMKDYIDKRFSKVSKVVNEEKLISMDLRLSKERAFYKIEATAHLPGVMVRVEEKGSDFYTVVDSSSDAFERRIKRFKERTRYKHKNGFKENLDSIPSKFEEDHSTMITRRKKFTIKPMTEEEAVLQMEMLGHTFFVYRNIDTDEVNVLYTRKNGSIGIIEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L5</accession>
    <name>I2F6L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MORN repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731370.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1921"/>
    <dbReference type="EnsemblBacteria" id="AFK07568">
        <property type="protein sequence ID" value="AFK07568"/>
        <property type="gene ID" value="Theba_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1921"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936298_0_0_0"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="297" mass="33686" checksum="31F5A34E15AEAEAA" modified="2012-07-11" version="1" precursor="true">MKRISLFLVLLVFSVIALGQSEFMIPMSTEDFGLRGPVKSAKILYPENEMDLGVDEELVLSGYSVLFFNENGSLVSQIEYDKDGNEQSAILFNYDSNGKLLSVSGRENGVEENVDEIKVENGRIAGIVVEDSEGDSNLIMEYDEAGRLIAQKISGMSEGQKIEMTISMKYDDNGNLIEESFGMMGMVMTKTVFEYNAKNQSIRELEYMYMFAEPGSEPEPIESILEYNEMGDVVLRISDSAFGEEKEAVVYEYEYDSMGNYMHKVGYYVMNAADLEKETWKETATVEEEETREIEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M4</accession>
    <name>I2F6M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small redox-active disulfide protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731379.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1931"/>
    <dbReference type="EnsemblBacteria" id="AFK07577">
        <property type="protein sequence ID" value="AFK07577"/>
        <property type="gene ID" value="Theba_1931"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1931"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_18_2_0"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005243">
        <property type="entry name" value="Redox_disulphide_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36450">
        <property type="entry name" value="PTHR36450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037031">
        <property type="entry name" value="Redox_disulphide_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00412">
        <property type="entry name" value="redox_disulf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="8352" checksum="ED96D8995B11B8EB" modified="2012-07-11" version="1">MKIEIFGSGCPRCKQTEKIMKMAVEELDSDAIVEKVTDMMVIMEKGIVSTPAVAVDGKIVISGKIPSLDEAKRLIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U1</accession>
    <name>I2F6U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488050.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2001"/>
    <dbReference type="EnsemblBacteria" id="AFK07644">
        <property type="protein sequence ID" value="AFK07644"/>
        <property type="gene ID" value="Theba_2001"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2001"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_0"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="36189" checksum="2E7AD0E41956DCFA" modified="2012-07-11" version="1">MNESLLDELNEAIIMVDEGLVVTRANLSARKMLGDVEGLALPDALHVQGISKIVDNLISGTNYTIDTIFVKDDTTHYLKIRVSAPYIIARNITSEKLFESAKMDFVNSIVHEFSTPLAVINGYVQLLIEKKMELPADVSETIERIARSTGRLSRLVEELGILSNLELQNYRVKIETVNLKELIDESVSDLESKWKRKKLKITTTVSPNTYAAVDSLLLFRVISNLISNAVKYSSVGDTIEIVSREVESRIYISVKDNGIGIKSEELPRIFERFYRGSNARTSGSSGLGLGLSLVKHALNLINGSIEVRSRYMMGTTVTISFPKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F743</accession>
    <name>I2F743_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731520.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2112"/>
    <dbReference type="EnsemblBacteria" id="AFK07746">
        <property type="protein sequence ID" value="AFK07746"/>
        <property type="gene ID" value="Theba_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2112"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826176_0_0_0"/>
    <dbReference type="OrthoDB" id="1083526at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="343" mass="37147" checksum="15A80834FDE68954" modified="2012-07-11" version="1">MKGCPYGSHRVIEPAGFLPQAALRIDNSLDLYDNEILVDVTTLNVDSASFTQIREACEDDVTKISSMIMDIVRERGKLQNPVTGSGGMFIGKVSKIGKDLLRRDLEIGDTIASLVSLSLTPLNIERIVQVHLEKDQIDIEGKAVLFESGIYARLPSDIPPKMALAVLDVAGAPAQVDKLVKKGMNVAILGGGGKSGLLCCYAAMKKCRDSGKVVVVEYSVENAERIRKLGLAHEVIIADATKPLEVYEKITEFTQGDLCDVVINNVNVPGTEMGSILCAKDNGIVYFFSMATSFTRAALGAEGVGKDITMMIGNGYTKGHAEFALGILRESSEIRRLFQKLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F777</accession>
    <name>I2F777_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731548.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2147"/>
    <dbReference type="EnsemblBacteria" id="AFK07780">
        <property type="protein sequence ID" value="AFK07780"/>
        <property type="gene ID" value="Theba_2147"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2147"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228727_0_0_0"/>
    <dbReference type="OrthoDB" id="2072989at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="26876" checksum="FB83B62DEB3FFAC5" modified="2012-07-11" version="1">MSREMRIMWLHNRLLKNDFAAMKDYTQKFGISVRQAHRDFKYLRANLGAPMKYSRKRGEYFYSEPYHLPSLFEDSMKFQLRTEYRISSVFLNAIASKKAVKIFQRGGKEFIFYPACFDERRELFCGLQEDGNVRFVRSDEIDKVIFSNKRYLEEPMLWNRIFPREAEFHEVDLDFGGDRHKYHFFEIGDLVMFLASENSFKVIGPQEIIDELRKVAENLLKTIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F780</accession>
    <name>I2F780_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2150"/>
    <dbReference type="EnsemblBacteria" id="AFK07783">
        <property type="protein sequence ID" value="AFK07783"/>
        <property type="gene ID" value="Theba_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2150"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168035_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024227">
        <property type="entry name" value="DUF3795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12675">
        <property type="entry name" value="DUF3795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="114" mass="12840" checksum="E9DD028C66C14C82" modified="2012-07-11" version="1">MIAFCGIDCSQCDTYRATIADDNSLRRETANRWSVDFGFDISSEDVSCSGCHGNSLFKLCSGCPFKLCCEEKGISNCGECEEYPCETLERFLKALPNARRRLDSIHEKCYHTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F785</accession>
    <name>I2F785_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731556.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2155"/>
    <dbReference type="EnsemblBacteria" id="AFK07788">
        <property type="protein sequence ID" value="AFK07788"/>
        <property type="gene ID" value="Theba_2155"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2155"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="318" mass="36159" checksum="5BD9331B7387DE04" modified="2012-07-11" version="1" precursor="true">MEYRKVGKSGLLVSELSLGSWLTFGAQLDIDNAREAMREAYRAGINFFDTAEAYASGMAESMMGEILKEFKREEVVVSTKIFWGGNKPNQKGLSRKHLLEGTWNSLKRLQLNYVDILFAHRPDPEVPVEEVVLGMDYIVRNGLAFYWGTSEWSSKELEEAHKVADRLNAIHPVVEQPQYNMFVRERVESEYRPIYEKYGLGLTVWSPLASGLLTGKYNKGIPEDSRLAKFPGLKKHLEESKLFSSENLKKVERLAAVAKKLDTELAQLALAWILKNENVSSIILGVSKVQQLRDNLKALDVKDKLTEEITKEIYSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A3</accession>
    <name>I2F7A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731571.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2173"/>
    <dbReference type="EnsemblBacteria" id="AFK07806">
        <property type="protein sequence ID" value="AFK07806"/>
        <property type="gene ID" value="Theba_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2173"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_0"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="19604" checksum="15621E6E438890BC" modified="2012-07-11" version="1" precursor="true">MSPLRLFWIFVKVSTFTIGGGYAMIPVIKEFIVDKYRIIKEDEFLDVIVTAQTVPGVIAINTAMILGSRLAGFWGAFFAVLGASLTPFIIILVIASFFTDFVDLPVFKGFFAGARVGVTVILANLSFQLLRKSLRRYLIVIVIAAGTLVIVFLNVSSILVLLVCSLLIYFIDRRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E7</accession>
    <name>I2F7E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">Theba_2219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731609.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2219"/>
    <dbReference type="EnsemblBacteria" id="AFK07850">
        <property type="protein sequence ID" value="AFK07850"/>
        <property type="gene ID" value="Theba_2219"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2219"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_0"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="480"/>
            <end position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="540" mass="57670" checksum="F93A60B094C9B2B3" modified="2012-07-11" version="1">MAKILKYSEEARRSLEKGVDAVADAVRITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIDLEDKFENLGAQLVKEVASKTNDIAGDGTTTATVLAQAMIKEGLKNVTAGANPILMKKGIQKATEKAVSHIRSLSKKISSREDIASVAAISANDSEIGELIAEAMDKVGQDGVITVEDSKTLDTYVEFVEGMQFDRGYISPYFVSDPEKMEAIIKEPLILITDKKVSAVKPLVPILEKVAQAGKPLVIIAEDIEGEALSTLVLNKLRGTLDSVAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLENATIDDLGSAGVVKVKKDDTIIVDGKGDPEKIKQRIGQIKVQIDQTTSEYEKETLQERLAKLSGGVAVIKVGAATETELKEKKHRIEDALSATRAAVEEGIVAGGGVVLARAKKPVQELFDSTENPDIKIGIKVVMKALDAPIRQIVENAGLDGAVVVDKILHSDDAAFGYDALNDVYTDMFKVGIIDPAKVTRSALQNAASIAGILLTTEAALTEKPEEKPQAPMPQMPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E8</accession>
    <name>I2F7E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731610.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2220"/>
    <dbReference type="EnsemblBacteria" id="AFK07851">
        <property type="protein sequence ID" value="AFK07851"/>
        <property type="gene ID" value="Theba_2220"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2220"/>
    <dbReference type="eggNOG" id="COG5421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031289_3_0_0"/>
    <dbReference type="OrthoDB" id="995276at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="527" mass="62031" checksum="A16B2775A8B8EA35" modified="2012-07-11" version="1">MGIVYQKNKKTGITYVYKNEAYWDKEKQQSRAKRTLIGKLNTSTGEIVPTRSYRKDSISKKPGPVPITKIRRDFYGACYLLDQVGKITEVEADLKACFPDRYRMILSVAYYLILEENNSLSRFSRWQRLHAHPYGEDIPSQRGSELFQSISEEERMMFFKKQGRRRIEKEYWAFDITSISSYSETLSQVKKGRNKEYDRLPHINLALLFGEQSGLPFYYRKLPGNITDVKTVKQLMAEFNVMGYKKVSVLLDRGFYSRENINLLFKNHQKFIIGVKLNLNYVKETLEEERDNLQLWSNLQPQFGVYGLCRTTQWEYEQERPNKGDVLSSKRRAYLHLFYNGEKAARDQAEMNDYLSRLYNDLVNNTREEYRMKDYDKYFTVTSKFRKITPKEEAMREAARNYGYFALLSNEVKDPFEALSLYRSKDIVEKGFGNLKDRLNFGRMQVSSELSLNGKLFVEFVALIYLSYIKKKMQDTCLLENWTLQGLLDELDTIERFESPEHGRMIGEVTKKQEEIYAKLGVKSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G7</accession>
    <name>I2F7G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731629.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2240"/>
    <dbReference type="EnsemblBacteria" id="AFK07870">
        <property type="protein sequence ID" value="AFK07870"/>
        <property type="gene ID" value="Theba_2240"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2240"/>
    <dbReference type="eggNOG" id="COG5421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031289_3_0_0"/>
    <dbReference type="OrthoDB" id="1921444at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="535" mass="63181" checksum="78408FD720ED6EA4" modified="2012-07-11" version="1">MGIVYQKNKKTGITYVYNNQAYWDKEKQQSRAKRTLIGKLDPDTGEILPTRSYRKDTEQKDSISKKPGPVPITKIRRDFYGACYLLDQVGKITEVEADLKACFPDRYRMILSIAYYLILEENNSLSRFSHWQRLHVHPYGEDIPSQRSSELFQSISEEERMMFFKKQGRRRIEKEYWAFDITSISSYSETLSQVKKGRNKEYDRLPHINLALLFGEQSGLPFYYRKLPGNITDVKTVKQLMAEFNVMGYKKVSVLLDRGFYSRENINLLFKNHQKFIVGVKLNLNYVKEIVEEERENLQLWSNLQPQFRVYGLCRTIQWDYEQERPNKGDVLSSKRRAYLHLFYNGEKAARDQAEMNDYLSRLYNDLVNNTREEYRMKDYDRFFTVTSTPKRGRKVTPKEEAMREAARNYGYFALLSNEVNDPFEALSLYRSKDIVEKGFGNLKDRLNFRRMQVSSELSLNGKLFVEFVALIYLSYIKKKMQDTCLFENWTLQGLLDELDTIERFESPEHGRLIGEVTKKQKDIYVKLGVKSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G8</accession>
    <name>I2F7G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07871">
        <property type="protein sequence ID" value="AFK07871"/>
        <property type="gene ID" value="Theba_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2241"/>
    <dbReference type="HOGENOM" id="CLU_3329963_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="38" mass="4174" checksum="7DE86488CE826DBF" modified="2012-07-11" version="1">MRLLVFNGSPREVKSNTLTIVTCTPGNYNEGDFTPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I5</accession>
    <name>I2F7I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2259"/>
    <dbReference type="MEROPS" id="T02.002"/>
    <dbReference type="EnsemblBacteria" id="AFK07888">
        <property type="protein sequence ID" value="AFK07888"/>
        <property type="gene ID" value="Theba_2259"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2259"/>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="307" mass="32728" checksum="652E3BF82A6D50BF" modified="2012-07-11" version="1">MAVEDFAGGNQLKRALIVHGGCDEGFLPQKEMELRTQGVNVAFEIGLEVLKGSDSALDAVESVIAKLEDDPHFDAGISGSFANMIGEIEMDASIMDSNEAAGAVIRIKNFAHPISVARKVLEEIPHLMLSGKGAELFARLMGFRETSPNEQYANTDDREIEKLPEDYREFVRKYSKLLAEQRTFSTVGAVAIDSKGHIVAGTSTGGIAHAFPGRVGDTPIIGAGTFASRSAGASATGLGEGILRVGVTRKLVELVEGGQAVQEACDRVVEICSERGFQCGVIALDAEGNAGLSHNGFFMPTMYSRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T3</accession>
    <name>I2F7T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731733.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2365"/>
    <dbReference type="EnsemblBacteria" id="AFK07986">
        <property type="protein sequence ID" value="AFK07986"/>
        <property type="gene ID" value="Theba_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2365"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="37553" checksum="7854650AF1698AAE" modified="2012-07-11" version="1">MKKNYATIKMIAEDLNLSTSTVSRVINKHPDVSQETRRRVLKKIEELGYVRNATATLMRNNVSTTIGVIFEAEYDPFFSEILQGIEKGISKYNYRMILINTKLRSAEARSAVNMLLEHRVGGIIIVPSNPEISYAKDLVKRQFPVVVIGRDYKELDVDEVFTDDYHGGELAGEYLVSRGATRLLMINSRDSGSASSEREKGFVKIAEDKKVYYEVINDRVTDYDNTFKIVRSIFSESIPFDGIFCFNDTRAFAAINALRSIDESLLRKISVIGYDDIIFSSIFSPKLTSIRIDKDMEGFEAVKLLDQRIRGVRKSVKREVLNVSLVIRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V5</accession>
    <name>I2F7V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731750.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08008">
        <property type="protein sequence ID" value="AFK08008"/>
        <property type="gene ID" value="Theba_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2390"/>
    <dbReference type="eggNOG" id="ENOG50345U0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1784594_0_0_0"/>
    <dbReference type="OrthoDB" id="2008378at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="145" mass="15715" checksum="FEDF284EF8004A16" modified="2012-07-11" version="1" precursor="true">MTKMICVFLVLILAVSMIGVDFSVGVKIHGHFEPFVAVNFDTWLLGFQVKAGVIFATDSIVLVPGLYLYKDIASWRVHGGVEGLIHLGEMECLMLAGAGASYGFKTDFGRVLVGGELGLPISLPGDFFVDATMKLVPTFLIQLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V9</accession>
    <name>I2F7V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2394"/>
    <dbReference type="EnsemblBacteria" id="AFK08012">
        <property type="protein sequence ID" value="AFK08012"/>
        <property type="gene ID" value="Theba_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2394"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_3_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="167" mass="18198" checksum="4458562CAE48993E" modified="2012-07-11" version="1">MKSKKPLKTNATRILDGLGIEYEILEYEVDEHDLSAENVASKLGLSPSRTVKTIVLKGDRSGVFVCCLGGHREIDMKKLPEITGDGNIETVPSESLLTLTGYVRGGVSPLGMKKSFKILVDKGVLNEERISVSAGKRGLQIWLRPTDLVCATNASVVSFSKEKHQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W3</accession>
    <name>I2F7W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Co/Zn/Cd cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731758.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2398"/>
    <dbReference type="EnsemblBacteria" id="AFK08016">
        <property type="protein sequence ID" value="AFK08016"/>
        <property type="gene ID" value="Theba_2398"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2398"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_6_0"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="8">
        <location>
            <begin position="215"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="34551" checksum="51B2658BD16EE87D" modified="2012-07-11" version="1" precursor="true">MTEDRMVLSRRGSIIGVTGNAALAVLKVLTGFFTGSMAILADGVDSTTDILTSVITWISTSVSNKPPDAQHPYGHERADAVASKIVSMVIFFAGAQLAVSSIQKLFSGGSSVENIALVIVVAAISSAAKYFLYRYKLGIGKKIDSSVFIADATNMKLDIVISLSVLGGSIFVGITGLQIVDSIVGLAVSALVIKTSIEVFWETNYELMDGLKPGDDIYKVVFDSIERVQGVQNPHKVRVRKMGYKYLVDLDIEVDPDMSVKKAHSLAKKVEASIKEDHKNVYDVHVHVEPSGNVEDENFGIDSSKEFNESLNNKDEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z4</accession>
    <name>I2F7Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731785.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2432"/>
    <dbReference type="EnsemblBacteria" id="AFK08047">
        <property type="protein sequence ID" value="AFK08047"/>
        <property type="gene ID" value="Theba_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2432"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_2_1_0"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="242" mass="28338" checksum="EC4D05FF9C6D7EA2" modified="2012-07-11" version="1">MAETPIPLYYKLYMDLKESLNSGKYQKGDKLPTEKDLCQKYSISRLTVRRAMDELRREGVIERLKGKGTFVTGSKREEQLAILTGFTDEARKRGVETRSVVLENRLVRVPADAVELFDIPADAMVVLLKRVRILEGEPYAIEEAYLNVGADIRLLNITQRDMERESLYGILRKEFEINISYAEEEMELTRLKKEEARFLRQEQDDCAIMRKRFTYTKSDICIEYVISLYRADKSKFKIVRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F821</accession>
    <name>I2F821_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731806.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2463"/>
    <dbReference type="EnsemblBacteria" id="AFK08074">
        <property type="protein sequence ID" value="AFK08074"/>
        <property type="gene ID" value="Theba_2463"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2463"/>
    <dbReference type="eggNOG" id="ENOG503025Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785754_0_0_0"/>
    <dbReference type="OrthoDB" id="1666377at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="149" mass="17084" checksum="51B551F5AB37AE25" modified="2012-07-11" version="1" precursor="true">MKCPECYSSDNRATPLKNPEDCLSNHVQYICSTCGRAICMEGDEREKHGPLSSFGSFNDAMLYLRAAEALFNGPCGIYELTDGAKVFYKIFKDKDGLMNYLLENPEKRCPLGEALHETEEFRPVVEGQIRRLDKEEVEEYLREKEEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F822</accession>
    <name>I2F822_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731807.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2464"/>
    <dbReference type="EnsemblBacteria" id="AFK08075">
        <property type="protein sequence ID" value="AFK08075"/>
        <property type="gene ID" value="Theba_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2464"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045354_1_0_0"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030192">
        <property type="entry name" value="YbdG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30414">
        <property type="entry name" value="PTHR30414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="442" mass="49843" checksum="AE79303D838F6452" modified="2012-07-11" version="1">MIDIFAGWFSALGLSETFDLVLANIVVGIIMVVVAFLSKFLFEKLLIKPIEIIVRRSAFKWDDYLIKHRLLYKIALMIPAIVIALFARAFPAIEDLIYKLVATYLIFIVAVVIDSFLDVLTSAYQSLETSKDKPIKSYITVVKIMVYIVAGVIAVSVLTGISPWGILSGIGAMTAVLLVVFRDSLLGLVASIQISKNNLVSIGDWIEVPKFQADGDVIDITLTTIRIQNWDKTITTIPSYAIISESFKNWKGMFQAGGRRIKRSVFIDTSSIRFLDDELYERLYRIEILRPYLESKKKEIEEFNKKNNVDVSEPVNGRKMTNIGTFRAYLMAYLRNLPGTNKNMIIMVRQLQPTDTGLPLEIYAFSSDTSWVNYEALQSDIFDHVFAALPHFGLRVFQNPTGRDVRALGELFVSGKMAVPHPSAGEKSATINNDEDRQIDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F832</accession>
    <name>I2F832_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731817.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2474"/>
    <dbReference type="EnsemblBacteria" id="AFK08085">
        <property type="protein sequence ID" value="AFK08085"/>
        <property type="gene ID" value="Theba_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2474"/>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_0_1_0"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657693" description="Glycoamylase-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoamylase-like" evidence="2">
        <location>
            <begin position="188"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="418" mass="47615" checksum="C5AAC61A58273A8A" modified="2012-07-11" version="1" precursor="true">MKNLKSCLTALLILLCVFATGSQNLEREYKGSFYYFWEQTNTLDHSPGYGLVRDRFPGNPSIASIAAVGFGLTAIPIGVEEGWISYEDGFERASRTLDTFLKLENFHGFFFHFLDFNTGERAWDCEISTIDTAIFLCGALTAGEYFGGEVAEKASALYERVNWNRMIDYRNNYFYMAYYPEKGFQGFWDFYAEQLMMYVLAAGAPNPKYRIDPVVYYSFKRYEGSYKGERFIHSWFGSLFTYQFSHAWIDFRKIRDRDGIDWFENSIRASLANYNYCKDNADQYTGFVIGWGVTACDGPGGYNGLLGTPPSGNNSTAHRVDGTLAPAGALGSIVFLPDRSLEALEAYYELPDLVGGYGLKDSFNLDLDWFASDYIGIDKGITLLMISNYRNDLVWNILMESEYIVDGLDRLGFEVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F883</accession>
    <name>I2F883_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731861.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2532"/>
    <dbReference type="EnsemblBacteria" id="AFK08136">
        <property type="protein sequence ID" value="AFK08136"/>
        <property type="gene ID" value="Theba_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2532"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650439_0_0_0"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657825" evidence="1">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="450" mass="50759" checksum="50E6B3B0D9A2C8EA" modified="2012-07-11" version="1" precursor="true">MKKLSVLLIALIALFGVTALSTETMVCTYAQMANDFFLTFDKGAREAVEALGNMYIAASDDRSPEKFLFQIESFAAAGVKMIFGYSPTIESVIQASNFVNREKVYYANILEIADWWTPLDAGPYYGQFIGPDAYVDGYLGGLEMGRLLNGEGETCVLWGFPGSKAGNDRVRGYKAALMENFPNITVIGEEYADFIRDKGYSVTKDWIAKFGDRIDGIFGANTSMNVGAAIACEEAGLDHVFQVTTDANKSNLVDIKDGSLDVVAGIYGFWMAGRHAVTVYDMKNGWKPTVPETMMSTMQTFITPENVDWYIETFGKDAPYDYDWKKMSRTLHPDDWDPQGLLVPIYPERFTNWIYLDKPRGYEVPKEYKEAMESGLYQEIYELYLEKFTAAWVVPPFESSPYNYVFVANNLEEGLRADIVKRMENDVLVHEVIDVPYRFDIPDFGEGCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B3</accession>
    <name>I2F8B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine/putrescine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731886.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2566"/>
    <dbReference type="EnsemblBacteria" id="AFK08166">
        <property type="protein sequence ID" value="AFK08166"/>
        <property type="gene ID" value="Theba_2566"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2566"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_3_0"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Spermidine-binding" evidence="1">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="337" mass="38237" checksum="B29EFBE3094DAB07" modified="2012-07-11" version="1" precursor="true">MKKLTIVGAILFVSVLTLGQGNLIIYGWSDYIPSEVIEAFSKEYGVNVTYDSYDSNETMFAKIKAGARGYDLAMPSADYTSIMIKEDMLIPIDKSLIPNLVNIDPSVIEQMYYDPENTYSIPYMVGTTGIAVNTKYVESYPRSWKIFELPQFKGMMSLLDDMREVFGAALKFLGYSVNTTDTAELQAAKELILTWKENIAKFDSELFAKGVLSGEFWVVHGYGENIFYEATEEELEDIDFFIPVEGSTLWIDSFVILKGAKNIDNAHLFINYILRPDVAAKISDYLLLPSPNVPARELMEEEPVYSAKEMENTELIKDLGEDLRIYNSLWNEIRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B8</accession>
    <name>I2F8B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489459.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2571"/>
    <dbReference type="EnsemblBacteria" id="AFK08171">
        <property type="protein sequence ID" value="AFK08171"/>
        <property type="gene ID" value="Theba_2571"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2571"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071528_0_0_0"/>
    <dbReference type="OrthoDB" id="584516at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="DUF2048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="311" mass="35578" checksum="B0527B009B3186E9" modified="2012-07-11" version="1">MEKEIFAKRYSDHPEIIERLETSKGSKIFLKSNYPGEYPENGSIPLYLYEGGRKGTVLFFHGRGEKNLDYLRWFPENLAKHGYSGAMMILPFHFERTPAGHKSGELFLDPRTDVLRERFENAVVDGLTTLNYLKWECPPPYFLMGYSFGGFIAVITAALEPSISGLSLVVTGGNFYHITWKSFVTGVMRVKYEEDGSCNREKCRKLHEVDYREFLNSLQKPEIEIGSAPISCFEYDPLTYAKFVRCPTLLTGALFDIFIPRPSTRELAEMLPDATLRWMPSGHLTSILFKKTILKGSIDFFERKCKGKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E8</accession>
    <name>I2F8E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489420.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2601"/>
    <dbReference type="EnsemblBacteria" id="AFK08201">
        <property type="protein sequence ID" value="AFK08201"/>
        <property type="gene ID" value="Theba_2601"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2601"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657697" evidence="1">
        <location>
            <begin position="20"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="82"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="581" mass="65952" checksum="8E423125FEC55F56" modified="2012-07-11" version="1" precursor="true">MRRIFLLVLAVLFTAMLMAAPFVEDSMLTPDPNPRMGGTLYLALTGSPQSFNFYGTLDSNAYSVAGQMLTGLVEAHPVTSAIRPALAESWEVSEDNKEVTFHLRDVKWSDGVPLTADDVIFTFEHFVMNPVARGNSVARFTIEAKPIEWVKVDDSTVKAILPAPYAAFFTVLSHAYIYPSHALESKIDKNRPDSVNDVWLTNTPLNEIPANGPFMLSEYIIDQKVVMTKNPNYWKVDEYGNKLPYVDKIEYLVVSDAQVRLAKFMAGELDYMAVSGNDFPILKERELAGGPFRVFLAEPTQPTPSPIHIAFNFDVENPKLREVFRTTEFRQAMEYALDRERIIDEVYNGLAVLGGVPVLPSNKAFYNPKIEEIRRPFNLAEAARILDELGLKDNDGDGFREYPDGTKFEFVLTLQSSPQEYQDIAYIYSQDLQSIGVKVNLQILDSSLTGQMFGAGSFEAGIRAFGNQPDPQLRKAIWQPGTQLYYWHRTTRDPDTNLPIMENMLDWEKRVYELFEKGQVAMDPVERKSYYDEWQEIYAEYLPVIFVCKGMNLYAANKSLGNVEQNEEGLLSYSSWTVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G1</accession>
    <name>I2F8G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731922.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2614"/>
    <dbReference type="EnsemblBacteria" id="AFK08214">
        <property type="protein sequence ID" value="AFK08214"/>
        <property type="gene ID" value="Theba_2614"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2614"/>
    <dbReference type="eggNOG" id="COG1995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040168_0_1_0"/>
    <dbReference type="OrthoDB" id="1414545at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="344" mass="37324" checksum="BA7B562C523B2863" modified="2012-07-11" version="1">MILKPMEQPVLPERISDKPAIAITEGDPAGIGPEIVSKTIASGEIFEICRPIVIGEFGTLQREIDRNHLGMKIETVSEITDQTEFSPGTLSLIDMANLYRLPEYGKVDRACGRAAFEFLEKAVELAEEGRVSAITTAPINKLSIKAAGIPYAGHTEILGALTETIDPLTMFEIAGEMRVFFLSRHLSLIDACRMVKKDRVYNYILRCEAALKRLGIQLTKPIGVAALNPHGGEGGLFGSEETEEIIPAVELARKKGIDVVGPIGADSIFNMARRGVFSAIISMYHDQGHIATKTLDFERTVSITLGMPFLRTSVDHGTAFDIAGKGIADPTNLIEAVKAAARYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I7</accession>
    <name>I2F8I7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487237.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2640"/>
    <dbReference type="EnsemblBacteria" id="AFK08240">
        <property type="protein sequence ID" value="AFK08240"/>
        <property type="gene ID" value="Theba_2640"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2640"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_0_0"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="354" mass="39673" checksum="CCE56DFED4775082" modified="2012-07-11" version="1">MSRNSLKPVFIAFAKEAFRNRLEIFFTLFFPMIFLLLFGFFFGGSESYQKVSVGLYQTGPYDISAVIEESGAWNLRLYDGETDIGEAVKNGDILLGMIFNGEKITYLHQEGNLEQQSTIEMARASISAAVEKKINNARSFIVVENIPETAGRIRATDADYTMSGVIAISLLSAGMFSVISVFGRYRKRGVLDRFKITPLRPFTFVLGSTLTRFLVSLVSIVLILVVSRLLFRTTFQIDWLPFLVSILSSTLGMMALGLFLTLLFRNPETADTAASILMVIMVFLAGIYFPLSFLPDYLRVISMFLPVKYVAELIRHSLGIEFVSTSYFVITNLVLFLSGVVLLYFTGKRYLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L5</accession>
    <name>I2F8L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731964.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2669"/>
    <dbReference type="EnsemblBacteria" id="AFK08268">
        <property type="protein sequence ID" value="AFK08268"/>
        <property type="gene ID" value="Theba_2669"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2669"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060534_0_0_0"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="388" mass="44185" checksum="DECC29B24491E056" modified="2012-07-11" version="1">MRFLHCSDIHLGRRPIGSPNSPYSSARYEDYFSAFEYVVEWALQNKPEAFFITGDLFDKRDINPDTLARTQSILSRLKESGIRVLAIEGNHDKSFSANESWLRFLQETEYLELLCPVQGENDIVFPYVSIEGFKVFGLGYPGFMAEEMILRASSFLEGKDNIVLIHTAPGNDNFIPGLVSPEVLKILRSKVIYAGGGHLHSQLAFPVEEPFFFVPGSLEYWDVWERDRKGFYVFDTEIGRADFHDSHRRERQEFAVFPGEGDNLDGFVDEHEIHRGAIVLVTVTGSGEFYVDPVRLEREIESSGALKAFVRVRRTDREITLDDYRLMSARDIEREVILGSREWKELGAKGEDLVGAIEKMKQSQEDGRYDLFKESVDALLEAIVGGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M5</accession>
    <name>I2F8M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731973.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2679"/>
    <dbReference type="EnsemblBacteria" id="AFK08278">
        <property type="protein sequence ID" value="AFK08278"/>
        <property type="gene ID" value="Theba_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2679"/>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029189_1_0_0"/>
    <dbReference type="OrthoDB" id="889365at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="391" mass="42006" checksum="D9892D4AEB774E6F" modified="2012-07-11" version="1" precursor="true">METFKGYLRSDGSAGVRNHVLVLPSVLCSANVARRISSAVPGSVVASHNQGCAQLGDDFKQTRRTLINTALNPNIAAVLVVGLGCERVSPHELRDIIQDHGKPAEVIMIQDYGTVEAIERGIAIVKDMVKEASKIERKEVSLSSLVLGMECGGSDFSSGLSANPVVGQVADFLAKKKGRVILSETTELVGAEHLLFERMSDESMKQRFTKMLQRMIDESLKNSRDVVDKENVPNNISPGNVRGGLTTLEEKSLGAMIKGGKVPIVGVKEYGEVIDAEPGLYLMDTPGYDVESVTGMVAGGATVVLFTTGQGTPTGHAIAPVIKITGNRQTAKKMSDNIDFDCSAIIYGEETLEESGRKLFDLVLRIANGELTKAEVLGQDDYSIWNVGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M7</accession>
    <name>I2F8M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731975.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2681"/>
    <dbReference type="EnsemblBacteria" id="AFK08280">
        <property type="protein sequence ID" value="AFK08280"/>
        <property type="gene ID" value="Theba_2681"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2681"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_3_0"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="28012" checksum="4D1FB44AD6E632A9" modified="2012-07-11" version="1">MNRSADTNHFHGIQYQLYRSIRNSIVELEIPPGSRLTIDRLKRIYGVSSTPVRGALHKLKEDGLVAPGIAKSFYVKEILEEDVRKLFPIRFVLEKLALSESIFRIDRETISNLIVRMRKHLAEPEETKNNVPYDIDYRLHREILSNCNNEYLIEMMSKISILITRMRNVIKYYLLEQQKDWIICEMEEHFKIAQGILEGDLEKASNALETHLIHSMGMICSILGSNNVEYTARGSFVELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P6</accession>
    <name>I2F8P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731993.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2700"/>
    <dbReference type="EnsemblBacteria" id="AFK08299">
        <property type="protein sequence ID" value="AFK08299"/>
        <property type="gene ID" value="Theba_2700"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2700"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="288" mass="32836" checksum="7590D7EA270FB370" modified="2012-07-11" version="1" precursor="true">MRKWLPYLLLVPTFLIIVLFIYYPAVEAFRMSLYRVSTFGNKTTFVGIQNYINLFNNEQYISSVKLTVIYVGLSVTLSIFLGFIIAMLLTQNVPGTKLYRTFLFAPYAISPAIAGTLWTFLLNPVVGHVNYVFMKLFGLQVEWLTSKPYAFYALIFATVWKILPFNMIFYIASIQNVSGDLLEAATLDGAGVMKKTWRIIFPLVSPITFYLVIMNIVSTMFTSFAIVDVMTKGGPGGYTTNMIYRLYLDAFTYQKRGPASAQSVIMFMIMVVVTIVYFTVAERRVHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q6</accession>
    <name>I2F8Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate transport regulator related to PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732002.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2711"/>
    <dbReference type="EnsemblBacteria" id="AFK08309">
        <property type="protein sequence ID" value="AFK08309"/>
        <property type="gene ID" value="Theba_2711"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2711"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104916_1_1_0"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00153">
        <property type="entry name" value="TIGR00153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="213" mass="24673" checksum="3D5752A7F995A761" modified="2012-07-11" version="1">MFFGKKEVAIIQLFHEHLDFISKTLENLEKVFLAIESEDSMSIEIYAEEVRKMESAADAKRREMENSMYQGAFLPNFRGDFLGLAETFDKVANEAENVVDQIILQHLSVPPELRNDLLKQAQLAIKTYEVSKEAALNLFQELSVAEEMIKETERLENVEDSHERALIKRIFEMDLTLAEKRQLRELVLSIGDIANYSEDCSDRMEIIVLKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E0HY73</accession>
    <name>E0HY73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase IS116/IS110/IS902 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0864</name>
        <name evidence="4" type="ORF">Theba_1943</name>
        <name evidence="5" type="ORF">Theba_2435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MesG1.Ag.4.2</strain>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730612.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0864"/>
    <dbReference type="EnsemblBacteria" id="AFK06574">
        <property type="protein sequence ID" value="AFK06574"/>
        <property type="gene ID" value="Theba_0864"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07588">
        <property type="protein sequence ID" value="AFK07588"/>
        <property type="gene ID" value="Theba_1943"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08048">
        <property type="protein sequence ID" value="AFK08048"/>
        <property type="gene ID" value="Theba_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0864"/>
    <dbReference type="KEGG" id="mpg:Theba_1943"/>
    <dbReference type="KEGG" id="mpg:Theba_2435"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674068_0_0_0"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="408" mass="46883" checksum="0F49FE63ECB1A536" modified="2010-11-02" version="1">MEIVGIDWGRKKHYCYLLHQGKKLVLRNKEEDFAKLLKIKEAVYVIEDGNNRIVDYLLRNNRQVYILPSRRSSEARSFFVIEGKSDFIDSKVIAMTYEHNPEWCLQVKREGIAFELDVLVEENAVINVSMMQDIGRLDAYLERYWPEVKEVFSGTSARKLAFISICPTAKDFLSMSDKEILLKLKEMGFLINSNLKSKLKELRKIALERYVPASIRTLIVAFSRYAMEKKVMKEEIGKQMKEIIEKSEFSVLLTLPGVGVIIASQLIVAYLTHKFSSYRDLQRYAGTTPTYYGSGNKNTTKMRSNCNHYLRGTLHIASLAATNSSKWMKRFYDNKKSEGKSSAHALRALANTILKIAFAMLRDLTPYSEEKFFKRNPLSDYTPSKKEGKQKPEYSLKVSSVATCRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E0I262</accession>
    <name>E0I262_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1634</name>
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        <name evidence="3" type="ORF">Theba_1741</name>
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    </gene>
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    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
            <strain evidence="5">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK07368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK08002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07297">
        <property type="protein sequence ID" value="AFK07297"/>
        <property type="gene ID" value="Theba_1634"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK07368"/>
        <property type="gene ID" value="Theba_1711"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07397">
        <property type="protein sequence ID" value="AFK07397"/>
        <property type="gene ID" value="Theba_1741"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK07430"/>
        <property type="gene ID" value="Theba_1778"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08002">
        <property type="protein sequence ID" value="AFK08002"/>
        <property type="gene ID" value="Theba_2382"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08036">
        <property type="protein sequence ID" value="AFK08036"/>
        <property type="gene ID" value="Theba_2420"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1634"/>
    <dbReference type="KEGG" id="mpg:Theba_1711"/>
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    <dbReference type="KEGG" id="mpg:Theba_1778"/>
    <dbReference type="KEGG" id="mpg:Theba_2382"/>
    <dbReference type="KEGG" id="mpg:Theba_2420"/>
    <dbReference type="HOGENOM" id="CLU_3292251_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AFK07297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="40" mass="4394" checksum="3A312DB8AD4D5E53" modified="2010-11-02" version="1">MSPKGVTVSKEVIQVNGKLRRMADEPVVVKNLSERGRDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H9</accession>
    <name>I2F1H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0028"/>
    <dbReference type="EnsemblBacteria" id="AFK05782">
        <property type="protein sequence ID" value="AFK05782"/>
        <property type="gene ID" value="Theba_0028"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
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        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="25258" checksum="DD1A7D1244842B3D" modified="2012-07-11" version="1">MGKKFRDFDPYVLEAFEFDFSSRHARINHGTVLLSWFVEPPKGSRRALELGAGSGVISIYLAKNFGLEVTGVEVDRELHAVATKNASLNGVENLTRFVNCDIDDYAANNRGEVFDMVVSNPPHFLHSGVESPDGKRNRARRIDPELAMVFASATSKLLKNRGAFFFLLHPRDLTKWVRLLEDFKLGIHKMRFAHGSMEGQAQLVLVSGRKSSSSEIVVEPPIRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L2</accession>
    <name>I2F1L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729989.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0064"/>
    <dbReference type="EnsemblBacteria" id="AFK05815">
        <property type="protein sequence ID" value="AFK05815"/>
        <property type="gene ID" value="Theba_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0064"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_2_1_0"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
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        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="318" mass="35153" checksum="509C1CE9994F5E78" modified="2012-07-11" version="1">MAFNRSIIPLLGAPGARLTGTKLKENLTNAKIQFSSLTKLMEEFQPDGIFFMMDLTVEAEALGLEVGFPEDNNPYVKEHPIKGPDELSSVVNSWSGVSGRMRVFTEVADKMARELPGKRGSYVIGPLSLAGELVGVTDLCMKLIEDPAFAESVIDFSSRVVSEYSKALIDHGADMIAVLEPTAVLLSKRQFKRFALPYFERLRSELSKPLIYHICGDTEHIVEPMGASGAYGLSLDSMVDLKAAAERVPENVFIIGNIDPVKVFLQSNEEEVERETEKLLEKMKDVPNFILSSGCDIPLETPPENISAFFRAGRNYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N1</accession>
    <name>I2F1N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0083"/>
    <dbReference type="EnsemblBacteria" id="AFK05834">
        <property type="protein sequence ID" value="AFK05834"/>
        <property type="gene ID" value="Theba_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0083"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="478" mass="55387" checksum="CB946F150A06D100" modified="2012-07-11" version="1" precursor="true">MKSWSLSDKLWLLFAAVLSILFLLLGIVFRWSIRDFFTTEAYRTIEYAQEVRVIELQGGFIPFEDIDLNSLRNARDVGHIIVFDREFDLIDYYLNRFGTQDSSDRTPPLQDSTSRDVLISGTIIPEILPVMKSIKENAEKQTSLSERYETLLSGRSLFYVIRTEEISGRDVTMISYMWDTYMNTLSSTLFSRLLLVMAIMTVVSLVFIIVFSRYLTKPLKKLSEDVRMISKRNWDRPISLNRSDEIGELAGSIENMRKSLSEQDREQQSMLQFISHELKTPVMVIRSYAQAIKDDIYPGGDLDSAIDVIDKEIQRMDLRVKDLLFITRLEYLSRHDLEKEEVNLSELVEDTVGRFSFQRDDIDWNLNLKDFKTEVNEEQLAIAIENILSNQIRYAKNRIEVTMEVDEREENLLMRFANDGEKIPETRLEELFKPFNKGVGGETGLGLSITRRIIELHGGTISMANEEEFVATIVELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q7</accession>
    <name>I2F1Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730026.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0111"/>
    <dbReference type="EnsemblBacteria" id="AFK05860">
        <property type="protein sequence ID" value="AFK05860"/>
        <property type="gene ID" value="Theba_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0111"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_2_1_0"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="405" mass="45100" checksum="241661D292680FCA" modified="2012-07-11" version="1">MREKMNRNISVYYRFKFSQNMLIIGPVLVPYMLFKGLSYSEMMFLQSISAVAVVLFEVPTGSIADRVSRKFSLVISSVITAFGLSLYILCGSFLAFAVAELLFGLGMTFSSGADSAILFESLSRMEREKEYSKIEAKAMSNIFVGQAVGSIASGLLYSVSPYIPFWISLGMLFLSSGYSLFFTEPDHGERSRESYLVHVARSFGDAVKKPRVRWALYFSALMGVMLRASFWLYEPYFKLVRLDIALYGVVFAGFNVVCALSSRYLMKLFENVRPRKSLTFLGLLMGGAYLIPLILLNVGSLAFLALGQIVRALYQPIMRFYINRQIEDAFRATIISIVSLTASLSFAVFSPLIGLGLDRAGAISVYLVMGLVSVGGSLFLWRVRNLQKRKKAAADRKSALDETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q8</accession>
    <name>I2F1Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0112"/>
    <dbReference type="EnsemblBacteria" id="AFK05861">
        <property type="protein sequence ID" value="AFK05861"/>
        <property type="gene ID" value="Theba_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0112"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_3_0"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="316"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="501" mass="54956" checksum="2EA79147FDFA5E02" modified="2012-07-11" version="1" precursor="true">MKKAKFLVLVVLLLSILSFSTTIKMYLVTDYHSHAIPFYSEGQRGFGGIAKIIAFLKDKTGDEDTLVFGGGDMINLGTPAWSDKFHAIEMPWFNNIFDAMAYGNHDSEYGPADFQEVWKDVTYPILGANVLDAGGVPVFEYFGKRYLVLEVEGKKIGVFALAGSDFDSLVKPAARPVEGATFGDFMITASEIVDEMEAEGVDLIVFIGHAEYEETLKLAREIEGIDLIFGTHSHLKIPLTKIEGTETYFISPYQYGTYAAEVVVYFGADGQKSISGSLIPMDDSIPEDPVIADKVEKLQYELESDSEFAHLFEWIGDVETELSAANVNTGESVLGNFVMDIIREKSGANVALSTSSSFRASIAPGSTVYEDLKNALPYVNTIYVYEVKGETLEKILNHSVSQSGTGFFSQVSGVRFIISNGKATSIEVQEDPECPDSFALLNPEATYLVATTNYQGLFAPGYKDLFAGLPCTDTGLDVQKIVKEYMQNNSPVSARLDGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T6</accession>
    <name>I2F1T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730054.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0147"/>
    <dbReference type="EnsemblBacteria" id="AFK05889">
        <property type="protein sequence ID" value="AFK05889"/>
        <property type="gene ID" value="Theba_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0147"/>
    <dbReference type="eggNOG" id="COG0786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034503_1_0_0"/>
    <dbReference type="OrthoDB" id="1284248at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004445">
        <property type="entry name" value="GltS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36178">
        <property type="entry name" value="PTHR36178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="456" mass="50558" checksum="647E4B996DA72C65" modified="2012-07-11" version="1" precursor="true">MEQDWTIVLDIAYLSILMGVASVLKRIITPLSKILIPNAVIAGFLGILFGPEVLKVIPFSYDRLGNLVYHLMAIGFIAIALKKTRRSSTKSSVNTGFLISMSYALQGMVGFVVGIALVGLFFKDLFPPFGLLLALGFAQGPGQAYSLGSQWEALGFTGGGAVGLSVSTLGFLWAAFGGIVMLNAMVYRKRQIGIQIEKPTLKKRIEATIRDFEFSDIDGFTIQILAVGIVYLVTYLFLKWFTGLIGGLGTFGETFAQVLWGFHFVIGVLFAMAFRAIYEKVRKSEKYEIEYMNDFLLQRIGGGVFDFMVAASIAGISFTVIQEYIWPIIILTTIGGFFTAGYTIWFGKRIYEKAPLEHIVTFFGMHTGTLSTGMALLREVDPTFESGTAEDMVFGSGLALFLGIPMLILLNIPILGYRMEQPIYYLYFILGLAAYIGAMYFFWFRKAKIRGKEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U9</accession>
    <name>I2F1U9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Homoserine kinase</fullName>
            <shortName evidence="10">HK</shortName>
            <shortName evidence="10">HSK</shortName>
            <ecNumber evidence="4 10">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrB</name>
        <name evidence="12" type="ORF">Theba_0161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490371.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0161"/>
    <dbReference type="EnsemblBacteria" id="AFK05902">
        <property type="protein sequence ID" value="AFK05902"/>
        <property type="gene ID" value="Theba_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0161"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_2_0"/>
    <dbReference type="OrthoDB" id="610857at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="79"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK05902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="30922" checksum="4A96C8134902CAEE" modified="2012-07-11" version="1">MRLKAPATTANMGSGFDVVGMALKLHNTVQFEKANRFKVHSIGRYGLEIGDAAETFGNAIERFEKLTGKKVPALQIIQECEIPPARGLGSSAAAIASALFISNIMTGGRIPTDALLEIGTEIEGHPDNIVPCMVGGLTVSYYDGSRLDYEKFEMPDHRLTFLVPEFKLSTEAMRKALPDSIPFKDALGNIKNVSQFISKASRGDFAGALKYTKDFIHQSYRIDSDPRMKELVDRTEERNPGYWFVSGSGSSICCDLEDTGGLPYLEAVIRTSPANEPFIVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y4</accession>
    <name>I2F1Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine dehydratase</fullName>
            <ecNumber evidence="8">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730100.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0202"/>
    <dbReference type="EnsemblBacteria" id="AFK05937">
        <property type="protein sequence ID" value="AFK05937"/>
        <property type="gene ID" value="Theba_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0202"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086592_0_0_0"/>
    <dbReference type="OrthoDB" id="1720141at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="222" mass="23932" checksum="E69D5EC1C73F0B62" modified="2012-07-11" version="1">MLLDIIGPAIVGPSSSHTAGMARLGRAFRSLFAKTPNEVRFVLNSPLFATFRGHGSDRALVGGIMGIKESDPMLRDSFQIAKGKGIYFTFEEEDMGDFHPNTVKINGSSGESFLTVTGASVGGGSVRITAIDDFETDVTGKYPSLVILNADIPGALSKIVGAISSSDMNISNLFLSRVDPFRHEALCVVELDNEPDEHLLSAIKRLEVVKKVSYLERLDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F236</accession>
    <name>I2F236_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730148.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0255"/>
    <dbReference type="EnsemblBacteria" id="AFK05989">
        <property type="protein sequence ID" value="AFK05989"/>
        <property type="gene ID" value="Theba_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0255"/>
    <dbReference type="eggNOG" id="COG0549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_0"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="33871" checksum="79F4A1CB677D51D4" modified="2012-07-11" version="1">MKRIVVAIGGNALNKPNEKPTAEVMEKNLLSTTAYLADLVEEGYELVITHGNGPQVGNLLVQQDIAKDVFPPFPIDVNDAMTQGSIGYLITQTLNNELVKRNTRKNIACVLTQIVVDKNDKGFENPSKPVGPFYDSETAKELERTKGWTVKEDAGRGYRRVVPSPMPLDVLEIEPIREMIKDGTIVVAAGGGGIPVVRDESGQIKGVEAVIDKDRASALLAKLIEADALVILTGVDYAYINFGKDNQRELKELTVKEGRELMEAGHFAKGSMLPKIESAIEFVSLTGKEAIITSLENVDLALKGESGTRIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F247</accession>
    <name>I2F247_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730158.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0267"/>
    <dbReference type="EnsemblBacteria" id="AFK06000">
        <property type="protein sequence ID" value="AFK06000"/>
        <property type="gene ID" value="Theba_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0267"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_3_0"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="84"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="27682" checksum="B3F09C62983C9B0D" modified="2012-07-11" version="1" precursor="true">MRFLKKLLSLLVTVWIAVLGVLYICVYGGIVILIGNVIGKFKGKKERKTFISREVSRFGRAAFVLSGSRVRLSGKENVPETGPMVIVANHQSAFDIPLIPGYVYPEIAFIAKKELSKIPGISWFISALDGVYIERGNRLQTAGAMRKIFRILKEDGTILLFPEGTRSEAGEIGKFKEGSLSIPYKLGVKVLPVALDGTRNLLRKNSFLITPSRISLSICKPILPQDFSSEEDFSGEVYNIIKAALESMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F293</accession>
    <name>I2F293_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491783.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0316"/>
    <dbReference type="EnsemblBacteria" id="AFK06046">
        <property type="protein sequence ID" value="AFK06046"/>
        <property type="gene ID" value="Theba_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0316"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_6_2_0"/>
    <dbReference type="OrthoDB" id="2034545at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="83" mass="8517" checksum="67BD48CE04E02C58" modified="2012-07-11" version="1" precursor="true">MVVLAYVLISLHIAISVGLGIAVMMQMSKSAELGGAFGGGASHTMFGRKKGLDTMGKITLGLAIGFMVNSILIAFVISRAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H4</accession>
    <name>I2F2H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730246.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0399"/>
    <dbReference type="EnsemblBacteria" id="AFK06127">
        <property type="protein sequence ID" value="AFK06127"/>
        <property type="gene ID" value="Theba_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0399"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="139"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="448" mass="50282" checksum="F838722EB28CC016" modified="2012-07-11" version="1">MKRKVLVVDDDLAFNGLLGAALEEEGYEVVQVYNLEQTLKQISEEVFDCLILDVRLPDGSGLDIISEAALSSPVIVVSAHGDINTAIDAVKKGAFNFLEKPFDLNHALLEVKRAIEFSEVSRERDSLADLVTTEPSVEIIGKSKNILELKQMIAAIAPKKVTVLLEGESGTGKEVVARSIHQKSGRGKFVPINCGAIPENLFESELFGYEKGSFTGAMNSKPGLIEESHRGTLFLDEISEMPLPMQVKLLRVLETSSSQRLGGTTSRKLDLRVIAATNRDLEVEVSKGNFRSDLYYRLNVVKIKIDPLREKREDIPILIHHFLPRLCEELGMKKPPTIPEDFMNKMKAYDWPGNIRELRNRLLSILAVNGSFEGVSSFAFPEVEQADDQDFRFREVSLDELERRYISWLIDRQNGNKTKAASILQISKSTLYEKLKRWSNLEGNNDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I1</accession>
    <name>I2F2I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492003.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0406"/>
    <dbReference type="EnsemblBacteria" id="AFK06134">
        <property type="protein sequence ID" value="AFK06134"/>
        <property type="gene ID" value="Theba_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0406"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="35598" checksum="706F8CCEE31C893C" modified="2012-07-11" version="1" precursor="true">MGVFHIKRKTKRGIISFLILSPTFAAIGVFVYFFIGWTGRTSVSNWNSFARLLKGEFEFVGLRNYFRLFEDPRFQTDLWNTLYFTLFFILGCLLLGIVLAVLIDRNLKGSGIFRNIYLFPMALSFVVTGAVWRWIFAPGILPSNPQGMNLLFSLVGLDFLQWRWFTSTESFLNFNFALIPVIIAAVWQMSGYTMAMYLAGLRGISQDLVEAAEVDGATGWQIFWKIKFPILRPITLSAMIILGHISLKIFDLVYAMTGSGPNNVTDVPAIYMFETTFRANKYATGSAIAIIMLLMVAVVIIPYLASAFRKEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P5</accession>
    <name>I2F2P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type proline/glycine betaine transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730311.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0472"/>
    <dbReference type="EnsemblBacteria" id="AFK06198">
        <property type="protein sequence ID" value="AFK06198"/>
        <property type="gene ID" value="Theba_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0472"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_2_0"/>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="23507" checksum="016136490B4A5DFF" modified="2012-07-11" version="1">MGFFEYLGRNYDLVLIELLNHIKIIAIAIPIAIGIGVPIGIVVSRSKRASSIALYGAGILMTIPSLALFGYMVVLLAPLKAGIGVTPAVIALVIYSFLPVIRNTVVAVNSVDPRMIEAARGMGMTNWQILFRVRLPLTIPIIMAGVRNAAVMGVSVATIAYLIGARGLGYFIFSGLGRSNFNMVLLGALIVSILGIGTNYGLLALEEIITPRGLKIEREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T7</accession>
    <name>I2F2T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-dehydroquinate synthetase</fullName>
            <ecNumber evidence="4">4.2.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730347.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0517"/>
    <dbReference type="EnsemblBacteria" id="AFK06240">
        <property type="protein sequence ID" value="AFK06240"/>
        <property type="gene ID" value="Theba_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0517"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052952_0_0_0"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="29327" checksum="FAECBFAA98B91F07" modified="2012-07-11" version="1">MKRITFTSESTERCQLIFGKNMIEKLPESIRVVDSGFKKSFAGNLKSEYLMPGGEHIKSIDRVFEIYQLVRVSRCKAVTAIGGGSIIDLVGYACAGHTEVEKLFLFPTTTVGQIMPAINGFKLNFEFVKDLLCANGIPDRVFIDSSISYKEYLDSSRSDLLFPLLVALSFDMRLFKYISNLVASGKEITEEQWDDIVFSSVKAYLKGIELKKPFVGAETAGLIETASRLRAGNRAAVILGAMVELRLAREFSNNDVKSSEVFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U6</accession>
    <name>I2F2U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730356.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0526"/>
    <dbReference type="EnsemblBacteria" id="AFK06249">
        <property type="protein sequence ID" value="AFK06249"/>
        <property type="gene ID" value="Theba_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0526"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707472_0_0_0"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="390" mass="44516" checksum="59CB272E71BF248B" modified="2012-07-11" version="1" precursor="true">MKSAFAVAIFLVSVSLIFALDNAELLLSKEYLIELQSLETQSVETKAILAIAVGLKYRETIQPNYKVWFSNLYEELKDKALPSEIEEGIKIVNELVSVSTVSALNMLYSTQNSDNLIKAISLRAFFYDWVDTRDPRSSEEIVKTAYELIELLPNQYFPYKALLEVYSSGSSIDKDRLMEIRERIFSEGLQDLLGDDLIESEFVSGLEELVLEDYSRLGTGEPVSMYYAAMAYMKMGESFDALEILNSIDLHRIPPRFASNASMVVGNYYLGNGDFEEAVKNYQDSLRFWPENSMAVRNLGMAYYLTKDRDYYDLARFYLQLSGYESFDDEVSSALKELRRRAIFELALVTIVPLAAIVVVGLFLLEYFSKKRKTSQERKAMKEDGGNNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W5</accession>
    <name>I2F2W5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492174.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0545"/>
    <dbReference type="EnsemblBacteria" id="AFK06268">
        <property type="protein sequence ID" value="AFK06268"/>
        <property type="gene ID" value="Theba_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0545"/>
    <dbReference type="eggNOG" id="COG1656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112469_0_0_0"/>
    <dbReference type="OrthoDB" id="1864081at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="158" mass="18289" checksum="2E5E88CE5E41EF99" modified="2012-07-11" version="1">MRFLVEEPLTKLARKLRLMGFDTEICSRNEIGKSFENRDVFLTKSKKAMEIAIKFGIRSYLIKSENWRSQLKSVIQRFQIGLDDVHFLSRCSKCNGLLEEASLKDVAMVPDYVVLTAERLYKCTRCGQLYWNGSHVQHMKWMNEIAGKSGGNAEENKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z8</accession>
    <name>I2F2Z8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp</name>
        <name evidence="12" type="ORF">Theba_0582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730390.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0582"/>
    <dbReference type="EnsemblBacteria" id="AFK06301">
        <property type="protein sequence ID" value="AFK06301"/>
        <property type="gene ID" value="Theba_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0582"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_0"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="340" mass="36920" checksum="51849609663349C7" modified="2012-07-11" version="1">MRIGILTGGGDCPGLNAVIRGIVKSAPENVEIIGLMHGWKGLVVGESMKLTDNDVEGIHILGGTILGTSRTNPFKSEDMRIKMEENIKKLGLDVIIGIGGDDTLTVAARLSSMGYKAIGVPKTIDNDVANTDYTFGYQTAVNVGADAIDRLHSTAKSHGRIIIVELMGREAGWVTLEAGMAAGAHLILIPEYPMTIDEILTYVKKRMDRFGYMIIAVAEGFKPTELENVVGDESKIDAFGHIKLGGIAHYMANIISERTGYDTRSVVLGHLLRGGTPTAFDRILGTRYGVHAMELVMKGDFGRMVALKGNDIISIPLEYGIATKKLVPFEYYKLSQIFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F312</accession>
    <name>I2F312_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730400.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0596"/>
    <dbReference type="EnsemblBacteria" id="AFK06315">
        <property type="protein sequence ID" value="AFK06315"/>
        <property type="gene ID" value="Theba_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0596"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657744" description="Dipeptidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="572" mass="64633" checksum="F132C7410088D1F4" modified="2012-07-11" version="1" precursor="true">MKVLGKCFLVLLLVSVSSSMACTTLIVTKGASADGSMIVAHSDDNDLADQRIVYVPAQDHEPGSFRPVYCSAVAMGEFHQYNSFIYPRIVSDRAPAYDTPGYPLSIPIGMIPQVDHTFAYFDGSYGIMNEHQLMFGECTDGAKIQIGPEPGKRIFYSSELSRVALERCKTAREAVELIGYLIEKYGYYGTGETLPVADPNEAWVIEMAPSPEGTGGLWVARRVPDGEVFVAANQFRIREIDTENPDFLYGETLHEVAEKFGWWDPKDGPLDWLRTVSLGEYNHPYYSLRRVWRLFSSMAPSMNLSPWVEDGFTREYPFSLKPDNKVSASDVMNLYRDHYEGTEFDLTKGVAAGPFGYPDRYYGPYDGQGDVGDPSRQLGGAWERPISVTYCGYAFVCQARNWLPDPVGGIMWLGLDKPADTCFIPFFVGVSDLPESIQVCDTSEFNKDSAWWAFNFVSNWAALKYSYMHEDIKLMQEKYEALSLSRLPEIEAHITKILLTKPEEAGRYLARFCSRNSQEIVEAWWKLSEYLIVRYNDGFINEKGNMAQPTGYPKEWLDETGWADGPTSYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F332</accession>
    <name>I2F332_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0597 protein Theba_0617</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0597 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730413.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06335">
        <property type="protein sequence ID" value="AFK06335"/>
        <property type="gene ID" value="Theba_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0617"/>
    <dbReference type="eggNOG" id="COG3681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051840_0_0_0"/>
    <dbReference type="OrthoDB" id="1326279at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01845">
        <property type="entry name" value="UPF0597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006054">
        <property type="entry name" value="UCP006054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="167"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="418" mass="44985" checksum="1CF00A93508C2A3E" modified="2012-07-11" version="1" precursor="true">MRFLEQYLEREVRPALGCTEPGAIAFCVALAASKLEGKTEKVHVTTSVNVYKNGMYVGIPGTNEKGNEFAGALGAICGDPDLQLEALRPCRIESVDLAREMIDKGLVSVVCDQDLSGVFIEATVSNHNHSVLCRIIGSHTNVVSLEIDGEKVRSSERFVPSDELDFTPEEIFESIREITELEIEKIFEGIEMNLEIARFGLKKMLPSKETFSYHENVSLGYKIRNYCFAASAARMSGVPLPVMSSSGSGNQGIVATLPVALTGEYFQKSRKDIAKAVALSHLFSGYIKNKLGRVAPICGCVTAAGTGAAAGITYLLGGARETIEQAMLTILSSTTGIMCDGAKESCSLKAGLGGQEAYSCALLAMDNLGVNSEQGFISNTLDRSIENIQVLLSKGMSKIDSAIVEVLENRKRKTKSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F381</accession>
    <name>I2F381_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ORF">Theba_0667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730458.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0667"/>
    <dbReference type="EnsemblBacteria" id="AFK06384">
        <property type="protein sequence ID" value="AFK06384"/>
        <property type="gene ID" value="Theba_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0667"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_0"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="370" mass="42582" checksum="15FC59E77640BD36" modified="2012-07-11" version="1">MISYETNSRIQELKEKFDSIRATLDLERIDEKLKEIEKRMSDPSIWNDQREASNLGREAQSYRSTIELLRDVEEEFESIEIAVELSGEDESYVKHVEELVRSAEKKVREFELTILLSGEYDINNCFISIHPGAGGTESQDWASMLMRMYMRWAEANRFKITIVDELPGEEAGIKSVTINLAGPHAYGKMKFEAGVHRLVRISPFDANHRRHTSFASVSVFPEMDEVPEIEIRPEDLKIDTYRSGGAGGQHVNKTDSAVRITHLPTGIVVACQTERSQHQNKANAMKMLYAKLFEIEIEKKRSEKLKLMGDQKEISWGNQIRSYVFQPYTLVKDHRTDFETGDIQSVMNGEIDEFIEKELLFFSSIEKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A3</accession>
    <name>I2F3A3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">Theba_0689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730469.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0689"/>
    <dbReference type="EnsemblBacteria" id="AFK06406">
        <property type="protein sequence ID" value="AFK06406"/>
        <property type="gene ID" value="Theba_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0689"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_0"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="186" mass="21121" checksum="5F24153F7F73DDC5" modified="2012-07-11" version="1">MAYEYVPLKDRYENEVIPVMTKEFGYKNKLEVPRVSKIVVNMGIGEGSRNADLLDLHGKELMTIVGQKPVVTKAKRSIANFKLRDGMPVGLKVTLRGPRMYNFLYKLINIVLPKLRDFRGVDPDSFDGRGNYAMGLPEQLVFPEIVPDQIKRVQGMDIIVVTTARTDEEARRLLALLGLPFKRVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D8</accession>
    <name>I2F3D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpS</name>
        <name evidence="10" type="ORF">Theba_0724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730499.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0724"/>
    <dbReference type="EnsemblBacteria" id="AFK06441">
        <property type="protein sequence ID" value="AFK06441"/>
        <property type="gene ID" value="Theba_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0724"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_1_2_0"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="13802" checksum="84E7002F1F46BFF6" modified="2012-07-11" version="1">MNLNIRTGIDIVEISRMTESIAQRILGKDEKVIYDSLGGERRRMEFAAGRFAAKEAFVKALGRKDIEFSKIQFLTDEGGRPIPSDELKQLIKNSDLTVSISHEREYAVSIVILFGRDQNDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E6</accession>
    <name>I2F3E6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ORF">Theba_0734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492410.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0734"/>
    <dbReference type="EnsemblBacteria" id="AFK06449">
        <property type="protein sequence ID" value="AFK06449"/>
        <property type="gene ID" value="Theba_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0734"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_8_0_0"/>
    <dbReference type="OrthoDB" id="1974284at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="68" mass="7397" checksum="015D1B0D57D200B9" modified="2012-07-11" version="1" precursor="true">MAKAKFWKFLSEVKNEVKKVTWPNREQMISSTGAVLVILIAVGAFLALLDVLFTNAIGSLLNFLTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G9</accession>
    <name>I2F3G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate-formate lyase-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0757"/>
    <dbReference type="EnsemblBacteria" id="AFK06472">
        <property type="protein sequence ID" value="AFK06472"/>
        <property type="gene ID" value="Theba_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0757"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078147_2_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="23738" checksum="C04BB32E799FFD8F" modified="2012-07-11" version="1">MDYPGKVALTLFTSSCNFDCAYCHNSELKKRVKEELGESEVFDYLDKRGKLLDAVVITGGEPTLRASELLPFMRRLKSRFPETLLKIDTNGWNADILQEFLKIVDYVAIDLKSLHYEIFSPVNLREIEDSIEIAKGFANHEIRITMFPPYLPEDDFEELSKICGGASLVSVQQYKPVAGLCETPPYPSSVLKRFADLISDHAQKVIIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I6</accession>
    <name>I2F3I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730543.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0775"/>
    <dbReference type="EnsemblBacteria" id="AFK06489">
        <property type="protein sequence ID" value="AFK06489"/>
        <property type="gene ID" value="Theba_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0775"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_3_0_0"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="28340" checksum="8B996DF2D7E679A0" modified="2012-07-11" version="1">MSVDLHNHSSFSPDSQTPVEEIVEEAILKGLKVIGISDHDDLDDSFPDSYRMKDPEIYLRSLSRMKENSVIKVLAGLEVGLQSCAKTLPEGDFDYFIYSVHGIPGIKDLTSGDVWTLYLEEAIEAISGIDRPGFFGHIDFLRRYLPGHKALDNEELLCELLRKLIRAGIGIEINTSGWRYPYKEPSPQRWIVEKYFLCGGKFVTIGSDSHRREDVGSHVSDALLLLKSIGFKEVFYCEKMEYKPVALTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q1</accession>
    <name>I2F3Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730595.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0840"/>
    <dbReference type="EnsemblBacteria" id="AFK06554">
        <property type="protein sequence ID" value="AFK06554"/>
        <property type="gene ID" value="Theba_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0840"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_2_0_0"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="52"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="278" mass="30734" checksum="FAE08E3D1C8CE0B5" modified="2012-07-11" version="1">MAIARLTKYLRQDRMPHVWCPGCGNGVIMKAFIDAVDKNALDPDRVSVVSGIGCSSRVTGYLNFNTMHTLHGRAIAFATGVKLARPEFKVVVMGGDGDILAIGGNHFIHACRRNMDITVIIFNNNIYGMTGGQYSPTTPHEKIASTSPYGNVENSFDIVNLALASGATYVARSTVFHYAQMVQLIQKALDHKGMAVIEIMTNCHTYYGRYNAMSQPEDMLAYFKKNTVQINKARTMSPEELADKIVAGEFVNKNADTYSDSYRKKIEELMKAERGDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R9</accession>
    <name>I2F3R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0862"/>
    <dbReference type="EnsemblBacteria" id="AFK06572">
        <property type="protein sequence ID" value="AFK06572"/>
        <property type="gene ID" value="Theba_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0862"/>
    <dbReference type="HOGENOM" id="CLU_2666861_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="75" mass="8054" checksum="2B6A9F0C9174048E" modified="2012-07-11" version="1">MDARLASSGSDAPKNIGGSDARKVIRGSDARLREEERNIRLNTPKSIGGRTPTKNMSGRNALRSISGRKADFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X7</accession>
    <name>I2F3X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730653.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0924"/>
    <dbReference type="EnsemblBacteria" id="AFK06630">
        <property type="protein sequence ID" value="AFK06630"/>
        <property type="gene ID" value="Theba_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0924"/>
    <dbReference type="eggNOG" id="ENOG5033775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639050_0_0_0"/>
    <dbReference type="OrthoDB" id="1099240at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="437" mass="50623" checksum="F384442505C31E72" modified="2012-07-11" version="1" precursor="true">MADHHLKFALSARTRRAAVVFLFVFVLSYVFTSVSVWTTDSRFITVSRFIRVYGHENLIRGTGYAPEQYRFGGFYLVENFFKYIPLKWYDVYNTTLSDLLISEETWTEEMQKTVDKFFPQDDREEMIGEVQRVIDKTLESFFPGNALVQNLLRGMIDGLHWQGYLTNIEETLLTLGEMIPENIRNHLLEDSEETRLVNGYFTSRFFLFMILLTIIYFLCREFLNTVQSLFGVVLFAALVPIALQDFLQAETVLSLVLFSSMLLLTKRDGSRLVLLLVTILCCTARTDHALFGALIYGLMHGIESLRRRQWFGALFSALLLIIPVAATALISVFLFPEAEYYVDLIQLEFNITHLWSWIFPSILLLLPIVFFSQIKHVEFYRKTWPWIPFFVAANFIVGKTAEVRLFLPLVIYSIPLVIGGMKRSLEGEEDLTDSREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F417</accession>
    <name>I2F417_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730691.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0964"/>
    <dbReference type="EnsemblBacteria" id="AFK06670">
        <property type="protein sequence ID" value="AFK06670"/>
        <property type="gene ID" value="Theba_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0964"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_0"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="201" mass="23635" checksum="B9E0A9B7AEE7E3A3" modified="2012-07-11" version="1" precursor="true">MGRIIVLAGNVGAGKSTIASAIAEGLGFNIHYESVSDNPFLEDFYYDQKRWSYHLQTYFLYHRYCSLKSAEVNENTVFDRSIYEDKEIFARNLFETGKMSDREFKAYVTMFDSMIKYLKKPDLLVYIDADVDTILARIRRRGRQMETAVPIAYWEQLDRLYSSWIRDYDLSPIYKIDARSVDIVINPEKAQQITKEIMRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F430</accession>
    <name>I2F430_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase of aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730699.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0977"/>
    <dbReference type="EnsemblBacteria" id="AFK06683">
        <property type="protein sequence ID" value="AFK06683"/>
        <property type="gene ID" value="Theba_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0977"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_2_0"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="42876" checksum="448AFBC1BFF8E194" modified="2012-07-11" version="1">MIRREMGKTGEKVSALGFGCMRLPTRDDQSIDVDEATRMLRFAIDNGVDYVDTAWGYHNGQSEPFVGSALQDGYRDKVNLATKLPSWLIKCREDMDYYLNEQLRRLRTDVIDFYLIHALNRRYWKNLKEHDIFEFMDSALASGRIRHIGFSFHDTLDVFKEIIDSYGWEFCQIQYNFVDTEHQAGLEGLKYAADKGIGVAVMEPLRGGKLATNVRDDILSIWTSSGIDRTPAAWALRWVWNDPDVGVVLSGMSTMDQVRENIETAREASPNSMSSSELAIVDRVREEYKKRIKVSCTGCSYCMPCPSGVAIPTCFDFFNDAYMFDSIEDHKKAYLRSVKKENRASLCVECGRCEELCPQNIPIIEQLKEVSSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F434</accession>
    <name>I2F434_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">Theba_0981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730702.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0981"/>
    <dbReference type="EnsemblBacteria" id="AFK06687">
        <property type="protein sequence ID" value="AFK06687"/>
        <property type="gene ID" value="Theba_0981"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0981"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_0"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="189" mass="21036" checksum="956DE4924D4E8FBA" modified="2012-07-11" version="1">MFLFVGLGNPGPRYALTRHNVGFLFIDQMAKLGLRKTVQKRLYEAHLLEGEEKVYIAKPLTFMNLSGVAVRLLMKDLNFEKKDTLVLVYDDVWIPLGRMRIRESGSDGGHNGLKSVISEIGTQSFPRIRIGVGPLPENGDMVDYVLGKFSDDEYQKVSKVIGLAVSAAKELISGDIRKVMTAYNGTEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F436</accession>
    <name>I2F436_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ORF">Theba_0983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730704.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0983"/>
    <dbReference type="EnsemblBacteria" id="AFK06689">
        <property type="protein sequence ID" value="AFK06689"/>
        <property type="gene ID" value="Theba_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0983"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_0_0_0"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="21957" checksum="DC1AF8CEBD32B161" modified="2012-07-11" version="1">MLEGIEGRVREIRETEIVIQVGGLFFKVNCTPNTISKLPVEKDVYLLTFMAYSQDRPPELYGFYDQEEKELFNILLRASKIGPKSAMKILSSASPSRIKHIISTKNAAELSSLPGIGKKTAERMIVELASLVDTSGITDEETIPGVERSHGEEAVAALTSLGFDENQSRKVVIEILKAEREIDTHDLIKKALKEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F443</accession>
    <name>I2F443_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730711.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0990"/>
    <dbReference type="EnsemblBacteria" id="AFK06696">
        <property type="protein sequence ID" value="AFK06696"/>
        <property type="gene ID" value="Theba_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0990"/>
    <dbReference type="HOGENOM" id="CLU_2899015_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="62" mass="7586" checksum="0FADBAC01B32EEC5" modified="2012-07-11" version="1">MEVKKPKWFDSWIEIDESYLKVAGTSWRLKANAPKKVKREYQRLLKQITGNNDYPYSWKHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F468</accession>
    <name>I2F468_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730731.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1016"/>
    <dbReference type="EnsemblBacteria" id="AFK06721">
        <property type="protein sequence ID" value="AFK06721"/>
        <property type="gene ID" value="Theba_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1016"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_0_0"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="40871" checksum="C974444E7B9B28D2" modified="2012-07-11" version="1" precursor="true">MRVKIEKRLVIPKYSSILVPILSVVAALVLMGIILMVFFYGRLGSFSLAFRETFDAYKEMLTWPFANKYGIFSTLMRMVPLAFVGLGLSFAYRMKIWNIGGEGQLYMGALAATWGALFLFKDVSSPLAMILLLSITGAVAGGLWALIPALMKAFAKTDEIVVTLMLNYVAIFWVDYLVYGPWKDPKGYGFPGTAPFPDQARLPTLFKGEFHVGFFIAVAIAVVLFYVYRKTSWGMNSKIVGDNAQAARYSGISIVRYTIIALVVSGAIAGLGGAVQMMGVQHRLQHGFSPGYGYTAIIVAWLAKLNPIAILLVSFLFGGLLVGNDQLQMFYKLPMALISVFQGLVLFSLLGGETISRYRLRIVKEEAAHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F496</accession>
    <name>I2F496_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ORF">Theba_1044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730755.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1044"/>
    <dbReference type="EnsemblBacteria" id="AFK06749">
        <property type="protein sequence ID" value="AFK06749"/>
        <property type="gene ID" value="Theba_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1044"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_7_1_0"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="207" mass="22413" checksum="45075F235A42757B" modified="2012-07-11" version="1" precursor="true">MRYLLFALVGYVMGSIPFSFIVPLVKGVNITKVGSGNVGGTNVLRSMGGYAGAVAMILDGVKAFLPVLIARAVFGVSLPEGMMIGFFAAVGHSYSIFLKFRGGKAVACTVGTLSGTLPWYVAVFFGIWIPIVLVTQYVSLGSLLALAILSGILFLTEGYAVGLWMLAFFGLSLFRHRKNVLALFRGEERKTDLIAAFKRKRNEMKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E0</accession>
    <name>I2F4E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730791.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1088"/>
    <dbReference type="EnsemblBacteria" id="AFK06793">
        <property type="protein sequence ID" value="AFK06793"/>
        <property type="gene ID" value="Theba_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1088"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="35153" checksum="8966782C17750113" modified="2012-07-11" version="1" precursor="true">MRKFIVRRLLQIVPTLFFVLLTVFFLMKLIPGDPAAVLLGPGARAQDIERFRAELGLDQPVFTQFALYLKRVFTGNFGKSLIYKQDVISLIVERLPTTLLLSVSALFIASIIGIPAGILAATKHDSFVDFSITILSLVGISVPIFWFGMILIIVFALQLGWLPAVGIGNISNGLWDVVKHIILPSTALGIQSMGIITRFTRSSMLEVLRQDYVRTAMAKGLKNRLVLYNHALRNALVPIVTVIGLQLGTLLAGAVLTETVFALPGLGKLMIDAILRRDFLLVQGEVLVIAFIYILVNFIVDMLYAFLNPKIRVAYGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L2</accession>
    <name>I2F4L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730854.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1167"/>
    <dbReference type="EnsemblBacteria" id="AFK06865">
        <property type="protein sequence ID" value="AFK06865"/>
        <property type="gene ID" value="Theba_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1167"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_7_0"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="135"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="503" mass="52272" checksum="F4BD402506B65449" modified="2012-07-11" version="1" precursor="true">MKRNIAVSIGLIVLVIAFMVSGCVKSIDVPRSPAIDWSVQAVDGQARVIIGFSGLPDKGLVKAFGGEVFAEFGFIKALSAKIPVEAIDGLLRNPHVVYVEPNIELHALEEQYLWGMNRIFGEESFEFPTWETSTGAGVKVAILDTGIDPSHPDLAGRVSEGVDFTGIGSSFDDNGHGTHVSGTVAAIYSNNDGVYGVAPDATLVPVKVLSASGSGTLESIIWGIQWAIDNDIDVINMSLGTSSDMQSLEDACNAAFADGILIVAAAGNSGNKPGNRDTVEYPGGYASVIAVAASDSNDARATFSSTGPDVELIAPGVSILSTIPGGDHAYYSGTSMASPHVAGVAALVLAAKPTLTNAEVRLILQQTAENLGLKQEHQGYGLVRADLAVQAASVTTPPASDTDPEPGTVTVSNISYSLSRNAKHMYVSVQLDPVVVGASVSIEVYLNNGSSPYFVGTITTDTSGVTKFTVVNAPSGSYSTVVTDVSAAGYTWDGVFPENSYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P9</accession>
    <name>I2F4P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730889.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1205"/>
    <dbReference type="EnsemblBacteria" id="AFK06902">
        <property type="protein sequence ID" value="AFK06902"/>
        <property type="gene ID" value="Theba_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1205"/>
    <dbReference type="HOGENOM" id="CLU_773405_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658318" evidence="2">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="40116" checksum="B8655A99634F4126" modified="2012-07-11" version="1" precursor="true">MRRNHFYFFFLMLFIFISISSLAGNNDSTDSADATVTTYFEDVAREILAMDSFDDLFSLDGFFEDDPAAELTPSQPIPPTPVSTVSHEDPAMPSITPQATQSETESPESTLTWKYEPYADSLLPGGIAFEFEAGDPVMGIPDVVKFYKEGVVVDTLAGKTIMSPVIVSDVPFPGQKTTIFRFLTDDYSTPLGGYYITVVDSEVYSLTVALDPTRAENIVDLDCDGIVELIVVDDHMIKAQEETELSVFKRFFTWTEDGWQVDSPGDYVNVYSSMAEADLEKIEASSPKTPHVWSYAYHSYMAGEDLEEIQFRVAKLVEDFSLNWLINSTEMVKLLDQNINQYDGYVMKRPTPDSSPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S7</accession>
    <name>I2F4S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730911.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1242"/>
    <dbReference type="EnsemblBacteria" id="AFK06930">
        <property type="protein sequence ID" value="AFK06930"/>
        <property type="gene ID" value="Theba_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1242"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_9_0_0"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="16853" checksum="34DFBF900289CDDD" modified="2012-07-11" version="1">MKVKEAMIRDVSAIFEDETIEDFIVFCLRQNKSGLPVVDEEFKVVGFLSESDVIKSALPSYFSLLQSASFIPDTHQFVIRLGKIKDDHVSQHMVKPPVLIKPDDTVIYAADLLIKNGLKIMPVVDDEGKLVGIVNRIYLIHVATQGKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S8</accession>
    <name>I2F4S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MiaB-like tRNA modifying enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730912.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1243"/>
    <dbReference type="EnsemblBacteria" id="AFK06931">
        <property type="protein sequence ID" value="AFK06931"/>
        <property type="gene ID" value="Theba_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1243"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_0"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="129"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="425" mass="48273" checksum="67F653F367723E02" modified="2012-07-11" version="1">MKQKVSIYTFGCKMNQYESQAMAEMLHDYEVGFSQDKADLFIVNSCTVTSEAERKLRQLFRRLKGLNPNSKIIITGCYSQLSPNELRELGADEVIGVREKKAIHKYVSRQLNRPDGVAPSEFLTVTSSIEGRTRAFLGIEDGCLNCCSYCRVRLARGSKIISKPIDLVKREFEGLVSRGYREIVLTGINIGYYGFDLDSSLVKLLIELDKLEGEWRIRLGSLDPDRVDGELLHLITTSRRMARHLHLSLQSGSNRILRAMRRKYTVDEYLRAVDRARSVDTRFAFTTDLIAGFPGENDSDHKESLKVVEQVEFLKVHVFRFSRRPGTEAAEMKDQIDSGTKKARSHELIEAGKRSRKKYLERQIGRKACVLIQKTGHTESSGFDEFYAPHAIEGAHEGFVNATIISIESQREGSDAELYCRSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T2</accession>
    <name>I2F4T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730916.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1247"/>
    <dbReference type="EnsemblBacteria" id="AFK06935">
        <property type="protein sequence ID" value="AFK06935"/>
        <property type="gene ID" value="Theba_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1247"/>
    <dbReference type="eggNOG" id="ENOG5033YGT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298555_0_0_0"/>
    <dbReference type="OrthoDB" id="1941153at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032607">
        <property type="entry name" value="DUF4894"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16235">
        <property type="entry name" value="DUF4894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="212" mass="24309" checksum="D8B9852B44486CAE" modified="2012-07-11" version="1" precursor="true">MSLSLRAGICMVILFAMWILSIVNFVLESFFTEPVEQLTRIVNKDEILIEFPLAFRRAWKTDIIYPPGSVDVSGGRVYLKPGKYIVSYEGKYYWVSEDFVIVDYAHLSEILSYPIMGGIQFILTDGVYVASERDIDIFAGAVEGILADRRVLALVSYFDFENNVLLLRRGIRVKVLDWESLETNKELLLQLENASDRSEYIFLSDGKLLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U0</accession>
    <name>I2F4U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730924.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1255"/>
    <dbReference type="EnsemblBacteria" id="AFK06943">
        <property type="protein sequence ID" value="AFK06943"/>
        <property type="gene ID" value="Theba_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1255"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027795_0_0_0"/>
    <dbReference type="OrthoDB" id="44644at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028991">
        <property type="entry name" value="KamE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036843">
        <property type="entry name" value="KamE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16554">
        <property type="entry name" value="OAM_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="5">
        <location>
            <begin position="593"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="729" mass="81188" checksum="5A247CD0E67086AB" modified="2012-07-11" version="1">MLPVNEKLRVEEILKDLEHYAPKRKGWTWRKKLPEGTKVDGFYYDEISEPLKKSVGLPASHYFDNIDPQPDPVITSEIASGRFEDDVRRMRMAAWHGADHIMVIRTLGQSHIDGLIEGTPEGIGGIPITRKQLRATRKALDIIEEEVGRPINFHSYVSGVAGPEIAVLFAEEGVNGAHQDPQYNILYRGINPLRSFVDAAVAKKIMASVDMLQIDGAHNANASAKKAWKVMPELLVQHAINCVFSVKAGMKKDLISLSTVPPVVSPAPEFKLNFIYALTVRELFKEYRFRAQMNTRYIESDLVDATRIHVLDTLISRLTKADIQSTITPDEGRNVPWHVNSIRGVETAKHTLVALDGIKDLLKVNEEVVRPNIRELKMRAILMMEEILEVGGYFEAAEKGFFVDNGLYPERNGDGIARPKDGGIGAGTVIPRDADYFAPVCEHFGYNRIPEDLSSPDEPIGACTLHDRSKIKYIDELDESDNVNLRITQQLEDREKRLISPEVEWWGDGWVQLDMTIPDDPEHSEAAAIEIAKRMGFTDPSVISRTVLHPVEGTYLELKAKVPFKIVRDSLQLPQKPDLLSEEEITAFIDEHPMRVVAGTVGNDEHSVGIREILDIKHGGIEKFGFKYTYLGTSIPPEKFIDAAIETGADAILVSTIITHNEVHVDNMTKIAQLAVEKGVRDKVIIISGGTQITNDLAVSCGMDAGFGRGTKGIHVASFLVKKKRELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W2</accession>
    <name>I2F4W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486629.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1277"/>
    <dbReference type="EnsemblBacteria" id="AFK06965">
        <property type="protein sequence ID" value="AFK06965"/>
        <property type="gene ID" value="Theba_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1277"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="3">
        <location>
            <begin position="142"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="317" mass="34399" checksum="AF35D4A98265B25B" modified="2012-07-11" version="1">MKALVFDGTLKLLDVPLPVRWPGTSLVKVNLAGICNTDLEITRGYMDYHGILGHELLGTVIESDSAILSGKRVTTEINIPCKTCDLCKQGLLKHCRNIKTVGISDYPGVFAEYAVLPDENLHVIPESVSSLKAVFTEPLAAAAQVFESVELSPDQRVCLIGDGKLGLLISMALSAKKIEHRLVGKHSQRIGLLGSSSGALFLSIDEAESYDRHFDIVIEATGNSSGLAQALRLVRPQGKIVLKSTYQGIPSFDVTSVVVREIELIGSRCGPFDKAISMLEEGTVDPTTLIENIFHIDESLKAFEAAKKSLKVIIRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W9</accession>
    <name>I2F4W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730948.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1284"/>
    <dbReference type="EnsemblBacteria" id="AFK06972">
        <property type="protein sequence ID" value="AFK06972"/>
        <property type="gene ID" value="Theba_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1284"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_1_0_0"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="37100" checksum="39DB334D4EE956D8" modified="2012-07-11" version="1" precursor="true">MPWFFSIGHSRSLSTSSLLSLFCPLLCWFIILLMSAIVSKILTFFVLIGTGFIMKKSNLADDLFTKGISRFVLYITLPALIVESMNFDFSYEMLSNSVILLMAGGVLYLFLWILGIASSRVLRLTGDVRSVFRYAVLFGNVAYMGYPVVELVIGKEGVFYSAVFNIWFNILTWTVGIRIMTGKTELSGKKAFLNPGMISVFIGLVLFFTPLKLPVFLDEALALLGESTIPLAMIVAGIILASSKISTILKGRTIIIYSLLKLCIAPMIVFLFLSFLRLPQTVEKVLIIMSAMPAAANTSIFARLFDSDFELSSRLIASSTLFSLISIPLIISFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X8</accession>
    <name>I2F4X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730957.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1293"/>
    <dbReference type="EnsemblBacteria" id="AFK06981">
        <property type="protein sequence ID" value="AFK06981"/>
        <property type="gene ID" value="Theba_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1293"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_19_1_0"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="21330" checksum="DC9BD7E724193C74" modified="2012-07-11" version="1">MENYHSESPLREITLRNGDSCFFYRADIGDSERIIEYINSVAVESDYLSFGRGEFTMSSEDERRLISSFKERSNCLMAVAKCDQSIVGLITMQGGSRKRIYHWAEIALSVSMKYWGMGIGRVLIELAVEHAGRNGITRIGLKVRTDNDRAIALYRKMGFEIEGKLKKFMRVNDDYFDFYQMGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y9</accession>
    <name>I2F4Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486683.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06992">
        <property type="protein sequence ID" value="AFK06992"/>
        <property type="gene ID" value="Theba_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1304"/>
    <dbReference type="HOGENOM" id="CLU_2617909_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="78" mass="9435" checksum="F8B3BA5783A00BA9" modified="2012-07-11" version="1">MYYRSKENGIFNFNLYSNYKAVGSRYIATRPTEQEDVVEELNSEDDAKLFEEFIWASLQRVRDYIDFKDFDSFCHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F506</accession>
    <name>I2F506_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486715.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1321"/>
    <dbReference type="EnsemblBacteria" id="AFK07009">
        <property type="protein sequence ID" value="AFK07009"/>
        <property type="gene ID" value="Theba_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1321"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036192_0_0_0"/>
    <dbReference type="OrthoDB" id="1636709at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="421" mass="45729" checksum="9CD33DF022EDAB98" modified="2012-07-11" version="1">MKRLNDIDKANSIAFERLLKAEPQIVGLGMAKEFIPNFGEKMILHAGPPITWERMSGPMIGAITGAILYEGWAETPEKARALASKGEITFEPCHHHNSVGPMAGIISPNLPVWVVEEKNSGRRGYATLNEGLGKVLRMGAFSEEVIERLNWMREVLYPVLRNGVRKYVEDNGGLNLKSLISQSLHMGDELHNRNRAATSLLIRTLVPSLIDAERGNHNLSRVVKFMAGNDHFFLNPGMAAAKASLDSVGYVEGSSMITIMARNGTDFGIQIAGIENEWFTCQAALPDVLLFPGFTKDDVNRDIGDSAIMETYGVGGFALAAAPAIVQFVGGTPQDAVNYTKEMYEICVGENKHFTIPVLNFRGTPTGIDLIKVVETGITPILDTGAAHKEAGKGQVGAGIVRMPSEAFVKAAEAFVEKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F507</accession>
    <name>I2F507_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486719.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1322"/>
    <dbReference type="EnsemblBacteria" id="AFK07010">
        <property type="protein sequence ID" value="AFK07010"/>
        <property type="gene ID" value="Theba_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1322"/>
    <dbReference type="eggNOG" id="ENOG5033NQU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205694_0_0_0"/>
    <dbReference type="OrthoDB" id="2085141at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="59" mass="6858" checksum="7520DB78EEE70A2E" modified="2012-07-11" version="1">MSFKDLLNSGPKVINLGMERFYLDLLEQEVPAVKVNWRPPLAKSSLMDRLRKLRGEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F515</accession>
    <name>I2F515_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486735.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1330"/>
    <dbReference type="EnsemblBacteria" id="AFK07018">
        <property type="protein sequence ID" value="AFK07018"/>
        <property type="gene ID" value="Theba_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1330"/>
    <dbReference type="eggNOG" id="COG1507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097805_2_1_0"/>
    <dbReference type="OrthoDB" id="1922611at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="20064" checksum="44376A8C8A421427" modified="2012-07-11" version="1">MESNNIEKKIVSLQLGRAVKNDFTVARLCNWGFPQVIESSLISDGRPFPTLFWLTCPFLKGEVSRLESKGMISHLEKRIEQDKSFATAFLGAHRETTLLKEKILCEASVSGESRRLLLDRGIGGIRNLKKVKCLHLHLANYLGGIDNPVGREVWNLLEKKQCSSTKIICRELLRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F596</accession>
    <name>I2F596_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731044.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1411"/>
    <dbReference type="EnsemblBacteria" id="AFK07099">
        <property type="protein sequence ID" value="AFK07099"/>
        <property type="gene ID" value="Theba_1411"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1411"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254711_0_0_0"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="24721" checksum="AEE7B5F300B6120A" modified="2012-07-11" version="1">MKQHYDRGKLEQEFDNLPEASPIADIDPFKGDIIAMVGALALDYLDLDSGDTLLDIGTGRGRWAVAASPYCRKVIGIDISRRMLEDARSNIASAGVENVEFFRGSFENPCEEVNLSRMNINKVVAIYSLHHLTDPMKMEAISKLTQILKRPGRIVVGDIMWFDDPGKHRDAWDEVYFDDNELDHPASISFMKEVFQHSGANEIEVVQIHPLVGLISTTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A1</accession>
    <name>I2F5A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731049.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1418"/>
    <dbReference type="EnsemblBacteria" id="AFK07104">
        <property type="protein sequence ID" value="AFK07104"/>
        <property type="gene ID" value="Theba_1418"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1418"/>
    <dbReference type="eggNOG" id="ENOG502ZW86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2106049_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="115" mass="12774" checksum="40A6BB1C20F9F00B" modified="2012-07-11" version="1" precursor="true">MKKGLSMVEMIITMAVVAIIIVTVFQIFLTIHSTLSKSNARMKDYTEIRYEITNLWRSGGANDYGLEVSEDGSFFDRLAAEGVSSGLLEKLEAAISIMNVQDKSREATFTAVMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A8</accession>
    <name>I2F5A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1425"/>
    <dbReference type="EnsemblBacteria" id="AFK07111">
        <property type="protein sequence ID" value="AFK07111"/>
        <property type="gene ID" value="Theba_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1425"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="355" mass="38695" checksum="0B879E2880BAC339" modified="2012-07-11" version="1">MRKSDRVTIKQVADYAGLSAATVSRVLNGSRPVQEDLKIKVWDAVKKLNYKPNVGARFMKGQTTNVIGMLVPDVSQPFFSAMIAGAILKAGEIDHVIIISTSDGKRELEKAAIDSLSRTVVDGLIYCPVSTGDPLPQIESFKELPIVVVGRRNVFKSKPHVYTDNVKGGYLATKYLLRLGRKRVGFLAGFWSSPCTIDTIGEVASSEDAGKYTTLDRYMGYRRALEEEKIEYDPSLIVICGYDYEAGYIGARELLERMVEVDSVIAANDLVAAGVIGFLTDQGINVPDQVSVVGYDNNLIAPITIPTLTSVDQDPRTLGAESVVALSKILSGKEVSDTIIDVKLTIRNSTSVMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C4</accession>
    <name>I2F5C4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">Theba_1441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486963.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1441"/>
    <dbReference type="EnsemblBacteria" id="AFK07127">
        <property type="protein sequence ID" value="AFK07127"/>
        <property type="gene ID" value="Theba_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1441"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_1_0"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="142" mass="16570" checksum="4EEBEA8696F10205" modified="2012-07-11" version="1">MEIQIQNKTSKKIEESRISNIVEKVVKAELGERKIGMLNLLFTDDSEIRSINKEFRHRDEPTDVLSFQYGLEEEIVGDIVISLERISEQAGEFGNSFEEELYYILIHGVLHVLGHTHEGYDDEGEEIFSLQRNYYKRFVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D1</accession>
    <name>I2F5D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+ transport system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486976.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1448"/>
    <dbReference type="EnsemblBacteria" id="AFK07134">
        <property type="protein sequence ID" value="AFK07134"/>
        <property type="gene ID" value="Theba_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1448"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143561_0_0_0"/>
    <dbReference type="OrthoDB" id="2013450at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="148" mass="16495" checksum="71507E1FAED96106" modified="2012-07-11" version="1">MVVPLSSMCEGEKGKIRKLELPPVTRERLCGLGFVTGEEIQLVKVAPFGDPKVFRIKGSDITLRDDISMWILVETSSFPLSYVSEGDYWVSLINGGMGFRQRLRMIGIEEGIKISVIGNLGKRIEVSAKGIRSVLSRGQAMRIIVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E5</accession>
    <name>I2F5E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-terminal processing peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731082.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1463"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="AFK07148">
        <property type="protein sequence ID" value="AFK07148"/>
        <property type="gene ID" value="Theba_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1463"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_3_0_0"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="412" mass="45529" checksum="660EE305500897CB" modified="2012-07-11" version="1" precursor="true">MEKNRVLKILLTVSILVAVFFLGALSSMTDDEMFEKFSPVFEILTYIDRNYYDIEKVDYDAILNETLTGTMRGLDDPFAWYFDPVQTKENELDTTSKYGGIGSTVQYNIEFDCLEVVAPMAGSPSERVGLRAGDLILTIDGVPVSEVGYYGAVNMLRGDPDSQVVLEVYRESVENPFFVEITRAFIEIKSVKTELLTVEDTEISYIQITGFNAPTYDEFQDALNLSRESGAFIIDLRNNPGGLLQSVLNISSLMLPKGKRVITIRYRDGQEEVYNSWGSRYNSYFTDKPIVVLVNDGSASASEILTGALKDHGLATVIGTTTFGKAAVQTVFNLSNGGEIWLPTAHYFTPNGSDIHLQGIEPDIIVEAGEQAPSEDGRELTLSTATVDVEHDLQLSKAIETILEKLGVKVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G5</accession>
    <name>I2F5G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6">6.3.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731099.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1486"/>
    <dbReference type="EnsemblBacteria" id="AFK07168">
        <property type="protein sequence ID" value="AFK07168"/>
        <property type="gene ID" value="Theba_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1486"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_1_2_0"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="9">
        <location>
            <begin position="97"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="8">
        <location>
            <begin position="313"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="441" mass="48910" checksum="B4C04E97E939FC44" modified="2012-07-11" version="1" precursor="true">MISKSSVEEFLLQTEDRNIVIDSRKVSAGDVFIGLKGEKVDGNDFVGEALSKGASLVFSDKAFDDQRVLRVDDTNEILIEAAKSILSKSKLSNRIGITGSNGKTTTKEISSFFLSKLGRVFKTAGNLNTEIGLPLSLLENRRELFSAQYGVFEFGTSTKGDIEKLVGIVQPDIAVLLNVGSAHVGNFKDIDELLQEKLSIFKSKRLSRAVLGGCDERLREFSKGLPVEVLLFGKEDVDFSIVDFAYDKGDTMLHFFCDGDRFVRLRGIWSYGQLLDLGAAYLVARLVGVEEPSVFLNDYKLPFSDRFTVSILKGITVISDFYNSSLESWESAILSIEKLRSSRKIAVAGSILEQGREEKRTHERLGELLSKFDETVLFTRDMAINAASKNVKPALVSDSEEEIAAWLHRNVRSGDLVFFKASRAIALEGVYKSFMELIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G9</accession>
    <name>I2F5G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">Theba_1490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487038.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1490"/>
    <dbReference type="EnsemblBacteria" id="AFK07172">
        <property type="protein sequence ID" value="AFK07172"/>
        <property type="gene ID" value="Theba_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1490"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_1_0"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="356" mass="40159" checksum="0CD0FB704C99421C" modified="2012-07-11" version="1" precursor="true">MKKLKIAFCGGGTGGHYYPAVAILHALSRVREIELLYFTVWGKIDDRSVDRDFPGVRKMSLKLTGLKRPLYSPANASIFFSHLRTERSVKRQLAEFSPDFLFSTGGYVSYPVVRAAKSLEIPVYIHEQNSIVGIANKRLAKYAKRFFISFEESGRDLELPKERIVFSGNPVRESKITRNEVMKRFDLPDNKPLIVVLGGSLGSELINRACEGLYEEIQSNDCELSFLHSTGDESSAISLRRFPFVRAFSYIEDLTDAIACADLVVSRGGATTIAELQYFGRKGIIIPWSGAAENHQFYNARSLERVGLGYVILEENLTSTALRIAIKEMLHRQISYKPPRRPVEIVLDNILREESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J9</accession>
    <name>I2F5J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein, YruB-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487118.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1526"/>
    <dbReference type="EnsemblBacteria" id="AFK07202">
        <property type="protein sequence ID" value="AFK07202"/>
        <property type="gene ID" value="Theba_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1526"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_9_3_0"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="79" mass="8877" checksum="B1F7E9A2F786C447" modified="2012-07-11" version="1" precursor="true">MNAKVIVYSTPSCPWCKRAKDYFRTNGIPFKDYDVSKDRAKAEEMVKKSGQMGVPVITIGSQVIVGFDKNRIDNLLGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L1</accession>
    <name>I2F5L1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 4 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4 5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487135.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1538"/>
    <dbReference type="EnsemblBacteria" id="AFK07214">
        <property type="protein sequence ID" value="AFK07214"/>
        <property type="gene ID" value="Theba_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1538"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_2_1_0"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="88" mass="10162" checksum="B2AEB8E831D16B7C" modified="2012-07-11" version="1">MRTVRIRVYGRVQGVGFRYYALYTARSLGITGYVRNEPDGSVEIVGSGRDPDIEAFIESIDRGPTYANVTKTEIEELPFMRFEYFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M5</accession>
    <name>I2F5M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">Theba_1556</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487163.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1556"/>
    <dbReference type="EnsemblBacteria" id="AFK07228">
        <property type="protein sequence ID" value="AFK07228"/>
        <property type="gene ID" value="Theba_1556"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1556"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_0"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
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        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
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        <property type="entry name" value="ruvC"/>
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        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK07228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="168" mass="18921" checksum="FA763C8D81FC8C2F" modified="2012-07-11" version="1" precursor="true">MPACVRVLGIDPGFGAVGYGVVEMRSSRIDLVSYGAIRTEPQEPIPDRLLKIHDRLEELLLEFRPDESAVEELFFFRNVTTAIQVSEARGVILLAMRRHEVPIFEYTPHQVKLAVTGYGRAEKGQVQRTLKTFFRMEVNPRPDDAADALAVAWCHLTSRKFPGGVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N5</accession>
    <name>I2F5N5_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">Theba_1566</name>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="526" mass="60039" checksum="41B75F8972AF0118" modified="2012-07-11" version="1">MEDNTEIKDRVVELLTEYMSVPESDLSLKITYLNKAISSLNHQGNTLAAHGIVEREIRRFDNCDSLEMAVLLNSMIKLSALVGDFAGAVEYSRRAQTICREKEEEGLLTRVLINTSGIYFKMKEYDKAFSNANKALQMARKNGDETNTACCLNNIAVILENSETDKSGIPYLEEAILIKEKNNMKDELPNSYLNLAELYYNSGKKKEASELLQRATTMARENGDERALTETMKYRARFLKAEGELFSALELLTGVSEYHQKNGNNTELLDILNEISSIHELMGNANEALQTFKLITELNRTIFKEEQARSLAQLESSFEARENLREMHSLLEQNSELRRVNEEISEKNNELHDMKRRLEKTNKLLERQAETDSLTGLLNHRKMRTTVENEIARAERYGTPLTMIMIDLDNFKFVNDSYGHLKGDEVLSEIGRIIKSSIRKNDFAFRYGGEEFLVLLPLADLDKATEVYSRLKESFREELEITVSFSAGAREWNGESADKYIAVVDKLLYEAKTKGKDRLETSQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R6</accession>
    <name>I2F5R6_9BACT</name>
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        <submittedName>
            <fullName evidence="2">CRISPR-associated protein (Cas_APE2256)</fullName>
        </submittedName>
    </protein>
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    </gene>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1605"/>
    <dbReference type="EnsemblBacteria" id="AFK07269">
        <property type="protein sequence ID" value="AFK07269"/>
        <property type="gene ID" value="Theba_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1605"/>
    <dbReference type="eggNOG" id="COG4006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794117_0_0_0"/>
    <dbReference type="OrthoDB" id="1067883at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="49"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="349" mass="40174" checksum="367B1B5F95720959" modified="2012-07-11" version="1">MGRQRRVITNVGGTIWFNLKKMYASPDSELSSSAIVSYLRKMSEDELKKISPEINGLGTFGVNKDDLLIFIATNTDVSKACMEALTELYRSRGINVITRVVEGLTDDSNTAFKKGIADYVDLIIGLFDNGEQWSYDNYFNATSGYRSLIPYTTIVAAVFDSRVFYLYENSPHLLELPPFPINFDFEIMEKHSSFFEKVDNDCVPVEEARKEFGNELFTKIVPQILLEEDGLVYLSNFGKILWGRYTVSNPEIYLSDSAQKVIDKDPVYLEYIKKMLRNEAEAEHQLHEYVGDAQCYKFPAKGVRVFYIRHGEEPLKIATILRNHDEYERYIRTEQHEAGLNYTKTRISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S2</accession>
    <name>I2F5S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR type III-B/RAMP module-associated protein Cmr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731174.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1611"/>
    <dbReference type="EnsemblBacteria" id="AFK07275">
        <property type="protein sequence ID" value="AFK07275"/>
        <property type="gene ID" value="Theba_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1611"/>
    <dbReference type="eggNOG" id="COG1769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044328_1_0_0"/>
    <dbReference type="OrthoDB" id="1656967at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010165">
        <property type="entry name" value="CRISPR-assoc_prot_TM1793"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019117">
        <property type="entry name" value="CRISPR-assoc_protein_Cmr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09700">
        <property type="entry name" value="Cas_Cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01888">
        <property type="entry name" value="cas_cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="351" mass="39143" checksum="2E9FD0B79AF5801B" modified="2012-07-11" version="1">MKLNAVYFTPEDWICFRESTVFQSGGDAKTGLPKIETFLGAIKTALIKKAGENPLNLSSELKEIVGDSENPGSLRIWGPFIFNQVNSEIRHYFPSPNGIYRVEEGGEFKLMMPHCSVETEINGKTLKLTWIPSSVEGIETFDGSLIEMNEVSNLQRKLPFSILQSKEISQKLYQVESKVGIALERERKNAEESMLYTLSYYRFKPGAGFFVFADEYTAKTISGLSNVFIGGKTRAAEVDVNTIETEIFNVSQSSKTAICLVTPSVFSNGSLPSDMKIAGCDIKSANIQRKIAVSGWDLAKNQPKPIKHYVAPGTVYYLEGTLDNIQNISSESQDFGYGKYFTVDWDYIGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6A4</accession>
    <name>I2F6A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase 27 kD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731287.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1806"/>
    <dbReference type="EnsemblBacteria" id="AFK07457">
        <property type="protein sequence ID" value="AFK07457"/>
        <property type="gene ID" value="Theba_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1806"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_1_0"/>
    <dbReference type="OrthoDB" id="1735902at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="171" mass="19753" checksum="0C1009DDB00B1AF2" modified="2012-07-11" version="1">MNSMNEILGEVTTIAGELSVKEVTARESIVSVEASRLNAVLELLKRRGFSHLSLITGVDRIKDGIFEVFYTLFRWETGETLLVKSSISRDEPVISTVMHLWPTARFYERDVHEFFGIVFDGNPDLKPLILENWKEMPPMRKDFDPQKYSNEHFPDRHYEAEFLAEGGDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B2</accession>
    <name>I2F6B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731295.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1814"/>
    <dbReference type="EnsemblBacteria" id="AFK07465">
        <property type="protein sequence ID" value="AFK07465"/>
        <property type="gene ID" value="Theba_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1814"/>
    <dbReference type="eggNOG" id="ENOG502Z80Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075784_0_0_0"/>
    <dbReference type="OrthoDB" id="857043at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029433">
        <property type="entry name" value="DUF4438"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044909">
        <property type="entry name" value="TM_1086_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044910">
        <property type="entry name" value="TM_1086_SG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14505">
        <property type="entry name" value="DUF4438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="29996" checksum="EF3C9588917FF353" modified="2012-07-11" version="1">MRTNKASVVKISVSGEVAHPLRRSPFRLEVDGTPRLFPGTGGITYNFALGDSAFKMVGDHVEPDVSTKNPDNDKNAAYVGYSCIGNSATLISGDAKGEKGIVIGKHGGINHVLIHFKEDIKKKMAIGDKIQVVGFGQGLVLEDYPSIRVYNIDPELLDRIPVGEGDGKIHFPVRAIVPGYLMGSGSGSGDPSGGDYDIITNDRALIKKVGLDRLRIGDFVALENHNDSFGLGGYMEGSVTIGVVVHGDCIITGHGPGVTVVMADGKGIIIPEISEKSNVIDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E3</accession>
    <name>I2F6E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1846"/>
    <dbReference type="EnsemblBacteria" id="AFK07496">
        <property type="protein sequence ID" value="AFK07496"/>
        <property type="gene ID" value="Theba_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1846"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="288" mass="32770" checksum="963515655AC31A7D" modified="2012-07-11" version="1">MVSEEITKIKDDLSPAYKRIATFILKEYSQVGFMSIEELSSMAGASKASVVRFSRRLGFSGFNELKKTIQHELRKRLLPYEKIATTELDRAPVENQLKLLRQNEINNLKNTLSGIGEEELHKWIDTIRAASNIYFGGFGATKHVVSLMRYTISVLQRKPTWLLSGSVSDFSFKIKLMERNDALIVMTFPPYSKEVEYMVDFALERNVRTLLVTDSVDCPVYSKAYSSILCENNSLLFGNSFVGPIAVAEMIGNFIILSEKKTGMEEMKRLFEVEERGYKAIKIDGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G6</accession>
    <name>I2F6G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="13" type="ORF">Theba_1869</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731325.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1869"/>
    <dbReference type="EnsemblBacteria" id="AFK07519">
        <property type="protein sequence ID" value="AFK07519"/>
        <property type="gene ID" value="Theba_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1869"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_0"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:tRNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
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        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
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        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
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        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="334"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="473" mass="55046" checksum="FEAD975DE16632FD" modified="2012-07-11" version="1" precursor="true">MVRCRFAPSPTGNLHVGGVRTALFNWLFAKNQNGSFVLRIEDTDTERSEKRFEDQILSSMKWCGLNWSEGPDIGGEYGPYRQSERVALGFYDKYAQELVERGHAYYAVYKKSNQEDVLRISMEMPDISGDEVYTIKFRIPEGKTEFSDLSKGKMSFENENFSDFIIIKSNGFPTYNFAVVVDDHMMDITHVFRGEDHLTNTPRQIMIYRALDWEPPTFMHIPLILGSDRAPLSKRHGHTSVDHFREEGYLSVGLMNYLALLGWTVDEEIFDYHEKVKDFIPSDISNKGVVFDYEKLEWINGKHLRLLDPEELMIQFGLWLKFTGRFDYYAIIESDQFYSREVLTMCREKINTLEQLFDFSAPFFSDELDYQEEYVSKYLQNNWSKDLISAAIRKFEDSLDWSVEGVEKTVRELADEKIASKKNTFQTLRGGVTGRLVTPGLFETISVLGRDRVLERLENLLEMIEYEEGNLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G7</accession>
    <name>I2F6G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731326.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1870"/>
    <dbReference type="EnsemblBacteria" id="AFK07520">
        <property type="protein sequence ID" value="AFK07520"/>
        <property type="gene ID" value="Theba_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1870"/>
    <dbReference type="HOGENOM" id="CLU_1852834_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="138" mass="15538" checksum="973876D2FC2C5CF4" modified="2012-07-11" version="1" precursor="true">MRKGISLIEMVVSLAVSAILLISVFKIVNMSIAMSFNIVRETKSYMSLSRTFDVIERDLNRSIGNFSWGTSFISFDAIVDGRYKRIRYYVSGDRIIRRSGNSYNTVTEFVKSAGFYGEEGSVRFFVDEGEILIGIEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H5</accession>
    <name>I2F6H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731332.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1878"/>
    <dbReference type="EnsemblBacteria" id="AFK07528">
        <property type="protein sequence ID" value="AFK07528"/>
        <property type="gene ID" value="Theba_1878"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1878"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_4_1_0"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="217" mass="24643" checksum="FFA55882F1328EF5" modified="2012-07-11" version="1">MLDTVDLFNDLSSDEKSEVLSASRTVRFQPDQVIYTPDDLCDSLCIVLKGRLRIAKVLPSGREQTINYIEKNQIFGEALAFAGRKCASHVFAEEDSEILSIPKRALLYAFKNKRFLFSYLKSISEKTLNLSYIIELLSLSTVKKKLASYLLELSLEKGSNSFELPHTKKTLANLFGSTREAVSRNFSELRKDGIIFMPDRNSVEIKSSKQLEKILFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J4</accession>
    <name>I2F6J4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731349.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1899"/>
    <dbReference type="EnsemblBacteria" id="AFK07547">
        <property type="protein sequence ID" value="AFK07547"/>
        <property type="gene ID" value="Theba_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1899"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_0_0"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="327" mass="37691" checksum="D2147F857ABFF7CA" modified="2012-07-11" version="1">MRILSGMRSTGRLHLGNFITLEKWKELQDQGNECFYFVANWHGLTSHIDETSSFYDWSLDIVRTYVSAGLDPEKSVLFIQSAIKEHAELFLYFSMLVSVSRLERVPTYKDQKEQITDRDLSSGGFLLYPVLQAADILMYLATGVPVGEDQIYHVELTREIARKFNNQFAEVFPEPEPILAKVPKLPGTDGRKMSKSYGNYILIDTDEKELWKMIAPMMTDPARMRRTDRGDPEKCPVWDYHKAFTTSDEEKRWVVEGCKTAGIGCIECKRLLHKNLVQRLSPVWEKLSHLKENSDELFEIIEDGNKKAREVAKGTMKRVIEATKLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V2</accession>
    <name>I2F6V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731439.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2012"/>
    <dbReference type="EnsemblBacteria" id="AFK07655">
        <property type="protein sequence ID" value="AFK07655"/>
        <property type="gene ID" value="Theba_2012"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2012"/>
    <dbReference type="eggNOG" id="ENOG5032XQP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107962_0_0_0"/>
    <dbReference type="OrthoDB" id="1441319at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="179" mass="20491" checksum="83E5FE06B8944553" modified="2012-07-11" version="1" precursor="true">MNWYVDFVRDFPFLSAIIQFSILGTLGDFVSAKIARFKTPFPPRIAFMKALEWAFLAIFIKIAFIGYQGFVSALVINGVLPSFFVENLLLNAFARSLSMNLQFGVFLVLFHRLLDNFVLQTVNWKNLDKALISLIWFWIPAHTLTFALPKDFQIGLAALWSFMLGLLLSLFSRSPQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W9</accession>
    <name>I2F6W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731453.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2029"/>
    <dbReference type="EnsemblBacteria" id="AFK07672">
        <property type="protein sequence ID" value="AFK07672"/>
        <property type="gene ID" value="Theba_2029"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2029"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_0"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="390" mass="44332" checksum="BBFD3C81D7596A9B" modified="2012-07-11" version="1">MKYDFDRVIERRGTNCIKWDHADLFFGRNDLLPMWVADMDFESPPEVVEAIVSRAKHGIYGYTARSKAYYESIVNWLYRRHGWKIKEEWIAHAPGVVAAVHIAIMALSHPGDRVVVQTPVYYPFFKAINETGRQMILNPLKESDGRYSMDFEDLERKVDSRTKIIILCSPHNPVGRVWRRDELSRLGEICLNRNIKIISDEIHSDLVFGNNKHIPTAMISDEVSSITLTCVAPSKTFNLAGLSSAAVISSSSELLGEYSSMMSTVGAGMSNVFGTVALETAYNNGERWLEQLLEYINGNFVYMRDFLKTNFPELRVADLEGTYLAWIDFRNTGMSVEELRSFLYEKAKVGFEDGSIFGEEGEGFMRVNLACPRAIVEEAMKRLITARKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F721</accession>
    <name>I2F721_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731501.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2090"/>
    <dbReference type="EnsemblBacteria" id="AFK07724">
        <property type="protein sequence ID" value="AFK07724"/>
        <property type="gene ID" value="Theba_2090"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2090"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061796_1_0_0"/>
    <dbReference type="OrthoDB" id="1169054at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="37816" checksum="0C1E1C662B3ABDD9" modified="2012-07-11" version="1">MGNRPVTLFTGQWADLTFEEICKKASSWGYDGLEIACWGDHMDLEKAAKDPNYVEKRKEILEKYNLKCWALGAHLMGQCVGDLYDVRLDGFAPASCKGNPEKIRAWGIEQMMYAPTAAKNMGCYTVTGFTGSPVWKFWYSFPQTTEKMVEDAYREIVDLWTPIFEKFDAEGITFSLEVHPTEIAFDYYTAKRLLEVFNYRKTLGFNFDPSHLIWQGVKPHLFVRDFAERIYHVHMKDAAVTLDGRAGILGSMMTFGDTRRGWNFRSLGHGHVNFEEIIRELNNIGYSGPLSVEWEDSGMEREFGAKEAAEFVRKVDFEPSNIAFDDAMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F741</accession>
    <name>I2F741_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731518.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2110"/>
    <dbReference type="EnsemblBacteria" id="AFK07744">
        <property type="protein sequence ID" value="AFK07744"/>
        <property type="gene ID" value="Theba_2110"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2110"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_3_3_0"/>
    <dbReference type="OrthoDB" id="1563802at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="136" mass="15442" checksum="D2B3654B1D6C632F" modified="2012-07-11" version="1">MKFEDFFVGQSFSTRRKITAEMVDSFANLTGDRNPVHTDEEFARKSRFGRRIAHGMLSVGIISAILGNEFPGPGSIYMKQEVRFLKPIFLEEEVLITIEILEIKVEKKRLSVRTTVEKNNGEMAVDGEALLLFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F790</accession>
    <name>I2F790_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731561.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2160"/>
    <dbReference type="EnsemblBacteria" id="AFK07793">
        <property type="protein sequence ID" value="AFK07793"/>
        <property type="gene ID" value="Theba_2160"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2160"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153062_2_0_0"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="103" mass="11538" checksum="5F2C47D9F655E80E" modified="2012-07-11" version="1">MERIFEHPLISFKRGEIITFFFEGRELSAYTGETIAAALHANGIKDLRYSPIRNRPQGLFCAIGKCSSCLMEVDGKPNVRTCITPVKPGMIVRRQHGKGEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C7</accession>
    <name>I2F7C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methylase, putative, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731593.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2197"/>
    <dbReference type="EnsemblBacteria" id="AFK07830">
        <property type="protein sequence ID" value="AFK07830"/>
        <property type="gene ID" value="Theba_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2197"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_0"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="247" mass="27577" checksum="F9BB610BE43DBBCD" modified="2012-07-11" version="1">MYLHGRNVLRELLTVDSSALNVKRIVFTNQKNVDSQLLELAEESKARGFRIEEMAPEKLANLCREKKHQGVVIDLKQFPYSDSEELLRAIEEQRTATIVLLDQIQDPHNLGAIIRTSVAVGADAIAITSSNSAEITPSVVKVSAGLAFKIPIIKIINMAQFEEILKEKGFWIYASDMEGIPYYENEYSEKSAIVFGNEGKGVRRLVKERSDRLISIPMEDTVDSLNVAASAAIILFDRRRQLALGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C8</accession>
    <name>I2F7C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mini-ribonuclease 3</fullName>
            <shortName evidence="2">Mini-3</shortName>
            <shortName evidence="2">Mini-RNase 3</shortName>
            <ecNumber evidence="2">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mini-RNase III</fullName>
            <shortName evidence="2">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrnC</name>
        <name evidence="4" type="ORF">Theba_2198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MrnC RNase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731594.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2198"/>
    <dbReference type="EnsemblBacteria" id="AFK07831">
        <property type="protein sequence ID" value="AFK07831"/>
        <property type="gene ID" value="Theba_2198"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2198"/>
    <dbReference type="eggNOG" id="COG1939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091169_2_1_0"/>
    <dbReference type="OrthoDB" id="1939897at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005520">
        <property type="entry name" value="UCP005520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="136" mass="15655" checksum="CAFF95FB860C8CD4" modified="2012-07-11" version="1">MNTYNNGNDKRDNLFSFSVSPDQLSLDSLAFLGDAVYSLYFRLNTLPQARRRAGHQHNIVKDYVSASGQRKALEEVADLLDEEEKEIVRRGYNSRGSKKHGDDEDYKMATAFEALIGYLFLEGKTERIRELFERVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C9</accession>
    <name>I2F7C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alaS</name>
        <name evidence="11" type="ORF">Theba_2199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731595.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2199"/>
    <dbReference type="EnsemblBacteria" id="AFK07832">
        <property type="protein sequence ID" value="AFK07832"/>
        <property type="gene ID" value="Theba_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2199"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_0"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="10">
        <location>
            <begin position="4"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="869" mass="98433" checksum="7C445F48E6178EB3" modified="2012-07-11" version="1">MKYMTGAEIRESYLKFFESKDHKRLQSASLIPNDPQLMFTVAGMVPFKPIFWGKIEPTYRRVTTCQKCVRTNDIENVGRTPRHQTFFEMLGNFSFGDYFKRETIKWAWEFVTEYLNLPENRLWVSVYLDDDEAFSIWRDEVGIPEKKIIRLGKKDNWWGPAGPSGPCGPDSEIFIDRGHGDNCPDPENCSPACDCGRFLEFWNLVFTEFNQDEEGNLTYLERKNIDTGFGLERAASILQDVDSNFDTDLFIPIIKKIEEILGIKYKEKPGSDISIKVIADHARSVAFMVSDGILPSNEGRGYVLRRILRRAVRHSSLLGYSSPFLYRIVETVADHMGNVYPELRQRLSFTQEITLKEEERFLSTLVNGEKRLKSVLVDKKELSGPELFMLHDTYGFPLELVEEIVAGTGVTLDKEGYEREMALQRERAREAMGDREYLSNVEAYSTIFPVTGNSKFTGYSRFEDKSKIVAILKEGDAVETLSKGETGDLIFEKTPFYPERGGQVTDTGLIRTDNASAKVERVFIPYQEMIVHRAFVEEGALHVGDKAWLSVDEDRRKAITRNHTATHLLHAALRKVLGEHVHQSGSLVQPDRLRFDFSHFQPLSTDELNEVEEIVNEEILKAKVVDKAEKSFDEIKGQDVMALFEEKYGDKVRVISVEGFSRELCGGTHVDNTGEIGLFKILSDTSVAAGTRRIEAITGKTSLNYFRNLFNRQKTIREVLEVPEDLIIQRLQGVLNELKSGGQEIKRLKEKLLSGDSLMKDKKMIVNGTKLLIRRVENAPSSALRNGADVLLSKEGGGIVIIFNELEDSVSFVVKVEKKLTDKFNAGEIARKIARDLGGGGGGRPDFAQAGGKDLSKLQTLIERIDEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E1</accession>
    <name>I2F7E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">Theba_2213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487673.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2213"/>
    <dbReference type="EnsemblBacteria" id="AFK07844">
        <property type="protein sequence ID" value="AFK07844"/>
        <property type="gene ID" value="Theba_2213"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2213"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_0"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="123" mass="13536" checksum="39F9D1364949ACC0" modified="2012-07-11" version="1">MKKYAATHEWVSVEGKIATIGISDHAQDHLGDIVYVDLPEVGKSYKKGDVFCTIESVKAASDIYAPVSGKVVEVNEELDSSPEKINDDAEGEGWIAKMEISNESELDSLMDLEAYKKHCEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G5</accession>
    <name>I2F7G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731627.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2238"/>
    <dbReference type="EnsemblBacteria" id="AFK07868">
        <property type="protein sequence ID" value="AFK07868"/>
        <property type="gene ID" value="Theba_2238"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2238"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_1_4_0"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="242" mass="28079" checksum="21445F909E7CB5D9" modified="2012-07-11" version="1">MKSNDANDARERIIDASIELFSKRGFHATTTSEIAEAAGVTKGLIYYYFKSKEEILSHVVNSLLEDATSITMDFVQEGIIQMIKDGELDIEYERMKFSNEESAIVFVNRLLEYYERILDYLLENRLLLRVLMFESLKDSKHHNDLFRLLDLSRDVDSNPILKLISEADHDFTYSLDMELFKFFFSVMPLVTFAAYYDDLKERSMMSGDELRNSFLQSFREVLSSLKSGNEISLKTKRSNDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I4</accession>
    <name>I2F7I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731646.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07887">
        <property type="protein sequence ID" value="AFK07887"/>
        <property type="gene ID" value="Theba_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2258"/>
    <dbReference type="eggNOG" id="ENOG5033N1T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743519_0_0_0"/>
    <dbReference type="OrthoDB" id="2128087at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="341" mass="39036" checksum="9FF0F3715640819B" modified="2012-07-11" version="1">MLREIMISFLLEGDACASIKYRVQKEILKESQDTLNMRVLHSGILDDIRVKNIIENQKQDGWLGESFHGEDSMEASIRFLLERGLGSNDAVISRAFEALERDSSDFPREFKKVGSVLDSRGFGGSESIRAALFAQAGLEEKDFVRYEVEKALEAFDFVRSAGSLVEITESFNGRLVFKEDAIWPSIYHLRLLAFARGWRSEEGRKTVAGAVKRLAELSPIKHALLRHKSQLIAPASVFMDDFNSDMDKLDSKGWMMWFHRMELLARMGIADEVPEIKRQTDRLRSALRKSGAKFAEKLSHPYFTHWNSYTGLALEENWKSPSRRINDLTFRSLLILYNADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I6</accession>
    <name>I2F7I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2260"/>
    <dbReference type="EnsemblBacteria" id="AFK07889">
        <property type="protein sequence ID" value="AFK07889"/>
        <property type="gene ID" value="Theba_2260"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2260"/>
    <dbReference type="eggNOG" id="ENOG5030VCV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136683_0_0_0"/>
    <dbReference type="OrthoDB" id="1602438at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="162" mass="19159" checksum="2C6BFF8F346D5055" modified="2012-07-11" version="1">MDSMNDLIREYTNQLNTGRIQEAYRGIMSFMSDLRTYLTERYPNYVTGSLYFGYMDMTYFAFSPTALRDRKLKIAIVYLHKESRFEVWLGAINRKVQAKYIEFFRLKNIGQYKLSQVSPGVDSILESILSDRPDFDNPEELKKEIERKTIEFAESVTLMLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L4</accession>
    <name>I2F7L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amino acid racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731672.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2289"/>
    <dbReference type="EnsemblBacteria" id="AFK07917">
        <property type="protein sequence ID" value="AFK07917"/>
        <property type="gene ID" value="Theba_2289"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2289"/>
    <dbReference type="eggNOG" id="COG3457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060710_0_0_0"/>
    <dbReference type="OrthoDB" id="357103at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="34"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="410" mass="45423" checksum="D8190B0E9B0CFEED" modified="2012-07-11" version="1">MDFLDTIVRRNPSLIQTAVSMHQRNELPANSVVVDLDMVEENAVKILDAAAGRGIHLYFMTKQFGRNPEICRTLNNVGIDKAVAVDLEDGICLQKNGIRVGHIGHLVQIPKASIRYVLSSMAPEVITVFSYEKALQISEVAKDLGIVQNLLIRVVGKGDFFYPFQFGGIEEEDLLETVGKICELPSVKVVGVVSFPCFRFDVKARKTMPMPNLFTLKRTAETLEKELGLRITQINAPGDSSAQMMDQFRELGVTHVEPGNAFTGTTPWHAFEDLPEKPAWLYLSEISHVNGDNAYAIGGGLMSGDSPMGIWSTLYHNHRLNALSGNNSDSILQRKILAERSGYIDYYGTLYGNREVEFSVGDSVIYGLRNQVFVSRANVAIVKGIQSHKPVLLGIFDRLGNPIETSFFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S6</accession>
    <name>I2F7S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731727.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2355"/>
    <dbReference type="EnsemblBacteria" id="AFK07979">
        <property type="protein sequence ID" value="AFK07979"/>
        <property type="gene ID" value="Theba_2355"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2355"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549576_0_0_0"/>
    <dbReference type="OrthoDB" id="964385at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="197"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="269"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="419"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="496" mass="55387" checksum="BECA88D6062C19B1" modified="2012-07-11" version="1" precursor="true">MRTYRNRKLRFRKLMIFVAAISFIFLSTECIFKTVTLTMLEPDEGGEVQPLPGNHKYLINTSVDIQAMPDDGWDFDRWEVDEEFYSNEKETKLEMDSEKTIKAFFSRQPVTLTMEDEEGEGSISPVPGEYQFDYSTLVGLSATPTEGWEFDRWQVDGVFYSSEEETELSMDADKIVEAFFNEEPVASVTLSMHEPIGQGAVAPTVGDHKYDAGKSLTLQATPAEGWLFEHWLVEDAVYSSEHEAELTMNTDRNVKAVFVRKTHTLTMLEPSGSGNVEPAVGISIYKEGSVVTLVATPSNGWDFDFWQIDGALFSYNSQITITMNASKTAKAFFVEEPPTVFTLTMVEPIGQGSVSPPVGDHTYIEGTSVPLSATPADGWEFEAWYLDGTFYSDSETTSIIMDRDKSVSAEFVQKAEKVTLEIYKYGRGTVSPPEGTYVYDKGSSVDLSATPDSGYHFEEWLVDGTTYEVPEITITLEWDTIAQAVLRCNCGGSCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W0</accession>
    <name>I2F7W0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ORF">Theba_2395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731755.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2395"/>
    <dbReference type="EnsemblBacteria" id="AFK08013">
        <property type="protein sequence ID" value="AFK08013"/>
        <property type="gene ID" value="Theba_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2395"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_0"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="360" mass="41054" checksum="E719BC0D122FFAE3" modified="2012-07-11" version="1">MDLGKIMEVFRERFKEVEKELSKPEVASDPDKLMEYGKKHAELSEIINLYSEIDSMKGELEEWHEMKATAEENEQEVIANTISDLENRIARKELNLKGLLVPDLADERNIIIEIRAGTGGEEAALFAADLFRMYTRYAERNNWKSEIIDSNETDIGGFKEVIFQIRGRSVFSKLKYESGVHRVQRVPTTESGGRIHTSTATVAVLPEVSETEVKIDPADLRIDTYRSSGAGGQHVNKTDSAVRIVHEPTGIVVAVQKERSQHQNKARALEILRARLYEMYSSKAENEITEARRTQIGTGERSEKIRTYNFPQNRVTDHRINFTSYRLLYVMDGDLDELVTELSAADINKRLELLHKKLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X2</accession>
    <name>I2F7X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MnhB-like protein, subunit of Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731766.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2408"/>
    <dbReference type="EnsemblBacteria" id="AFK08025">
        <property type="protein sequence ID" value="AFK08025"/>
        <property type="gene ID" value="Theba_2408"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2408"/>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069132_3_0_0"/>
    <dbReference type="OrthoDB" id="1836204at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK08025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="223" mass="24106" checksum="0E7D6A9F92BF74E3" modified="2012-07-11" version="1" precursor="true">MKIAGIIALITIFMIVLFSFDPFGSIPEPIEEIVNRVNVPNIVTSVYLETRLYDTIFEIIVFTITALGVASLFTSLPVNSDEGQQVFGTVTVYSGGLAALSITLFLYVVINGHISPGGGFVGGVVLATGVVTYGLTSSFRRASLHYEIFKVNMLENVSLILIFAFSCFIIIFPEAHAQILSEAGFGSVFSGGLIPMMNILIGIKVYAGAWKMSSEFINRRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X6</accession>
    <name>I2F7X6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731769.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2413"/>
    <dbReference type="EnsemblBacteria" id="AFK08029">
        <property type="protein sequence ID" value="AFK08029"/>
        <property type="gene ID" value="Theba_2413"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2413"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_2_1_0"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10444" checksum="F737B001C1E7BD4B" modified="2012-07-11" version="1">MRTVEIIIQGRVQKVGMRNFIRRLATRHGITGYVENLDDGSVRVVAQGSKAQLNAFLAKIEKGSISIKLSGGNIKRVTERPSMEHGFMDFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F801</accession>
    <name>I2F801_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731789.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2441"/>
    <dbReference type="EnsemblBacteria" id="AFK08054">
        <property type="protein sequence ID" value="AFK08054"/>
        <property type="gene ID" value="Theba_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2441"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="321" mass="36520" checksum="84D00C34945749A5" modified="2012-07-11" version="1" precursor="true">MAETLIKIRDLKTYFPVKKSIFSKKLFVRAVDNVNMDVPKGSTFAVVGESGSGKTTLARTVLRLIEPTSGEIEFDGKNILGLKGKDLLEVRRNMQIVFQDPYNSLHPRKLIKNIIGEGMKIHFKISEIEIRDRIASVLKEVGLIDDHMYRYAHEFSGGQRQRIAFARAIVLKPKFIVLDEPTSALDVSVQAMVLKMLKEIKVQENLTYMFITHNLSLVDYIADKVAVMYVGEVVEMGDKATIFNHPAHPYTDLLMASNPIPDPKFVREKRLLKGEIPSSINPPSGCRFHNRCPFADERCAREEPELREIKPGHFVRCHYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F828</accession>
    <name>I2F828_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731813.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2470"/>
    <dbReference type="EnsemblBacteria" id="AFK08081">
        <property type="protein sequence ID" value="AFK08081"/>
        <property type="gene ID" value="Theba_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2470"/>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890827_0_0_0"/>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028894">
        <property type="entry name" value="RDH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13486">
        <property type="entry name" value="Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK08081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="34886" checksum="54364BDE3F83AB14" modified="2012-07-11" version="1">MRRYDERNTIFARMNYEAGTPEYCDYYSRHPELKEIDDELRERPDLCDRNSPSYDPLDASEVSSNFSLVASLRSLCDGKPSSEKLHVDITTATETIKRIAIDSGAELVAITNMKPEFYYSHRGRHRENYGDEISLRLPFGIVFAVELDGEMIDAAPAMPAMVESSRKYLKAAMIGLTISYFIRGLGYSARNHMDGNYLAVLPIVGAAAGLGLIGRHGLLISSSLGPRMKLGLVTTEMPLKCTPPLEKNLERFCSDCGICSRECPVSAIPGCEGQKANDTPRWKVDHELCYSYWRRNGTDCGICIRVCPFSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F858</accession>
    <name>I2F858_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731843.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2503"/>
    <dbReference type="EnsemblBacteria" id="AFK08111">
        <property type="protein sequence ID" value="AFK08111"/>
        <property type="gene ID" value="Theba_2503"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2503"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_0"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="68"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="403" mass="46162" checksum="F3A503FE601C2059" modified="2012-07-11" version="1">MDYDFDTLVNRENQGNMKCMLTPDIVKKMNLISYAGAEMDFKTAPAIIDALVERARNGLLGFTLADEKYLSSVQWWMKNMRNWEIERDWIVPTYGTIHSVATAIRAFTKEGDGVIVQPPVYNRYEQAVRRTNREIVSNPLIYGDGKYSMDFDDLERCMRVEKNRLFLLCNPHNPIAKVWQRSDLEKISSLAQRYNVLVFSDEIFGEITFNGNSAIPYSTVAGDESNSIVATSLGKVFNLTGVNSANIVIPDPSTRKRFRIQRDADHYGSIDPMVHAAVCAGYGPDGADWVREMREYVWENVSIMKDFFTRNIPAVTMTEVEGSFVIWIDWRRLKLDDEELHSFLLNEAYLDLDRGINYGEGGEGFTRMNIAAPRRKIEESLGFLFEAAARRGYAVSETLNRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F896</accession>
    <name>I2F896_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphosugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731874.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2548"/>
    <dbReference type="EnsemblBacteria" id="AFK08149">
        <property type="protein sequence ID" value="AFK08149"/>
        <property type="gene ID" value="Theba_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2548"/>
    <dbReference type="eggNOG" id="COG2222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_3_0_0"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05710">
        <property type="entry name" value="SIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035488">
        <property type="entry name" value="FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="351" mass="39818" checksum="6812551E68A161F0" modified="2012-07-11" version="1">MTIQDFLNNAKQSVLFTAPSLEKDLSAFLEEHTERIKNLAKTALDKGYKQIYWVGSGNSWCNLYSGDYILKKMTDLPSDYYKSYDFIWTNPSRLDKDALVILASFSGNTEDTAAALRFANGKGATTISFTSKPDSILAREADESIVYDSNGLFILPLAGAFIFSLEIARLKGRDVSKLYEQIEIMPELLGRIYKEEESRAYRLARKYQESDLFYVLASGAAYAIGYKFGLTVFMENMRVNASFIETSEFRHGPAEMLDGHKPLMVFLVGSDESRDMSERVIKIAESNGAELIRFDVKDYGDFDPLFAPFLLMIPLQWFAVYSAYYRGIFDLDERVLMGRGKMSTGNQITWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B7</accession>
    <name>I2F8B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731890.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2570"/>
    <dbReference type="EnsemblBacteria" id="AFK08170">
        <property type="protein sequence ID" value="AFK08170"/>
        <property type="gene ID" value="Theba_2570"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2570"/>
    <dbReference type="eggNOG" id="COG1906">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056143_0_0_0"/>
    <dbReference type="OrthoDB" id="801223at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007294">
        <property type="entry name" value="DUF401"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39556">
        <property type="entry name" value="PTHR39556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04165">
        <property type="entry name" value="DUF401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="393" mass="43305" checksum="D12B2E85D3E0DCD9" modified="2012-07-11" version="1" precursor="true">MNTLAVAIAIVVLIVSLKLFKDISLSLLFSVISLGIVLLIPPADYFNAFAKEVSDWEFWKVIITVFSIYLMGETMDKSGNSSRFVRAVESLFPEPRVSIALMPAIIGLLPMPGGAMFSAPMVKDLAKSDPTISNEDGLVFNYWFRHAMEFFWPLYPALVIASGISRIRLNTLVLWLMPIGVVALVTGYLLMIRKPIKIRYSRSALKELLISAWPIIAVIILVILNQPGWLSVLGTSLVYLLLNKNKKKVLLAALKYKTFILLLTVFFYKDLVEIAEVPQSMGSELIAWSIPPLTLVILLPFLMGFMTGVTQAGVGLSLPLILSMGNGYGTLATTILAYTFAVVGVLVSPVHLCLVLTSEYFKVEYPRIIKRISVVTLLSVAAGIVVFVLLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H1</accession>
    <name>I2F8H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731931.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2624"/>
    <dbReference type="EnsemblBacteria" id="AFK08224">
        <property type="protein sequence ID" value="AFK08224"/>
        <property type="gene ID" value="Theba_2624"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2624"/>
    <dbReference type="eggNOG" id="ENOG502ZEGG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2046921_0_0_0"/>
    <dbReference type="OrthoDB" id="2183504at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="120" mass="13752" checksum="2948D0DC2980D1C9" modified="2012-07-11" version="1">MDREEVLKILKLVADGKVSPEQGRDLLEEFFESYEEEKSGRKFSIEVVDNHSGKVEAHIRLPVRLAKFVGNFVKEKDANFKIGDRVVDYNLKEVLEEVIKSGESVEIETGDKRVTIKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P0</accession>
    <name>I2F8P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487325.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2694"/>
    <dbReference type="EnsemblBacteria" id="AFK08293">
        <property type="protein sequence ID" value="AFK08293"/>
        <property type="gene ID" value="Theba_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2694"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_0"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="125" mass="13281" checksum="03DEFFDEE5031B45" modified="2012-07-11" version="1">MLRVINTDKAPAAVGPYSQAVAAGGFLFVSGQIPLNPLTGEMVTDFEEACKQSLDNLFSVVAAGGSSPDNIVKVNVYVRDMGKFSILNEIYATYFKGHKPARAVVEVSNLPKNAPVEIEAVAIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P4</accession>
    <name>I2F8P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731991.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2698"/>
    <dbReference type="EnsemblBacteria" id="AFK08297">
        <property type="protein sequence ID" value="AFK08297"/>
        <property type="gene ID" value="Theba_2698"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2698"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592863_0_0_0"/>
    <dbReference type="OrthoDB" id="345245at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="78"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="461" mass="52570" checksum="43DE3ECDD584CA63" modified="2012-07-11" version="1">MGKFVLGPTFEEMLHPEKIDRKTREIAWKMRKEDPLDPINLYNISWRDIDNRIYYFVLPKEFTGVDANIVVLYGKDFPTGSHKVGATYSILMEKVLRGEVDPTYHTLVWPSTGNYGIGGAWVGCRMKFDSVVILPEEMSAERFNIIKEYGARVFATPGCESNVKEIYDKAKELKAANPEKVRVLNQFDELGNYRFHYYVTGNTILEMMDELGLGNGRVSAVVATVGSAGTIACGDRIKEVYPEVKIVAGEPVQCPTLSLNGYGGHDIQGIGDKHVTWIHNVMNNDAVVALDDIECKKLLQVMTDEEGKKFLKEFLKADDVDTMADIFGISGVANIVGAIKMAKYYKMSNKDNIVTIATDNIDRYHSVMENMSKTYGELTRDEARHRFESYVLGAKTDWIFEGTMDNRLRWHNLKYYTWVEQQGRSVEELNKTMSQDFWKAESGKIEEIDELLLDYRVRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q1</accession>
    <name>I2F8Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731997.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08304">
        <property type="protein sequence ID" value="AFK08304"/>
        <property type="gene ID" value="Theba_2705"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2705"/>
    <dbReference type="HOGENOM" id="CLU_1813533_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="142" mass="15966" checksum="3C78F92AA17DC190" modified="2012-07-11" version="1" precursor="true">MEDYRWIYLAILLQAALLGTVLFFGDTLFHSSVESEFAKEVTAKEIGSSLLSDYLKGFEDRSLPEESRLTGYLIEDIIVFEGTGNYTVLLASISVKPTDIDSCLWNSLGSREGSWIKDIRLSVYLERDQTGRFTIVKTVPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E0HZW6</accession>
    <name>E0HZW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06894">
        <property type="protein sequence ID" value="AFK06894"/>
        <property type="gene ID" value="Theba_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1197"/>
    <dbReference type="HOGENOM" id="CLU_2844790_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="65" mass="7199" checksum="AB4521A36FD82036" modified="2010-11-02" version="1">MIKAGNQNRVLKNKMLNQVQTNLSANSEDGGPVTDNVVLSSVQRVFVLKRTAVLRCEIPYRIITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1F5</accession>
    <name>I2F1F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaA</name>
        <name evidence="13" type="ORF">Theba_0001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487417.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0001"/>
    <dbReference type="EnsemblBacteria" id="AFK05758">
        <property type="protein sequence ID" value="AFK05758"/>
        <property type="gene ID" value="Theba_0001"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0001"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_2_0"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="135"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK05758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="447" mass="50688" checksum="D6DBBDD3AB67BFE7" modified="2012-07-11" version="1">MSNSIISTLKKKVSKKTWDNWFSTFELKAVEDERVVFSVANLFIKDWLQTKYGAVISDSIAEILGRRVSFEIVYKNKETPSVDSTSDQISGSLLKRKPLMISNLNPEYTFSNFVVGSENKALYEVALDVTQNPGKYNPFFVYGGVGLGKTHLLQAIAQETMSNFPDKKVLYITSEQFMNDMIQSIKENNIQKFRDHYRKKSDILLIDDIQFLIGKKGVQNEFFHSFNELHDSGKQLIICSDRNPEELETFHSRLKSRFQMGMLMSIQEPRPSTRFHIAKQLAQRESVSLPDDVAKVLADNIDGNLRRLRGAIIKLIVHSSVFRSQIDLSLATQILQSFTGSINVPAFQRPIDQIYSAIEKTMKVTKKEIESGSRSKDIVLARQLTMYILKNHFGKQVTEIARETGKQHSTVIHSLKKIDKSVMMGKGATKLLYDDVIGIITSNSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G6</accession>
    <name>I2F1G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Triosephosphate isomerase</fullName>
                <shortName evidence="9">TIM</shortName>
                <shortName evidence="9">TPI</shortName>
                <ecNumber evidence="9">5.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">Triose-phosphate isomerase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoglycerate kinase</fullName>
                <ecNumber evidence="8">2.7.2.3</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">pgk</name>
        <name evidence="9" type="synonym">tpiA</name>
        <name evidence="11" type="ORF">Theba_0014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="9"/>
    <dbReference type="EC" id="2.7.2.3" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729952.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0014"/>
    <dbReference type="EnsemblBacteria" id="AFK05769">
        <property type="protein sequence ID" value="AFK05769"/>
        <property type="gene ID" value="Theba_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0014"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_3_0_0"/>
    <dbReference type="OrthoDB" id="90424at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="411"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="636"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="9">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK05769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="655" mass="70563" checksum="4B313A454B45578B" modified="2012-07-11" version="1">MSKTLTLKDIDLAGKRVLVRVDFNVPLDKETGEVSDDTRIVAALPTINEIIERGGKAILVSHLGRPKGKRDPKYSLEKVAERLQSLIGKPVTFVPDCIGEEVEKAVSKMNNGDILLLENVRFYSEEEKNDPDFSRRLSSIADIHVNDAFGTAHRSHASNVGVARYLTSVPGFLMQKEIEMLGMAIENPEHPYVVILGGAKVSDKIGVITNLLEKADRILIGGAMMFTFLKAQGKSVGDSLVEEDKIDLAREILQKAREKNVEFVLPVDTVIAKEIAAGSESKVVDLEEGVPAGWKGLDIGPSTIELFNKKLSDAKTVVWNGPMGVFEIDDFAKGTESIARTLASLNDAVTIIGGGDSAAAINKFGLAEKVSHVSTGGGASLEMLEGKEMPGIKSLSIEGGKKKRRLMVAGNWKMNKSPNEARMFAGFLASSIGNENAVDVVVFPTSLSVAGVADILKDTSIKFGVQNIYPADSGAFTGEISASMLSDLAVEYVLVGHSERRHIFGETCELTGEKIKSVLKHGLTPIFCVGETLEEREAGRMKEVLETQIRKGFSGLGKSDLERIIIAYEPVWAIGTGVVASPEQADEAMKFIRDLIASLYGVDLSESVRILYGGSIKPENFESLISMENIDGGLVGGASLQESFVQLVAIAESHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H4</accession>
    <name>I2F1H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="9" type="ORF">Theba_0022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729957.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0022"/>
    <dbReference type="EnsemblBacteria" id="AFK05777">
        <property type="protein sequence ID" value="AFK05777"/>
        <property type="gene ID" value="Theba_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0022"/>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_0"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="171"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="501" mass="58642" checksum="5BDD46BFCBC21549" modified="2012-07-11" version="1">MSEETRRQRIEEINQMRQEGIEPYPYSFDKTHWAAQIKSEFAYLQNSETKEDTVLSTAGRVVAVRNHGKSSFFVLRDNSDRIQAYIRLDGVGAESFEVFKKYVNIGDFVGVKGFPFKTHTGEISVFVKEFEILSKSIRMMPEKWHGVKDKEIIYRQRYVEMLSSDDALKRFKIRSELFRLVREFLQSKNFVEVDTPMLHYLTGGASARPFKTHINVFESDMYLRIAEELFLKRYLVGGFERIFEIGKNFRNEGVSYKHHPEFTMMELYWAYADYNDIMNITEEMINFVVREIAGSEIISYQGKEIDFSRPWRRVKMADFIKENLGVDILEDSDDRMMAVLKKHNTEPEIKERGHLIEKLWDLVEHNLVNPTFVTEHPVIISPLSKVHREDSRVTERFELIISSMEMANAFSELNDPIEQYNRFLHQAGLRDIGDEEAQMMDHDFIRALEYGMPPTGGLGVGWDRIIMLVTDSPSIRDIIPFPLVRPISFEEEEALEISDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H8</accession>
    <name>I2F1H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729961.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0027"/>
    <dbReference type="EnsemblBacteria" id="AFK05781">
        <property type="protein sequence ID" value="AFK05781"/>
        <property type="gene ID" value="Theba_0027"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0027"/>
    <dbReference type="eggNOG" id="ENOG5033QX0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417861_0_0_0"/>
    <dbReference type="OrthoDB" id="1465990at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="656" mass="72408" checksum="169762F87DE0E7AC" modified="2012-07-11" version="1" precursor="true">MIKICYSSLDGRVKEIKRIAWRVLIFAMLLMLISCSNSTNYAVSIKQIDCEGSTCNLRLEISEDGLSLPEFLITLDRPPVDGSDGIRIKGTEISLDLKEAGSHTIFVTLVDGKRFLSTPVSKEVIINLNPPDAPDLTWSLSQGELKLSLRSDSSDSVTDYRILVNNVLHSSTQGTFSFPVDRDAHYVIQAFSVAGNLRSDPSILDLKLSEDFAPEVELTSVLPFTNGAVDITVVDDWDRTNDLSIKAFLEESNILLLFDGNRLIPEIPLPEGINTLVVRVADSSGNVTELKRELKTVRKTSVEIPELYIEEGTIRNARWTTPKGMVELQRYIDGEWITLSTHSSEEESSIIAKDSISEKGDLYRIVVDSDNEKLLPSVPVFAKESLFRRFSTEFISSFLGMDALLVGGNSYRFYGNIVVRENTVMRVESGTSLTIPRGNTLLVSGVLDLEGWKDRIKVNPGGSSGTIEVTNNGVLIARSVDFNNSTVSIENAAVAVFEDCTLSGDLKISGARTVQIYNSQFSGDMEIENVRELLVHQSDFSGSSLVLSGLGRVLLSRSSLRFHSLEIVDSRLEAYESLFEAEGLFVRKTSHLLQTRGALIETEISVSGASSIHIEEPNLTGDVKIELRDLSRLSLQKDFEGSIEIVSDEKSAIKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J6</accession>
    <name>I2F1J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729974.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0047"/>
    <dbReference type="EnsemblBacteria" id="AFK05799">
        <property type="protein sequence ID" value="AFK05799"/>
        <property type="gene ID" value="Theba_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0047"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_0"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="113"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="228"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="461" mass="49742" checksum="9F673D3F94313B43" modified="2012-07-11" version="1">MHSDEAYSAVINKILSGGADFAEIFLEERYTGSINMVQGEVEGSVSGKLFGAGLRAFKGTRSIYAYTNELSLDGLTKVAERLRAVISQDRVADSVIDFRNEEFVDVCPVLFSPNNVPKKEKVRVMQLAHEGASTFASTISQVVVNFVEYDQNVWIYNSEGVKAHDRRVRTRLAISAVATKDGQMESGFYGPGAAMGFEFFNMVDPRAAGERAARIADRMVRAEFVPAGRMPVIISNEFGGVIFHEACGHALEATGVAKGASVFAGKLGQKIANECVSAVDDPTIPNAWGSANVDDEGTPTRRNLLIDKGVLKSYMIDRLGGIKMKMKPTGSARRQDYTFAPTSRMSNTFLLPGEYYPEEIIAATDYGLYAKSLGGGSVMPSTGEFNFAVKEGYMIEKGRITRAVRGATLIGKGNEVLTKIDMVGNDLERGQGMCGSISGSIPADVGQPTVRVSELIVGGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K7</accession>
    <name>I2F1K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp enzyme, D-alanine-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729984.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0059"/>
    <dbReference type="EnsemblBacteria" id="AFK05810">
        <property type="protein sequence ID" value="AFK05810"/>
        <property type="gene ID" value="Theba_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0059"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_2_0_0"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="96"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="315" mass="35659" checksum="23F12BDF7D979F43" modified="2012-07-11" version="1">MRITVVHDTPLNLHHQEMVNSVVSSLEKIFEVDSRPFEIDAVGRLRGTDLVFNLTTAMGNTERQVHLPAVLDLLGIPFTGSGTTANALCINKTLTKLIMKAYGISTPEFFSVRPGETADNLPFSPAIVKPVKEGGAKGIWEDSVVESVDDMQRAVSRIHERFQQPALVERFIEGREFTVGIVGNEVLPIMEIDFSSLPDHLETFYSYRVKQFHGDETNYICPAKISRREETVIREFSMRVFQVLDLKDYCRIDLKIDDEGKIYFLEVNSLPLLVPDYSDIVKMAETRGWSYEDLINRIVASAIRRYGIGKENGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M4</accession>
    <name>I2F1M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-polyprenylphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730000.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0076"/>
    <dbReference type="EnsemblBacteria" id="AFK05827">
        <property type="protein sequence ID" value="AFK05827"/>
        <property type="gene ID" value="Theba_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0076"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_0_0"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="277" mass="30428" checksum="34D2739C57AA678F" modified="2012-07-11" version="1">MYAVLSKKRIAPDTYDIWLSHPDIYRYAKPGQFLIIRIDEFGERIPLTIASAEKDRVRVIVKAVGKSTYKLCAMNEGESVSDIVGPLGNPSEIEKLGTVCVVGGGVGIAPLFPVARALKAAGNEVIGILGAANKDHLIMVDEFRPFLDRLYLSTDDGSAGIKGTVTNPLKEVIADYSPVTIWAIGPMVMMKFVSLLASQNDIPCWVSLNPIMVDGTGMCGACRAEVGGEMKFACVHGPEFDGRLVNWDELIKRQYQYREEERVALEKYVRELGEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R1</accession>
    <name>I2F1R1_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730030.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0115"/>
    <dbReference type="EnsemblBacteria" id="AFK05864">
        <property type="protein sequence ID" value="AFK05864"/>
        <property type="gene ID" value="Theba_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0115"/>
    <dbReference type="HOGENOM" id="CLU_2193817_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657732" evidence="2">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="108" mass="11256" checksum="03DD25063F9571D8" modified="2012-07-11" version="1" precursor="true">MRKVLLILLFVSMIFGLTLANNGKGPGDGIPDGQEPGAGFGSPGTGKGEGPGAGKVDSGGSTTLLLENLEAETASSEPVLVRSMNRLVEMIRNMLRNLFRVRTALSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R7</accession>
    <name>I2F1R7_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05870">
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        <property type="gene ID" value="Theba_0122"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_185992_0_0_0"/>
    <dbReference type="OrthoDB" id="2075077at2"/>
    <dbReference type="Proteomes" id="UP000002881">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="65" mass="7715" checksum="BC46E06C2CD615F8" modified="2012-07-11" version="1">MDTRQFLRKEIEAVPDALLEEILRFVKALKERNLPALSRELLDASESAFARDWLREEEDKAWKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T1</accession>
    <name>I2F1T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0138"/>
    <dbReference type="REBASE" id="48543">
        <property type="entry name" value="Mpr42ORF138P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05884">
        <property type="protein sequence ID" value="AFK05884"/>
        <property type="gene ID" value="Theba_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0138"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009503_0_0_0"/>
    <dbReference type="OrthoDB" id="45009at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="300"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Type_ISP_C" evidence="2">
        <location>
            <begin position="673"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1028" mass="118233" checksum="2DAD208D2F364E44" modified="2012-07-11" version="1">MFEAYLKGIFEKFRHGDAREESYYSVLERLLNDYAAEKNIKASVTTLPKQTEAGNPDFRIWDGKQNIIGYIEAKEPSVNLDSVENSEQLKRYRSTFHCLILTNFFEFRLFIDGEKRMSSLFAYSNIMFSMNRVPPVQDESGILRLLEGFFESSTPRVLNAKSLATELAKRTRFLRDEIIRVELESENADSEDLEGFYEAFKDYLISDLTIEGFADLYSQTITYGLFAARTRATNGFNRQLAYTYIPKSIGILSDVFQYISMGKISRSMEWMVDDISAILATADVRGILDRFYHEGKGSDPIIHFYETFLAEYDPSTREKRGVYYTPEPVVSYIVRSLNIILKEKFGKADGFASEGVTVLDPAAGTMTFLAQAAKLAVEEYSQKYGEGMVPGLIRDHILKDFYAFELMMAPYAIGHMKMSFFLEELGYRMEDDERFKLYLTNALDMEEHGQAKYVGTTSLAQESELAGQVKKEEDILVILGNPPYSGHSSNKGNWISEEIKRYFFSDGKPLGERNPKWLQDDYVKFIRFAQWKIESAKKGIVGIVTNHSYLENATFRGMRKSLMKTFDEIFILDLHGNSRKKERASDGSEDQNVFDIQQGVAIAFFIKNSDAITSTVKHEDLWGRRQTKYDWLEGNMILSTEWKQLSPSSPKYFFVPVDEEKLRRYNDWTRISEIFPTSSVGIVTARDKLTIHFTPNEVWNTVNLFIKLSPENARTAFELGKDALDWKVEYARRDLVESGPDKSKVVPILYRPFDVRFTYYTGRSRGFICRPRSGVMANMLGENLAIITCRVNRQMSNNYFFVTDKITDFHVLDSAGDSTSVFPLWIGTSPETGPLFAQDIEEGSRPNLSNKLSGLLCRDLNPIDVARYIYSIFNSNTYRKTNAPFLKSDFPRIPLTSYRELFEEIASYGSRLIDLHLMRSPDLENLVARFPVAGSNEVEKLSYEEKNTRIYINKDQYFEGIPLQVWKFMIGGYQVCKKWLKDRKGRPLSNAEILHYLKVVTAISKTIEIQSEIDEIYPLIEQNSVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W7</accession>
    <name>I2F1W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS116/IS110/IS902 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730084.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0180"/>
    <dbReference type="EnsemblBacteria" id="AFK05920">
        <property type="protein sequence ID" value="AFK05920"/>
        <property type="gene ID" value="Theba_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0180"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674068_0_0_0"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="408" mass="46857" checksum="38E2D5102A4E5EC4" modified="2012-07-11" version="1">MEIVGIDWGRKKHYCYLLHQGKKLVLKNKEEDFAKLLKIKEAVYVIEDGNNRIVDYLLRNNRQVYILPSRRSSEARSFFVIEGKSDFIDSKVIAMTYEHNPEWCLQVKREGIAFELDVLVEENAVINVSMMQDIGRLDAYLERYWPEVKEVFSGTSARKLAFISICPTAKDFLTMSDKEILQKLKEMGFLINSNLKSKLKELRKIALERYVPASIRTLIVAFSRYAMEKKVMKEEIGKQMKEIIEESEFSVLLTLPGVGAIIASQLIVAYLTHKFSSYRDLQRYAGTTPTYYGSGNKNTTKMRSNCNHYLRGTLHIASLAATNSSKWMKRFYDNKKSEGKSSAHALRALANTILKIAFAMLRDLTPYSEEKFFKRNPLSDYTPSKKEGEQKPEYSLKVSSVATCRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y2</accession>
    <name>I2F1Y2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">Theba_0200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491437.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0200"/>
    <dbReference type="EnsemblBacteria" id="AFK05935">
        <property type="protein sequence ID" value="AFK05935"/>
        <property type="gene ID" value="Theba_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0200"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_0"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="86" mass="10228" checksum="0DBD3650AB9DF933" modified="2012-07-11" version="1">MEVNKQELVKEYQIHDNDSGSTEVQIAILTARIRHLTEHLKKHPKDFHTRRGLLKLVGRRRKMLRYIKTKKPEVYLELINKLGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F200</accession>
    <name>I2F200_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">Theba_0219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730115.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0219"/>
    <dbReference type="EnsemblBacteria" id="AFK05953">
        <property type="protein sequence ID" value="AFK05953"/>
        <property type="gene ID" value="Theba_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0219"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_0"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="138"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="372"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK05953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="434" mass="48909" checksum="74C0518963684D9E" modified="2012-07-11" version="1">MKVAFRTFGCQMNINDTEAMMGVLSKAGHEIAVSEEEADAVIVNTCAVRAKSEDKLYGKLGQLKAVKKRKGRLLVGVCGCVAEKNALELLTHKEVDFVFGTRAITRVDELLGRAESGERFIEMGDFIDELDSTTPRIRTSAHHAWITIIFGCNKFCSYCIVPYTRGREKSRNMDDILSEARELAVNGYREITYLGQNVDSYGKDLEDGSSLAKLIRETIEINGIERIWFLTSYPRDFSDELIDVIASSEKVSRAIHLPVQSGSNRILKDMNRGYTREYYLDLLGRVKNRIQGATLSTDLIIGFPGETEKEYEETVSLVKEVRFERVNLAMYSPREGTLSAKKMKDDVPQEVKTRRLNDLLAIQKHINREENEKYLNETIDVIGEGKVKGNGKIYGRTMNNKIVIYEAEADLIGQPVKIRIVRVSAGPLYGVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F222</accession>
    <name>I2F222_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730136.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0241"/>
    <dbReference type="EnsemblBacteria" id="AFK05975">
        <property type="protein sequence ID" value="AFK05975"/>
        <property type="gene ID" value="Theba_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0241"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_4_1_0"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="258" mass="28367" checksum="69C59F1E131D5B2E" modified="2012-07-11" version="1" precursor="true">MISISMLSSSRKRTLAPIVSVGFLLLGWFIASAIVSSDLLLPGPLETMEEFLRIISSRKGWSDIAETCAKAFLGLFIALGLGLAVGFVMGLIDVLYELIKPIVVILQSIPIVSWLALAIFWWGVGFSSPVYIVFLTLFPIFTINIAEGVRNVDKKLVEMAKIYKIPRNTVFGKIYLASAFPFIVSSMRAGIGIMWKSVAVAEFMVGASGIGRAMSDAKYSINIERVFAYTLVLVVLGILTERLLDMIIKRGSRYALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F257</accession>
    <name>I2F257_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ORF">Theba_0278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0278"/>
    <dbReference type="EnsemblBacteria" id="AFK06010">
        <property type="protein sequence ID" value="AFK06010"/>
        <property type="gene ID" value="Theba_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0278"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_0"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="38176" checksum="0FA2683B402732EC" modified="2012-07-11" version="1">MSHFKSLTLEWSEDRLKMIDQRKLPTAEEYVECRNHEEVYVAIREMIVRGAPAIGATAAFGYLLGAKEVLDASDEVLLDHMTTVKKRLSESRPTAVNLFWALDRMENALNSNWGLERKKLIESLERAALSIAKEDIEINKSLGRNGATVVRDGDGILTHCNAGALATVDYGTALGVMRAAVEQGKRIKIFADETRPYLQGARLTAWELIKSGIDVTLICDNMAGWVMKKGFIDLVLVGADRIAANGDAANKIGTYSVAILAQRHGIPFYIAAPLSTVDLTTASGEEIPIEERSHREITHIGNQQIAPEGVRCLNPAFDVTPSSLITGIITEKGIARPPYDVSLRGMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F270</accession>
    <name>I2F270_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase FolE2</fullName>
            <ecNumber evidence="2">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folE2</name>
        <name evidence="3" type="ORF">Theba_0292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts GTP to 7,8-dihydroneopterin triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491763.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0292"/>
    <dbReference type="EnsemblBacteria" id="AFK06023">
        <property type="protein sequence ID" value="AFK06023"/>
        <property type="gene ID" value="Theba_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0292"/>
    <dbReference type="eggNOG" id="COG1469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062816_1_1_0"/>
    <dbReference type="OrthoDB" id="757842at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_B">
        <property type="entry name" value="GTP_cyclohydrol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022838">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="May be catalytically important" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="256" mass="29711" checksum="1EB1F3D24CA4FBCD" modified="2012-07-11" version="1">MILRDVQNEKDKRNIKINMVGIKSIEYPIVVLDRKFGTQNTVGKFDLFVDLPKDFRGTHMSRFVEVLERHHKKITPRSMESILNDMRDSLKADVAHIKVEFPYFIRKKAPISGSESFSSFKCSFIAMKDGTFDFVLGVKVPVMTVCPCSKEISDRGAHNQRAEVFVSVRMNSLVWIEEIIEYVEKSASAPIFSLLKREDEKFITEHSFDNPRFVEDLSREVVLLLQDDSRINWYRVEAISQESIHNHEAYACIEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F277</accession>
    <name>I2F277_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491770.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0299"/>
    <dbReference type="EnsemblBacteria" id="AFK06030">
        <property type="protein sequence ID" value="AFK06030"/>
        <property type="gene ID" value="Theba_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0299"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_1_0_0"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="35616" checksum="A240D020AB62779F" modified="2012-07-11" version="1" precursor="true">MNFLRGLNAPFNLSGVISIEKEFKVTKENFYERLDRVLRKELSDLKLSSIYKLLRRGNVRVNGNKIRDGSWKMEIGDKVQVVFSGDPSKLKRLEESRELTPKHIPLDILFEDDLIVAVDKPSGISVHPGKGIQIITLVEGLMAYGNSKGFVPRPVHRLDKHTSGVILFAKSPEAARELSKLFRERGVEKGYFTLVKGFPEKRGKLVSQREKFVESLAFTVEKSYATTSLLWIDLFTGKKHQIRRQLSEAGYPVVGDDVYGDRLFNRDFKKETGLRRYFLHCSRLSFARNDGKEIEIISELPGDLKRVLGCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F278</accession>
    <name>I2F278_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491771.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0300"/>
    <dbReference type="EnsemblBacteria" id="AFK06031">
        <property type="protein sequence ID" value="AFK06031"/>
        <property type="gene ID" value="Theba_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0300"/>
    <dbReference type="eggNOG" id="ENOG5034C3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085051_0_0_0"/>
    <dbReference type="OrthoDB" id="2026735at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="256" mass="29980" checksum="D6765D261E5E48EB" modified="2012-07-11" version="1" precursor="true">MPRIRFVFLIIVVVFSSLAVAGQAEIRSEIEEANAELSEIYGFSVKYSLTILKGEGHEQPAAIDNNGIYQIFLYTSSYKPGVARHELAHVYFFEYLRIRDINPDEIPLWYHEVIAEGFQNLHTGTRRSALRVAFFDFTEYEEKYPVKDDQSVFYGAVASFADYILKRNSYNKLLEVVNEFSTEREIDTAFLNVFGSTVRSMLLKWRIVFLLPYSPFVVGVVLFLYLLIGRRDKYWRKFPLDLRSLEEDEETKNRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D0</accession>
    <name>I2F2D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name evidence="2" type="ORF">Theba_0354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491932.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0354"/>
    <dbReference type="EnsemblBacteria" id="AFK06083">
        <property type="protein sequence ID" value="AFK06083"/>
        <property type="gene ID" value="Theba_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0354"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100552_2_0_0"/>
    <dbReference type="OrthoDB" id="1783583at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="17812" checksum="D50DC6B02FA24314" modified="2012-07-11" version="1">MNIRIVGTGKPKSNFIVEGVEQYRKWLGAFGRVDLEYFPLGGTTAREREQVKEREGRRYLKAADSQDKILLLDAQGEQYSSQEFARMLEKWQNIGVSNLSFFVGGPLGFSNEVLSKGWQKLSLSRMTFTHEMAVLILLEQLFRAFAILGNRPYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G2</accession>
    <name>I2F2G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0387"/>
    <dbReference type="EnsemblBacteria" id="AFK06115">
        <property type="protein sequence ID" value="AFK06115"/>
        <property type="gene ID" value="Theba_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0387"/>
    <dbReference type="HOGENOM" id="CLU_1174311_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="236" mass="26387" checksum="173F2C490F28E418" modified="2012-07-11" version="1" precursor="true">MSLIKPKRRRGPKLLWLILVIVLVVVAGAGYVYFIVNGVNSSDEMKAEYVDYLFYWQSADNPLYYYVRTTTVGRTSLVIFPIFATIQNSKEVLDPQLGADAVEAVQSWLGTSGDFSYFVNFTPDLIDALSSKLGVNASNPVELIDAMALRGFKLFDYWKINDFVQTVKEYDVASILTSEGIAVLLRRLGNSSRMTYKLETLTEFPMKISVGVGGETVSRMYLKPDSLETVKKALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G3</accession>
    <name>I2F2G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional attenuator, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730236.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0388"/>
    <dbReference type="EnsemblBacteria" id="AFK06116">
        <property type="protein sequence ID" value="AFK06116"/>
        <property type="gene ID" value="Theba_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0388"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_5_2_0"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="62"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="400" mass="45071" checksum="37DE8B192B51FC3E" modified="2012-07-11" version="1" precursor="true">MKSVHQFLVALTVLQVFLFFFLIFLIFRDAFYSFSAKDLAAESFLVVGVDSGGNSSDAVGGRTDYISIVYFRNSGGLVLKSIPRDTVVTYRSEKRKINSLYNSFGIEALIEEVEKLTGRTITGSVVVDFNTVTEITTFTGPIRVEVTTPMHHDDFQQGLHIHFEPGIYFLEGEDLLKFLRYRSSDSGDLGRIDRQKRVLEQLIRNLVSAGPSKMIEMIDFVLEKTDISIDKKTLTDFAVAFFTGKRSVSFTQIDYYIDDEGQIVPTGPGSDEPKAVEIESKSPKILVINNIPDYEERFGDFAETIKSQWLAQAGVKVDATGFVPNISGIEKRDTYLFINSKDSEIRELFSKAHVYHRPFVMLTSSFGGLDYYYALIDSLSKNRFYPAKYDAYVLLGVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I9</accession>
    <name>I2F2I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxynucleoside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492014.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0414"/>
    <dbReference type="EnsemblBacteria" id="AFK06142">
        <property type="protein sequence ID" value="AFK06142"/>
        <property type="gene ID" value="Theba_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0414"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_0_0"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="3">
        <location>
            <begin position="11"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="205" mass="23858" checksum="4141D5CC91D94C3E" modified="2012-07-11" version="1">MMFSKASGKYISVEGVIGVGKTTLVKLLSQKYTMPVVLEVVEENPFLAHFYEDIERWAFQTQLFFLISRFDQQSNVKKAASQGQGVISDYAFMKDHLFASLTLKGEQLKLYEKIFSVLKDQVLYPDLIIYLYADIDTLMKRIALRDRPFERRMDRTYIAMLSDTYEKYMAAFSESRVLRIDTSSIDFVRNVDDLNMVFSRIEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M0</accession>
    <name>I2F2M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730288.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0446"/>
    <dbReference type="EnsemblBacteria" id="AFK06173">
        <property type="protein sequence ID" value="AFK06173"/>
        <property type="gene ID" value="Theba_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0446"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249437_0_0_0"/>
    <dbReference type="OrthoDB" id="627094at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="635"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1485" mass="166130" checksum="97B0B5C5FEA72DB8" modified="2012-07-11" version="1" precursor="true">MHYYRGSSIVPIIITLLLVIVAAVVAAFFLWPVPEPKILISNVSPIPKNAERIQYAEKVELRWEAVYERPRHGLLAEVFAGKDRNSLTRLALDLQGDLTSPTEGIFSFSHEFEVDPHSQYWWKVRVYTEGGKSAESEIWTFVLMNTYPRRPEVVPPGSNLGNVPLKDLTLNWSSNDPDGDELVYDVYFGREPRLDEKDILIRGTNETMVDVSLLKRLDYSTKYYWKVVAKDSYGGESTSYTESFTTQMRVDLPAVTPENPRSGASDFDAGRGFLSWKTSLPLEYYLDELDFDVYLSEGQSRYSLIGTTNSTEIAVPSLKGHTTYSWYVVVRDASGKEKKSEEWIFRTSNRAPIIEMEYPNISPGQDSVPVKWEVVDPDGDSVTSEVFFGPDGDEPARIASGRMTSIFLSALDEETNYTLSIRASDGQGGETIRDISITPGNRPPSIYLSRPVSTEFVEPSVVSFNWFGEDPDGDSLNYMLHLKSKNDSRILGPIESQEYIVRDLEENENYSWFITVEDSRGAFARSEDAVFTTGQKALEVAVPLTPQPGEVEVSLSDTTFSWEIDDESEDLSYRFVLGNDDRLNDIIFENETKETSIELTLDLFSNRKYFWRVDVIKNGSETEGEVWSFTSENLPPALPELRFPVDGASEVSTNDLTLSWVSSDPDGEIVSTKVHLRDSAGNEEEYEALGNSLTIEELDPGHRYEWAVKVTDDGGKSSVSKYASFVTGNQRPVITLTHPPRMFLEGATTPLVVEWELDDPEGEDLEVGVYVNLAEESLGRPVAIGDNLERYVITNLISGRDYLLTIVAEDPGGEIGTLEIPIKSHVSGLDYIYPSGGVFENGREFSWSYSQQNSGYVFRLYDSDHNPIVRRVIQDNTYRPELSFEDGRQYFWAVSVLRDNVEYAGEPVSFISGQSFGVLLEAPRNGEKVPASGVTLKWVLDGDTEAIRQKEVYFGELGSLSRYTVSSNSYQTGRLLAGRTYEWFVQLTDNSGATIRSETFRFSVENRPPELSLISPVNGRAVGETYVDLTWSGYDPDGDHLRYSVYFGTDEDLELYRDSMQSNQIRISGLLMNKTYSWYITASDGQNVVKSETRTFNVTASEFKIDILSPVVDSEVDLTPVFSWQSSEVGSGEFRVFIGESESEMSLIGITDATSMRLQNRLDNGKTYYWSVELWQEGKMISSTGPNRFKTMSSDKPTASESADMLAFYFNDVLNIVSLSSAGLEIVEIPYQYDGKNSAILNGDLLYVIDKSGKLSTINYRTGEAEVIDTLVTNTVPEKLIMEGGYLWILDTKSAGMVIRVVLSESGIPERMETVYRDWTTPVDLFVTQDLSRIYLADALSGIKILERGGETYNDRSSSFEVPLDGYSRAVAESNGVVYSGEAGIDGGLKVIDIARSRKANVGRYYIVLEIEVSGSVLYASTDKGVSIVDISTPDSPVILRDLELTQVDEISVEGSLLIVRSGNSMLVYDVEKPNDPVLLESRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N0</accession>
    <name>I2F2N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="6" type="ORF">Theba_0457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730297.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0457"/>
    <dbReference type="EnsemblBacteria" id="AFK06183">
        <property type="protein sequence ID" value="AFK06183"/>
        <property type="gene ID" value="Theba_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0457"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_0"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="515"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="667"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1174" mass="135565" checksum="6B26025686BD5518" modified="2012-07-11" version="1">MLRLNSVYIKGFKSFAMPTRFEVSSGMTAVVGPNGSGKSNVVDAIRWIFGEQSMKNIRADSREDVIFNGSERFPPSNSAEVKLVFESEEGIFSIAREISRDGQSSYKVNDKQSRLKDIKELFQGTGVGMDIYSIVGQGQVDKVVTASPYELRALIEEAAGTAVYKERKKEALGKLAATEENLSRLEDIIFELGKQRKSLYLKAKRAEKFVEYSAKQKELKNLFFGNIARLEEEKLGTLNGDLGEVRNELKDLQKKLIEGESKWSALRAEFSEVDKEIEGFTKLLEEYKKRQNDLLELKEMYSRRLNEKENRLIEISTRIDNFRSEIEDLDKRKDEIKLIIESLEQQVSDEETALSLSEEERDSLLKNYSAREREWLKHQETFESISKRLSKIENELERLENSREDTSKRLRLIENQLETKRDRFETLKEETESLAKQGKESSDKQRKVEAEVSASKERLVELDAELEKARDRLSSNESEFRRSQMERGLLQRQQEEYQGFSKAVREVFSRKESFAGLRDVVANIIQVPESFETAITVLLGYRMQDIVVDDSITAKRIIEFLKSYKIGRVTLLPIDMIEGSFRNFSRVESHPGFINYAARLVEIPDGFEKLPVYLFGNSIVARTLDDAIEMRRSEGFIGRIVSVDGQLLSSGGSITGGFIGEETRTDLLSRKRRIQELVEREDELEKQIQLGNKQIERLRDEMTEVRGYLKALQEELNELASKGAAINRMIAELLKSAQEVEEEIAELQKLENEYTRRMEENFRKKEVLVGEQSALKEERSELQRKVEEESEELKKQKKALEQLQEKIVDTRLRLSTLYEKQEQYTKEHSSLIQKSKADQENIDLLSREVSEVESETERLRRQVADQERELTSVKKETENLFSSIRNQREGKEQRFSALQEAEEEINEMKAEREKLRDKSHKLEMHIQESEMKLSRVREELDEVEEEVEILSEEKLQDIKVELDDYENKLKFLGSVDLEAIDEYGVVDREYQELDEQRKDLEEAKVKLIELIDKTDAKAKNIFMETFNSVNENFNRYIEEIFDGGEGEIKIIPGEDLLETGLEITVRRPGRKIQKLQLLSGGEKALVGIALVFSLLSIKPSPFYVLDEVDAPLDDFNAERFRVLLRKHAADTQFLVVTHNKLVMEVANVLHGVTMTDGLSRVIPVELQSVETVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S0</accession>
    <name>I2F2S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730330.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0497"/>
    <dbReference type="EnsemblBacteria" id="AFK06223">
        <property type="protein sequence ID" value="AFK06223"/>
        <property type="gene ID" value="Theba_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0497"/>
    <dbReference type="HOGENOM" id="CLU_404811_0_0_0"/>
    <dbReference type="OrthoDB" id="819674at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="679" mass="78181" checksum="163CD961C4EEDD4D" modified="2012-07-11" version="1">MSDSRQREFISFLSAEDVIEKANESLEGKNWKPLAETSNAALISLKTPLVASFFKKFFETKYAFIYRSVEDELISSSSEKLSDLVDTLFQAATERQTLDDSFFVFLDYFKEAPQILEKIVLHYSSLIADKSDSLLTSLRELKNLHERVRRRADQFGLNLALNEIVSRLFSLECPLLPMLESDLVDFLSKFPPDEEGASKFLDNQIGLAVGEYDESSVEVQLSRLETIIKEIKRYSLTFMKWLTVPDNLFVSYLEKGFRRYGTIATWLEGIKEARTEYGLGQSHWEQARRWYFEKISSRILPSFQKAMAGWACWTIIEERQIKDPLAHAGETMRYSARRSEFRIIKCEESSGVFDLCSVDELMITSSGLKKGERSFPFNSIRTQLEELRLSREAFLDSKDAIFVGYTWKYLLPGGGPDKEAKNNERIECFNYYCVTVSATGFGVPLIKLFFAREESARTFIEFLKEARIMSSWKEYPQNGLPAPLKAKTKNRSESEDQINPGEANHKTVGELIIRNMVEESDESEIEETKEVSAVPISAELLEKINSLHYELEWSTKRMNEVEWTYFFPEREKKEEEIKTENPVQEEITGFRELEVKIEALSGKTKRTVCKILSCEPEREYSLQELGLTFWSVFVVAPKVTSGGKPLIEVISGDVPRLVWGNNFDEETRELLKARFASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T5</accession>
    <name>I2F2T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730345.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0515"/>
    <dbReference type="EnsemblBacteria" id="AFK06238">
        <property type="protein sequence ID" value="AFK06238"/>
        <property type="gene ID" value="Theba_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0515"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_0"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="346" mass="37916" checksum="ED15C7E5850F3F9C" modified="2012-07-11" version="1">MKLKRLKELCELPGISGFEERVSSYIMEVVKEKVDSVWTDTVGNLIAVRKGNGKSSKRLMLLAHTDEVGLMVKKINEDGTLSFTNIGGVDPRVLIGKKVLVGENLTPGVIGFEAIHTQDPSSLLKTPNMNKLKIYLGYSRKEEASEKHRIGDPVSFDTPYKEIGDYAVAKSFDDRTGCEVLMRVLESLDEKAVDFDVYFAWVVQEEVGLRGSGVAAKQIKPDVALVFENTTAGDNPELPEYRWATSLGKGPVLTFAHSGLVLDKKILDTIVETAKNNSIEFQYKSRIAGGTDAARLAKVMAGVPSGVISTPSRYIHSPTSVINVNDFLKVVELATILVKEGKVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z7</accession>
    <name>I2F2Z7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0581"/>
    <dbReference type="EnsemblBacteria" id="AFK06300">
        <property type="protein sequence ID" value="AFK06300"/>
        <property type="gene ID" value="Theba_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0581"/>
    <dbReference type="eggNOG" id="COG2078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="171" mass="19053" checksum="03F9DD2277A37AC2" modified="2012-07-11" version="1">MYYSEPVRIARCAMEEFIRHGVLIGTPDWVSEEFLSKRAGCFVSLHTSNGSLRGCIGTIYPLQENVALEIIQNAISASTKDPRFPPVEASELADIDVSVDILSPPERTTLSGLDPKKYGVIVSLGYRKGVLLPDLEGVDTIQKQLSIALRKAGIRESEDYSIFRFSVERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F317</accession>
    <name>I2F317_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP:corrinoid adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492245.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0601"/>
    <dbReference type="EnsemblBacteria" id="AFK06320">
        <property type="protein sequence ID" value="AFK06320"/>
        <property type="gene ID" value="Theba_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0601"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_2_0_0"/>
    <dbReference type="OrthoDB" id="1690483at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="213" mass="24304" checksum="20E32134D09F4C77" modified="2012-07-11" version="1">MINVRSYHIVAALFQLGNSSRMKNIHILSMKYNRILKLKEAEMNTGFVQIYTGNGKGKTTAAIGLAVRAALAGERVFIGQFIKGMRYSELSLPNYIENIVIEQFGRECFIIRDPETKDLEVARKGLARSREVISSREFGVVILDEIFIAFHYRLVSSMDIRRLMLSKPKEVELVLTGRNAPAEIIREADLVTEMREIKHYYSKGVLAREGIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A5</accession>
    <name>I2F3A5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">Theba_0691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492358.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0691"/>
    <dbReference type="EnsemblBacteria" id="AFK06408">
        <property type="protein sequence ID" value="AFK06408"/>
        <property type="gene ID" value="Theba_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0691"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_0"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="134" mass="14932" checksum="68DD158E68A7AF45" modified="2012-07-11" version="1">MWSDPIADMLTRIRNANAAFKESVDIPASNLKKKLLDILKAEGYIDDYKYIEDGKQGVLKVFLKYKGDRRHKVNVISGIVRISKPGKRLYVNKDKLPKVKSGMGIAIVSTSSGVMTDKQARSQGVGGEVICYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B1</accession>
    <name>I2F3B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">Theba_0697</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730475.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0697"/>
    <dbReference type="EnsemblBacteria" id="AFK06414">
        <property type="protein sequence ID" value="AFK06414"/>
        <property type="gene ID" value="Theba_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0697"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_0_0"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="433" mass="47422" checksum="88694F8D9CAFE11A" modified="2012-07-11" version="1" precursor="true">MWNALKNAFKIPELRDRILFTFLALAVFRLGVYIPIPGINIQAWSAYFGTLSTGGAGGFIGFFDVFTGGAVEQFSIFLMSVTPYINAQIMLQLLTAVVPSLKEMLKEGEEGKKKYARYTRMLTIGLAGLQGFLISFGLSSNTAILAIPSRLLFVLLATTTLIGGTMFLLWLGERITERGIGNGISVLIFGGIVARYPASIMQVVVALSPLQWGILLAIALFTVVAVIYVQMGERRIEVQYARRVTGRRVYGGVSTHIPIKVNQGGVIPIIFSSAIMMLPQFIATAFPEGSGGRNIMQSLFAQTSPLYILLYGGMVFFFTFFYSSLVFDVREVSDNIRNYGGYIPGIRPGFSTQQYIQRVLNRVVFMGAVFLVVIALLPLVIGGIFSIGGLAIGGTSTLIAVGVAIDILQQMETHLMVRHYEGFVKKGKLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F6</accession>
    <name>I2F3F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730513.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0744"/>
    <dbReference type="EnsemblBacteria" id="AFK06459">
        <property type="protein sequence ID" value="AFK06459"/>
        <property type="gene ID" value="Theba_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0744"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_3_0"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="296" mass="31516" checksum="E2E6E6F9B432BE62" modified="2012-07-11" version="1">MLEAIIRDTIKNSTPIVLAASGGLLTEVSGWLNIGLEGTILSAAFFAVVVSSFTGSVIVGTLAAILVAMALSSIIFFAVRYLKANLFVVGIAVNLLSVGITVTLAYNWFLSKGTVVFSDSPRPVVLSLDFLTGSGFGWLNGLSLFDLSAFVVPLFLLLFFKKTSTGVKLRSCGFDEESAFYSGVKVNDLRFLAYTGSGILSGLAGAALSIPMGAFVSNMSGGRGWLALVAVIMGRKNPLIVLLSALMLGFVTELSVFLQVATEISPKLLLSLPYFASFIILAISYGENKDKRFMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H0</accession>
    <name>I2F3H0_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Ribonucleoside-triphosphate reductase class III catalytic subunit</fullName>
            <ecNumber evidence="6">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0758"/>
    <dbReference type="EnsemblBacteria" id="AFK06473">
        <property type="protein sequence ID" value="AFK06473"/>
        <property type="gene ID" value="Theba_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0758"/>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002707_0_2_0"/>
    <dbReference type="OrthoDB" id="195920at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
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        <property type="entry name" value="NrdD"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="692"/>
            <end position="717"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="717" mass="82122" checksum="3912736EC4E50903" modified="2012-07-11" version="1">MLNVRKRNGAIVGFDLDKIINAMKKAFDATETHYNEDILERVALRVVADFQPKATDNLIDIEDIQDSVERTLESLGFTDVAKSYILYRRHREKLRELDSSMLDFSKTVNSYLDMLDWRVHENSTVTYSIGGLILHNSGTVTANYWLREIYDPQIGNAHREGDIHIHDLSMLSGYCAGWSLKQLIEEGLGGVTGKVSSSPAKHLSTLVNQMVNFLGILQNEWAGAQAFSSFDTYLAPFVKIDNLSLKEVKQNIQSFVFGVNTPSRWGTQAPFTNITLDWVVPTKLRTQPAIVGGKALDFTYGDCQEEMRMINRAFLEVLDEGDANGRGFQYPIPTYNITKDFDWEDEDAKLLFEITSKYGTPYFQNFINSDLDPDDVRSMCCRLQLDKRELKRRGGGLFGSDEFTGSIGVVTINLPRIAYLSKNEEEFFARLSKMMDLSSRSLEIKRAVVEKLNNEGLYPYTKRYLKNFDNHFSTIGLVGMNEASLNARWIKKAISEEEGYQFALRVLDFMRSKMMDYQEATGHLYNLEATPAESTAYRLAKTDKEKFPQIITAGKENPYYTNSSHLPVDYTRDIFSALDLQEELQQKYTGGTVFHSFLGERISDWETTKQLVRKIAENYKIPYFTISPTYSICPDHGYIRGEHFTCPECGKPTEVYSRITGYYRPVQNWNTGKQEEFKTRETYRVGREGVDEFRRNRERKPSGLSGESSSDTVYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H7</accession>
    <name>I2F3H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">Theba_0766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730534.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06480">
        <property type="protein sequence ID" value="AFK06480"/>
        <property type="gene ID" value="Theba_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0766"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_0"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="664" mass="68636" checksum="E6A9FE88DA86115B" modified="2012-07-11" version="1" precursor="true">MEMISAISAAVISLLSVLLGIYLFKWVSKHPVGSDRIREIGEAIREGANAFLRKEYTILMFFSIAICALLAIFLGLSSAIAFIVGAISSAIAGLLGMKVALKANVRTATAADKEGLSKAFLIAFRGGSVMGLLVVGLALAGVSLIYAITLKPEILLSFSFGASILSLFAKAGGGIFTKTADISADLVGKVEIGIPEDDPRNPAVIADNVGDNVGDVAGMGADLFDSYVASIVAAMVLGQTLGVKMVVLPLILASVGIVSSVVGIFSVRVRREKNPGRALDFGTYITSAVFALTTLVISLIMSYDLKYWGAAMAGLVAGTVIGFTTDYFTSIDRRFVKKTAQASQSGAAITILTGYSYGLMSLLPSLAGIGVASGVAFALCGVFGIAISAVSMLAIVGMVISSDAYGPIVDNAKGISEQSGLSEEVISMTDKLDAAGNTSKAITKGFAIGAAGLTVIALLATYQERVAAITGFTITFDLMNPLVMLGLLIGICVPALFSAMIMLGVSKNAFRMIAEIRRQFKEIKGLSEGTAKPNYARCVEIATTGALKELMLPSLIAIGITLLVAFIGGIHALGGFLGGAILSGLFNALLMSNSGGMWDNSKKFIEDGAFGGKGSDAHKAAVIGDTVGDPFKDTAGPSLNTLITVISLVASLISPLVILYAVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I5</accession>
    <name>I2F3I5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murJ</name>
        <name evidence="10" type="ORF">Theba_0774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730542.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0774"/>
    <dbReference type="EnsemblBacteria" id="AFK06488">
        <property type="protein sequence ID" value="AFK06488"/>
        <property type="gene ID" value="Theba_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0774"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_5_0_0"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="505" mass="54147" checksum="A7102D8E5C1760FC" modified="2012-07-11" version="1" precursor="true">MTASTVRSTAIFAIATMLSRLTGLARDSLFANYFGTSAQYDAYLVAIMIPFFLRKIFADGALTMAFVPVFNEKLKISRERAFVFASTVIVFVVIVAGSISAGGMVFSEGVASVFAGGFDKDALDLTSRLIRISFPFIALVSLWAVYCGVLNSLDAFFIAAVSPMFINLSTIAGILLSERFSPPIVGPTIGFLAGGVIQLVVVALAAKSKGFVFKPGYSKSDVREFLILFLFSAVSPAINEINSFVDVRVSTELGRGAVSSLGYAQRLYQLPLGVFAVAVATVALPRLSKLSGSDARDRFRKALWDSLTVLAFLIIPSTLGLLVLGEGIVRILFERGSFTPSDTAFTTSLLYGYTLGLPFYGSYGVLSRAYYARKSPRTPTIISAIMVSVNVALDILLGFTIGPLGVALATSVAGIVGTVTVSVALFRWSGYDREKIIAILKIILASLVMSCVMIVGRTLFGTGFISTSLTLVAGIIVYFLSARILRVGNLFKLRDLLRNKKSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N7</accession>
    <name>I2F3N7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ORF">Theba_0826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492528.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0826"/>
    <dbReference type="EnsemblBacteria" id="AFK06540">
        <property type="protein sequence ID" value="AFK06540"/>
        <property type="gene ID" value="Theba_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0826"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_3_1_0"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="92" mass="10320" checksum="21B4233B757CACC9" modified="2012-07-11" version="1">MPNNASAKKRVRQTAKKTMMNKAVRTKFRNASKKLYKAIEEGEDPKLVSSMLSEVYSTLDKAAKSGTIHKNTASRKKARLTSKVKTYVETRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S5</accession>
    <name>I2F3S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0868"/>
    <dbReference type="EnsemblBacteria" id="AFK06578">
        <property type="protein sequence ID" value="AFK06578"/>
        <property type="gene ID" value="Theba_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0868"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825860_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="36945" checksum="F8AB20972BC598DD" modified="2012-07-11" version="1">MKRVLVVSESNFPKGTKFRLSFIDATDPFRLSSIFEMETHSLVVSLAYKDGLIYCSMSKGFSIYDVSDLNSVKEISHIDLFGGIDMELSSGGDYAYLTSWKRGITIVDIHDPYNPSLIGRASCNYQVLPDDDSPYGPYGVAGIVVRGRYAFCVTCDYTDDKHREVFIVYDIADPSNPQQKVMISTAPWRSHGMVAQGDIAYASGFESILVFDISEPLDPVLINRHEQKARMCCNSVIRGNLLYNAGSDYAPEGSAGVLSIFDITNPLHIREIGETPTIGRVSWNLALVKDLVYVVSDGTISVVEIANPEKPAVRSLCGPSGADMVYDAIEIIDFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V0</accession>
    <name>I2F3V0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase Obg</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">obg</name>
        <name evidence="11" type="ORF">Theba_0893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492599.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0893"/>
    <dbReference type="EnsemblBacteria" id="AFK06603">
        <property type="protein sequence ID" value="AFK06603"/>
        <property type="gene ID" value="Theba_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0893"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_0"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="166"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="362"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="197"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="439" mass="48154" checksum="7CB60D5955C7147E" modified="2012-07-11" version="1">MLANDQESLVDTGRIYVKAGDGGNGSVSFRREKYIPYGGPDGGDGGRGGHVFLRASNSINTLYGFKHKKRFLAQSGESGQGSNMAGKKGKDLVIRVPVGTIAYNADSGEIIADLCNPGQTIVIARGGKGGRGNARFVSSTNQAPKAAENGEPGEELFVNLELKILADVALVGFPNVGKSTLISTISNARPKIANYHFTTLSPNLGVVMVSDSQGYIVADVPGLIKGAHEGIGLGHTFLRHIERCKTIVHLLDISESEERDFIQDYIDIRYELEFYKRELADKPEIVVANKCDLITQAERQKRLQLFKESTGKEIIPVSAATHEGTQALKEVIWRTIEGDSSYLSSMKGDEDTPLPQVEPVVLTAPYPEDFRVEKDSSGRYVVLGPAVDFYVRKIRAFKYRDRFIMDKLEKGGLSSKLRDAGIMEGDTVVIDDREYVFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y5</accession>
    <name>I2F3Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730660.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0932"/>
    <dbReference type="EnsemblBacteria" id="AFK06638">
        <property type="protein sequence ID" value="AFK06638"/>
        <property type="gene ID" value="Theba_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0932"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_1_0"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="278" mass="31097" checksum="35AF1D69CE8ECA4B" modified="2012-07-11" version="1">MLSNVNEYFRPKTVEEAYELMQNDRDHSIFLSGGTIVALMESSRIEKIIDLKFLRLDTISVTEGEIVVGATTTIESFRKDPVIRKEFDDFFYDAFSLVGSWQIRNMATIGGSVAPKLGWSDVSTCLLTTGSSLMIYGVDGYQRMLVSDYFSLPTGEKPLITHVMLKRDGWVSAFEKFSKTTFDIATVNVGLSIIPERNRIKGARVVCGSRPQYPARFESVEAAMTDLEINDVMPAIVRSLVYESFSGGSNMTASFEYRKHLASVLAQRAAEKVKEMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z3</accession>
    <name>I2F3Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492658.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0940"/>
    <dbReference type="EnsemblBacteria" id="AFK06646">
        <property type="protein sequence ID" value="AFK06646"/>
        <property type="gene ID" value="Theba_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0940"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_3_0"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="160"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="37143" checksum="B71A3060584BA7A9" modified="2012-07-11" version="1">MSSILRGKDFITTQDFDRTEIDLMLDLSSDLKRRFATNDPTPLLPYKTVFLMFFDQSTRTRNSMEAGITQLGGHAHYLDPSTMQTAHGEVPRDTAMILSRYGHAIAVRHCKFKVGNSYLRSLAENADVPILNLQDDIYHPMQVMADIMTMRERFGANLSGLKVAITWAYAESHLKPLSVPQSQILLFTRYGMDVKLAYPEGFDLMPDIVDLAKKNAEGSGARLEILHDMDEAFRDADIVIPKSWGGFYVSDDPQEIMTEVRRNKDWICTPERMKLANKRAIYMHALPADRGREVVDEVIDGPQSVVIDEAENRLHTAKAIMALTMGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F403</accession>
    <name>I2F403_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsF</name>
        <name evidence="7" type="ORF">Theba_0950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730677.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0950"/>
    <dbReference type="EnsemblBacteria" id="AFK06656">
        <property type="protein sequence ID" value="AFK06656"/>
        <property type="gene ID" value="Theba_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0950"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_0_0"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="18076" checksum="A26B36D4C59B301C" modified="2012-07-11" version="1">MKRIYETMFIVSPKLDEEERNAMAEKVRDYIVERVGGTIEKFDRWGIRKLAYRVAKGFSEGDYTVVQFRAEPETLDILERFFGITPDVFRWQTFRREDLEKAEKKASLKPAEAVEEPETVEVVESVEAAAETVVEDSSDEAAGVETETVEEVKQTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F425</accession>
    <name>I2F425_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730697.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0972"/>
    <dbReference type="EnsemblBacteria" id="AFK06678">
        <property type="protein sequence ID" value="AFK06678"/>
        <property type="gene ID" value="Theba_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0972"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654913_0_0_0"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="43156" checksum="A407C8A071888A30" modified="2012-07-11" version="1" precursor="true">MKKLLVTVLVVLSTALISSTVSVIGPWSGVEMDAFLPVLEEFKAKTGIDYTYQTYRAEDLANVLPAQFSAKKAPADVIFMWSNFITSNTQHVVDLSDVIDTDAYIPGALDNVKTSDGRVFGISYTAKVKPGFWYRKSFFESHGLKAPTTWDEFVALLEKIETIPGVKDAIASGNGVGWPLSDVTEHFLITFGGPELQKDLIEGNTTWRSYAVRNAMEKLVYLLEKGYFSEPTEWTTILEQWWNGDYGLYFMGQWITGMVDDPNDLAVFSLPGNRGMVFSIDYAFVPEYATNKAEALELVKFLSSVEGQSIQVAQGGHIATVGVDMSNYPAVDKEIAKLTEGVETLNDLDDSIGGLWQTAFWDQLKLIWVRPERLDDALMDLDEKMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F433</accession>
    <name>I2F433_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">Theba_0980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730701.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0980"/>
    <dbReference type="EnsemblBacteria" id="AFK06686">
        <property type="protein sequence ID" value="AFK06686"/>
        <property type="gene ID" value="Theba_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0980"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_1_0"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="23851" checksum="FDFC915F4FA84181" modified="2012-07-11" version="1">MHEINLVAELRNGEMKARSLLNQGKIPAVVYGPELETVPVSLDKVEILRIMNRIAETTSVVISIDGKEYHTFLKGVQRDKVTDSVIHLDFYVPSSGHKMELRIPIRLKGTPIGVEKGGIVDHIINELPVSVLPKDIVEEIIVDVSSFDVGHVLRVGDLEIPEGIKPLLDDEDAIMLIALPRAAKEVEEEEVEEIEEGVEPEVINKGKKEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F450</accession>
    <name>I2F450_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase of aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492735.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0997"/>
    <dbReference type="EnsemblBacteria" id="AFK06703">
        <property type="protein sequence ID" value="AFK06703"/>
        <property type="gene ID" value="Theba_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0997"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_1_0"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="367" mass="41627" checksum="8FA522DD43FAD0D3" modified="2012-07-11" version="1">MEYRRLGKTDLEVSLLGLGGFHLLEIELETVKEIVERYLEAGGNYFETARSYGDGVSERKLSLVLPKDGIIVASKTEGRDRKSSERDLLATLKALGREHIDILFLHAVTKNSDWEEISSSDGALRTIEWAKREGLISYVGITSHGYGGTLLRALKEYPFDLFMTQMNYYDRFNFPEIETKVIPFAVSNNIGIVAMKPLADGYLWRSTENAFRYTLTIPVSCIVSGINSIEQLEEDLRLIEKEPFSSEELDELLLTAPELGNYVCRQCMKCLPCPQGINIPGFFLAEGRYDRQMLDGKVRDAADYALRDRLAHWFGSEEQGLSEYSTISPGLDSCDDCGVCNERCPYEIDIPRKLRIVKSKFTEGYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F2</accession>
    <name>I2F4F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730802.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1100"/>
    <dbReference type="EnsemblBacteria" id="AFK06805">
        <property type="protein sequence ID" value="AFK06805"/>
        <property type="gene ID" value="Theba_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1100"/>
    <dbReference type="eggNOG" id="COG4907">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026556_1_0_0"/>
    <dbReference type="OrthoDB" id="556665at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="602" mass="67093" checksum="C4ECBDDCE34502F1" modified="2012-07-11" version="1" precursor="true">MKKIVTRVIIGLIIGLITWGIVVIIFSSGISDTFSSITSIEKADVLMEIDENGLLTVTETIDYVFKKPYRGIYRELPADRAGSQYSAIEVTAVGKEIKYIESFGSQDARSVRIWFVPYNTGAVSPVKGEERVSVTYKYTVRRAVEVGTDIAQIFRKIWGEDTASWVKKITATIVFPENLEILEFYTHPDAEVYREGNTYELEVTNVPPLTYVEFRAVIPKDQAMAMNMRNVALGGAFDKNYIDGVESGVRRKILFGKWIIPIAIGLLTPFVFILAHRKLGREIDVGYYAEYERDLPTQHAPDVINAAVKNLAGMVDNDGIGSTIMELYRREYIDFEKGKGDKVEGIVIKNRDVSKLRPTEAAFLEFLDKYDTGNVFDFSAVKKTVTKKQSEARIFTSDFSKYKSKVHDSVKGMHLIDLKGNAIAKGYSILMFVVCVILLAFYSGADLAPLRIFSLIFFGAIWVLCWIVMVLPKDVFGRWTREGRLFYLKWLGLKNYLEDYSLLNEKPPESIILWEEYLVYATALGIADTVRKNLNKIVPEDVWNEQSRHPYMYYPVTAYAVSSFTGVTRAAYSASSKGSGGGGGFSGGGSGGGGGGGGTGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F8</accession>
    <name>I2F4F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Theba_1106</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730808.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1106"/>
    <dbReference type="EnsemblBacteria" id="AFK06811">
        <property type="protein sequence ID" value="AFK06811"/>
        <property type="gene ID" value="Theba_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1106"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_0"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ACT_7" evidence="16">
        <location>
            <begin position="332"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="5"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFK06811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="399" mass="42793" checksum="DC286B73B1A1F0AF" modified="2012-07-11" version="1">MIVQKYGGSSVSDTERIRNVARRIRKKVDAGEKVIVVVSAMGKTTNELISLAESVTENPDPRELAMLLSTGEQVSAALLSMTLIEMGVRSISQNAMQLEISTFGDFDNARIADLNLDKIYAELEKHDVIVVTGFQGVDPEGNLTTLGRGGSDTSAVAIAAKAGVQCEILSDVPGIFTCDPKFHKDAKKLDYITYDEMLELAALGAKVLHSRSVEIAKKYNVEILCLSSFSEEGGTRVVNRLPEWLEQPVVTGATIDTNQLKIAINKLPGNTDIVSKIFQAVAGSSFNVDMISIVNDNGYIHLAFTVLSASPAAIKSTIESVLVDVDNWELAIDEDVAKISTVGVGMRSSAGVASRFFLALQKAGAKIIATTTSEIKISVLVPKSQAGKALKALLDEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H0</accession>
    <name>I2F4H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730818.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1118"/>
    <dbReference type="EnsemblBacteria" id="AFK06823">
        <property type="protein sequence ID" value="AFK06823"/>
        <property type="gene ID" value="Theba_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1118"/>
    <dbReference type="eggNOG" id="COG0451">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_0"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="36094" checksum="622E88C3A2146F70" modified="2012-07-11" version="1">MILVTGSTGHVGNVLVRELVSRGESVRAVALPGEDTSMIELEGVTVLRGDVRDRDFVIEACEGIDTVYHLAALISIMPTDKKRVQSVNVGGTENVIRACKKQKVERMIYTSSIHAFTELEPGSVIDENVPFNPARTSGVYGKSKAEAVLNVLTAAREGLNAVVLCPTGIIGPFDYKLSEMGNMIRLFASGRLRVGVDGSFDFVDVRDVVHSEIEASVKAKPGEVYIIGGESVSIQELTDILHQITGKKRIGTFLKSTSAYVLSAFSTLYYMISKTKACFTPYTVHTLTRNYKYSHEKASKVLGHNPRRVSESLRDAVEWLSGYGTIKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L8</accession>
    <name>I2F4L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1173"/>
    <dbReference type="EnsemblBacteria" id="AFK06871">
        <property type="protein sequence ID" value="AFK06871"/>
        <property type="gene ID" value="Theba_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1173"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="343" mass="39285" checksum="647AF19C0FB14EDA" modified="2012-07-11" version="1">MDKRLSTSAGVQENVAVTVVVPAYNAERFIERTLRTIIAQQGVDFEVIVVNDGSTDGTEEVVRSVLDSSQNSATFSRIIRTENSGVSSARNMGLISARGEYVIFFDSDDLMSKDCLSNIYRKARETRAEILAFGYDVVDFNGQTIRRFEDKYQYLCEPTDGRTVLLLMMKNKTWLWTGSVLYNKSFLRKHMHKYQAGATNGEDVEFTMKALYVAEKVVFEEQSLAKSVIRIRSASRINDYRHFHTVGALRRLRRFLEAHGAQREIMEMMDSNLIPRAYVGAIASLALGGFPSRKLINLMNVQIISEQIRRYEGQSMKDKLVKVLLMHFPNLYFSYLRYKGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N0</accession>
    <name>I2F4N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730871.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1185"/>
    <dbReference type="EnsemblBacteria" id="AFK06883">
        <property type="protein sequence ID" value="AFK06883"/>
        <property type="gene ID" value="Theba_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1185"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_0"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="311"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="463" mass="53421" checksum="7B9C142ADF9E1944" modified="2012-07-11" version="1">MFINREKELASLRKLKNSGKFEMAVVYGRRRVGKTTLLKEFSKEMESIFFVCDEVNEKMMLRNFSEVVLEHFGQKDTLSSFESWEKAIRFVASQAKEKRLLLIIDEYSYLANASSYFPSVLQRLIDHELLETRLYLVLCGSSVSFMESEVLGSRSPLFGRRTAQMRVEPFTYREASLFFPELSNEEKIIAYGVLGGIPQYLQKWNQHLPYKENIANNFLDTSAYLYAEPRFLLRQELREPSLYNTIIESIAQGASRLNEISTRIGEPNDKTAKYIATLLNLNILGREVPVTEKITSRKAIYYIRDNLFKFWYTFVFPNLSLIETGMTEELLNKKIAEGLSKYLGLAFENICREYLSYKSVRGELPFRITKLGKWWGNNPAKKKEEEIDLLGLGENQIIIGECKWTNAGVGVGELERLREKGSIIDCQNRIFVIFSKRGFTADLEELAARDASVYLATLDDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P3</accession>
    <name>I2F4P3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730884.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1199"/>
    <dbReference type="EnsemblBacteria" id="AFK06896">
        <property type="protein sequence ID" value="AFK06896"/>
        <property type="gene ID" value="Theba_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1199"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2554310_0_0_0"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="82" mass="9699" checksum="0F4AA9AD9A5D8EDE" modified="2012-07-11" version="1" precursor="true">MKTVNVRDVRNRFSEIVDRKEELLILRRGVPVMKISPVSKEDLMKYYLSKAQEEAEKIGLSEKEGLQVLEELRKEMKDEGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P5</accession>
    <name>I2F4P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase, imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730886.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1201"/>
    <dbReference type="EnsemblBacteria" id="AFK06898">
        <property type="protein sequence ID" value="AFK06898"/>
        <property type="gene ID" value="Theba_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1201"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046987_0_0_0"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="42530" checksum="6CBB024AA8BA94F2" modified="2012-07-11" version="1">MSILLKNGTIYPITSEPFVGDILINKGKIERIGQGLEESEAEIIDVSGKYVFPGFIDAHSHIGIYEEGVGGYYGDGNEATDPLTPDVSVVDAFNPQDTAIKRALSGGVTTVMVVPGSANPVGGQGAIFKFKKTLIVDDMVVRSPAGLKMATGENPKRVYGEGFKKTPSTRLGTAAVIRGYFQKVRAYMDKKKAAEKEGKPFTDFDPKLEVGEKVLRKEIPARIHAHRQDDILTAIRLSKEFDFDVVIEHATEGYKIVDFLKENNVPVVLGPIFGFRTKLELKDMSYDAPRILNEKGVLAAFMCDHPVIPLENTNVQLGVALRYGSKEEDLLKMVTINAAKILKIDERVGSLEVGKDADIAIWTKHPFNLAAKAERVFIEGEEVYSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P7</accession>
    <name>I2F4P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06900">
        <property type="protein sequence ID" value="AFK06900"/>
        <property type="gene ID" value="Theba_1203"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1203"/>
    <dbReference type="HOGENOM" id="CLU_2899016_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="62" mass="7005" checksum="A8F1B0B0213FB410" modified="2012-07-11" version="1">MGYVENCQSLFSLSHAYDEFLSLFGRLGTVDGQPCLHSVQRVFVLKRTADLLHEIPYRSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P8</accession>
    <name>I2F4P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS116/IS110/IS902 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1186</name>
        <name evidence="3" type="ORF">Theba_1204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730872.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1186"/>
    <dbReference type="EnsemblBacteria" id="AFK06884">
        <property type="protein sequence ID" value="AFK06884"/>
        <property type="gene ID" value="Theba_1186"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06901">
        <property type="protein sequence ID" value="AFK06901"/>
        <property type="gene ID" value="Theba_1204"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1186"/>
    <dbReference type="KEGG" id="mpg:Theba_1204"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674068_0_0_0"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="427" mass="49080" checksum="5C988B1C19AED5CD" modified="2012-07-11" version="1">MKEQSGMIVGIDWSADSHTCYDLKADKSFKIPDSVKGYERLLNDYPEAVFVIEEANNRIGDYLLTNKREVYVLPPCRSKEARKYHFSSGAKSDSLDAKAIALTFKEHPSYCLKARYSGVGAKITKLVTMYSIVSKIHSQQCNRLYSVLLRYFPEYLHIMDKQYRSNTSLRILSICPTITEFKKVSNEELRKILNKENYRMTSILRKKLDRIRSEGISWGDTSCEGNLIMFLANQILTLREEQERLRGEMGETLENSPYRIILSIPGVKAVIGSYIVKAYLTHDFRSYQEMQKYAGTIPFLFQSGRKSIMLMRKKCDKDLRNMIHIAAFASLKTCGWARNYYKRKRKEGKTYGHALRALGNIILKIAFSMLSKMKEYNETLFLNAKGINTTQQNNTIIPEAFTNPEYSQDAHPSLAATKDVVENLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q6</accession>
    <name>I2F4Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1213"/>
    <dbReference type="EnsemblBacteria" id="AFK06909">
        <property type="protein sequence ID" value="AFK06909"/>
        <property type="gene ID" value="Theba_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1213"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="254"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="569" mass="63991" checksum="863DBC0971AEF5CB" modified="2012-07-11" version="1">MERELFERILNSLIEGIIVVDSDETIAFINDEALEILGVNGEEATGAPVRETIPNTRLHIVLKSGEPELNRIQYLKEKTIVTSRFPIVNSQGEVHAAMAVFRDITNVEKMAEEVINHKEMEGLLTSIIDATYDAISVADEKGKIVLVNRAYTRITGMSPDFVIGKMATVDIAEGSSLHLEVVRTRKPIYNARLKVGPNRKEVLVNVTPLFVKGEFKGSVGVVHDISEIERLARELEDTKRLLRYMKAKYTFDDIAGSSKLMQVAIDQARKVSKTRATVLLNGQSGTGKELFAHAIHNSSDRREESFISVNCAALPENLLESELFGYVEGAFTGARRGGKKGLLQEANGGTVFLDEVAKMSLSVQSKFLKFLQDREIKPVGGNQTYKLDVRVIAATNVSLEKLVASGEFLPDLYYRLNVVPIVIPPLKERPEDIPEIARVVMMRLNQEYGRMVTEIDPAVLRMFEKHDWPGNVRELENVIGRAMISMELEEKTIRLSHIKGILEKPDKREKLPEGSLSTLLDDYEKEIIKDSLQRNDWNKTKTSNELGISIRSLYYKLEKHGITDTQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R1</accession>
    <name>I2F4R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase of the alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730901.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1220"/>
    <dbReference type="EnsemblBacteria" id="AFK06914">
        <property type="protein sequence ID" value="AFK06914"/>
        <property type="gene ID" value="Theba_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1220"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048353_3_2_0"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="249" mass="28468" checksum="1786315F7207E6BA" modified="2012-07-11" version="1">MSKLESFTFGEDGKRIFGICEYPRSGDSFPTVMMFHGFTGEHIVSTFKFPRLSRRLVEKGIATVRFDFRGSGDSEGEFCEMSPLTELRDAEEVYSFVRSRSWCSGKVAIVGYSLGGMVASLFAGRHPEISSLVLWSPVIMNQEFFNREDYSFKDGEEYKDVLGLKLGSIFFEDGRSVDASEELRNYEGDLLIVHGSDDESVPYLPVKRYANARRLMIHTVEGANHKYQRIDWIEELFSVSTDFFERTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S2</accession>
    <name>I2F4S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="8" type="ORF">Theba_1237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730908.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1237"/>
    <dbReference type="EnsemblBacteria" id="AFK06925">
        <property type="protein sequence ID" value="AFK06925"/>
        <property type="gene ID" value="Theba_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1237"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_0"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="134" mass="15001" checksum="A13D2E81D3268CB0" modified="2012-07-11" version="1">MADFVDYYGTGRRKTSVARVHLRPGTGKLLINGKEYKDLKEYLSNDAWVRSALKPAVVTNTIGRFDMLIRVNGGGLGGQAGAISLGIARALVKFNPDLKKLLRQNSLLTRDPREVERKKYGLKKARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z1</accession>
    <name>I2F4Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginine/lysine/ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730966.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1306"/>
    <dbReference type="EnsemblBacteria" id="AFK06994">
        <property type="protein sequence ID" value="AFK06994"/>
        <property type="gene ID" value="Theba_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1306"/>
    <dbReference type="eggNOG" id="COG1982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014292_3_0_0"/>
    <dbReference type="OrthoDB" id="485164at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1" evidence="4">
        <location>
            <begin position="146"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="6">
        <location>
            <begin position="630"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="781" mass="89887" checksum="5778686F925C025B" modified="2012-07-11" version="1">MELFKDFPVLVVDDDLRSENTGGRATREIIKELQKRGFSVIESYSGYDCRIEFMSHSNVSCVLLDWDLVIKPDAEFLGPGEIIEIIRGRNMLIPIFLMTEKLRVKEIPLEIVSQIDGYVWKLEDSPSFIAGRIEEATERYMDELLPPFLKELIRYVDEFKYSWHTPGHSGGEAFLKSSTGKIFHKFFGENIFRSDLSVSVPELGSLLEHTEAIGESEKSAAKIFGSDETYFVTNGTSTSNKIVFHYCVTPGDIVLIDRNCHKSIMHSIIMTGAIPIYLTPSRNSLGIIGPIHEENFEWSEIEKAIKESPLVEDKENYRIKLAVITNSTYDGLCYNARTILDRLEKVVDFVLFDEAWYAYAKFHPMYLGRFGMSSDIDRERSPVVFSTHSTHKLLAAFSQGSMIHVKDGRKRVDHGRFNEAYMMHMSTSPQYAIIASLDVAAKMMAGNAGRFLIDETIQEAIIFRKKMKHLKKEIESKETDRKRRWWLEIWQPDKVSIETESGERKTFDLEDIDESILKDRPDCWYLKANEDWHGFGKLDNDYALLDPVKVTVMTPGITRQGGMRNWGIPATIVTAFLRHRGIVVEKSGHYSFLILFSLGLTKGKSGTLLAELFTFKKLFDEDAPLDDVFPDIVREFPKKYGKMTLQELCRQMHEYLRKVKITKVLKDVYSQNPEQVMLPAKAYAELVNGNTELVRIRELQNRISAVMVVPYPPGIPVIMPGERYTGETKRIIEYLNLSEEFDNKFPGFENEMHGLKMKIDSANKKRYYTYCLKEIEQEDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F514</accession>
    <name>I2F514_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="10" type="ORF">Theba_1329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486733.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1329"/>
    <dbReference type="EnsemblBacteria" id="AFK07017">
        <property type="protein sequence ID" value="AFK07017"/>
        <property type="gene ID" value="Theba_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1329"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_0"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="286"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="575" mass="65976" checksum="132B5715A5758EF5" modified="2012-07-11" version="1">MNEAILNKASQLPEEPGVYIFKNEKDDVVYVGKAKKLKRRVLSYFRESTWSKNEKARCIAEEAEDLDFIMVTSEREALLLEANLIFNKKPKFNVLLRDSRTYPYIYISADQYPYLAITRTKELEGSYFGPYTSAGLVRKLLEFLQKVFKIRTCTYELSRVKKPCFLYHLKMCSAPCVEKVSPEEYREQLSALIEFLEGDTLKVREALLKRMAVLSEALQFERAAEIRDILSTMDDLYAFQGVEAPLDLKADVLAVSAGLAALLQVRGGMLLGKLIFDFPEGTPIDFITQFYYAKGNRMPKALIVTGLKKKDIKQFKRDFPYIGEPRDEQEERLLSIAFKNIDEEMKIRLNATHSLKQAQQILGLKRFPSRIEGIDISHTQGLYTVASVVVFDNGKPNKSEYRRYRISELEEPNDFEAMATVVKRRYTKHPLPDLLLIDGGEPQLRAVEKAFAEIGIQEYEIVGLAKEFNELVFLDNRDRVKLKEEHPVLRMIISIDDEAHRFAINYHRVLRERRFQSSKIDDIPGIGPKRKKALMRAFGSVKGIAEASEADLYSVLRNSKAVEAVTKWANEKSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F543</accession>
    <name>I2F543_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730992.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1358"/>
    <dbReference type="EnsemblBacteria" id="AFK07046">
        <property type="protein sequence ID" value="AFK07046"/>
        <property type="gene ID" value="Theba_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1358"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_4_1_0"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="331"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="596" mass="66018" checksum="53BF7662AA6CEFD7" modified="2012-07-11" version="1" precursor="true">MNWKKGIPAVVIVLFVAALVPVVAFGTVTVHELVVLGTTDLHGYVMPYDYLTVKEVSDYGAAKTFTLIKWAREMYNNTILIDTGDAIQGSVLAEREARIDPIKMGDTPSIIKAMNIMDYDVVGIGNHEFNFGLEYLDLAIASADFPMISANLYNEDTKELRYDPYVILEREVDGIPIKIGVIAFLPPEIMMWDRVLLEGKVYAEPIVDAAAKYVPKLREEGVDLVIVSLHQGSSDAEAILENVEGIDAIIMGHSHGKIADKIDGVPVTMAGSWGNSLGLIHFHLLNIDGEWEVFSSCPQLWHVDEKVEAAPEIVEAVKEQHEATIDYVMAPVGTTAVPIKGYFSRVIDNEVTQLVNEAQLWYVKEYFKGTEYESMPLLSAAAPFRTNTSVDAGDVRIMNAADIYIYSNTLHVVKVNGLELKGWLEKSAENFNQIDPNSTEEQNLLARFSSYNFDVIEGIDYQIDVRNPVGQRIVNLTYEGEEVEDDMEFLVVTNNYRAGGGGYHLVDADIVLSSTVENRSVIIDYIIEKGTINPTPSFNWSIVPFESAGKITFSSSDEAATLPEELGIKGIKYIGDRLFEVDLIELAENVPQAVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F567</accession>
    <name>I2F567_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Zinc transporter ZupT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">zupT</name>
        <name evidence="13" type="ORF">Theba_1382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates zinc uptake. May also transport other divalent cations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731016.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1382"/>
    <dbReference type="EnsemblBacteria" id="AFK07070">
        <property type="protein sequence ID" value="AFK07070"/>
        <property type="gene ID" value="Theba_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1382"/>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_3_0"/>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00548">
        <property type="entry name" value="ZupT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023498">
        <property type="entry name" value="Zn_transptr_ZupT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="28077" checksum="EF43CC177D62BAE5" modified="2012-07-11" version="1" precursor="true">MELENFWTALFLTSFAGLSTGIGSILAIFTKKTNTKFLSVSLGFSAGIMIYVSFVEIFVKSGESLQKAMGDGISNWVNVIAFFGGIGVIALIDFLVPKAENPHEMRDVDEMEASSKTLLRMGVFVALAIAIHNFPEGLATFLAALEEPSLGIPIAFAIAIHNIPEGIAVAVPIYHATGSRKKAFLYSFLSGLAEPAGALIGFSLINILFNEIAFGVIFAGVAGIMVYISLDELLPSAEKYGKHHLSISGLIAGMGLMAISLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F586</accession>
    <name>I2F586_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type branched-chain amino acid transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731034.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1401"/>
    <dbReference type="EnsemblBacteria" id="AFK07089">
        <property type="protein sequence ID" value="AFK07089"/>
        <property type="gene ID" value="Theba_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1401"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="33794" checksum="DEFD1C5952875BDD" modified="2012-07-11" version="1" precursor="true">MKITKSLVIIILLIAAALLPVVTEAYFISVAITILTFMTLSISWDMMLRTGQLSFGTAGFFGLGGYTGIIAVADFGVDPLVGIILGGLLAGGVSLLLGMAILRLRGLYFAITTMALASVFMVVIRNLNKLTGGPSGKIVYTTLFNYDSVKVYWLMLGITVGTIVVSEVFQRTRVHFAIDSIRADETVAKSHGVNIYKYLIFVFVVTSIIQGVIGSTYALQYGFVYPESSFSAHYLLLPIAMALVGGIYSTIGPVLGAIILGLSSEYLKLIMPYGHLIFYGVIIVVVVLFLPNGVYGAIKDVTGFRKRRLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F587</accession>
    <name>I2F587_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731035.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1402"/>
    <dbReference type="EnsemblBacteria" id="AFK07090">
        <property type="protein sequence ID" value="AFK07090"/>
        <property type="gene ID" value="Theba_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1402"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_1_0"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="309" mass="33426" checksum="DFB0D20573FE17E4" modified="2012-07-11" version="1" precursor="true">MESISFLRKHRNLFLLIAVIIVVAIWKPHAAIYGLQRGSLYSLVGLPLSLTLGVVGIMNLAHGDFLSLGIYFVYLFATNLGMDPLVSIIPVFFLLFGLGVVIYKLTITRVMKSGHLNQLLLTFGISMIVLEAMNLIWTSRPRSVYVEYSSSSTTIAGVRFGTYELLYVVFAFAVLIALQLFLKKTRLGQATFAVGQNPQGAKIVGINTGFVYLFVFGISIAILGIAAGVMVPRFAIFPSVGSAFTMKSFCLVAMAGLGNLPGILVSGIVLGVGEAIVQSIPGYAGWSDIVFFGVLIAVIMIRSLRRQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F594</accession>
    <name>I2F594_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731042.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1409"/>
    <dbReference type="EnsemblBacteria" id="AFK07097">
        <property type="protein sequence ID" value="AFK07097"/>
        <property type="gene ID" value="Theba_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1409"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_0"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="269" mass="30671" checksum="B36F43D25D758460" modified="2012-07-11" version="1">MALLRTSDGTQIYYEVHGDQSNPPVVILNGIMMSVPSWAGFVPHFSRHFRLILMDFRDQGRSERKDSQYHISIHVDDLTDLIDALEISSANVVGLSYGGQVAEMLAIKRPERVNSLVLANTPARISPYLAELGEAWKEAAELKDGERFFKLAIPFIYSDFFYNRNLQWLKERQKMFKSTLNGEWFEGFIRLISSNPDFNVLEELDKIQCPTLLLGADRDIITPIEEMKAIHERVRNSEFLVIKDAGHGAFLEKPGEFMTAIIGFVLKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F595</accession>
    <name>I2F595_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphosugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1410"/>
    <dbReference type="EnsemblBacteria" id="AFK07098">
        <property type="protein sequence ID" value="AFK07098"/>
        <property type="gene ID" value="Theba_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1410"/>
    <dbReference type="eggNOG" id="COG2222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831078_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="334" mass="37177" checksum="0FF5D966207863FE" modified="2012-07-11" version="1">MSKFLEDMLEQSEAVRTIISTSDVVFEKAKSLNFERVLFTGMGASLHASEVAASFLRYSGIDAESFEMSEIITYSSQELLKRYSTIFLISQSGESAELIRFIEENKALLPSMTLVTNNEKSSAAKAFPDERVFPLFAGNERSMGATKTFVNSIVLTLMISAFRTARRLNFSDLPTRMDEALSHDLSWLAAMLSEKRERILVARGFGIGVGKMARLMFAEVAKLSLIFYSGASFRHGPVDLLADKPVVITMNPKGETYDLMQELHNDIYDKCDLITLTNSREGNVKSIYVSDGLEEVLAFIPMMNLLQKTAEEIARNRGFDPGSGVFGTKVTTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F598</accession>
    <name>I2F598_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731046.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1413"/>
    <dbReference type="EnsemblBacteria" id="AFK07101">
        <property type="protein sequence ID" value="AFK07101"/>
        <property type="gene ID" value="Theba_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1413"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_0"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="131"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="37327" checksum="F4072D4B2C70EF21" modified="2012-07-11" version="1" precursor="true">MHSIAILGAGMMGNVHARAYRAIDQRNSLWIVDPIESRAKAISEKYGATVASFEEVLENSSVDIVGICTPTFTHRELAVRALKAGKHVFCEKPVALTLEDARAMDRAAKKSGRKFMVGHVVRFFPQYIRVKELAAAGDVGEIVMARLYRGGSFPSHGIDNWFADITKSGGVFVDLSIHDFDFLRKLLGPVKTVEARSVTLSSERKKNSFDHGMAILRFESGALAHIEGSWAEPAGMPVNFGTFYEFVGTKGMITNSYERETMLRLQTSIDGKPRYLQENPAYFDPYTEELKSFILSVEKDREVPVNGQEAIESLRVALAANMSAKLHRSVELSEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I7</accession>
    <name>I2F5I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase specialized sigma subunit, sigma24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487080.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1508"/>
    <dbReference type="EnsemblBacteria" id="AFK07190">
        <property type="protein sequence ID" value="AFK07190"/>
        <property type="gene ID" value="Theba_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1508"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_0_0_0"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Sigma54_DBD" evidence="2">
        <location>
            <begin position="253"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="396" mass="45348" checksum="42EEDA0292AF0796" modified="2012-07-11" version="1" precursor="true">MELNHNVSQRLEQKLGLSLKAQQALKLLQLNSMEITAELEEIVQANPLLEMKREDYELIEGKSDLESSPEDEENTEDGDLYSLPENNSIYMKPESTDRDGWDFDRIEAQQPTFREILRDFAFYILDDDLFSLFEILLDYMDDLGMLTEDLEKIARENHCSVDGLSSVISTMRDGGFDGIFASSREEIEALLGPGLFPSSGYSDGAFVRYVEPDLYIEFIDEKFIVTVRDYSLVLSVDESYEEIMEHGEKKAKKYLEEKLEEAKFYISALERRKATLITIGNEIVIRNAPFLLKTSEKIRPLKMNSVADKIGVVVSTVSRAVKDKFVQTPVGTFPIRYFFGNLQEKEQALEVIAEIVRGNPEISDAELVTELNNRDINIARRTVNKYRNQLGLRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M3</accession>
    <name>I2F5M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731136.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1553"/>
    <dbReference type="EnsemblBacteria" id="AFK07226">
        <property type="protein sequence ID" value="AFK07226"/>
        <property type="gene ID" value="Theba_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1553"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640615_0_0_0"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="428" mass="48109" checksum="3614F0574CBD0820" modified="2012-07-11" version="1" precursor="true">MAKKVAILLVVSLISSAMLFSGTLSGYLTERMGWTYIASGSDVEMSIYPPEGVSAIADERIFYGQITIGDSTVNIAIMNVEPPILWIDSDYDGCFLNNIPIKGQYRGTVINESRAYKFSQQLRVEYLSNGNSSYMTQDLEIHAILPKKEGVEVDYLLMSRREGLLEVDGELIEIALFPTAPDGLADKIDEVFIGIDLDRDGTIDMVHKNHELFEATSVIRINDKNYRVSEISRDGRKVTFEQVDEDAQNRPLLKKGSIAPLFEARDVFGETFSMSDYLGNPIIVVVTSKTPLEVFNGGFPCATGDCEDTGREEKRLRSLLNELVTWNEYSAKPEIELLWLYSGDEITSADSLEEYSWLHLIADKSAVELYSTPLSNGMFLISKDGRIEYLDDYVLQAGDGPIPTYPVFRIPTFGLTSYIWFRELVFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M9</accession>
    <name>I2F5M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731141.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1560"/>
    <dbReference type="EnsemblBacteria" id="AFK07232">
        <property type="protein sequence ID" value="AFK07232"/>
        <property type="gene ID" value="Theba_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1560"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071528_0_0_0"/>
    <dbReference type="OrthoDB" id="584516at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="334" mass="38334" checksum="96D5762DDABFADC1" modified="2012-07-11" version="1">MQLNPDFSYEKKKIEFSSGYIFKGKHYRCSIIKYPSFYRNKIRGTENVEIYNFSPRERAVGSIIILHGLGTVNIPFLFWMGSHLASAGLQASVMILPGNYTRTATGSTSGKDFFSPDLRRLIVFWEQAVVDTMTTIDLLQQEKLWWDNNCLFGYCLGGMISTIVNAIDQRINDMILMTVGGNIAKIIWQSPVLKSIRDSLRSGSGKEGYLNDEVKLNARFEEDARAVKLIKSAHELIESDLHPLFKIDPLAYARFNDRKKVTMIEALFDKTLPIETRKQLWEAFGRPKRYIVPVGHVSWFPFEYALGKFILKKLGIKEARRNLRLLESTKPTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N7</accession>
    <name>I2F5N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731147.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1568"/>
    <dbReference type="EnsemblBacteria" id="AFK07240">
        <property type="protein sequence ID" value="AFK07240"/>
        <property type="gene ID" value="Theba_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1568"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010079_0_0_0"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019248">
        <property type="entry name" value="Glucodextran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09985">
        <property type="entry name" value="Glucodextran_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657770" evidence="1">
        <location>
            <begin position="23"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="31"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="836" mass="94582" checksum="B10CB78225310A13" modified="2012-07-11" version="1" precursor="true">MKKVFIALLLMLFVTPICLSSAVWEDQVVYFLMIDRFSNGDPSNDDMGLGEAGSDNSRYNGGDLKGIIDKLDYIKGLGATAIWITPPVANQWWNPWVNYGGYHGYWARDFKRIDEHFGDIALYKELVEKAHEKGLLVIQDIVPNHVGDYFRFVDGEFEMNSGSVPSDSPEQYPFSLNNFVEHRDENIYHWTPDISNFNDQDQKFNYQMSGLDDLNTENPSVISALKDSYTFWIDEADIDGFRIDTVIYVPHEFWREFLNGESGVYEIASKNGKLNFLTFGEAWVRSDPFEDTGERVIGEFFESGMNAMLDFPLNIELRSVLKEGKPTANLGYRLETRQSYFDHTRLLTFIDNHDMERFLKGAGLASLKQALAFIFTVPGIPVVYYGTEQGFVETRAAMFEDGFQSGGLNHFETQSELYKYTSDLAKLRLEHPALRYGRVEVLKSDPNGPGIFAYSLEHDNEKIYVIMNTAGERRILANMESGLAEGQVIKPIYTFNSLSKSYPVDEDGKLLMTMNPRSVYVGVASEEYQSVESPEIQFIANLEYAQKIASTYTITGTASGASSARIIFDARIEEAEDIEIEDGQWSYEWDISKFDPGIHSILFKVYGRTKRESIYSEDYTVVLDIPELLLSSLSDPEGDDKGPEGRYEYPTDISFKNQMDLLGVELRQIGASLSLNMRIKDLTDTWGPQNGFDHVTFQIFIDDPHKTGSTVLPFLNATMPAGLDWDYFIFANGWSIVAYSAEGSGPKSFGTAISPTPLVQTNKMKSEVVLRIPGETIGRPESLNGFKVYITTWDFDGIEAVYRDIYPEPKSYHFGGGSKEDPYIMDDILLKIGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T0</accession>
    <name>I2F5T0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731182.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1619"/>
    <dbReference type="EnsemblBacteria" id="AFK07283">
        <property type="protein sequence ID" value="AFK07283"/>
        <property type="gene ID" value="Theba_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1619"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133784_0_0_0"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="12"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="20030" checksum="247A54B8E3A55FC7" modified="2012-07-11" version="1">MEITERQPRIGGNAINYLHYCKTQLWFFLHNISMESTSESVQLGKLLQEEYSQGEDKDIVIDEISLDILRNTREIVEIKYGKEVREGHIYQVKYYLYYLKHKLGLHEFTARLTYPRAKKMIMLSLTEEDEEQIRRDLDEIKTIFNLDNAPLPLFKEGCKGCSYFDLCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5V5</accession>
    <name>I2F5V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731203.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1645"/>
    <dbReference type="EnsemblBacteria" id="AFK07308">
        <property type="protein sequence ID" value="AFK07308"/>
        <property type="gene ID" value="Theba_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1645"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540588_0_0_0"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="537" mass="61034" checksum="BF77A6F7A70EFD37" modified="2012-07-11" version="1">MDNFDYYVAGRRAYFFGGIDGNAENIGWHLKGKMGGFWLDKYRLFSSYFLSLNGKRVSPTSFQNKVSERIVNYPGADLRILAHPERPLIAIRIESRAKIEFCLRQEMDLVWLEDRPSGNISLRVENQDRDTIVWRELEGMSSFVKVNGKATSEGDWLKLSRRGRLEAVIALGRPGKEGYEQYLLEREEHNRRYLPPFQDTIPFWARAGALELFFERDVGCGFVAGLGEFPWWFGIDGVYTCLGLLDTPMLELVGKTVDNLAKFGNGLAPHEVTTAGRIYAYGRMNEIIAFAYLALKYAVKTSKKEYLELVDNALSHVSGHLSRKLYPQGEGIVEVPISGEFALLDSACWLYSMLKELRDSNMMKDLKNSQFAAWLLERYDREFLKDWYGKDGLFYDALTEKSGNFEGHFIQIYPLSMGLIRREIGERLLAKMEKIGYFKEPGLIHSLPLKTFEAGDYGEGDKNDIVWSLPTLLAIEAGIRYGRPDLSEKFILSLENSLKSEMYGALPEILPAGGCTIQAWNAYAIPLIEHMNSPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5W5</accession>
    <name>I2F5W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC-type transport system, periplasmic component/surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1655</name>
        <name evidence="5" type="ORF">Theba_1732</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
            <strain evidence="4">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731213.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1655"/>
    <dbReference type="EnsemblBacteria" id="AFK07318">
        <property type="protein sequence ID" value="AFK07318"/>
        <property type="gene ID" value="Theba_1655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07389">
        <property type="protein sequence ID" value="AFK07389"/>
        <property type="gene ID" value="Theba_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1655"/>
    <dbReference type="KEGG" id="mpg:Theba_1732"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_1_0"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="35883" checksum="6F7A2F0AAAD2FD78" modified="2012-07-11" version="1" precursor="true">MKRMILVLFLLGIVATGFGALKVAIVAGDAIGDRGFTDMAYIGIQEAEKQFDIEYKVFECHVDPSKYFDSLRAAAMNYDLIFVDPGYFFDKELAEVSAMFLSKTFVYIDGASDLPNVVSVPFKQNEGAFLAGCLAALLTDKTELCKINSEKIVGFVGGFDMPVIRDYQVGYEHGVRYVDPEVKVIARYAGDHYDPALGKETAYSVSKEGADVIFQAAGPTGLGILEAAKDYGFFAIGVDTDQGYLQPGFIVSSMMKKVDVAVLDIVRMQVENKLEKGSLHVYGIANGGVGLAYNEFMMDTVPASVYIEIREIQEKIANGEIVVDSYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F619</accession>
    <name>I2F619_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1638</name>
        <name evidence="6" type="ORF">Theba_1715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
            <strain evidence="6">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489306.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1638"/>
    <dbReference type="EnsemblBacteria" id="AFK07301">
        <property type="protein sequence ID" value="AFK07301"/>
        <property type="gene ID" value="Theba_1638"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07372">
        <property type="protein sequence ID" value="AFK07372"/>
        <property type="gene ID" value="Theba_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1638"/>
    <dbReference type="KEGG" id="mpg:Theba_1715"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="331" mass="37105" checksum="CBD7E2E8BF7247F4" modified="2012-07-11" version="1">MVTIKDVAAEAEVSIATVSRVLNGSGYVSEDTKLRVLRVINRLNYHPMPSIRKKSLYRTLGVLLPNTMGNHYGEIFMGVEDYAHKNGFNVMLAMAREMVSREQEILNEYFQRKVDGVIVATLHSDEHMLNRFIESGIVVVAVDSPIREIKADSVNIDNSFAAYNVAKFLYEKGHRRVLFLPGQEGVHASKDRLKGLRKFASRTSDFDLKVARIGGFEPHHGQEAIRDYLRDFGIDFTAIFAVNDHVAMGAMQELHKNGVRVPDDVSVIGFDDSVHAPYTIPALTTVSQPRIEMGSAAAQLLIERLRLTQKRVFRNIVLPTALVERDSVKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F692</accession>
    <name>I2F692_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731276.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1794"/>
    <dbReference type="EnsemblBacteria" id="AFK07445">
        <property type="protein sequence ID" value="AFK07445"/>
        <property type="gene ID" value="Theba_1794"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1794"/>
    <dbReference type="eggNOG" id="ENOG502ZB4E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036670_0_0_0"/>
    <dbReference type="OrthoDB" id="1065636at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041113">
        <property type="entry name" value="Heliorhodopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18761">
        <property type="entry name" value="Heliorhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="254" mass="29155" checksum="0E92B2B1535C4CE4" modified="2012-07-11" version="1" precursor="true">MESVYKKLRIYNLIMGFLHLVQGIIMLIVSNDSSLTITRNYLEFDREIMRLVPATENFMDLKMGPFIASFLFMSAIAHFIVSTFGFGWYARNLQKGINYARWYEYSISSSVMIVAIAMFSGMLDIVSLMLLFTVNALMNLFGLMMELHNQTTERTNWTAFIFGCIAGAVTWIAVFVYFFTSLGKANVEFPSFVYAILITFLVFFNSFAINMFLQYKKIGPWKNYLFGESMYVLLSLVAKSVLAWQVFAGTLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6A0</accession>
    <name>I2F6A0_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1802"/>
    <dbReference type="EnsemblBacteria" id="AFK07453">
        <property type="protein sequence ID" value="AFK07453"/>
        <property type="gene ID" value="Theba_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1802"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_0"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="116"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="482" mass="51119" checksum="2440A33888D2D9D5" modified="2012-07-11" version="1" precursor="true">MNPVWLIAIPLALAFVSAFWRSVSGWALLVAAFFNAFAGVFGVMFLTATSFSIGGWKAPYGINLLVNDATKLLLPVANILFLFAVLSYLRKGEETKKYSVVFLVALASLNGILLTNDLFNLFVFLEIAGISAYLLASTGEGSGSKVASFKYLMIGSVGSLLYLLGVAVLYGAAGTLNISELAARISSGQISGDVTLVSSLLIVAGLGVESKLLPFNGWVPDVLTKSSRIATLVLASVYPLAMVNAFSKVLLAVGDDRAMTLVILLGTATVLVGEVLAFSQKSLRRTLAYSSIAQSGLAIFLVGIGSVEAITASIMLLINNALSKFMLFSVDDKVIDEVGRDDRDTLNGFGRKSPIVGVIFVISALSIAGMPLFFGFRGKLNAISASFETSMAVPIIILIAAAIEVTYYFRWIFTFFKPVGTAQTPEKRMVPSVEFLAFGLVLSTVIVFLGVSSGEAFMMFERAADSLVNGILAIGKAILGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B3</accession>
    <name>I2F6B3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488422.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1815"/>
    <dbReference type="EnsemblBacteria" id="AFK07466">
        <property type="protein sequence ID" value="AFK07466"/>
        <property type="gene ID" value="Theba_1815"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1815"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_1_0_0"/>
    <dbReference type="OrthoDB" id="1083771at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="3">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="278" mass="31628" checksum="7774A0226D304F72" modified="2012-07-11" version="1">MFYPGHIQKAKRQIQNYIKSVDGIVELLDARIPLSSRAYEAEKLFQKKQRIVVLNKSDLADPKITSMWRDYFKSEGSDVVEASLRSTDAKQFIIREIVPLLKSRFYEKRFMVVGTPNVGKSTFINRLKGKKSLAVGNRPGITRGVQWINVSESIAVLDTPGILYSDLRSPHITTKLLAVGSLPYEKFDPLDAFERVLALIVERYGKGLLEDYLGEEFSNQEEFVEKFCRRRNYLAKQGALDTTRGAHTFLREVAAGKAGRLSFEDPESFYTSDSPEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C8</accession>
    <name>I2F6C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">Theba_1830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488389.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1830"/>
    <dbReference type="EnsemblBacteria" id="AFK07481">
        <property type="protein sequence ID" value="AFK07481"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
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    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="22"/>
        </location>
    </feature>
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        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
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            <position position="77"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="84"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="16686" checksum="D0E6D119BB51286D" modified="2012-07-11" version="1">MKILILNGPNLNMLGMREKSLYGSFTYSELSEAIERKCLESGASSELFQSNHEGDLIERIHNIDYDAIVINAGALTHYSYSLRDALELFRGIKIEVHISNIFAREEFRSKSVISPVCSGTIAGLGLNGYLLAIEYAVSHLKSLTDREATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E5</accession>
    <name>I2F6E5_9BACT</name>
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        <submittedName>
            <fullName evidence="6">ABC-type Fe3+ transport system, permease component</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">Theba_1848</name>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="gene ID" value="Theba_1848"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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        <property type="entry name" value="MetI-like_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
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            <end position="172"/>
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    </feature>
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        <location>
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            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK07498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="564" mass="61559" checksum="E91956BF61CC88D0" modified="2012-07-11" version="1" precursor="true">MAIRGEEAKNRFLNLLKDPVLLLIIVLIFAALAIFIVYPLFRVFAVSMTDKEGGFDLSAYSHAFSNRYMRQGFFNSLLVAGLTAIFGMLVGYLFAYTLNRTDIPLKGFFRTVAVLPIVFPPFIGALSIIMLFGFNGIITAGIFGIRNFPVYGLWGLMMAQVVCFFPVAFITLDGVIGTISPTLEDAAFNLGANRWQAFRKVILPMSVPGIASTMLVLFIESLADFGNPLILAGSKFPVLSVQAYLQITGMFDTKGGAALAVWLLFPSIAAFIIQKYWVGKKKYVTVTGKPTTSVLKSVSKPVKWILFSLCMLIAVFTLTIYATIFWGAFVKAWGMNNTLTLENFKYVFDVGLEAIKDTLVIAFTSTPISAVLGMIIAFLLVRKVFPGRRVMEFTSMLSFAVPGTVIGIGYILSFNKPPLLLTGTLAILVLNFVFRYIPVGIQSGVALLNQVDPAIEEAAYTLGADNRQVFTKVTLPLIMPAFFSALVFAFVRAMTAISAAIFLVSARWNLITVQILSQSDSGRLSEACAFSVLLIGMIMGFILILKIFLKNKISLSSGGTAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F3</accession>
    <name>I2F6F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488325.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1856"/>
    <dbReference type="EnsemblBacteria" id="AFK07506">
        <property type="protein sequence ID" value="AFK07506"/>
        <property type="gene ID" value="Theba_1856"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1856"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_0"/>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="44732" checksum="8B2B4640C5E93A3D" modified="2012-07-11" version="1" precursor="true">MDNTKKAWLVVFSGLGVNLTLGVLYSWGIISAALIDDFKWTATQTQIPYMLASAVFALTMIPGGKLQDKFGPRPVLFVSSILAGLGFFFSGLNLSVAGLTFFFGLVFGLAMGFGYSSPTPAAVKWFHSDHRGLISGIVVSGFGLAPVYIAPLTSGLIGLFGLPTSLMILGLLFFLIVFTLSFFISNPQEGVEKVRLKKKPRKVHRLTSKDYTLKEMVRTPQFYILWTMFFFGTFAGLLIIGQMSKIGLEQASISNGFLLVVVYAIFNFIGRVTWGSISDFIGRTATLFAMFAIQALVYFLFSSLTNPLALLIGKSVVGFTFGGMLAIFPVVTADFYGVKNLGVNYGVMITAWGVGGVIGPLLGGIARDITGGYEISYIVSAVLSVAGALLSLVIRHPEEEKREKNGGRADAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F4</accession>
    <name>I2F6F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731319.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1857"/>
    <dbReference type="EnsemblBacteria" id="AFK07507">
        <property type="protein sequence ID" value="AFK07507"/>
        <property type="gene ID" value="Theba_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1857"/>
    <dbReference type="HOGENOM" id="CLU_2093958_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="13502" checksum="FD35AE76406974F7" modified="2012-07-11" version="1">MQKRTEKLKKIRKTLAVLSDDVQWKLEDVVLTIGDLIDEDKKVTIDVLREIGSMDSRRKKLFMLYMKASEERDALMKQRIEDLWSVEDDELEEVLKGLSKHSIDDGKTPKEPPSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K1</accession>
    <name>I2F6K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1906"/>
    <dbReference type="EnsemblBacteria" id="AFK07554">
        <property type="protein sequence ID" value="AFK07554"/>
        <property type="gene ID" value="Theba_1906"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1906"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="33556" checksum="DAEFF8FAC6B62CB0" modified="2012-07-11" version="1" precursor="true">MRVRKRLKTIDAIKGWSLSGGYLVYTAIFWGYPFVWLVILALSKWNYFTPRKFIWFDNFIELFQDEMFWRVFFNTFNFMLYFIPMVLGLSLLFALGLKRVKLFRTFFILAFLVANVSSGVAYSIIFQKLFAINGPLNGLTRAIFGITVPWFSSPQLATLSIAIMVTWKFIGYYGLILFSGLQAIPESLYEAAELDGAGKMTKFFRITLPLINPSIVMVLVLSLTLTFGIFTEPFLITGGGPMRTTYTFQMLIYTTAFQKINPGYASTLAIVVALLSYGCVLLTRKLIEREVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L7</accession>
    <name>I2F6L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731372.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1923"/>
    <dbReference type="EnsemblBacteria" id="AFK07570">
        <property type="protein sequence ID" value="AFK07570"/>
        <property type="gene ID" value="Theba_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1923"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752134_0_0_0"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="392" mass="42787" checksum="C46051EB0E4B5388" modified="2012-07-11" version="1" precursor="true">MHNKRLPLLLTSLLVFFVMFGFGLLLQLKLRELGASLLMVGLLTTVRGAVETFGSPAWGAISDGLKKRKLLMILLVLTPAFLYFAYSVIETPIVFILFSSLIAFFTAGFEPIAMALSTEHSRDSVRNTSRELSILNTANSIGMLTGRIMLSILLVFFTVSQAINWYAFVALIAVIPVLFLKEEKHLVSRRKGFLNRLFPLKEDSTPLWENGLWAVYAGTFLRQLGTAGATSIIAIYMTERIGLSGAATAIITSINPFMQIFSHIFFGRVISKTGPRKSTLIGIGLTVFTMVFFAVAKNWVLIAIGYFCLGIAFGAFINGAGTMVSLCSPPGRRAEFLGLLRSARAIGFMVGPLLAGTVAEYSYFGMFIMMASLIATGGLIVIAFTKEQFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L9</accession>
    <name>I2F6L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731374.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1926"/>
    <dbReference type="EnsemblBacteria" id="AFK07572">
        <property type="protein sequence ID" value="AFK07572"/>
        <property type="gene ID" value="Theba_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1926"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_0_1_0"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="256" mass="28733" checksum="EB9C507BFA5C1FEB" modified="2012-07-11" version="1">MRIVFFSDIHGNLEALEAVLKDIESQNIERIYCLGDLVGYGPQPQEVVQRIRDLKIPTIMGNYDDAIGYEKKSCGCAYNPGRETEVGDESLNWSITNTSAAAKEFLRSLPHTLEFEEEGVKFLLVHGSPVDHLLEYIRPDTSSERLQKVLERVKADVVVNGHTHLPMVRWAMGKLVFNDGSVGRPKDGNPKACYLIIDVVQQSISYEFRRVEYDVKSTVEKITEVGLPAELGLVLVLGKGYEMGQSKSKNTIDFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q1</accession>
    <name>I2F6Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1961"/>
    <dbReference type="EnsemblBacteria" id="AFK07604">
        <property type="protein sequence ID" value="AFK07604"/>
        <property type="gene ID" value="Theba_1961"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1961"/>
    <dbReference type="HOGENOM" id="CLU_2789087_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="68" mass="7162" checksum="A2B15D840DBA2452" modified="2012-07-11" version="1" precursor="true">MKALGVVISGTMIKTAVVACSGEISQRKNHATSRDLKNQILTIITEEISSDSVSSIRIGTAGTLFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T4</accession>
    <name>I2F6T4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxiredoxin</fullName>
            <ecNumber evidence="7">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731426.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1994"/>
    <dbReference type="EnsemblBacteria" id="AFK07637">
        <property type="protein sequence ID" value="AFK07637"/>
        <property type="gene ID" value="Theba_1994"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1994"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_4_0"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7 8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-209); in linked form" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="7">
        <location>
            <begin position="203"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-48); in linked form" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="213" mass="24236" checksum="6838DCC2E21212CC" modified="2012-07-11" version="1">MEKRIPLIGEDFPEMKVKTTHGVLSLPEEYKGKWFVLFSHPGDFTPVCTTEFVGFQKRYQKFRELNCELIGLSVDQVFSHIKWAEWIEETLGVKIEFPIIADEMGEVGMTLGLIHPAKGTNTVRAVFIVDPKGKIRAILYYPQELGRNMDEILRMVKGFQVADKNGVAIPADWPNNEIIGDHVIIPPAADVKTAAERKGKEGCYDWWFCHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X3</accession>
    <name>I2F6X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731457.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07676">
        <property type="protein sequence ID" value="AFK07676"/>
        <property type="gene ID" value="Theba_2033"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2033"/>
    <dbReference type="HOGENOM" id="CLU_457706_0_0_0"/>
    <dbReference type="OrthoDB" id="2129865at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="596" mass="68215" checksum="1D70BF1681E278A8" modified="2012-07-11" version="1" precursor="true">MRKIVFVIVLMMVPFVVLGQVEELKAKIAENPLDVESLKALLEIYYENYELENYGTTLKEVIMAVDEIPEAMYPLIEEGIEKLLENAYSDYAEEISEILFDLRPDKNSMLLYLKSLNSGWAMSEEAIRQSVNRLSEDQIEIYEFLHAESVDLYPVDLHLLVSRILVEDFGETDYLIPYIVGLIDDYDFSTARSLLSENSEFLSSSPMYYYLNGILDLEIGYYDDAVEWFLQGKSRDDGTEIYEALSLIEYIYIPEYVTDLFTAIVLANDEASLISNIQEFVLNYEELSWIFSWISRVPEPMKLAEILSDEETAVSYNTVNLDFEKINIGFYDAYASLRGTVSSAIYGQFLDARTYVYISEKMDGVIVEGEREARFDGCDVYSLSPNRDRLLIMDTWGESISMVDSSMDIIWTLSEEYSMVPVAWSPDGSKVVVSTGGDYFSVIDVESGQVIESIESFYDLVFLSLDETYAVDYDGEIVNLTKESLIDTDAPAFWAAYGNNNKIIYFEYPDEYSDFSYDSLHVYDLSTGEDTVIAYNVMFMDAPVPSVKIEGDFVYFTEKDALGMHRVIVMDYITNEVLFESLPSEDIIIFPDVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F752</accession>
    <name>I2F752_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">Theba_2121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731525.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2121"/>
    <dbReference type="EnsemblBacteria" id="AFK07755">
        <property type="protein sequence ID" value="AFK07755"/>
        <property type="gene ID" value="Theba_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2121"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_2_0"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="295"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="327"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="399"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="417" mass="47021" checksum="D9AF47E772CC856F" modified="2012-07-11" version="1">MRKLAVVGAQWGDEGKGKVVNYFSENFEWIVRFSGGANAGHTIFVEDKKYVNHLLPSINPRSCSKGFLGAGMVIDVEQLIDELETLEADFPGISSRFYLDPEAFIVLPWHKEEDLFIEEMREVPIGTTGKGIGPSYTDKVSREGLKLYVLFDESLLKERLEALYHMKRMKYNRDFTLSFGEMTTYLNGLKTKLERLSVNFTSAVDMFRVFRSTSILFEGAQGVLLDLDFGTYPFVTSGACMAHGVSSVGFSTFELDNVYGVLKAYTTRVGSGPFPTEEFSEVGNLVRERGKEYGATTGRARRVGWLDLPALRYARIRSGLTGFVITKGDVLNGLDEVKVCVAYDVEGAVKEMPSTSYDFFKARPIYETISGWPSTDHINFLKYMTFIERETGVEIDYISYGPRTEEMKTRNDLIMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B7</accession>
    <name>I2F7B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731584.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2187"/>
    <dbReference type="EnsemblBacteria" id="AFK07820">
        <property type="protein sequence ID" value="AFK07820"/>
        <property type="gene ID" value="Theba_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2187"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="34700" checksum="991EF6E171ECA2B5" modified="2012-07-11" version="1" precursor="true">MFVYLKKLFAMILTVLLVLLITFVTFEIIPGNPALSRLGVDAQESQYEALSAELGLDDPLGIRLSRWLKGLFTGDLGISMRYSVPVSELILDRLPVTISLAVMALALIILIGIPLGIVSAKYGERLPGVMITLISQIGMAIPSFWSGIILIYIFGILLRWVSPGGYVPWSEDAYGAFKSLILPAIAIALPSIASVIRYTRNSVMDQMKNDYVRLAMSKGMNLNSVLLRHVLKNALIPIITVLGMITANILGGSIVIEQVFTLPGVGRLLINAITTRDLPLVQGMVLYIAFIVVIINFFIDVIYTVIDPRIRLGQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C6</accession>
    <name>I2F7C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="7" type="ORF">Theba_2196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731592.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2196"/>
    <dbReference type="EnsemblBacteria" id="AFK07829">
        <property type="protein sequence ID" value="AFK07829"/>
        <property type="gene ID" value="Theba_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2196"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="208"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="419"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="598" mass="66999" checksum="11E8BD7F83C2E309" modified="2012-07-11" version="1">MRIHELPTDVVRKIAAGEVVTGCFSVVKELVENSIDAGASLVEIEIRSGGKEYIMVRDNGSGMTNQEAKLAIKPHTTSKISSIEDLDSLITFGFRGEALSTIASVSRMRLSTAADSEELGTILEIAGGSVTGQKPLSGSNGTFVEVFDLLYNTPARRKFLKSASIEGRMVTEMIQRFILAFENVDFVYSRDSQTVFDTRGAGSLQDRIALIYPGISTRDLIPVSGDSGEIKVNGYVTLPSRTRKNRMGENIFVNRRYVRQFELNYALERGYGETLQKGNFPFAVLFIDIDPQEVDVNIHPQKLEVKFASTAAVLDEVKRAVRSAIKGAGHFTINIVHSEENITGSSEERKDVSEIYQDHEVSNHGFKHPWRNQKVFDNNASDTYTQSRIDRHHFRSFALGGEREGSPEKEKSGEGKVSFIGVFGERYLIAESEDGLLLIDQHAAHERIIFETLKESKRIAPQNLLMPLELNLERSRMDLVIAREETLKKLGFTFDFVNDKIIMVSIPQVMGVEGVVDVLEEILDEMRLEGLEDPKTVFDNLLASIACKAAIRTGNRLDIGQAEELFEELRRKNLLVCPHGRPISMVIRLEDLDRYFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D0</accession>
    <name>I2F7D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487688.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2200"/>
    <dbReference type="EnsemblBacteria" id="AFK07833">
        <property type="protein sequence ID" value="AFK07833"/>
        <property type="gene ID" value="Theba_2200"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2200"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_2_1_0"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="284" mass="31041" checksum="FCC8688DCE85458E" modified="2012-07-11" version="1" precursor="true">MKKISETGIRIVTAAVVAPFVILCFVNYYSFIGLVSAVVLFSNYEYLKFSLKERNHQSVRIALSGVIPAIIVAYGILLDRFARVESAAPRPELIFAVGVISITSIVITTVADVRSAKEIIANSVFSLIYIGFDLAFFYHIYLGFGSSMALMSLTSVWLFDTGAYFLGKKFGHIRISPSYSPKKSLEGVIGGYVTSLLFMLLFVSLSKLTGLYNGPDLGILQFMVLAVVVAVFGTIGDIAESSFKRYHGVKDSGSLLPGHGGMLDRIDGVLFVTPMFYIFLTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J9</accession>
    <name>I2F7J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07902">
        <property type="protein sequence ID" value="AFK07902"/>
        <property type="gene ID" value="Theba_2273"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2273"/>
    <dbReference type="HOGENOM" id="CLU_2880669_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="63" mass="7664" checksum="FE90CFA784ED50B0" modified="2012-07-11" version="1">MLLRRRQQNARSQSEERKAALVLTLRVQVLLRTLEKKRGETEETRDFRPIMELRNKMIELQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L0</accession>
    <name>I2F7L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487576.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2285"/>
    <dbReference type="EnsemblBacteria" id="AFK07913">
        <property type="protein sequence ID" value="AFK07913"/>
        <property type="gene ID" value="Theba_2285"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2285"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="73"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="549" mass="62517" checksum="088A1DC3E3559CC7" modified="2012-07-11" version="1" precursor="true">MKRVLVILIVVFLVTSTVMFAADIKRGGTLRITSMKQGILIENFNPFSPNSNEMAIGGFYETLIYFNPMTGKIMNWLAESYEWSDDLLELTFNLREGVEWNDGTPFTEKDVLFTVNLGKNNKALDVASLWSTGVVGVRSDKPMTVTFTFSDVNTTIIQRFSSVFIVPEHIWSKVDDPLTWIGEGIPVGTGPFVLKEGSFSEQSFSVVRNPNYWQIGEDGKPLPYIDEVLTLTTTNEQVPLRLARGEFDWAGYFVANIDEVFVKADPEHFKYWLPEGNLVFLNLNNLKWPFDNYNMRAAIAAAIDPVEITRIMASGAVPASLAGVKASYLRLAEKGLNEYGIEYDPDYARYLIEKEGYKLNRNGIYEKDGKSLSLNLYVPTGWTDWIMGAEEVSRQLKEIGIEAIVTLAAWPSPYKDMMYNGNYEMLFGIAVTGTSPYYQFDNWVHSKHWAPIGENAGNYYGMRYKNERIDELLDSYKRLTDPEAQDAVMEEVLTIFLRDLPSVPMFFNPVWFEYSTRNFVGWPNAENPYAEPRPTGMDKMPILLSIHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M0</accession>
    <name>I2F7M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731678.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2295"/>
    <dbReference type="EnsemblBacteria" id="AFK07923">
        <property type="protein sequence ID" value="AFK07923"/>
        <property type="gene ID" value="Theba_2295"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2295"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_0"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="310"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="455" mass="53863" checksum="260C092CE5C13AE9" modified="2012-07-11" version="1">MFVGRKRELAYLEERFKTGKPELIILYGRRRVGKTELTKEFLRKKRGIYYLAEKLPENLQLKKLSEKVIEFFDEDIITEFSNWEMLFKYLASKHDRYILVIDEFPYLIEREPGIISSFQKGWDEYLSNSNVFLILTGSSVSVMENSVLGYKSPLYGRRTGQLLLKQFPFNEIGEFFEKKYGFDDLLKIWGTLGGVPFYLEQFDSDLDYYGNVMEKIYNQNEVLFAEAEFLLNDELREPRNYFAILRAISLGKRKLGEIINETGIDKSSIMKYISILNLLGIVEKEVPVGEDPLKSKKGLYRIADNFFRFYFRYVFYYKDLILTDQRERLLSILKDTENQFFALTYEDFARSAVMWISGSNYFEIGRWWDRNAEIDLVGMNREEKRILLGEVKWSERPVTTDIFAALREKAYLPRWDEFKEKEYAIFSRSGFTKALVDEAKSDRSLMLFHGDKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R9</accession>
    <name>I2F7R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07972.1"/>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07972">
        <property type="protein sequence ID" value="AFK07972"/>
        <property type="gene ID" value="Theba_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2347"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_5_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
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    </dbReference>
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        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
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    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="224"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="297"/>
            <end position="349"/>
        </location>
    </feature>
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            <begin position="346"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="653"/>
            <end position="784"/>
        </location>
    </feature>
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        <location>
            <begin position="776"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="964" mass="109416" checksum="E383420C9AC28D7D" modified="2012-07-11" version="1" precursor="true">MKNRLISLFLAAIATVFAAVIIFAMTEVRYSKIENHIANSARIITENNAKTAFLGYFHWDSMYEALESGDADFVIYNLEDLLKNNSLIEGVVVVYRNEEFVSAGESFQTLRDHTIGASAFYEIIPSGEDLLATMRVTDSAGLESLKDSYAILKLNLDEILRLLTTEDYRLSSVEGTSVFEGISLSIIRKWSPANYATVSLVFLMSLSFTMIVQRLEGKRSIASKNNEMLLLLNHIPTLIWYFKDSETFGIVNKSFAEFFGMRPEDIEGRKIREIFSGEDLSTSIETNKLVFAGKEEHIYEQDTRNSKGELRTLIVTKTPEIDENGNIKSVVCSACDVTDERKALRRIELIQFGLDNANDEAFWIAPDGSILYANSAACKSLGYSREEITAMKVNDLDKSLEADDRKSSWERLKSNGKDNFEAYHLRKDGSTFPVEINRNYFKYDGREYEFTFARDISDRLKSFEILERDKFRIERLHEAALNLERCSELQSVYDLVIEAAKEILEFDICFICVREEENLVIKASSNLNPRDPLEMSIDKGIVGRTYREKKSYVIDDIQEFPGALRTNDIYRAGLSVPVGDVGVFQAMSVKKAIFGEQELRLAELLMSHAREAIVRIETEKRMNYMSLHDKLTDLYNRLYFEEELKRLEGSRFYPISIVSADIDGLKLINDTMGHSRGDQILIELSQILRSCFRKTDVVARFGGDEFAIILIKTDEEITEKIALRVRKIVEKFNMNNSGPPLSVSMGIATSNGPEQELVETLKQADDLMYRDKLYRSSSVRSQMVNTLLVTLAEKDQISGGHAKRLQKLCLELGRRARLSTRQLSDLALFAQVHDLGKVGIPDSILFKPGPLTADEWRIMKLHPEKGYRIAISSPDLSSVADLILKHHERWDGRGYPLGISGEDIPIECRILSIVDAFDAMTNDRPYSRAISKEEAVEEIVNCSGTQFDPKLVQMFKSIVSNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z2</accession>
    <name>I2F7Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose-5-phosphate 4-epimerase-like epimerase or aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731783.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2430"/>
    <dbReference type="EnsemblBacteria" id="AFK08045">
        <property type="protein sequence ID" value="AFK08045"/>
        <property type="gene ID" value="Theba_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2430"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_1_0"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="23378" checksum="1762F44F0E31BC6F" modified="2012-07-11" version="1">MNRDEFASLVLDACKRMEDRDMTVGTWGNISVRVDDETFLITPSGMSYGSLKIDDIVMADMKGNTIDNKRKPSIEHALHRMIYSHRPDVGAVIHTHPQYSTAFAIARKDIPAVSEELVQIIGEGVKCAEYALPGTEELAANVVSALGYNNAALLANHGAVCVGSNLSDAFKVAEVLEKSAKTIIMATIIGTPKVISHDECLKMQDFVKNHYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F829</accession>
    <name>I2F829_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731814.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2471"/>
    <dbReference type="EnsemblBacteria" id="AFK08082">
        <property type="protein sequence ID" value="AFK08082"/>
        <property type="gene ID" value="Theba_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2471"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_0"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="277" mass="31023" checksum="1AB3AAC3C564A877" modified="2012-07-11" version="1" precursor="true">MNDVIQTIIEWAIRIGISIAILLVAKWLSGIFYKAFIKFTEKTSVVSIQYRKTMRTLFNLAFYALAAFIIISVLFKNLAPVLAGLGVSGIIVGLAVKEPLENLICGILIMINKLIYEGEAVDIGGTSGGVQEIKLNHVLIKTWDGKLVTIPSKNVWAATIIHFWPDNIRRNDLNVGVSYSSDLNKVMKILEEAVNSYEKLYVDDNHKPMIQFTGYGASSIDFVVRFWVEKANFIDSSTELAKIIKSRFDENGIEIPFSQLDLHIKDGHTEGRNEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F842</accession>
    <name>I2F842_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731827.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2484"/>
    <dbReference type="EnsemblBacteria" id="AFK08095">
        <property type="protein sequence ID" value="AFK08095"/>
        <property type="gene ID" value="Theba_2484"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2484"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395770_0_0_0"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="10"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="696" mass="79437" checksum="A9A06A3638E7B249" modified="2012-07-11" version="1">MKRVECRDGKFVIDGRERFLFSAEMHYFRVPAGDWFDRLEKIRRAGFDTLSFYVPWFWHETKEGETDFEGRTSPERDLTGFTRLAMEYGFDLIIKPGPYIMSELKNEGLPDWLYMKHPDGIALTSEGKPHPTRVFSYLHPGFLDCVRKWYASIAKAIRESDAIMIQLDNEVGMLHWVTSTGDYSPVALAHFREYLTARAPELLAELEAWSYGKQFGFPLNVEYHRFMRQYFREYLETLSRFMDEECIDLPKIINIHGFDTLEYAKRGKNYPIGVSQLKAAADIPRAVLSGDYYIGNIVHENFTDISISNSIMTAVENPAQPLFSAEFQSGFQHDRPKLMPSSIDLSSLLCIAGGMNAINYYLFVGGRNPEGSGLMGSAHDWQAPIGASGELRGSYNKIKELISTVRPSEKELLNAKPAFDTWFGFISSYYAGEFFAQDGYPFARTKAHRDMATFDGLLRGLFLLNYTAGAVDLEAVEEIDPTKRPILWVFSGPFMPAGVQKKLVRYMESGGRLVLFPALPEREEHGRECAIIRDRLNVEKGKERDWSMARIFGLEINAFYTESYRELSGLSPFGFDEEGSACAFYGSVGQGEIVMLGCGIELEREYKLEVLRRLCEHLGIERNVEIKGEFIDAWLRKGEGVDFLFLNNYDDYDKTITVKTGDLEFEATVKGRAGLIVRLDGSFRERKKFEARKAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L0</accession>
    <name>I2F8L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type metal ion transport system, periplasmic component/surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731961.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2664"/>
    <dbReference type="EnsemblBacteria" id="AFK08263">
        <property type="protein sequence ID" value="AFK08263"/>
        <property type="gene ID" value="Theba_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2664"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067080_0_0_0"/>
    <dbReference type="OrthoDB" id="1230456at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="259" mass="28534" checksum="F4D6B4A9D564711C" modified="2012-07-11" version="1" precursor="true">MKRLFVLLVLLGVVFAFGTTKIRIGASPVPHAEILEAIKADLAEKGFDLEIVVFNDYVLPNIALSTGELDANYFQHLPYLVSFTSQRGIKGLVSAKAIHVEPMGFFLKKPLSELVPGDKIALPNDPTNEGRALILLHNNGLIQLKDPTKLESTVLDIKENPKQLTFVEIEAGFIPRVYTDDKTVVGAVINTNYALTINLNAVTDAEFIEGAESPYANIIAIREVDKDEAWLKALIDALTTEKVRDFINEKYDGAVVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L4</accession>
    <name>I2F8L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein with PD1-like DNA-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731963.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2668"/>
    <dbReference type="EnsemblBacteria" id="AFK08267">
        <property type="protein sequence ID" value="AFK08267"/>
        <property type="gene ID" value="Theba_2668"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2668"/>
    <dbReference type="eggNOG" id="COG1661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114051_2_3_0"/>
    <dbReference type="OrthoDB" id="1752865at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="141" mass="15462" checksum="9EDA6759BF826832" modified="2012-07-11" version="1">MIFGRDESVLLFRFEDGEDFIDTFVRTLSDNGLHSLIVVSGIGMLRDFTIGWFNSVSKQYEKELVTVPHELLHISGNVSLKGGKPFPHLHVTLSGPSRSAVGGHLFGGTVCNTTELFAITTGDLRLIRDVSGAATPLEFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E0HXR7</accession>
    <name>E0HXR7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0863</name>
        <name evidence="9" type="ORF">Theba_1110</name>
        <name evidence="10" type="ORF">Theba_1134</name>
        <name evidence="11" type="ORF">Theba_1686</name>
        <name evidence="12" type="ORF">Theba_1708</name>
        <name evidence="13" type="ORF">Theba_1753</name>
        <name evidence="14" type="ORF">Theba_2321</name>
    </gene>
    <organism evidence="9 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
            <strain evidence="9">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730611.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06573">
        <property type="protein sequence ID" value="AFK06573"/>
        <property type="gene ID" value="Theba_0863"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06815">
        <property type="protein sequence ID" value="AFK06815"/>
        <property type="gene ID" value="Theba_1110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06838">
        <property type="protein sequence ID" value="AFK06838"/>
        <property type="gene ID" value="Theba_1134"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07346">
        <property type="protein sequence ID" value="AFK07346"/>
        <property type="gene ID" value="Theba_1686"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07366">
        <property type="protein sequence ID" value="AFK07366"/>
        <property type="gene ID" value="Theba_1708"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07409">
        <property type="protein sequence ID" value="AFK07409"/>
        <property type="gene ID" value="Theba_1753"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07948">
        <property type="protein sequence ID" value="AFK07948"/>
        <property type="gene ID" value="Theba_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0863"/>
    <dbReference type="KEGG" id="mpg:Theba_1110"/>
    <dbReference type="KEGG" id="mpg:Theba_1134"/>
    <dbReference type="KEGG" id="mpg:Theba_1686"/>
    <dbReference type="KEGG" id="mpg:Theba_1708"/>
    <dbReference type="KEGG" id="mpg:Theba_1753"/>
    <dbReference type="KEGG" id="mpg:Theba_2321"/>
    <dbReference type="eggNOG" id="COG3328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036805_2_0_0"/>
    <dbReference type="OrthoDB" id="792870at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK07948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="404" mass="47127" checksum="A67E5ACE0ECD26CF" modified="2010-11-02" version="1">MKFDREKIKSLIEKNGFENVGDVQEAMKELFGDVIKEMLEGELEDELGYSKHDYKNKETDNSRNGHSKKTVRSDYGEIELEIPRDRKGEFEPVVVKKHQRDISGIEDQIISMYARGMTVRDIQSHIEDIYGSRLSAESVSRITDKILPLVSEWRNRPLESAYAIVYMDAVFFRVVESNQVRKKALYIALGVSLNGHKDILGMWISETEGASYWLSILNELKNRGVEDVAIFSIDALSGMEEAIEAVYPFSEVQKCIVHQIRNTMRYVTWRDRRPLARDLKTIYQAPTREAGWNALLALEEKWGDKYHLSIKSWKDNWETLSTFFQYPEELRRLVYTTNPIESVNRQLRKVTKNKGVFPTDNSLLKMAYLAIMNITKKWTVRTLDWSRILTQLVIKYERLAKYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E0HXU1</accession>
    <name>E0HXU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1810"/>
    <dbReference type="EnsemblBacteria" id="AFK07461">
        <property type="protein sequence ID" value="AFK07461"/>
        <property type="gene ID" value="Theba_1810"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1810"/>
    <dbReference type="HOGENOM" id="CLU_2523676_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="84" mass="9563" checksum="C243689DC2FAC578" modified="2010-11-02" version="1">MIGENVLEKRDEEAVTLCGRRAAARLKAENPLNAMKNHPWSFVEHGPVPRNYRCTLMKTTLSVNGFPRRACPSIRSKKLKRSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J0</accession>
    <name>I2F1J0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">Theba_0040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0040"/>
    <dbReference type="EnsemblBacteria" id="AFK05793">
        <property type="protein sequence ID" value="AFK05793"/>
        <property type="gene ID" value="Theba_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0040"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_0"/>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="13"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="45193" checksum="847A8E8F76DC4A90" modified="2012-07-11" version="1">MDLLNKGERVKTASRKLRLLSTNEKNEAIMLISRELEAQKGEILRANSIDVENSRKKGMKESLIDRLALSEERIAMMVKSCENVASLPDPVGEIESAWVQKDGLLISKERVPIGAIGMIYESRPNVTVDASILAIKSGNSVLLKGGSDAINSNKAIVSAIKTALALAGLPDSSVELVEDTSHEAVQEMLKMNQYLSLIIPRGGAGLIKFVVNNSRIPVIETGTGNCHIFVDYNADLNKAVEIVDNAKTQRPGTCNAVETLLVHRDIAAEFIPRVSEVLSKKGVELRGCDESTKYWKMISATDEDFATEFLDLVLAIKVVKDVDEAIMHIEKYSSGHSEAILTNDYANSRKFLKDVDSAAVYVNASTRFTDGGEFGFGSEIGISTQKLHARGPFGLKELTSYKYTILGNNQVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L8</accession>
    <name>I2F1L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490121.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0070"/>
    <dbReference type="EnsemblBacteria" id="AFK05821">
        <property type="protein sequence ID" value="AFK05821"/>
        <property type="gene ID" value="Theba_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0070"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082102_2_0_0"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="88"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="210" mass="22279" checksum="078C39C7C19D70BC" modified="2012-07-11" version="1">MESLEKIRNAIIETMPAEAKVATEEALAEGLSAKEILDGALIPGMDEVGKLFREGEYFVPEVLVAAKAMNQCMDLIEPLLVSGGVKKIGKVVAGTIEGDLHDIGKNLVCMMLKGAGFEIIDLGVDVKPEEFVEAAKGAKPDILVISALLTTTMLNMPRVIEELKKAGIRDNVKVLIGGAPVSQTYAEEIGADGYSPDSSAAVELARRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M8</accession>
    <name>I2F1M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730004.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0080"/>
    <dbReference type="EnsemblBacteria" id="AFK05831">
        <property type="protein sequence ID" value="AFK05831"/>
        <property type="gene ID" value="Theba_0080"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0080"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="32393" checksum="5638C46A1139729E" modified="2012-07-11" version="1" precursor="true">MSKRVQILLFILPGLILVGLFVYGFTAWTFQVSLTNWRDVGSAGDFVGLDNYIRLFSKDRVFKTSLVNTLKLTLVFIGVTIPLGLFLAVLLDLNLKGKQLFRLIFLLPLSFSFVASASMWTWMFSPEIGSVNALLRAIGLDSLTQPWITSDKQALICIAIAYVWQFSGFSTLVYYAGISGVAPEITEAAKIDGASTFQRYMKVIIPMQRPATLTVLMILLMYSLRVFDLVWLMTGGGPGSSTEILSTFMFRTAFNRNRFGYGAAVGVVMFAISILIVIPFFARLRRSEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N7</accession>
    <name>I2F1N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730011.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0091"/>
    <dbReference type="EnsemblBacteria" id="AFK05840">
        <property type="protein sequence ID" value="AFK05840"/>
        <property type="gene ID" value="Theba_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0091"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_7_0"/>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="249" mass="28519" checksum="F76E76DB76D8C85B" modified="2012-07-11" version="1">MRIGGVPLNIVWESPEINMKIIERVFAGASEAGVELIVFPETTLSGFTNNAERAYVKDACGFFRKQVDHWGIPAVYGFIDRRNSKFYNCAAFLAPGSEPLIYRKRKLFSYGGENIVYSPGDTNLSFEMKNIHFSLNICYDLRFPELFRANLPAEVMIVIANWPEKRANHWQALLKARAIENQSFVLGLNRTGVDGNGIEYDEAFSVLFDQDGNEVPFEAEKGLLLWELDYEKMSILRDWRERFPALKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P1</accession>
    <name>I2F1P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730014.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0095"/>
    <dbReference type="EnsemblBacteria" id="AFK05844">
        <property type="protein sequence ID" value="AFK05844"/>
        <property type="gene ID" value="Theba_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0095"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="107" mass="11658" checksum="D99E6C8377F8C1CC" modified="2012-07-11" version="1">MKLVKSSIEKGKVALDRPGLKGRIIYDRENAQAVVIDIAEGMELAEHKTPVDVFILVLAGRGIITIGGDKHEVMEDDIIDSPKMIPHGIVNTGEETLRVLVVKAPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q3</accession>
    <name>I2F1Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0107"/>
    <dbReference type="EnsemblBacteria" id="AFK05856">
        <property type="protein sequence ID" value="AFK05856"/>
        <property type="gene ID" value="Theba_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0107"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="236" mass="27190" checksum="BFEEC2685A0C180D" modified="2012-07-11" version="1" precursor="true">MFVLAHRGMGKGRYENTLRSFKEGLSYGAHGVELDVRLTKDGVVILNHDPDLKRTMGLDVKISEKTFAELEEMGLVGFDALTTLEEIYRELPEDIFVDVEIKAVEAVPEVIKIVKRFDALERTMFSSFHHDCLHEFKEELCCPMVAPIIDKELLRPGGEEFLYKVIERYRPYSVNLNKDLFENIGLEKGLSLLRKIREEGTRVALWTLNDSDLFLKVRDVCDFLITDRSDVMMEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T3</accession>
    <name>I2F1T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0140"/>
    <dbReference type="EnsemblBacteria" id="AFK05886">
        <property type="protein sequence ID" value="AFK05886"/>
        <property type="gene ID" value="Theba_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0140"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116293_1_0_0"/>
    <dbReference type="OrthoDB" id="1792346at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016541">
        <property type="entry name" value="UCP008505"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14367">
        <property type="entry name" value="DUF4411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008505">
        <property type="entry name" value="UCP008505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="162" mass="18627" checksum="91035871B9318977" modified="2012-07-11" version="1">MSKENANSQVYVIDTSSILDWLKRYYSSDVFPALWDKVHDLIAEERLIAPYEVYKEIQVGGDEIAKWASKHEEMFIEPSNSEQSFVGDMISNSKVTTPKKTKSGLWADPWVVAMAKEKEAIVITGEQARNVFPASRIPDVCKLYKIRCGTFLELMRLEKWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X5</accession>
    <name>I2F1X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730092.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0188"/>
    <dbReference type="EnsemblBacteria" id="AFK05928">
        <property type="protein sequence ID" value="AFK05928"/>
        <property type="gene ID" value="Theba_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0188"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="284" mass="31559" checksum="FBD59DD3746DEB6F" modified="2012-07-11" version="1" precursor="true">MLDEAIKVKNLRKTYGNFEAVKGINLSLVPGKVNALLGPNGAGKTTTLKSILGLVHYSGEITILGEKIDVARERISFVPEDKSFYDSLTPEKAIKMCSMLMGNFSAEKAAKQMKDFDLPINKKISAFSHGMKTSTYLAIAMAQDADIFIFDEPTWGLDPLRRDEVLEMISALSERGKTVLYTSHIIPEVEKIADVFSIMYKGVILYTGEMKGLDGRFALYSLPLRTAIDKNDFTAVVKEANVLKVLTDNPKEIARLKEIEGSKREEVNLESFFGTIVRGNKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y9</accession>
    <name>I2F1Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein, putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730105.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0207"/>
    <dbReference type="EnsemblBacteria" id="AFK05942">
        <property type="protein sequence ID" value="AFK05942"/>
        <property type="gene ID" value="Theba_0207"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0207"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_1_0"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="154" mass="17649" checksum="02362112D796672D" modified="2012-07-11" version="1">MGFTLKSSYALRALYKMAKSTREGKDKLSLVEIVQGNEIPRDFLEKIFGELRQAGIIKAVRGRYGGYCLARPANEILLRDVILKLDKPMNSYPCLQQNGKCLEDPNCTVKYVWFKLYNAMMRELGSMTLENLLEYGDKIAQNPLESNEMKENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z2</accession>
    <name>I2F1Z2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730108.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0210"/>
    <dbReference type="EnsemblBacteria" id="AFK05945">
        <property type="protein sequence ID" value="AFK05945"/>
        <property type="gene ID" value="Theba_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0210"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_0_0"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="33"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="30873" checksum="270CDF0F6DCAACCF" modified="2012-07-11" version="1">MSISLLQEELRDYVENVKRAARFIEKEVDLQPKVAVILGSGLGDVSKSLENAVSIPYDEIPGFPLSTAPGHKGELIFGNALHHSVMLMNGRFHFYEGYSMRTVTFPIRIMQELGVEVLLITNASGGLNPDFEVGRVMLIRDIINFMGDNPLIGQNVDEWGPRFPDMSEPVDRDLLSKALLSAKELGIGVYEGVYVGVAGPNFETPAELRMLRRFGADAVGMSTVPEVIVARHAGIRVLGLSAISDRAVAEDLKPLTAEEVLEMAKKAGNDISKLILKTLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F232</accession>
    <name>I2F232_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730145.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0251"/>
    <dbReference type="EnsemblBacteria" id="AFK05985">
        <property type="protein sequence ID" value="AFK05985"/>
        <property type="gene ID" value="Theba_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0251"/>
    <dbReference type="eggNOG" id="ENOG502ZASC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605216_0_0_0"/>
    <dbReference type="OrthoDB" id="310145at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026950">
        <property type="entry name" value="Caps_assemb_Wzi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14052">
        <property type="entry name" value="Caps_assemb_Wzi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658472" evidence="1">
        <location>
            <begin position="22"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="543" mass="61678" checksum="A49941E75C3DA19A" modified="2012-07-11" version="1" precursor="true">MKKFTLLLFFTLLATVFGSQGTLMFKGTDQYNLFLGRNLVDGRTLFTANTAIPEGFASVQSEQPTVKTAAGTDVFLRVTPQFMIHNFEPFKQKGWLQSVVPLYLRYRYDTLKPWLVLGFESEVSDNITGFINLDIPKDYRSYISHGDNFDSKPYMNFPVELFEGKLEALDMSWPTLGYVSYSSDNFYASLGRYKVAWGPMRNGLTISDASSYYDNVSSSYTTPLWKSGHFTYSFLVITPTSLLNDEEWVKQGKVWDLNQRRPYTEGAKTIIGHRFDVQFSTWGRFGVGELNVVGGKHPDLNDANPFIIFHNTYGEDFSNVMASLDLSLVPFKGIELYGEIAIDDVSFGSTEAGARGKPTALAYGGGFRYAVDIKGTLLLASVEFYHTDTWMYNRWQPFLTFTNRIYTKSELPGSRDFTDYPLGFKYGPDLNGFSIMANAIMTNGLSISFVYEYFKQGEVTLKTPYLNMEEPEDDPGEFTAPEDWGGPVGETVNANILKLNAMIPYRDFTFGSDFSLYFGDYFKKNGGYERPIFEIRPYMSYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F274</accession>
    <name>I2F274_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491767.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0296"/>
    <dbReference type="EnsemblBacteria" id="AFK06027">
        <property type="protein sequence ID" value="AFK06027"/>
        <property type="gene ID" value="Theba_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0296"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_0_0"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="36459" checksum="63F91663D8D4CDB8" modified="2012-07-11" version="1">MIRKITSIVSCIQKANDILVVGHIMPDGDCISSVVSLSMGLEKFGKKVTPAIDWKIPANFTVFPWIDRIKDFSNDVVEPNLIIIVDASSPDRIGRFEQLLRKGIPSVVIDHHATNTYFADDCWVDPSYSSAAQMVLDLLKLMDVEYDADLALMNYIGIATDTGFFRYSNVDSSVFEAAAELVRLGADPTFVATSILETRKIEELFLERDAIDNIKMLSNGRFAYSYLELEDFEKYSLTEDDFVGFVGDLRSIKSVEVALFASEASKGEAHVSLRSKSYFDVSKIAVAFGGGGHQKASGFTLRYDGNLEDALAETIEMIDSQLQQKEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B0</accession>
    <name>I2F2B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type transport system involved in Fe-S cluster assembly, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730204.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0334"/>
    <dbReference type="EnsemblBacteria" id="AFK06063">
        <property type="protein sequence ID" value="AFK06063"/>
        <property type="gene ID" value="Theba_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0334"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="245" mass="27377" checksum="788E2F723073532B" modified="2012-07-11" version="1">MLEVKGIKLVRDEREILNTLTATFESGRVYAILGNNGVGKSTLSYVLMGLESHRDYEGNVVFDGEEIDLLSVSERARKGITLGWQEPVRFQGLTVKEYLTLGGKLKLSKEELNETLSVVGLNNEYLDRFVDESLSGGERKRVELASIILISPKVTILDEPDSGIDIMSMEMIERVLERLSDKGSIVIIITHREEIARMADEAFLLCGGRILASGEPEEIVNFYRKLCDNCQHINEPITEGGQIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N3</accession>
    <name>I2F2N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglycosylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730300.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0460"/>
    <dbReference type="EnsemblBacteria" id="AFK06186">
        <property type="protein sequence ID" value="AFK06186"/>
        <property type="gene ID" value="Theba_0460"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0460"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1018559_0_0_0"/>
    <dbReference type="OrthoDB" id="1888649at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="178"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="270" mass="30835" checksum="B1EB29A1B3ED079B" modified="2012-07-11" version="1" precursor="true">MDKGKKIDMIVLSILLASIIIFSLILTSLSAKNRLDRVAALSVLYNAGLGADYKSILESPSYQYDDRVVEAYRYFTDKSGSLNYRLSSSVKMHNVSENDLFVCNQTISDLSQQNAKRKCPYLETKIASLIESSSLLSDRSAIFKNRLSEEIYNALMEFANVKVDIIVGGEIKTLDLSRLDPEVVLSIMVVESSLNPFALMEERSIDESFSDYVHSRGLMQIYEMTLWTLNSWLKQSRINIKPQELWSIRNNIFLGMVYLAYANEFLEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T3</accession>
    <name>I2F2T3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">minC</name>
        <name evidence="6" type="ORF">Theba_0513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730343.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0513"/>
    <dbReference type="EnsemblBacteria" id="AFK06236">
        <property type="protein sequence ID" value="AFK06236"/>
        <property type="gene ID" value="Theba_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0513"/>
    <dbReference type="eggNOG" id="COG0850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048711_2_1_0"/>
    <dbReference type="OrthoDB" id="1665744at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01222">
        <property type="entry name" value="minC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <feature type="domain" description="MinC_C" evidence="5">
        <location>
            <begin position="108"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="218" mass="23992" checksum="AEEECB99643CF742" modified="2012-07-11" version="1">MPIDFRMTKKGLILLIDSYRSVDELRQDIMKKFADAKDFFSEGDEISLMLTQETSKPDDIVKIVSLLSDLGVHVKDILVGSMEQKDVKVGQKYDLVREKITEVRGAQIIRRNLRSGQIVVHNFDVVVIGNVHPGAEIIAGGSVVIFGSAKGVLRAGYSQGETGVIAAIDLQPSLIQIGNFITQEYDHFDGPAVAHVRTGRIIVEEADNVKFEVKGEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V4</accession>
    <name>I2F2V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deacetylase, histone deacetylase/acetoin utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730364.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0534"/>
    <dbReference type="EnsemblBacteria" id="AFK06257">
        <property type="protein sequence ID" value="AFK06257"/>
        <property type="gene ID" value="Theba_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0534"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_3_0"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="320" mass="35919" checksum="FA04E154523FE391" modified="2012-07-11" version="1">MIVFYDRRHLFHLPMKELDNGNWIENPDRPERIESVRSALESAGFQIKEPRDYHCSHLFQVHTPEYVEWLKAKSNSVSRDREYFPEVFGYDKLFDTGTPVTSGCYVSALASVSTALNAVDSILESEPVSYALCRPPGHHAGKSTGGGYCYFNNAAIAAKYYQKHTRGYVAILDLDFHHGNGTQEIFYYDDTVFYVSIHGDPKNFYPWISGNSWEIGSDTGEGFNMNFPLAGGIEGPEYMRTLSKALQEIEDFSPDLMIISLGTDGHKDDGIGHFNLSSEDYSMMGKLIGEIEVQKLIVQEGGYNPNANSASVLNFLTSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X3</accession>
    <name>I2F2X3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Acyl carrier protein</fullName>
            <shortName evidence="8">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpP</name>
        <name evidence="12" type="ORF">Theba_0553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8 10">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0553"/>
    <dbReference type="EnsemblBacteria" id="AFK06276">
        <property type="protein sequence ID" value="AFK06276"/>
        <property type="gene ID" value="Theba_0553"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0553"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_0"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 8 9" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8 9">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="82" mass="9033" checksum="D848A659E1D4FD63" modified="2012-07-11" version="1">MEKTSTIQEKVISVVADCLGMEAGEISGNSRFIEDLGADSLDLVDLVMELEDKFEVQISDSQASSFRTIDDVVKFISTLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y3</accession>
    <name>I2F2Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0564"/>
    <dbReference type="EnsemblBacteria" id="AFK06286">
        <property type="protein sequence ID" value="AFK06286"/>
        <property type="gene ID" value="Theba_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0564"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="187"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="434" mass="49392" checksum="67C580FFB7590E79" modified="2012-07-11" version="1">MSAYDYWLKPLGLLYISSLLKHIGIQSILIDCLDRYDDELITFSPKFGEKYYGTGKFLESEIPKPRSIASIPRRFKRFGFPEEVLRKKIRQVKNVDCVFVTSMMTYWHYGVHDTIRIIKDEMPSVPVVLGGVYATLLPEHARRYSGADKVCPGTGTEPLKKALGFLGINETLDFDWFDELDPDYSVYKSARYAVLISSLGCPFKCTYCASSLLWNSFVRRDPVKTARFVKHLTASKGLSDIVFFDDAILVGSGFKRLMEEFERVGIKARFHLPNGVHARFVDRETADLMYMNNFKTIRIGLETSDPAMQNSTGGKVNLDDIFVAIENLSAAGFTSREISAYIMVNLPGQSEEDVLTSLRICEELRISPSLNEFTPIPGTVQWKELTSGGVFDEDIDPLLLDNSILPYWWKEGFSPEAVQRLKEKAWSLRRRLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F314</accession>
    <name>I2F314_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0598"/>
    <dbReference type="EnsemblBacteria" id="AFK06317">
        <property type="protein sequence ID" value="AFK06317"/>
        <property type="gene ID" value="Theba_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0598"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489010_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="367"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="557" mass="61883" checksum="61977ABC14A9E5A0" modified="2012-07-11" version="1">MEDSAQFCLDLIDEAVVVVNKNGRVVFQNSVSQKHFGDLIGKLYKAFFDCEDIFVDDEGVVWRVSSSSDKSDSNEIKIFRRTNSLSIGSSFTKREKTSASSFFQGIDDHSTLHSMHSNTSFSILSEIDHFRVYKKAFEENTSGMAIFTVDMSREKIIPAAKNLAFEINRLARLPVIEGIPLDRPMSKADHLFLKALIRVARTGRQEALFLSEEGFYEEVLIKPLSDRDLISVHKEVSAEMNLRMELLSARYLAGTIDQAVISVDENGKIVFVNKAAEILLGRERGGLIGKNINYFLENQSDSRSEKPSAGQEIGERHLFSINKSNGQSVLVEAAVKRIEDSSLAGKVTATVYCLSGLKFEDVIQESAQKTIRGLIETLSTVVEVRDPFTAGHQRRVSKLATAIATEMGLGPEQIDTVREGALLHDIGKISVPTEILSKPGRLTENEWFLIQSHSEAGFKMLERIDLPWPISSIVRKHHERLDGSGYPHGLKGKDIPFETRIVTVADVFEAIVSHRPYRPAHETSTAITELTEGAGRLYDGDVVDCCLSLVGKGFSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F367</accession>
    <name>I2F367_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730445.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0653"/>
    <dbReference type="EnsemblBacteria" id="AFK06370">
        <property type="protein sequence ID" value="AFK06370"/>
        <property type="gene ID" value="Theba_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0653"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_0"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="385" mass="42682" checksum="573D3E3B3EA2CC02" modified="2012-07-11" version="1" precursor="true">MDLSCFVSSVTPSATLEFNKKALELSKAGENVVKFTAGEPDFPTPRPIVEAAITALNEGKTKYTNASGIDELRKAIATKMLKENGLSYTPDEIVVSNGGKQAIYNVLKALLNVDDEVIIISPAWVSYEAQILLCGGHPVVVPSELDKGFVPEISKIAEVISARTRAIIINSPNNPTGAIYPEHFLRDLAVLSKERDILVISDEVYEKLVYDAEHFSIASIDGMKERTAVINAFSKTYAMTGWRIGYSATSLRLAKAISKIQSHLTSNVNTITQYAALKAFEVDTSSMVKEFRARRDFVFSRLKKIGLRFHKPAGAFYYFIDIRPFLGGRFKNSNDFAIALLEEEKVGMVPGSAFSYEGFIRMSFSSSLEELDEGLNRLENYLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F375</accession>
    <name>I2F375_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein Theba_0661</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730453.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0661"/>
    <dbReference type="EnsemblBacteria" id="AFK06378">
        <property type="protein sequence ID" value="AFK06378"/>
        <property type="gene ID" value="Theba_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0661"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_3_1_0"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="112" mass="13036" checksum="836D4FB6029C012C" modified="2012-07-11" version="1">MSKESGKRYEDLACEYLKENGYRIIARNVAYRFGEIDIVALEGKILVFVEVKGGSSLVLPRYRVDERKIRRLELAAQRYILTEEPKFEEARLDVIEILESGAVNHFRSVGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G6</accession>
    <name>I2F3G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730523.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0754"/>
    <dbReference type="EnsemblBacteria" id="AFK06469">
        <property type="protein sequence ID" value="AFK06469"/>
        <property type="gene ID" value="Theba_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0754"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="30978" checksum="63397DA416596B2B" modified="2012-07-11" version="1" precursor="true">MSKRVGRTVKYVILVVGAIVMVFPFFWSFMTSFKDLKEILRDPFSLIPKEFTMKNYVSVFTKVPFARYLLNSTVVALATTFLQLVTACLAAFAFARMRFRGRDVIFYVFLATMMIPQQVVMIPQYLVVMKLNMDNSYLGLILPHAATAISIFFLRQFFLTIPRDLEDAATIDGCGPLRTLVNVFLPLTKPAIATIAVFSFMWSWNNYFWPLLVISEPEMRTVQLGLAMFKSEGGIQWGEFMAATVVATLPIMIAYFIAQRQFVKGITLTGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I3</accession>
    <name>I2F3I3_9BACT</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0772"/>
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        <property type="protein sequence ID" value="AFK06486"/>
        <property type="gene ID" value="Theba_0772"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
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        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="230" mass="27532" checksum="9F4F5CAEAAF6CFF2" modified="2012-07-11" version="1">MSEKRFEGFSGETLSFLIDLGINNNRSWMERNRDRYRIELLEPFRALVKQLGPSMERIDPFIDVRPQVGKTISRISRDARRNKGKPPYRTNMWFTFRVPGPDWKDSPGFFFELFPDWYRYGMGFYLPSRATMVKLSEEIEKNPVRFVEKTEVLRDSEFSVFGEKYKRRRNRKGVSDSLSEWLQYRDFYIASNHEIDEILLSSRLVGHLEAPFSALSELYEYFWELKMRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J5</accession>
    <name>I2F3J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730552.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0784"/>
    <dbReference type="EnsemblBacteria" id="AFK06498">
        <property type="protein sequence ID" value="AFK06498"/>
        <property type="gene ID" value="Theba_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0784"/>
    <dbReference type="eggNOG" id="ENOG50344FX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193487_0_0_0"/>
    <dbReference type="OrthoDB" id="1980588at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="109" mass="12438" checksum="B0908BE952A6E603" modified="2012-07-11" version="1">MTFSDYINVVLRMIAEGNETHEIYEQLQKLGLREVEITEVYNAVISMITSGSESTEVILDGYYDPRKRVFLDEELKAIISVPGLYKSLLWGDISPGDFERTLSDFSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K8</accession>
    <name>I2F3K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730563.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0797"/>
    <dbReference type="EnsemblBacteria" id="AFK06511">
        <property type="protein sequence ID" value="AFK06511"/>
        <property type="gene ID" value="Theba_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0797"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_0_1_0"/>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="235" mass="27323" checksum="3E3CEBB8A4C4CD10" modified="2012-07-11" version="1">MNPVEYKAETVEEAIRLAQADLGAYDDEMQVTVKEKGSKGFLGIFGSRESIIEVSLLDKHWERKLHDFLKGILKNFDEETFSEVKLVGRTYRVRIEGEEVARLIGKHGKTVAALQHILNIYANRMAPTKVNVTVDIGDYRLERKKLVEEIAHRTAKSAISRRSKIVMEPMFAFERRLVHEVISQYEDLKSYSVGLEPYRKVVVEYRDRKYSYDKAFDSKRRRYENVRTNSGRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L5</accession>
    <name>I2F3L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ORF">Theba_0804</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730570.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0804"/>
    <dbReference type="EnsemblBacteria" id="AFK06518">
        <property type="protein sequence ID" value="AFK06518"/>
        <property type="gene ID" value="Theba_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0804"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_0"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="33"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFK06518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="33256" checksum="BEBE562F69C175A6" modified="2012-07-11" version="1">MAERNLTDYFNSLYLAGADVRLEEPLEWHTTIRIGGPARVFVSPYSVESLSEILSLLKREKLPYKVIGGGSNVICPDKYEGVVVSTRNLNLLRSDGDKVFVQAGTSINSLIWHCLAEGLTGIEFLTGLPGSVGGAVLMNAGAFGGEIGDRVTRVSYLDGRGKVIDVDSRNAGFSYRNSIFKSADGIVVGAEFLLKRGERSEIESKMKEILAKRIQKQPLEYPSAGSVFVRPKSDFYVGSTIERLGLKSLRVGGAEVSEKHAGFIVNRGGACQKDILTLVEIIRKKVEGATGVILNTEIEIWKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P0</accession>
    <name>I2F3P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative NADH:ubiquinone oxidoreductase, subunit RnfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730585.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0829"/>
    <dbReference type="EnsemblBacteria" id="AFK06543">
        <property type="protein sequence ID" value="AFK06543"/>
        <property type="gene ID" value="Theba_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0829"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042020_1_0_0"/>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="307" mass="33417" checksum="7536D2647A5FA4F6" modified="2012-07-11" version="1" precursor="true">MAKKFFLKQPMMRKVIYALLPILIFAVGNFGWVVFSKVFLSILISVFVEWLFEKKKGKPVSEASIVTGFLIGLILPPAVPFWIVIVASSFAMIFAKMAFGGFAKNLYNPALVGRAFVYISFPAAVQQSWTPAVQSWGQGFVRWISSDIITMATPANVIRSGGSVSAWRMIFGNISGSSGETAKWLIAAAAVYLIITKVASWKIIVSTLLSAFVMSGIVYIFDPSKMSPFHWIIGGSILFGAVFMATDPVSAPKKEKSKWIYGAMIGSLAVIIGSFSLFGAGLMFAVLIANTFASLLDYLNTPKKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q2</accession>
    <name>I2F3Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxycytidylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0841"/>
    <dbReference type="EnsemblBacteria" id="AFK06555">
        <property type="protein sequence ID" value="AFK06555"/>
        <property type="gene ID" value="Theba_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0841"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="168" mass="18846" checksum="14F458093FF211AD" modified="2012-07-11" version="1">MMSAEDLSDFLKGFSTHKPESKTESWDSYFMRLAYQVRERSSCHHRKVGALIVRENRILSTGYNQPPSGFPHCDETECIRDALGIPSGQNQEICYAAHAEQNAIAQAAKFGIATNGSTIYVTHRPCSVCARLIINAGIKRVVFSEGYPDPLTEFMFEKTNVTMTQFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U4</accession>
    <name>I2F3U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730635.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0887"/>
    <dbReference type="EnsemblBacteria" id="AFK06597">
        <property type="protein sequence ID" value="AFK06597"/>
        <property type="gene ID" value="Theba_0887"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0887"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143444_0_0_0"/>
    <dbReference type="OrthoDB" id="2043343at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="154" mass="17751" checksum="4D2123D92DB4B3E8" modified="2012-07-11" version="1">MDFEETDLGRIEISEAVIRDIAIHSYIEFLKFDPKEAKARKEAKSTVDIDLDEKVDGTKTVKITVNTKIKYGVSIPSHARKMQEKLKNDVESFSGIKVEDVSITIEDVYEEAQKPAMFEEEEEFENSEVKPELQESKSEETVEETEDEDREKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W2</accession>
    <name>I2F3W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMP synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492612.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0905"/>
    <dbReference type="EnsemblBacteria" id="AFK06615">
        <property type="protein sequence ID" value="AFK06615"/>
        <property type="gene ID" value="Theba_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0905"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098255_0_0_0"/>
    <dbReference type="OrthoDB" id="1242215at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658626" evidence="1">
        <location>
            <begin position="30"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="247" mass="28013" checksum="49584E126ACD67DC" modified="2012-07-11" version="1" precursor="true">MKEKTVIQKVGAAIMFLLAICFPASFVSASENCGPVALFLNDPAYETKLSPIERSLAEQGIEYRIYNIFNDELPQDENLYSAVIIAGGDSMRNYIDWNNRIYQGGEIILRGEVPILGICLGHQIISRVFGSVLYYSEERRWHEITFVKQDEIFDGFEDGLLVWENHSYAVASLPEEFEILAKGNVTPLQMMKHKDKPIYGVQFHPETQGRFLSNPPGWKLIMNFAKIAGVTMSDPPLPKDGRKVFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y2</accession>
    <name>I2F3Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maltose-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730658.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0929"/>
    <dbReference type="EnsemblBacteria" id="AFK06635">
        <property type="protein sequence ID" value="AFK06635"/>
        <property type="gene ID" value="Theba_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0929"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733144_0_0_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="367" mass="40915" checksum="83F648B73C7D80CE" modified="2012-07-11" version="1" precursor="true">MKRLFLSVLVILVCSAVFGITFWVSWEGEKFYRDAAAAFKEETGIDVEIVYFPKIEEKLNINLKTGYLPDAAMIKDTYVGDVAASGRSLSLNLASLTGYSQKFLNAYVWNGEITAVPFYADCQVAFVNLNAFEEAGIVLGEKLDFDQFEAIKESLTGVVDYPIAFDFTSPYVMFPYVSALMSQEELYELNIGASGSREIVSKIKEYFDNGVISRLERAAMNKLFAQGKIGIMLQGSYMASKFREKGPDFVMLPFPNIEGVEVRGIIDSKGFALFNSDTCEQCMSFIGFLNEHSHDFFVEYDKYPLFGSDSPQELESVVNQGKFMPNLPGYQSLLFEALEPALQAIYSGAMTVDQALSGAQSYIDSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z7</accession>
    <name>I2F3Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730671.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0944"/>
    <dbReference type="EnsemblBacteria" id="AFK06650">
        <property type="protein sequence ID" value="AFK06650"/>
        <property type="gene ID" value="Theba_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0944"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_6_1_0"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="189"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="376" mass="41291" checksum="4EED0063E440155A" modified="2012-07-11" version="1" precursor="true">MNLSILFFEALIYASLATKNLLSQYFDISGFSSTEIGILMAVLPVVSLVSSPLWFKISSGLGQNRIYYIVSLSSAVCIWPIFAASDFLTSLLFMILFSLFFSAVVPLGDSIIMTSIKKTGGRFDRVRLFGTIGFAATSLLLSTVVGISFFWLFAATSVVLAFSPIFLKKKSDASRTEATESSAGAGSLLQFSMMTIGMFFGITLNSFHNSFIAVFTRQNGMDPSVVGIVFAITALSEIPFLLVADRIIERIGSMKILLFGMAVIGVRMILVSFATNVYALYLVESLHGLTYILMYYSLFHFIHYGLSGRQQIFAQSVFWIVRSGLTFIVGSIGGGIIIDAFSVFFAFRFFGYVGLLSAIIMTIVYLSFRRSRSNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F405</accession>
    <name>I2F405_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">Theba_0952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730679.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0952"/>
    <dbReference type="EnsemblBacteria" id="AFK06658">
        <property type="protein sequence ID" value="AFK06658"/>
        <property type="gene ID" value="Theba_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0952"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_2_0"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="9203" checksum="7639F8335DB51E85" modified="2012-07-11" version="1">MVRDNRRRGRSRRKCRLCGTKTTYIDYKNISLLRDYVTEKGKIIPKRITGNCAKHQRMVKEAIQRARFMALLPYTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F445</accession>
    <name>I2F445_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06698">
        <property type="protein sequence ID" value="AFK06698"/>
        <property type="gene ID" value="Theba_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0992"/>
    <dbReference type="HOGENOM" id="CLU_2451149_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="90" mass="10317" checksum="163A7AA308BFBE52" modified="2012-07-11" version="1">MKSNLEDAYSVVTVRDFGKAWRRRTARIQLKKSVVSEVELQRITRKLWETSGQDVDEMITVFYLPGMDTSSVAYGFGSCMKDGIARVSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F454</accession>
    <name>I2F454_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sucrose synthase</fullName>
            <ecNumber evidence="2">2.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose</text>
            <dbReference type="Rhea" id="RHEA:16241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:76533"/>
            <dbReference type="EC" id="2.4.1.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1002"/>
    <dbReference type="EnsemblBacteria" id="AFK06707">
        <property type="protein sequence ID" value="AFK06707"/>
        <property type="gene ID" value="Theba_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1002"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370368_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016157">
        <property type="term" value="F:sucrose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012820">
        <property type="entry name" value="Sucrose_synthase_pln/cyn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839">
        <property type="entry name" value="PTHR45839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="5">
        <location>
            <begin position="475"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="678" mass="76876" checksum="E29CFB8AC0B3AE96" modified="2012-07-11" version="1">MPSKTPERVRDGVVINDDFSASQHLISQLNEPKKLEKLSLHQSNLVRILSAIRMGEVLSYEALETKLREWENDILLSTSLFRGVQRSGRKLAFRDLLTVIGKSEEIDSLLSRVIRYDSSDLVAAKKHASVLLESAVLDGRDGFDPEALLDLWKENERVRSLLLLLSGEKRPLIREMIGKSLGDDLSLHLGIILKAVRYGINLPDNHPALTAGPCLKKIYSLLIDLRDQIRVNSVLVQFSFYGDPLKTGKGSSGGMGTFLRTLGNELTQNLPGVVTIVPLEMREISRMDRLWRTEREHHFLIYVPFLGYEKMIMNNFLEERTTLISNVTDILSIAGISPEQFHMRFSDFASQAMLDLSKKTGIRSFFTVTPDPQWRFVDQKGSLIKLDAVDAVRETSKVEVSWKMLRDCDGLFGIGSEESRNQLLAYYPPLLDESISKKLTMMPEGISLRNECPIFVNGPLYSMLFEKDKEFYLERSFRNNPLLLTVGRLDPAKGQVKLLTAWGNSGLWNSFNLVIVGGDLDHPNRIEANELEEIRKYVRQNKELHGRFCHLPAMNNDEIRCLENSISRVKATPWPPTYVAPSFKEEFGIAILEAMAAGFVAIAPKRGGVKSYIRDGYNGFLIDTTDEVSIEKELRRLLIDVRPSARRMKMIAENGSKTIYRRYSISVVAKQFSSYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F475</accession>
    <name>I2F475_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730738.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1023"/>
    <dbReference type="EnsemblBacteria" id="AFK06728">
        <property type="protein sequence ID" value="AFK06728"/>
        <property type="gene ID" value="Theba_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1023"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_2_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="251"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="496" mass="55047" checksum="FD83D32C38DFDFD0" modified="2012-07-11" version="1">MQSEALVEMEDVTKVYGMHRALDEVSFDLFPGEVHCLVGENGAGKSTLIKILSGAISPEAGIIKIDGKVVEELNPRQSIEMGIATIYQDAELVDSLTVADNVYLGNEITGRIPFVIDSKSQMKKVNEIIAALKMHLPTGALVEELSASQKQMLQIVKALYRDARVLIMDEPTSSLGMDETKALMNIVRNLRERGIGIIYISHYLEEIFEIGDRVTVLKDGKSMGTSSLESVTVEEIIRKMVGRDASLFYTRRKVDIGEVSLEVKNISRWGIVNDVSFDVRKGEVFGIGGLVGSGRSELVNILFGADKADSGEILLNGKKLRIRSPQDAIRQGIALITEDRKKLAMLGGRDVVENTALVHSENFRGFLLNLKEEEDVTDEIVNKLSVAVQDRSQKIEELSGGNQQKVIIGRWLIDDSDVYIFDEPTKGVDIGAREQIYELIVELAERGKCIIMISSDMPELLSMSDRIGVMKNGRMVEIVKNDNIEEEDMIRRFIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B5</accession>
    <name>I2F4B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492808.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1063"/>
    <dbReference type="EnsemblBacteria" id="AFK06768">
        <property type="protein sequence ID" value="AFK06768"/>
        <property type="gene ID" value="Theba_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1063"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="446" mass="49906" checksum="E6BDA7618D0BAB2E" modified="2012-07-11" version="1" precursor="true">MKRLGVILLVLLMLAVPISALGKTTITWWINPWRIAPPGFPSDKAPTEEDFPKWAAEEFMRLHPDVEVKYVVVGNTEYSQKMAAAIATGTQPDIFKGPVWDTRWVEAGLLEPIDDYLTEEDLADFYELALDAGYVDGKHYIWPWNLGTNGMGTSMLLYTPDFEKAGVDWRKIVEEGWTMEEFVEIAKKLTWDSDGDGKIDHYAISFGAQDTHNLMNFIYAHGAKLINEDESKVIFNSPEAVAGLQFLLDLVEVHGVAPSGVEAMGVYDVIGNFHSHRTSIGFGGPYEIGRITRYVKSGQLAEAFYPVIAPFPHLEGHKGVSYASASGFVVFKQKDEAKKEAVMEFARFLTNKENTALLESLIYLTARKSVNAMLFQNDAYLNEQAQTFARIMDETGMEFFGSQSFPWSEISKFFTSAMQGAFGKTKTAQEALDGFVTEANRALSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C6</accession>
    <name>I2F4C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein, possible Na+ channel or pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730777.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1074"/>
    <dbReference type="EnsemblBacteria" id="AFK06779">
        <property type="protein sequence ID" value="AFK06779"/>
        <property type="gene ID" value="Theba_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1074"/>
    <dbReference type="eggNOG" id="COG1811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091659_0_0_0"/>
    <dbReference type="OrthoDB" id="1815957at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="23630" checksum="702BA542DBDA509B" modified="2012-07-11" version="1">MLNISVIVNTVAVIIGSILGLLGGRLLKDRYRKVFFSVIGILTMGLGIEMFLDTNSVLVVLGSLIIGGALGEALDIEEKIGRLAGNKRDDENFVKGFITASVLFVAGPMTVIGSLKAGLSGENELIFIKSLMDGISSMMLSAALGEGVLLSAAAVYLVQGGLVSLAGVLSFLQDPLYLGDFSGVGGMMLLALGIRLLEIKEIRVGNFLPALILSPVLTWVSLLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C9</accession>
    <name>I2F4C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730780.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1077"/>
    <dbReference type="EnsemblBacteria" id="AFK06782">
        <property type="protein sequence ID" value="AFK06782"/>
        <property type="gene ID" value="Theba_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1077"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128747_3_3_0"/>
    <dbReference type="OrthoDB" id="2047418at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="52" mass="5803" checksum="CF93239009473479" modified="2012-07-11" version="1">MKYRCTICGYIYDPEIGDPDNGVDPGTTFEDVPEDWVCPLCGASKDDFEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F9</accession>
    <name>I2F4F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ornithine/acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730809.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1107"/>
    <dbReference type="EnsemblBacteria" id="AFK06812">
        <property type="protein sequence ID" value="AFK06812"/>
        <property type="gene ID" value="Theba_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1107"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_0"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="368" mass="40498" checksum="EAF0224C29E9C2E0" modified="2012-07-11" version="1">MLSNVYLPFPLKIRSAHGIRIETDSGEYLDTFAGIGVLAFGHTDRKTVEAVTSKVQRFSHTSNYFLDEDAISLSKFILDFSNSEGEVYFANSGTEATEAAIKAVRRLKKGKLISFEGNFHGRTMGALSLTYSERLRKPFEPLLPDVRFIPKSVQDFEKAVLSDEIAAVFVEVIQGNSGVHLYPAELLQAIEKLRKERGFLLVADEIQSGLCRTGEYFGYQNYAIEPDMIILGKAVGGGLPLGATVFRGVSPFYPGDHGSTFAPNPVSLAAGLSVLSRMDSALLESVRICGAHLKENLERLPWAREVRGMGLMIGVSTDNPERIKSLAFERKVLLNVTAGSIRFLPALNITEEEIDEITERLDFGGLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G5</accession>
    <name>I2F4G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730814.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1113"/>
    <dbReference type="EnsemblBacteria" id="AFK06818">
        <property type="protein sequence ID" value="AFK06818"/>
        <property type="gene ID" value="Theba_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1113"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_7_0"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="18210" checksum="D6479A4856D63E80" modified="2012-07-11" version="1" precursor="true">MEESSRIQEMLTLVKRIMSVVKQNFESDFKKMGVTQSQILVMRVLNHYGDMKVSDISKELDLSNSTVSGIIDRLVEKKIVQRKRSEEDRRIVMISLADEYRQPVKKGLNAFAQKMRKALSTMTEEDVESIIRGLEKLEKILEESQEPRERGRSRCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H5</accession>
    <name>I2F4H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730822.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06828">
        <property type="protein sequence ID" value="AFK06828"/>
        <property type="gene ID" value="Theba_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1124"/>
    <dbReference type="eggNOG" id="ENOG5033GJG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2422130_0_0_0"/>
    <dbReference type="OrthoDB" id="2030057at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="87" mass="10450" checksum="2A6B625BDF1CB89C" modified="2012-07-11" version="1">MIIVSKEELLAFKKLDLLYQMNLLQEQSVRLERKYDCSLEEFRSLVTDSDENYEMWDDLIEWEACNSALLEVRSMLERINAEDIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I3</accession>
    <name>I2F4I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730828.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06836">
        <property type="protein sequence ID" value="AFK06836"/>
        <property type="gene ID" value="Theba_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1132"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089333_0_0_0"/>
    <dbReference type="OrthoDB" id="1200118at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="195" mass="23334" checksum="8867A42388134CC0" modified="2012-07-11" version="1">MDSTRHQLPQKKIIRIDELKDMGYSFYRIKKLIEENILKKLTRKSYENLIYEGDESDFYYVNAYVPRGVICLISSAIYWQLTTERSTAIDVAIPRSDRIYTMPEWPQIQLYFYSNMRYKTGIVTIHEDSNQFSIYDPEKTVIDILQYRERLGIEVAKEVLVQYLAKKDRNLNRLYRYAKELGNSKILRTYLEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S6</accession>
    <name>I2F4S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-1-phosphate kinase/fructose-6-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730910.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1241"/>
    <dbReference type="EnsemblBacteria" id="AFK06929">
        <property type="protein sequence ID" value="AFK06929"/>
        <property type="gene ID" value="Theba_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1241"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_0_2_0"/>
    <dbReference type="OrthoDB" id="1323781at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="26"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="35014" checksum="5C6E77CC41D5270C" modified="2012-07-11" version="1">MDVLTVTLNPALDREIIVENFKINEFHRVKNPSYSVMDPGGKGINVSVILSGLGVRNVAMGFLGGYIGKVVEERLRLISDLITTAFVHVEEETRENIAIVDPLGETITEINSSGPLIKSDDLRMFIRRFEVALSRAKHVVVSGSIPRGVDNDICKTLCKKVADSGKISFAEGIGPAFEIAVEAGVITVARPDLRSRKLLFGETMVELEDYVRTAKKIIESGSRLAILSYAIEGDVIATRDGIWLFKTKGHIDRSHLLGTGDAFMAGVVHSMIENENDCFLAAKRGMAAAVAEAEYIGKELISLEDIERHLDSFDIRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W7</accession>
    <name>I2F4W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1282"/>
    <dbReference type="EnsemblBacteria" id="AFK06970">
        <property type="protein sequence ID" value="AFK06970"/>
        <property type="gene ID" value="Theba_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1282"/>
    <dbReference type="HOGENOM" id="CLU_1394911_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="195" mass="20961" checksum="9FCC135D73D4043E" modified="2012-07-11" version="1" precursor="true">MKWMIFSLVIVFLLSGCVPMALMMGPEILPSGTLKQAVGMDLLVGFEESILAPWSFQYLARMGLTEYLEGSLRVAIPSIFISAPAATVEAGAKLGVPGFRNAALLVSGGVFLGKKPSGISRDDYFIPFLRVAPMAGFYIRDWMVGAKLQLFVASEVGIIPGLFLTNGKFYFELDIPFAESTSSPDGGLFGISVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W8</accession>
    <name>I2F4W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730947.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1283"/>
    <dbReference type="EnsemblBacteria" id="AFK06971">
        <property type="protein sequence ID" value="AFK06971"/>
        <property type="gene ID" value="Theba_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1283"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034454_3_0_0"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="47396" checksum="CB8E9E06B6B94027" modified="2012-07-11" version="1" precursor="true">MRSLAVALFILAPLIMLSGSVALVLSGGGAKGGYEIGAWKALIDLGVDLGGVYGTSVGSLNAAAVAQGDFDKALDVWRNISEESVMKPTEAQRKLIEAYGGGSDWSLGELYQGAVDVINEGIDVTPLKELLSSLISEEAVRNSSMDFGLVTFDLTDVRPEMLFIEDIPQGSLVDYLMASANFPGFRTVVIDGKAFVDGGIYSNQPVEMALERGFREIILVDIGRTALRDRIGKFQAYLSGAKLTHIRPRVMYGSTLDFDSQKAILQIEAGYLDTLAAFGLTKGKYTYIFENRDVFKMMFDSLSPEEKNEAMKIVNDSREWEDPESFYSELLSSLERIYESEDPMIDVVDELASMLEVPALELYSVEEILQALRGAYLNKGFLDEEVSPGHLRKMLSFFIFLCEKAEIPEPPAQFQLFKSSFMTLRGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X0</accession>
    <name>I2F4X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730949.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1285"/>
    <dbReference type="EnsemblBacteria" id="AFK06973">
        <property type="protein sequence ID" value="AFK06973"/>
        <property type="gene ID" value="Theba_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1285"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705475_0_0_0"/>
    <dbReference type="OrthoDB" id="703457at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024258">
        <property type="entry name" value="DUF3798"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12683">
        <property type="entry name" value="DUF3798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658644" evidence="1">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="391" mass="42670" checksum="8BD408EC99009129" modified="2012-07-11" version="1" precursor="true">MRKALLVLLVVLVSAAFMFAAEFHIGVVTGTVSQSEDDLRGAEALIKKYGDAASGGMIVHLTYPDNFMSEQETVIAQITGLADDPLMKAIIVNQAIPGTVESFRRIRETRPDILLLAGLPHEDPPMLADAADLSVNADSLARGYLIIYTAKQLGAEKFMHISFPRHMSYELLSKRRDIMRAACEELGLEFIDMGSPDPVSDVGIAGAQQFILEKVPAWLDEYGPKTAFFCTNDAHTEPLLKRVAELGGYFIEADLPSPLMGYPGALGISFTEEETGNWPAILAKVEEAVVAKGAAGRMGTWAYSLGYTTTAALAEHAKNVIEGKCEVDDFDAVMAAFAEYTPGAAWNGSYYVDANGIEQENYLLIYQDTYIFGKGYMGITEVEVPEKYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X3</accession>
    <name>I2F4X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730952.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1288"/>
    <dbReference type="EnsemblBacteria" id="AFK06976">
        <property type="protein sequence ID" value="AFK06976"/>
        <property type="gene ID" value="Theba_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1288"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042763_1_0_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="379" mass="40827" checksum="C74BA749AD8CDE78" modified="2012-07-11" version="1" precursor="true">MKDQSLTRAKNPLVRFVISNAVPILFVILLIFAVPLSGFSTDYLLNEIITRLGRNSFLVISLLIPVMAGMGLNFGIVLGAMAGQIGLIFMLDWGVVGIPGIVLAMLVGTPIAILLGMLAGMILNRAKGREMVTSMILGFFINGIYQLTILYGMGSLIPIASDKLLLPRGYGVRNAIDLISVRKALDNMWSIEISGVSIPLGVFAIIAALCIFVFWFTRTKLGQDMRAVGQDMQVAATAGINVDRTRTLSIIISTVLACYGQIIFLQNIGTINTYNSHDQVGTFAIAALLIGGASVAKATIPNVFIGITLFHLTFIVAPRAGKELLGQAQIGEFFRVFVSYGIIAISLALYAWRRQVEKETERRQAKAAIKAAVEDGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F556</accession>
    <name>I2F556_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydro-lyase family enzyme, Fe-S type, tartrate/fumarate subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731005.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1371"/>
    <dbReference type="EnsemblBacteria" id="AFK07059">
        <property type="protein sequence ID" value="AFK07059"/>
        <property type="gene ID" value="Theba_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1371"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_2_0_0"/>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="164" mass="18201" checksum="0DD84C33237388CF" modified="2012-07-11" version="1">MKIDDLVCCQELYYTGKLLVMRDAAQMRLKELHEQDRPLPVKLEGAVVFYAGPAKPTKESFGAIGPTTSIRMDCFLEMLFQQGVQATIGKGKRSDLSTSLCRRYGRAYLLAPSGAAASLSKRIKSLRVIAYEDLGTEAIYEIEVEDFPLIVATDKNGLDIFSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F575</accession>
    <name>I2F575_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486818.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1390"/>
    <dbReference type="EnsemblBacteria" id="AFK07078">
        <property type="protein sequence ID" value="AFK07078"/>
        <property type="gene ID" value="Theba_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1390"/>
    <dbReference type="HOGENOM" id="CLU_1072854_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="259" mass="30237" checksum="B455FC3AECE37696" modified="2012-07-11" version="1" precursor="true">MRKVFVIALSFFVLLSSLFAVFMEEDLSALQFGFSGKVHTVQIEIAKLGAELLISDPETLTFNEKGFLISRETEEVKIEYFYDDSGRLRRKDFINRDGTVFQRVEVLYEDDHYDAVAFDDSGIELERTRYWINSEERTLIFSVETETGVSTNTLFFDENGRKSERYSLIRENVSELDMEVNIVVESTFTYDSNGHLVGEKTVVRVRREGREQASEFRSRIDILLTDEQGNPVRELRRIEFLDSSSAPEEFIYSRVYTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>I2F579</accession>
    <name>I2F579_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Xylose isomerase</fullName>
            <ecNumber evidence="2 9 10">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xylA</name>
        <name evidence="13" type="ORF">Theba_1394</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the xylose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 9 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731027.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1394"/>
    <dbReference type="EnsemblBacteria" id="AFK07082">
        <property type="protein sequence ID" value="AFK07082"/>
        <property type="gene ID" value="Theba_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1394"/>
    <dbReference type="eggNOG" id="COG2115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037261_1_0_0"/>
    <dbReference type="OrthoDB" id="481478at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="12">
        <location>
            <begin position="122"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="440" mass="49907" checksum="8F3E57A0BC2016B7" modified="2012-07-11" version="1">MSVFDKIEKIQYKGPDNKDPMAFSFYNPEEEFMGKTMKEYLRFAVAFWHTFQGDGLDMFGKPTMRRSWDSIKDPIALAKLKVDAVFELCEKLSIDFFCFHDRDIAPEGETLRETNKNLDEIVRHISDHLRTSNVGILWGTANLFSSPRFMHGAATSCDADVFAYAAAQVKKAIEVTKELGGKNYVFWGGREGYETLLNTDMRLELENLARFFHMAADYAKEIGFSGQFLIEPKPMEPTKHQYDFDVANALAFLRKFGLEENFKFNVEANHATLAGHTFQHELRFARINDLLGSVDANQGDPLLGWDTDQFPTDLYSTTLGMYEIIKNGGLNPGGLNFDAKVRRGSYDERDLFIGHIAGMDTFALGLKAAAKLIDEGTLESLLKDRYSSYQSGVGKEITEGIADFRSLEEYIIDKKNPLPEPSNQEYLERLVNWAIISAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D3</accession>
    <name>I2F5D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731076.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1450"/>
    <dbReference type="EnsemblBacteria" id="AFK07136">
        <property type="protein sequence ID" value="AFK07136"/>
        <property type="gene ID" value="Theba_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1450"/>
    <dbReference type="eggNOG" id="ENOG502ZT0X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1967648_0_0_0"/>
    <dbReference type="OrthoDB" id="2101705at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="131" mass="14837" checksum="E92EEAA7A7FE4C79" modified="2012-07-11" version="1" precursor="true">MKERVITFWLLFGGTLLATLSVNSFFGLLLTKREPFLAMIAGINSAIYFLGLAEKRSDLRKRYSHLLVGSFFSYVLSIYQVLVLFSIWLGGLLTSTCLLAFDEMNLPLIISGFALSFLFDFAKKQFETNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E3</accession>
    <name>I2F5E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486994.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1461"/>
    <dbReference type="EnsemblBacteria" id="AFK07146">
        <property type="protein sequence ID" value="AFK07146"/>
        <property type="gene ID" value="Theba_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1461"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_2_3_0"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="91" mass="10130" checksum="63B70B1A7179F769" modified="2012-07-11" version="1">MQGVDNETRKAVLNRLKRIEGQIRGLQKMVENDRVCGDILTQVSAVNSALSKVSEMIVKGYTRKCVIEASKSGQIEELDTLIENIIKLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T9</accession>
    <name>I2F5T9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731191.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1628"/>
    <dbReference type="EnsemblBacteria" id="AFK07292">
        <property type="protein sequence ID" value="AFK07292"/>
        <property type="gene ID" value="Theba_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1628"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262118_0_0_0"/>
    <dbReference type="OrthoDB" id="856739at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="7">
        <location>
            <begin position="631"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1292" mass="145724" checksum="DD83C11149708624" modified="2012-07-11" version="1">MVNKITYSLQQVFAGLELLIKEDYKLLFEKFSPEFGLIETLEEPSGSALAKFSFEFEEDRYSVGFKVLNPDQDGAFSYLSKRYSTPLILLEKRGRSSDYLDLENFWVVPGYYLRMAFVCLQVLRELQSKNGMERLDTVLETAETLLNRTVVGTEILKQYDTSDIEEEPEMKKPKYLKVPILFELPSSNGLLQISELRKAVIPGDKVKESLRLPHFSHLGKLDLLETPESVRIGMNLFLANGARYNASDLEIESSGEDSEALLSPSTCAVPFMAYSDGVRVTMGGKNLKQAVKVVSSEKPIIRTPIDEEVDLDYGVNALAGYALFNGLNFEDGIVCSEGFSMKMCIVEKKTIEIVDSVPVLLDAKVSVKNRSTIELSSEEGSIRIVYNFRTKGSIVNKGDWLIRRNVFFGGNDNPTKSYSKNIYYDLSYPGEILQNPEERMISFIMRTIPTARKIKKGEKLVDNLNESVVSISVPLTITKPLEIGDKITGRHGNKGTISKIVSEREMPHVEIDGQRRPLDIILSPFGVITRMNLGQLLETHKSLEGEYVDKPFKNLDLASRVAKGRDIPQLKKRLFFADGTSFEAAVGYQYFVRLDHCVRDKLHVVDLAETSKITGQPVKGKRREGGQRIGEMEFWTLFDNNALETVGRFSQTNISDSSDFMKRYFDTFRLLMNYYRDFDVEIEDDPLRIIVKETSNDFLEKVASDETMSEFFKQIKGRAKDRKERRFLLSKSGYLRKYMLGRRIHSSGRTVITPVTDIDIDHVYLPYEFAKLWLPLKEDSKEGIKIANDLAKESNLYVLLNRQPSLHRHSISSARPIFWENKTIGLPIMLCDGFGADFDGDSMAVYLPVDQDEDLKRELKSMLPSNNPFRIGTGELTFSVTQDLVYGLYRKRGLNSKKVKEELTQIIENSNNISKDLLKWQNESLAAAKESGLSLDLRDIALMSEVAKSVKDSGSRGKPEHFVQMAEGIDLDGRRAEAFARGVSREDYLGRTDGLDVNIASRSRTGLIDKKLHVAEAGYFTRKLVEFLYPVSVTEEDCCTDDGIELNQSFVQHLALRKYSLERLILGRYVKRPMDKEWMPVTRSNLNDFRDCDLLLRSPVKCASSGENGICSKCAGLELSSMKKFRVGSFLGVLSGHTIGERGTQLSMKTFQTGSSGFSMQRVSSEFFKAEEEFSSYLKRLADRSIEGIMKGSSKSASGSAEEGSPVLGTIDVASIYLEVLFRHLKDTEIRTEGELKKRLSDPREVGIFSALSFEKSGSSEKIGIGEEIEEKSPKANYALRPGEVAKWVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5U7</accession>
    <name>I2F5U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1637</name>
        <name evidence="5" type="ORF">Theba_1714</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MesG1.Ag.4.2</strain>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731198.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1637"/>
    <dbReference type="EnsemblBacteria" id="AFK07300">
        <property type="protein sequence ID" value="AFK07300"/>
        <property type="gene ID" value="Theba_1637"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07371">
        <property type="protein sequence ID" value="AFK07371"/>
        <property type="gene ID" value="Theba_1714"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1637"/>
    <dbReference type="KEGG" id="mpg:Theba_1714"/>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046648_0_0_0"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="326" mass="37476" checksum="265AC5BFC32ACAFA" modified="2012-07-11" version="1">MSITILGHKLKNLPWEEKPKDCLEPVWRYSKNPLITRETVRGANSIFNSAVVAYKDEFRGVFRIDTKELVMELHSGRSEDGLSWNIDQERIEFNAEDPEIGRFVYGYDPRVVFLEDRYYVTWCNGYHGPTIGVAYTYDFERFYQLENAFLPFNRNGVLFPRKIKGKFAMLSRPSDNGHTPFGDIFYSESPDMIHWGCHRHVMSPTAGWQSTKVGAGPIPIETSEGWLLIYHGVWTSCNGFVYSAGVALLDLERPWKVIKRSKHYILNPRMPYENIGDVPNVTFPCASLQDPETGRIAIYYGAADTVTALAFTTSEILYHFLQEHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5V0</accession>
    <name>I2F5V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of various ABC-type transport systems with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1640</name>
        <name evidence="7" type="ORF">Theba_1717</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MesG1.Ag.4.2</strain>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731200.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1640"/>
    <dbReference type="EnsemblBacteria" id="AFK07303">
        <property type="protein sequence ID" value="AFK07303"/>
        <property type="gene ID" value="Theba_1640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07374">
        <property type="protein sequence ID" value="AFK07374"/>
        <property type="gene ID" value="Theba_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1640"/>
    <dbReference type="KEGG" id="mpg:Theba_1717"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="34273" checksum="C3DB68C047E158FD" modified="2012-07-11" version="1" precursor="true">MLELINLTKVFKTGMFSSGRLKAVNNVSFKIEEGEVTSLIGESGSGKSTIGKMILRLLTITQGEIRLDGRDISGLKGAELRDYYRKVQGVFQDPFSSYNPIFKVDRVFENLRSVFFAKMHYSDWMDKVHTVLKLVGLDPDQILGKYPHQLSGGQLQRILISRALLLDVNLLVADELISMLDASTRIDVLNLLADLKKKGLSILFITHDLSLGYYLSERAVILFKGHVVEMGRTDKVFFNPQHYYTCKLLSSVPRLDKKWEDIESDHKKKIDGRKCFDPIMDAEHEMVEVEEDHYVAVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Z4</accession>
    <name>I2F5Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1687</name>
        <name evidence="4" type="ORF">Theba_1754</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MesG1.Ag.4.2</strain>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731241.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07347">
        <property type="protein sequence ID" value="AFK07347"/>
        <property type="gene ID" value="Theba_1687"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07410">
        <property type="protein sequence ID" value="AFK07410"/>
        <property type="gene ID" value="Theba_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1687"/>
    <dbReference type="KEGG" id="mpg:Theba_1754"/>
    <dbReference type="eggNOG" id="ENOG5033D9Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551737_0_0_0"/>
    <dbReference type="OrthoDB" id="1899752at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027783">
        <property type="entry name" value="Bacterial_PH-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10882">
        <property type="entry name" value="bPH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_5" evidence="2">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="19155" checksum="479F59E3A82259CC" modified="2012-07-11" version="1">METIVFKFSLPTSAIMLNIGIVVFVAVIFVFSLFKTKGWQKTISLIIIGSLFVFFIFLFLIFPFTNAVKFDGENVVLNALPFGRKTIAIDSAEIVGIIDWTEERDFEPTVRTNGASTGLYKVGWFRLRNGSKAFIMTARSKAFVMKSEDIYYLISPDELQEFADVIYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F601</accession>
    <name>I2F601_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1694</name>
        <name evidence="6" type="ORF">Theba_1761</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
            <strain evidence="5">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731248.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1694"/>
    <dbReference type="EnsemblBacteria" id="AFK07354">
        <property type="protein sequence ID" value="AFK07354"/>
        <property type="gene ID" value="Theba_1694"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07417">
        <property type="protein sequence ID" value="AFK07417"/>
        <property type="gene ID" value="Theba_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1694"/>
    <dbReference type="KEGG" id="mpg:Theba_1761"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="321" mass="35717" checksum="8ED366656F14F941" modified="2012-07-11" version="1">MGIIEVSGLSKNYNGFTAVKSIDFSVEKGEVFGFLGPNGAGKTTTINMLTGLARPTSGRIDIAGKDGIREIKKVQRLIGIVPDESNLYDDLSGYENLVFCSALYGVRKSEREEKARSLLKQFGLDDTGKRPFKAFSKGMKRKLTIAAGLIHDPEILFLDEPTTGIDVESARQIRSLVRELNDRGTTIFLTTHYIEEAERLCDRIGFIVGGRIVKIGTVADLMKEAQRENIVEFTLGSDPVDLKKQLIEEFSNVTINLRPGNTLRITSLEPIKLMPFMSFFGSRGIDVYEAKIVRPSLEEVFVKVTGIEVEKMKTEKEGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F649</accession>
    <name>I2F649_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative multitransmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1679</name>
        <name evidence="3" type="ORF">Theba_1746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731234.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1679"/>
    <dbReference type="EnsemblBacteria" id="AFK07339">
        <property type="protein sequence ID" value="AFK07339"/>
        <property type="gene ID" value="Theba_1679"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07402">
        <property type="protein sequence ID" value="AFK07402"/>
        <property type="gene ID" value="Theba_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1679"/>
    <dbReference type="KEGG" id="mpg:Theba_1746"/>
    <dbReference type="eggNOG" id="COG5438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028166_4_0_0"/>
    <dbReference type="OrthoDB" id="1746642at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="404" mass="44066" checksum="7CCD4D74E315CA75" modified="2012-07-11" version="1" precursor="true">MSISGSKKRYELLFVLILVAVNIVLIIMPNRYDKSSNYSYTVGKIVEVDNTELKQYGLIKQGSQYLTVEIKRGELKGQVFETDNNLIGKMELDKVLSEGDTVYVEYSTIGDGSIYVKVVDFYRLGTEMLLFTVFGVMLILFAGFTGLKTLLSFTTTLLVLWKVMIPLYLQGFNPVLIAFAIVSALTLAIIFLVGGFTRKGFVAFLGSISGVLVTLILSLSFSDPFYINGSVMPFAETLLYSGFAHLDLNQLFLASIFIGSSGAVMDIGMDLSASMQEVVFKNPDITTRELMFSGFRVGRAVVGTMTTTLLFAYSGGYLTLLMAFMAQGVNTSAMLNLNYFSSEVLITVIGSFGLVLTAPLTAIIGAFVFTRKGSELLIPANQEAGQSVDKKARELGPAINDSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C1</accession>
    <name>I2F6C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488403.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1823"/>
    <dbReference type="EnsemblBacteria" id="AFK07474">
        <property type="protein sequence ID" value="AFK07474"/>
        <property type="gene ID" value="Theba_1823"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1823"/>
    <dbReference type="HOGENOM" id="CLU_2070315_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025597">
        <property type="entry name" value="DUF4345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14248">
        <property type="entry name" value="DUF4345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="12901" checksum="412C4C49A13F87D1" modified="2012-07-11" version="1" precursor="true">MEIAFTIIRFIVAVLTAVTGVYIVLRPESYAKLAEFSTGNSRGRTEVKTIMGGTFIGLGVAPIILLGSTIAFIFLGIVYLFIAATRILSMFVDKSFTFTNLIILLVEMAFGLIMVIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C3</accession>
    <name>I2F6C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabinoheptulosonate-7-phosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1825"/>
    <dbReference type="EnsemblBacteria" id="AFK07476">
        <property type="protein sequence ID" value="AFK07476"/>
        <property type="gene ID" value="Theba_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1825"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="107"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="39344" checksum="69E50AC6E5704877" modified="2012-07-11" version="1">MKGSPIRRPFSFSTGMRGGEMVVVLKRGTGEEEIKQVESLSESLNLSCHVSRGLERVVIGVIGDDRYMSVERFEALECVEQVVRVLKPFKLVSREFHSEDISVEIGDLSVGEGKFIVMAGPCAIEDRPMMEESAAFLSEMGVRVIRGGAFKPRTSPYSFQGLGEIGLRYLREAADHYGLKTVTEVTGEGTLEAVSEMSDILQIGARNSQNFQLIQKVAEKRKPILLKKGFMNTVEELLLSAEYIASRGNMSIILCERGIRTFETATRNTLDISAVPLIKLQSPLPVIVDPSHASGRRDLIIPLSRAALAVGANGIEVEVHPRPEKALSDSKQSLSFGEFEKLMNSLEQLADATELSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D9</accession>
    <name>I2F6D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731310.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1841"/>
    <dbReference type="EnsemblBacteria" id="AFK07492">
        <property type="protein sequence ID" value="AFK07492"/>
        <property type="gene ID" value="Theba_1841"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1841"/>
    <dbReference type="eggNOG" id="ENOG5030M19">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1990016_0_0_0"/>
    <dbReference type="OrthoDB" id="2175695at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="125" mass="13955" checksum="586181E5CB7D4094" modified="2012-07-11" version="1" precursor="true">MRRILAYLLVLLFVVSSASSLIGSSLDVAKEIAESANERIESLIETAIEKAECFTERFEETGLSLEAYENLIDDLGNDLVNTALRISQSAIEKIEEIGYNAICYYVPVKLGYKIFMVDPILIIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F0</accession>
    <name>I2F6F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731316.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07503">
        <property type="protein sequence ID" value="AFK07503"/>
        <property type="gene ID" value="Theba_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1853"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087533_0_0_0"/>
    <dbReference type="OrthoDB" id="1270792at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027365">
        <property type="entry name" value="GNAT_acetyltra_YdfB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12746">
        <property type="entry name" value="GNAT_acetyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="127"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="259" mass="29408" checksum="307DDCD45697BC33" modified="2012-07-11" version="1">MRKIDGSEWRNLLPFLYKNREFSMFIIGDIENTSPDSDNMEIYLDGDFDSPRGILLRYYKFLILSDGAGMNFREAAGVVRRYEQAMMLSGTISGIDRISPYLQEIREEEETLRFAVLREPNLNAAGFEVRRATTEDAEKLLAFLFLIEEFHATDEESFMATLKDGSTRRYIIEDQGEILATAASTSESSDMAMIIGVATGKDFRGRGLASAVVSKLCEDLLAEGRTPCLLYDNPEAGRIYNRLGFREIGKLKTLRFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F6</accession>
    <name>I2F6F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731321.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1859"/>
    <dbReference type="EnsemblBacteria" id="AFK07509">
        <property type="protein sequence ID" value="AFK07509"/>
        <property type="gene ID" value="Theba_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1859"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_5_3_0"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="68" mass="7509" checksum="1CC9217C485DE87E" modified="2012-07-11" version="1">MRLTIEGMSCNHCKMRVEKSLKALEGVKDVEVDLGTGVATISTSKEIEDRLLKEAVEDAGYLLKGIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F7</accession>
    <name>I2F6F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Copper/silver-translocating P-type ATPase,heavy metal-translocating P-type ATPase, Cd/Co/Hg/Pb/Zn-transporting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_1860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731322.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1860"/>
    <dbReference type="EnsemblBacteria" id="AFK07510">
        <property type="protein sequence ID" value="AFK07510"/>
        <property type="gene ID" value="Theba_1860"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1860"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_0"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="813" mass="87251" checksum="33D8D388E44FE0BE" modified="2012-07-11" version="1">MSFENNHVKEEYIVEGMTCAACVRAVEKAVSKIEGVERPVVNLATERLTFEVSQEVDKGRVFEAVERAGYSLKEIPVFRKAVMEIDGMTCAACSAAVEKAIGRLHGVENVSVNLSSDTVSFKYDPNILKIGEVKKVVEKAGYRPGNLVTEAFEESRLKKEAAIASYKRKFIFSAAFALPLLIIAMGHMMGLSLPAIIDPHLNPLNFAIVQLILTIPIVVAGRDFYSKGIPNLFRGSPNMDTLVGLGTGAAFSYGIFATVQIALGRHSYVGDLYFESAGVIIALISLGKYLENLSRGRTSDAIMKLMNLSPETALVKRQDVFEEVAIEEIEVGDVLLVKPGMRIPVDGEVLNGASSVDQSMITGESIPVDISESSKVIGGTTNINGAFEMRATVVGSDTLLSRIIKLVEDAQSSKAPIARMADVVSGYFVPFVLVIAAVTFLVWMTLGYGLVFSMSMMIAVLVIACPCALGLATPTAIMVGTGRGAEMGILFRNGEALETTHKIGAVVFDKTGTITEGRPRLVDVHTFGKHERERVMQISASIASKSSHPLDVAISGAYSGPLLEVSSFEAYSGKGILARVSGQEVKMGNHRFTSLTPEEMKFVDELSSEGKTPVVVSIEGRAAAVLRIADVVREDSLDAIKSLKKMGIDTYMMTGDNSRTAMAIANQVGIENVISEVMPEDKAKKVSDLKREGKTVMMVGDGINDSPALAEAHIGIAVGSGTDIAIETADVVLMSDNLSNIFKAIKLSKETIKNIKQNLFWAFFYNVIGIPLAAGLFYGVAGIRLNPMVAGAAMAFSSVSVVTNALRLKKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S5</accession>
    <name>I2F6S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ORF">Theba_1985</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731420.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1985"/>
    <dbReference type="EnsemblBacteria" id="AFK07628">
        <property type="protein sequence ID" value="AFK07628"/>
        <property type="gene ID" value="Theba_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1985"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_0"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="39"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="219"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="408"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="643"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="571"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK07628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="791" mass="90171" checksum="579B2B987384631F" modified="2012-07-11" version="1">MYDFRAIEKKWQEYYAKEKPFNIDLEKAERPFYNLMMFPYPSAAGLHIGNMFSFIGSDVYGRFMKLKGYDVFEPIGFDAFGIHSENYALKVGKHPAELTPKSIEYFREEQLKKIGNIFDWNSEAITSSPEYYKWTQWIFIQLFKNGLAEKRSSNVNWCPSCKTVLADEQVIDGRCERCNSEVEKREMSQWFFKITEYAEKLLSNLEKLDWTDTTKNLQRAWIGKSSGATISFEVSGMNEKIDVFTTRPDTIFGVTYIVVAPEYGLVSKLITPSTLQAFENFKEEVKNMDLATRTSISRPKNGIFTGSYAVHPLTGEELPIWIGDYVLAEYGTGAVMAVPAHDERDYVFAKKYGLEIKQVIECDPSQLPYTEKGKMINSGKYSDMLSADFIERIDEVSESIKGSVNYHLHDWCISRQRYWGPPIPIVYCDKCGTIPVPEDQLPVTLPNTDDYIPDGSGKSPLAKNEEFVNTICPVCGGPARRETDVSDNFLDSAWYYLRYLSPNDNSAPFDDGLVEKWCPVDMYIGGNEHATLHLMYSRFLSMALHDMGFLPFEEPFTSFRGHGLIIKDGEKMSKSKGNIVNPNEYFESHGVDTLRTYLMFMGTFLEGGDFRDSGMDAMRRFLNRVWDIATMPEGRSSTELKIKMSETVEKVDYSVKNIKPNTAIAAIMEFVNEASKEVSIERQLVIDMAKLLSPFAPFVCEEIYSMKGGKKKTILDDGFPYGYEKYASMAKTELPVQITGKMRGKVVLPQNASQEEAMEAVMADEKLSKMLEGKSIRKIIYVQDKIINIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U8</accession>
    <name>I2F6U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731435.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2008"/>
    <dbReference type="EnsemblBacteria" id="AFK07651">
        <property type="protein sequence ID" value="AFK07651"/>
        <property type="gene ID" value="Theba_2008"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2008"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035600_0_0_0"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="116"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="349" mass="39728" checksum="8AE277CBA7BD8410" modified="2012-07-11" version="1" precursor="true">MKKYMLLLFLLIIGQVFSVYLNDISRDGVTVSWFTEEPSTSYLIVYDGSNESIHSDEEVTLHRFRVSGLLPGMSYAYTVKSEKDGEVIYKGNGILTTAPNRNTPFSFAAYGDSRNNYVVHSEIVHGIASENVPLVIHTGDIVSTDDAIEEWIDFFEVTEVLSDSVLYSVIGNHESEAINYLKFFAFPGNERYYSLWYGDIFFIFLNTNEAFDKYSQQYVWLLTQLEEAEEEDPAHIVVCLHHPPYSYGSHGDHLYLKEYLVPVFENYNVDLVLSGHDHGYQRIERNGVTYVITAGGGAPLYDITRGESLVASAKAFHYMLFNYTLEGLYGYSKTPEGLILDSFYIPKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W2</accession>
    <name>I2F6W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488012.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2022"/>
    <dbReference type="EnsemblBacteria" id="AFK07665">
        <property type="protein sequence ID" value="AFK07665"/>
        <property type="gene ID" value="Theba_2022"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2022"/>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_0"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="40"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="368" mass="40382" checksum="EA9FAE5CE729AD5B" modified="2012-07-11" version="1">MELERILVVDPIDGEYTADVRISGSKIESIKKTGGDFRSIAMPGFVDTHSHGALGINCMTMNHEGLEKWEEFAQSHGVTYLLPTTVSASEEGMKRVADLVSKYISDRSRTVVHGVHFEGPYINPKKKGAQNPEAIRQPTLSEINSVLSDVVMIITMAPEVGGFLEVLPEIIKREITVSIGHTDATYNQIKAAYKLGARRMTHFPNGMNTLHHREIGCVGAGFLLPLNLEMIVDGVHTTPEFVEMVYKIRGSEAIILVTDSLDATGLDNGIYDLGGLRVEVKDNVATLEDGTLAGSTLTMDKAIRNFKRWTGCNFQELAKVSSYNALKNLGISNRGRFKEGMIADIVLLSKELEVEETILAGKSVFISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W5</accession>
    <name>I2F6W5_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2025"/>
    <dbReference type="EnsemblBacteria" id="AFK07668">
        <property type="protein sequence ID" value="AFK07668"/>
        <property type="gene ID" value="Theba_2025"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2025"/>
    <dbReference type="HOGENOM" id="CLU_3382658_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="33" mass="4116" checksum="FA127F57F3D1F1BF" modified="2012-07-11" version="1">MRFREKKDFKAIDRLIESERETVYSNLLINPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X1</accession>
    <name>I2F6X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2031"/>
    <dbReference type="EnsemblBacteria" id="AFK07674">
        <property type="protein sequence ID" value="AFK07674"/>
        <property type="gene ID" value="Theba_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2031"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_1_0"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="311" mass="34494" checksum="ABE6365AD97DB178" modified="2012-07-11" version="1">MSRIAVVGELLIDLISTNTVKDLGEATSFRRFFAGSPGNLASNLNDLGIESILLSRVGNDPFGRAYLEHLRLKGIDTSFVQQDQEAHTSMVFVSRSQSSPQFSAFRGADCLLEEPYDIDSFMKDIDFIHFTTWPLSCERSREVCCKLVDYALRTGVRITFDPNYRQILWTHNQDGSEFIIGFLENVFLVKPSEDDANEIFGPGEPLDYIRKFHESGAKNVILTLGQKGSMISDGNRVVTLPSCARRVVDTTGAGDAFWSGVLFGLLGGKDIFESAVYGNYCAGFRIEHEGKEVILPSIDALKAIFEAGDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F708</accession>
    <name>I2F708_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2074"/>
    <dbReference type="EnsemblBacteria" id="AFK07711">
        <property type="protein sequence ID" value="AFK07711"/>
        <property type="gene ID" value="Theba_2074"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2074"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_9_0_0"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="181"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="47376" checksum="82021EFAA8C05FE8" modified="2012-07-11" version="1">MNEFADQYREIASTMPSEDERIASYNEFLLDRLENIMPRLLAEEEFDAWMVIGRENNEDPIISTLLPGSFYGASRITAFLFTKNNRFVLSPHGSQMSGYYESAWKVEDGDIFDFIGELLRDLKVKTLGVDYSDNFALADGITVSLFQSLKRKLSDEVTLVSAENIAVNWLQTRSEKEIEVYRNLDRIAHVIIRNAFSRDNITPGVTKTRDVELLLKKLAYDIGLKTWFGPDVDFQRKGVEDTRCTGLIEEGDLLHCDFGFMYNGLATDTQQVFYLKKEGYDDLKLGLGEVIRRTNEVQNILARNFREGITGNELLRVSLEDAKVKGLEAAIYSHPVGYHGHGAGPVIGLWNNQDRISGAGDLKIRNMTCFAMELNCRTRLSLWNGQNVYGFLEETVAFTDNEIDYLDGRQKELFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F723</accession>
    <name>I2F723_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731503.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2092"/>
    <dbReference type="EnsemblBacteria" id="AFK07726">
        <property type="protein sequence ID" value="AFK07726"/>
        <property type="gene ID" value="Theba_2092"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2092"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066869_0_0_0"/>
    <dbReference type="OrthoDB" id="1575926at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="37912" checksum="B7D0C3CE27A449D8" modified="2012-07-11" version="1">MRMKRILSVFRIDTINGVRDKMVIYILVAPIIFSFFFRIIAPDFQSLSLSFVSLKDQKATLEALEKFGSVEPVSSEAEMKERVGRSDDSVAIYKKDESFNLFLQGNESEEIEEIAKIILTGLQSDTTRYIDFKESDQGRFVAPVTVFGFTFVVIISFVLGGMVIGFNIIEEKESGAMRALMVTPIKKSELILGRSILGIIIPLIHSFLAVLILDLPTMDYLKLIIVTISSSIIGIVVGFLIGVISSSQMSGIANMKISGWLLLMPVILGFILPERLHFIFFWSPTYWSFVVLKDIVNRSINWSSFTIQILWICLTTAILFLLMMSRIKKGLQTYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F746</accession>
    <name>I2F746_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731522.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2115"/>
    <dbReference type="EnsemblBacteria" id="AFK07749">
        <property type="protein sequence ID" value="AFK07749"/>
        <property type="gene ID" value="Theba_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2115"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_0"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="38382" checksum="232DE9D8067D5478" modified="2012-07-11" version="1">MYVVRTLIMAGGIGERLWPVSVKKRPKQFHKFGSSKTMIEETIERMEKVTDEIIIITTREQFPLMQYYLPLFPGENVIFEPMRRNTAPAIALGSTRFSPDDIMVVVPADHVIRDEESFLKTLNKAIKYAESNDSLVTIGITPTYPYTGYGYIERGNAVDDNEEVYSVKKFHEKPDYETAQHYVQSGRFLWNSGIFVWKKSVFDLELSKNFPDLFSAISEISKRPEDIEKIYERLPKISIDYGLMERSSKVATVPASFYWNDIGSWDAVYDLLIKDKNGNAVEGEFSLKDVKNCLLINHTQKKLAVSGIEGFILVATSEGTLVCRRGESQDIKEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B5</accession>
    <name>I2F7B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731583.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2185"/>
    <dbReference type="EnsemblBacteria" id="AFK07818">
        <property type="protein sequence ID" value="AFK07818"/>
        <property type="gene ID" value="Theba_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2185"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="326" mass="36190" checksum="6D813E869FF1DE66" modified="2012-07-11" version="1" precursor="true">MNCENEPLLEIKDLKIGFKTPEGLLHAVKGISLEVKKREIVGIVGESGCGKTVTALSIMRLLPDNSFATGSINFSGIDLLSLTEDEARGTRGRDISMIFQDSLSSLNPLMKVGRQIDENLMMHTSLDKAERFSRVLEIMKGIGLPDPERTYGKYPHELSGGMRQRIAIAIAIVCNPDLIIADEPTTALDVTVQAQILELLRKINRESNCSIIFISHNLGVIREICSKVYVMYAGHIVERASTEALFTNPGHPYTLGLIKALPKLESKGKELFDIRGRVPSIADLTQGCPFEPRCDYSFERCRKEFPDLKEIDSDHEVRCFLAGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C4</accession>
    <name>I2F7C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731590.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2194"/>
    <dbReference type="EnsemblBacteria" id="AFK07827">
        <property type="protein sequence ID" value="AFK07827"/>
        <property type="gene ID" value="Theba_2194"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2194"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_1_0"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="35333" checksum="3E4AC79933A1FD77" modified="2012-07-11" version="1" precursor="true">MKRTVLFVLLSTASILGMLWFSSFGTISYSLGEIFEILIGNSSGTASSIYLNLRLPRLLVAFLIGSGLAVGGNGLQLTLKNPLADPYIIGISAGASFGAVLSLFLREVSRLDLNMNTLAFAFALFSSFLTYTISRRGGRIPITTLVLSGVIVSFLFNAAVTFLVVFAWRNVITLHFWSLGSLSGATWNDVFKLTPVIFAQYGIFAVIHRKMVIMAAGEEHAITVGVRPELLKFLVFFTVSIVSAVAVSTAGLIGFVGLVIPHMIRLAFGADSKLNLPATALLGGLFLVICDAFARTLFQPTELPIGAVTALVGAPVFIFLLRSKEVAKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F8</accession>
    <name>I2F7F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731620.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2231"/>
    <dbReference type="EnsemblBacteria" id="AFK07861">
        <property type="protein sequence ID" value="AFK07861"/>
        <property type="gene ID" value="Theba_2231"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2231"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_1_0"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="276"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="494" mass="56516" checksum="ABCE4610BFC0FB5C" modified="2012-07-11" version="1">MQTSVKVWPRKLGKINEMIYGHFTEHLGRCIYDGIYNEKSPKSDSRGFRKDIVEAIKRIKCPILRWPGGNFVSAYHWEDGIGPLEKRPQLPNYIWGGVESNRFGTDEFIQYCREIDTEPYLAVSLGTATLDEAISWLEYCNLDTPTKYSRMRKENGHPEPYGVKYWGIGNEVYGPWQVGHCSAAEYAEKLRQYTQFMKGVDRSIKVIAVGADDPNWDLTVLKHAGHLIDYISIHEYHGSDDYLGTVASVYYCEQRLRLLEALIKHLRLDHVKISFDEWNVWYKISAEKEGMDKGIVLLEEPYALKDGLFAAGIFVVMHRMADTVQMANLAQMVNALGMIKTKGDEMVLTPIYHAFDLFVNHTGRTRLNMAVDCDTYDINTRTFVEGRNSFKLNGVPYVDGSATYDEEKQVLSVALINYYQREEEVRLDLSGIEVKKRAVLNVLTGSAPDEMNDFDNPDRIRVQKKVLDNCSTEMFLKLDPMSANVIEFSLESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I2</accession>
    <name>I2F7I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein PII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2256"/>
    <dbReference type="EnsemblBacteria" id="AFK07885">
        <property type="protein sequence ID" value="AFK07885"/>
        <property type="gene ID" value="Theba_2256"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2256"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102878_1_0_0"/>
    <dbReference type="OrthoDB" id="1699192at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="222" mass="24481" checksum="5E6B03A888305952" modified="2012-07-11" version="1">MASNKNISPYKLIYAVVNFGKGSEVLRIARENGISGGTILLGRGTVRSGLLNFFALYEIRKEIVLIVANNRNAKSLLEALDREMMLDRPDHGIAFTVDIQEVEGSKELGCNSLQEGRGEKEIMYQLITVIVDRGKAEEVIDTATEMGSKGGTVINARGSGVHERSTLFAMEIEPEKEIVMIVSNKELTQTIVNKIREKLRIDEPGKGIIFIQNVGDAYGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I9</accession>
    <name>I2F7I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731651.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2263"/>
    <dbReference type="EnsemblBacteria" id="AFK07892">
        <property type="protein sequence ID" value="AFK07892"/>
        <property type="gene ID" value="Theba_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2263"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658569_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="417" mass="45472" checksum="938A5FB8FE44033E" modified="2012-07-11" version="1" precursor="true">MRKRHIILLIVPLVLLLTGCPLFNKLPVWSTIADLSTNIGDIVNVNLSVYCTDPDGDSLNFRLVNGPGSVVGSLYSWTVTAPSGLKTVEVAASDGKGESKTSFKINVKSPPNVPSNPSPAHNADGQSFKNVTLTWTGGDPDGDPVTYDLYFGTSPNPPINSTNLTNTSLVKVGLASFTNYYWKIVAKEGSRVVEGPVWKFTTEPYGIVDDNFESRPLGVLGPSTLPWANYDSSDLSKGAITLFGFAGSRGLTLSDPTLDGYARVLRTGLSPARRGMISFDFSVAANGNFGVGDRTHWAPYIFCGDYGEGFGLYTFSGDYQMMMLISPNTWYTVLMEFDFNFPYRGFSVHVNGAYKGAETYTVTLDFTQFEFLVFSSRLCDYVDFDNVYIGIYDSGYTTSDVDAMSSDFELSTGLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J3</accession>
    <name>I2F7J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diguanylate cyclase (GGDEF) domain-containing protein,uncharacterized domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731655.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2267"/>
    <dbReference type="EnsemblBacteria" id="AFK07896">
        <property type="protein sequence ID" value="AFK07896"/>
        <property type="gene ID" value="Theba_2267"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2267"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014477_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="593"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="6">
        <location>
            <begin position="714"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="904" mass="101320" checksum="9224DFB2F1AC5BF6" modified="2012-07-11" version="1" precursor="true">MKGSRRVISIKWVITIMFMLAITISVGGIGSMIFARWLSSAERTSESIVETISESVFNHIVDFMHEPTHINEANHSIIENNILDLSNEEIREKYFVGVLSSHEAEIYSFSFGTASGEYYGARRNEDGVIEIMRNDASTGGYSWYYSVNEDLTAGERVVVAGKFDPRTRAWYKTAEAEAGPVFSPIYKHFVMDDLTISAAWPVYDREGNLRGVLGTHMLLSGVGGFLKDIVRGYNGYAIIFERDTGLLIANSMELDNFSILSDGTFKRHEIGEIENSYIKKAYNDYSLTQDPHFTYRGESGKLFVGIREIHMPGVDWILMSAIPEALYMTSVVESIHMTVLLVALALIISVIVFNIAAGKLMKPVDNLLEVSAALSSGDLSKRVDVVRNDEIGTISTGLNKVADKMQFLINNLEDSVRDRTEKLHKTNAELEENKNQLQLLLDSTAEGIYGIDMNGNCTFCNTSAARILGYESIEELLGKNMHLKLHHSRRDGTVFPADDCKILRSIKQGRGFEADDEVFWRSDGTSFDVEYHSYPQIRNGKVVGGVITFMDITERKKREEEIRYLSCHDSLTGLHNRSCFENNRKEIDIPENLPMSVIFADINGLKMTNDVFGHAAGDELLKKSAEVLNQSCRESDVIVRAGGDEFIILLPKTDKEEAEKILSRIKIGFSNTRVAAMKCSVSLGLDTKTSIDQPLEVVMANAENSMYRDKTMNRKSSNREIINSIIDTLHSKHPREKQHSVAVSELCSQIGSALNLSLPEISVLERAGYLHDIGKIVLDESILSKVSSKALTEEEREKVRQHSVVGYRILNLFDDTLDLAEYAYSHHERWDGKGYPRGLAGEQIPLISRIISVAEAYERVLNRGDGSIEERRETAIRAVREGAGKQFDPKIAGLFIEMIEEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M3</accession>
    <name>I2F7M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731681.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2298"/>
    <dbReference type="EnsemblBacteria" id="AFK07926">
        <property type="protein sequence ID" value="AFK07926"/>
        <property type="gene ID" value="Theba_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2298"/>
    <dbReference type="eggNOG" id="ENOG5032QVK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140162_0_0_0"/>
    <dbReference type="OrthoDB" id="1782345at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="132" mass="15046" checksum="8100E88B5730B914" modified="2012-07-11" version="1">MKNLDYFAAKSGQKILAALESMDKKELEKLINDILLVLHGNGVYACILYLYAREKKKTETAEKLAKEMLGSVRESLGIDFEDLNEKMNNPEDVLRVVNEKICNNTGSLFLVKDLWERTLVYARYGAKAKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N0</accession>
    <name>I2F7N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731688.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2306"/>
    <dbReference type="EnsemblBacteria" id="AFK07933">
        <property type="protein sequence ID" value="AFK07933"/>
        <property type="gene ID" value="Theba_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2306"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133784_0_0_0"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="165" mass="19185" checksum="A52824524BA2BB62" modified="2012-07-11" version="1">MIDINGSLVLSYTNCRREAWLMAHRIIPEQDNTSMSLGRLIHEASYENRGEKDVSIDNIKLDMVEEKKGKTIVSEIKKSKYSLEGARDQLLFYLLRLKEMGVQAEGQLLVPKEKKKITITLTEEEEERIKKLCEEIQKLVEGPIPEIERAQNKCKNCAYYTYCWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P2</accession>
    <name>I2F7P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731699.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2318"/>
    <dbReference type="EnsemblBacteria" id="AFK07945">
        <property type="protein sequence ID" value="AFK07945"/>
        <property type="gene ID" value="Theba_2318"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2318"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575943_0_0_0"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="474" mass="53718" checksum="8353383724F5A834" modified="2012-07-11" version="1">MNPAVKNENGSPARDPLSRNKFNTQLNTTTFRREWSKSVYPFCNSDITSSIPAEEVSGIGQNFSCPYISKRSGPEKSENGERLTENRQPFPLSYSRIKSFVECPHRFYLRYFEGLPEAQGEGRKHNGLILRALFNSYLGNSPTPLLFGENLKRDLDQIEYGVQFLKSKDVVAINIPFSLDRFSNPVPFNEPEVVFRGVAQALYEDERKNVPRPSSQSMYSSFEKNCEAEFFVSNPGEEANKSLESAFLGLSEDGGPGTVNPSLVLCHFKAGFGDPDWERLFIYAWALSRQGYEIGRIEWVSLSAGASISKEVTKENLEEAGINLYAWISQILQSDFEPEAGDHCSYCLYHSFCPLMEKLGEDLMITDSDSLKSTLQKTVAFQEGAKKMKKLADEFIDREGIGKVELQGYEYASDEAPTQIRLLDREAALDTIIGLPDPFKFITFRNLSELVDYLPEEAYEKKEKLKPVRRFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P8</accession>
    <name>I2F7P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487493.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2325"/>
    <dbReference type="EnsemblBacteria" id="AFK07951">
        <property type="protein sequence ID" value="AFK07951"/>
        <property type="gene ID" value="Theba_2325"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2325"/>
    <dbReference type="HOGENOM" id="CLU_1967951_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="127" mass="14452" checksum="B092B4CCB96E5DA7" modified="2012-07-11" version="1">MRIIRSESFNSEFLDFLDKHNNRVAPVMDKLGFFEEVLERDGPIGVRKSGLLEKLHGTSINSITLIRKGLNVRCLCFFPSDGIEEVCVLLMVFIEKSSADYDKAVRQAEILADKWLSDNKGFKVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q2</accession>
    <name>I2F7Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731706.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2329"/>
    <dbReference type="EnsemblBacteria" id="AFK07955">
        <property type="protein sequence ID" value="AFK07955"/>
        <property type="gene ID" value="Theba_2329"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2329"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803898_0_0_0"/>
    <dbReference type="OrthoDB" id="1916218at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="143" mass="15937" checksum="9BBC95D50A7ADF52" modified="2012-07-11" version="1">MFSWGVGDGNKRMVTENPEPLFKRDSDLLLESADDDTRFELKLIGVMTDISAALINYRADNSLSQKELAEKLECSQAMVSKIESGDYNFTIRKLFDVVNKLGGRVSLEIDFKDGTSVTNSSEERVSIWECVGNQSIKGMKNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q4</accession>
    <name>I2F7Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07957">
        <property type="protein sequence ID" value="AFK07957"/>
        <property type="gene ID" value="Theba_2331"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2331"/>
    <dbReference type="HOGENOM" id="CLU_1842761_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="139" mass="14659" checksum="8255976C056B0FE4" modified="2012-07-11" version="1" precursor="true">MKKIVLIAIAVLLIGGMTLAVGYGSRQIKRAQDVVACETFVDEDGDGINDNCPVDGEKVYMNRKGQAGNEAATRAMQRVQDPTTCENFVDADGDGINDNCPNDGVRELKNAQDGTGYRHGASGEKGPGLGRGFGKAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U4</accession>
    <name>I2F7U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731743.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2377"/>
    <dbReference type="EnsemblBacteria" id="AFK07997">
        <property type="protein sequence ID" value="AFK07997"/>
        <property type="gene ID" value="Theba_2377"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2377"/>
    <dbReference type="HOGENOM" id="CLU_2001180_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="124" mass="13764" checksum="18DE4A2A1317B61B" modified="2012-07-11" version="1" precursor="true">MKKSFLTALSILAIIFLASGCLFFGLPNLNGSWDVVMTYSGGASKTATFHIEQHIIYNYRGKFCLDSTCKELFGMISNDHKVNINTWTSESKIDFAGVAEKGTMSGTFTRFEPSAEGTWEATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W2</accession>
    <name>I2F7W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731757.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2397"/>
    <dbReference type="EnsemblBacteria" id="AFK08015">
        <property type="protein sequence ID" value="AFK08015"/>
        <property type="gene ID" value="Theba_2397"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2397"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_4_0"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="4"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="478" mass="55229" checksum="7EA44C6F6E142542" modified="2012-07-11" version="1" precursor="true">MFYELYLRSFCDGNGDGIGDFIGAERKLDYLANLGIEGIWLLPILHSPSYHGYSVIDFFSVNPIYGTLKDLRNFLASAHKLDLKVILDLPMNHTSPNHEWFLKALNGEKPYRDWYLFLKDEQWLKARRHWDGEQVWTNYSGQWVYTLFGPGSPDLNYESSSLWQQMKEVLTFWLSVGFDGFRFDAAKHIFDFSLEKGICEYQHSRNIAFWKEMTAHCRSISPNSIFVSEVWDDAQIVDLYSAIFGIGFNFPLAEDLKTSVATRDPELLVKSLRTDLNRSFRSKRSYESGVFLTNHDMSRLVSVMDGDEKLSLLAMSVLLSLPGVPFFYYGEELGMEGVYNTYFNEEQLEPFLWFENGYGPGQTEWKALGKNHPHSGRSLEAQKAVDGSYFERFRAILEFRKNNSWLRLATMRGLKRRENLVILRVVGESRSAYIYHNLGKRRVALEDVSNLQIINGSLGRYRGKRYLGGFSSAIEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y8</accession>
    <name>I2F7Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731779.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2426"/>
    <dbReference type="EnsemblBacteria" id="AFK08041">
        <property type="protein sequence ID" value="AFK08041"/>
        <property type="gene ID" value="Theba_2426"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2426"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_1_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="36072" checksum="CB65A6318B9D81DE" modified="2012-07-11" version="1" precursor="true">MRRLTDSNSVLRKLFGKSEFYLLLVIIVVSLFFTILKPSFLTSTNLYGMVESNSFLAIMAAGVLVVLISGGIDISFTAIATVAQYIMATIVINWGGNMFLAFAIGGVVGIALGLVNALLIYFLKTPPIIVTIATMNLFYGLLIFISGGTWIYGFPLWFMERNLVRFGDSPGITIPILVLVLSFILTWLILKYTALGRNIYAVGGNQEAARRVGISVLKTQLFVYCYMGFLAGIASTVQANMMLTVAPNALMGRELEVLAAVVLGGASLAGGTGSILGTVLGFGLIVIVQNGLTLLGISSYWHKVFVGAIIVISVSITAYQRKVRERKGAIINVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F831</accession>
    <name>I2F831_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731816.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2473"/>
    <dbReference type="EnsemblBacteria" id="AFK08084">
        <property type="protein sequence ID" value="AFK08084"/>
        <property type="gene ID" value="Theba_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2473"/>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_0_1_0"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="168"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="399" mass="45899" checksum="923692D0AB60965E" modified="2012-07-11" version="1">MKFEEILDLEERSSFDFFWKESSLSDRGYGLIRDNTKDRNVASIASVGFGLSALPVGVERGWISRKSGEERAVKTLKSFLNNVEQKEGFFVHFIDMIEGRRAYRSEVSVIDTALFLMGGLVAAEYFGGETSELFRTIYGRVNFPWYVNGERNCFYMGYSYERGFWGGWDRYAEQIIMYVLGAASPTCPTDPSLYYSFARDRGTYEELEVIHTYTGSLFTYQFSHAWIDFRKIRDRDGIDWFENSIRASLANWKYCSSEGKNYRTLHERSWGLTACDSPDGYRGDFGAPPSAKSNTAHRIDGTVPPCGALGSIVFVPGIVEETVKHYFENVPELWSEYGFLDAYNLDRNWISDRVIGIDKGITLLMIENYRSGMIWELTMGSEYIKNGLERLGFSRREEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F866</accession>
    <name>I2F866_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731851.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2511"/>
    <dbReference type="EnsemblBacteria" id="AFK08119">
        <property type="protein sequence ID" value="AFK08119"/>
        <property type="gene ID" value="Theba_2511"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2511"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510694_0_0_0"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="538" mass="60799" checksum="E2A0F795D34A5CFC" modified="2012-07-11" version="1">MTEIYDAIIVGGGIAGMTSAAYIAKHGARVLLLEKNEKCGGLINSFWRDGFLFDGGVRALESAGIILPMLRELGIEIERVKSPVSVGIENSVIRVTSKESLKEYSDLLRKMYPGSEDEIERVVSFIKRIMKDMEILYGVDNPLFMDFKNNKSYFVKVYLPWLFKFLFTLRRIGKFRMPVEEFLEKIVQDSSLRDIIDQHFFKNTPTFFAMSYFYLYQDYFYPKGGVGAMAERVKEKIIQFGGEIETGREVTEVHAEKKVIVDSNGRSHKYKKLVWAADLKKLYSIVKTDGLQETATETVNAFRSEISKKHGTDSIFSVFIAVDEPPEKFEAISSGHFFYTPSKKGLGETHRSEMKSILKNWSVNSREEVLSWLDRFCKLSTYEISIPVLKDRDLAPQGKTGLIVSTLFEYDIVKKAYESGWYGELKEELEKRIIEVLSNSIYPILKDRILFSFSSSPLSIESYSGSTEGSIVGWSFEEPIPVVASMMKVNSSVKTKIPDVLQAGQWAYSPAGVPISILTGKLAADSVIKNLNKDRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F867</accession>
    <name>I2F867_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731852.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2512"/>
    <dbReference type="EnsemblBacteria" id="AFK08120">
        <property type="protein sequence ID" value="AFK08120"/>
        <property type="gene ID" value="Theba_2512"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2512"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336056_0_0_0"/>
    <dbReference type="OrthoDB" id="1949554at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="22943" checksum="AF884A17065B315C" modified="2012-07-11" version="1">MNINSLVPDNSEKGTGLIIKHRGLYLFQVSGRKHRTEFGERFFAGIGGHCEEGEGFIQAAKREAVEETGKAVEIIHSARTDIVQPDGSVVDTIELTSPAPRMIYEMLDRRKDLPEKEPYFIACFNAHFADDTPFELDPEEVSALIAIPEELLCESLERKIALEDIISSGGEVVAGSLETGTFLFPLGTAAALAHLLKRAKELSDVDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F892</accession>
    <name>I2F892_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731870.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2544"/>
    <dbReference type="EnsemblBacteria" id="AFK08145">
        <property type="protein sequence ID" value="AFK08145"/>
        <property type="gene ID" value="Theba_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2544"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="259"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="506" mass="55839" checksum="B7C282AEB50597CB" modified="2012-07-11" version="1">MKYIMAHDLGTTGDKATLFSQTGSLVASSFAGYETFYPGPGMVEQDPEAWWTAFCKTTSEIVQMAEIDRKEISALSISGQMMAVVPVDRSGELLRRSIIWADSRSTEQVEELLAKVPASDLYKITGSRLSPTYQGLKIAWLKKYEPDLYERTFKFLQAKDYINLRLTGRFATDFSDAVMTALFDISSLTWSEELISALGIEGSKLPDVYASITDLGEIRKEVATDIGLPNSCRVILGAGDGCSAAVGAGAVEVGDTYLYLGSSAWISTITEEPLLDKEMRVFSGAHAVRGLYFPSGTMQAAGTSYSWIKDTMYCDGSMKESDRDIYSYLDTQLCQSHRHSESILYLPYLLGERSPIWNSNARGTFIGLSASHKKIDIVRAVIEGVSLNLKWILESLEESLPIGKIRVIGGVIKSRIWKRMISTILGKTITIPQNVDEATSIGAAMIAGVGAGLFDFSAVRNFVVDVEEIEPIGEQQEDYLKLYGLFKESYHALEKTFEELNGVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F895</accession>
    <name>I2F895_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731873.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2547"/>
    <dbReference type="EnsemblBacteria" id="AFK08148">
        <property type="protein sequence ID" value="AFK08148"/>
        <property type="gene ID" value="Theba_2547"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2547"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="36904" checksum="8A21C61B02E85676" modified="2012-07-11" version="1">MATTLDDIAKETGLSRATVARAIGKYGYVSKKAREKVIAAAKKLNYKPNYIAKSMATGETKNIGLIVGDIQNPFFSTIARAISDVIVPEGYSLIVTSTDEKVEVEKTSIDRFFQKQVDGLILAPVSRSNSDHLKDLVKSEIPIVLIDRIIEGLDVDMIVSDDLGGGFEAAQYLLELGHRRIGFLSDTLDISTNYDRIAGYREALSKYGIEEKQSWVKLGGFTIEGAYKSGVSLLGQNKDITAVIATNNYMAAGLLLAAKDMGIVVPRDISVISFDDIVWFDLCNPPITSVAQDTREIGSMAAKRILMNIRGQRYEKGLTRLPTRLIIRESCTSPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C4</accession>
    <name>I2F8C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase IS116/IS110/IS902 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK08177">
        <property type="protein sequence ID" value="AFK08177"/>
        <property type="gene ID" value="Theba_2577"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2577"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674068_0_0_0"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transposase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:transposition, DNA-mediated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="3">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="408" mass="46908" checksum="860839D473A35209" modified="2012-07-11" version="1">MEIVGIDWGRKKHYCYLLHQGKKLVLKNKEEDFAKLLKIKEAVYVIEDGNNRIVDYLLRNNRQVYILPSRRSSEARSFFVIEGKSDFIDSKVIAMTYEHNPEWCLQVKREGIAFELDVLVEENAVINVSMMQDIGRLDAYLERYWPEVKEVFSGTSARKLAFISICPTAKDFLSMSDKEILLKLKEMGFLINSNLKSKLKELRKIALERYVPASIRTLIVAFSRYAMEKKVMKEEIGKQMKEIIEKSEFSVLLTLPGVGVIIASQLIVAYLTHKFSSYRDLQRYAGTTPTYYGSGNKNTTKMRSNCNHYLRGTLHIASLAATNSSKWMKRFYDNKKSEGKSSAHALRALANTILKIAFAMLRDLTPYSEEKFLKRNPPSDYTTSKKERKQKPEYSLKVSSVATCRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L3</accession>
    <name>I2F8L3_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2667"/>
    <dbReference type="EnsemblBacteria" id="AFK08266">
        <property type="protein sequence ID" value="AFK08266"/>
        <property type="gene ID" value="Theba_2667"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2020">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_1_3_0"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000002881">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="188" mass="21947" checksum="CBF71AD918E4E308" modified="2012-07-11" version="1" precursor="true">MSGQLLFFIVLFFWVGFDIYLFFLHNRKISERLQEKRSKYIMLAFVLSGMFGAIAVDGRSKEVFLMTFLPHRWIGVGMMIFAVVIRFFVVRQLGPAFAIDVGALPDQKLRTDRFYKVIRHPAYAAEIVGFLGLSLVFNYPLSSILAFVLPTTGILYRISVEERNLKVIFGEEYRDYCKKTWRLIPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M2</accession>
    <name>I2F8M2_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2676"/>
    <dbReference type="EnsemblBacteria" id="AFK08275">
        <property type="protein sequence ID" value="AFK08275"/>
        <property type="gene ID" value="Theba_2676"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2676"/>
    <dbReference type="eggNOG" id="COG5544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2302546_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="100" mass="10987" checksum="C4D149B032803635" modified="2012-07-11" version="1" precursor="true">MVVFVLLFSIVSLAVTGYDKFIHYSVSYSAYGLSSYFLGDIGGFVFSASLGVGKEIWDWFSGKGTAEYGDLIADFAGIISAYSLTKRLPFRPLLVFVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N3</accession>
    <name>I2F8N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731981.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2687"/>
    <dbReference type="EnsemblBacteria" id="AFK08286">
        <property type="protein sequence ID" value="AFK08286"/>
        <property type="gene ID" value="Theba_2687"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2687"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="26097" checksum="97BBDE366121CDBB" modified="2012-07-11" version="1">MTLLETRDLSVSYNEVPALRRVSIKVMKGEVVSVLGPNGAGKTTLLKSISGLVGSEPGSKILLNGEEIQHLAPHKITRLGVIHVPEGRQVFAELSVQENLEVAATRIGLSKARPNIERVYELFSELKSRKNQMAGTLSGGEQQMLAIGRAIVSDPVIMMIDEPSMGLAPVIVKRIFETLKKFVKDTGLTMLIVEQNAKLSLPMSDRVYIVSQGQIKLEGSVDEVKSDERIREMYFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E0I0J7</accession>
    <name>E0I0J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0045</name>
        <name evidence="3" type="ORF">Theba_0117</name>
        <name evidence="4" type="ORF">Theba_1027</name>
        <name evidence="5" type="ORF">Theba_2332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
            <strain evidence="5">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729972.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0045"/>
    <dbReference type="EnsemblBacteria" id="AFK05797">
        <property type="protein sequence ID" value="AFK05797"/>
        <property type="gene ID" value="Theba_0045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05866">
        <property type="protein sequence ID" value="AFK05866"/>
        <property type="gene ID" value="Theba_0117"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06732">
        <property type="protein sequence ID" value="AFK06732"/>
        <property type="gene ID" value="Theba_1027"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07958">
        <property type="protein sequence ID" value="AFK07958"/>
        <property type="gene ID" value="Theba_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0045"/>
    <dbReference type="KEGG" id="mpg:Theba_0117"/>
    <dbReference type="KEGG" id="mpg:Theba_1027"/>
    <dbReference type="KEGG" id="mpg:Theba_2332"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_4_8_0"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="386" mass="44040" checksum="54A49B056B00607A" modified="2010-11-02" version="1">MLYVGVDISSESFDACFYLPEKKKMKSMKYKQDKEGFREFLKKLNTYKDEKQVGMEATGSYHSNLYGFLRSKGIDVQLLDPYTLSKFMKAMSRSKTDKKDAKSIAVAMYRIFDLLSVSQVPEEEMSAFRDLVRVRSTVVANCSDLQRKLKSKLKIHMPELLKTFRSVSSPVLLHLLSVYPSREEILDNEEDAVKLLSSHRNWSEKKAREVIDSLKDSIGKPDTFGTYSTITSTFIAEIKLLKDHVEALNEEIKKFLEKFPDNPLRTIPGIAEVTEAEIVSEVGDIDRFSSGKAFVSYIGLDPVIKQSGNMTRGLSISKKGNKHLRRTFYQLAKSLIKNTEKYRNKYEKMKKRGVKNKVALIATARAAAEMVYQLLKNNVPFDLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I8</accession>
    <name>I2F1I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487474.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0038"/>
    <dbReference type="EnsemblBacteria" id="AFK05791">
        <property type="protein sequence ID" value="AFK05791"/>
        <property type="gene ID" value="Theba_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0038"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098255_0_0_0"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="22193" checksum="6DD79294B1E635C6" modified="2012-07-11" version="1">MICILQNDSDFYKEISPVEKALDNTGYEYSTWRTFLDGFPEDELSCDGLIITGGFSMSNYFEGRALSSGGNFVRSFRGPILGICLGMQILARIGGESLVVSKELGVTKIRLDALHELFSGIESEVSAYQRHNYGLPYVPYGYRQIAWGDETFIQGISSTDGLRFGIQFHPEEIELGSDEQLQRIFANFCRIVSFHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L1</accession>
    <name>I2F1L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729988.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0063"/>
    <dbReference type="EnsemblBacteria" id="AFK05814">
        <property type="protein sequence ID" value="AFK05814"/>
        <property type="gene ID" value="Theba_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0063"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054162_0_0_0"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="152"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="403" mass="46132" checksum="5F58C52367FEF769" modified="2012-07-11" version="1">MTSRERILTALDHNEPDRVPIDLGGMRSTGIHAKAYRRFVDYLGYRDLPVKVFDVHQMLAFVDDEIRREVHSDAIELKRLNGGFETRIDSWNGRNIFDDGSRYLFPDGFDPKVKEDGSLVIERDGVEVAAMPRGGHYFDRSYFPLAHAGRKEEISALVMPRLTGEEIEFLKAQLTGIRESTDCAVIGAFGGNFLEAGHSMFGYQEFMERLITDRPLMEFFLDRLLETYLVDLEKYLSALGDDIDIIQIGDDYGTQENTAISPRIFRSIFKPRLKTLCDFIHRKKPDLFIFLHSCGSVYTFIPDFIEVGVQILNPVQTNAKNMEPERLKNEFGRDIVFWGGGCDTQHVLPFGTLKDLEDDIRRRIDIFSPGGGFVFSPIHNIQAEVPPEKIFRLFECAYEYGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U0</accession>
    <name>I2F1U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with sigma factor-related N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730058.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0151"/>
    <dbReference type="EnsemblBacteria" id="AFK05893">
        <property type="protein sequence ID" value="AFK05893"/>
        <property type="gene ID" value="Theba_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0151"/>
    <dbReference type="eggNOG" id="COG2390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054506_1_1_0"/>
    <dbReference type="OrthoDB" id="1390156at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="64"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="322" mass="37058" checksum="2A93D5B1435B9963" modified="2012-07-11" version="1">MISDELLFEVATDYYVKGMLQKDIANKYGVSRVQISKYLKMAQERGIVHIEVEQPSVKTSIRREYEDFFRERYGLKKMFIARGARNEKTVLKALSREVHKYLRTLPEKPMNIGLGWGNTIFTVAESIERLERPDWQLIPLSGGTARLADKRFNINHIVQNFATRLSGKAVPMYLPFIFENARQLENTKQSLEYMNIQKLWNSLDIIICSVGYSIARSPLFRENLLEVSYADELEKNNVVGDVLTHYFDINGKRFEKSILDKCINLSFEQYMNAGERVIVAAGHHKVDGLVGMLRGGFADVLITDEFTAKFVKEYIVYDEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U7</accession>
    <name>I2F1U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Aspartate kinase</fullName>
            <ecNumber evidence="20">2.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Theba_0159</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="20"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730065.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0159"/>
    <dbReference type="EnsemblBacteria" id="AFK05900">
        <property type="protein sequence ID" value="AFK05900"/>
        <property type="gene ID" value="Theba_0159"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0159"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022318_1_0_0"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="578"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00010046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFK05900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="718" mass="77713" checksum="1D32373C9C594BB0" modified="2012-07-11" version="1" precursor="true">MRIGIAGLGTVGSCVYAILSDKGDEIEKRSGRRCVVSKVITRTHSKYEKLGIPSDLIAEDFEDLIINSDIVVETIGGTEAARKLVKQSLELNRTVVTANKMLISEFGNEFMNSSPIKSLFFEAAVGGGIPIISLLEDYLIFHGIKRIRGILNGTTNFILSEMQKGIDYASALKIAQEKGYAEADPSSDVKGFDAAYKLSVLTGVKTGVFPGISTIETKGIEGIEKSDLERAATAGKKLKLIGTIDFERERASVQPQEVERDDPLWSVDGVENAIEVETDLSGRFLLRGEGAGAQPTATAIISDILRASRYAEKQSNSVVIMKFGGTSVDTPEKIKDVAQRVQRKVLSGVKPVLVVSAMGFETDTLHELAREISDKPNGREMDMLLATGEQKSIALVAMAIQELGMKSISLSGNQARIQTDSNFSNARIVGIDADLINRYLKNGYVPVVAGFQGSTFSGEITTLGRGGSDLTAVVLAKALGSQLCEIYKDVDGVYSADPRIVPNARPIKEISWEEMIELSKQGAQVLQSRASEFVRKYDIKVLVKNAHTNARGTLIWRGSKVEQPIVRAVTSDQDIVKVVLQEVPDRPGIAARVLKTLAEQNVNIDMIIQSMRSGDYNTMAFTIQASDLDKLKQDVLKSRSEAREITVEGAIAKLSIVGVNLTATPAIAATLFETLANEGINIDMISASNSRISVVIDNKKVSLAVNAIHSAFSLEEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y0</accession>
    <name>I2F1Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730097.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0198"/>
    <dbReference type="EnsemblBacteria" id="AFK05933">
        <property type="protein sequence ID" value="AFK05933"/>
        <property type="gene ID" value="Theba_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0198"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_2_0"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="165"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="423" mass="47771" checksum="489931EAE91EF148" modified="2012-07-11" version="1">MNNHYIELPNGAVIIGERKEETRTVSMAFAMKVGSADEEDSISGVSHFIEHALFKGTLRRNAFEIKEPIERIGGSLNAYTGRVSTVYYAKVPDTYASEALEILFDLITSPRFDETSLELERGVIMEEIAAAEDDPYDRIYDMTIEKVWDRDFGRPILGYQDTVGNLKKEKLTNFYDHKYVANNVIFAVSGNYNEDLLKNTEKKLLSMRVNGSKPVAKSPVISKKPLWIVERRKDLQQVHLLLTRDAPGRRNKDDFDAFKIFNTLFGSGMSSILFHNIREQLGMVYNISSEFVSYADSGAFMINATTGPKNLDNLVASLKKEIGNLISRGVTEAQFNYGKERAKGKLLMSTEGTLQTLSRFLDDVVICGKPDSLEDLIARIEALTIDDINDSIKRHIAGPWNVSLLLPEQMQNSTFLKEEHFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z8</accession>
    <name>I2F1Z8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ORF">Theba_0217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730113.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0217"/>
    <dbReference type="EnsemblBacteria" id="AFK05951">
        <property type="protein sequence ID" value="AFK05951"/>
        <property type="gene ID" value="Theba_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0217"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_1_0"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="247"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="452"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK05951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="758" mass="85635" checksum="5348D85076DB03F6" modified="2012-07-11" version="1">MLIQVAISNSPLYDTYTYMTDSPVEPGERVEVNFSGRNTVGYVVSLEGKTGRYRIKSINKRLDGRPFLSSKDLELAEFVMKEYIAPPGKVFDLFFPPGKLLSVDDFVVPLSDELGFSPTKKDKFIKQYGEEKLTELLSLRDVKIMHSFERRTPKKRKIRRISLSLKTDLLKQNLTPLWQTIVDYLLSVESAEVSELEKKLQLKSRSPIETLISKGILTEEETEEDDSHWVIPAVTELNGKQKEVYKSIMESGSKAFLLHGLTGTGKTEVYFKVMEYLLNKGRQVLYLVPEVSLTPQLLARIRGAFPGRDVRQYHSYMAKGLRQQIWLDAVEGNVDILVGTRSSLWVPMKNTGLIVVDEEHDTSFYQQSVPYYDGVEAAMKKAELLNVPIILGSATPRVSHYHLTESGKLILLSLTERPVGSFPIIELIDMKEEKNPIISKRALEEIKKTISAGKQVFVFVHRKGYSNYVVCFTCGNTITCPHCSVSMTYHKADNSLKCHYCGYKEPIPKTCPSCGSMTLSARGFGTERVEHDLQKYFPSAKIMRMDRETIDNPVAYEKALLEISKKESQIIVGTKMITKGLDFPDVEMVLVVDADRLMSFPSYDSPETAFQHISQVSGRSGRAGIGKAFIQSFNPKNRIIKAAFERDYEAFYKDEIALRKELNNPPFAKIAEIICYGDTEDKSGELAERILSEVKAERLDTIEVFGPLTPLLSKLKNSYRMKITIKLPSDSDCGFLEKIQKRHPADVQIIINGIGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F234</accession>
    <name>I2F234_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730147.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05987">
        <property type="protein sequence ID" value="AFK05987"/>
        <property type="gene ID" value="Theba_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0253"/>
    <dbReference type="HOGENOM" id="CLU_1281976_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="215" mass="24116" checksum="EDD1B38597190A76" modified="2012-07-11" version="1" precursor="true">MKRVYIILTVFFLIAFVSFGSMHSSRMMAPGSVRAMAGFKDVGLRIGILSFLEAGWFTDEGPYFTVGYDENFHFASRVSFSSLQEARVIAELGYDFNVVYLEVGGLYEYAAPDASFLGGQLKAEVFFDNDLSIVNATLGRFQKVAGETQKQSYTSVGFSARRRLEIGKQFYFINLESVELVGTLKWEIEDDLSSFSPFPAYSFVGIQFNLGFINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F285</accession>
    <name>I2F285_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730181.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0308"/>
    <dbReference type="EnsemblBacteria" id="AFK06038">
        <property type="protein sequence ID" value="AFK06038"/>
        <property type="gene ID" value="Theba_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0308"/>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_2_1_0"/>
    <dbReference type="OrthoDB" id="1426624at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="269" mass="28784" checksum="683A1DE0DD7DBE7E" modified="2012-07-11" version="1" precursor="true">MLYVVFIGVLMGLANLIPGVSGGTIALLGGLYERFVGSISSVSAFKIRKEDVVFLIEIVAGIVIGILGFSTLIDVSLSRVPSLMYGIFSGLVIGGTPVVFKRIEKFDSSSFSFLVIGGLLVYLVSILASGPGKEAVLNHNTASLLYDVFAGFFGAAAMVLPGLSGAFILLIMGEYTRAIAALRHFDFIIIVFIGVGVILGIVFVSRLMKFLMKRFRSQTFAFLLGLMIGSLPDLFTRPGSNSNVLQIIIGLVSGLAISYLLSMFEKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B8</accession>
    <name>I2F2B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComEC/Rec2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730210.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0342"/>
    <dbReference type="EnsemblBacteria" id="AFK06071">
        <property type="protein sequence ID" value="AFK06071"/>
        <property type="gene ID" value="Theba_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0342"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643837_0_0_0"/>
    <dbReference type="OrthoDB" id="1857516at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="191"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="453" mass="49865" checksum="0042A4B78C9421FE" modified="2012-07-11" version="1">MHDALRRRSTPFPFLFYLLATMLGELIIFSSIWMDSGWLSLALLALSVMLISSKQVSPFAWVLFFVMGCLVQTFTLKMLDPGKVEYVGYVSKGGTGRIEASNGRLLRDGEWIYLPSAVNIDLSDRKAVAFPGQIVWSAGRLKRSDTYPLLTIESEVEGCIDRFEIISLPGKHIAGLLSKYELDNTIAAAVFTGDRKHIEYELRRTISDLGIAHLFAVSGLHVGLMYLLVHSALSFLMVGRNSRIIASISLLFLYTLSTGPAISALRTFLMLLCYSIFRIIDYRQHPLNILGLSGMIIVMVQPSIVASISFQLSFFATAALLIFLPGIEKKSLIYQAFLVGAIAQAAIVPLSLTAFGTLSLVGIPLTILMVPMFVMPSYIGMIAILVSDFLGIEVVSSFISGSLRTMSNIMGKVTASIGEAIPAMRFEAFPAYFISLLVLFLSFIAFWHLGHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C2</accession>
    <name>I2F2C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491922.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0346"/>
    <dbReference type="EnsemblBacteria" id="AFK06075">
        <property type="protein sequence ID" value="AFK06075"/>
        <property type="gene ID" value="Theba_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0346"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731174_0_0_0"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="378" mass="41407" checksum="9A04E2EEA5BA8ECC" modified="2012-07-11" version="1" precursor="true">MRFLRLVKNDLLLIVKSRAFLFVLILLPVILAAISSITSETGGYSDLRIGIINEDKTFIGLFFVQYATSMLKGENILQLSNREEIDSVIDKLDGVFIIPRGFANKLLFQEPSELVFIPNPGSMQTAVAVYQVLSNVLREFKALPVVADPEFMKTVEIDPNYVAPSLTVEGISESKLSFSSLLFPIVLVTTIMFITSIGAATGIYEDRRNGVIDLLRLSDVGSVKYIIAKTVSFLIFSTAQVLIFITAGRLFGLEIASNLILYVVVLEVYILLFTSIGLLIGTILNSSRSAQLTSITLVTAVLILSGILIPHSMFPDWLESFSRSLPTTSLLVVLQGISMLDFTFPMVVLPTAINLLIAIAIIILTGFVASREDISLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E6</accession>
    <name>I2F2E6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730226.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0370"/>
    <dbReference type="EnsemblBacteria" id="AFK06099">
        <property type="protein sequence ID" value="AFK06099"/>
        <property type="gene ID" value="Theba_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0370"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_1_0"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="188" mass="21449" checksum="91015DCA4A82F5B4" modified="2012-07-11" version="1">MRSFIAVDTGERVPAMIDGISEKLRRMGFKASWVPGANAHVTLAFLDNIELEKLALLASMLSRRLRGFPSFTLETGRIGYFKHKDLPKVIWVAIERNQNLVNLQRETRVVLEALSLPVDENFRPHLTVGRMKFSPPMWRKFLSTLENERIIFPVGEVTIFESILSREGATYRKVFTCSFEGGLIEHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F4</accession>
    <name>I2F2F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491968.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0379"/>
    <dbReference type="EnsemblBacteria" id="AFK06107">
        <property type="protein sequence ID" value="AFK06107"/>
        <property type="gene ID" value="Theba_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0379"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="239" mass="27850" checksum="8253E7CBF53F7B0F" modified="2012-07-11" version="1">MAKKSILVVDDEPSIVELLTFNLKKEGYEVLKAYDAEEALKIAEDNETDMFIVDIMLPGMDGFELVRNLRATEKFRQTPVIFLSAKSEEFDKVLGLELGADDYITKPFSVREVLARIRAVFRRIQQSAQAKEERPKKILARDLEIDTEKYEVRVRNRMVNLTPLEFELLRFLAENEGKVFSRDVLLDKLWGYDYYGDTRTVDVHIRRLRTKIEEDASTPKYIITVRGKGYKFRDPGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G1</accession>
    <name>I2F2G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HD superfamily hydrolase of NAD metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491976.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0386"/>
    <dbReference type="EnsemblBacteria" id="AFK06114">
        <property type="protein sequence ID" value="AFK06114"/>
        <property type="gene ID" value="Theba_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0386"/>
    <dbReference type="eggNOG" id="COG1713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089580_1_2_0"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="22136" checksum="86E02AF76F9EBAF2" modified="2012-07-11" version="1" precursor="true">MITEYDTVTREVRAKAKSMCSPERFEHILRVERLAKRLSSIHGIDSSGVGLAAVSHDMFRDQAEDELMRLAISFGIDMTEMERVAPVLLHGKVAALYLKEEYGVDGDVFQAVYWHVSGIPGMSTTGKILMISDIAEEGRDFSEALHIRETAEVDLEKTFVDVIRLKITWAVESDSLLLPETVWTWNELHGGASHVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G5</accession>
    <name>I2F2G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491983.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0390"/>
    <dbReference type="EnsemblBacteria" id="AFK06118">
        <property type="protein sequence ID" value="AFK06118"/>
        <property type="gene ID" value="Theba_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0390"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_1_3_0"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="PTHR11482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="260"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="43429" checksum="DF8B36B532F2B138" modified="2012-07-11" version="1">MHITPEVRKAAREIKTPFLIMDMDYVRNNYFDIVSHVRNVQVFYAVKANSHPRIIETLRDLGSNFDVASRGEIEKLLALGISPERMSFGNTIKKVEDIAYAYSVGIDYYAVDSEMEVEKIAAHAPGSKVYGRIATSGGDCDWPLSRKFGTDVGHVISIMEYADQLGLDAYGVSFHVGSQNYNVNSWDDAIRDASEVFKTLRAKNINLRMLNLGGGMPVKHVREIKSVKSYGDIINRALDKYMSFVPDLELFIEPGRSMVGNSAILVSQVILRSKKGSEDWVYIDAGVFHGLTETIEGFRYEVLTEGKVDDTKISFHLAGPTCDSVDTIYHEIDLPKNIGYGDILYFINAGAYTTEYATNFNGIDAPRVLFVEDFIDAEMPIERDFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K6</accession>
    <name>I2F2K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730274.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06159">
        <property type="protein sequence ID" value="AFK06159"/>
        <property type="gene ID" value="Theba_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0431"/>
    <dbReference type="HOGENOM" id="CLU_1946270_0_0_0"/>
    <dbReference type="OrthoDB" id="2081349at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="129" mass="14784" checksum="77BE93513056FCA0" modified="2012-07-11" version="1">MSEAGHKRSILLYCDRSAFERLLDLFADVSLIDCKGQENEIIGEILENGEGVRKEKTGNGEDGLCYAVFDGFSDESLGNAIDTIRHYTGREWVFATTTESNLSWRMNELLIELTEEHNYFRKARQKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L6</accession>
    <name>I2F2L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730284.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0442"/>
    <dbReference type="EnsemblBacteria" id="AFK06169">
        <property type="protein sequence ID" value="AFK06169"/>
        <property type="gene ID" value="Theba_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0442"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406431_0_0_0"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="676" mass="73224" checksum="C3D80100E615ACD9" modified="2012-07-11" version="1" precursor="true">MRKWFFWALLMVVVVVVFAIRLLPDMLNKPPIISIPDMIIDEGSTLSIDLHDYSSDEKMTSLSYTKISGPGEVKENFYIFSPSFQQSGSHSVTISVVDSKEQMAESSFEIAVREVNRPPELSIPDQVVAEGETISINLDEYANDPDLDALNYSLTEGNGQIIGSNYTYEPDFTSANYERVTISVSDGRGEKAASTFMISNKAFATSSTELTADSTSSVPSETAATSLDSPVTSSETEVADAQNLPPTADVPDQALEQGNTLVLDLRGFVNDPEDEPLSINLKSGPGEVQRTLYSYVSPPGDAGSKTVVLEISDGKNVVEESFQINIESANKAPVASSIPEGVVFQSEQYRLNLENYFTDPDGDSLSFQLLSGPGRIEGSTYIFQSDEPGRYSATIRASDGKGEFIERTANLTVVRTNNPPTISILPRRIAEGDVLTIDLSEYASDPDNDLLSFSLVSGPGTIQGETYTFDADYGTAGTYEAIVSVGDGKGGSARATLRIDVRESNRPPELNIPGFTIAEGSRLVVDLSEYSSDPNNDNLSFEIVQGMGTIEGSRLIIEPGFEDYGFYTIVVSASDGRGGQTSATFDLLITDTNRPPEFNVPDQTTIATRTLRLDLRQFSIDPDGDYLRYELVYGPGVLTGSIYSFIPEELGSNTVMLTANDLKGGEASTTFTITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M6</accession>
    <name>I2F2M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730293.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0452"/>
    <dbReference type="EnsemblBacteria" id="AFK06179">
        <property type="protein sequence ID" value="AFK06179"/>
        <property type="gene ID" value="Theba_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0452"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_0_0_0"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="44442" checksum="F6D3AE1154A7F429" modified="2012-07-11" version="1" precursor="true">MNRLTTDVLIIGGGAAGMSSALSAAKTGADVTLLEREPIAGGVLNQCIHNGFGLQFYHEELTGPEFASRLQREMSEEGVSMIGESYVRHIDVREKKAVVLSPKGAFEISAKALVISSGARERPFGSLLIQGYRPSGILPAGLAQRYVNLENYLPGKRAVVLGSGDIGLIMARRLTLEGVEVVAVIERMPYPGGLTRNIVQCLEDYDIPLLLSTTVTKVFGKGRLEEVEITKVDERFVPIPGTSSRLKVDTLILSAGLLPQVEDFDDDLTIDPINRGFVVSNTGESSVEGVFAAGNNVAVFDLVDYVAAEGWIAGRHAALYALGKNTSGDRVPVVRGDNVGVVVPGIVDMDEHVRLYVRLKNPMDKGTLVLKELGLEKSFSYGVPSEMIQMVIKKEKLMPLIDAKRLTVEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P2</accession>
    <name>I2F2P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">Theba_0469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730308.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0469"/>
    <dbReference type="EnsemblBacteria" id="AFK06195">
        <property type="protein sequence ID" value="AFK06195"/>
        <property type="gene ID" value="Theba_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0469"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_1_1_0"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="190" mass="21186" checksum="1B9DFD9FB53185C4" modified="2012-07-11" version="1">MIVGLVGKAGSGKSTAAERLAKSKMELISLDKLGHDALREEQESLVNSFGRGILTCGNVDRKKLSRIVFENSDLLTKLNKIVHPVIKRKALEIVGKDFSDHYIFDGALIHEIGLAEYCDKIIWFECPNEIAIERLMKRGMSKSRAESILASQQYLDSIKESVDAVVTTLGSSEETFEKLRSILFEWGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q9</accession>
    <name>I2F2Q9_9BACT</name>
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        <submittedName>
            <fullName evidence="1">3-oxoacid CoA-transferase, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0486"/>
    <dbReference type="EnsemblBacteria" id="AFK06212">
        <property type="protein sequence ID" value="AFK06212"/>
        <property type="gene ID" value="Theba_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0486"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_2_1_0"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
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        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="218" mass="23113" checksum="BF609B0A157FBD46" modified="2012-07-11" version="1">MKVVGMKKIVSLIEKGSSVMIGGFLGCGSPDSIIDEIVKNEISGLTLVANDTAFPETGIGKLIVNKCASKIVVSHIGTNPETQRQMIDGELEVELVPQGTLAERIRAGGVGLGGVLTPTGVGTVVQDGKKVLTVDGRDYLMELPLRADFALVKAKKADYFGNLVFSLTARNFNPLMVLACDTVLVEVEEIVPIGSLSPDEIHIPGVFVHYIVVGGRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U9</accession>
    <name>I2F2U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, contains C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730359.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0529"/>
    <dbReference type="EnsemblBacteria" id="AFK06252">
        <property type="protein sequence ID" value="AFK06252"/>
        <property type="gene ID" value="Theba_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0529"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926298_0_0_0"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="37057" checksum="3C1D982074B3CF26" modified="2012-07-11" version="1">MRKGNTLTERNVDDLLDKLRGLFADITAKDIMIKSVVTLTKDRTMWQAKELMRICKISGIPVTDGNNQLEGIVSIEDIIDALEGNYITDPIEKHMTRNIVTFSPEMKLESVIEMFNRYRYGRFPVVDSDGRLVGIISKKDIISAILDKFRLIYVHDKRRKEVLEQSVDWFDKSLITGDYVEKTSADFVYHIDYTDIDTAGVGSAKLKSFLKTLTDDDRLIRRVSIACYEAEVNVVIHSGSEGYIFAWYDENVTRVRVEDYGRGIENVEQAMKEGFSTASDHVRELGFGAGMGLSNMRRYSDKMVVVSEAGKGVVLEMHFYRNGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W2</accession>
    <name>I2F2W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic protein involved in polysaccharide export</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730368.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0542"/>
    <dbReference type="EnsemblBacteria" id="AFK06265">
        <property type="protein sequence ID" value="AFK06265"/>
        <property type="gene ID" value="Theba_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0542"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245372_0_0_0"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="424"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="580"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="741"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1574" mass="169044" checksum="C035F1F404871EAF" modified="2012-07-11" version="1" precursor="true">MHKKIISLSIVLLITMSLLGYSVRPGDLLSISVYGSSDLSSETLVGPDGTVSVPPLGSIMLLGKTLEEIQSFLSSQFLSKGILTSEPQVTVSVKSFAPFMFYVLGEVNKPGAIEWRDETIGISQLLALAGGLKDGADLSSSFIVDSEGTRNYIDLSSILSGGSALKEKISEGSTLFVPTGPRAWIMTMGEFNSPSLVKYSPGITLTQVIAKSGGLKETADDNEIMILSEAKENSSIVSLNSVLSGIKSDPVLSAGSIVIANDASSKSVKLLGEFGNPSSIPYREKLTLLQAIGEAGGVNQAASDQLYILRKDLDEPESVEISKLLSGQIKDIDLYPGETVFVPRQPERYVYIASASFGGKVEFSIDEEITLINALVKVDLFDPVSQDPLVVVTTSGERREFHQGEDAVLDAGSMIILPSGEKSIFVTGEVKNPGILSFSNLEEITLGKAIAKSGGVTEFAGSVELLENGEAKKFSIEDAVKSTLVLSAQSIVNVAEKEHRFVYVVSSAEGGRIDFEEREPFTLRNLLAKMNLLNFNSKKEISIIDTAGMSKFLSVSTLSKEDYQLETGSIVLIPDISTWIYVFGEVERPGKIKLDEDDLLLTRAISASGGFTQNADISSVQVLSGSEISEIDLDEVLKGISSDREISYDDLIYVPRIDSRFVYVVSEENGGRVDFSSGENITLRNALAKLNLVEIASQKEISVISPSGKEIRVSISSLERSDLELESGSVIFYPQADNVANVIGQVRNSGTVNLKPGIPFNLSTVIAAAGGITDLGDEFNITVIDSKSASTAVYSLEDLTRDPIPVIPDGATVFIPELEARFVYVLGGVREPGIKEIGKEEPNPTLTKLIAISGGLSDPLSKEVEIIEDNQRRKLDLQSVMMGRIQDPQVSNHSIIYISETPDRFVYVISKEKGGRVDFGSNEEITLRTALAKQNQLDFDSDGRVTIILPDGTKRERQISDLGESDMNLSPGSIVIYPDVLRQVFVVGAVNKPGLVEFEPGEKVSLTTVLARAGGMTPLALSSKIQITDPFGRTSTVSVDSILLGKALDMNLEDGSFVYVPIYEPVRVNVIGEVKYPGTIEFSKTELPSLLLAISRAGGLTEKAAQNVKITGEEKGVLWLDLVDGKDVMLVSGQTVYVPGDDRYIYVGGEVNSPGKFEFAAQEEITVLRALARAGGEKATASDLVKVLLPSGEILPVSLSNIRNEGKDAVIEPGSTLIVPKQVLRITVLGAVKNPGLFTFNPDEDHSLSDVIARAGGLIDESLVDAIIVHDDKRYNEYTPEVLQKRGNQLSDNTYIYVSSRSPVSVTVLGDVARPGEYEISVRNPSIATAIAVAGGVEKAVTTLSLIGIDGRVQLFDALRTEELARSYLEDGDTIVALRNYDSFVAVVGDVESPGVFPVSDYGELTLAELISLAGGITNFESGGRVFISSGGKTEEIIISPDDFIALTRKVVPAGSTVYVPYTEPARVYVFGEVQKPGIVRYYDGMTAIEALVEAGGPTSYAVLGNALLFQDLEEEPMVIDLDQQKGKPAKGNIPLIPGNIIFVPQSPIVNIKDIMSIVASSLSIVNSAVGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F324</accession>
    <name>I2F324_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730405.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0608"/>
    <dbReference type="EnsemblBacteria" id="AFK06327">
        <property type="protein sequence ID" value="AFK06327"/>
        <property type="gene ID" value="Theba_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0608"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_0"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="3"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="8">
        <location>
            <begin position="335"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="453" mass="49213" checksum="509ED92CE785F755" modified="2012-07-11" version="1">MVDAVVIGGGPGGYVCAIRIAQLGKSVALVEKENLGGTCTNWGCIPTKAMLTSAHLYTEIDEKSKRLGIDTSGLGYDLKRIMSHMNRTITMSRKGIEHLLKKNGVDFYNDVAEIKDAGHVLLKNHGKTLETRNIVIAAGSEPSIFKPFSEIEGIWTSNDVFQMEEMPESLVIVGGGVIGVEFATFFSSFGVKTTIIELADHILPYEDRDVADDIRKSLTRQGVEIIERTKVTEVEKDECIFVLNAEGEQELSVQAEKVLVAVGRRPYITEDVRKLGLEIERGVVTNSRMQTNIKGIYAIGDIRAGMMLAHVASYEGIVAAHNIAGEVMEMDYSAVPSIIFSNPEVGSTGIKEDDVEDMERVIIAKFPLSANGRARTVLENTGFVKVIADKENGKVLGMSIVSPSATELIMEGVIAVRNGLTVEELENSIHPHPTLSETVLGALEGVNGMSIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F329</accession>
    <name>I2F329_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730410.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0613"/>
    <dbReference type="EnsemblBacteria" id="AFK06332">
        <property type="protein sequence ID" value="AFK06332"/>
        <property type="gene ID" value="Theba_0613"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0613"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_3_0"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="431" mass="46881" checksum="09DC11E7897BBAFE" modified="2012-07-11" version="1" precursor="true">MKGLGRNFWLFTLGRLVSLIGSGVQALAIPLYILDLTGSGVMMGTFSVVTMLPRILFGPIAGVLGDRFNRKYIMIYMDFARGAAIILMAYLSDVGVLNLALLFVFQLVISTFDISFDPATSAMLPDIIEEHKLLKANSILGAVNSVSYIVGPALGGVLYGLFGIEIVFIINGTSFILSAISEIFIVYQQTTKKTRVSVKSVFVDIVEGIGYLKKIDGLMMVLMFAMVSNFLSTPIFTVVFPFFARTLVGFSSEQYGFLQSGWVLGVLFGNILIGTILVNKKQGKLFAEGLVTETVLNFLLAALFFPYFTSLFGGPSWLFFAALGIPIVVMGVFNAFVNTPLQTLFHRVLPTSHRSRVFSVISILAQIATPLGSAVFGFAVDRLPVHYLVLISCIANAILTIVFLAKGMSRLFEVRPGKHGGDSYGNAEEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F351</accession>
    <name>I2F351_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NusB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730431.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0636"/>
    <dbReference type="EnsemblBacteria" id="AFK06354">
        <property type="protein sequence ID" value="AFK06354"/>
        <property type="gene ID" value="Theba_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0636"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825803_0_0_0"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NusB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="334" mass="38267" checksum="BABB04F189B5EB8E" modified="2012-07-11" version="1">MQGARSIALQTLSFFDANGYISFRKLDIALSTLSSQDRSFCMNIIYGCLRKRVSIDFELSRFLTKPSKLPHAVLNALRIGAFQILYMKSIPEYAALKSSVDMIGVKEFKGLVNAVLRKLINEGPAERKPLNILYSHPEWLVNYWREFAWIDDFEELLEYNQTPPVQTVISFGRENELIKNGFLFDKSEYSDLSCVFQKGSSIENLQIIDEIEYLLSKTAIPVLTHKGSLTGKINSIPWLLHTLTPEKIDGYSKVAVELLGNFSREHNEFIYYSQAFTVEENKHALDVLEGFEPVMMEDFFAEHKISARFDGKGYWLQPWKAPATCYLARVRSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F397</accession>
    <name>I2F397_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">Theba_0683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730466.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0683"/>
    <dbReference type="EnsemblBacteria" id="AFK06400">
        <property type="protein sequence ID" value="AFK06400"/>
        <property type="gene ID" value="Theba_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0683"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_0"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="24017" checksum="5DA93984FD9E162F" modified="2012-07-11" version="1">MGQKVHPYGFRLGVSKDWKARWINEKNYKEYLLEDLKIRDFLKKNYMAAGVSDIYIERPEPGKVVITVKCARPGVMIGKKGSEVKLLRQRLEKLITRQFQLNIEEVKTPETDAILVAEDIASRIEKRASYKRAMKRAIFTAMRKGARGIKIMVSGRLNGADIARTEWYLEGRLPLQTLRADLDYGYTTAFTKMGIIGVKVWIYKGDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E8</accession>
    <name>I2F3E8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="11" type="ORF">Theba_0736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730507.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0736"/>
    <dbReference type="EnsemblBacteria" id="AFK06451">
        <property type="protein sequence ID" value="AFK06451"/>
        <property type="gene ID" value="Theba_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0736"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_0"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="141" mass="14865" checksum="CAB57D1536B798AB" modified="2012-07-11" version="1">MAKKVIAQIKLQLEAGKATPAPPVGPALGQHGVNIMGFCKQFNAETSDKAGMVLPVIISVYADRSFSFILKTPPASFLLLRAAGIQKGSGVPNRDKVGKITRAQLEEIAKIKMPDLNARTVDAAAKIIAGTARNMGIEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K3</accession>
    <name>I2F3K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730559.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0792"/>
    <dbReference type="EnsemblBacteria" id="AFK06506">
        <property type="protein sequence ID" value="AFK06506"/>
        <property type="gene ID" value="Theba_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0792"/>
    <dbReference type="eggNOG" id="COG1031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533842_0_0_0"/>
    <dbReference type="OrthoDB" id="376425at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="167"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="546" mass="61167" checksum="27A1C1E2FC1799A6" modified="2012-07-11" version="1" precursor="true">MNALIIDGYTDEPAAFGVPPYISPRIRAIAGAFLLKGIETDYLTIDSVRQEGLWEKGNDYNFLIVFGGVTTSGRYIGGTPISSSEISLLLKSNSDPTKIVSGPVVSVGYTLRGGTTAFTPDFGEADYLLRDEFEIADFLDLDSGGSRYSLLNRLYPAGADVIRLHPCFPDLMVEIDISSGCERLDGYCSFCTESILYGPYEWRSIKGIVAEFEKLKQVGVKAIRFGRSANVIAYGYDRRRNTLDPSLSEELFKSARSIIQPEVFHIDNGNPIFIAHHPSESRSVIESVVRYNTVGDTISFGVESFDDEVRSLNNLGGSVQDIMFSIELMNEIGKERVEGVPKLLPGINLLYGLPGQSRNSFDIDYDELVRIQERGLLLRRINIRQTMIFPGARIFNMTRPRIDHRLFEKHKHRIRREIDAEMLKKTFPLGAIIRGVIPEFSEGMIYFGRPLGTYPILVGSPVRFEDRTDFVVIGHGMRSVTGLPVGTELNNLGEREMRFIPGIGRDRAKSLVIKRPRTREELIKIVGPETHKTLSLIKTKLGGKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L7</accession>
    <name>I2F3L7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730572.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0806"/>
    <dbReference type="MEROPS" id="I87.001"/>
    <dbReference type="EnsemblBacteria" id="AFK06520">
        <property type="protein sequence ID" value="AFK06520"/>
        <property type="gene ID" value="Theba_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0806"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059167_1_0_0"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="32657" checksum="B83865053C89C236" modified="2012-07-11" version="1" precursor="true">MKYKVIISVAIIVVIAIILLPSFFFIIDETEQAVVLRFGEIQKSITEAGLYTKTPFIDNVRKFDKRIQIYDVDAERIYSKDKKTILADTFALWRIVDPRKFIETMKSELTALTRIDDVVYSHVRNTFGKLDYDEIISGKRTDVLDEITALAANDMKDFGIQIISVRVKRADLPDENRNAVFERMKSERIQEASLIRAEGNREAQKLRAEADKEAQITIAKAQKEADIIIGTGDARALSIYAEAFNRDPDFYEFMKRLEVYESTLEDANYILGPAMDFIDKLSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P2</accession>
    <name>I2F3P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492535.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0831"/>
    <dbReference type="EnsemblBacteria" id="AFK06545">
        <property type="protein sequence ID" value="AFK06545"/>
        <property type="gene ID" value="Theba_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0831"/>
    <dbReference type="eggNOG" id="COG1347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046659_1_1_0"/>
    <dbReference type="OrthoDB" id="1782047at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
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    </dbReference>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="199" mass="21581" checksum="1D02BFEAC2AA3D8F" modified="2012-07-11" version="1" precursor="true">MADSKKTVFLANIWKNNPVIVQILGICSALAVTNNLTNTLIMGVGLIFVTAFSSLTISALRKLIPRNVRMMIQVLIIATYVIILDIVLKAYLPSISKALGPYVGLIITNCIIMGRAEAFAQSHGPILSFLDGVSAGIGYSLILLAVAFIRELLGFGTIFGVRVMPESFTPWVIMIMAPSAFFILGAIIWIARTPIVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P3</accession>
    <name>I2F3P3_9BACT</name>
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        <submittedName>
            <fullName evidence="8">Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="8 9">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0832"/>
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        <property type="gene ID" value="Theba_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0832"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095255_0_0_0"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NqrDE/RnfAE"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
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        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="21732" checksum="2DB7C27DB32CA09B" modified="2012-07-11" version="1" precursor="true">MGVPLNPFVIMIAAALTSNMVLSNFLGMCSFISVSKDIKTANGLGMAVTFVLTLTSVLNYIVYYYILVPLNLDYLRYIVFIVVIAAFVQFLEMIIERFSPTLYINLGIFLPLITVNCAILGGVLFMIIREYSLIQSLFFGFGSGAGWWLAIVALSAMRMRMRENDLPPQLVGPGITMIIIGIMALAFMGFSGMLPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P7</accession>
    <name>I2F3P7_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0836</name>
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    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    <dbReference type="EnsemblBacteria" id="AFK06550">
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        <property type="gene ID" value="Theba_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0836"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1757306at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="16364" checksum="A9AA465E7F29F804" modified="2012-07-11" version="1" precursor="true">MTKILVSACLIGVNCTYRGDNNLSLKLLELVDRFVFLPVCPEQLGGLPTPRPRAEVTTSADWRAAKLVLDQFGNDVTQNYLRGAEEVLKIAKLSGVNIAILKSRSPSCGCRGIYDGTFSGVMVDGMGITAELLLKNGIEVYSEDETNFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P9</accession>
    <name>I2F3P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730593.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0838"/>
    <dbReference type="EnsemblBacteria" id="AFK06552">
        <property type="protein sequence ID" value="AFK06552"/>
        <property type="gene ID" value="Theba_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0838"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112343_2_1_0"/>
    <dbReference type="OrthoDB" id="2028997at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14265">
        <property type="entry name" value="UDPK_IM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033717">
        <property type="entry name" value="UDPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="143" mass="15885" checksum="BE35E9873B373018" modified="2012-07-11" version="1" precursor="true">MRKFVRSLGNATNGIKHLLRERNFRIQLVIGAVILSLGALIQVDKNDYYWLLFCTFMVLLLEGINTLIEKLADILRPYYDERVRVLKDTAASVVLLGSAVSVLIGLSIILQTIFGSHFAVGLLFGIIILVVFFSLGLFGGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q8</accession>
    <name>I2F3Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0848"/>
    <dbReference type="EnsemblBacteria" id="AFK06561">
        <property type="protein sequence ID" value="AFK06561"/>
        <property type="gene ID" value="Theba_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0848"/>
    <dbReference type="HOGENOM" id="CLU_3404328_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="30" mass="3586" checksum="8B5EF92B10DACA85" modified="2012-07-11" version="1">MRKVIDPASVERAVRKFKEKLARESFPHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R0</accession>
    <name>I2F3R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0850"/>
    <dbReference type="EnsemblBacteria" id="AFK06563">
        <property type="protein sequence ID" value="AFK06563"/>
        <property type="gene ID" value="Theba_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0850"/>
    <dbReference type="HOGENOM" id="CLU_3404329_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="30" mass="3634" checksum="7121E91AD9F86052" modified="2012-07-11" version="1">MKKRNMKEVDRMVSQVRESAFSSLMMNPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R3</accession>
    <name>I2F3R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730605.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0855"/>
    <dbReference type="EnsemblBacteria" id="AFK06566">
        <property type="protein sequence ID" value="AFK06566"/>
        <property type="gene ID" value="Theba_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0855"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="477"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="691" mass="77627" checksum="45B9181A4F5C30EB" modified="2012-07-11" version="1" precursor="true">MGKEALLALVNNAALLITFVVLYTVFYVKSTTSRQIPRQIISGFLLGMVTVGVMLNSWQLSPGVVFDTRSVALGLIGLFFGFIPSMISASMAVGLRILMGGEGTIPGISTILSSVSVGLIWQHHKRRDSCDRSLLELYLFGIVVHVFMLLCMLLLPSQSRETFFEIAALPVMIVYPAATMIVGWAMTGQIARKRGEAAESELASTSERLAVIVKNSPVAIISLDLDYKVTSWNEAAEEIFGWKCSEVLGKPLPYILETQKEDYERMNVETLKGLPVRGERFAQRTKDGREIIIKVYNAPIRDENGNLEGIFGILEDVTEQHKAELALKESELRFRKLYMNMNIGVAIYRVINEGDDVVFLDMNPSGCRITGVNREEILGRSVKAIFPSVVELGLYQRLIEVWKTSRPMHHPVRRYKDERIDFWADNYIYPDRSHEVVAIFEDVTQRELMLEELERRVKNRTEELEAANKELESFAYSVSHDLRAPLRAINGFSKIISDRYMSSLPEEGQRYLGFISKAGGDMSDLIDGLLEYSRIGRSSIHLNELPLKSIVDDCIATLNRRIEEEGAEVSIITDLPTVYANQSLLKRAVTNLLQNALTYHNVGSRPIVKISSKHHKGWVFLTIEDNGIGIEDRYHERIFNVFQRLHTDEEFPGTGIGLSIVKKSVLLMGGDVSLESIPGKGSKFTLKIKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T1</accession>
    <name>I2F3T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0874"/>
    <dbReference type="EnsemblBacteria" id="AFK06584">
        <property type="protein sequence ID" value="AFK06584"/>
        <property type="gene ID" value="Theba_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0874"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="85"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="577" mass="65874" checksum="860C123CC091F1B1" modified="2012-07-11" version="1" precursor="true">MKGDAKVKRISTAFIVVLSFCCVFSRAQDYYVAEVSGKPGGTLSVDGMDPRSLNPAFGNDGASLNILKFIVESLLDENEFGFPEHPALCKDWWISEDGCTLSFVIREGLQWSDGQPFTIEDVRWTFEEIYLVAEMTLFGNSTFMSSAGDLPLVEVEGNTISFTWSEPNALAPRTIGLTPILPKHSLEEYVANGTFPSAWNIGETEKVVVMGPFVIEQFHLGDTIVLEKNPYYWRFDSSGFRLPYIDKIFVKVSTSMEQALLRFEAGELDVYNPSAEQFPRVLSMAEEKGWSVLAGQPRPLTEFLMFNFNAPDPVKREWFRNEHFRKAIAYLMDRESILNTIFSGLGASIHGPLSSSSIYYDPKVEEFNYDFSPTRARLELKRGGFDWRSDGTCIDEFGNPVSFQILTCSWNSQWVGIVTVLSDQLSNIGINATTAFMDWDTYVTKAHSGTFDSMTLAEGGAEPGLLTMVYHSRGVRHYWNYHPDYNLSDHITEETYFYPDWQKRIDEILEAQKSVIELEERCQLFSEFQLVMAQHLPIVFTATQLLLYAYDNSIHHGPWKYGSMFELPWRPWDVWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V7</accession>
    <name>I2F3V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type branched-chain amino acid transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492606.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0900"/>
    <dbReference type="EnsemblBacteria" id="AFK06610">
        <property type="protein sequence ID" value="AFK06610"/>
        <property type="gene ID" value="Theba_0900"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0900"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="39652" checksum="B855FD04160E7864" modified="2012-07-11" version="1" precursor="true">MKRILVLASVLLMGFILFAVEPIVIGVFEPMTGPYAAGGQLTMEGINLAAEQVTEVLGRPIELVLVDNKSEKVEASNAVSRLIQFNKASVIIGSYGSAVAIPGSEVANAAGVPMIGCSPTNPLVTLGKPYAFRVCFIDPFQGSVMAKFAVNELGAKTAVIIQDIASDYSVGLSHYFQNSFKALTGDNKSISGVISYQTGDQDFTAQLAYAQGKNPDVIFIPAASYGEAALIIKQARELGIESQFLGGDTWEVPEFLQVGGAAVEGSYFSTHFDVSVAPTPKAAEFIEAFKAKYGVEPSAFSALGYDAFMLAVDAIKRAGSAVPEDIKNALSETVAFEGVTGYITIDENGDAIKDAIVRKVENGVFKFVSVVKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W5</accession>
    <name>I2F3W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type polar amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492615.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0909"/>
    <dbReference type="EnsemblBacteria" id="AFK06618">
        <property type="protein sequence ID" value="AFK06618"/>
        <property type="gene ID" value="Theba_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0909"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="251" mass="28043" checksum="0419839C55102F4E" modified="2012-07-11" version="1">MSKERVVLRVENLKKAFGDKEVLKGVSFDMKEGETKVIIGPSGTGKSTLLSCINMLVTPDSGQIWLEEEEVTSAKNINKIRQEIGFVFQDFGLFNHLTALKNVMVGLTKVKKIEKDFAKEIAMKELTRVGLEREANMYPAQLSGGQKQRVGIARALAMSPKIILFDEPTSALDPELIGEVLSVMKNLAESGMTMLVVTHEMGFARTVSDEIIFMEHGHIVEQSSPEEMFKNPKNPRTKEFLFKLSELYGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y9</accession>
    <name>I2F3Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730664.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0936"/>
    <dbReference type="EnsemblBacteria" id="AFK06642">
        <property type="protein sequence ID" value="AFK06642"/>
        <property type="gene ID" value="Theba_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0936"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_0"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="78"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="418" mass="46086" checksum="9D2C50865BDE0D0A" modified="2012-07-11" version="1">MSKFLLKCITCGKEFSEEEEEYYCPVCGERRGTLEVVYDFDQVREKYESSSVDLNNRGIWAFDFLLPFENCTDTPRLFVGNTPLYRNHFLEEKYKVSELLLKDDGRNPTASFKDRASGVAVLKAKEKSFDTVFCASTGNAASSLSGFAAVSGLKSVIFVPATAPAAKITQLQVYGSKILAINASYDRVFDLSMEIGMSKGWYCRNSAINPYLLEGKKTCAMEIAFKTKDRLPDFVFVSAGDGTVLSSFYKGFEDLMKLGVISKIPTIVGVQAEGSNAIMRAYERGYPFEPVDIEARTVADSISVGKPRDVFKACRYTQKHNGLFLSVSDGEILGSIIELARETGVFAEPAGATAFAGFKKARRLSIVNERNSVVIVVTGNGLKDLKSVSYVLPKVETLSPVKDAIEEALNEDQLHTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z1</accession>
    <name>I2F3Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730666.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0938"/>
    <dbReference type="EnsemblBacteria" id="AFK06644">
        <property type="protein sequence ID" value="AFK06644"/>
        <property type="gene ID" value="Theba_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0938"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_6_0"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="432" mass="48229" checksum="0489F8F962D3967F" modified="2012-07-11" version="1">MQINNVSIYTNDGDYIPKGFVRVENGKIVKVAAGESAYDGENFYFEGKLLMPSLVNAHTHIYSTFARGLKVAPFNPSSFTKLLEQLWWRLDRAMTVEDLKISAYVAATESLKSGVTSLFDHNSSPNAIEGSLRGIASSVNSVGLRYCGAYEVSDRDGTERRDKGIRENLDFSSESSAYRKGIFGLHASFTLSNETLSLASREIAGKIPIHVHVAEGPEDQEYTVSVHDSRVLERFRRAGLMTENSIYAHCIHTTPSERTLVKDSRGYIVVNCQSNVNNGVGFPEWRNFANEGIRILLGNDGYGFNLCHDVRFLILCPHYIYRDPKVSSSGDIGRSLFGSNYDLATRTFGVNLGTIREGSSADFILLDYKSPTEITAENFVDHFFFGICENIAVSDAFVGGERVLAEGRPTRVNEDDIYKEARKLYKAFEKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F414</accession>
    <name>I2F414_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type polar amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730688.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0961"/>
    <dbReference type="EnsemblBacteria" id="AFK06667">
        <property type="protein sequence ID" value="AFK06667"/>
        <property type="gene ID" value="Theba_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0961"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="248" mass="27390" checksum="50BCBBAC0A544335" modified="2012-07-11" version="1">MKDEKVILKLSNLTKSFDGQVVLKDVSFEVKEGDVIAVLGASGAGKTTLLRCINNLITPDRGEVFFKGSQVQRTKHSIRAFRSRVGFVFQRFNLISHLKIIDNVALPLVKVKNMTWADARKAAEVQLSQVGLADKLNNHPSQLSGGQQQRVGIARALVMNPDIVLLDEPTSALDPSLVGEVMRVIRRLSSEGRTMIIVTHEVEFAKHIANRVIFFKNGEISADCSPAQFFDSMSEEIAEFLTDLSAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F439</accession>
    <name>I2F439_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methylated DNA-protein cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730707.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0986"/>
    <dbReference type="EnsemblBacteria" id="AFK06692">
        <property type="protein sequence ID" value="AFK06692"/>
        <property type="gene ID" value="Theba_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0986"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_0"/>
    <dbReference type="OrthoDB" id="1928537at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="112" mass="12588" checksum="AA1E20CFE59DACAF" modified="2012-07-11" version="1">MVEEDLSTYKKIYKMVRMIPVGRVATYGQIASLVGKCSARMVGYAMAGISDETIPWQRVINSRGRISIRDPNGYTLQKAILEREGVHFDESDTIDLSVFGWEGPEAESAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F442</accession>
    <name>I2F442_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein, HI0933 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730710.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0989"/>
    <dbReference type="EnsemblBacteria" id="AFK06695">
        <property type="protein sequence ID" value="AFK06695"/>
        <property type="gene ID" value="Theba_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0989"/>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="44857" checksum="BBE46070955C75A4" modified="2012-07-11" version="1" precursor="true">MREVVILGAGPAGIFAAINCTTAGRNVTIIEKTSSAGKKLLISGGGQCNLTNAESPSLMLKRYFGAGRFLKPSLMAFDSQKLMDFFERRGLRLHTREDGKVFPVTYSAGDVLEVLLKECDRQGIKIVYNCRAKDVIQFPSGGFLVKTESDSINADYLLIATGGKSYPETGSTGDGFALAKKLGHSLSEQRPALTSVTIRNFGFGDLSGISLRNVEVSLWRNLKKVTTRVEDLLFTHDGFSGPVILHLSREASPGDIIRLNLSGQLREKLEANLISLLSKEGKKLVKNVLDEYGLPERLLSKIIDLAGVGERICSEVRKDERKALVTGLCELDFEIERVGDFTNAMVTRGGVSLSEVNPKTMESRIVNNLFFAGEVLDFDGETGGYNLQAAFSTGYVAGRTINARTSRVENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B9</accession>
    <name>I2F4B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730770.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1067"/>
    <dbReference type="EnsemblBacteria" id="AFK06772">
        <property type="protein sequence ID" value="AFK06772"/>
        <property type="gene ID" value="Theba_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1067"/>
    <dbReference type="eggNOG" id="COG2954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376758_0_0_0"/>
    <dbReference type="OrthoDB" id="1469073at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="23247" checksum="76012896743A0C5D" modified="2012-07-11" version="1">MLEIERKFLFKTKIPEEVIEEATRHLLIVQWYLNPPDRRRIRISVDESDIYVVQTLKSGSGLIREEIEKRVDLSLIIQMRKELRVSRAVMKSRHVYKRNEIEGVVDWYFLPRIGYVLEVETSDPETVLPDPWNYWPLPRDSFEEVTENRSYTARSISVSINSIAGIIPERIESISDHQISEFRRLLQPIYGDSGGIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C7</accession>
    <name>I2F4C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730778.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1075"/>
    <dbReference type="EnsemblBacteria" id="AFK06780">
        <property type="protein sequence ID" value="AFK06780"/>
        <property type="gene ID" value="Theba_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1075"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_0"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="3">
        <location>
            <begin position="195"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="31701" checksum="D61948C0A40238D0" modified="2012-07-11" version="1">MSYLREVEPAWCPGCGNFPLRMNLASTLEEIGVDKSHFIMVTGIGQAAKMPHYLDINFFNGLHGRSLPVAFAIKAVNPELTVIAESGDGDMYGEGGNHFIHGIRRNFDVTVLIHDNQIYGLTKGQGSPTTRKGQKTSSQLQGVINEPLNPLALAITMDAAFVGRTFIGDKDHFRKVVSAAIKHKGFSVVDIMQPCVTFNKVNTFKYYKDRLYDVHEKDASYDPKDKVKAFEKALEWDEKIPMGILYLNEKPTYHELHPVLKKGVILLKERSSIDVSSELEAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D0</accession>
    <name>I2F4D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Desulfoferrodoxin ferrous iron-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730781.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1078"/>
    <dbReference type="EnsemblBacteria" id="AFK06783">
        <property type="protein sequence ID" value="AFK06783"/>
        <property type="gene ID" value="Theba_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1078"/>
    <dbReference type="eggNOG" id="COG2033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118960_2_1_0"/>
    <dbReference type="OrthoDB" id="1496450at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="6">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="117" mass="13311" checksum="879C49642173D56D" modified="2012-07-11" version="1">MAIGEYVKSADWKSEKHVPVIEIPDSVKPGEAFNVQITVGKEISHPNTIEHHIKWFDLYVMYDDGQFLIHLGHIEFTPVNTQPTAVFNVKLEKSGSLIATSYCNIHGLWESSKRVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E2</accession>
    <name>I2F4E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AroM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730793.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1090"/>
    <dbReference type="EnsemblBacteria" id="AFK06795">
        <property type="protein sequence ID" value="AFK06795"/>
        <property type="gene ID" value="Theba_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1090"/>
    <dbReference type="eggNOG" id="COG4126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077346_0_0_0"/>
    <dbReference type="OrthoDB" id="1537462at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010843">
        <property type="entry name" value="Uncharacterised_AroM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07302">
        <property type="entry name" value="AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="200" mass="22731" checksum="1A3C5BAF6DA18504" modified="2012-07-11" version="1">MTFLTIGQSPRDDLVPELIRIIGKPLEVKEVGLLDGMEVKDFVTPFSEKDLLVSRLRDGREVELSEEWVREQLLAFEVKEATVLLCTSEFNIVKYIEPYTVIRSFLRSQGPFESLAVVVPEKKQEPLARRWKGLSTRLEVFSFSPYEGSPSIPSGLTDSKYIYLDCMGYGLDHESRIQEVALGTVISARRIVGEFLRTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E5</accession>
    <name>I2F4E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730796.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1093"/>
    <dbReference type="EnsemblBacteria" id="AFK06798">
        <property type="protein sequence ID" value="AFK06798"/>
        <property type="gene ID" value="Theba_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1093"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_6_0"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="331"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="576" mass="64861" checksum="8EE2E309B18D91A7" modified="2012-07-11" version="1" precursor="true">MIRDFLKHNWPRYLYGSIFLILVDLLMLVTPRVIGMIVDEIRGGAQDLNLVGLLILAVIGVAFGLFITRLLWRIFIMGAARRFEYYTRKTLFEKLLTLSPTFYDKTRVGDLMARFTNDVNAVRMAMGPAIVMIIDAVFLVTVTIIAMGLFTNWSLTWISIAPLPALAVVSTFFGKMIHKRFKLVQASFSDLTDTIEESISGVRLIKSYGIEDLRNETLTEKSNLYVDKNMNLVKVWGMFFPLTQTLSMLGSVLATLFGGRMVILGQITLGEYITFTSYLGMLVWPMTAFGWVINIIQRGRASYRRLMEVLEEENNITTNDPIEVVSFEGHVVMKNLTFTYPTGTRPALENIDFEVKPDSKIAIVGTTGSGKSTMAKLIARLYPVEEGMLFIDGVDINNLRPEAIRDNVAYVPQETFLFSETVGNNIRFGNMEISDEEVERYAKVASIHEDIEGFSKGYKTIVGERGVTLSGGQKQRISIARALIKEAPLVILDDCLSAVDTETEAEILKSLKESEINRSIIVISHRLKAVVDSDEIYVLHDGRIVEKGAHADLVEAGGLYQRMYERQMLEEKLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F4</accession>
    <name>I2F4F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminopimelate epimerase</fullName>
            <ecNumber evidence="4">5.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730804.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1102"/>
    <dbReference type="EnsemblBacteria" id="AFK06807">
        <property type="protein sequence ID" value="AFK06807"/>
        <property type="gene ID" value="Theba_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1102"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_3_0_0"/>
    <dbReference type="OrthoDB" id="1921631at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="26555" checksum="B41D3C732C7DBEF4" modified="2012-07-11" version="1">MMRGAYYTATGNTFLVVDSRERKLSDMEKRLLVLKYVDGRDGAIFVERDFMDYYNCDGNRAAFCGNGARTYVYFIHEKEKRNLVEFSSHAGNVLGKVDDLVSVRMPSPRFLGTFEEEDYSGEIVVVGVPHLVIEGDTDKVDWNALLPLRHLYDANINVFTVKKEGSLRIRTFERGVEGETGACGSGATSVVWLYSRRTGCEKVILQANGGDLTVSFRDGSAYLGGGVEKCSEELELQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H2</accession>
    <name>I2F4H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1120</name>
    </gene>
    <organism evidence="8 9">
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="EnsemblBacteria" id="AFK06825">
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        <property type="gene ID" value="Theba_1120"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <location>
            <begin position="219"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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    <sequence length="696" mass="77114" checksum="C9FE8C5879AEEF29" modified="2012-07-11" version="1" precursor="true">MINRRISIFIIALFAVVTVVMGLFILRVEINVSSEFLLPEKSPSRENMRMMEDLFGREKQIIIVVKTDGLFEEENSLRIYDFLQKLSMIEGVVSYNSYQDAAKVSLIGGTNVEPYFENGVAKENAREILQNPLYLDNLLDENGEVALIPINVTENADVNAILETAGESFEGMEFYASGEPIIDEELYGSILSLLVVYPPILFGLICFIYFLRLGSVRAAIIPSILSIVAAVWTYGFGVMIGLNINILTSTAGLFIIIISSSYGLHFIDRYITNRRFLERSSALKRTVREELIPVFLSALTTAVGFLTFLVSSLEAFRQLGIMVSLGIMVSSVLVLIALPAVLVFVDLPAVKRKLRLRAPTREVAKNIDTVVLVVILVFAVVSPFLISKIDRNFDQYDYFKKSSSIVKSAETIKEEFGWNMPFYVILNKNGLFTGADASVLSKLIVEINELEEVRGVSSIMDVSSAFGIPLPILQIAARNGDLPVEQYMVGNSIRLLVKTPNTDAVNSQRLENELKEILEDYPQYSPYVASPLLIISGVNNEILSSQVTTIIWALVVITLLLIIVFRSFKLALVSVLPIALSVFFNFSYMSILGIKLEISTAIVAGVLLGMTIDYAIHLINRFMDTKDIYRAREEVRPAILSNTIALAAGFASLLFAPLRLFSGLGLLLAIGMLTGAIVTLTIIPKIVSKWKMSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
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                <person name="Bruce D."/>
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                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
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                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK06850.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K4</accession>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Bruce D."/>
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                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
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                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="Theba_1159"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AFK06857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="65" mass="7538" checksum="AA1A4813654423C6" modified="2012-07-11" version="1">MKEPRMIVNEDGKPVSVILSISTYKKILDELEELEEIRAYDKAKKSADEILPFEEALEKSKRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K9</accession>
    <name>I2F4K9_9BACT</name>
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                <person name="Swithers K.S."/>
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                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
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                <person name="Dlutek M."/>
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                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13629" checksum="B990F4F36ECCC87A" modified="2012-07-11" version="1">MEIERLNIWKLGVELAKDVYVLTEKFPKKELYSLTDQIRRAAVSVPSNIAEGKGRSSAKDFINFLSVARGSLYELITQLYIAREIGYLTQEDFSTLQKRIEDLSHKIVAMTKYLRNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V1</accession>
    <name>I2F4V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_1266</name>
    </gene>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730935.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1266"/>
    <dbReference type="EnsemblBacteria" id="AFK06954">
        <property type="protein sequence ID" value="AFK06954"/>
        <property type="gene ID" value="Theba_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1266"/>
    <dbReference type="eggNOG" id="ENOG502ZMWU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1617078_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="164" mass="18588" checksum="C62FD2D350F8470B" modified="2012-07-11" version="1">MDEERFVRILDREIPFDKLRVDERKELKGYVKAIDALKESCCYRPSDELKKRTLSSVRKLKSRPYKILGTVAACLVLGIFSVSFFTGNTILIKKKGELYQLADVLGSSSSLNERLKVNLNAFAQDEAEGNNLVMMEKEMERSLGFLSESAVENDFEISGISTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V2</accession>
    <name>I2F4V2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730936.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1267"/>
    <dbReference type="EnsemblBacteria" id="AFK06955">
        <property type="protein sequence ID" value="AFK06955"/>
        <property type="gene ID" value="Theba_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1267"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="186" mass="21883" checksum="49581676A362A804" modified="2012-07-11" version="1">MDEKKLIDGLKKKKVWAYEVLYDEYAPRLGSVVKSYLGYDDVEDVIQEVFIKVFKNVRKFRGDAKLSTWLYRIAVNVCKDTLVKRKRNNEFLTDFRESEDKATFEPPATTNVFREVMDEISFEELMSVVERLAEDDRLLIKLRDIDDLSYEEIADILDKPVGTVKSRLHYARKRLKELLEEVGYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y7</accession>
    <name>I2F4Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1302"/>
    <dbReference type="EnsemblBacteria" id="AFK06990">
        <property type="protein sequence ID" value="AFK06990"/>
        <property type="gene ID" value="Theba_1302"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1302"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="228" mass="25720" checksum="64C25CE61DBA1881" modified="2012-07-11" version="1">MISGGVVLRILIVEDEETISAFLQKGLREEGFVVDSAKDGNEAIRLSSSNPYDVIILDVLLPIKNGFEVCSELRASGNHTPVLMLTALDSVDERVKGLNTGADDYLVKPFAFKELLARVNALLRRPRESFDRVLRVSDLSIDTVSHTVKRGDKEIELSPKEYRLLEHLARNAHQVLSRTQIAESVWDQDFFSDSNVVDVYIRYLRKKIDDPFPTKLINTVRGFGYKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F501</accession>
    <name>I2F501_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ileS</name>
        <name evidence="11" type="ORF">Theba_1316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730975.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1316"/>
    <dbReference type="EnsemblBacteria" id="AFK07004">
        <property type="protein sequence ID" value="AFK07004"/>
        <property type="gene ID" value="Theba_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1316"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_0"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="688"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="601"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1047" mass="122057" checksum="1263ADF51A9E1AF0" modified="2012-07-11" version="1">MPRFEDVDLKRPAAEREEEILSYWRKDDLATRSVTEREGSPEFVFFEGPPTANGMPGIHHVISRTLKDAVCRFKTMQGYQVKRKAGWDTHGLPVEIEVEKQLGFSSKQEIEDFGIEKFNQKCKESVWKYESQWKKLTERIAYWIDMEHPYITMENDYIESVWWILKQYFDKGYIYEGHKIMPYCPRCGTPLASHEVAQGYKDETIDSIYVKFRLKGKDNEYFIVWTTTPWTLPSNVALAVNPEFNYVKVEVKVDGDEVEYYYLVKERLSALLGEESNYRIVQELKGMDLVNLEYEQLIPFAKVDKKAFYVVYGDFVSLEDGSGIVHMAPAFGEDDNILGRKFGLPLLQLVDKEGKITEEVTPWAGMFVRDADPLITRYLKDRNLLFKKERLTHSYPFCWRCDTPLLYYARKSWYIKTTEYRDKMIEVNNSVNWYPKFVGEGRFGNWLENMVDWALSRDRYWGTPLNVWKCDECGKLTAVGSRKELVERAIEDISEDIELHRPYVDDVHLRCECGGRMTRTPEVIDCWFDSGAMPVAQHHYPFENKDNFMGDLFPADFICEGIDQTRGWFYSLMSISTFLFGQSPYKNVLVNNLVLDKNGQKMSKSKGNTVDPWKIIEKYGADTLRWYLLAVSPPWVPTKFDEEGVKDTFSKFFGTLHSVFSFFTMYANVDNVDPGEFDLPVSEREEVDRWIISRLNTLVREVTDLLNHYDMTKSVRAIQDFVVEEVSNWYVRRTRDRYWTSELDNSKKAAYLTLYEVLLTVAKLMAPIAPFTAEEIFRNLTHKEKESVHLEFYPVADESLIEPDLEKRMAAVMDIVTLGRACRNKVQIKVRQPLPKILVDGRIKKIVESMRELILEEINVKNIEYIEELGDYVNYEVKPNFRVMGPKFGKDLKAIGNALRSMKPADVVARVKHEGKISIEAEGKTFELTEEDLDIRIQELEGFTFEMSNENFVILDTELTPELLQEGLAREMVSKIQTMRKEADFEITDRINVSFSGPREVVDAIDTYREYIKEETLSNAVVFEESLDSGTEWNLNGYDTLIRVQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F503</accession>
    <name>I2F503_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486709.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1318"/>
    <dbReference type="EnsemblBacteria" id="AFK07006">
        <property type="protein sequence ID" value="AFK07006"/>
        <property type="gene ID" value="Theba_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1318"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_0"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="167" mass="17948" checksum="09035900802E19D3" modified="2012-07-11" version="1">MKDKRVTITLNGRKTTLVVEDRTTLLNALREQGVTSLKRGCEEGECGACTLIMNGLPQKSCLILAREAEGADILTVEGLVKKGRLHPIQQAFIDEGAIQCGYCTPGMVMTTYALLKKNPSPSDEEIREALSGNICRCTGYLAIIRAVKKSAAILSGNNGGGGTREDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F513</accession>
    <name>I2F513_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterial nucleoid DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486731.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1328"/>
    <dbReference type="EnsemblBacteria" id="AFK07016">
        <property type="protein sequence ID" value="AFK07016"/>
        <property type="gene ID" value="Theba_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1328"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_2_0"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="90" mass="9892" checksum="FB9205B5B81E0638" modified="2012-07-11" version="1">MNKKELIAVLAEKTGATKKLVGDVIDGFIDVVGEELSKNEEVKLVGFGTFEVTKRKARKGVNPRTKEAIEIPGGKVPKFRPGKELKEKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A4</accession>
    <name>I2F5A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731052.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1421"/>
    <dbReference type="EnsemblBacteria" id="AFK07107">
        <property type="protein sequence ID" value="AFK07107"/>
        <property type="gene ID" value="Theba_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1421"/>
    <dbReference type="eggNOG" id="COG3333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022936_2_0_0"/>
    <dbReference type="OrthoDB" id="735109at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="503" mass="52779" checksum="756A84839EB46962" modified="2012-07-11" version="1" precursor="true">MVEQILAAIDLRFIFLVFVGAFAGLVVGAMPGLSVTMATAILVSVTFTWTVNDAMALMMGVYVVGVFSGAISAILINIPGAPASVATTLDGFPMTMKGQARKALRVATVYSFVGTLFGLIMLALLAKPVTKIALQFSPMDYFLLALFGLTTVGSLTSKNFLKGLISATLGVIISLIGIDPIMGTPRFTFGSMKLQAGISLIAALIGLFGFSEILVQIGQRSLQPIAGKLGKEKVGFRQLMRHIPLSLQSAVIGTFIGALPGTGGPVASLIAYDQAKKTVRKPEVPFGEGAVEGIVASESANNACIGGALIPMLTLAVPGDAVTAVLLSAMYVHGLRPGPLLFTQTPDLFYVILAAGIIGSLSIIALGIGVAPLMARMVLIPKKILLPVVAILCIIGAYAINSSVFDILIMAIFGLIGFVMRRKGYSVAPMVLGIVLGSLMDANFRRAVSLASAGDNLIISMFSRPISIILIVFILISLFSNFKFVKTGVRKLFSGRSDKGKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E2</accession>
    <name>I2F5E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486992.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1460"/>
    <dbReference type="EnsemblBacteria" id="AFK07145">
        <property type="protein sequence ID" value="AFK07145"/>
        <property type="gene ID" value="Theba_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1460"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023775_1_0_0"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="2">
        <location>
            <begin position="291"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="555" mass="63502" checksum="FE2EC3BDA45F1E2A" modified="2012-07-11" version="1">MADHEIFVKELGKKIHVTKETSFFELSKMCGELHKAPIMAAKSGNSLIELCRNVNGESEVEFIDLFSLDGIRIYTRGALFILFIAIRELFGSAQLNVHHSRGTGLVCNIEGIESTPENLLQIEERMRELVKEDIVFEKATLRKFEAIRLFSEDGQRDKALLFKYRKKSTVNIYRCKGFINYFYGYMPYSTGAILNFSLIPYGDYFILNLPDTKQPDRLPKFVDQPKISTIFLEHERWGEILGVKTIGEINEIISKGPREIREIVNITESLHEKKIGAIADQIAKHKEPSLILIAGPSSSGKTTFSKRLMLHLKVLGMNPVQISIDDYFVDREKTPLDENGNYDFESIHALNIDLFNEQISQLLDGKEVLLPKFDFMLGKSGFHDKPIRISEGQPVIIEGIHGLNELLSSSVPRHRKFKIYVSALTQMNLDSLNRIPTTDVRLLRRIVRDNRSRGHSALDTMRMWPSVRRGEDKYIFPFQEEADVMFNSAIVYELAALKGFAEPLLVQIDDSVPEYIEAKRLLRFIDYLLPMMNLEDIPRTSIIKEFIGDSVFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E6</accession>
    <name>I2F5E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731083.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1464"/>
    <dbReference type="EnsemblBacteria" id="AFK07149">
        <property type="protein sequence ID" value="AFK07149"/>
        <property type="gene ID" value="Theba_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1464"/>
    <dbReference type="eggNOG" id="ENOG502ZVTU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233833_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="224" mass="25801" checksum="47BA1F650A267C3C" modified="2012-07-11" version="1" precursor="true">MKIASVSILISLIALICGLLVIVYMNFETIQNVGSRRATPDFFLRNNFIPLLERFKNHLEETKEFSSVLQQLEREGVGPWIMSAEKGIRTFTCPYKEVFSRLQTLFYIETGKNGIREHETVEFFGSTVTRMESIDYGAFRLTYLPGYTLVMESDYNSFLKEGFRFYRVHFMHSISPGSFVSDVFAGSGPVVVLREGGVINQSFIETVERYSIPYLPVRYFLIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G8</accession>
    <name>I2F5G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bacterial cell division membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFK07171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07171">
        <property type="protein sequence ID" value="AFK07171"/>
        <property type="gene ID" value="Theba_1489"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1489"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_029243_1_2_0"/>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
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        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
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        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="40695" checksum="A614ED9CC0A148CA" modified="2012-07-11" version="1" precursor="true">MKRTYLVLALYTSVFVIFGLVFIYSAGISMEARHPDVTASEFLEKQLIAYAIGLAGALIMIYMKGSWHFKNAFTIYYPLTLIMLVAVLFFPDRGGSNRWIDIGSFSLQVSEFAKISLLLVLAKHFGGLKKRNFLTTFLIPLGITAPLAILVFIEPDLSTTGIIVAIAFVMMIIGGIKMRYLSLALIFVVILVLVLYSGGFIEDYQIQRITSFLTSLTGEEHEQVSYSLMAISSGGLTGKGLGMGLVKYYLPVSYSDFIFAVIGEELGLVGLLVLMFAYVGFIRELIVVGLRGSRTLEGKLYIIGFALYIMIQATINIGVNLGLFPPTGVTLPFVSSGGSSIMSLMIGYGLVFSILLESEEEKEKGLQDEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
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    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="152" mass="17939" checksum="1A11D0D35D593EB4" modified="2012-07-11" version="1">MIIREIRDTDAPGLHEVLVDIGWFKMKNVEEEIYLKSVKEMIRWSIERDDHLILISEEGGELTGYTSVHFLPYLFMGKPEGYVGELFVKTVWRGKGFGSELLRRAINEARERGCCRIRLINIRDRESYRRGFYAKQGWQERTDAADFMMKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q4</accession>
    <name>I2F5Q4_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="366" mass="42202" checksum="9AD33A041FE8B4EC" modified="2012-07-11" version="1">MDFSSGTLRNLMTLKNARRGRISSYDESGGNKDWKAIAAGETLVLGEIEGPGVVSHIWMTFRSTEKHFLRKGILRIFWDDESAPSVESPIGDFFGAGHGKTVNFSSLPIQMSPEDGRGFNCFFPMPFRKKARIEIANENSSQDLVAYYYIDYELWPELPENIAYFHAQWRREQGVSRDESNLVKSLAPNNLKDFALEPFVANNIFEFQGQNKTGRDNYVILDAQGKGHYVGCFFYVHNMRETDQWDWYGEGDDMIFIDGDSWPPSLHGTGTEDYFSMAWCPSQSYASEYFGLILPGNNNWKGYMSMYRFHIEDPIYFSKSLKVTIEKGHNNNRFDDYSSVAFWYQAEPHKRFESLLPSEDRLPYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5U3</accession>
    <name>I2F5U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_1633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07296">
        <property type="protein sequence ID" value="AFK07296"/>
        <property type="gene ID" value="Theba_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1633"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1581397at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="49072" checksum="03B89684576152A8" modified="2012-07-11" version="1">MKYYSLIDKVYLEKNLLKAYGRVKSNRGAPGIDGVSVETFGEKLLEEIERLSGEIKRGEYKPMSLRRVEIPKADGKTRQLRIPAVRDRVVQQSLKEVLEPIFEEGFHPSSYGYRKGRNAWQAVEKAKAFASKYGLCNVVELDLSECFDTLDHEKIIDSVAERVSDGKILKLIRAILKSGVMEDGVWKATETGSPQGGVISPLLANIYLNEFDQKMKARGIRIVRYADDILIFSKTQEEAREFLAIAINILEIDMKLKVNRNKTRITTLEDGFHFLGFEIKGERVGIEKSRLKRFKEKVRKLTRRNQSRPVKEIVKQLNPLLRGFASYFRIVDFQSILRGLLSWIRRRLRAIILHQWKTTKKLNRVLRRTGWKEKVNMRMNKWRSSHSKAANYAIPNRFFEEMNLVDMTKYHHPLSKYPILDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X2</accession>
    <name>I2F5X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731220.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07325">
        <property type="protein sequence ID" value="AFK07325"/>
        <property type="gene ID" value="Theba_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1663"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48638" checksum="024094B1B0207604" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDTLEVTRQRCWQYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLKLHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTFRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSQLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F686</accession>
    <name>I2F686_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-fucose isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489189.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1788"/>
    <dbReference type="EnsemblBacteria" id="AFK07439">
        <property type="protein sequence ID" value="AFK07439"/>
        <property type="gene ID" value="Theba_1788"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1788"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039041_0_0_0"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="7">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="8">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="6">
        <location>
            <begin position="333"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="472" mass="53145" checksum="477F9C7AD6ED175F" modified="2012-07-11" version="1">MKKRKVGVITFSDGRDFVHNDLIEMNKGFQDRLVKALEATGEVEVVTASDIVWKPSLAKKAGKELMKAEVEATIFNYAIWCWPHLSVMASLYAPGPFLTYGQINPSYPGMVGQLAAAGALEQVGIMPERVWGNPEDSDVIERVMHFVRAASAAARLKGERYGMFGGRPMGMYTASANGDQWLKEFGVDVEQIDQYELVVRAEKVPKDVTKAAREWLEKLATVKYDGKQLTPEKLEKQIALYEAALSIIKEYELDFVGFKGQPEMTNNYATMDIVEAFLNDPYDWHGSKETIVAATETDMDGALTMEIFKHIAQSPVLFADVRHYFEEEDLLDLCNSGTHATYFAGKSMNPEDNLKHVELYPEDFYFPAGGAAVKHFAAPGRVTLARLARQNGEYIMTIVPGEFVKLSEAEEKKLSEKVQIEWPHAYVKLDTDMDTFLRYYPCNHTHGVYGDFVEELVQFCDIKGIDYQILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D4</accession>
    <name>I2F6D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488376.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1836"/>
    <dbReference type="EnsemblBacteria" id="AFK07487">
        <property type="protein sequence ID" value="AFK07487"/>
        <property type="gene ID" value="Theba_1836"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1836"/>
    <dbReference type="HOGENOM" id="CLU_1052953_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="29848" checksum="61C37425D90B9080" modified="2012-07-11" version="1" precursor="true">MSKGIAWLLVVLISAAAIVNLATTVITSNKLLEEISTVRTDLFTLKSRVASLDTVVTDIRNRIEQSGDFVKSVHFTRSSTTLEKVALKASVTLSEFTEGSQLFLNIIDEDAEVRSYELKSENGVFTAMIELLPDETYHGQVRVIDGNKETLSNEFAIPHDLYNVQRYQLLGHAWLLETDKIHYSFDLYTHYCKDEELRISEAAIKVVEGQDTRETLFLPLGNSQELAKTVYYEADRDASPTFVAEITYGFGESKTEEVKINYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D7</accession>
    <name>I2F6D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_1839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731308.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1839"/>
    <dbReference type="EnsemblBacteria" id="AFK07490">
        <property type="protein sequence ID" value="AFK07490"/>
        <property type="gene ID" value="Theba_1839"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1839"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_1_1_0"/>
    <dbReference type="OrthoDB" id="1507622at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="11"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="35021" checksum="57F14E2E3C980A6F" modified="2012-07-11" version="1">MGEFSIVATINERRLLKSIEMSGASAIRFNSSHVSLEELQKFISYYEDNCALPLYIDLQGAKLRLSRSQPIMEVKAGEQVVLGCRSSQLRSIAVDPRTLSYLSPGMRVSIEDGRIELQVLKLEADFARAMVLRGGVIRPAKGMNISPHPINQIELSSRDSDIVLATRKYGFVRYALSFVSSPSEVIELKELSGREVASKIERELPFSRIEEISASSDEIWFCRGDLGAQLGARGLVDFYAFFSDNLRKLYKPVLMAGEVLEHMVDAPFATRSELCHLKDIQRRGFAGVVLSNETAYGSFPIETIKTVLEVTSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G2</accession>
    <name>I2F6G2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">Theba_1865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488307.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1865"/>
    <dbReference type="EnsemblBacteria" id="AFK07515">
        <property type="protein sequence ID" value="AFK07515"/>
        <property type="gene ID" value="Theba_1865"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1865"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_0"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="148" mass="16310" checksum="1CEB758ECFC53ADE" modified="2012-07-11" version="1">MRAVVQRVSSASVVVDGKVTGKIDKGLLVLVGIGREDDERDVEWLVDKTVNLRIFEDENDKMNLSLIDVSGSLLAISQFTVMGDARKGRRPSFTDAAEPEVARGLFNDFLQMASKTVRVETGIFQAHMDVELVNSGPVTILLDSKRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I8</accession>
    <name>I2F6I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731343.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1893"/>
    <dbReference type="EnsemblBacteria" id="AFK07541">
        <property type="protein sequence ID" value="AFK07541"/>
        <property type="gene ID" value="Theba_1893"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1893"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_0"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="169"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="30007" checksum="66CABD2F0CC584F8" modified="2012-07-11" version="1" precursor="true">MRNEFDGSEWLRLIKTMKILRSPGGCEWDIEQTHQSLKPYLIEEAYEVLDAIDGGDDKELVEELGDVLLQVVFHAQIAMERKAFTITDVLQVLTDKLIRRHPHVFSDSEGYSYRQWEEIKAKEKAKDSGKSSSIGEINKALPALSLARRVQENASVVGFDWGEIEGPREKLNEEIEELDSAIVEKDKKKIEEEIGDVLFTVTNLSRFLDVDPEVALRKSTEKFLNRFHEMESHIEKHGLDINNMTIDELNHLWEIAKEGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R6</accession>
    <name>I2F6R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731411.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1976"/>
    <dbReference type="EnsemblBacteria" id="AFK07619">
        <property type="protein sequence ID" value="AFK07619"/>
        <property type="gene ID" value="Theba_1976"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1976"/>
    <dbReference type="eggNOG" id="ENOG502ZBH5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107131_0_0_0"/>
    <dbReference type="OrthoDB" id="1710953at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046272">
        <property type="entry name" value="DUF6305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19823">
        <property type="entry name" value="DUF6305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657659" description="DUF6305 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6305" evidence="2">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="211" mass="22218" checksum="5D8441DEE31D5282" modified="2012-07-11" version="1" precursor="true">MRRFLLVLIVVSLVSVFAFAEPEVKLGLPVVITSAGQSAEVETVNYVADEVGLKYDYCDVLSKDELAAGVGLGGAKSAIGKHVTTLSPDPEGTKFQSLLLVLGASLKGMGASGLSVDTEVDRLKDLIEYAKANKIKIVAVAIGGEIQRGLPGSPIEVIIDTVVPHADVFIVTKDSNGDGKFTKAAEARNVPIVEIDSAFDLLDTFTQVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U6</accession>
    <name>I2F6U6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_2006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731433.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2006"/>
    <dbReference type="EnsemblBacteria" id="AFK07649">
        <property type="protein sequence ID" value="AFK07649"/>
        <property type="gene ID" value="Theba_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2006"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_0"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="69"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="292" mass="32064" checksum="2E89343E86405C44" modified="2012-07-11" version="1" precursor="true">MRRRRLELSSRVLVTTAALITSAILFGIFFFLISDGVRVFGKISFEEFFFSARWYPTYEDAEYGILALLSGTLAVTGLTLAISIPLGFVSAIFLAEFSHRKAHDFLKLIFELMAGIPSVVLGSFGLKYVSRWLMELFPMKVWTGLNIFNASLMLSILAMPYFVTLIEDALKAVPVDQKEASLALGANTTSTVFRIIVPQARSGILNAIILGANRIIGETMVVLMVAGGASMIPQSIFDPVRPLTAAIAGEMGEVELGSTHYYALFMIGIVLLGISLIFTVIAMRLKRGMRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V1</accession>
    <name>I2F6V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PLP-dependent enzyme possibly involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731438.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2011"/>
    <dbReference type="EnsemblBacteria" id="AFK07654">
        <property type="protein sequence ID" value="AFK07654"/>
        <property type="gene ID" value="Theba_2011"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2011"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_0"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="43590" checksum="50A49A485FA74D80" modified="2012-07-11" version="1" precursor="true">MFVPLSRPDITEREISAVTELMTGGILSIGPKVTEFERIFAEYIGVEHAVAVNSGTSALHLVIRSLDLKRGQTVITSPFTFVSSANVALYEGAIPIFADIEESTFNVSPETLEEALANYSRDGLDTGAIKLDPFVPDIFMAVDIFGHPLEWDRIEGICNKHGIRIVEDSCEALGSSFMGRKTGSFGLAGTFAFYPNKQITTGEGGMIVTDDSNIAELSKSMRNQGRGVSENWLEHVRLGYNYRMDEMSAALGVEQMKRIDEILEKRQRVADRYERLLSNISGIETPFIANYATSIGWFVYVIKLDEKIDRESFMRYLTENGVQCRDYFRPIHLQPFYMQDFGYREGMFPVTERLAKRTVAIPFFNNLSEEEMQFVSYTIEKAVEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W1</accession>
    <name>I2F6W1_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731447.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07664">
        <property type="protein sequence ID" value="AFK07664"/>
        <property type="gene ID" value="Theba_2021"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2021"/>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064094_1_0_0"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="83"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="221" mass="25261" checksum="4D65CF6099883864" modified="2012-07-11" version="1">MELHKSTIAYSLKRKLDYLLSLPLQYNEEDTEWPLILFLHGAGERGDNLELLKKHGIPRVVSEMSDFPFITVSPQCPENDWWLNRLQDLRFLLESIIKQYRVDHSAIYLTGLSMGGFGTWHMAVEYPDLFSAIAPICGGGLGILGFPERVIDIKDLPVWAFHGEKDNIVSVEESRILVKTLKEAGGNAMLKIYPDAGHDSWTETYSDPELYEWFMSKRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y0</accession>
    <name>I2F6Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07683">
        <property type="protein sequence ID" value="AFK07683"/>
        <property type="gene ID" value="Theba_2042"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2042"/>
    <dbReference type="HOGENOM" id="CLU_3365834_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="35" mass="4029" checksum="15C04C1DF8DB4FE3" modified="2012-07-11" version="1">MTMRAYVPATVSLNRVSGDAVLCHAFFRRVRYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y3</accession>
    <name>I2F6Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2045"/>
    <dbReference type="EnsemblBacteria" id="AFK07686">
        <property type="protein sequence ID" value="AFK07686"/>
        <property type="gene ID" value="Theba_2045"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2045"/>
    <dbReference type="HOGENOM" id="CLU_3235862_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="43" mass="4789" checksum="37D77BC7FCE53E62" modified="2012-07-11" version="1" precursor="true">MNEAVSKSIMIFVEGYPTMFLATVAFFIMIKLLMKSASRKDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z6</accession>
    <name>I2F6Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731478.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07699">
        <property type="protein sequence ID" value="AFK07699"/>
        <property type="gene ID" value="Theba_2061"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2061"/>
    <dbReference type="HOGENOM" id="CLU_1203691_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="230" mass="26199" checksum="FA88CFBFA082A810" modified="2012-07-11" version="1" precursor="true">MNIRGFCLIIFLILTASCFANLEMKVDSGVSMPWSGFLEVSDSERTQLLMKNDFRAYFLPTVGYEISGEHLIELSFFHFTVKSTFEATDTEPLASYESMFKQDVLSLTYMYILPELDRFSLQLGVQGRLWFKQLTLIGSKTFDRKVSDLSFGPAADLRLQMNDKVFIGLDVSTGLGKGNGFIDMFAGLHFEGPFYYVRAGTRYWSVTNSFDNDRFFLSFVNLGVQFCAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F792</accession>
    <name>I2F792_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2162"/>
    <dbReference type="EnsemblBacteria" id="AFK07795">
        <property type="protein sequence ID" value="AFK07795"/>
        <property type="gene ID" value="Theba_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2162"/>
    <dbReference type="HOGENOM" id="CLU_3137544_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="49" mass="5824" checksum="E72279909CFD364E" modified="2012-07-11" version="1">MKTLFKRRMEIMGQIRINMIRYPIPLCIDGSFCITNTVSQYVLKKTSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B8</accession>
    <name>I2F7B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07821">
        <property type="protein sequence ID" value="AFK07821"/>
        <property type="gene ID" value="Theba_2188"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Peptide/Ni-bd"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="394"/>
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            <dbReference type="Pfam" id="PF00496"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="489" mass="55510" checksum="E01FBF6D8CCC9787" modified="2012-07-11" version="1" precursor="true">MRRIGLMLMLLIVAVTALLSQRIVVAVMQDPDFLDPHRAAASGTYEMMFNVFEGLLKPNPNGTVIPAIAESYSISEDGMVYTFNLRSGVKFHNGSEVTVDDVLYSLNRLKGSNGERGLSPDFEKFVSKIEAVDDKTVRVKLSTLNTDFLEKFIVAIIPESNENHEKNPVGTGPFRFVEYRPGQRLVIEKFEEYWNPELPKVEEVEFRIIPDNQAAIMSFLAGEVQILPRLDAIQAMALGDRYNLLTAEQNMVQLMAMNHAVSPFDDIRVRRAINHAVDKEEIIEIVAGGYGTKLGSNMSPIMSAYYREGLEDYYEPSVEKAKALLSEAGYPDGFDTKITVPSNYQFHIDTAQVIAEQLKRVGVRAEIELVEWSVWLDRVYTAREYEMTIIGLTGKLSAYEILRRYVSDYPRNFYNYSDSEYDRIISLAIEKTAVEEKASMFKRAQEILTEDAAAVYIMDPNFIVALAPNLHGYTVYPLYVQDMSTLYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D8</accession>
    <name>I2F7D8_9BACT</name>
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        <submittedName>
            <fullName evidence="2">PAS domain S-box</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">Theba_2209</name>
    </gene>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="466" mass="54035" checksum="F3F22017E5A05297" modified="2012-07-11" version="1">MFDFYSKPRIILVGRSQKDARRLIEAFDERFDVRYVEEVSDEYSRFSDAMVFDYVGEDIIRNLRSGSIPYLCLIGSEKAIVKYSLEPGEYLLKGPGYLHYLPEIVYSMLEKHRLQKTLDFEREKYMGLVNSMGCGMLILRKRDGNVIFCNQVAQSLLGYTEEEIEKMRLQDLVYDEPFALETILGIEHFDTDREIVMLTKTGGKTYVIFNTSEMLYGAESVVQLTFMDVSKQKRDREELIFQWRFLDNAEEIAIAIDEKGRIVYLNKFAAEIHGYDLEEMLGDNLASYLVQGEGEAESMQFSMMKSGKWKGRQLHRRRDGTEFIVEAKRSMLRVDDNVYELVIGIDITENIELQRRNNLHSLLLNGTGDLAIATDMKNRLIYLNEAAEKYFETRLEDEENKALEDISSEPLRNFLKIAASKPSEPLENKIRFPVRQESNAVIEFTGEIVRDHDEEVGTIFIGRKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F4</accession>
    <name>I2F7F4_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">Theba_2227</name>
    </gene>
    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFK07857">
        <property type="protein sequence ID" value="AFK07857"/>
        <property type="gene ID" value="Theba_2227"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="YdjM-like"/>
    </dbReference>
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    </dbReference>
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            <end position="90"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="134"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK07857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="207" mass="22650" checksum="70C49DED25A54A0A" modified="2012-07-11" version="1">MAVRKMADFKTHIYWGIASYPIFTLLSLSAIELLPVQQLQDSSLIGSGYLLYVLGSDLPDIDSKSALIKRIIEILIASFVASALYISIISPRVQPFLLSRLPSLPVAVTLSFSLAIISGLVVSKLTNLLSHRGFFHTVWGSLLYGLVIESVVIFKLESFGGSMNHTETIFLGIAGSSGYCLHLLLDKIHGVKRTRRSDPGQESNTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I3</accession>
    <name>I2F7I3_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative membrane-associated, metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="660470"/>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2257"/>
    <dbReference type="EnsemblBacteria" id="AFK07886">
        <property type="protein sequence ID" value="AFK07886"/>
        <property type="gene ID" value="Theba_2257"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2257"/>
    <dbReference type="eggNOG" id="ENOG502Z8W3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="727832at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011435">
        <property type="entry name" value="UmpAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07556">
        <property type="entry name" value="DUF1538"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="496" mass="52383" checksum="117E38A18E4B6820" modified="2012-07-11" version="1" precursor="true">MNLLLEKLKEVLLAVLPITVLVLVLNFLFVSLSWFLIFRFVIGSFLIVVGLSAFLFGVSIGISPIGNFMGTFIAKTNKLWIVAVAGLVLGFFISIAEPALHIHALQVELVSSGILSSGSVVITASIGIAVFLSLGLIRIVFNVALKKLMTVSYGIILILSLFSSRELLAISFDASGATTGAMTVPFILTLAAGISVLKRDSRSSENDSFGLLGIASAGAIISVLLVGIVSTNNTMEAAPVYFASESSEILGYFFDLMPRIASEVLLSLLPILLAFLLLQFSSLRLSKRVLRQITVGLVFTFVGMVIFLVGVNGGFMDVGREIGYGIASMGNKSILVLVGMILGLVTILAEPSVYVLTHQIEDVTSGAVKRRIVLLALSAGVSLAVALSMIRIAVPAVQLWHFLLPGYAISILLSFFSPKLFVGIAFDAGGVASGPMTGTFVIAFAQGAASAIEGANVLIDAFGLISMVAMTPIIALQILGLIYKIKTRKRGVESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K5</accession>
    <name>I2F7K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2280"/>
    <dbReference type="EnsemblBacteria" id="AFK07908">
        <property type="protein sequence ID" value="AFK07908"/>
        <property type="gene ID" value="Theba_2280"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2280"/>
    <dbReference type="HOGENOM" id="CLU_3404331_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="30" mass="3322" checksum="8D564473FF46EC4E" modified="2012-07-11" version="1">MKKNAGVLYDRDVVSACVQIIESGFTFESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K8</accession>
    <name>I2F7K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487578.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2283"/>
    <dbReference type="EnsemblBacteria" id="AFK07911">
        <property type="protein sequence ID" value="AFK07911"/>
        <property type="gene ID" value="Theba_2283"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2283"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="119"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="36174" checksum="ABEE3D9BD3A32E59" modified="2012-07-11" version="1" precursor="true">MFRDVFSLFIENRKALIGLIILAFFSIVAIFAPLIAPYDPKTNKVEVLSIVEEEIGRTKTVEREEIDEFTEKRVYTQSITTTYEKVTTKLPLNAKPSRNHLLGTTRAGQDLFSQMVYGTRITLAVGLITGLFTTLLALTLALVAGYFGGIVDDIISLFTNVFLVIPSLPLMIVIAAYITVKGVIPIVLILGLTSWPWPTRILRSQVVSLKNRDFVRVSRILGERPLYIVFREILPNMISLVMASFFTSTMAAIMGEATLEFLGLGNVSVVSWGTILYWAQNSGALLSGAWWWFLPPGICIALIGTSFALMNFAIDEISNPKLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q9</accession>
    <name>I2F7Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731712.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2337"/>
    <dbReference type="EnsemblBacteria" id="AFK07962">
        <property type="protein sequence ID" value="AFK07962"/>
        <property type="gene ID" value="Theba_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2337"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_0_0"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="148" mass="16732" checksum="5861AAF140D59AA8" modified="2012-07-11" version="1">MSHDLSFSGEGYISRWIYCISRSANVYFSREMQKYGLGSGHFFFLRVLMSKEGISQNELSDILGVDKATTAKAMSKLTEAGYVKRDIDSLDTRVYRLFLTDNGKKIGQKLRKLGSELEEILTEGFSDDEKQQLLSLLERAATNAKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X0</accession>
    <name>I2F7X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+/H+ antiporter subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731764.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2406"/>
    <dbReference type="EnsemblBacteria" id="AFK08023">
        <property type="protein sequence ID" value="AFK08023"/>
        <property type="gene ID" value="Theba_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2406"/>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2436976_0_0_0"/>
    <dbReference type="OrthoDB" id="2098734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10094" checksum="1CFC74EABD33EBBC" modified="2012-07-11" version="1" precursor="true">MMEIIAYIILIPGLFFVVAGTLRAVFAHTIIGTLHFLTIADTVGLIFLVISAFFFGLLTIIEMLAFIVALMVTGPLVTHVIARAFINSGGREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F819</accession>
    <name>I2F819_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent enzyme, D-cysteine desulfhydrase family</fullName>
            <ecNumber evidence="7">4.4.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2461"/>
    <dbReference type="EnsemblBacteria" id="AFK08072">
        <property type="protein sequence ID" value="AFK08072"/>
        <property type="gene ID" value="Theba_2461"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2461"/>
    <dbReference type="eggNOG" id="COG2515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048897_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005966">
        <property type="entry name" value="D-Cys_desShydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01275">
        <property type="entry name" value="ACC_deam_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="7"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="320" mass="35631" checksum="615FDEBFAE811162" modified="2012-07-11" version="1">MKLKFINGVTPVNRLEWIEEYLGLPFELFCKHDELTGFITSGNKIRKLEYLLKDALEKKADTVFTCGGIQSNHCRATAMAARSLGMQPVLFLRGRPMEIPQGNVLLDTMVGSDIHYVTKEEYSRIDEIFAKKKEEYENKGRKVYLIPEGGSNALGARGYVDAVKELSGQINLDGVEAIFTAVGSAGTYAGILAGLRILGYNTGVIGINVTKDPSSIFVEKTKRLIGEMREYEIDVSIDDGEIEIVDDFSGPAYAVPSEEDIELIKSLARERAFFLDPVYTAKAFRGMLQISRERFAGKRVVFIHTGGLFKLFDNPATYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>I2F863</accession>
    <name>I2F863_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">Theba_2508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731848.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2508"/>
    <dbReference type="EnsemblBacteria" id="AFK08116">
        <property type="protein sequence ID" value="AFK08116"/>
        <property type="gene ID" value="Theba_2508"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2508"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_0"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="47"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="31967" checksum="6F4641AB4BE05EBB" modified="2012-07-11" version="1">MKEKPDWLKKKLNADRSKLSEIKVMLRSLRLHTVCEEARCPNMGECFASRTATFMILGNICTRNCRFCAVSKGIPGSPDPKEPENISHAVHLLQLRHAVITSVTRDDLNDGGASQFVDVVRELRKNCPNTTIELLIPDLNGNWKALERIVREHPDVLNHNIETVPSLYANVRPGATYERSIGLLRRVKEIDSSIITKSGIMVGLGEREDEVKSVIKDLSDAGCRMLTIGQYLQPSHKHLPVVEYITPEQFEGYRIFALERGFSFVASGPLVRSSYHAALGFSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F869</accession>
    <name>I2F869_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08122">
        <property type="protein sequence ID" value="AFK08122"/>
        <property type="gene ID" value="Theba_2514"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2514"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_5_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="13"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="23914" checksum="D78357296B94216A" modified="2012-07-11" version="1">MFLKEGQRVLFQGDSVTDTDRDREDFFSLGDGYPAIISGLLGSAHPELRIEFLNRGVGGDRVRDLRRRWEVDCLDLSPDWVSILVGINDCWRLYDSNDKTEPENFESDYRYLLKSVRSKGASVIIMEPFFLPVFSGMERWTEDLGPKIQIIRRVAREFKAIYLPLDGIFAAAAARREPEFWAEDGVHPTPEGHALIARYWLQAMNITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F877</accession>
    <name>I2F877_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489552.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08130">
        <property type="protein sequence ID" value="AFK08130"/>
        <property type="gene ID" value="Theba_2526"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2526"/>
    <dbReference type="HOGENOM" id="CLU_192689_0_1_0"/>
    <dbReference type="OrthoDB" id="2027977at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="61" mass="6733" checksum="BDB4DFD2E97CC790" modified="2012-07-11" version="1">MIRTDKCPNCGSLDIGKGYWSGYAALMPLGKPLSMGSKVIVRVCRECGHIFDLQAEKPDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E2</accession>
    <name>I2F8E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2595"/>
    <dbReference type="EnsemblBacteria" id="AFK08195">
        <property type="protein sequence ID" value="AFK08195"/>
        <property type="gene ID" value="Theba_2595"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2595"/>
    <dbReference type="HOGENOM" id="CLU_2633987_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="8333" checksum="F8B2D921EA0E7351" modified="2012-07-11" version="1">MCTHPVDDGAVDTPLESSSLPTSSSSELNHFAPQFQNQLALVVNNDGFMDLYVLDLKSPLERGGPLAVGCVLFEQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H0</accession>
    <name>I2F8H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489399.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2623"/>
    <dbReference type="EnsemblBacteria" id="AFK08223">
        <property type="protein sequence ID" value="AFK08223"/>
        <property type="gene ID" value="Theba_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2623"/>
    <dbReference type="eggNOG" id="COG3877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132137_0_0_0"/>
    <dbReference type="OrthoDB" id="1943427at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018658">
        <property type="entry name" value="DUF2089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09862">
        <property type="entry name" value="DUF2089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="124" mass="14344" checksum="F95AB598360403FF" modified="2012-07-11" version="1">MKYSISNCPVCGGKMTITEYKCDSCGTTIRGRFELDDIMKLSAEQLDYLKTFIKNRGNLSEVQKELDISYPTARNRLEDIVRAMGYQVVDKDREEASRILERLESGELQPDEALEMLRKVRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I4</accession>
    <name>I2F8I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731944.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2637"/>
    <dbReference type="EnsemblBacteria" id="AFK08237">
        <property type="protein sequence ID" value="AFK08237"/>
        <property type="gene ID" value="Theba_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2637"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468285_0_0_0"/>
    <dbReference type="OrthoDB" id="145977at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="588" mass="66537" checksum="97F9A567D2B8054F" modified="2012-07-11" version="1">MRSILINGEVAYNAPSQIFNSVTFREILAELINDSEEKKNSLLSLFEPFLRNTDTMETSRKYDIDGIVELLLALTIDPIEKIDGSSYYSFPKMSNKRELLVRFVESLFSLWRNKHRFIVKRDEYTPNRFDRIFKQMVLVRTNTDLKSLVLSLYRQILINVSDIRLKILRQEPGGAQVGFIVDNPEVDKRARVPGADWLYGMACVWSIVFEPPVIFYTRSNKRHGLFEVRDKPILSKLNIPSSNDWFLFPIHVGSKLIDVVVNKEYLSLAAGLGNLFELASFDIVKNKKPDGIYILGIDNSFFEKKEDFNGVIYREDDGTYIGIVGDDPSIDYFGYMKKMILTIHNLLVIDEGRLPVHGALAHIKLRNGKKANVMLIGDSGAGKSETLDALNRLHAEVSEVNILIDDMGSLDITSSGSVIAYGTETGAFVRLDDLQPGYAYSTMDRSIFMNPNEINARVIVPYSNYTDIIKPTKVDYFLYANNYNEDKDSDLRIFKDAEEAAAVFSNGARMAKGTTTEKGLTYSYFANPFGAIQRRERHEVIADRYLKAMIDSGVRVGEVRTRLGIPGYEMEGPLMAAKALLKAIDEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K3</accession>
    <name>I2F8K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na+/H+ antiporter NhaD-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_2657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487262.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08256">
        <property type="protein sequence ID" value="AFK08256"/>
        <property type="gene ID" value="Theba_2657"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2657"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_0"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK08256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="46746" checksum="82FDF11A04220369" modified="2012-07-11" version="1" precursor="true">MGLMDRIFIVVYFILTFILIVLSKRRRVLIAFTAGMMLVALKVSESMRIETISQFVDFNAIFLLIGMMVIVAVIKSTGFFQYVAVRTLKATKGNILLLSVLFSALIAAFSMVLDNVTTMIMFMPIIFFVADTAGFNPFGFTAVMILASNIGGCMTLVGDPPNIIIGNASKIPFLTFTSLVFIPLVLTYIVLMLISRFKILRGLSSISDKKDEIQGLKLDGVITNRKLMYVSLGTLIVVVIGFAVHSIVDIEMSLFAVLGAAFLLLYTGKDFESVANEVDWNAILFFIGLFSLAYSLESTGITSELSDLALGLSSNPAVLSMLILWVSGMIAMVTGAIPVVTIFIPIVAELSVHYPLQYDLWIALALGANLGGNGTVTGHLANVMCFEMVNKEYGNTHSFLDFMKIGFPSSVISLAISSLFLIIRLVIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N5</accession>
    <name>I2F8N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type branched-chain amino acid transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731983.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2689"/>
    <dbReference type="EnsemblBacteria" id="AFK08288">
        <property type="protein sequence ID" value="AFK08288"/>
        <property type="gene ID" value="Theba_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2689"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_2_2_0"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="320" mass="34656" checksum="A90C37CAC5008296" modified="2012-07-11" version="1" precursor="true">MKKTIFVIGAILLIILFPLFVKNSYHLYLMNRALIHAILATGLVFLTGFAGQISLGQAGFYAIGAYSSAYFTVKLGMPIVVGIIAGIVISVIAGFLLSIPSFKLKAFFLSLVTIAFGQIVWMLVINLTPITGGPYGFFGIPFYSFGGVMLSFGQVFWLFGGLLLLSVFIMFRIKHSHFGRAMLAMNDDDVATETCGISTKKLKIAAFGFSAGLAGLAGALYAHLAGFLSPEPFTFFESSNFVAMAVVGGLRHMSGGVVGGIGLTLLPEFLRFGGWENYYLMVTSLIVIVIVIFMPMGLGPILESLFRKVFRVKRNNTKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P9</accession>
    <name>I2F8P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08302">
        <property type="protein sequence ID" value="AFK08302"/>
        <property type="gene ID" value="Theba_2703"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2703"/>
    <dbReference type="HOGENOM" id="CLU_2180729_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="109" mass="12487" checksum="2E5C7526E900435F" modified="2012-07-11" version="1">MLRLRSYLVDLERHLAKDRHRNFFLSNDMAITENSPVGLCFEDIYSGSVFLNRGARESGLRVSDSVSYPGGESFVEFVKSENFERCFRSMVIDNDEKVSGLDVRNSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S1</accession>
    <name>I2F8S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_2729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732017.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2729"/>
    <dbReference type="EnsemblBacteria" id="AFK08324">
        <property type="protein sequence ID" value="AFK08324"/>
        <property type="gene ID" value="Theba_2729"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2729"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_0_0"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="8"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="382"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK08324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="627" mass="72196" checksum="9736A15925AFB616" modified="2012-07-11" version="1">MNWFGAAYYPEHWPRERWKKDVRTMGEIGINVVRIGEFSWSVVERKRGEIDFSVLDEAVDLLNSEGIKVIMGTPTCTPPPWLTKEFPEILQKDVNGLVIASGSRRHYCFNSKIYREETSRIVEAFADHFGNDPRIVAWQIDNEFGCHNSTVCFCENCAVAFRDWLKKKYGSIDKLNKAWGTVFWSQIFNDWEEIEPPRRTLTSPNPSLVLDYRRFSSDSAIDYHNLQREIIMRKSEAPITHNLMVNFTEIDYKKLSDSIDFVSWDNYIVGDYDPDLQALNHDLMRSLKKQPFLVMEQQPGRVNWRAVNPSYESSQLSFWVKQSFAHGAFGSLIFRFRQLPFGSEQFHTGLIDYDGEPTERAQAFSKAIEKLTDWSVVVPQREAAIYIDYENFWINDTDNLNNKFDLLIDGILPVYKSVRSLGYNVDFVFPGDSLEGYLLAFVPSSFKLERCFVEELRKFKGDIFFTALTDQKDGRNFIRKTEESFITELMGLRVVDAGGIETKVEISFADHVFNGSFVVEKILPSEDCEVLAVYLNGPFTNHPALIKRANMYYLSTVPEIVSFQTLLIEAGIERKASGPGRVIKGESNTILQNPFPHSITMEVGGKDYTLNEYEVRRVQTGLSKNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E0HXU0</accession>
    <name>E0HXU0_9BACT</name>
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        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_1809</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1809"/>
    <dbReference type="EnsemblBacteria" id="AFK07460">
        <property type="protein sequence ID" value="AFK07460"/>
        <property type="gene ID" value="Theba_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1809"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125830_0_0_0"/>
    <dbReference type="OrthoDB" id="1595913at2"/>
    <dbReference type="Proteomes" id="UP000002881">
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="165" mass="19308" checksum="A1972AC12812E5A0" modified="2010-11-02" version="1">MSDFKSILEVALSFEKSGREFYKNNMQKVNQSVAKKTFEYLMEMEDSHVKFIEGMIEALEDNKEVDFALQEEAEEIFVERLESQALSNNSYSSDLADLSILRMAYLIERDFVDYYENASKNVEDTSAKKLMVKLMNWEKGHVTLVKDLMEKIYEKNAIDLGFYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1F6</accession>
    <name>I2F1F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729942.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0002"/>
    <dbReference type="EnsemblBacteria" id="AFK05759">
        <property type="protein sequence ID" value="AFK05759"/>
        <property type="gene ID" value="Theba_0002"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0002"/>
    <dbReference type="HOGENOM" id="CLU_2936260_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="60" mass="6462" checksum="3C9E30E78F31808C" modified="2012-07-11" version="1" precursor="true">MKYAVSFLLFLVSAATIIGTVSDSQASRLRESMNEKSGVFPNMVDGVFAVSEEGKNEICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L7</accession>
    <name>I2F1L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0069"/>
    <dbReference type="EnsemblBacteria" id="AFK05820">
        <property type="protein sequence ID" value="AFK05820"/>
        <property type="gene ID" value="Theba_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0069"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="73"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="333" mass="36287" checksum="6B4C1F314EE0AA74" modified="2012-07-11" version="1">MAVGISLDNLAASVANEGGIGVIGTAGIGMTVEGYRKNFRQASIDGLRNTIRRAREKTKGVLGVNIMVALTNYAEMVATAVKEKIDVIISGAGLPLDLPSYLEEGSETAIIPVVSSLKSATVIFKRWFSRYKYIPDGFVVEGPKAGGHLGYRVGEIFSEESSLEKTLPEIRRFVDQVKRDTGKNIPVIAAGGIFDRDDVERVFKLGASAVQVGTAFVAAEECDADYRFKQAFVNARSEDITIIKSPVGMPGRAIRNKFIEDVEEGKRKPFKCAYQCIKTCNYREAPYCIAEALMNACKGDLENGFAFCGSEVHRISGITTVKKVIDRLFGEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N4</accession>
    <name>I2F1N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730010.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0087"/>
    <dbReference type="EnsemblBacteria" id="AFK05837">
        <property type="protein sequence ID" value="AFK05837"/>
        <property type="gene ID" value="Theba_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0087"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="212"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="428" mass="47779" checksum="38DE7B1AAFF804AE" modified="2012-07-11" version="1" precursor="true">MKSVTGEGLSFRKAKRRWTLFFTLIVVSLVSVLSLFIFVLSLRLERGAEITALNRVADRIESRIGRAPLIALERMLRNYSGNLDLFTAENEILEFVTPDGESVLQLGGRIKSSVPLVEGTSKAKVVDYDDSELEYNILTRAIRNIAGQPVFFLRVGRSIEGLSEKSTSLLFSLILLIVLVAAISWIVGLALAGYVLTPLRESYDRLQRFTADASHELKTPLTVMRLSVDLLKSRPLESESRDKIDAIDGATRSMQNVVNQLLLQAKANNDSSAVISYQDVRVREFLEEMKEYHRTFAESKEVRIILESDEDLFVRTYLDKLKVAVAAVLENAIKFTEEKSDVTVKAFEREASLLIQIGDSGPGIDDPDKERIFDRFYKIDESHNSSGSGMGLSIAKEMIGSLGGEITVENRPGGGSIFEIRIPSRKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F201</accession>
    <name>I2F201_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730116.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0220"/>
    <dbReference type="EnsemblBacteria" id="AFK05954">
        <property type="protein sequence ID" value="AFK05954"/>
        <property type="gene ID" value="Theba_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0220"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946306_0_0_0"/>
    <dbReference type="OrthoDB" id="1881506at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="259" mass="29209" checksum="20B609929A1294A8" modified="2012-07-11" version="1">MFSEAFRIASQFTRPVVVLTRNGAGEVVANCGSFIVLNREGWIVTMAHLWHSYFMFKQQHNQNNIEPAKRIENHSFWWGGDGKVLKDIRPFPEDDLVIGRLEPFDPDEIVEYPAFVTQDEMKIGTSLCRVGYPFSRIRASFDEKNSRFIMDGKSLPSLYPIDGIYTRTVEAPAFKGAKNMTKFIETSSPGLLGQSGGPILDTKGRVWGVQSRTVHLPLGFSPKVRRDGREIEENQFLNAGWGVHAERIRDALGSSGRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F243</accession>
    <name>I2F243_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent phosphoesterase, PHP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730154.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0263"/>
    <dbReference type="EnsemblBacteria" id="AFK05996">
        <property type="protein sequence ID" value="AFK05996"/>
        <property type="gene ID" value="Theba_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0263"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067347_1_0_0"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="280" mass="31179" checksum="1DCB52004AB73865" modified="2012-07-11" version="1">MFVDFHCHSDHSDGTDSVAAIVQKAANKGISILSVTDHDTLAGQNEARELCLRAGIKYIRGVEISCDFHETLDVLGYGMVFEASSMEEELRQLRLKRDLRNTRILSRLRSLGVQITDEELESSFPGESLGRPHIANLIVRKGYSDSTENAFKEFLGKDGKAYVEKEKLSIKSAIELILSAGGVPVLAHPLSMMLDRKETIEIIRAMIRYGLKGMEVFYKTYEETTREELFEISGNLGLIATGGSDYHGKHKKHLELGIDIPDSAVSRFLESLPADNGLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F297</accession>
    <name>I2F297_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730192.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0320"/>
    <dbReference type="EnsemblBacteria" id="AFK06050">
        <property type="protein sequence ID" value="AFK06050"/>
        <property type="gene ID" value="Theba_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0320"/>
    <dbReference type="HOGENOM" id="CLU_1813531_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="142" mass="15739" checksum="CE637E4CB040C845" modified="2012-07-11" version="1" precursor="true">MRGIYIFLGNLLMFVAVVIALLFGGGQIVNSVLEGKSIDIGIMDFLFPITLFVTGFFLQYCSLAKRIALPVLEELLLAATLVLYIRESLAGGFTWWLLPLRDYIPSSLLFTIIGYLLPGIVVFTMAALIVLMIMISGEKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A3</accession>
    <name>I2F2A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730198.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0327"/>
    <dbReference type="EnsemblBacteria" id="AFK06056">
        <property type="protein sequence ID" value="AFK06056"/>
        <property type="gene ID" value="Theba_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0327"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_7_2_0"/>
    <dbReference type="OrthoDB" id="783542at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="2">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="372" mass="42572" checksum="3914F0283DAF113F" modified="2012-07-11" version="1">MLEAVREIWFVEGTTYIKICYGNVFVDGEAGQLGDRGEVDSFKIKSVKKIGDEVVLEIDGKIEKNKGEMVDIRIDEERRIDISQQHTAQHLLSAVFLSEMDAETVGFQMGEEYTTIDLSLGILKDDMIDYVERLCNNFIGEDRAVRKFVVDRSEIQKYHLRKEIKREITESEREIRLVEIDGIDLSACSGLHVERTGQIGLLKILKHEKVKGSLTRVYFVAGKRALNDYFTKHKLITNSSLLLTCSYLDLTDRIASLIDEIRQDNSKIRSFSERLAGYVAREINGSKSRVIFLEDEESILASIPRFVTLEEYLIIGKSDDRILLFCKGYDCREVLTRIKKEFDVKGGSGKERGQFVFDGEFASIKELIENSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A5</accession>
    <name>I2F2A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491897.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0329"/>
    <dbReference type="EnsemblBacteria" id="AFK06058">
        <property type="protein sequence ID" value="AFK06058"/>
        <property type="gene ID" value="Theba_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0329"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="253" mass="27904" checksum="20E8F629D7FD5C96" modified="2012-07-11" version="1">MIEARNLTRKFGTLVAVDRLNLNIASGEIYGFLGPNGAGKTTTIKMLTGIISPSLGEIFIDGLDMQKDLMEIKRLISVVPDEPKMYENLKGLEFVKFIIDVYRLPVKETLKKLNNLAEAFKIDYLGKYIGDYSHGMKQKLMVAIALMREPSVVFLDEPTVGLDASSAGKLRILLRNMADNGTTVFMTTHVLEVAEKMCDRIGIIDSGRLIAEGTLSDLKESFGRAESSLEELFLDITGDGETKLSIEGFEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A6</accession>
    <name>I2F2A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0330"/>
    <dbReference type="EnsemblBacteria" id="AFK06059">
        <property type="protein sequence ID" value="AFK06059"/>
        <property type="gene ID" value="Theba_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0330"/>
    <dbReference type="HOGENOM" id="CLU_1466576_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="184" mass="20672" checksum="04B61F98D31BA59E" modified="2012-07-11" version="1" precursor="true">MRLLLVQESLIGMLAVSMFFWSASLSSAVLLIAIVLGLLVYRPELENKIVSKDSLLEMVRGVLKRPLTMVLIVAIIVLRNPGAYSILAIISSICLVTSLASVSFLIFKELRRIRENVLAIFITVASIISGWLFSDFLSAPFFSGKFLPSFWIFKISEGDLVGFLMVSVLSIWLFRMRHRLDKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C4</accession>
    <name>I2F2C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-associated heat shock protein implicated in recycling of 50S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491924.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0348"/>
    <dbReference type="EnsemblBacteria" id="AFK06077">
        <property type="protein sequence ID" value="AFK06077"/>
        <property type="gene ID" value="Theba_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0348"/>
    <dbReference type="eggNOG" id="COG1188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101003_4_1_0"/>
    <dbReference type="OrthoDB" id="2006597at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="79" mass="9194" checksum="E77728352BBC0B99" modified="2012-07-11" version="1">MRIDKFLKMNGIIKRRVVAKQAIEKGYVFRNKIRAKPSSEVEPGDLVSVRFFNRVLVVRVKEGFESEIVEETRVESPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C8</accession>
    <name>I2F2C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate formimidoyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730216.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0352"/>
    <dbReference type="EnsemblBacteria" id="AFK06081">
        <property type="protein sequence ID" value="AFK06081"/>
        <property type="gene ID" value="Theba_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0352"/>
    <dbReference type="eggNOG" id="COG3643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040037_0_0_0"/>
    <dbReference type="OrthoDB" id="780971at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="SSF55116"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FTCD" evidence="7">
        <location>
            <begin position="180"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="304" mass="34107" checksum="FB1B993BBCF8578E" modified="2012-07-11" version="1">MRLIESVPNFSEGRRLDVVERIVEEAKKIEGVWILDYSSDPDHNRSVITITGEPEAVEAALFNMTLKAKELIDLNNHSGEHPRMGATDVIPLVPVMNVTKEECIALSKKLGKRIGEELRIPVYLYEDSASTPERISLSNIRKGEFENFASKIASDQWKPDFGPSEIHPSAGVTAVGCREYLIAFNVNLGTNKIEIANKIAKSVRHISGGFRYVKALGFKLEDRDIVQISMNMTNYRKTPLFRVFEVIKSEAERHGVPIVGSEIVGLTPLQALVDVADHYLRLEKFTSSSILEKKVLDFIADKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J0</accession>
    <name>I2F2J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730258.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0415"/>
    <dbReference type="EnsemblBacteria" id="AFK06143">
        <property type="protein sequence ID" value="AFK06143"/>
        <property type="gene ID" value="Theba_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0415"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1711085_0_0_0"/>
    <dbReference type="OrthoDB" id="1949550at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="16703" checksum="ACC9669A0BF994BF" modified="2012-07-11" version="1">MYSCKIIRVLESGFFDEIAQSIEISKKILESHGITYTGSTDVDPVMSDLKEAIYSDSCSNDIVLVLGGTGLYKEDIGPEVVLSLVDKRATGIETAMLRNAIVADPSLCLYRVGAGTIGDSIVLSVPGYHETVHYYLEPVIDYLKPFFDGLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K9</accession>
    <name>I2F2K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730277.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0435"/>
    <dbReference type="EnsemblBacteria" id="AFK06162">
        <property type="protein sequence ID" value="AFK06162"/>
        <property type="gene ID" value="Theba_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0435"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_0"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="138"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="40101" checksum="14D1F9F815390623" modified="2012-07-11" version="1" precursor="true">MARKDKLSLAQKEQRTAYKLLIPALLILALVAFYPLFQVFYTSFTDKVFASGTDEAPKLIGFENYKSLLGLTVMELPKVVDETTGEASIDEETGKPVYERAIRVLPRSPVRYREWFQFSLFGRRYVVGARDPEFMKAISNTLVFAVISVFLETVLGLGVALVVNSNFKGKGIMRATMLVPWAVITVVSARIWEWMLQPTRAGLFNAVLSKLGWGDGDLSFLSMPALQMPTLIAVDVWKTTPFMALLILAGLQLIPRELYEAARVDGAGRLKQFLSVTLPLLKPTLAVALIFRTLDALRVFDVFQVLMGNRMYSMASYNYYQLIGNRNMGLASAIGVIIFFLIGIFAVIYMRLMGVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M8</accession>
    <name>I2F2M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartyl/asparaginyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730295.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0455"/>
    <dbReference type="EnsemblBacteria" id="AFK06181">
        <property type="protein sequence ID" value="AFK06181"/>
        <property type="gene ID" value="Theba_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0455"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_2_0"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="35881" checksum="3FB492D7F3F2C7CB" modified="2012-07-11" version="1">MESIGRLSSRVLEHLSDPVVKSAVKVKSAILGEASSFLRGKNFVELLPTIVSPITDPLNHEVHTTRFTYYDQEYRLTQSMIFHKQLACKSFERIFIVSPNVRLETSEKALSGRHLFEFSQIDLEIRNAKREQIMSLIEDLIITVMLSVKRNCSEEMDFLSSDPSIPSKPFATVKFMDAYEQYGKDFETILSASFSEPFWLIDFPIWEREFYDLLSEDKRTLKDMDLILPHGFGETLSGGEREWEHQRILERMGFKGNDPEELSWYMDIAEGGELVPTAGCGIGVERLTRYVCSLDNVSRTRLFPKVPGQSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P3</accession>
    <name>I2F2P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730309.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0470"/>
    <dbReference type="EnsemblBacteria" id="AFK06196">
        <property type="protein sequence ID" value="AFK06196"/>
        <property type="gene ID" value="Theba_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0470"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="421" mass="47047" checksum="F6DBD65F21BDD521" modified="2012-07-11" version="1" precursor="true">MRKRLILALLIVSFAVFTFAVTEIEFWHAMGGAQGTTVNEIVASFNEANPDILVKAIYVGNYSALQQKLLVSAESKTLPALSQAYGNWTARLIPRDAVQELNSLISDPEVGLTDEEWDAIWNPFKKMVTWGDTVYALPFNKSTYVLYYNTDLFEQYGLEVPKTMDDLLFAAMMLTEDKNNDGQIDQYGFGFRTTIDHFMIFLRANGGEAIDIKPDGSVEVTINSPEAKEALQLMYDMAHTYNVALFQGGYLDAPFGDGQIAMFVETIASASYVDSGSRGKHGWAWAPVPMWKVQAPPFAGTDVVMFKGISPEQKAAAWKFMKYLISPEIQAYWSVKTGYMPVTEIALTTPQWKAYEEQNPTVMVPISQIPYGSVDPNVALWDDVRNILGTMVGDVINQKRTVEEGLAWAEQEILLKVAEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P6</accession>
    <name>I2F2P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine/L-proline transport ATP binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730312.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0473"/>
    <dbReference type="EnsemblBacteria" id="AFK06199">
        <property type="protein sequence ID" value="AFK06199"/>
        <property type="gene ID" value="Theba_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0473"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_2_2_0"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="42218" checksum="01D0F25D38A14D21" modified="2012-07-11" version="1">MSIEFKNVVKEYEEGFKAVDNLSITFEDKKLTILIGPSGCGKTTTLKMINRLIEKTDGEIVVDGTSLDEIDPIRLRRSIGYVIQEIGLFPHMTVFDNIAVTPRLMKWDESRIKKHVFELLDLVNLEPSDYAEKYPAQLSGGQRQRVGVARGLASDPKIVLMDEPFGAIDPINREKLQDGFLEIQSKIEKTIIFVTHDIREAIKLGDKIAILDDGKLVQYADTMTVVQEPANEFVEDLLGADRALKGLELVRVRETYVPGGKWIEDTGDCKVKKAKDFLVNEGRKFAYVVDGSKRLKGYVMLKQLSKASDEEPLKKYLRSIETIQPLSNLMEAMSLIMNTGLSSLPVVDDKERLLGILRFKDLVNLVGSYESSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P9</accession>
    <name>I2F2P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Theba_0476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730315.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0476"/>
    <dbReference type="EnsemblBacteria" id="AFK06202">
        <property type="protein sequence ID" value="AFK06202"/>
        <property type="gene ID" value="Theba_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0476"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_0"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="305"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="428"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="528"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="773"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK06202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="880" mass="97386" checksum="5162E47E1E2EA714" modified="2012-07-11" version="1">MSEKFVYYFGKKKAEGDAKMKNLLGGKGANLAEMVKIGIPVPPGFTISAEVCKYYYEHGNKYPESLENEVKEAVRLLEEETGKGFGSNERPLLVSVRSGAAISMPGMMDTILNLGLNDETVDGMIKESGNPRFCYDAYRRFLQMFGDVVLKIEHSEFEGALSSIKKEKGVKLDTELDADDMKEVVKRYLEVYSKAGKEFPQDPWKQLWMATDAVFGSWMNERAIKYRALNGIREGELLGTAVNVVAMVFGNTGEDSGTGVAFTRDPNTGEKQFYGEYLPNAQGEDVVAGTRTPFPLTKLQDINPAVYDQLLDIFSKLENHYRDMQDIEFTVEHGVLYLLQTRNGKRTPYASVKIAVDLADEKRISKEEAVMRVTPEHIETLLHPYFTKETMESAELLAKGIAASPGAASGAVAFDPETAEKMAREEGKAVILVRPETSPEDIAGMAAAQGILTSTGGKTSHAAVVARGMGKTCIVGCEAVEVDQKTRTMRVNGKTINEGEWISIDGTSGEVFMGKLDSVKPQGLEGPLAKLLGWADEIRKLGIRTNADTPRDAKIAREFGAEGIGLTRTEHMFFQEDRIFAVRQMITSSTREQREKALNKLLPMQEEDFYGIFKAMEGLPVTIRLLDPPLHEFLPKEDEDVKELAEEMGMTYEELKTTVEDLHEFNPMMGFRGCRLAVVYPEIAEMQTKAIIGAALKLVEEGKSVVPEIMIPLIVELEELKFVKSVIVKAADELISKSGLKLDYKVGTMIEVPRAALTADEIAKEAEFFSFGTNDLTQMTYGFSRDDYGKFVGHYMEKGILENDPFQKLDRVGVGQLVKMGTEKGRSSRPDLKVGICGEHGGEPSSVEFCHIVGLNYVSCSPYRVPVARLSAAQAVVKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S6</accession>
    <name>I2F2S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PrcB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730336.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0503"/>
    <dbReference type="EnsemblBacteria" id="AFK06229">
        <property type="protein sequence ID" value="AFK06229"/>
        <property type="gene ID" value="Theba_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0503"/>
    <dbReference type="eggNOG" id="ENOG50338HY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115045_0_0_0"/>
    <dbReference type="OrthoDB" id="2003704at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025748">
        <property type="entry name" value="PrcB_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14343">
        <property type="entry name" value="PrcB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PrcB_C" evidence="1">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="268" mass="29792" checksum="F763F54B0D08CC37" modified="2012-07-11" version="1" precursor="true">MKKLIIVFIAIVLLSPFLVAFQVDYTELSSYEPLVLDESTGSRKKSVDFSVLSASDSNKVVIIASGWLFDPESEEQEREASIQLKVNGECYEKIVSLARQGLYFVMKPFLLSFERGYSLSVMELVLDYESVLEDAVKKLEYECLAVEIERSIEAGILIGVVEEKGFRETSVISGEPVLVIQAGEKPTGGYEIEVTSVLLIETRTIKVYATLHSPGSGEFVTQAFTYPRKAIKILGLVPGTYDLIVELEVMKDERVTDTEVFSSSLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S7</accession>
    <name>I2F2S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730337.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0504"/>
    <dbReference type="EnsemblBacteria" id="AFK06230">
        <property type="protein sequence ID" value="AFK06230"/>
        <property type="gene ID" value="Theba_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0504"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026342_2_1_0"/>
    <dbReference type="OrthoDB" id="184000at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="449" mass="51952" checksum="9117C7C1BE109426" modified="2012-07-11" version="1">MRADRAHKLNKSNDRRGNFVLYWMQASQRTEENHALELAKQEAKELDVPLAVLFVLNANYPSGNLRSFSFMFDGLRDVKSELEEQGIRFVIFKGDPVDIVPKVSKRCALVVTDVGYLRHQIDWRKRIAEKLECPFLSVESNVVVPVRTASCKEEYSAATFRKKVMKHFAEFVNDFEAVELRSRASLAEFEGATGIEDVDLSDLDQSVSVVSDFHGGQKEAKRRLEVFLSKNLDRFEEERNDPNSGCLSEMSPFLHFGHISPSYIARRVIDSCSKGKNAYIEELVVRRELGVNFVFYNSKYDSFEALPQWAQKTLNEHRKDKRVRSFSLSELESGKTDDPYWNAAQKEMSLTGKMHGYMRMYWGKKLLEWSSDPESAICSAIYLNDKYELDGRDPNGYAGILWCFGKHDRAWSEREIYGKVRYMNSNGLKRKFDIDSYVKRIDNLSFDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U5</accession>
    <name>I2F2U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730355.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0525"/>
    <dbReference type="EnsemblBacteria" id="AFK06248">
        <property type="protein sequence ID" value="AFK06248"/>
        <property type="gene ID" value="Theba_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0525"/>
    <dbReference type="eggNOG" id="COG1482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020529_0_0_0"/>
    <dbReference type="OrthoDB" id="645703at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="30180" checksum="962D33154A73341B" modified="2012-07-11" version="1" precursor="true">MILRSCPVFSPRPWGDRKLNRIYGVDSEEPIGEVWLLSDIEGMRTWLESGSTRLSPNEVIDKLSGRSLPRFPIMVKHICANEWLSVQVHPDDKFARLYEGEPWGKSECWYFLNEGQVLAGMKNKTKPVDSVREDDLNHILLKRGDLLTLPAGIVHAIGPGSELIEIQQNSDVTYRLYDWDRGRELHIEKASKAVNPSLMPGHYESVKRFDWEYFSVRETSRFSGTGVCVTIEEKPSLYLVIDDVIESAKPFLAITLGEFWSEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W0</accession>
    <name>I2F2W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Capsular exopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730366.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0540"/>
    <dbReference type="EnsemblBacteria" id="AFK06263">
        <property type="protein sequence ID" value="AFK06263"/>
        <property type="gene ID" value="Theba_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0540"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_2_1_0"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="10">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="11">
        <location>
            <begin position="394"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="736" mass="82148" checksum="2DF519A5AD45D68A" modified="2012-07-11" version="1" precursor="true">MSEFEGSDYRELTLEDILRMFKKRMILFVSIVLAVVVVTGIYLIFATPIYEASVTIKVDPTSQSSVSDLFSSSLTGSSGSNISTEVELIKSRTNIEEIIEVLDLVDRIYSEETKNRLLAEGYSQKDLVTSLTRTISSMITVSPVKDTRIVRVSVQNKDPILARDIANTLADVYNTKLAELSKRDLTRKREFIEAQIPLLESDLNEATDRIKDFKEETGIYVLDKHADLLFQMLSSYDKQYNELMISAEEKKAEIETYQSMLDDFDSNDSKSIKALWVQTSESFSVNPVLTSLRQSLATLQVELASLEEQYPKTDPRVRSKITEISKTESLIEEQIQNEFITSGQGMTLNPAYQQIMTGVISSEAGFQILQASIQAVGLLRDQYQSELRSLPAKEQQLLDLERQIAVKESLYTLLLERLEEAKISEAAVVGNAAIVDPATVPQSAVKPNKKLSLAIGGVLGIFLGMLMVFLAEYLDKTLKTEEEIERFSRQPIIGRIPNIEGASEEMYVEKNPTAPSSESIKLAASNLSFTMGEGKSVAVTSVLPTEGKSFVIANLAYSMANSGQKVILLDLDLRRPRVEKILKAEKITKGAVDVIMGNTTIDEVIQHYAVNMDFIAVGTIPPNPTIVLSSKNIDALLSELKQRYDKVLIDMPPAVVTSDVSLIGNKLDGIVLVVRPGRAIKDGLRIVVENLKTVGIKILGVIVNGVDEKNSSYYYHYYYYYNEEGKRQKRRKRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F306</accession>
    <name>I2F306_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492227.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0590"/>
    <dbReference type="EnsemblBacteria" id="AFK06309">
        <property type="protein sequence ID" value="AFK06309"/>
        <property type="gene ID" value="Theba_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0590"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386758_0_0_0"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="714" mass="78465" checksum="21DA6F455BEC5D02" modified="2012-07-11" version="1" precursor="true">MKEQMRKIVFLVIICIAFVAVFSGFGMLKRHNSDFELTESELVTIEYGEIVSLPLSNFVKANGATVEFSLVGENGKIDGDFLVIDSSTLSLPEETIDIIVKSEKSEAVLHITFSVKNLPPPPVLSIANQKVFEGDRLEIDLSELTFSEMNEISYEIVGGPGLIEGDIYRYSSPVREAPVAHRVTIKAIDSLRQWHCETFSIIVIDKNHWPEEPHGPYPGDGIEDFFNDLVLSWECSDPDGDILSYDLYFGTENLGLLAKGINKNTYELPPLEHGETYSWQVVADDGNGGLVKGPVWSFSTEEIPVLTWKRIVGFEGRDSFNTVKSLSSGGYILCGSSDPVSESESLKDSIPRVGWIVKIDNNGFMEWEKRFNLGWVELNDIIATSDDGFLVVGKAIDKTAVGFDADSSLLVIKLDKFANEKWRFKSEGIFNEATSVIEVEDGYLILGTKTESKEDRSILLVKLGKSGSLEWQKSYGGSSFDRGVAFDVDGDGNVVIVAETTSKDGEAKGNPGNRFQVNGIYIELSSVLTIKVNRDGEVIWSKVLGGKSEDSPSSVRINDEGEIIITGSTNSREETFQRDSSDYDGFAAKLSEEGDLLWARVYGGSGNDIIEDFFITQAGGIQAIGFSESNRSINQPVDEAMKRSGITYSDFWVLQTDAEGELLWQKYLGGSKDDVGLSIAYVCDGFVVAGYSASIDGDVGSNKGDFDAAVFYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F328</accession>
    <name>I2F328_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Parvulin-like peptidyl-prolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730409.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0612"/>
    <dbReference type="EnsemblBacteria" id="AFK06331">
        <property type="protein sequence ID" value="AFK06331"/>
        <property type="gene ID" value="Theba_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0612"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030639_0_0_0"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="182"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="546" mass="61451" checksum="D577B2A42A03D586" modified="2012-07-11" version="1" precursor="true">MKKFLLILLAAFFSLTLIGAEYAVRITKGGEAVSNEFWITREEIEQAFSATVANAASQGIILDPYFDSYFTPSELGLKTMIIPYIVDEKLIDYFAWESNLIPSEEEIDAETDSMMEMYTSSPDMVEQIEAIYGSMDAFRSEIRNYVSDALKAELVQESVAPLNDDALAAYFEEFKTEIKNQFETIRARHILVTEEATATELMDRINSGEITFAEAALQFSIDSSTAANGGELGSIVRGQTVPEFEEAILAAPIGELYGPVQSEFGYHLIIVEERNEINSLEDVVNSASYNDFVSGYQNDTYNRWIESYIEENEFDYEILDNELLFYNEYAKAKATEETANEFFVEIASGIFGDGTSSEASLMEYAAFIELSEMLGFTDSPDYETAIRNLFEAGEKRGMIVQKMYDLDSENPEVAAAYYNALLEELENTFMNQDLLQQQLSSYGQSFVDYVFNTIGEIESGLTSVLEKEISDGLRADVLYILIRNNSLSLELDYSPDWRKEKLNQRLGYLEALIQVEPSEAAQTEIESIISELEQIEAEAETPAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F350</accession>
    <name>I2F350_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730430.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0635"/>
    <dbReference type="EnsemblBacteria" id="AFK06353">
        <property type="protein sequence ID" value="AFK06353"/>
        <property type="gene ID" value="Theba_0635"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0635"/>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084406_0_0_0"/>
    <dbReference type="OrthoDB" id="1656873at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="24527" checksum="27EAB5922301FA46" modified="2012-07-11" version="1" precursor="true">MFWDPTFIILIPAIILAAYAQFLVSSRFAHYSKVKSTFGLNGTQLARQLLDNAGLYDIKIERIRGNLTDHYDPKNRIVRLSDTTHNSSSIAALGVVAHEIGHAIQDKEKYVPLIVRNAVVPVAQIGSSLSWIIFIIGLLMVSPVLIRIGILVFSAFVFFTLVTLPVEFNASSRAKKLLSSMGMPSKELEGVSSVLGAAAMTYVASAATAILQLFRMLFLSGAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F373</accession>
    <name>I2F373_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Theba_0659</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730451.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0659"/>
    <dbReference type="EnsemblBacteria" id="AFK06376">
        <property type="protein sequence ID" value="AFK06376"/>
        <property type="gene ID" value="Theba_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0659"/>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_0_0"/>
    <dbReference type="OrthoDB" id="1064872at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="193"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="13">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK06376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="38708" checksum="572F7DBC3EED6A56" modified="2012-07-11" version="1">MPELRKDPIIKRWVIIATERARRPHDFINAKENVESAFCPFDYGNEHTTPPEIMAFRPADTAKDSPGWWVRVVQNKFPALDSNIEPERFGHGMYDVIKGFGTHEVIIETPDHNASMATLSYGQVREVVWAYKERLQTLEKDSRIKYILIFKNHGREAGASLVHSHSQLIATPIVPKRVAEEIAGAAEYYRFRERCVYCDMVNQETLEGTRVVEENSDFVAFEPFAARFPFETWIVPKVHSHNFGEISATQIESFSIILKNTLLRIYKALDNPPYNFMLHTGIRGIDESNHYHWHLEIVPRLTRVAGFEWGSGFYINPMPPEHAAMYLREVSTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F376</accession>
    <name>I2F376_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730454.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0662"/>
    <dbReference type="EnsemblBacteria" id="AFK06379">
        <property type="protein sequence ID" value="AFK06379"/>
        <property type="gene ID" value="Theba_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0662"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_0"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="9">
        <location>
            <begin position="44"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="10">
        <location>
            <begin position="200"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="11">
        <location>
            <begin position="312"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="8">
        <location>
            <begin position="503"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="549" mass="61453" checksum="D767B29434B80A16" modified="2012-07-11" version="1">MLRGERAVNQEYKRWLDNASDEIRDELKDLTPEEVRERFSLDLEFGTGGMRGVMGAGTNRINSYTIKRASLGFGRWISENYSDPSVVIAFDTRHKSAQFAQTTAEVLSSMGIRVHVFIEPMPVPILSYAVRELKASGGVVITASHNPPQYNGYKVYTSDGTQAVPSYAEEIIKRVEASDYFEDISPRSELINSIPNSLLEKYIDTVKENILGLTSDYEELNVVYTPLHGSGNFPVYKALTVLGHRVKRVEEQAIPDGDFPTVQSPNPEDPRAFSMALDVAREIGADLVIATDPDCDRLGIMVAHNGDYAPLNGNQTGAIMTSFILERMEDSLPSDPFIVKTIVSTDLVKRIASKYGVEVKETLTGFKFIGEIIEKAEMDGKGNYLFGFEESYGSLFGKHARDKDAVSAAALACAIGGHLKRKEMTLIDYLEEIYSEFGYFQEALVNKEYEGIQGKEKIELIMTELRHIEPSKLKDMAIRGMKDYLNGYGNLPPSDVISMEMENDCKIIVRPSGTEPKIKFYLMARGENREEAEKKIEEMKELVERIACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F385</accession>
    <name>I2F385_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta subunit</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730461.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0671"/>
    <dbReference type="EnsemblBacteria" id="AFK06388">
        <property type="protein sequence ID" value="AFK06388"/>
        <property type="gene ID" value="Theba_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0671"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888159_0_0_0"/>
    <dbReference type="OrthoDB" id="1453267at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="313" mass="36080" checksum="669B1CEBB233A094" modified="2012-07-11" version="1">MIYEMLGDSEVLKDFFILERGEGYLTISEDMPDKVNRFKMAVSTSGMFGRKPVRLSGFDSWKKEEKTQIEKLLPLFQDEIDVFLDGKVSPKVKSEKSIFDLPKPWEEEKWNDHIITISERAGMKISRAAAESLFRKVGRREYRILRELEKLSVFSNEIDQLMVERLIDFDKEVEVESLAFDFLNHKEDFLSSSRKCMIPFAYFASVLLNIIIDLGTIIDTKKGKMNISWSEIRKLSNTTSIGTARIARLVGYSFSSTKEQRNDLTRLYSAESLKGLIVLLQEIDESIKNGKIDSEIAFFKLHEESLKLQVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F388</accession>
    <name>I2F388_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ORF">Theba_0674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0674"/>
    <dbReference type="EnsemblBacteria" id="AFK06391">
        <property type="protein sequence ID" value="AFK06391"/>
        <property type="gene ID" value="Theba_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0674"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="690" mass="76526" checksum="D6678472AAFC1A36" modified="2012-07-11" version="1">MKERATTLEKTRNIGIMAHIDAGKTTTTERILFYTGKNYKLGSVDEGTATMDWMDQEKERGITITSAATTAFWKDHRINIIDTPGHVDFTVEVERSLRVLDGAVAVFDAQAGVEPQSETVWRQADKYHVPRIAFMNKMDKIGADFLAAIGTMVTKLKANPVAIQLPIGSESGFEGIIDLVQMKALRWTNQEGTEFTYSNIPEFLQAQVEEAREDLVTHVAEFDEELMDLYIEGEELPVDRLKAAIRKATLLGQITPVLCGSAFRNKGIQPLLDAIVDYLPSPKDLPPVVGEIIDSERKIEVYPDENGPFVAMAFKIMIDPFVGKLTFLRVYSGSLEKGAYVINTNKNLKERISRLLFMHADKREEVDYIRAGDIVAVVGLKNTMTGETIALSEEKIVLEKIEFPEPVISIAIEPQTKDDASKLTKALLALVEEDPSLKSYVDGETGETILSGMGELHLEVIVERIKREFNVGLRVGNPQVAYRETIRSKAIGESKYVRQTGGKGQYGHVILSVEPITDKSANFVFEDKTVGGTIPREFIKPIERGVREAMDSGYLAGYPMVNVKVSLLDGSYHEVDSSEIAFSIAGSMAFKEAARKASPALLEPIMAVEINTPEEYMGDLIADLNSRRAKIEGFETRAGLKIIKAHVPLSELFGYATVCRSLSQGRAIHVIQFSHYSEVPERIAEKILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F394</accession>
    <name>I2F394_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="7" type="ORF">Theba_0680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730464.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0680"/>
    <dbReference type="EnsemblBacteria" id="AFK06397">
        <property type="protein sequence ID" value="AFK06397"/>
        <property type="gene ID" value="Theba_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0680"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_0"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="30753" checksum="C1113AEE15640AF1" modified="2012-07-11" version="1">MALRKFNPVTKSRRFMLLPDFKEVTKSEPEKSLLEPIKKNAGRNHHGRITVRHQGGGTKRRYRIIDFKREKMGIPAKVISIEYDPNRTARIALLQYVDGEKRYMLAPKGLKVGDSVQNGDMAEISVGNSMSLERIPVGTIVHNIEFLPGKGGQIARAAGTYAQLMAKEGRYALLRMPSGELRRVVVKCMATIGMVGNEEHSNEIHGKAGRKRWLGVRPSVRGMTMNPVDHPMGGGEGRSKGHLPQSPWGQPARGYKTRKNKKPSDSLIVKRRNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A8</accession>
    <name>I2F3A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">Theba_0694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0694"/>
    <dbReference type="EnsemblBacteria" id="AFK06411">
        <property type="protein sequence ID" value="AFK06411"/>
        <property type="gene ID" value="Theba_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0694"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="201" mass="21758" checksum="8EE10E02A8CB45C9" modified="2012-07-11" version="1">MAEEMKNDRNSKSSREGRRNPRASRNAPVEKQVEDNEFEERIIEIRRVTKVVAGGKNLSFRVVAVVGNRDGKVGLGIGSAREVPTAIRKAVLEAKKNVTEVAVRNETVPHETVGRQDSARIMLKPAGPGTGIIANSPVRAVVELAGVKNILTKSLGSSNTLNMARAALNGLLSLRSPQDFAKLRDIPLKTVFHGFSEEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B2</accession>
    <name>I2F3B2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ORF">Theba_0698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730476.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0698"/>
    <dbReference type="EnsemblBacteria" id="AFK06415">
        <property type="protein sequence ID" value="AFK06415"/>
        <property type="gene ID" value="Theba_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0698"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_0"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="219" mass="24487" checksum="F80E2029C17A9BCD" modified="2012-07-11" version="1">MNVILMGPPGAGKGTQAKRIAQIFKIPHISTGDMLREAVAAGTDLGLKVKEIMDKGLLVPDDLMIDLVRERLSREDTRNGFILDGFPRTVEQAAALDEMLEDLGRKIDVALLVNADEEEVVKRISSRRVCPECGKVYNLLTIRPKVEGRCDNDGAELIQRDDDMPETVRARYRVYLEKTEPVIQYYSSNKSQFLEVDGTGEIDVVTDKIVEHLESTRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F8</accession>
    <name>I2F3F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HHH_8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730515.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0746"/>
    <dbReference type="EnsemblBacteria" id="AFK06461">
        <property type="protein sequence ID" value="AFK06461"/>
        <property type="gene ID" value="Theba_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0746"/>
    <dbReference type="eggNOG" id="COG1796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1710870_0_0_0"/>
    <dbReference type="OrthoDB" id="2060981at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_8" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="154" mass="17511" checksum="842ECDFFF766CC4D" modified="2012-07-11" version="1">MEKEDLARQFDLLSRLLRVTRDNPFKIRTYEFAAKTIRSNLASGELSSEDIVALSSIKGIGKAVVEKSLEFLHRSEIQKITDLKSKIPNSIYMLTAQDLVDPEVLSYIWKDMGLTKPLEILEFLLDKRESLKLSQERLSNIEALLIEAGSSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G2</accession>
    <name>I2F3G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0750"/>
    <dbReference type="EnsemblBacteria" id="AFK06465">
        <property type="protein sequence ID" value="AFK06465"/>
        <property type="gene ID" value="Theba_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0750"/>
    <dbReference type="HOGENOM" id="CLU_2666860_0_0_0"/>
    <dbReference type="OrthoDB" id="2055291at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035205">
        <property type="entry name" value="DUF5320"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17253">
        <property type="entry name" value="DUF5320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="75" mass="8551" checksum="6C4C0D4A94CF95E4" modified="2012-07-11" version="1">MPWRDGTGPEGYGPMTGWGMGNCAPRDRVAGPANPVRNYSYRFFPRRRLFLGRRMGFGAGYGPGRGMGYGFRRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J9</accession>
    <name>I2F3J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zc3h12a-like Ribonuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730555.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0788"/>
    <dbReference type="EnsemblBacteria" id="AFK06502">
        <property type="protein sequence ID" value="AFK06502"/>
        <property type="gene ID" value="Theba_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0788"/>
    <dbReference type="eggNOG" id="ENOG50335JR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831077_0_0_0"/>
    <dbReference type="OrthoDB" id="1724787at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="334" mass="38246" checksum="6F3E79915EBB2FE7" modified="2012-07-11" version="1">MMTDDILNFVKEAASSQGFYAFYSNRKERVESLNRALKRSPVSSTTIAKIQRRISGLAHLSYEEIEFSIDILRERDRAPEDRVEYASTLSKASVSDMGHLLFFVDPRNNPPVTGPVKERIQSIDDYKEWQSLTRSVGEHGIQDFVMLEAALLFEREENNRSSNLSERLIRAVYTDISEIKTLRNAVASLSKSEKRLLSNLRFTHPYVKTAIMSNHSRPVVIDGSNVVFSMTDHADLKRIDDLFLRMALCRIALFPYRIVFDANIRYTIGGFQQESLNRLLSLPQVETYSPADDRLIFLAREGGSAVITYDRFLDHAAEDITIIRPEEIDESLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L4</accession>
    <name>I2F3L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730569.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0803"/>
    <dbReference type="EnsemblBacteria" id="AFK06517">
        <property type="protein sequence ID" value="AFK06517"/>
        <property type="gene ID" value="Theba_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0803"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103695_0_0_0"/>
    <dbReference type="OrthoDB" id="1617484at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="205" mass="23039" checksum="D2B7DC6E18ECEDED" modified="2012-07-11" version="1">MEREELINRIVEEKGVEAAPVLLSLLVSEDSETAQICFDALIQMGKDVVPFLIEKMRSEDIDPVSRLYLADLAGEIGDIRAVTHLYELLSKYSDERSQIVIYEALARLGEGEKVVDVLALMLEENYDAELQDQLIMALSNTDSSVAVKALAGFYGNKLADKSAKAFALEGIHSILARRHELKNYLLSLHNGKEIAERLYQWQKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M5</accession>
    <name>I2F3M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">Theba_0814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0814"/>
    <dbReference type="EnsemblBacteria" id="AFK06528">
        <property type="protein sequence ID" value="AFK06528"/>
        <property type="gene ID" value="Theba_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0814"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="284" mass="31367" checksum="173170EB0494CF3B" modified="2012-07-11" version="1">MLIRLGAHMSISKGFDKVPGDTVGIGGNTFQIFPHSPRMWKASLPKSEMSASFISEMKDKALDPFDCMVHSGYLVNIASPNDEVWEKSVNLLSLEMKITATLGLKYLNFHPGSHLGEGLSEGLERILKGVEIVLGENRDNDVMLLLENVSAKGNHIGSSFEELAAIIDGSIQPERIGITYDTCHGFDSGFDIRDLEGTLKLIDKIDSTVGYEKLKMIHLNDSKYPLGAGKDRHEMIGKGYIGMNGGFKEFLSNEKIQEIPWLLETPGDDADHALEIKYVRELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N8</accession>
    <name>I2F3N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730584.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0827"/>
    <dbReference type="EnsemblBacteria" id="AFK06541">
        <property type="protein sequence ID" value="AFK06541"/>
        <property type="gene ID" value="Theba_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0827"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="379" mass="42249" checksum="F8F3BB0E0B0E636C" modified="2012-07-11" version="1">MAEVILEKVGKTYPNGVKAVLDANLEVKDKEFLVLLGPSGCGKTTTLRMIAGLEEITEGTIKIGGKVVNDVEPKDRDIAMVFQNYALYPHMSVYENMAFGLKLRKTPKPEIEERVREAARILGIEQLLDRKPKQLSGGQRQRVAVGRAIVRKPKVFLFDEPLSNLDAKLRVQMRAELKRLHQNLQATIIYVTHDQVEAMTMADKIVIMKDGIIQQIGDPYSVYFEPRNKFVAGFIGTPAMNFISAKLVSENGSVWVVKEDMKLLVPEDKVDKVKGLVGKDITFGIRPEDIYDKMYAVAPKDEYTVKGSVDVVEPLGSETLIHANIHGDDIVAKVDPKSRAVAGDKMDLVFDMSMMHLFDPETEENVLAGTHQDATPENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P1</accession>
    <name>I2F3P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730586.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0830"/>
    <dbReference type="EnsemblBacteria" id="AFK06544">
        <property type="protein sequence ID" value="AFK06544"/>
        <property type="gene ID" value="Theba_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0830"/>
    <dbReference type="eggNOG" id="COG2869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077882_0_2_0"/>
    <dbReference type="OrthoDB" id="730368at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010204">
        <property type="entry name" value="NqrC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37838">
        <property type="entry name" value="PTHR37838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FMN_bind" evidence="11">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="206" mass="22454" checksum="418931AE487F3F58" modified="2012-07-11" version="1" precursor="true">MSGRLYSVVFTFVLTTIFVLCLAGINALASGTIEKNEQLEFQRSLVYVFNLAEDIDSVSDEEILGLYGNRIEEITGDQTVYIVNKDGSKELAFTVQSPGLWGTITALIAFNEEGTRITGIDFVSHSETPGLGGRIDESRFKEQFRGEQISSDPSARVAVVTGQDTVSKEDARVDAITGATRTSESIQILLNKAINSVLPVVREVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X2</accession>
    <name>I2F3X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730648.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0918"/>
    <dbReference type="EnsemblBacteria" id="AFK06625">
        <property type="protein sequence ID" value="AFK06625"/>
        <property type="gene ID" value="Theba_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0918"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133275_0_0_0"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="145" mass="16610" checksum="6E273D0A201371C6" modified="2012-07-11" version="1">MIKEVEFDNLPGRFIEIFSGCLGRPEQSDEVLKMYQAPERRLFVMRQGGSIVAVAGLKLHELEEPELLHLAVRKDKRRSGFGSTLIKTMINSFMIDTLAVWTDEDAVGFYEKIGFIVVNEVQTQNGLVRYKLRFSRAKSRGRLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F408</accession>
    <name>I2F408_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein implicated in regulation of membrane protease activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730682.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0955"/>
    <dbReference type="EnsemblBacteria" id="AFK06661">
        <property type="protein sequence ID" value="AFK06661"/>
        <property type="gene ID" value="Theba_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0955"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116732_4_2_0"/>
    <dbReference type="OrthoDB" id="1951939at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="16315" checksum="DFECD61A7139F237" modified="2012-07-11" version="1">MGYIGWMIFGVVLLVAEILTPTFFFLWFSIGSFLAGLTAMFSFSLGWQVLVFALSSTLLVLLTRPIARKLSKGDSPKKMYIDGLVGSRGRVTVEINPQLEKGLVRIEGEDWRAASLNGETIPVDSLVRVTRLEGTLIYVERIADESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F444</accession>
    <name>I2F444_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730712.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0991"/>
    <dbReference type="EnsemblBacteria" id="AFK06697">
        <property type="protein sequence ID" value="AFK06697"/>
        <property type="gene ID" value="Theba_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0991"/>
    <dbReference type="eggNOG" id="COG2096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_1_0"/>
    <dbReference type="OrthoDB" id="1401910at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="176" mass="19868" checksum="7A5BF26EA47710F4" modified="2012-07-11" version="1">MSITTGTGDKGETSLWSGERVNKDSLRVEAYGTVDELSSFLGEAKHFVSEEIGRHIVSIQRFLFKLAGQLASRDMQYVEPIVENDIVAITELVHEFESVVKLDGFVIPGSTIGSSKIDICRTVARRAERRIVALSRVETIDTTLLKYINRLSDLLFIFARYEEYKAGKIVYKKDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F485</accession>
    <name>I2F485_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730746.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1033"/>
    <dbReference type="EnsemblBacteria" id="AFK06738">
        <property type="protein sequence ID" value="AFK06738"/>
        <property type="gene ID" value="Theba_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1033"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_0"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="35"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="205" mass="22685" checksum="4A27752612CC1E0D" modified="2012-07-11" version="1">MTDYVKRKELLLELNSKISDCSLCPLSSSRTNTVPGEGSIETPVVFVGEGPGADEDASGRPFVGRAGELLTKILESVKLSREDIFITNIVKCRPPKNRVPTAEEQKACSPYMLSQLAIIRPKLIVALGATALSYFVNEEGIQITKVRGRIFDWIGGIKVFAMFHPSYLLRNASRAPGSPKSLTWEDIQNVRKMYDQLLSGRNIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H6</accession>
    <name>I2F4H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06829">
        <property type="protein sequence ID" value="AFK06829"/>
        <property type="gene ID" value="Theba_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1125"/>
    <dbReference type="HOGENOM" id="CLU_2523675_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="84" mass="9643" checksum="1E292A7C74588488" modified="2012-07-11" version="1">MSILTTAQFSDFQSLEKGFPIHGKTLLNSEVCFIRAGIDQFIQRFVFFHISSSLCITLENVRCINLYCSTTHARGGIWIERQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I1</accession>
    <name>I2F4I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486337.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1130"/>
    <dbReference type="EnsemblBacteria" id="AFK06834">
        <property type="protein sequence ID" value="AFK06834"/>
        <property type="gene ID" value="Theba_1130"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1130"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="117" mass="13208" checksum="17246532CCF38698" modified="2012-07-11" version="1">MAKKMPVVYWEINAVDGESLSEFYEEVFEWETEVSDTGFHSFKSGDPKGINGGIFTGKGVLPTHRALYIEVEDMNEIIKRVQDHGQEILQGPFKSGNTILAFFTDPEGHMIGLIQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I2</accession>
    <name>I2F4I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486339.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06835">
        <property type="protein sequence ID" value="AFK06835"/>
        <property type="gene ID" value="Theba_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1131"/>
    <dbReference type="HOGENOM" id="CLU_2423518_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="91" mass="9495" checksum="AADC63865128BADC" modified="2012-07-11" version="1" precursor="true">MKKIVLITITVLLIGGMTLAVGYGTKAMQRVQDPTTCENFVDADGDGINDNCPNDGVRELKNAQDGTGYRHGASGEKGPGLGRGFGKAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I6</accession>
    <name>I2F4I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730830.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06839">
        <property type="protein sequence ID" value="AFK06839"/>
        <property type="gene ID" value="Theba_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1135"/>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058017_0_0_0"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="44357" checksum="9EB4EF07ED967A68" modified="2012-07-11" version="1">MDSDELVQSLEEVQKRKEMELPSRLRPYFDKIDMKNRAVLVFGPRGVGKTTFLLNRFRERKVLYVSADNPLVSTSDIWSIAKTAFVRGYEGIVVDEAHYAKDWSIHLKALYDSYPGKLVIASDSSSLVLRQGIADLSRRFSRVQIPLMSLREYIFLRDGTLLPQLEPFSPEPSAVKEIMNGTNVLSAFEEYLERGFRPSYMEWDFREQIEHIIEKTLHGDVPFFVPQISDIHFRLMNAVVGFLATSKVLTLNIERMCRDWGIGKRKLYELLTVMNATGVIRIVYRENDNRTFSKGEKIFFGDPAFYSIGTGNIGTRREAFVAQSFEDAGRKVFACADERNGDFSVDGKIIEVGGRSKKPKKAEFVIRDDTDLPYSNSIPMWTLGFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J3</accession>
    <name>I2F4J3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730837.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06846">
        <property type="protein sequence ID" value="AFK06846"/>
        <property type="gene ID" value="Theba_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1144"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181375_0_0_0"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10564" checksum="1EE1F0C22B09160B" modified="2012-07-11" version="1">MKYIATRDLRSNPSAVWETLDEGSEVIVTVNGKPKAIMIRADEDLDFLMKAISRAKAELAVERMRLQSLKLGLNSLSAEEIDREITESRQEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M8</accession>
    <name>I2F4M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PLP-dependent enzyme possibly involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730870.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1183"/>
    <dbReference type="EnsemblBacteria" id="AFK06881">
        <property type="protein sequence ID" value="AFK06881"/>
        <property type="gene ID" value="Theba_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1183"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_0"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="426" mass="47488" checksum="E66915EDC9C5BADB" modified="2012-07-11" version="1">MHIPLFDLTRQYSDLREEILGKIDEALLGGRVILGEAVRELEQSVADLIGVKHAIGVANGSDALLIAVAALGIGPGDYVITTPYTFFATVSSITRNGATPLFADIDPITYNIDLDKVEELLQIHPERERIKAIIPVHLFGQSMELGRLENIREIYGVKIIEDCAQSIGASWSYPDGSTVMTGSIGDLSTFSFFPTKNLGAYGDGGMITTDDDELAAFCRSFRVHGSPVKYIHDMIGINSRLDELQAIVLNTKLKHLQEYERRRIEIAMKYQAEMTKNGLNVVGCGLWVVGKDQSLSHNAQPTTYNDVVIHYPSVPYSVNGEPRTANDYCFSHVFHQYVVRFEGFSREQRDSLRDYLAEQGIGTSIYYPMGLHQQKCFAYLGVPTGALPETERACEETLALPIFPEMTDEEIKYVVDKIAEFVTNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N4</accession>
    <name>I2F4N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730875.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06887">
        <property type="protein sequence ID" value="AFK06887"/>
        <property type="gene ID" value="Theba_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1189"/>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058622_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="36665" checksum="651A8468AFB4E504" modified="2012-07-11" version="1">MRYDKQTIGQLASELGFVRDTYEKTLRLVEVLQFIESDTLLLEALALKGGTAINLMIIQLPRLSVDIDLDYCRSISREIMIEDRTVITDKITLFMDANGYRHSDKSKRHYSLESHVFEYTNSGGAKDNIKIEINFSMRAHVLPLEVRRTAIPGIIQEIRSRCVSSIEILSSKIVALLTRGATRDLYDVNKMISLLSLNEREIELLRKCTLFYFSIGSTGIPESFDFDRLKSITKYRIRTELLPVLRKEEKIDLDEMLSMVEKFLSKLLVFTTKERNFIDRFRKHDYHPELLFDDQQIAERIRFHPMALWKTNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W5</accession>
    <name>I2F4W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1280"/>
    <dbReference type="EnsemblBacteria" id="AFK06968">
        <property type="protein sequence ID" value="AFK06968"/>
        <property type="gene ID" value="Theba_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1280"/>
    <dbReference type="HOGENOM" id="CLU_1271056_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="217" mass="24018" checksum="F5C3A63BC71AC3E9" modified="2012-07-11" version="1">MTGKRFSSAYSGFLLLSEHGSQDQDGKTSSGRRFRNQQTLSHPSRLLGCLSHCHPELVSGSVFPSSKDPLGGRWNFDWQTVFISAQRVLAPKRTTALKTKMVKQVQADVFGISKHCRTRLAFSNVLNLVIPNLFRDLCLHLRRILSEYGGPLTVDPKLFLRNSLTSGDVLRRITSALASLLISEAGGPLTDKAIYSQIFEDLPGSLSPSYDKIRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z3</accession>
    <name>I2F4Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730968.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1308"/>
    <dbReference type="EnsemblBacteria" id="AFK06996">
        <property type="protein sequence ID" value="AFK06996"/>
        <property type="gene ID" value="Theba_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1308"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183917_0_0_0"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TM1586_NiRdase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="234" mass="26674" checksum="C4A08DF634919DDE" modified="2012-07-11" version="1">MLSKQEIKKAIGLRVTQRKFQERQLSPEQKKEVNDALRDIVPINSESVLHWYFSPEFPSGSGIVLAKMSDFSTPSLVKYGFEGEQIVLNLTLKGFSTSWARLPNYLSMIVVGFAADGSGDIVERASRFLYREANRKPLKEVVYGKEDYIDEKMKDIIDAGRMAPSSFNRQPWKFEVLGENEIAIHGWKKIPLIYEEVIAIDLGVVLSHMYLMANAMSDRARVEAISQRSYLLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F508</accession>
    <name>I2F508_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA synthetase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730979.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1323"/>
    <dbReference type="EnsemblBacteria" id="AFK07011">
        <property type="protein sequence ID" value="AFK07011"/>
        <property type="gene ID" value="Theba_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1323"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026233_1_0_0"/>
    <dbReference type="OrthoDB" id="749518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="2">
        <location>
            <begin position="190"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="1">
        <location>
            <begin position="347"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="510" mass="55452" checksum="2EEE85353DE289B0" modified="2012-07-11" version="1">MKKIEVVRGEYYDSVTLMLVAKEIKRINGVVDAVLNMATEANIDIMKAAGFEIKAGFLSPDDLLIGIDYRKDEIDRIFETARSYLASPPWKKKEDDTEYTPGTLEGALAVLRDANLALISLPGRFAAAEAMKALKNGLNVMLYSDNVATEDEIKLKHYADRNDLIVMGPDCGTAVINGKGLGFSNVCPEGPVGIVAASGTGLQEVMVQLSRRGIGVKHGIGTGGRDVKECVGGISFLKGIRELSDDPEISLIIAVGKPPDPEVKERILNSLKKTGKDCVICFMGDDCGKDEDRVHYSAELEECAVVAEAILNGKEVSAARDKLRAEYASLSGWRPIEEVQGKYVRGLFTGGTLCYEAQYIAQSYINPIYSNAPLRKEFKLENSLKPIGHSFIDYGEDEFTQGRLHPMIDPSFRAEQLKEQSEDNSVAVVLFDVVLGYGSAENPSQEVAEAIGAVKREIKPVYVAYVCGTAGDPQDLAKQISLLEDAGVIVCESNARAALLASSLISRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F509</accession>
    <name>I2F509_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486723.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1324"/>
    <dbReference type="EnsemblBacteria" id="AFK07012">
        <property type="protein sequence ID" value="AFK07012"/>
        <property type="gene ID" value="Theba_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1324"/>
    <dbReference type="eggNOG" id="ENOG503363M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101402_0_0_0"/>
    <dbReference type="OrthoDB" id="2022437at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="235" mass="26432" checksum="B860B3A5103DAF91" modified="2012-07-11" version="1">MIYLYPYERSSDWQESTYRLTVKTAFSKSVNFRDEQGRRYSLLVDDDDFLPRSALIEGLPPMASGHEVGIDIKGAVVKFDPSAMSGLPDRKMRGLWLEWLSLMDNAELKCIQENLDEPFRLVGLGPGLTPAGDDFLVGWITACKLEGRNTKKLSSEIEEALSRKTTWFSSEMIRDALDGKFWKRGIELALALNEGDSFQVMKRAGKIINWGHSSGKAWLAGFAYGIERGSDPQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F518</accession>
    <name>I2F518_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730983.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07021">
        <property type="protein sequence ID" value="AFK07021"/>
        <property type="gene ID" value="Theba_1333"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_3_1_0"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
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        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
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        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSKETOLASE_1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="632" mass="68842" checksum="D281EF48750CD892" modified="2012-07-11" version="1">MAGLRTREELKRLEDLGRICRGDIIKMTTVANSGHPGGSMSSIDIFLSIYDFAKNDPNKPFDPERDRVIVSHGHTSPGVYSTLGRLGFVDIDEVIAGFRHPGSIFEGHITRGIPGVEWTTGNLGQGLSVGVGMALASKLSGKNNRVFVAMSDAEQAKGQVGEARRTAVKYGLDNLVVVIDYNDAQISGRAHNIMYVDIKANYLADGWKVIEVDGHDYLELNEALVEAEDSKGPVVVIGKTIMGKGVSFMEGDVSYHGKPLDFEKAALALAELGLENDIDRFVQMRKVLPSYHEQVQAIDEDVKPFTGDPIVYPVEKKTDNRSAFGKAVGDIGRLNKGRLPVMVVDCDLKPSTKVSEFEKVWPENFVQIGVQEHNAATLAGAASVCGVLTFFADFGVFGVDETYNQQRLNDINKANVKVGVTHVGIDVGEDGKTHHCLDYIGALRNFYGFKLIVPADPNQTDKAVRFMSETKGNFVIAMGRSTMNPVADENGNPFFGEEYKFEYGKVDVIRKGKDITLVTTGQVTHHAVKAADELRSHGIEVAVLNVSCPLGANFDSVKEFFSSIVISLEDHNVASGLGSILADYLVGSGIIPKSFEKIGVERYMFSGDNELLYDLAGLSSKAIVERIRGIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F520</accession>
    <name>I2F520_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730984.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1335"/>
    <dbReference type="EnsemblBacteria" id="AFK07023">
        <property type="protein sequence ID" value="AFK07023"/>
        <property type="gene ID" value="Theba_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1335"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="342" mass="38931" checksum="E83DDEDC43060689" modified="2012-07-11" version="1">MQWFDGVVNDRLSRLLARSSGISITLVGRDSEYLKVLATSIVEGDPKWSKRRYVEDFLLIEPESGNIGIDRIRDIEEIMLHRPSGDGKKYVLIHQCERMTDESANAFLKILEEPPSFATLIMTTTSWQSLLPTIRSRTVSMRGEVPRELMDELRAKYGKRVPEIFAASRENFTILRHFLEQNPDSVESASFEVPSDLDGLVELIKEDVSESFESIVRKRRAFVALSRNFISTDSFFSTFRRVSSVFTGSGSFERARELVKVVRSILSDAVIASVNPSSKSLTNLDLIEWLVDYDLGKEIMTDFIWCDRFLRQRTSSLSSTLVALRALNSLSRNLLRRENGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F533</accession>
    <name>I2F533_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transport complex, RnfABCDGE type, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730986.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1348"/>
    <dbReference type="EnsemblBacteria" id="AFK07036">
        <property type="protein sequence ID" value="AFK07036"/>
        <property type="gene ID" value="Theba_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1348"/>
    <dbReference type="eggNOG" id="COG2878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1203690_0_0_0"/>
    <dbReference type="OrthoDB" id="1969005at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="6">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="6">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="230" mass="24247" checksum="2D8809D06BC7297A" modified="2012-07-11" version="1" precursor="true">MTIVYSVLFMSVLGVGAGIFLAFASAKFAVKKDPRIALIEASLPGANCGACGFPGCAAFAKAVAEGKAPIEGCIPGKRSGVPEKLKLILDTDIDKLIALFDENEEDAEKTLEKLLASSGKAVKAAPPKIQRPTQEEIDSYKEKLKENPRAAVIFAVLPNINCALCGSPGCAAFAIKVANKDEDIAKCVPGKPQNVSQKVAKIMALSEAELQKIIEETSGEPAEIKKKFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F572</accession>
    <name>I2F572_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731021.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1387"/>
    <dbReference type="EnsemblBacteria" id="AFK07075">
        <property type="protein sequence ID" value="AFK07075"/>
        <property type="gene ID" value="Theba_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1387"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391715_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657615" evidence="3">
        <location>
            <begin position="19"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="504"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="704" mass="77938" checksum="A4128442DAF41AE8" modified="2012-07-11" version="1" precursor="true">MKKIILMTVVVISCITFAQQFDELFNNLLLKSEDFVSFSGAGFDARFVPTYAATDSEIRFSDGQNLLGILVVRSTRVMDIEINNVVIINSEDDSRVAFKIYKVEDLTSPVELPFSLPSGGVLVLTSETPLQDYFMDIRIQQILLPWRVKTSEPDKVVEMAPVTLEETASEVDVEGNDNYDSLTVSISDLNDRLDFLQDNVEGLNLQFRRLNTLFLDTQVALAEYKAAVDEGAFDTEEFAMTIENRLTALEETVVDNPITRIEFEELSESLDRLYSSLAEWSDEISKIETLEASQTGLQLSIENLENTVKSLREIIPQQSDSEDIVSINDKIGEITTSLSAAENELQEMKSFIGLQSEEISTVRNELGDALDSLTARLNFVELSAKTSSESIGTNNELLAEITAEVDALSDYVSEQALSQMEKFRSLSEAFSDIEKRVIAAETSLSDFEEIKARLSASESATRILSDRISSLEVFYSSAEDIIPILEEKVGNLETSVFGTGKINMDELETEILQLREIADSLSRGFVKFNSELITLRESIPPEGVSIETFENSINELSDAIININADLSEIRSSVAELELSLGVLEDSLVGVSVGLDSMKGNFDGSVAAIDSNLKAIQKIEDDLLLTQEDLAKTRDQLSTLTKELEKTLVTREEIITITEEAVKQSREATAQEISSLRRTNNIWLTVAVISSLAAIVLGVVNILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B6</accession>
    <name>I2F5B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731063.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1433"/>
    <dbReference type="EnsemblBacteria" id="AFK07119">
        <property type="protein sequence ID" value="AFK07119"/>
        <property type="gene ID" value="Theba_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1433"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_0_0"/>
    <dbReference type="OrthoDB" id="299689at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="533"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1038" mass="119036" checksum="18C15F772AC0BD64" modified="2012-07-11" version="1">MYHSRNEYCTRLRKELAELFPYTLIERKAIGGWRFSDFGAERPPEKGWKEISVGYRWDETKFPVWFRTSIESEKPEDGERLFLKAVPGGESLVLIDGRSFGEINVYHQFLDLTEFADGKSHVIDIQTVPKGLLGTHLPDPVFEGAELLLQDRFVSSTYLDFTVAIEVLEATRDEFLSEKLLKIISDCLSEIELPRSTDQYFKTAPDNPTLFGHHTYGSVNEIWQSPRFEKSEGNRLTDNYRHTVMKAREKLASNIASLRDEHSAVGTVHVTGQSHIDYAWLWPIDETKRKIRRTFANAVRMMEKFPEFVYLQSSAQMYMDLKENDRDLFERVKEKISQGKWETIGGTWVESDCTISSAESLARQFLYGQMFFEKEFGMRSSVAWLPDVFGFSWTLPQIMKEAGIEYFSTTKLKWNEKNRFPLDLFLWRGLDGSEIVCHFFDNPLGGYNGMLNPEAILGTWENFQDKRVYDKTITTFGYGDGGGGPTDDMVEYYERLKEYPGMPKLEMAPLTKYFKELPSTLELPVWDDELYFELHRGTYTSQARTKKLHKDAEDALYRLEVVGAIVCSREKYPLERARKLWATLLHNEFHDILPGSSINEAHIQAENELGQLIREANQITGTLLDPAGDGNPSFKTVINVGSYPQKAIFIDDNEMNLYDGTGKVLASQRTYDGRFVYSYDHDIQPFSSEVFECFGGKVEEHAMESDPVLENSFLRVEVNSDGSVSVFDKQLQKEVTSGPGNCLYVYKDIPVAWDAWDIDHDYKISGKRLTALDVRTIESGPVRKVVQARYEYEGSSIVQRYILSASSRRLDIENDIDWHTRRTLLKAHFPVSILSREVRCDLSAGYSRRSTRVRNTFEDARFEFPAHRWVELEEPGLAVAILNDGKYGHSCNGSDISLTLLRSPIYPDFFADEGRHRFTYSLFSHDGEDAVRVVEEAEGLNKEMIKINGKIDLGTAVIQISARNLKVLALKHSEKSGYVLRLAEVEGRRGVAKISTALAFERCWISNVLEDKVCELPVIDGKVELPYRQFGLHTLRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C7</accession>
    <name>I2F5C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-54 interacting regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731071.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1444"/>
    <dbReference type="EnsemblBacteria" id="AFK07130">
        <property type="protein sequence ID" value="AFK07130"/>
        <property type="gene ID" value="Theba_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1444"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_7_0"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="119"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="438" mass="49971" checksum="17E4316D8B61693A" modified="2012-07-11" version="1">MLYRKIMVGENLESMQCEMYFESLFDVDFDYLVGLGKEMPTILFIDASKYSEDVLNDWIFAFTNIILINNNPIRAFIIRGYSEERQEFKGYYRVLSSYKSPRQIVQEITSSIDENLDKIIGNSNRVLQMKKMIVLSMFYDGSIMILGETGSGKNLLAEIIAKLSPRGSRPFYSINCAAIPENLLESELFGYKKGAFTGAAAEKVGLIEQANDGTLFLDEIGDMPLNLQAKILAITENREFFKIGATKPIKVDVRFITATNRYDDAAIRNDLRYRLSAVKVDLAPLRERKTDIPQIFDAILEKKGYLVKFENIPQDLKERFLSYSYPGNVRELINMIEEYLAVNDVVQASVNSSMSKNVKLLAEEAMVARMLNGTTYKDFLQEVYKSVSHELLVQRSEVLGNNMNELSKEFGLTTRRIRDLLAEANSYIKDHSTEVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H4</accession>
    <name>I2F5H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731105.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1495"/>
    <dbReference type="EnsemblBacteria" id="AFK07177">
        <property type="protein sequence ID" value="AFK07177"/>
        <property type="gene ID" value="Theba_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1495"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_0"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="129" mass="13683" checksum="5EA25D6D23E513AC" modified="2012-07-11" version="1">MKIKVLVAKPGLDGHDRGAKVVAMALRDAGMEVIYTGLRQSPESIVKAALQEDVDVVGLSILSGAHMKICSKVLKLMKDSGIGDKPVFVGGIIPPEDAEELKKAGIFEVFGPGTSLKSIAEKIEKTVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K3</accession>
    <name>I2F5K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731124.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1530"/>
    <dbReference type="EnsemblBacteria" id="AFK07206">
        <property type="protein sequence ID" value="AFK07206"/>
        <property type="gene ID" value="Theba_1530"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1530"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435332_0_0_0"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="590" mass="67724" checksum="665AB836A583E26D" modified="2012-07-11" version="1">MLKIRVSSIEEFLLADRKEFKMEAGNFVYIYDFERLTDSPGILLRISVVNRSDAPKKVGKIDLLEIEDVSEPVYYNGWQSWLPFKAYWEQPIVDPFVQYADSHEISLFSATPIPEILREGRRPSDYFIATDELVVGFLSSRFSHQYFLWNDDQCNIRGSADLFGAELAPGESVQLEKMVIFGKDSLWSMLENYASLIKKSNKVEFNDFSGVGWCSWYQYFSDITFEQLSKNIRLLAEIRDREKIDYRLVQLDDGYQEDIGDWLETNSKFPELKEIASEIRKRKFSAGLWIAPFSASETSKVFREHQDWFVRNEDGSPRIAYRNWGKKIFSLDTTNPKVLEHLRDLIVSIRRSGFDYLKIDFLFAGAIPGRRYREDCGPIEAYRIGMKAIRDAAGKDCFILGCGAPLLPSVGFVDGMRIGSDTSPQWNGEAMDIGIPSARFSLRNAYTRAFMHRRLWLNDPDTVILRKCEMTEEEKRIFALSVGLLDGMMINSDDMELVDSQGISLLKEAIMLKGGEPRVFLDGMNSVFATCTRKANYCNVTSFVNLTDTPRHSIKLKEMYENWSGVKPPVKEVELPPKSIWIAKSDSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L3</accession>
    <name>I2F5L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">surE</name>
        <name evidence="7" type="ORF">Theba_1540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487144.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1540"/>
    <dbReference type="EnsemblBacteria" id="AFK07216">
        <property type="protein sequence ID" value="AFK07216"/>
        <property type="gene ID" value="Theba_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1540"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_0_0"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="27905" checksum="8A3D72730B5E781B" modified="2012-07-11" version="1">MNILVTNDDGIMSPGIIKLAEALSEEHDVLVVAPDVERSATGHAITIRTPLWAKQVKVGNKNIGYAINGTPADCVKLGLLAISEKKIDLVISGVNKGQNMGIDVLYSGTVSGALEGAVMDTPSIAVSSSDWSNPEFETAAAFMVSFLRVFDVKMMPDFTALNINVPSVKSEELKGWKVTRQSRRRYKDYFEKRKDPYGNNYYWIFGEVVEDECSTDCDYNAVKSGFVSITPLHAIMTDNDYFEKLKEISRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P4</accession>
    <name>I2F5P4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731154.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1575"/>
    <dbReference type="EnsemblBacteria" id="AFK07247">
        <property type="protein sequence ID" value="AFK07247"/>
        <property type="gene ID" value="Theba_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1575"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_0"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sua5_yciO_yrdC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YRDC"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
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        <location>
            <position position="60"/>
        </location>
        <ligand>
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        </ligand>
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        </ligand>
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            <name>ATP</name>
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        </location>
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        </ligand>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="345" mass="38008" checksum="0DFEB043F7580912" modified="2012-07-11" version="1">MNTVYLRVNSEEPDEFRLKKAARFIRDGELVVFPTETVYGLGANALDESAISKIYHAKGRPQDNPLIVHVSSREMVADLVSQNLSEYSALMDTVWPGPVTLIFRKRKRIPDSVTAGLDTVAIRFPSHPVASKLIELSCVPVAAPSANLSGKPSPTREEHVVEDMDGRVSCIILSGSTVFGLESTIIDLSRERPVLLRPGPIDPDQLKGVLPDLQIPGFASGREQYLGDPLSPGLKYRHYSPDIPLILVEGELGLVVSKVGIIAGRKSSLVLCSEELRDYYPVQVKKVVLGSRSNLLEVASNLFKELRDKENMSFSQIIAEPFPETGVGLAIMNRLRKAAWKIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R3</accession>
    <name>I2F5R3_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_1601</name>
    </gene>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="772" mass="86819" checksum="5CF148BC748B4278" modified="2012-07-11" version="1" precursor="true">MKRFMYVVSIVLTIIISLSSCVKPVPPVDTTDLKGVVMTDGEHDGFVRLLSTSDTLIGEESVYRLGGFFYKSDVLLPKSFLIEASITFGEMELDYYYEVSDLGPDEIIYIGPISTLIHKYHLKHPEKSLNDVRGEVLIFLSIDPGHSDYTIAMNRGKFSITNFMNSALAHGGFDSFIDFLVDDLSVGGGPHDFGDYEEDPEASIFESLIGELNENLESSAIDYATGWVFDMIGGGNGDNPEADIEKLLELQLEMLKDIKTELDQIEEELKEAVNEIISAVDKSTYNTAVTVIADEVGTIEAKYQNIVYYAALDPDKKYESDIELLSRQIKDEIPNSFMTIRDVLEGRAGAESLFSLWSRIAFKDASDISEYVAMISSQFSYYFALQLKAINLMVEVYHAEDPANVGMAASCFNDWLNNLRDELDLFNTFNPISELATSTTFPTINTVDDWFAWPDISSMFLVGDRIVVTDGGWVQAPTEDPNIEIYSVDSMTLQDRHKYSQISLSYRATAVDDTNLYLLYHLQNNNYRLYKSEVDASEEDWTYSDFTLEHGCLQMAANSQWIFILGGDRDGFYLNIRDKATLAHHKTVQLTGSSGYSSQSVAMTSDGDYAYFLFSNGNKLLSVDLKTLEILDTINFGSTISDFPNMIVRDDILCVSTAYHDVFFVDTSDKADLNLFKTIEFDPNQADQCSPLNVNFAGNFTYAAGAMPWVIYVVYDNPRNLTGPMFKENMSAQSLLNWQPLLMNGEDELYILGNSNTLQLWKKYVVVDIPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S1</accession>
    <name>I2F5S1_9BACT</name>
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        <submittedName>
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        <name evidence="2" type="ORF">Theba_1610</name>
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    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1610"/>
    <dbReference type="EnsemblBacteria" id="AFK07274">
        <property type="protein sequence ID" value="AFK07274"/>
        <property type="gene ID" value="Theba_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1610"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013410">
        <property type="entry name" value="CRISPR-assoc_RAMP_Cmr4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
        <property type="entry name" value="PTHR36700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="266" mass="29362" checksum="1B3CC8BF54769AB6" modified="2012-07-11" version="1">MKAFCLYAESQIHAGTGADVGIVDLPIQRERTTGFPVIQGIKGALRASGLIKDDTVFGSKPSKGGEENTDAGKISFSEAKILLFPVRSAEKMFVWVTCPIVLRRFARSTGKKLEVPDVQNGKVILADQNFNEKSLMLEELELQFEKNPEVASIAAFLSSCAPDSYMATKLKRDLVLVSDDLFAKIVKTMTEVQPRIRIDEKTGIVVSGALWYEEYLPQDSVLYFTARETVYSKGSESKLSELDEKTMIIGGKETTGKGFVFVKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T3</accession>
    <name>I2F5T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1622"/>
    <dbReference type="EnsemblBacteria" id="AFK07286">
        <property type="protein sequence ID" value="AFK07286"/>
        <property type="gene ID" value="Theba_1622"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1622"/>
    <dbReference type="eggNOG" id="COG1857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068035_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013414">
        <property type="entry name" value="Cas7/Cst2/DevR_sub_I-B/Tneap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01905">
        <property type="entry name" value="DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02585">
        <property type="entry name" value="cas_Cst2_DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="32202" checksum="11CA83B12BC24C33" modified="2012-07-11" version="1">MQIKCLSWGSISKVTMGNPNAGFTEGNIQTAKKIVAPDGSAFNYVSGQCQRHGLRERFAEIGEALSTPVDGEVETTLGDPLNYIDDDLFGFMIAVTGDNRKRTSPVRIAPLVSLFPYRGDRDLLTKTRKASDKGGNMVETEVYSAYLRGGGLIELDRVGKFDPSEIKETTLEIQKEERLRRLNLFLDSMMTLWTGGKQTNILSDISPKFIAFAFQTVKLPFLLESVSCDTKGKINAETLIDSITNYSSIIDRVIIGTTKVLDASALDAGVPETVEVLPMTDAFSRVKEILSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5W8</accession>
    <name>I2F5W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1658</name>
        <name evidence="8" type="ORF">Theba_1735</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
            <strain evidence="7">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1658"/>
    <dbReference type="EnsemblBacteria" id="AFK07321">
        <property type="protein sequence ID" value="AFK07321"/>
        <property type="gene ID" value="Theba_1658"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07392">
        <property type="protein sequence ID" value="AFK07392"/>
        <property type="gene ID" value="Theba_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1658"/>
    <dbReference type="KEGG" id="mpg:Theba_1735"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="32431" checksum="653DC9F04F858CB0" modified="2012-07-11" version="1" precursor="true">MDMELITTLFRTSIRMATPILLASLGGALTYHAGIINVAMEGLMLISAFFSVVFSYLTGNAFYGIIAGMMASILISLLYSVFVSFLKANNFAIGFAINILVSSLTLFLMRIMFKGENAFNSPDIAPIPELKLITGNYFLDNYILNFSILTYLSILIAFVLAFIVYKTSFGLRLRVCGEMPQALTTAGVKVGFVQLCSSVLCGALCGLAGAQLSLYNVRMFSREMTGGRGFVALAAILISGGKPKRILVISLLFGVFDALSVKLQGEKVAPQFALMLPYVMSVVVLLLFHLKSRKGLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D1</accession>
    <name>I2F6D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488383.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1833"/>
    <dbReference type="EnsemblBacteria" id="AFK07484">
        <property type="protein sequence ID" value="AFK07484"/>
        <property type="gene ID" value="Theba_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1833"/>
    <dbReference type="eggNOG" id="ENOG5032RD1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1765857_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="16500" checksum="94D9E3CA78DD4A8E" modified="2012-07-11" version="1">MRALCALMEREMAPKKIGWYEGFNGRDSLFGFVSYAEEIPVAFFEVMPSLLSPYSIPKSLSTALISCIYNSHDSTYDYRSELIQLSVEECRKRGFGSVEALSGKKSSFSNGLASFFLQNGFEDLETVDSSVIMFSGRDDIDLLIRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I0</accession>
    <name>I2F6I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488272.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1883"/>
    <dbReference type="EnsemblBacteria" id="AFK07533">
        <property type="protein sequence ID" value="AFK07533"/>
        <property type="gene ID" value="Theba_1883"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1883"/>
    <dbReference type="eggNOG" id="ENOG502ZFDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2898359_0_0_0"/>
    <dbReference type="OrthoDB" id="2095733at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="66" mass="7243" checksum="894524881D50FC07" modified="2012-07-11" version="1">MEVVYGNNRWSFDRDLTFSELIEETQLGSVSPLVLVDGRFVGEDELISAKSRVLIIVAANADQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I5</accession>
    <name>I2F6I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731340.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1890"/>
    <dbReference type="EnsemblBacteria" id="AFK07538">
        <property type="protein sequence ID" value="AFK07538"/>
        <property type="gene ID" value="Theba_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1890"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249407_0_0_0"/>
    <dbReference type="OrthoDB" id="1940570at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="221" mass="24964" checksum="8A63420C92059877" modified="2012-07-11" version="1" precursor="true">MKRRTTLIIGLIVIFLTATIFASTVRIKGDTVLGSLQKEVFTFIGNVFINKDGDIYVETPLATATKGATDWESFVTEGETFVRFQTGEATALSLDYNLENSTGTLFGNVEAVIYSKEEDGKDIFIYETEILNFDQKTEYYEGFAEETAEATPELIFINYKGDLNVDTLYFEYFGDTGLLNLKGNVFVDDFKNSRKIWASELIYDTTDDSFEGKNVEIELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M0</accession>
    <name>I2F6M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731375.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1927"/>
    <dbReference type="EnsemblBacteria" id="AFK07573">
        <property type="protein sequence ID" value="AFK07573"/>
        <property type="gene ID" value="Theba_1927"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1927"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_3_0"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="95" mass="10661" checksum="606D6BF9448DCA65" modified="2012-07-11" version="1">MNKRTVMLFKALGCSWRLKILEQLSKGTLCICELDDLFAIDKTTLSRHVKALVDAGLVKENRNGARKELSIADRRVLEIVELAKSITDVSSQESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R0</accession>
    <name>I2F6R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731405.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1970"/>
    <dbReference type="EnsemblBacteria" id="AFK07613">
        <property type="protein sequence ID" value="AFK07613"/>
        <property type="gene ID" value="Theba_1970"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1970"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="OrthoDB" id="632656at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="388" mass="43366" checksum="C05CC4E7171B6A69" modified="2012-07-11" version="1" precursor="true">MTDRNLAIVKIVSCVLVGIALIISGVEFYNHRNFKEPVVVGSGVTEVKTLGDYFAPLKGTINDTNIYIIDSGVPGGTAMLIGRSHPEEPATNLAAKIFVENAKLTKGRLIVVITANQSASRVTRPGDAYPMYYTIETPWGESKFRMGDRWSNPLDSWPDPEAYVHYPSGQLLAYMDIRNFNRTWPGRENGMITEQTNYAFMNLIREENVDIFIDLHEAELEYPVISTIVAHQKAADIAGLASMILTSSEFRIGMEFSPPSLHGLSHREVGDHSDAISLLFETPEPFLDRVRGITDEALLLTGKDEFVMTAGKFGLLYEKIDENGWPIDVRVGRHCSSTLMVIELWGDFNPGKEVVIEGVPRYDEVVSNGTGYYFHDPSKARTQDIYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T6</accession>
    <name>I2F6T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731428.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1996"/>
    <dbReference type="EnsemblBacteria" id="AFK07639">
        <property type="protein sequence ID" value="AFK07639"/>
        <property type="gene ID" value="Theba_1996"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1996"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_0"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="291" mass="33227" checksum="3D41B5BBA7C90704" modified="2012-07-11" version="1" precursor="true">MQRAASSMLKKENSLGWKLVSPTVILLMILILYPVGYNIYISFFDYGITSSTFVGLENYVRVFKDSAFWKSFFITVGFTLMTVVGSIILGLVVALMLNKEFKGRAIVRTIVLLPYITPLISIVFSWKYIFDPSYGPFMQLFGQTLGWVSPQLDLLNNSNNAFLVASVFNIWRNFPFVYLMLLSRLQSIPDDYYEAAEIDGATSWKQFTNITLPELYFVMGAVALMRGIWNFYKFDEVYLISKRAGTLPIFIYERVIGTTSPEYGVAAAIATILMVIMLFLITVYVKKVLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U0</accession>
    <name>I2F6U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731429.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2000"/>
    <dbReference type="EnsemblBacteria" id="AFK07643">
        <property type="protein sequence ID" value="AFK07643"/>
        <property type="gene ID" value="Theba_2000"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2000"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699825_0_0_0"/>
    <dbReference type="OrthoDB" id="1697979at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="194"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="394" mass="44156" checksum="1E782E662CF41A8F" modified="2012-07-11" version="1">MKSDTHSVCLYGSAHDLRKAINTFLKEGLSKNYKLLYFGPERDVIPSKETTDGLPYNLDDLLGSKTLEIIDFEKSYVKNGVFDPVRQISFLQEAAVRAIKEGYNGLGVAGEGTAILESGTKMEELLKYEASVNDLVEESPVTAYCLYDSSRIDQSSALEISRLHPYTLRESGFSVNEDYYRAPRRTLEYDTASRLDICRGTANSLLQMFRMKSIYVEEHEENVSKLASAIAKEMALDSFTMACLEMAGKIHDLGMNSMFLDMLTRPGPLHALEARLLRRHPITGFEISRGVPFPDKVSYAVFQHHERIDGSGYPNGLKDSEISLEGSILAVSEVVAAMSFYRPYRKPYGQEYSLDQIVKYKGSLYRTEVVEACLTAFENGFSFESSLKTSASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F738</accession>
    <name>I2F738_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-Lysine 5,6-aminomutase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731515.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2107"/>
    <dbReference type="EnsemblBacteria" id="AFK07741">
        <property type="protein sequence ID" value="AFK07741"/>
        <property type="gene ID" value="Theba_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2107"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517447_0_0_0"/>
    <dbReference type="OrthoDB" id="346908at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="1">
        <location>
            <begin position="5"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="520" mass="57842" checksum="05077EC399241945" modified="2012-07-11" version="1">MNGKLNLNMNKVKEARDYAQRIASEVHNFVEEHTTVSIERAICRFFGIDGVDDYGIPIPNVVVDHLKSSNLINDGAAYVIGNAILETGLSPQKIAEEISFGRLDLRSLSYRSQDEVFDRIDRLVNDAVGKVQLNREKRESLIGELGEGKKPYLYVIVATGNIYEDVIQARAAARQGADIVAVIRSTGQSLLDYVPYGPTTEGFGGTYATQENFRIMRSALDDTGKEVGRYIRLCNYCSGLCMPEIAAVGAIERLDVMLNDALYGILFRDINMKRTLIDQYFSRVINGFAGVIINTGEDNYLTTADAFEEAHTVLASQLINESLALMAGIPEEQMGLGHAFEMDPSIENGFLYELAQAQMSREIFPKAPLKYMPPTKFMTGNIFMGYAQDTLFNVISIMTNQGIQLLGMLTEAIHTPFMSDRYLAIENARYVFNNLRDLGDEITFKDNGVIQTRAATVLEEALQLLREIESIGLFETLERGTFANVKRSPHGGKGLDGVVRKGSKYRNPFIEKMLGGRNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F740</accession>
    <name>I2F740_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731517.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2109"/>
    <dbReference type="EnsemblBacteria" id="AFK07743">
        <property type="protein sequence ID" value="AFK07743"/>
        <property type="gene ID" value="Theba_2109"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2109"/>
    <dbReference type="eggNOG" id="ENOG502Z9AE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065107_0_0_0"/>
    <dbReference type="OrthoDB" id="1482071at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="334" mass="36774" checksum="32CF76207224E72C" modified="2012-07-11" version="1">MKRRIRISDLAEGIEVISVIGLEKNTGKTVVLNQMLKEFREKGTTAGVTSTGLEGEKRDQVYLNEKPEITLSRGTYFVTSERDFRHRSFSATVIDLRDYRSPLGRTVFARAEADGKVIISGPSILEYLSEAVNTMRSYGCEKILIDGSTSRMSPGTPLVSDGVILATGAALSMNLEELCRKTSFVVRLLSLPGTELELHKRIAPLGTGLWVEKDGVFERLSPSPLTAKSLKHELAGRTIYINGSLTCSVLLALAEKNTRIILKDFSQVFFDELTLAKYERAGGHLEVLHPTHLIAVTVNPLAPNGFKIQSDKLIKSLESKIDVPVLDVLEESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F796</accession>
    <name>I2F796_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2166"/>
    <dbReference type="EnsemblBacteria" id="AFK07799">
        <property type="protein sequence ID" value="AFK07799"/>
        <property type="gene ID" value="Theba_2166"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2166"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_3_0"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="22458" checksum="5B4DAA897854A907" modified="2012-07-11" version="1">MEVIRLLAKALDENCYVVREDERITIIDPGYGVSTELAAFEDKKHLRALLTHGHADHIFDLDQIETDEIIIHPMDKPMLLDAEKSFLNLFGKNALLLGGKKVLSTEVLRDRWKCLHTPGHTEGSCCFLFDERFLFSGDTVFSASVGRTDLPGGDHDQMTSSINRLKELFTKMPDLIVFPGHGRQTTARIILRENPFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B0</accession>
    <name>I2F7B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731578.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2180"/>
    <dbReference type="EnsemblBacteria" id="AFK07813">
        <property type="protein sequence ID" value="AFK07813"/>
        <property type="gene ID" value="Theba_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2180"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_24_2_0"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="133" mass="15071" checksum="6878BC7782381F0A" modified="2012-07-11" version="1">MAEENYSFTVEPELYKIDAFSAKVSEIVRRTKGNETGFRAGLIVIEACSNIVKHGELKEDDLISVNLEVGEEEVTITIEDASTEFNPLKVDDPNLENIELLQKGGMGVYLIKRFSKRVDYRYENGKNLLKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E2</accession>
    <name>I2F7E2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ORF">Theba_2214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731605.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2214"/>
    <dbReference type="EnsemblBacteria" id="AFK07845">
        <property type="protein sequence ID" value="AFK07845"/>
        <property type="gene ID" value="Theba_2214"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2214"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_0"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="9"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="284"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="368" mass="41110" checksum="365A80D11FF17AB1" modified="2012-07-11" version="1">MSELKRTPLFDEHVRLKGKLVDFAGWEMPLQFDSIINEHNLVRKVAGLFDVSHMGEIEIAGPDAIDFSDYLVTNSVSSLKNGAIVYSPMCNEKGGIVDDVLVYRLNNAKTMFVVNASNKDKDFKWITSNKGSFDVKIKDASADFAQIAFQGPRAEEILSEVSQVRLEKIPFYHFEYGRVNGIKALVSRTGYTGEDGFELYVDPEAAVALWRKILELGSSIGVKPIGLGARDTLRFEAAYMLYGNELNDYNSPLEAGLKWTVKMEKDFIGKEVLEEQLANGTKYKLKGLELSGKSIARHGFEVFDGEKKIGWITSGIFSPTLQKSLALAYLEKEYWKIGSEVQVEIRGKRSPATVVKTPFYRGSVKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J7</accession>
    <name>I2F7J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731659.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2271"/>
    <dbReference type="EnsemblBacteria" id="AFK07900">
        <property type="protein sequence ID" value="AFK07900"/>
        <property type="gene ID" value="Theba_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2271"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044700_0_0_0"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="55"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="41245" checksum="6863E05F18085B0F" modified="2012-07-11" version="1" precursor="true">MSNWNILFNDSLRNFFGTAIKIAVKNPAQIAFMAKTAKNQREAAAVRDRFEAEGLHVPPVMIASITSKCNLNCVGCYSNAKKLRTDREITASHFRSILEQSVELGISIVLMAGGEPFMRKDILQTAAEFPQILFPVFTNGTMIDDNTVEWLKEHRNIVPIVSIEGNEGDTDTRRGAGIYRNALEVIASLKESGSFFGVSITATSQNHIKITERRFVNNVVKLGAKLVFYIEFVPLTPGTMNLVLNQEQKLELADRIDALRKNSASLFVSLPGREATYGGCLAAGRGFIHLSPEGFVEPCPFAPFSVHNLKETSLREALESEFLKVLKENHMKWKSKDGGCGLWSNREWVESVRQSTTVEKEAIQETVSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L3</accession>
    <name>I2F7L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731671.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2288"/>
    <dbReference type="EnsemblBacteria" id="AFK07916">
        <property type="protein sequence ID" value="AFK07916"/>
        <property type="gene ID" value="Theba_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2288"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715335_0_0_0"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658422" evidence="1">
        <location>
            <begin position="25"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="386" mass="41364" checksum="334558E62BF41457" modified="2012-07-11" version="1" precursor="true">MLRKSLAIVLLVAFLIVAGSAALAAEKFREVPLELIQLMEKQFHQVWTPAGPSGEEVRGAGDLELTAEEIEKAKSLDLGQYYFMGASLDMTETLNRFGMNKVLASIGKPEISFMGSNSIADQIDQVTTLAGKADEIGFVVAQAWEAVTLGPSFVELAKAGVPQLHNWTTPAGLENEEYYVGLVDADGYGQGAAAAEILAYAMGYKGEVGLIYFALEQWTNVMRLKGAEDTFAKYPDIKVVGKAGFTDPSQSFDLAIGLLQKYPEIDAMWGTWMMGVATGAAEAVLSLGRLGEVVVAAPDLGGKAGAQYIADPENPIIGAAEADCIEMGENSVNAAIKWYLGNTDIAQGYFVSRVYPVVKANLVDVYNKTNLEAIGELPQDVLDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L9</accession>
    <name>I2F7L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731677.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2294"/>
    <dbReference type="EnsemblBacteria" id="AFK07922">
        <property type="protein sequence ID" value="AFK07922"/>
        <property type="gene ID" value="Theba_2294"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2294"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_5_0"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="380" mass="41549" checksum="81740C3B19B0F497" modified="2012-07-11" version="1">MRNLHFTERERVILARIRNEGPIARVRIAKKENISKPVVTLGVRKLLSVGAVREVGKDVKRSSKGGKQATLLGFVADFRLTLAVDIGRTKIVAAMIDLDGNIGASHTVSLRENMSKEEFMSLLFEAIGGVIEVGPKEKIIGIGVGIPGVIGSNNGVADFIPVLSLRNVPIKSWIEEQFGIETFCENDAALQALSESWKGVAEGKKNVVVINLGAGIGSGVIIDGRLYTGSTGRAGELGYLISNWDNTYYRESFFGELEEKLSGVCLERKLDEFGYHGFTATDLFERDIDDERLRDLIYQGCKSLALALCNLISILNPDIVVMTGGIGYNQFELLTKYTIPLIKNILPNEFVGSVDFARSKFPSEGVLIGAGYLVQKKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N6</accession>
    <name>I2F7N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07939">
        <property type="protein sequence ID" value="AFK07939"/>
        <property type="gene ID" value="Theba_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2312"/>
    <dbReference type="HOGENOM" id="CLU_3185659_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="46" mass="5135" checksum="1C282DEC878B01AC" modified="2012-07-11" version="1" precursor="true">MRRTNFFLLLVLSTLVLGLEPITLRIGDTSATYYREGSLSIFSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R7</accession>
    <name>I2F7R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731720.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2345"/>
    <dbReference type="EnsemblBacteria" id="AFK07970">
        <property type="protein sequence ID" value="AFK07970"/>
        <property type="gene ID" value="Theba_2345"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2345"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="251" mass="28214" checksum="3AFC2E4A4925D50C" modified="2012-07-11" version="1">MISCKKLTKVFDKDPVVNEIDLSISSGEIYGFLGPNGAGKTTTIRMLTGTLKPTSGEVKILDMDFSRNELLIKSRIGVVPDEPRIYSYFTGAEFLEFIMDVFPDKKQEAKKRVGELCEAFGIDYLGKMISEMSHGMKQKIMVISVLMRRPEVIFLDEPTVGLDARSAKILKMLLEKYKNEGSTIFMTTHVLEIAEKMCDRIGIINKGKLISEGTMNELRRKAGADERETLENLFLQLTGEDEDIQEIVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T5</accession>
    <name>I2F7T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731735.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2367"/>
    <dbReference type="EnsemblBacteria" id="AFK07988">
        <property type="protein sequence ID" value="AFK07988"/>
        <property type="gene ID" value="Theba_2367"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2367"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="291" mass="32911" checksum="C9161545E8F77E03" modified="2012-07-11" version="1" precursor="true">MKQKTRKGLFGFIFLLPVIVMISIFFIYPLIKVVLMSFQEWKIMGGSSFVGLSNYKKALVDDEFWKTLWNTVIYAIIVTPMIFVPAVLLANALKKTSRSTKIFRTIFFIPYAISFVAASYIWQWIYNDSYGILNYILISLNLIGQPINWLGQTWLSRVMVSIMVAWKTLGFTMIIVIAGLQGISPQIYEAASIDGAEKSQVFRYITLPLLRPTLVLALILSLAGSFKAFDHFYIMTKGGPLKTTETIVMYINKIGFEFYDIGFGSAVSVIFLGILLLISYLQLKAGGFQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T7</accession>
    <name>I2F7T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731736.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2369"/>
    <dbReference type="EnsemblBacteria" id="AFK07990">
        <property type="protein sequence ID" value="AFK07990"/>
        <property type="gene ID" value="Theba_2369"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2369"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016354_0_0_0"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="647" mass="75190" checksum="1BBE1ECD176B8ADF" modified="2012-07-11" version="1">MIDVELMELPLGEIRPAGWLERQLKIQAKGLTGRLEEVWKDVGPDSGWLGGSGENWERGPYYCDGLIPLAYLLEDEKLKGKAAKWISWTLESQNEEGFFGPRDNDDWWPRMVMLKVLKNYFEYTKDQRVVHFMTRYFMYQLQNIDSREFAIWENTRSVENIYVILWLYSITGEGFLIDLAKRFFEKSMNWSNYFENFKYTKPTGEYLDWEKFMKATGGKGLEGLYEYEERTNSTTYSKLFQETHVVNVVMGVKYPALRYLLYGEKNQLKIVKEGIKKLIDYHGTSNGMVTGDEHLNGNDPSRGTELCAVVEYMFSLEILFRVFNDTEFADILEKIAYNALPATIDKELLTHQYDQQVNQIMCSHAKRNWYNNLDDSNLFGLEPNFGCCTANMHQGWPKFVKNLCYKSDDGGLVFGVYGPCKIETSVAGQTILIREVTDYPFDDKIEILIDNNADFEIPLHFRIPGWATKSEVTLNGSAFDPENNEGYLTIKRLWNRGDRVELVFRSRVRTSKWFKNSLSVEKGPLLFALRLDEKWNTTNKDGEFPEYEVYTTSPWNYALKVDLKNPEKSFSFIKRTQQLSEQPFDQNLVPVLIEADAAKVEEWSWERNSAGTLPESPVRPEGPLEKVCLIPYGAARLRIAQFPYFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V2</accession>
    <name>I2F7V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489976.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2387"/>
    <dbReference type="EnsemblBacteria" id="AFK08005">
        <property type="protein sequence ID" value="AFK08005"/>
        <property type="gene ID" value="Theba_2387"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2387"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_3_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="98"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="347" mass="38338" checksum="FC374243833E4F98" modified="2012-07-11" version="1" precursor="true">MATFIIRRLMFLPLVAFVVTLVVFAVIWSMGPDVLLRAYMTGNASKSPNAEQRIVEKYGLDRPAVVMYFKWFGNTLRGDMGYSLTAGSRVSEAILVRLPASLELLILALIPIILFGSRLGIRAAMHPDGFTDSVFGFLSIIGWATPDYVMALLILVGSFTIFGWLPIGNLTTSLIKDWNTYSNSLIIDSILNLRLDILLAQLVNLIQPVLTLFIVHSAYVFQISRATALEVKKKDFIRAARSRGVSERTIMLTHVRRNALIPVVTVGGELFASLFAGLAFVETIFARPGIGRLLTEAAISFEVLTLSGLVLLIAAVMLLVNIVVDIIYSYLDPRILLWDNGKSERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W5</accession>
    <name>I2F7W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731760.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08018">
        <property type="protein sequence ID" value="AFK08018"/>
        <property type="gene ID" value="Theba_2400"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2400"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034454_3_0_0"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="48078" checksum="A075C6B79C07CE22" modified="2012-07-11" version="1">MAKLNLSDLLIPMSKRVKFEEKIGLVLSGGGARGAYQIGVWKALKDCGIEIGGVYGTSVGAINSMAIAMDNFEDARQLWLKIDFDKVVKDGPDGNLIEKALAALKSRGFDPAPLRENFGRLLKEELVRKAKIDVGIVTYSLSNMQPKELFLDDIPEGKLEDYILASANHPVFKREEIGSEKFIDGGIYRNIPVNMALSRGFKEIIIVDLGPKRIRDVLTLTSLKRLEEVKYLVIKPREFYGDVLDFDPDIARNFMREGYLDCLDELGYLNGEEYFVFAKHDAIARALFSLPKKKKEEARAIFGVEPWQSESTQHFYYGQLMPVLQDHFGIFNPVETWVRLLEDLARYLELERLDLYSLYSFTKEILSSRNVGVEGRNYNDISCESILNFLEFLVKNSDLESLEDREFSVFREGFLSLTNLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z8</accession>
    <name>I2F7Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1479518at2"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="37131" checksum="B402482FAA23B37F" modified="2012-07-11" version="1" precursor="true">MNFGQFLLRRLFLMIIVLFGVACIVFFIANVIPADPVGAILGGNAPPEAVDRLKAKLGYDQPLIIRFGNFITGAVRGDFGISLKTSNPVMEDIRNYFPATMELALVAITISIILGITLGILSAVHRNKAIDQFSRIFSILGVSMPVFWIGLLLLLVFYFKLGWLPGSGRLGFFTYPPPRVTGMYLIDSIIAGQWDTFKEALMHILLPAFVLGYNATASIARITRASMLDVLRQDFIRTAKSKGLRKNVVIYRHALRNSLIPTVTIIGLVFGSLLEGAVLTETVFSWPGLGRYITTGMLFLDYPAVMGGTLYIALIYSIANLIVDILYALLDPRMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F809</accession>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="172" mass="19910" checksum="78278D5CD9BB86A1" modified="2012-07-11" version="1">MRGKPVIVAEYDSSWPELFRREAELIYAALEGVEMSIEHIGSTAVPGLQAKPVIDIMIGVSSLEQADSCVPFIERTGYLYRPEHEDSMPERRYFERSGSEIDCHVHLVVFGSKFWRGHIFFRNCLRENPEIVQQYAALKKELAEKYRDNREAYTNGKAEFIQGILRRQKDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F870</accession>
    <name>I2F870_9BACT</name>
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        <submittedName>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08123">
        <property type="protein sequence ID" value="AFK08123"/>
        <property type="gene ID" value="Theba_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2516"/>
    <dbReference type="HOGENOM" id="CLU_191482_0_0_0"/>
    <dbReference type="OrthoDB" id="2043005at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="67" mass="7695" checksum="0A227F2C6832FA31" modified="2012-07-11" version="1">MIYYVDDNAKPTGEHEIHTEYCDRLKELKSKTRLGDFVNCFGALQKAREIYPNVDGCIHCCSECHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F891</accession>
    <name>I2F891_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2542</name>
    </gene>
    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
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    <dbReference type="STRING" id="660470.Theba_2542"/>
    <dbReference type="EnsemblBacteria" id="AFK08144">
        <property type="protein sequence ID" value="AFK08144"/>
        <property type="gene ID" value="Theba_2542"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1918376at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="178" mass="19233" checksum="09AF099066E60891" modified="2012-07-11" version="1" precursor="true">MAEAKKFDWISLLVGFVLIIGGIFSLSNPLATFLTLAIMLGIVVLVRGIMLIVAYFKLENRTGAKVFFALILGILLAITGVIFLFRPLFAANIFAFVIAIWFIVDAINNLINADRLKPAGKGIYFLSIVFNVLVLFGGIILVLHPLIAGLSVAVIIGITLLVFGVNHIVLAFMGKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A0</accession>
    <name>I2F8A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
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    </feature>
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        <location>
            <begin position="52"/>
            <end position="76"/>
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    </feature>
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            <begin position="88"/>
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    </feature>
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        <location>
            <begin position="133"/>
            <end position="155"/>
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    </feature>
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        <location>
            <begin position="167"/>
            <end position="188"/>
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    </feature>
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            <end position="216"/>
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        <location>
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            <end position="275"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="281"/>
            <end position="304"/>
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            <begin position="425"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
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    </evidence>
    <sequence length="445" mass="48135" checksum="B5999D3471F8CBCB" modified="2012-07-11" version="1" precursor="true">MKRVNILNENMMSALFKLAWPAVLTMLFQTVYNMVDAYWLGKLGKIEISAPTIAWPAIFLLISIGGGLAVAGLALVSQNLGAGRKEEATHVAGQVISTSFAVAVVLGLLGAIFSEAVLRLLSIPPELLSVTNIYMRTIFLGAPFTFTMFTFNSLFTAIGDTKTPMYLMGFSVTVNALIDPLLIFGIGFPRLEVFGAALATVISRGVVVIIATVILFKGKRGFKINLRDLRPKWKTLVRVLRIGLPSSAGQSITALAFLIITSMVAGFGSVATAALGVGNRITSLATMFSFGLSQATSSMVGQYLGAGRKSDAYSVVWKATGINVLIVGVISTGTFFFGKEVTAFFINDPLVLIEGEKYFRIVSFSIPIFASYNIFDMALRGSGHTVQSMILNITRLWGIRLPLIYFFGMSMGITGIWYAMFVSNLVISSAAAIVIFMKRWLNPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A1</accession>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
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                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="entry name" value="SSF53822"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="367" mass="39108" checksum="518E66E87B8BA2E7" modified="2012-07-11" version="1" precursor="true">MRKLFVILLVVFLSVSALASIKVGAILPMTGGVAAFGQMIWQGVELANELFPEVLGEKIEIVLLDNNSDKVQAVNTARRAIEQEGVVAIIGQVISSNTIAGGTVAEENGVAMVSPSSTNPLVTQDKKYVSRVCFSDPFQGVAAAMLAFNNMGAENVAVFVDVEQDYAVGFANYFKETANELGGSVFYEYYKSGDQDFTAQVSDAISKGAGAFFIPGYYQEIALIAIQARQLGFYEPIIAGDGAAVPETIEIGGDAVNGLYFTTHYDAGSPAITENAKLFVEAYTAKYGEAPGTFTALGFDTYLVVRDAIERAGSTDREAIAKAVRQTKDFPAVTGIITIDENGDAIKSVAIVKIENGKFVYDTTINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A2</accession>
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        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC-type transport system, permease component</fullName>
        </submittedName>
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    </gene>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
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    </feature>
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        <location>
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        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="313" mass="33733" checksum="2439E5373B0F1EEB" modified="2012-07-11" version="1">MDPKTLLQNFINGLSLGSLYALIAIGYTMVYGILRLINFAHGDIFMMAVYFALFFVTLAQLPWYLAAILAVACAALLGFTVDRIAYKPIRNAPRISALITAIGVSFFLESLAVVVFSGIPRSFRTIFPQSLNEMIIIGGEMEVKYGREVIVGGIRFPVISLITLIVAAIALVFLWWFIFKTKVGMAMRAVSLDIQTTSLMGVNVDRVIGMTFALGSALAGIGGILWAIRYPQVWPYMGFIPGMKAFVAAVFGGIGSVPGAVLGGLILGITEVMMVGIMPGAAGYRDAFAFFILIIVLSIKPSGLLGRPEIVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J6</accession>
    <name>I2F8J6_9BACT</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Swithers K.S."/>
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                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2649"/>
    <dbReference type="EnsemblBacteria" id="AFK08249">
        <property type="protein sequence ID" value="AFK08249"/>
        <property type="gene ID" value="Theba_2649"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2649"/>
    <dbReference type="HOGENOM" id="CLU_1487382_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="181" mass="20119" checksum="D7C85C3E298CFB82" modified="2012-07-11" version="1" precursor="true">MKRIAVFVLILGMASALVATHFSVGMGFVLNQNRQTKEFDLQFFGRTQVGWMLFSKPVLGIIADVPVFGFGFEEMEFYSLDPTQSLIGLYAELGLEDLASSLPPVFFKVTAMTELSSILAARDIKYLPLVSHIGAGFDMSDFSLELATSIINVGFNLGDQLARHSTFFPHFHLAGRYNFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M8</accession>
    <name>I2F8M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731976.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2682"/>
    <dbReference type="EnsemblBacteria" id="AFK08281">
        <property type="protein sequence ID" value="AFK08281"/>
        <property type="gene ID" value="Theba_2682"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2682"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007643_0_0_0"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="276" mass="30833" checksum="B8C861D60CB6F28D" modified="2012-07-11" version="1">MAVSFMVANDDIPAGAKVTGLTGRLEETIPALVEAGFRFFELMIADPGKVEIEKVKRLEREHSAKCIFLCTGEMAGTAGLYLNHIDINERRRAVNSFMSAARKAYELGVDLNIGRLRGVIWSDGLQKSLDRLAESLTEIDTFVKNELEGLSVLIEPLRKVVCPILNNCQEAADFFETRGLSSYGILVDSDHFNEEVDSSFVSSNIGLVKHVHLADSNHKPLGQGTIDFHKFLNLLTQSGYRRNFSVEVFCDEDQIETLNDTRIFLRELSLLKEGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S8</accession>
    <name>I2F8S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTHEBA.01</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
            <plasmid evidence="1 2">pTHEBA.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003533">
        <property type="protein sequence ID" value="AFK08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732023.1">
        <property type="nucleotide sequence ID" value="NC_017935.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08331">
        <property type="protein sequence ID" value="AFK08331"/>
        <property type="gene ID" value="Theba_2738"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2738"/>
    <dbReference type="HOGENOM" id="CLU_613663_0_0_0"/>
    <dbReference type="OrthoDB" id="1140420at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Plasmid pTHEBA.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="446" mass="51495" checksum="ECAEAA5F7DFA9F09" modified="2012-07-11" version="1">MGKSKNEKTRLRVGALEAGVVISKLVSSSIANPTRCNQSNLKAEIKNDFEADSLEDASNAALLRYEADEYYGIGDAPDHSNTGAQSRKRGKYSVVSSGIDSLYLTIQLSERSHGDLLAGIRENTDSRLGIVSYWEHKWHEMKVSVKESGGYRLGLDDGYIRVLLAETWNENMPCIKIGISSELLHRFNLSECWDMVKRMFQDLKVISIKVNRADLYVDVAGLSLEKIKRENRVCYSGKYAMYEEKGKITGHSFGTRGNDIYCRIYDKLKEITDVSHKGWMCDIWSKSGWSGEEVTRVEFELRRGFFRDIECSTIDDLFLLNLTDVWVTCSKWLSFRIDGDIRLKDREVAEYWKFVADSWGEGVKLKRKRRSGDIRERIKNADRRLLAAVADSSGYRQETISETFDRVIGYMRMPSIRRAFYSRQWKRWSEREVIDSSEKHYQLVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H7</accession>
    <name>I2F1H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729960.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0026"/>
    <dbReference type="EnsemblBacteria" id="AFK05780">
        <property type="protein sequence ID" value="AFK05780"/>
        <property type="gene ID" value="Theba_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0026"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_4_0"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="4">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="166" mass="18701" checksum="BD518E0175F94486" modified="2012-07-11" version="1">MKVIAVFASTLNGKISLSEDDKTEWTSREDKRYFKSLTSSVGIVIMGRKTHEAIGRALPDRLNIVLTRNPDYYRPSENLIFTSSTPKELLEDLEKKGHDEVCLIGGAETFDHFADLGLVNELHITFEPIIRTGIAGLGETMERDLDLSLKEFRKLGEAILTVYEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K0</accession>
    <name>I2F1K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729978.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0052"/>
    <dbReference type="EnsemblBacteria" id="AFK05803">
        <property type="protein sequence ID" value="AFK05803"/>
        <property type="gene ID" value="Theba_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0052"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_0"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="17234" checksum="EFE0B98F22EE6219" modified="2012-07-11" version="1">MLLKGEKAIDFSLFGSDLKEYKLNEYLGKKVVLVFYPGAFTSVCQKELCTFRDSLANFESLNATILGISMDSPFANKAFKEQNSLSFQLLSDIGGEVSGKYGGVHQDFAGVRGLTVSKRAVFIVNKDGKISYTWVSDDPRVEPDYTEISNHLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V1</accession>
    <name>I2F1V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730068.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0163"/>
    <dbReference type="EnsemblBacteria" id="AFK05904">
        <property type="protein sequence ID" value="AFK05904"/>
        <property type="gene ID" value="Theba_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0163"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056511_2_0_0"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003421">
        <property type="entry name" value="Opine_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02317">
        <property type="entry name" value="Octopine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Octopine_DH" evidence="3">
        <location>
            <begin position="182"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="359" mass="39413" checksum="51EE9C6288C60340" modified="2012-07-11" version="1">MKIAVIGAGNGGQALSAVLAMRGHDVSLYNRSQKRISPLLLERKIRVEGESEGKAKLRYVGTDMKKAIEGAEAIMVVVPAFAHAKIAEKLAECIGEGQIVVLNPGRTGGALEFDKIFREKGVREKAVIAEAQTFVFASRISGPGMVRIFRIKNAVPISVLPSKDNESVFPIISEIMPEFTLAKNVLYTSFNNIGAVFHPGAILMNAGWIETKHGDFQFYLEGISPSVARVLEALDEERCEVTRKLGVEAMGAKEWLDYAYDVKGEDLYAAIHSNEGYRGIMAPISIENRYIMEDVPMSLVPMSCFGRELGVDTRVMDSIISIAGAVMGRDFWKEGRNLVSLGVDEMSVEELTRYVEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X2</accession>
    <name>I2F1X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730089.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0185"/>
    <dbReference type="EnsemblBacteria" id="AFK05925">
        <property type="protein sequence ID" value="AFK05925"/>
        <property type="gene ID" value="Theba_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0185"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_2_0"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="124" mass="14555" checksum="40A73201D8B8E780" modified="2012-07-11" version="1">MWFDIDIRSPLPIYDQIKRGVREEILKERLKEGDTLPSIREMASQIRVNPNTVARAYRELEMEGIIMARQGLGYIVVSNRDQVRDSVFENLSAELREPLLRMKKSGISLERLLEVIEKIWKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X9</accession>
    <name>I2F1X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730096.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0192"/>
    <dbReference type="EnsemblBacteria" id="AFK05932">
        <property type="protein sequence ID" value="AFK05932"/>
        <property type="gene ID" value="Theba_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0192"/>
    <dbReference type="eggNOG" id="COG2250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_1_0"/>
    <dbReference type="OrthoDB" id="2025059at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="135" mass="15107" checksum="DF705C08EF67174F" modified="2012-07-11" version="1">MPDRSQDWLRQAKRDLEHARESAVNGKHEWACFAAQQAAEKAVKALHLSLGQEAWGHMVSKLIQELPEGTDLPAELLDKARILDNSYIPARYPNGHPEGSPFEYFGSKQSKEAIAYAGEIVEFVNNEMAKQKGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F209</accession>
    <name>I2F209_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730124.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0228"/>
    <dbReference type="EnsemblBacteria" id="AFK05962">
        <property type="protein sequence ID" value="AFK05962"/>
        <property type="gene ID" value="Theba_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0228"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399450_0_0_0"/>
    <dbReference type="OrthoDB" id="461923at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M6" evidence="2">
        <location>
            <begin position="140"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="689" mass="77081" checksum="7A6B523795E69D5F" modified="2012-07-11" version="1" precursor="true">MIGRFTLLCMIATVLFSAVLIGAPSFGGVITAYQPDGTRIEFRQYGDEYRNFILDLYGRPLKQDPQSRFWHYGVVVGGEIQRSDLLKGIDQPIGIPSFGPRQLLESLKFSTQSGPEFRDAAVSTEGTIKIPVILIDYPDYPHTYHVKDFEEIIFSSYPELAPFGSMRDYYSEVSNGSVDLSGEVYGWYTADKSKAYYSQNEFELVREAISKADKDIDFSLYDNNDDGVVDMIIVIHEGMGRELSVDQLDIWSFQSRLFDYETNDGVTADLFTIQPERVDWPRENGGDPVKGIATIGVMAHETGHLFGLPDLYDYSEATWGIGYWGMMAYGCWNYVDRPGDMPAHFSAWSKAKLGWFEPLEISRLSGDFFLEDVKIGGRLLKFSNIGRPEEYFLIENRTKFGFDYALPGEGLLIYHIDDAVYGNSGERKQVYLVQADGRDDLMDPSSRENRGDDGDPYPGSSNNLSFGSETTPNSNWYDESLSGLELLSISHRDNEIHFDLGSRKTEFVLFDTVISGNGNGILALKLIETETPIASVLLSLELDGVQIDEIIVSERFDETRREIASSADGVQIKLSLISVKSDEFFPGAVVTILSSGNSKASILESAFLTVEYSDGSLMESFIDSKTNPADINNDGLFDGSDHQIFFEKYFTKYGDETWDMLSTLCDFDNDDSVGSGLIDIALFGIYSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F215</accession>
    <name>I2F215_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">Theba_0234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0234"/>
    <dbReference type="EnsemblBacteria" id="AFK05968">
        <property type="protein sequence ID" value="AFK05968"/>
        <property type="gene ID" value="Theba_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0234"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="31922" checksum="98E2FB102D7FA2DC" modified="2012-07-11" version="1">MAKPEENQNGGVFVSVVSMKQLLEAGVHFGHRTRRWNPKMKPYIYGERKGIYIVDLQKTLKLIEEAYDFVRNSAQEGATFLFVGTKRQAQQIVEEEAKRCDSFYVNNRWLGGLLTNFTTIKKRIEALKNFEEMEESGKLSALPKKEQSMINKRLDKLRKNLSGVKEMQKLPDVIFIVDPKQEEIAVAEANKLGIKVIGIADTNCDPDVIDFIIPGNDDAIRAIQLIVHTMADAILEGREGLEAAAIESKKVTTEEEAVKVSSEEDDTSLEDLEDVSDDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F227</accession>
    <name>I2F227_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730140.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0246"/>
    <dbReference type="EnsemblBacteria" id="AFK05980">
        <property type="protein sequence ID" value="AFK05980"/>
        <property type="gene ID" value="Theba_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0246"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758229_0_0_0"/>
    <dbReference type="OrthoDB" id="1394536at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="365" mass="40939" checksum="E8E238F0BB194C43" modified="2012-07-11" version="1" precursor="true">MSRIVTVILLFACIIAVSGMGAITLGQRYPLGIMPSGLLKIKNSSGTYYITLVKGDSELIVFDANFRPVTIFDSMRNDGINDIIYRDGKLYCFGFYSGRLIVVDASVHPSKWKKIDEIPTSSRLITGSFIDGKVGILTNEFEFLLLDISKREIIKRQKLPVIALSIAEDSNFFFVSLFHNYNLLTHSHETEKGLLVFDEWGNLVNEANVGKRPSYILLEGERIFLVSYVDENLKVLSKRDLAEITTVQLGRYPNFPVIHDGKIWIALTGEDQIMTVDLSTYSTKKYDLMGRGPIKVVHSEDKIYVLETVTGTLEVLDSRGNTIEYVELDGYPVDLVFNGTEIAVLLQEDWQTGKNTGALLLLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F238</accession>
    <name>I2F238_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">Theba_0257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0257"/>
    <dbReference type="EnsemblBacteria" id="AFK05991">
        <property type="protein sequence ID" value="AFK05991"/>
        <property type="gene ID" value="Theba_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0257"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="425"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK05991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="543" mass="62100" checksum="5BDDC96581F4A016" modified="2012-07-11" version="1">MFKEKLENSIKKVLEEFDIYDDKIDFKVEIPPEGFGDLSTNAAFILSRILKKSPREIANIICDRLGNEADYSRVEVAGPGFINVDFSITYLSSVLAELIDAPDFWKRKGDTRIQFEFASANPTGPFTVGHGRQAVFGDVLCRVFSCRGYGVHREMYINDAGRQIGLLGRSLWVRYNQYLGVEEELPEDGYQGEYLIDIARGLAGEIGERFKAVWNSEAEAFFKKYALDKMLEDIMGTLKRLRVEFDNVFFESSLIDDGTVDSVIGMLERKELIYESEGARWLKVSNFVEDDDKVLVRSNGSYTYFMTDIAYHYNKHDRGFKKVFDIWGADHMGHIPRMNAAMKALGIEDGFLNVIVHQYVNLKREGEVVKMSTRRGEFTTLDELVEAVGVDSTRYFFAMFDPDTHMLFDIDLARQRSNDNPVFYVQYANARISNVFRTAKEKNVKRSRDSLELLDSQEDRRIIKLLTIFPEILDSVVADYRTNRLTSYLEDLSRAFHGYYNKNIIVDPENPALSGARLALCEAIQNILRSGLELLGVEAPDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F279</accession>
    <name>I2F279_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0301"/>
    <dbReference type="EnsemblBacteria" id="AFK06032">
        <property type="protein sequence ID" value="AFK06032"/>
        <property type="gene ID" value="Theba_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0301"/>
    <dbReference type="eggNOG" id="ENOG5032DWN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648804_0_0_0"/>
    <dbReference type="OrthoDB" id="1476577at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043748">
        <property type="entry name" value="DUF5693"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18949">
        <property type="entry name" value="DUF5693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="463" mass="51906" checksum="3F2BF8396143DF8C" modified="2012-07-11" version="1">MSLLYIPWRVSLDSNYNRAALVTEKKVDGVPSKQLIYVDNLTEISELGSAVVFMDLRDDWNRLEEILDLQVPVILTGVSPYPVSELASILDSHCAYTGYMEFDERGQYVLDVLKARDNKSLVFRVHNLKKKEYPNYDIDRAVTRYIRSVRERSVDALLFLTPPVDFDYDELVHKSYEELNEQDLISDEITSPRTGSSRFKLLSALFIFVLILSVSPLGAVGITVVFLLFPTIGLPLAAIAGEFAIYRRLSSLDTGVFRGLLLFFSLSVFLGISINASMVGVEFQNGLELFRGVKVSLVALPGWLFVTGFMKSVSRKISKGDLLVFVFAGIAAGYYILRSGNFSFVLDSERMVRDYLDNLLLVRPRFKELLAYPLLAILIHFSFNIKGKLAPVIASGGSLVIVSIVNTFCHATVPLWTGLLRSLYGLLFGTVVSMILITFVKKYSRSCKDVEVLLNESDEDESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F286</accession>
    <name>I2F286_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730182.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0309"/>
    <dbReference type="EnsemblBacteria" id="AFK06039">
        <property type="protein sequence ID" value="AFK06039"/>
        <property type="gene ID" value="Theba_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0309"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_0"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="27868" checksum="8E51571DEE27C6EB" modified="2012-07-11" version="1">MTLLEAKNLHVVLAEDDVKILKGLSLTIGNGELHVIMGPNGSGKSTLANVLMGNPKYRVTGGTVKFMNKNISRLTVDERARMGMFMTFQHPQEIPGIRLRSFLMSVSQSTGSRVPLLKMSKEIDELSLELGLESELIDRYLNVGFSGGEKKKAEIVQMNFMKPRFSILDEIDSGLDVDAMKSIALSINRFRNPENSVLLITHYQRLLEYVEPDRVHILIDGLIAMSGGKELVREVEENGYEAIFDSLKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F291</accession>
    <name>I2F291_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730187.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0314"/>
    <dbReference type="EnsemblBacteria" id="AFK06044">
        <property type="protein sequence ID" value="AFK06044"/>
        <property type="gene ID" value="Theba_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0314"/>
    <dbReference type="HOGENOM" id="CLU_2451150_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="89" mass="10430" checksum="9D54E1932726442E" modified="2012-07-11" version="1">MNNVDELLERFFNALENDTSDLTDEDKISSILSSEFNQKERETLTGVLDSLFGEVTKMVENPKEYFFSNEQEKLDEYLKEKNKKVDNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D7</accession>
    <name>I2F2D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of uncharacterized ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0361"/>
    <dbReference type="EnsemblBacteria" id="AFK06090">
        <property type="protein sequence ID" value="AFK06090"/>
        <property type="gene ID" value="Theba_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0361"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="271"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="530" mass="59025" checksum="4EB587F6E1BD0D25" modified="2012-07-11" version="1" precursor="true">MDLNYVENLDLSGIAVAMKGIVKQFPSVLANDHVNFEVRKGEIHALVGENGAGKTTLMNQLYGLYTPDEGEVFINGRKTIINGPKDAIDMGIGMVHQHFMLVDNQTVAENVVLGSEPRRGPLKLFMDSGRARKIVIELSKKYGLAVDVDAYIEDIPVGMQQRVEILKILYRGAEILIFDEPTAVLTPQETEELFKILLVLKENGKTIVFITHKLNEVMAITDRVTVMRLGKVTGQVNTKDTNPRQLANMMVGREVLLRVEKEEKKAGETVLEIKDLHVKDNRNLDTVNGVSFVVRRGEIVGIAGVAGNGQTELVEAITGLRKVEKGRIFLNGEDLTNHTALEIREAGMTHIPEDRHKRGMIMQYPVYYNLILGKQDEEPFSQEGFINLKAVKTFASDVVETFDIRPKNINMIAGNLSGGNQQKVVVGREISIVPIEPKVVVVSQPTRGLDIGAIEFIHKTLISMRDKGIALLLISMELDEIFSLSDRILVFYEGQIMGEVAPHEVNREEIGLMMAGHKKTEVVRERSDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F5</accession>
    <name>I2F2F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491969.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0380"/>
    <dbReference type="EnsemblBacteria" id="AFK06108">
        <property type="protein sequence ID" value="AFK06108"/>
        <property type="gene ID" value="Theba_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0380"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_0"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="47565" checksum="1642549752BF8FB0" modified="2012-07-11" version="1">MLYAVLAAVAVIAFLFMILFRHENQKNKRLEAAKRRFADLVEVPRSAEFIFIYKKVQQLISSMKEEIALLDTRIENLVMIFDNLSDAFLIASEDGKIEYANKAAQELSSKQLVGLRISEGIDSYYIGDLFEDSVRTQESQESEITIYYPRRSVRNCKIMRVTLKSEVRYLILLRDITKEKEVEAMRRDFVANVSHELRTPLTSIHGYAETLAEDDLEDKETVYRFLSIIENESARMTRLINDLLDLEKLESGEASFSKEDVELGEVVNYVMRIVEPLASEKNVSINVDVDEGIFVEGDFDRLVQLLLNLVDNAVKYTFAKEHGPKEIWLRAYAQNNSAMIEVEDTGVGIPEDSLKHIFERFYRVDKARSRKMGGTGLGLAITRFIVEKHGGTISLESEYGTGTILKVKLPLKKVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G9</accession>
    <name>I2F2G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ORF">Theba_0394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730241.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0394"/>
    <dbReference type="EnsemblBacteria" id="AFK06122">
        <property type="protein sequence ID" value="AFK06122"/>
        <property type="gene ID" value="Theba_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0394"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_2_0_0"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="208"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="289" mass="32358" checksum="E3F6E8C98F7D9936" modified="2012-07-11" version="1">MVSNSSRLSSVKLRCPAKINLYLAVGKSRSDGFHEISTVFQTIDFYDDLFVKHDTRKLYFKCNTSLRWDKENTLYKVIEQIESEIDRRIEIGLELKKRIPSGAGLGGGSSDAAALLKYLAGLFKIDEERVLRIASNVGSDVPFFLKGGTAIASGRGEILSFPGDVSGYSVELSFPGIEVSTPLAYEFIDEDNPELHLDCEMAEKYYLALKSHDIEAVRRMSYNTFEKSIFDRFPMIRDCHSMLSNKNGGAIKTMMTGSGSAIFSLFEGCKGRYSFVTSEELNEKWCSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H5</accession>
    <name>I2F2H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730247.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0400"/>
    <dbReference type="EnsemblBacteria" id="AFK06128">
        <property type="protein sequence ID" value="AFK06128"/>
        <property type="gene ID" value="Theba_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0400"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705575_0_0_0"/>
    <dbReference type="OrthoDB" id="1585380at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="227"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="436" mass="49563" checksum="69A7B1C59434D40C" modified="2012-07-11" version="1">MSKLDGGLFKPGYHYIVGGVVLGTGLIYSFIEGFSLDRVVLIALLSLAALASVYFALVRQLERLVRLVQTGERKSIGELEGQFNQIYGFYRSLSFQIEEERNYYERLYRDYSELLNTLEISVASVDENGNFDLVNDAFTKSFSYGSQQGRYLRIDRFARRTGLIFPLQEGQYEVYSKKLGKRYLVSVVHKQKSGYLLTLTDMTSQWKTKQLLEKTRRYAVDAQTVADLAHGLKQPLANVRLALDLYRRTGKPEYIDTLEKELNAFQGRVGGILQIFRYGEEFDVVDLSEQVMKVATFMSSIFQERKIDFRIISLEKGLVLAQRGRLENVIKNLFMNAVEAGLPSETSIIAKVRASKEYLTLIVADTGKGIDPTNLQKVFKPFFSTKTEGSGLGLYLVHNFCEENDVRLKMRSVKGKGTVFVLTFRRQLDEAQSPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H6</accession>
    <name>I2F2H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730248.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0401"/>
    <dbReference type="EnsemblBacteria" id="AFK06129">
        <property type="protein sequence ID" value="AFK06129"/>
        <property type="gene ID" value="Theba_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0401"/>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_0_0_0"/>
    <dbReference type="OrthoDB" id="1262717at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="260" mass="28969" checksum="DFF26EFABDE0622E" modified="2012-07-11" version="1">MIAFLTDWGSNSYYVGVTKVVMREINRMVEIIDICHDIRPYSIRHGAYVLQRAIKDLPADAVFLAVVDPGVGTSRKPIMMVLKDGRRLVGPDNGLFTLAAEEYGIHEIRELENREYHRGNSRSFHGRDIFAPVAAHVDAGVEPAKLGSRLMSFEYLKYKKPAREGNVLSGEVAFYDNFGNLETNVPEALANDFEEGEILEIGKGRKPFKATFGNTYYDVNPGNLLAHFDSSGFLEITVNKGSARELLAIEEGEPITIVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I7</accession>
    <name>I2F2I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730256.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0412"/>
    <dbReference type="EnsemblBacteria" id="AFK06140">
        <property type="protein sequence ID" value="AFK06140"/>
        <property type="gene ID" value="Theba_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0412"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064956_1_0_0"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="217" mass="25293" checksum="085C5FEB6119CB09" modified="2012-07-11" version="1">MSNDITYLFDLDGTLSSVSDEDFARRYFQLISLFANGKVDFEKLMVSLKSALEVLFDRRDGIKSNYELFMESFVHFVGDHTVKWYEDFFDEFYENEYEELEKIVSPRENVVEALKKLYGSGRKIIIATNPIFPHKAIRKRLQWVGVDEKLTNYVTTMENSHYVKPSTEYYLEILENNSLDAKYCVMIGNDYKMDGACTSAGIEYVDVSSIQSIWRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J5</accession>
    <name>I2F2J5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730263.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0420"/>
    <dbReference type="EnsemblBacteria" id="AFK06148">
        <property type="protein sequence ID" value="AFK06148"/>
        <property type="gene ID" value="Theba_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0420"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_0"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="236"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="369" mass="40779" checksum="2A4078CCB13646FD" modified="2012-07-11" version="1">MNSRKTFALIDLSAYRQNLVYLSGKASPAKLMVVVKADAYGHGAVELSKVAQESGVDRLAVAFLEEGIKIRQSGISLPILVLNYVEKKEIPTAKEFSLTLSLSSFAQLENIIGLNKQLPDFQLVVDTGMRRLGLEWEESIELYNSAVRKGINITGAYTHFATADEKGSGFVLEQREAFGRFLHGLGQRRNRHFETHISNSAGTIYFDNSDFSYVRAGIATYGLQPSKETDENLKPVLSWVSCVSFVKRIRTGYSVSYGRTFVADRDMLVATIPVGYADGYNRLLSNRGYVIISGKRCKVLGRVCMDQFVVDISHIEKPVSIGDEVVIVGTQEGESISAEEIADLCGTINYEVVCSISSRVPRVYKKGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N6</accession>
    <name>I2F2N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_0463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730303.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0463"/>
    <dbReference type="EnsemblBacteria" id="AFK06189">
        <property type="protein sequence ID" value="AFK06189"/>
        <property type="gene ID" value="Theba_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0463"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="599" mass="65346" checksum="8E742FD56A662A40" modified="2012-07-11" version="1">MPAVENTVLICAGGACISAGEKSVKGIFEETLRKYSLDNVVRVVETGCMGACDLGPMLVIYPEGVFYQKITPENASRIVEEHILKGRVVEDLLYRGDAGDLRERPQEELPFFTEQVRIATRNLGVIDPLSIDEYIARDGYFALHKVLFEIGIDDVIEILRKSELKGRGGAGFPTWMKWDFTKKAEGDTKYVICNADEGDPGAFMDRAVLEGDPHSIVEAMTIAARVVGAQKGFVYVRAEYPLAIERLTHAMKMAREYGFLGENILGTDFSFDLEIRIGAGAFVCGEETALINSIEGKRGIPRVKPPFPANKGLWQKPTLLNNVETFANIPPIINNGGEWFSQFGVEGSRGTKVFALAGNVKNTGLVEVPMGITLRKLIFEIGGGVPGGKKLKAIQTGGPSGGCIPLELIDTPITYDNMKKLGTIIGSGGMIVMDEDSCMVDVAKYFLEFTVEESCGQCTPCRDGTRRMLEILERITSGEGTMEDLQLLKDLGENIMATSLCGLGQTAPQPVISTMRYFWNEYEAHVKDGRCPAKKCKSLTRVVIDKEKCVGCTACSRVCPVEAISGSVRKPHEIDPEICTRCGSCLAVCRFGAISKVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P1</accession>
    <name>I2F2P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492079.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0468"/>
    <dbReference type="EnsemblBacteria" id="AFK06194">
        <property type="protein sequence ID" value="AFK06194"/>
        <property type="gene ID" value="Theba_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0468"/>
    <dbReference type="eggNOG" id="ENOG502ZWT0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2508857_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="85" mass="9543" checksum="11933B9AE75E716C" modified="2012-07-11" version="1">MKSELLRVLEGFSVEEVFYTSGEPIPTFVIVSMESEDLLKKIGEMEEIEADIIVISPEEKKELKNASSELSRVVLNVIESGEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q2</accession>
    <name>I2F2Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:ferredoxin oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730318.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0479"/>
    <dbReference type="EnsemblBacteria" id="AFK06205">
        <property type="protein sequence ID" value="AFK06205"/>
        <property type="gene ID" value="Theba_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0479"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_0_1_0"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="276"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="384" mass="42338" checksum="7F8215199AC36B44" modified="2012-07-11" version="1">MREFVLLQGDEACALGAIKAGCRFFAGYPITPATEIAETMARELPKVGGTFIQMEDEIGSAAAIIGASLAGEKSMTATSGPGFSLMQEAIGYAAMTEAPTVIVNVQRGGPSTGMPTKPAQGDIMQARWGTHGDHQIIAIYPSNVEEVYKYIITAFNYAELYRTPVIFLMDEILGHMRESVYLPYDSEIMEVQRVGEAEIAEEDIFHPFEGDDQMMATPLVRMGKSRFHVSGLVHDESGFPVGSPSDSERLLRRLDNKIRLHSDEIVIYDEYMTEDAEILVLAYGSVARSAIKAVKMAREDKINVGLFKPVTIWPFPSTRLRQLLKKVSAVIVAEMNLGQILYEVSRLNKRGAKIEHVSKVSGELITPQEVLDAISKVKSEIMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V9</accession>
    <name>I2F2V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492168.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0539"/>
    <dbReference type="EnsemblBacteria" id="AFK06262">
        <property type="protein sequence ID" value="AFK06262"/>
        <property type="gene ID" value="Theba_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0539"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011262_0_0_0"/>
    <dbReference type="OrthoDB" id="386044at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="924" mass="106043" checksum="543DC9549F428958" modified="2012-07-11" version="1" precursor="true">MSVKKHVIDFETIVYLFLTLFIPLFVTKGFTHEPSTGKHLFYVIGFTIIFLSVLIRKKEISVEFGDVHLVFFGIGIAALLSLIVVSMDNPQYLRYSLEIALYVVFLSFTAVYISNKWNTIEKLEIVMIFFVIGAAVVAFDALLNFYLGVDIFLGKVGEPFARASARSTIGNPNFVSDYMGMTIPMIFYFLISRKPLGFLLKRHFGQLVFKITLLIFLIPMVSSVFVSQTRTVITAIFVGNLLFLVLYFFLKKRKKKEALEDSESRKLGRVSLVFFVLALIIIAVLSYLYLTPSPLSGDGRINITARLEYAITSSGSWNERFSAWYNSIFQWLESENKLRIPFGSGIGTFQLYHLLYSPDVLQHSPYFMPVWNNFKRTHNDYVQGLGEMGLIGFLFIVLLVGLLVFRYLKNLLKIDNRRDLLLYGSLGAGIFSLAVHSFFEFPLHMQPNLMLAIFLGSVVVGKYFNPDLKNKKISRLPFAVVIMVLAGVLIFLKTSAFIGEGFFRIGQTNQQYYLAYYNQAQSLNIKALEQAKNEINSYAGNYAYLKDVTSYMSAKGSEIRSKYPGASQIDLLELAEKDRQSEVRKLLDEIDNRINQYNFYLARSGEYYEKAIENFKFSNRVYPVFGKPLWYIAGLGTKTQRLETAKDNPELMKSILTGKDEYSSDIIPEFKGNPKIIPVHRTTIRTLPFRDFFEKNISVFDNPEYVSGLQLYFITQIQMILDAADYYESSVILFSERQTPRILGRLYTSINSELKKYYSFISSRETMMTSAFGESGEFRQLLIDLVYESADRAIYWFDLAISLLPGTWNRYPDWEDIYIEYMNSIPSVLDSNEERKLKILEVAEKHVWACENMGPEAPVETLQFAIQWGKSNLSNGELIDFEQSLKKIYEEVVSLNTDLLEKSPNIPQDTAERIRTLISLYEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W6</accession>
    <name>I2F2W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N6-adenine-specific methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492175.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0546"/>
    <dbReference type="REBASE" id="48537">
        <property type="entry name" value="M.Mpr42ORF546P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06269">
        <property type="protein sequence ID" value="AFK06269"/>
        <property type="gene ID" value="Theba_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0546"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_0"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="20336" checksum="C3054F044E2DDEE4" modified="2012-07-11" version="1">MLTITGGKFARRMINPTTAKKTRHTPQLARKALFDVIDINSKSLLDLFSGSGIISFEAISRGAANVLAVEISRRACNSILGNKRGIDPSMDLEILCSDFRRAIPSFVKSGIAFDVVFADPPFDEEYIQPLMAVLERNTELLNLAGMLIVESSVREKGFVLQGAGSFDLVDQRNYAGVVFSFMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z1</accession>
    <name>I2F2Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein radc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0575"/>
    <dbReference type="EnsemblBacteria" id="AFK06294">
        <property type="protein sequence ID" value="AFK06294"/>
        <property type="gene ID" value="Theba_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0575"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="97"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="226" mass="24667" checksum="16D6406881B10157" modified="2012-07-11" version="1">MEGQIMPREKLLDKGAGALSNSELIAILLRTGIKGKDVLQLSEELLGYYGSLTALLSAEVNELLNTKGLGKAKAVCLKAALELGQRIFREMTEKTKVRLDEPEGVYHLCHDMAFMDRETVRVISLDSKLNYRGLNTVSVGLLDSSLLHPREVYKPAISRMAAAIILVHNHPSGDPSPSKEDEGVTSKIREAGETLGIKMLDHVIIGSGTFYSFAAGRTFKAEVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F303</accession>
    <name>I2F303_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730394.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0587"/>
    <dbReference type="EnsemblBacteria" id="AFK06306">
        <property type="protein sequence ID" value="AFK06306"/>
        <property type="gene ID" value="Theba_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0587"/>
    <dbReference type="eggNOG" id="COG2362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086038_1_0_0"/>
    <dbReference type="OrthoDB" id="1439650at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="28899" checksum="2417A6BA5E94D8AF" modified="2012-07-11" version="1">MKVFISADIEGTAGIADWNEAKKGNQDYEYFKKQMTAEVKAAVQGALEAGASEITVRDAHGSARNIDPSLLPEGVRVLRGWARDPFMMMQGIDSSFGAVVFTGYHSPSGKARNPLSHTMTGDIYYLKINNKLISEFELNAMSASYHGVPVVFISGDEGIVQIAKQNVPGIQTVSTNIGSGASVDSIHPAKAVKLIEEGVYNAVKNIGVQPVSIPAEFEVEIAYIEHTLAHKLSFFPGVTKKDDRVLTFRDQDYYEVLRKLLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F309</accession>
    <name>I2F309_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492231.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0593"/>
    <dbReference type="EnsemblBacteria" id="AFK06312">
        <property type="protein sequence ID" value="AFK06312"/>
        <property type="gene ID" value="Theba_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0593"/>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046973_1_0_0"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="421" mass="47642" checksum="3A81193D37E7F97C" modified="2012-07-11" version="1">MKIGVVGFGAASIGFISEILDEDHEIHVLERSKDIFSSSISGIRSDGKIFVSETMGGDMEIPLAIQNEVVDFYLEKLNPDDRREVKRGVSFDRRSRFFDLFYSKGFEPVNSTFWHIGTDKLSSVLTKIFEEFSTRNNLKFHFGSRVDDIDIEDEKIILRGEGFEAVFDYVVVAVGRSGHSLIKKVTDRYPEIVASSNTVDIGVRFEIPDHVVEEINEEMYEFKVRLKTKTGYTVRTFCNNPSGKVVLENYDDFVTVNGHSNSGGSSENTNFAILCTTRFTEPFRDPIGYGSYISRLSNILAGGRKVILQTYEDFIQTKRTKRLGRVKPTLPEGDYILGDINLVLPRRISVSITEFVEKLSEVIPGISYPDNLMYAVEVKFYSNKINNSRYKNLKFIGDCSGHTRSITYATGHGRLTGYSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F337</accession>
    <name>I2F337_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0622"/>
    <dbReference type="EnsemblBacteria" id="AFK06340">
        <property type="protein sequence ID" value="AFK06340"/>
        <property type="gene ID" value="Theba_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0622"/>
    <dbReference type="HOGENOM" id="CLU_2826127_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="66" mass="7857" checksum="2E0E628EAF14685F" modified="2012-07-11" version="1">MAKREWQIRSERLGLEAQLRERNKELKLLYDFSRLVDKAEKSIDDILMGLLRILSDAFQNLRARVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F365</accession>
    <name>I2F365_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492310.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0651"/>
    <dbReference type="EnsemblBacteria" id="AFK06368">
        <property type="protein sequence ID" value="AFK06368"/>
        <property type="gene ID" value="Theba_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0651"/>
    <dbReference type="HOGENOM" id="CLU_204730_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="70" mass="7908" checksum="BFDA56BEF310D820" modified="2012-07-11" version="1" precursor="true">MEFVSNAFFILAMGALFLSLIFFEIGTKKVRKPKSEVKPEDYKPYDRKGWYSLLAAGGFLGLSLLFALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F368</accession>
    <name>I2F368_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730446.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0654"/>
    <dbReference type="EnsemblBacteria" id="AFK06371">
        <property type="protein sequence ID" value="AFK06371"/>
        <property type="gene ID" value="Theba_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0654"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672030_0_0_0"/>
    <dbReference type="OrthoDB" id="1251692at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="376" mass="43482" checksum="AF0A56636E0C6319" modified="2012-07-11" version="1">MFQGYVKLLELATNLFTMYRWNNTPTLLRTNEAENAFISAQYCLLMSEMAILKGFEIDQKELFQRLVLKELPKCLLSDISVDTKVLIKSLSPDKWNDVFEKTVEEIIEYLPDERHDAFYLSMVHSKDNSVEGKIIQTGDLLSAKLEAGLHARSFPEFFERPLKDLEARIKDFEEFDPYRLITGNNWLSRYTNALMVLLRAIRWNRLNRNVPTTVAAHSFYVTIIAYILSCIEEEQGNSVNPVESVKRALLHDIPESMTGDIITPTKKKVPGFEEVIAQVEEQMVTENLLDGMPDELIKELKFRMLDPFESVEGKIVWAADQFAATVECLMEIRSGNTQYAFRDAMNRMLDDLSRSDLQSVQFLTKSFRWSLDWTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F399</accession>
    <name>I2F399_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">Theba_0685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492353.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0685"/>
    <dbReference type="EnsemblBacteria" id="AFK06402">
        <property type="protein sequence ID" value="AFK06402"/>
        <property type="gene ID" value="Theba_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0685"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_2_0"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="66" mass="7957" checksum="98300D70DFD5A23E" modified="2012-07-11" version="1">MKAVELQKFTDEELTQMLEDSKRKLMDLRFQLEMNRLKNHSQITSVKRDIARIKTILRGRELGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A6</accession>
    <name>I2F3A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">Theba_0692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730471.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0692"/>
    <dbReference type="EnsemblBacteria" id="AFK06409">
        <property type="protein sequence ID" value="AFK06409"/>
        <property type="gene ID" value="Theba_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0692"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_0"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="184" mass="20437" checksum="283C8C1808E23D64" modified="2012-07-11" version="1">MSRLLKHSIKIPAGVSCKIEGSVISVKGPKGELKQELLPLVKIEADEKEIWVKSNEEVVIRKSDYKRLAKYAGTFWSLINNMIVGVTQGFVKELEIVGVGYRAQLQGKKLVMNLGYAHPVEIEPPAGVEFEVPAPQAIVVKGIDKYQVGQVAANIKRWRIPIVYSGKGIRYKGEQVRTKVGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G7</accession>
    <name>I2F3G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730524.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0755"/>
    <dbReference type="EnsemblBacteria" id="AFK06470">
        <property type="protein sequence ID" value="AFK06470"/>
        <property type="gene ID" value="Theba_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0755"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="46631" checksum="791957512247494A" modified="2012-07-11" version="1" precursor="true">MKRIITVFALLVFSLTGLGAVTLTFWHSMSDYQKPIIDKLVADFNRSHDGIEVKAIFQGSYDETVTKLKAALLAGKGPDIAQVNIEHIQIFSKDGSLQDLTDLISNDPTLSAEDFVESFWQTIIRDGKPYALPFNISALMLFYNKDHFEAAGLDPNKPPKNWEELEEYARKLTIRKSSDSRPSQYGLLWGVDTMFYQFEPLVWQNGGEIFNEDMTECIINSAEGIEALETWRRWFAEGLSPADLTIDEGIQSFTMGRISMGPMTSGGIRYALENIPWDLGVAPLPEGKQKATTLGGGSLSIMSGLSEEKVKAAWTFIKWMVSEKNTLFWYEGTGYMPVLKSAMDSLEIQLIWQRFPQLKAPIESVVFARPRPVHTNIIEIRNILYNAVEQVRKGVSEPKPAFDEAVIKVNELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H2</accession>
    <name>I2F3H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730529.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0761"/>
    <dbReference type="EnsemblBacteria" id="AFK06475">
        <property type="protein sequence ID" value="AFK06475"/>
        <property type="gene ID" value="Theba_0761"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0761"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058393_1_0_0"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="357" mass="39251" checksum="BBC3F3EBF47DAA83" modified="2012-07-11" version="1">MGNGSQTKRVAILSSPEYKKCREKISEGLDLIGFDETLRGKKVLLKVNLLSARSPESCVTTNPLFVRAVAELFLGRGAEVSVGDSPASVSTSVAGYASGISQVCKELGIPLLDFDDPVQIVFDEGTYRSFLISKPVLETDLLINLPKLKTHALTRVTLGVKNLFGCVPGAKKQGWHFRVRNMKEFSKMLLDLAVHLKADLTVIDGINGMDGNGPSNGRIIKPGIIGMSRDVFALDDAIAELFGVNHSKVPILQIARDRGLVGDYDIVGDEVHPEKLLLPETNFIGVYGAAIPRRIVTKFPKIDRERCRSCRVCENACPAKAIDINRFAIDYNKCITCYVCHELCPEDAIVFTRRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K0</accession>
    <name>I2F3K0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ORF">Theba_0789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730556.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0789"/>
    <dbReference type="EnsemblBacteria" id="AFK06503">
        <property type="protein sequence ID" value="AFK06503"/>
        <property type="gene ID" value="Theba_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0789"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_0"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="37687" checksum="32E5C24CA99CC366" modified="2012-07-11" version="1">MKVSDYDFELPEELIAQKPAIPRDSSRLLVIDRETYSFEHRVFAEIEDFLHPGDVLVLNNSRVIPARLLGKKETGAKVEAVLTEKLGGGLWKAIVRPGSKIKPGNVLLFNKISCKVIEHCDDSSRILDFGSVTDEDVKKAGLLAIPPYVKYYPDNPESYQTVYSRPEGSVAAPTAGLHFTDTLLERLRKKDVDVQFITLHVGIGTFRPVKSETVDGHKMHNEFFSVSSEVAERLERARTEKRRIVAVGTTTVRTLESIVARHGCIVGDSGHTDIFIYPPYTFKATDSLITNFHLPRSTLLMLVSAFAGRELILSAYREAILKRYRFFSFGDACLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P6</accession>
    <name>I2F3P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730590.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0835"/>
    <dbReference type="EnsemblBacteria" id="AFK06549">
        <property type="protein sequence ID" value="AFK06549"/>
        <property type="gene ID" value="Theba_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0835"/>
    <dbReference type="eggNOG" id="ENOG502ZM3Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330639_0_0_0"/>
    <dbReference type="OrthoDB" id="2202332at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="206" mass="23482" checksum="E247CCBC3E598B4E" modified="2012-07-11" version="1" precursor="true">MGILNSGKNGKKYSSRNRALFTVFFVVLLIAFVSYYAFGYKIEVVVPSEEVNLSDLTFNDDVFSLLGEAPFPPDQGLANGVSVDREDGESIRVFYPPEDNSVVCLQFELNSRNINVYIWKTFSVDSARSVWDTLFLVEASVLTRDLGRIKKPDYYYAKIVRFGGRDQTLIWQKGKWVVLVKSPGFTLEEDEERLILTELFDSSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U6</accession>
    <name>I2F3U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492592.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0889"/>
    <dbReference type="EnsemblBacteria" id="AFK06599">
        <property type="protein sequence ID" value="AFK06599"/>
        <property type="gene ID" value="Theba_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0889"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_0"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="140"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="39844" checksum="62E15783EAA53E5C" modified="2012-07-11" version="1">MSRIEQFREKLKERNLDGFVLYNMESSNRSSSWYLSGFSGSFSVLIITPKSEYIVTDSRYFTQVEMESKFKLIPYKNGDELKDIIKAALLDDGANHVGFEEETISFGLYKRVFSHLGVELEPADSILKDMRMVKTADEVEKIKAAVKVAEDALTETLNFIRPGRTEEEICATLEYEIRKRGGYLAFETIVGSGPRSAIVHGRPSKRKLQTGEFLLIDYGARVDGYNSDITRTYSIGNATDEMIKVYETVLKAQTEAKRAAKAGVIGSYLHELAASIIEEAGYGDYFGHGLGHSLGMDTHDGQGLSPKNSAPIPAGAVITVEPGIYLPGKFGVRIEDDCYFRENGIDVLTNLDRELKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W1</accession>
    <name>I2F3W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492610.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06614">
        <property type="protein sequence ID" value="AFK06614"/>
        <property type="gene ID" value="Theba_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0904"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167992_0_0_0"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="110" mass="12758" checksum="639CE281355C5D3B" modified="2012-07-11" version="1">MLYIEVPLKESPVQLSKDTEYILLEPVEQKPVAWGAFENKMGLVLAEREWNDSFRVWDILVWEKYQRRGLGSKLMGTARNYTTNAIVRRLVVETQSSNYPAISLSLNYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W9</accession>
    <name>I2F3W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730646.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0914"/>
    <dbReference type="EnsemblBacteria" id="AFK06622">
        <property type="protein sequence ID" value="AFK06622"/>
        <property type="gene ID" value="Theba_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0914"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428841_0_0_0"/>
    <dbReference type="OrthoDB" id="271104at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="107"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="638" mass="72000" checksum="FF4507BA7AD91098" modified="2012-07-11" version="1" precursor="true">MKRIGFLFLLFSLFLITTVYSKTLELKSWQIWDFSYNGIHGVCCAVSVKNGEIPVTGLSFEDFTITETLVDEYGNVLSKAEIAPEQREDQFGGIGFWERSVSSSKIDLVFLIDKTGSMADQIESIKSELKEFVNRLEADACDFRVAVLLFEAALLEEPGRKPPDHPFYGAMEMDELLLAIEEIETAGEWHINTWSYDAILFSSQLEFREDSRAVLVVITDTLPETVHGPFWYFSGGSVATKRAVEIALEERGIELEYFQPEESELAHMENYNRLINPALSESNFDHLAGAVSLGWPFKQDLIKVDALPVSESIYYLSWNSGLDEITDYYRKEGFKVEVDVKCGDEHVSLSYSPFFDEEGYLQSSEDYHLPVLDEEGNQLPDKAVEMGLLRELGDLKAFSGNYATKDGVLQLRSVDPGDYLYRLYAYGRSSYSYSTLRLKGTGKISFVQGEVIPDFVVARTGDAFLESVKIRGLMDEFVSNKIAVNESKEFAEKSLKWIDAVASDGLNLREMEALKRVYVSVGAFLNGMAYAAIESERVESDLLQMVRDTRSMTRKAGHRLQGMGSREENRQSIQVSMQLRKLSRHDFLKLPHFVIPNSFRDPGLILSEDGGPLTDNVAFSSDQRVFVLKRAAALRRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z4</accession>
    <name>I2F3Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative selenium metabolism hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0941"/>
    <dbReference type="EnsemblBacteria" id="AFK06647">
        <property type="protein sequence ID" value="AFK06647"/>
        <property type="gene ID" value="Theba_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0941"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017706">
        <property type="entry name" value="Peptidase_M20/DapE_YgeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03526">
        <property type="entry name" value="selenium_YgeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="178"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="396" mass="44208" checksum="B6C6F026764F4983" modified="2012-07-11" version="1">MSRDLLTKAESYREELTEFLRDLVSIKSFSAGEREVVQRIQKEMEKVGFDEVRIDGLGNILGRIGSGKNVIAMDAHIDTVEVGNEKLWKVDPFGGVVSDGVIYGRGASDQKAGMAAMVYGARIMKEEGLLGDFTLYVTGTVMEEDCDGLCWRYIIKEDGIIPDYVVITEPTNLNIYRGHRGRMELQIRTSGLSCHASAPERGINAIYRMSRIIQQIEVLNERLKDDPFLGKGTIAVTQIFFKSPSQNAVADECTIQIDRRLTAGETKETVIEELKDAIRISGEEAEILELFYERPSYTGLVYPVEKYFPTWVMDESSEIVQKTVNTYKEVFGEEPFVDKWTFSTNGIATAGVFAIPTVGFGPANEIFAHSPDDQCPVDHLVKAAAMYALLPLRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F404</accession>
    <name>I2F404_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730678.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0951"/>
    <dbReference type="EnsemblBacteria" id="AFK06657">
        <property type="protein sequence ID" value="AFK06657"/>
        <property type="gene ID" value="Theba_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0951"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_6_0_0"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="16759" checksum="7604E3901EB619BD" modified="2012-07-11" version="1">MSISYNHVVLIGRLTRDPEIKFAASGTQITTFTLAVDRNIPSSNNDNTDFIRIVTFGKTAEFVGNYITKGRLILVEGSLRINKWKTQDGEPRSNAEVAASNIRFMETKAQAQQSSGGFDRPSQDTGVIEATGNDDITFFGSETEDSGSDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F423</accession>
    <name>I2F423_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730696.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0970"/>
    <dbReference type="EnsemblBacteria" id="AFK06676">
        <property type="protein sequence ID" value="AFK06676"/>
        <property type="gene ID" value="Theba_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0970"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="277" mass="31296" checksum="8387389EFF84880A" modified="2012-07-11" version="1" precursor="true">MRKSRREIVLKTVIAWIIALIWILPLMGVVMTAIRPFSEVLDGWWSLKPFTATLSNFTGALNHRTAPLYRGMINSLLIALPSTVIPLMLATLAGFGISRYGFPFRKTFILTVVLTLALPQQMIAIPIFKIMSTLGLVDTYFGLILLHTAWGIPWITFFMRNYFKTLPTDMEEAARIDGAGDLGIFFRIVLPNAFPAIASSSALQFTWVWSDFFLALILIYSPDKLLATQRIPLMRGVYHVDWGLLSAASLMVMIVPILIYVLLQRYYVKGMVGWTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F470</accession>
    <name>I2F470_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC-type transport system, periplasmic component/surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1018"/>
    <dbReference type="EnsemblBacteria" id="AFK06723">
        <property type="protein sequence ID" value="AFK06723"/>
        <property type="gene ID" value="Theba_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1018"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_2_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="2">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="350" mass="38842" checksum="5AEEECC51BDEC695" modified="2012-07-11" version="1" precursor="true">MRKIFLFFSMILIAAALLAAPLKVAFIYVAPVGDGGWSTMHNEGRLHLERVFGDQIVTDFIESVPEGAEAEVVFRGYAQRGYDLIFGTSFGYMDSMVKVSQAFPNSTFMHCSGYMTTDNLGTYFGRMYEPRFLSGLIAGAMTKTNIIGYVAAYPIPEVIRGINAFAMGVQYVNPEVKVHVVWSNTWFDPAREKEAAESLLDIGADLITQHQDSPAPQQAAEDRGVFSIGYNSDMSAFAPNAFLAAPVWDWGPFYEYVVRNVMDGTWTNEQYWGGIKEGVVDIFVSDLVPDGVAKLVMTMREAIVQGLFHPFDGPVYDQSGALRYAEGERPTDAELLSMDWFVNNVVGKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F481</accession>
    <name>I2F481_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730743.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1029"/>
    <dbReference type="EnsemblBacteria" id="AFK06734">
        <property type="protein sequence ID" value="AFK06734"/>
        <property type="gene ID" value="Theba_1029"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1029"/>
    <dbReference type="eggNOG" id="COG2143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239653_0_0_0"/>
    <dbReference type="OrthoDB" id="1398962at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="224" mass="25795" checksum="7055500CA8978233" modified="2012-07-11" version="1" precursor="true">MKKVVFLLVLLLPGIIFSYVGMLDDFDTALKLAKIEDKEAIVMFSDTSCVYCVKFVKETLADETVQDLLKAGFVFSQIYKSNPGNASYVVGEEWKEMSYGELYAYFQIRGTPTFWFFTSENALLTNLPGYVPAKDFTTILRFLGERAYETATFEDYRSKESTFMGEPKIVRVSEEDYNYVLQNDPIAREYKDQEVDKFTVWLTKDESTAESLLEEGVFRVILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F483</accession>
    <name>I2F483_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730745.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1031"/>
    <dbReference type="EnsemblBacteria" id="AFK06736">
        <property type="protein sequence ID" value="AFK06736"/>
        <property type="gene ID" value="Theba_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1031"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_0"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="437" mass="48476" checksum="0A9525714FCD0AD5" modified="2012-07-11" version="1">MSISEADWTPLSERLRPKEFDDIVGQEHLTGKKGIIRGAVDSGKLFSMILYGPPGTGKTTIGEIIRSKLGNDYHFEFFSASLQGTADLKKHFAHGERLKRVGQQLVLFVDEIHRLNKSQQDVFLPVTEKGIIILIGATTENPSFEVNPALLSRCRLVILKGLKDSDISALLNKALEKDLILKESGVTVDGEVIEVIAQSSGGDARIALNLLDTLVESAAALDKPVLDLEVMNELSVLPAGRYTKKGEEHYDIVSAFIKSLRGSDPDAALYYMLRMLEGGEDPKFIARRMVIFSSEDIGLSDPMALVIANAAFQAVNNVGLPECILNLSEAAIYLSVATKSNRTYLAMVKAQEKVKTTPNLEIPLKLRNPVTKMMKELGYGKGYNYPHNSGGFSREYYLPEPIKEEVFYVPGNSGKEKFLFERLRSLWKGMKNYPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F0</accession>
    <name>I2F4F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730800.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1098"/>
    <dbReference type="EnsemblBacteria" id="AFK06803">
        <property type="protein sequence ID" value="AFK06803"/>
        <property type="gene ID" value="Theba_1098"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1098"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_2_2_0"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="17640" checksum="58768F0DCC249EDB" modified="2012-07-11" version="1">MEFRKMRRSDKEVPENEAREMLKKGSFGVLSTADMNGMPYGVPVNYVYEDGRIFIHCASSGHKLDNIFQNSHVSFCVVEYAKVIPERFSTNFRSAIAFGKASIVDNDEEKIEALLKLVSKYSSDYVHEAINEINNSLEATSIIRIDVLHLTGKSANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I0</accession>
    <name>I2F4I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730827.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06833">
        <property type="protein sequence ID" value="AFK06833"/>
        <property type="gene ID" value="Theba_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1129"/>
    <dbReference type="eggNOG" id="ENOG502ZDTS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426493_0_0_0"/>
    <dbReference type="OrthoDB" id="1622117at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="190" mass="21918" checksum="B9EF7B773D9CFC89" modified="2012-07-11" version="1">MQKATSAEKRNELDELRNLVGSYSESADDNHVHLNLRGPDLTGDDAERAIDVLEEKTKYLPLKGNLTVMVDCDCGDLLDSSIKIKDSIRKQLIPLLYYVDLDLRRLSRVSVVLMIFGVLAMGTASLLSELSFNAYALHEILVIASWVFIWASVETFFFDRRRLKNKKHRLQRIYFADYVITDCQRENDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J4</accession>
    <name>I2F4J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06847">
        <property type="protein sequence ID" value="AFK06847"/>
        <property type="gene ID" value="Theba_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1145"/>
    <dbReference type="HOGENOM" id="CLU_190474_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="72" mass="8667" checksum="09BA3B043DD55CFA" modified="2012-07-11" version="1">MIDELENIPEDKLQLLLELIRSSKSDLSDLQPKRRSITDYAGSWKEMDSEQYNTMINKLRDRREKARRERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N7</accession>
    <name>I2F4N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730878.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1192"/>
    <dbReference type="EnsemblBacteria" id="AFK06890">
        <property type="protein sequence ID" value="AFK06890"/>
        <property type="gene ID" value="Theba_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1192"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_0_0"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="100" mass="11552" checksum="4C2E64A74619159C" modified="2012-07-11" version="1">MQDLENVIEALRKSLPELKDRFSVSKIGVFGSYVKGNQNDDSDVDIYIEFDRVPGLEFVELAEQLERIVRKKVDLLTPLGLKSIRNARIRQDIEQSIKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V3</accession>
    <name>I2F4V3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_1268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730937.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1268"/>
    <dbReference type="MEROPS" id="M18.004"/>
    <dbReference type="EnsemblBacteria" id="AFK06956">
        <property type="protein sequence ID" value="AFK06956"/>
        <property type="gene ID" value="Theba_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1268"/>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590123_0_0_0"/>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="472" mass="52405" checksum="15B368974C40BD09" modified="2012-07-11" version="1">MKREDAKKLSDKLTMRKRSTWFSLDKEEVFAYSKEYMKFIGKSVTERLAVKNLVDLLESRGFKPVSSFEKTGVKRGDRIYLTKDNKALIATVIGEDLKEGIDMVAAHLDAPRLDLKPSPLVEDSEIAMLKTHYYGGVKKYQWLNIPLAFVGTVIKSNGESVDVSIGLKSEDPVFVISDLLPHLDNREGDFRKVFQGKDLNAMSGTIPIVEGKDFENPVKLMFLNLLYEKYGLVEEDFFSADIQLVPALEPREVGLDRSMIGAYGHDDRVCSYSALTALADMSSIDNPKRTAMVLLFDREEIGSEGVTGAKGQFWVTFIEKLLNLSGAKGLYEIDFLLEKSRMLSGDVAAGFDPTFKDAHDQANVARFGYGIAILKYTGSRGKSGTSEASAEFMGYVRRLLNQKGVHWQSTILGEVDRGGGGTVAKFFAERGVTVVDAGTPVFGMHSPFELLSKADLYETYRAYKVFLEGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y2</accession>
    <name>I2F4Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486670.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1297"/>
    <dbReference type="EnsemblBacteria" id="AFK06985">
        <property type="protein sequence ID" value="AFK06985"/>
        <property type="gene ID" value="Theba_1297"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1297"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_1_0"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13401" checksum="2D199FF5FCBDEB7D" modified="2012-07-11" version="1">MFGKIDKHDGVPAYIQIMNIVKREIMLGRLENGDQLPPVREMAAMFGVNMNTVIRSLERLQFEGLVEAEHGVGYFVKTAHSINREVMKTISETVGELKKNGIDLQMAKVLLEEVWKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y6</accession>
    <name>I2F4Y6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730963.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1301"/>
    <dbReference type="EnsemblBacteria" id="AFK06989">
        <property type="protein sequence ID" value="AFK06989"/>
        <property type="gene ID" value="Theba_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1301"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="240"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="460" mass="51688" checksum="10523B0796EA47B8" modified="2012-07-11" version="1" precursor="true">MKKLLPIRIKLTLWYVLFLGVILFAFSILIYMILSAQLHSETDSSLRIVSSQLLANIEIVQNYPVFKKTVEMDSLTNRLLAEGFAVRLMDNSGSIVEGFGPFGILKASIDLTDKEFSSVSTSVGVWRIFTLQIGQWGWIQVGESLSSVRVALFRLSRLMMLIGPTIIILAVVGGFYLAKKSLEPVERITLLAEEISVEKLNKRLNLTLPDDELGHLASTFDGMLERLEESVKKQRQFTSDAAHELRTPLTAIRSIVDVTLHRDRSSEEYVSALLQIQNEIERLSSVIDDLLIITRLENTLPKREFAVFSVSALIWEVLETMMVLAKEKNIEIETDLQENVEIAGDRKHLSRAVFNLVDNAIKYTPENGKIRIAAKLSESKERIEIIVEDNGIGIQLEDMERIFDRFYRVDRARSQTRGTGLGLSIAKEIVKAHGGVISVKSSPGKGSTFKVSLPSKIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F560</accession>
    <name>I2F560_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731009.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1375"/>
    <dbReference type="EnsemblBacteria" id="AFK07063">
        <property type="protein sequence ID" value="AFK07063"/>
        <property type="gene ID" value="Theba_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1375"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056531_0_0_0"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
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            <end position="71"/>
        </location>
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        <location>
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            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK07063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="31882" checksum="85B21EC534FFC8A6" modified="2012-07-11" version="1">MIPHLSQLIDQAKNNPKTVAIAAAEDSIVLAAAKEAAEHGIASFILFGQKKKIEEINNELSFSEGFTIVHCSTKIESIEKAVKAVSLKDAEILMKGNVKTGELLGIYLKDEFGLKTGRTMNLVTVFEIKRYHKLLLVTDAGMVIAPDLNQKADSIINSVSVARALENKRPKVAVLAAIETVNPKMPATIEAAILSQMARRGQLGSVDVDGPFALDNAISREAAEHKGISSSVAGDADILIMPDIEAGNIFYKAMAFLSECQLASTIVGGKAPIILTSRADSAETKLYSIALNVLLAGVI</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Swithers K.S."/>
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                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
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                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
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    </feature>
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        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AFK07108.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="16458" checksum="029424F980D41435" modified="2012-07-11" version="1" precursor="true">MKEKTSGGLNFQIIEGAFFAVIAVFIIVVSAGMNPYGSWSLAPGLFPLIMGVILLVLAISPIFQAVRSKSFKSGGFDKVDWLRITISMALTFIYVWLLPMIGFIAISIPYLASMLLLLGEKRWWLLGIISVGTTLGLYYAFGVLLSVYLP</sequence>
</entry>
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    <accession>I2F5I5</accession>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Bruce D."/>
                <person name="Detter C."/>
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                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
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                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="27376" checksum="35AFC90E84C046CE" modified="2012-07-11" version="1" precursor="true">MKHCLVLVIVFSLLVGASLLASESVYDDLTLFIQQVVEAGDIDTLVGIHFHLADTESADSGYRDLNLKARIIMVGGEDFYIEFLEPDELSKIALVYLIREEVVFSVVDGDPWKQYKSTYQTDFIAKLIEDFFSGLLDSRNFTWTVSTEEERRIYMIDPSEQRLKVLGLLGGGGYLPNLMHIHVSLLRKEGCFPKIEYVKITDRVGDEYLLIEIEEFKTVVDRSIFTELRSKYYETFQK</sequence>
</entry>
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    <accession>I2F5J3</accession>
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                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
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                <person name="Pitluck S."/>
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                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <dbReference type="EMBL" id="AFK07196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="33" mass="3667" checksum="76244F8DE64BF02A" modified="2012-07-11" version="1">MGPFFLQMRGLDKVTLDSEEKTLISRAGLGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q9</accession>
    <name>I2F5Q9_9BACT</name>
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        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
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                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
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                <person name="Dlutek M."/>
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                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657637" evidence="1">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="45618" checksum="3F120D7E3CFDC493" modified="2012-07-11" version="1" precursor="true">MKKLLLLFLVSAFLVVTALSAEITFWKFTDTYADPTIQRFVDLWNEENPDKKVVFETFPWGDYTGTKLTTAFATGEGPDVFFISPGDFLRYVNTGIALPLSKYLTEDIIADFLPETIEAVTVGGEIYALPLEMEPVAIFYNKAAFEEKGISQPQDWAELKEAAAKLKTADRYGIIVEVAPGYYQNFTWYPFLWTAGGDVVDENWEKSAFESEGAIAALDLWGSFVKEGLAPSSLPAGANDIGMFGNGLADMIVCGFWGVKQLQTQFPEFDFGVFPIPPYEKGGESISVYGGWKMMLNAKGKNTDIAAEFARWLVAEQIDFPLDWCTVTNSKFSPRYSVLEAGNEFYNTPPNDVFLEILKTSKSEPTFTPEMVKAVSDAIQAVMFAGMDPKAAAKGASAAINAYLSRYTGGVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5U0</accession>
    <name>I2F5U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Swithers K.S."/>
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                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07293.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
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    <dbReference type="STRING" id="660470.Theba_1629"/>
    <dbReference type="EnsemblBacteria" id="AFK07293">
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        <property type="gene ID" value="Theba_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1629"/>
    <dbReference type="HOGENOM" id="CLU_920729_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="302" mass="34772" checksum="F4BF5505DC010B60" modified="2012-07-11" version="1">MGREKITEKTPEKSKGKNKEKFKSLTTSFRNRPVETSEESEEELPDEEAFEEVESEDHDNDETSNSDPFASVENLENLVFEPAERNPISEKRVVLEIVKGKRYHCLRRYRWSFEFSENSPQKEEHMRRFGETVRRTGRIIENFLNGYLEGETASIQDLFGSLSSKILFGVSDLNDVSKNQLSWYLFRMPDGVLYTLNCLTPRSGAPNLSKQALSIMRISMGDPEVGEVLKYKFEEVIAKSTGLIDYSLELEDLLGRVICLNRTIMKAGYPESKLGEPRALLKELNRSSIRHYFHQIAGRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X6</accession>
    <name>I2F5X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1667"/>
    <dbReference type="EnsemblBacteria" id="AFK07329">
        <property type="protein sequence ID" value="AFK07329"/>
        <property type="gene ID" value="Theba_1667"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1667"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064060_0_0_0"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="241"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="368" mass="42001" checksum="B726E95E8F70856F" modified="2012-07-11" version="1">MQRVSDDFGKNLSVSASAAMEYESQGEKMLKRVNELMAAREDISELLGMNPLYIMYDNNSNHLQFISNVIKLNDYDLLAKSLPWVYKTYTSRDFSVEFFPEVLKAWMKAIDEFLTPESAAQVIEVYLEMLDSHNAAVEHAQEGLIQMKVDEDWKAIERQTVLALLTGDYKKLREIANREINSEKLLADFYLKVVQPAMYEIGYLWQTGEISIAEEHLATSLMNRLMASTYSMIETVPSHPRRKAVVLSSQNEYHELGARILADLLELSGWNVSYLGANTPVSEVLKHLKKNLPFLLAISVTMSFNLDLTKKLIQSVHNDSDFKTMRIMVGGLVINESEDLWKRLGADGTAESADEAIELAKQWWKERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Y1</accession>
    <name>I2F5Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731229.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07334">
        <property type="protein sequence ID" value="AFK07334"/>
        <property type="gene ID" value="Theba_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1674"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48487" checksum="7E7A819FE1D50819" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWRYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIGRWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERLEECKLELHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTSRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSQLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F606</accession>
    <name>I2F606_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731253.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07359">
        <property type="protein sequence ID" value="AFK07359"/>
        <property type="gene ID" value="Theba_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1700"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48608" checksum="A2448A01B02BC102" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWQYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLKLHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTFRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSQLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F642</accession>
    <name>I2F642_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1661</name>
        <name evidence="3" type="ORF">Theba_1738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731219.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1661"/>
    <dbReference type="EnsemblBacteria" id="AFK07324">
        <property type="protein sequence ID" value="AFK07324"/>
        <property type="gene ID" value="Theba_1661"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07395">
        <property type="protein sequence ID" value="AFK07395"/>
        <property type="gene ID" value="Theba_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1661"/>
    <dbReference type="KEGG" id="mpg:Theba_1738"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336190_0_0_0"/>
    <dbReference type="OrthoDB" id="1602420at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="205" mass="22395" checksum="A0701A0E6CF9DF17" modified="2012-07-11" version="1" precursor="true">MKSFRLTVVLVLTVLFLTACPIKNSKPEWGVIETIVENIGELIQINLANYCSDPDGHLLSYSLIGGPGTVSGSLYEWTVSGPLGDIAVTIKAEDEKEASSDKTFTVTVKSFPNVPSNPSPANDAKDTDLEVLLSWEGGDPDGDAVLYDLYLSTFHNPSLFRSNRTTNTYNKIGLLPNTTYYWKIAAKNEGSEPVVGPIWSFTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F682</accession>
    <name>I2F682_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Entner-Doudoroff aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731269.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1784"/>
    <dbReference type="EnsemblBacteria" id="AFK07435">
        <property type="protein sequence ID" value="AFK07435"/>
        <property type="gene ID" value="Theba_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1784"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_0_0"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="202" mass="21661" checksum="C25B47C70A0F41ED" modified="2012-07-11" version="1">MKNIILQERIMAVIRSDSVERCVEIGRSCFRGGVKILEITFTVPDAPKAIAILSKEIEGAYVGAGTVITDDQFSKAVKSGAKYVVSPHLSEELAIQSRALETLYLPGIMTPTEYVKATALGSSMVKVFPGDVLSPSFVKSLRGPFPEALCVVSGGVNLDNIDTWFKAGTAAVGIGSDLTKGSPEEIEEKARQYVAKVKNFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E2</accession>
    <name>I2F6E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731313.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1845"/>
    <dbReference type="EnsemblBacteria" id="AFK07495">
        <property type="protein sequence ID" value="AFK07495"/>
        <property type="gene ID" value="Theba_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1845"/>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_0"/>
    <dbReference type="OrthoDB" id="890789at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="301" mass="32719" checksum="6D1D66786AC43344" modified="2012-07-11" version="1">MKAIIVHGGTGSFKSVTDADEHRRGIEEAVRQGFLTLEKINSAEEAVVTAVSVMEEDPTFNCGRGSVLTYRGDIEMDAAIMDNNLNAGAVSGLKRILHPITVARAVMEQTDHVLLAGAELEEFVTVLGFPREDNLIVPKRLVQWKEELEKIARGEKTRFGKSVKLAKKAEEYHSTCGAVAIDDHGRMTAGTSTGGMMMKSFGRVGDSPIIGAGTYADSFGAVSATGHGEKIMKLTLSRLVAFFMEQYPAQKSVDIALERARYFDCECGLIALDRYGNIGIGHTSKDMSWAFIKDGHAPVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H2</accession>
    <name>I2F6H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731331.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1875"/>
    <dbReference type="EnsemblBacteria" id="AFK07525">
        <property type="protein sequence ID" value="AFK07525"/>
        <property type="gene ID" value="Theba_1875"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1875"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780343_0_0_0"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="260"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="355" mass="40859" checksum="3969F130A61910D4" modified="2012-07-11" version="1">MNIIPGYVELVEILMACGLADRKSYFDAVSHDLGFDFEPGQELGAFLLKIRENENWSIKVVADVFSEIKDSVIFFCDFPERPGGEILLEDSIESLANNFEEKSRCVVNSILSNNLNFSQEEVDKILEGDLSIVPEAVNKAEDLSENTTWFITQLINFPRQSKEILLFALNEMKKYYEESGLRKKNRDQIAEKLKLFENDQYNQIAEGFLDFYGIKAREDLPLHLLFQNTLKYSGLKFASSCNTQLIVFSEHFKQIEEIMNPSVTDNTLRLFLRNLADQTKMQILKSISEEPKYVDELAKLVGLSKATVSYHLSTLSELALVKSRKDHRRVYFSLNKERLEKILKGLETLYDEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H3</accession>
    <name>I2F6H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial regulatory protein, arsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488286.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1876"/>
    <dbReference type="EnsemblBacteria" id="AFK07526">
        <property type="protein sequence ID" value="AFK07526"/>
        <property type="gene ID" value="Theba_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1876"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780343_0_0_0"/>
    <dbReference type="OrthoDB" id="1060523at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="355" mass="40888" checksum="485973DA20851408" modified="2012-07-11" version="1">MEIITGYFEIYDLTMAIQFSLNTGPVEKVLKTLGVDYEPSSQLLEFRETLLKDEEWSTRMYITFMNELGVMAPILFPIRQKLQDGMQVTIEESLNVTEEGIELIRDRFIQVFADRRLKISHDELNRMISEEPQKVSKAIEAIGGVSPDTVWFVHQLLFFPKTAMDFLSSKTMKILNYYEGSGLRDLNTRLVKGYIESSSSQKIKDAFSNYLDYYDIVLDETKPVYITLQNSVPHTNSGLMTYPTFHLLIMGLEEVTEDFSGRIPQEVRLRSLLKVLSDETRFKILKRLSKEPALQKDLVEFTGLAKSTISYHMGLLFKSSLIDVDPFSSIICVRKETVRRAAADIRNLLNLRDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J0</accession>
    <name>I2F6J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1895"/>
    <dbReference type="EnsemblBacteria" id="AFK07543">
        <property type="protein sequence ID" value="AFK07543"/>
        <property type="gene ID" value="Theba_1895"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1895"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="100" mass="11096" checksum="0D00579E445210A3" modified="2014-02-19" version="1">MSVTKEDVMKALGEVYDLEIGFDVVSLGLIYGVELENENDVKVKMTLTTPMCPLAGLMLEDARRKVSEIEGIGDVKMELTFDPPWSPEMASDDVRKILGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P9</accession>
    <name>I2F6P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1957"/>
    <dbReference type="EnsemblBacteria" id="AFK07602">
        <property type="protein sequence ID" value="AFK07602"/>
        <property type="gene ID" value="Theba_1957"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1957"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="22834" checksum="7B0AF5E6BE5D8E9A" modified="2012-07-11" version="1" precursor="true">MEYLDLSLRLFCALVAGALIGATRERIYKPAGLRTHSLICVGAAFITVLSTTVFVTAEHGDPGRVAAQIVSGIGFLGAGTILKKGFSVKGLTTAATLWVTAAVGMGFGSGEYLLSAVVTVFALLIVLFLKRIELFIGGRNLPRVLIVAENSQETSTKVSEWFKDNGLTVESMEIEEDDEVLSLLIELSRGDALKVKNIMVGLSTLKGVKSAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q4</accession>
    <name>I2F6Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(3-hydroxybutyrate) depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731402.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1964"/>
    <dbReference type="EnsemblBacteria" id="AFK07607">
        <property type="protein sequence ID" value="AFK07607"/>
        <property type="gene ID" value="Theba_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1964"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_4_0_0"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="34312" checksum="F09804032374CABE" modified="2012-07-11" version="1" precursor="true">MLKTMVVIGTLLAMGFYFISGTKKGIDEIVTIEHDGRIRQSIVHLPPMIQDDKLPVVLVFHGLFGNSNYTKNTYGMTEVGDREGFITVYPEGTGTLNSVLLSWNSGFCCGYAMENDVDDVSYIAELLGRLESVYPIDEKRVYLIGLSNGGMLVYRLMSSYPDLFAACAIVSSSPAGGASEDNVVMIEPPDTAIPLIVFHGMEDPIIPFDGGFSSSSEANGIYFPSIEESVKLWAEKMGAVNMSEKSLENGLVLLREYTGEDERSLVHFYAITDGDHTWPGREKGIDALSSSSQANIKASELIWEFMKDKHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q9</accession>
    <name>I2F6Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1969"/>
    <dbReference type="EnsemblBacteria" id="AFK07612">
        <property type="protein sequence ID" value="AFK07612"/>
        <property type="gene ID" value="Theba_1969"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1969"/>
    <dbReference type="HOGENOM" id="CLU_212092_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="54" mass="6344" checksum="2D57C12F36FC0DF9" modified="2012-07-11" version="1" precursor="true">MAILYTIISVCYYLITAFIIFVIARSLVKTKNFQEAILFSVMLMPFILRLLRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W0</accession>
    <name>I2F6W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731446.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07663">
        <property type="protein sequence ID" value="AFK07663"/>
        <property type="gene ID" value="Theba_2020"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2020"/>
    <dbReference type="HOGENOM" id="CLU_2106051_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="115" mass="13278" checksum="02637374283D5C46" modified="2012-07-11" version="1" precursor="true">MGFAVRRSRRPKIGLIRNNFIRASVLLGIVSPVSIYGITRFFGARERLEGFGWLLIMLIAVWILVAVIWVLSLRVYFEARKQIVRSRRGFRTGNLKPTRMILNRSQVSSIRTKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F704</accession>
    <name>I2F704_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="10" type="ORF">Theba_2069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731484.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2069"/>
    <dbReference type="EnsemblBacteria" id="AFK07707">
        <property type="protein sequence ID" value="AFK07707"/>
        <property type="gene ID" value="Theba_2069"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2069"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_0"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="482"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="614" mass="67271" checksum="69D4ECE10F497ED3" modified="2012-07-11" version="1">MANKEYTVGIDLGTTNSVISWVKPDGNVEVIPNAEGNRTTPSIVSFSKTGEIIVGEPAKRQTILNAERTVRSIKRKMGSDFKVRIDDKEYTPQEISAYILKKLKADGEAYLGGKITKAVITCPAYFNDAQRQATKEAGIIAGLEVQRIINEPTAAAVAYGIDKKKGDKKIIVYDLGGGTFDVSVLDIGDGVVEVLSTSGNNHLGGDDFDQRLIDYIAEDFRKKNNVDLRKDKQAFQRLKDAAERAKIELSSKYETEISLPFITATADGPLHLEMKITRSTLESLIKDLVEGTREQIERAMSDAKLSPKEVDEVLLVGGSTRIPMVQSFIKSIFGKDPNKNINPDEAVAIGAALQSGILSGSVESDLVLVDVTPLTLGVEVMGGLMEPIIERNSTVPVKKSKVFTTAADGQTEVEVAVFQGERTMARDNMSLGSFKLTGIAPAPRGVPQIEVTFDIDSDGIVHVSAKDLGTNREQSMVVSGRQKMSEEDIKRIVEEAKKYEEQDKQKKQEVELKNQADQLAYSMEKLLNESGDKISSEDRGKLEGLVKDLRDALSEDNIQRIKLLFDQLQKESMRVGQSVYQKAQAQAPADGGPQEGENHDNDTGTEYIPPEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F730</accession>
    <name>I2F730_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="13" type="ORF">Theba_2099</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_014731510.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
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    <dbReference type="STRING" id="660470.Theba_2099"/>
    <dbReference type="EnsemblBacteria" id="AFK07733">
        <property type="protein sequence ID" value="AFK07733"/>
        <property type="gene ID" value="Theba_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2099"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_0"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
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    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="228"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="33698" checksum="32B3038F1A1F00F3" modified="2012-07-11" version="1">MIDYAFNGEILCMGSMNMDLVMVMDRLPEPGETVLTDNFSTYPGGKGGNQAVAAAISGARVQMFTKLGGDGFSEELIQMMKEKGVDTSRILRDPESTAGIAMIRVDKNGQNSISFTPGSNARLSPEDVEKNSDLFKRGRILLLTMEIAQETIFRAIKLAHENGMFTIVDPAPAPRNGFPDSIAPLINLIKPNESEARILTGIDVHDRESARIALQRLSSMGFNLPIITLGEKGVVGVDGNDFMDLKPFDVHCVDTTAAGDVFSGALAAALSKGMHLKESLEWANAAGALSTTISGAQTSIPAPKSVEKLLRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F739</accession>
    <name>I2F739_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mismatch repair ATPase (MutS family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731516.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2108"/>
    <dbReference type="EnsemblBacteria" id="AFK07742">
        <property type="protein sequence ID" value="AFK07742"/>
        <property type="gene ID" value="Theba_2108"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2108"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1419510at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
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    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="3">
        <location>
            <begin position="258"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="458" mass="52430" checksum="23BC98D119BDA3BE" modified="2012-07-11" version="1">MKYLDCGFEYILSLIDPVTPMGREELRAMTFLKRDEDIEAFHKRQLEVNERKSQVESLKSILARVRDIRGTISNLSPGKILDDIELFEIKSFAYWSERLRSEIGECSSWMQLPDLSVVFSFLDPDDVGTESFYISDKLDNALAVVRKKLYRLQRNREEYDEASLNELIRLNFEIEEKVRADLSGKLITYREDLQSSATTIGKIDLIVALVEFNRKLGLSKPEISSGEYEFEELVNPELAASLNKSGRSFQPFSASFDRRSVIIGGNMTGKSVLLRTVALLQTMFQHGLFVPAKRAFIPVYDAIVYYSGDKQSFLDGLSSFAGEVDHLKKALEIIHMDIRGLFLFDEIGRNTNPVEGPAFLMASAEYLSRNQRCRTILTSHYEEALEIEGAKLFIIKGLDRERMRNEIGREISYYVDHSLVEIESNAAFPREAVTIARLMGLDREFVELIIRKLKESCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F760</accession>
    <name>I2F760_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731531.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2129"/>
    <dbReference type="EnsemblBacteria" id="AFK07763">
        <property type="protein sequence ID" value="AFK07763"/>
        <property type="gene ID" value="Theba_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2129"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339764_0_0_0"/>
    <dbReference type="OrthoDB" id="209126at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658716" evidence="1">
        <location>
            <begin position="21"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="816" mass="91088" checksum="62FC3330679005A0" modified="2012-07-11" version="1" precursor="true">MRKSLPFFAIITLITATLMANCVLEFPNADIYYPEGYEEVAVNVGNTFESIRSKAIELIGNDPGRINIVLADFGANTNGLAQPHNHKTIQIFVWPADTMLSTRMNESNHYRLLLMHEFTHIAHLTYTTGFPAFVSRVIFGTEMLSPQQLSPFVEGVTLFAESSNFFSEGRLNNPMWGREMTYQNSKSNSFPGLDYALSVSGEDYRGGALYYNYLATFYDYLVKRFGIESVKQFHKEVSGRFPIIGPINASRIAFGETLDDLYLDWKEETELRATKYATLTEVRTIENGQIYDIAKTANGVIFSYSIFGEATSWNGSVERGIEEYVDGGFSRRLSDFGALTLKWHEGNIYLMTSVTERNTTSREIWSHKLPLSVRLLDKGMITAFEIYNGRLIKAVYDAKTEISTIFFDEMQLIRIPWVVKDMLILEDGSLIMMLSSSGINGAIATFKEGEFRVILDDPYLKGRGIDYYEGKVVFTAAYEEGFMDAFAVDLESLQISRLTHGANLEKAVVLDSKVYGFGHSRREKGMSVFAFDFESTPYVVTAVESDDFEPLQVEYTVGDYLKKSFLHFLNPVLRAPFVSYDGENISLGLLTVHLSHDSKHSMELKPLFTFGTNKLSFQGEYTGQFLEGVNVSLKVNLGTPNVPVATAGLSSELFQMPLNPSTRFRSYAHIGFDTSGGMTTSVPLSLKGNLFAISLEPGIKLSDGEITPLLSLDAGFAPTLGTSVNLGVGFFDDFYWYANGAQLLYRIDWGWSPMFFLKEIGIGVEVSGTNTSLDHSALYMFVNVGSTLGLGDVFPKIGIQHSDSGFGFYFELDAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F771</accession>
    <name>I2F771_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731542.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2140"/>
    <dbReference type="EnsemblBacteria" id="AFK07774">
        <property type="protein sequence ID" value="AFK07774"/>
        <property type="gene ID" value="Theba_2140"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2140"/>
    <dbReference type="eggNOG" id="COG4555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="249" mass="27749" checksum="F6D4C383A61AB2B0" modified="2012-07-11" version="1" precursor="true">MVKVERVTKTFENRRKKVTAVDSLSFVAEPGSIYGLLGPNGAGKTTTLRIISTLLKPDSGRATVMGFDSVDAPTEVRRRIGFLTSDMKLSGNLTPRELLRFYGELSHMRESDISERTKFLSDYLNMNDFLDKRIGKLSSGMKQKAAIAVSLIHDPEVIVFDEPTNGLDIITARTVTEFLKDYRKKGKTIIISTHIMSVAEKLCNRVGIIFKGKLVADDTLGGLYRRFDESSLEDVFFKIADLEGVTESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A4</accession>
    <name>I2F7A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC-barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731572.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2174"/>
    <dbReference type="EnsemblBacteria" id="AFK07807">
        <property type="protein sequence ID" value="AFK07807"/>
        <property type="gene ID" value="Theba_2174"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2174"/>
    <dbReference type="eggNOG" id="ENOG5033QNU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1341801_0_0_0"/>
    <dbReference type="OrthoDB" id="1601107at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="206" mass="23038" checksum="DC6D477A0793EFC7" modified="2012-07-11" version="1">MENRIRWGAKAISSDGKDLGKVIRVVIHPKNNEVTHLVIEKGIFNRVAKLVPIATVFFAAPDEIRLRIESKDVETLQDYEETFFVTGEEIENLESGVTPVYWLRPVGDYAELYPLPPLNTSINVPKDSKSLEPGCDIVTAEEKIVGRVKSFVLNDEGKITHLIGECGGFGSRSKKLIPIDWVEEIDECKVRVSASSVMVEKLPEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P6</accession>
    <name>I2F7P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731702.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07949">
        <property type="protein sequence ID" value="AFK07949"/>
        <property type="gene ID" value="Theba_2323"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2323"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_4_0"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="14060" checksum="82DA4C8CA709F586" modified="2012-07-11" version="1">MSFGFKNLEVWKVSKSFAKDVYELTSSFTSDEKFGLVAQLRRAAISVMSNIAEGAGRKHKKEFDHFLYLARGSLNEALAQLEISFEFGYLNRDQLDLIEKKAESINRMLWKLSKSLEKSEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T4</accession>
    <name>I2F7T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731734.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2366"/>
    <dbReference type="EnsemblBacteria" id="AFK07987">
        <property type="protein sequence ID" value="AFK07987"/>
        <property type="gene ID" value="Theba_2366"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2366"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="415" mass="46466" checksum="74662696BAB259F1" modified="2012-07-11" version="1" precursor="true">MSRRLLVLILVVTLAFSGILMAKTTLVMWDQLAATEDIVKMFNEKMKAEGKDIEVKLELIPYDQMVPKFMAALSAGIAPDLYGMDLVQFPFFISIGAFTDITEWAKELPFFDELTKGMLEIGMKDDRIYGLPYQIDLSTMLWNKGLFEEAGLDPEQPPQTWYELVEMGQKLTVDKDGDGIIDQWGFNLAGGGAGAYMFWFMPFVWGNGGRMFDDEGNVALDSYETVQALQFWADLVHKHKIAPVSSVQYGSGDRYNAFVSGKLAMFLGGNFNITSLLQDAPDMEFGVAMIPKNRGEFASFGGGSLLGITSQSKNVEAAKEFMEFAFSEEAQVGAFAPSLQLVARPSLYDNEYYKDIPQMMRFADILGIAQTPYTVKYNEIYDPVGYYFESVFLGQMDAETAVRECTKEIEKILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V0</accession>
    <name>I2F7V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489979.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2385"/>
    <dbReference type="EnsemblBacteria" id="AFK08003">
        <property type="protein sequence ID" value="AFK08003"/>
        <property type="gene ID" value="Theba_2385"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2385"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_2_0"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="107" mass="12893" checksum="BB54CB92EED2F3B2" modified="2012-07-11" version="1" precursor="true">MDIGKLATEMNRGFIQLLVMVMLDEPMYGYDIVKTLGERNFSIDENTLYPLLRRLEEREILSSEWRVEENKPRKYYFVSETGRQVRKELLRIWNEQEQLLKSFVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V3</accession>
    <name>I2F7V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731748.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2388"/>
    <dbReference type="EnsemblBacteria" id="AFK08006">
        <property type="protein sequence ID" value="AFK08006"/>
        <property type="gene ID" value="Theba_2388"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2388"/>
    <dbReference type="eggNOG" id="ENOG5034C9K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1616855_0_0_0"/>
    <dbReference type="OrthoDB" id="2059068at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="167" mass="18219" checksum="B6DB8781293A131E" modified="2012-07-11" version="1" precursor="true">MKKVSLVLCLLLAGSLLLGNLSLGLINVAAKTESLSNTPLSGFVGVDVLGIDLRYDVGLLYLGAATPFLMFTLSEDTGVKSSLIIPGIAWYGYIGLKLDFGVFYFKGDIGHTFAFGEQLQLGFSPLRLGFGMNFSPSYYIELSVDTVLQKFNETVGKIFDFKIGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V4</accession>
    <name>I2F7V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731749.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2389"/>
    <dbReference type="EnsemblBacteria" id="AFK08007">
        <property type="protein sequence ID" value="AFK08007"/>
        <property type="gene ID" value="Theba_2389"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2389"/>
    <dbReference type="HOGENOM" id="CLU_1600766_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="166" mass="19373" checksum="26AFC7275BB6946F" modified="2012-07-11" version="1" precursor="true">MKRSIATAILVTVLAVSCLSRNPTIEAYRNHFYSINFMDVENLSVKLTTEKIDISRNEKRMLKDGDILVYLTDEDRLGKMVILELDKNESGMLLFDFVTYDKNGKVFTEKKDVKFHSSYVFDFDKGIFPKEIEGVKLWWHSTDDIEMYLVPWAPTKLLKYPNAEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X1</accession>
    <name>I2F7X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative subunit of the multisubunit Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731765.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2407"/>
    <dbReference type="EnsemblBacteria" id="AFK08024">
        <property type="protein sequence ID" value="AFK08024"/>
        <property type="gene ID" value="Theba_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2407"/>
    <dbReference type="eggNOG" id="COG1563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105380_0_0_0"/>
    <dbReference type="OrthoDB" id="1767834at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK08024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="229" mass="25463" checksum="459ED31E7320C381" modified="2012-07-11" version="1" precursor="true">MSFVIVAISSLYIVSAIIVLSSKTNFQSVIWFGIVGSLSAIIMMIIGAPDVAMTQFSVGVALVLIVYIMALKKQRRVRLGIVEVPSMIEETPSGFRGLEWEIIQLVDEKEGYHLEPVKFSSKEEALVAIENHDIDLICGALTEDDVTGRTKGIPYLETSIFLCNGEEIDFVRLKHLSRNSLSPTPEFLRKSSYVFVVSTNSPDLEKDILEGLEFIRSSGNIEEIVGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F811</accession>
    <name>I2F811_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731797.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08064">
        <property type="protein sequence ID" value="AFK08064"/>
        <property type="gene ID" value="Theba_2452"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2452"/>
    <dbReference type="HOGENOM" id="CLU_2508858_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="85" mass="10157" checksum="CABF220E396E806E" modified="2012-07-11" version="1">MKNVSGIRLTLPDFQGKDFTYEMYPVYEKDWFSLNIALDVSDFIATAGIEVEPPVRFHIGIAKKWQYLFDFKRYFDLLIGFEFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F814</accession>
    <name>I2F814_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731800.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2455"/>
    <dbReference type="EnsemblBacteria" id="AFK08067">
        <property type="protein sequence ID" value="AFK08067"/>
        <property type="gene ID" value="Theba_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2455"/>
    <dbReference type="HOGENOM" id="CLU_1037495_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="268" mass="31309" checksum="6D36826A680D63A0" modified="2012-07-11" version="1" precursor="true">MNFNKSVFAKIGFILIFIGIILLLIGFAIPVFILLSIMLFLLAIALLLSSQDFPTAEQCLTFAESKLHPGEVVISSVFVNRFMEGVTWDGKEVRGYVRYFFVFTNYFLRMYLPKQRWPWQNEEVRFSREDTMGCDTLVNYTFTNPGSRRQNFSINFWTGSVVGYTEKEEDAYQLQQAVDQILQRQRIGVNRGSTNLSQEIVELNRLMEEGLITEDEFGRAKELFLGKPKDDRDYVVKLLRNLYVLYKTDVLSESEFNMKKWDILSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F816</accession>
    <name>I2F816_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489852.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2458"/>
    <dbReference type="EnsemblBacteria" id="AFK08069">
        <property type="protein sequence ID" value="AFK08069"/>
        <property type="gene ID" value="Theba_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2458"/>
    <dbReference type="HOGENOM" id="CLU_2070316_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13134" checksum="B95685D5F06CA0DC" modified="2012-07-11" version="1" precursor="true">MKKTLAFLIIAALCVTALANGLLVVTLKDGSVYEFYLDEIESLVYVAEDELPLEPKYMSFEKLVFVPGEEINLYFFGTSGLGLTPGSESFLRILRMEASRKTTCTTFSMLTSVAWQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F827</accession>
    <name>I2F827_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731812.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2469"/>
    <dbReference type="EnsemblBacteria" id="AFK08080">
        <property type="protein sequence ID" value="AFK08080"/>
        <property type="gene ID" value="Theba_2469"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2469"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_0"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="5">
        <location>
            <begin position="351"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="465" mass="51006" checksum="B3DDADA3C5407820" modified="2012-07-11" version="1">MKDRKREFDAIVIGSGQGGTPLVLSLADEGWRVALVERKAVGGTCVNEGCTPTKTMIASARVAHLVQRSEEYGVVAGESSVDIQKVIQRKRQVVESFREGSRKRIIDSPNLSLIEGSASFVGDRELEVRLKEGETELIEARTIVINTGTSPATPKIPGLERVEAHDSTSIMELDELPEHLIVLGGGYVGLEFGQMFRRFGSRVTIIQRDKQLLSLEDEDIATLVLEILRGEGIDVLLESEPIEIDSCEGNRNSVRLRFSDKEKPVVGSHLLLATGRVPNTPDLNLERAGVKVDGRGFIEVNSKLETTTKNVYAIGDVKGGPAFTHISYDDFRVMKENLVNGRGLTIQERFVPYVVFIDPQLGRIGLTEKQAVSQGRQFRVATLPFDRVARAIETNETRGMMKALVDSKTDRIIGAAILGVEGGEIMSAIQIAMMGNLPYTSLRDGIFAHPTFAESLNNVFMGLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F834</accession>
    <name>I2F834_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731819.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2476"/>
    <dbReference type="EnsemblBacteria" id="AFK08087">
        <property type="protein sequence ID" value="AFK08087"/>
        <property type="gene ID" value="Theba_2476"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2476"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="289" mass="32359" checksum="58CF150DB44EEDCF" modified="2012-07-11" version="1" precursor="true">MRMKIRTREALQGLAFISPWLIGFLIFTLVPLVRTFWLSLNEVRVTASGIRTFFVDFKNYKDAFLTDVTFSGMLIDYALQMAVYIPVIISFSMAVALLLNLKIKGQGLFRTIFFLPVIISSGPVLAELTDKGAMTFEGLTNLGFLVNLQATLPPSIARLLAFAVGSFIVILWFSGVQILIYLASLQKIDRSMYEAARIDGASGWQILWKLTIPSLIPITFINIVYTIVTVSTFSTSAVIQKIQTDMYRPEKGLGYASALSWIYFLVMLAIIGMFVLINVIYRKKGGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F840</accession>
    <name>I2F840_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731825.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2482"/>
    <dbReference type="EnsemblBacteria" id="AFK08093">
        <property type="protein sequence ID" value="AFK08093"/>
        <property type="gene ID" value="Theba_2482"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2482"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030564_0_0_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658603" evidence="1">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="436" mass="48901" checksum="EAAB5A21C9E863E1" modified="2012-07-11" version="1" precursor="true">MKKLVMIGLVILLVTAAMAQAVTIVYANWNLSLDVEKKIVEEFMKTHPDIKVEFADLDYGKYEDSLIAAAAAGKLPDVIMIPNIPMALVNDWALDITAMTAKDAEWENIPAPLRGATVYNEKVFAVPSGFYMLGYFVNEDLFTNYNVPQLPYAPDWNTMLSAIRKLTIPRDGVLGIAEEVQIPEWFPATKDPALGYFTWDGEKYNLDHPAFIEGVKIAKQLFDGKFVFDSLPEEQKQQYNAGWYGDVWNQGKIAIRWSGTWDTTSFATLPFPSRFIGVPEGKVTIVGDFFIISKTTEYPEQAYEFAKYITFAKEGILKRLEIDTANQWTSLPLTTEQAVLDEYFKVKKLFPGIDEAFARISEGIVEGVKIVPGYIQSRWTAPTGIKVGDNDNASIGDVIWNSMRGNVNIADYAGQLNKLANEQYKNAIEKIAVMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F853</accession>
    <name>I2F853_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731838.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2498"/>
    <dbReference type="EnsemblBacteria" id="AFK08106">
        <property type="protein sequence ID" value="AFK08106"/>
        <property type="gene ID" value="Theba_2498"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2498"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_0"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="441"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="661" mass="75185" checksum="C32BBB93BE18A1F3" modified="2012-07-11" version="1">MSDRYLTIEEQLSLPIVNNPVISPDGKKLAYILKRADWNTNKYLQTVVVYDAAIKTALHVSNDEFDCSLPDWSPDSKKLAFLQKTGGENKNDVMIFDFEEKRTFKLLTFENDISQIKWSRKNDGLYLVAASPESDELKKRKENYGEFEYIDEEPKNSSLFFIHLSRAMKKYSSRFELPKDMRSEETLFDKLTDEKEFHVSSISLSPDGNYVALMAPPTSDVNDFDEARVMLIDSERKLKELPFKHPRGFVFSPDSKELAVVVPDGEDPWMDNGAIEIVDLSNLSKERINVEDDLNVELVSWTERGFFVSWIENSTISLGLLDMNGHLERLTDQDELVLASSVTYDGEHIATAMGTNAEPLEIYLNGKKITKTAVSYPERKRVMKERISWKSYDGTEIHGVLNLPEDFDSSKRYPLVVLVHGGPTWTALAAMITSSYYPVEQLVSKGVLVLEPNYRGSEGYGRDFRKLNYRNLGVGDYEDVVSGVDHLIEKGFVDKDLVGVMGWSQGGYISAFCATYGNRFKAASVGAGISNWVTYHVNTDIHQFCHRYLGNNPWEDPQIYELTSPMTYIKNASTPTLIQHGGSDTRVPPPNAFELYQGLREMNVPVRLVIYKGMGHVADKPGLHRAIMRQNLAWFSHYLLDEPLEEALMLKQSEIEKTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F854</accession>
    <name>I2F854_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5050 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731839.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2499"/>
    <dbReference type="EnsemblBacteria" id="AFK08107">
        <property type="protein sequence ID" value="AFK08107"/>
        <property type="gene ID" value="Theba_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2499"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674069_0_0_0"/>
    <dbReference type="OrthoDB" id="23647at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="DUF5050"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5050" evidence="2">
        <location>
            <begin position="111"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="408" mass="46330" checksum="C4F0723591CDFF1A" modified="2012-07-11" version="1" precursor="true">MKITFLPHSRLGKWGFSLSLAFILLLFAQIQFSLIPLPVFSVMALGVAGFVLSIIAFIKRDRALGTLLSIIIGAVIIFVFGSILVMSTDLFKGFPVAKDYLEKAEGNDMSGDGMNLGDISQSGEQIFFVEKNRLYTINIDWTNRREVTDSPVSSIFLSGDWIYFTNDRDVSNLYRMKKDGSEQMKLSEDNVAHFYVLGDHIAYSTKKTLAEFNEIKKEALNTEDATVESDVGTLYMMKTDGSKKIALCKVSLEPGRVMISEEWIYFEDYQKLCKVRIDGSDYTVISEKGRLGFVENGWVYFISVLDPETRAYDDLEICRMKKDGSEITVLSSVNKVSSSCFDNGWFYYVLHSEKGLYRMRPDGSERERLNKINIWQFDGVAGNWMYITDYAGPRYRVKLDGSVGTRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F881</accession>
    <name>I2F881_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator with putative antiterminator output domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731859.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2530"/>
    <dbReference type="EnsemblBacteria" id="AFK08134">
        <property type="protein sequence ID" value="AFK08134"/>
        <property type="gene ID" value="Theba_2530"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2530"/>
    <dbReference type="eggNOG" id="COG3707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_65_0_0"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="126"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="21985" checksum="4C6F5FE11B539992" modified="2012-07-11" version="1">MDNSLNILIAEDEYIVLRGLKETLTDLGHNVIGEAMDGETFVKLALEKDPDLLIVDINLPALSGIEAIERIGKVKLVPSIIVTGYSSEETVKRANSAGVFNYLVKPVDEKELKPAIEIAMGRFKEFVLLKKELQEQGEALEARKLIERAKGILMDRNGIKESEAMKLLQKISRDKNLKLVVVAREIIEADNTLHYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F894</accession>
    <name>I2F894_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731872.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2546"/>
    <dbReference type="EnsemblBacteria" id="AFK08147">
        <property type="protein sequence ID" value="AFK08147"/>
        <property type="gene ID" value="Theba_2546"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2546"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_0"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="232" mass="25793" checksum="FF907BCB54E22AF4" modified="2012-07-11" version="1">MERIDKFSKRFDSTLLKATATIKESEVFIDDSVSCDFRAIVVPWYLMDRVVKKVRGTDISAACGSGFPFGFETTETKAYMIRESLRLGPEVRDIDITANISAMKSGDWDYFEREVSYLSGLLKDVTCKVIIEVSYLDTVEIEKACSILMKLPHVDFVKTGTGYGSRPTTLEDVRIIKRVVGDEKGIKVSGGVKSLSQVEDFIAAGADIFGSSNAVAIYREFTEKYPGRTDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B9</accession>
    <name>I2F8B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2572"/>
    <dbReference type="EnsemblBacteria" id="AFK08172">
        <property type="protein sequence ID" value="AFK08172"/>
        <property type="gene ID" value="Theba_2572"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2572"/>
    <dbReference type="HOGENOM" id="CLU_1693416_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="17432" checksum="BE4969EE53D0E9B5" modified="2012-07-11" version="1">MQFQVAVKKLNKTGLGSRKENRLINSRFYCNLESYPDIGLWKSLTLSSRTCLGIKVSILSKNEEPGRAASERRTDASWRKRRTVDEKRFFISVQGFCKGSRSQTSISLFLASWRVSASIASCVATSLPRTLFRASLPGMIFPALLPRASKPHFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C8</accession>
    <name>I2F8C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731899.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2581"/>
    <dbReference type="EnsemblBacteria" id="AFK08181">
        <property type="protein sequence ID" value="AFK08181"/>
        <property type="gene ID" value="Theba_2581"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2581"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453300_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658443" evidence="3">
        <location>
            <begin position="22"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="480"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="602" mass="68318" checksum="A53B3BC5BA298543" modified="2012-07-11" version="1" precursor="true">MKNGKAFLSFFLVLLSTFAFADKLTFGGDSAYPPYEFVDENGEYTGFNVDLMKAVSRVAELDIEIELGEWDLVVEKFKSGELDGLIGMAVTPERQKIYGFSIPHNTLHMAIFYRKGSQEPTVDDLRGREIVVQRNGVMDDYLLENSITDKIVAVESPLDGLKLLSSGTGDFGLFEKYQSLYFAKENEIDNLEVSGATVFERDYAFATAKDDFALLNKLNKGLLLVRESGEYRDIFEKWFGSANWFEQNKRNLLVTAGILVFFVIGLFVLWFWNHTLKVRVKARTEELERKAIENEALRAKIRSLHDIAFKMESCTEEEDVFDLIVKAATEILSFDYYSLDVVEGDYLVVKRHSDNIEVNSRVPKYEGIAGRTLRTGKTIILDDVSKEDDAMPSSSKIKALLSVPIGTIGVFQSVTIESGSFNNEDAELAELLMFHALGALERIKKTREIQFLAFHDSLTGLYNRTFFDEEVSRVDTSRNLPISVIFADVNGLKGLNDRFGHFYGDDYLKTISCTIKESCRHEDLVVRWGGDEFVVLLLRTDTEMAEEIVSRIEKNLSKIDCFAVEASVSFGVATKRDILTDFQDVLRNAELAMYSKKRELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J0</accession>
    <name>I2F8J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731949.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2643"/>
    <dbReference type="EnsemblBacteria" id="AFK08243">
        <property type="protein sequence ID" value="AFK08243"/>
        <property type="gene ID" value="Theba_2643"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2643"/>
    <dbReference type="HOGENOM" id="CLU_1265707_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="218" mass="24116" checksum="7DEFB8CC88CA9EBD" modified="2012-07-11" version="1" precursor="true">MKKIVWILIIMSLFFSSKILSNVLIEGERSLLDYLVEGKALNMAVDISLIQSVQEKVPGEIQAVFLLPEGSVRVITDSHFVTLSETGEIYEIYEITGSGTTLKVGIIDALSLVSVQTRENVFGIFLVQEENSYFWHVVTGTRTFRLASSFASTLSIKSNEEALEEINKGLQRSEEVRENQHPSEKQGKPEDPGKPEDPGKPDDPGPPNTPPGKENGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J4</accession>
    <name>I2F8J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731953.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2647"/>
    <dbReference type="EnsemblBacteria" id="AFK08247">
        <property type="protein sequence ID" value="AFK08247"/>
        <property type="gene ID" value="Theba_2647"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2647"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_2_0"/>
    <dbReference type="OrthoDB" id="977242at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="119"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="471" mass="52515" checksum="3CC157663A8BFAC4" modified="2012-07-11" version="1" precursor="true">MSLQEGFPFRSPGIDLIKTNKGGILKFIGKTVALYVTQTDAIFLSLCDGTRSMSKIAILLSELYKVDSRTILNDITRLAEKLHELHVLVMLPMALEKRLSTMEDWHEFVFIPADESCPVVPARISSIGFALTNYCPYNCEYCYGAFGSENEAFYLPTAKVISIIEDARKLGKVEYVSLGGGDPIAHSGLSEIVSYLESCRITYELSTKGLLLSKKKVDELVVAGIRNIQISIDAWHPEVWSEIVGLPKHAFNSAIESFIYCKSANVSTRARITLSRRNLEELPYLLENLPFLGVSEIRIVTLMPSGRARINEIPNRDQIESALEVVEAFRSKYGNKPEIVFGVHRYTSSLSCGGAKLAMQIGADGEVLLCDVVEGLDRARFSYGNVFRNSIEEIWFSKQADAFRTNREISECLDCVKFAQCNGGCRALAFSYYNSYDSPDPRCSRISGKEGDIFEWPVKQQPDGGGEKYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P2</accession>
    <name>I2F8P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ade</name>
        <name evidence="8" type="ORF">Theba_2696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2696"/>
    <dbReference type="EnsemblBacteria" id="AFK08295">
        <property type="protein sequence ID" value="AFK08295"/>
        <property type="gene ID" value="Theba_2696"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2696"/>
    <dbReference type="eggNOG" id="COG1001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027935_0_0_0"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="66"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="403"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="582" mass="63416" checksum="BAFF82536ADF81E8" modified="2012-07-11" version="1">MGTNIIDIIPVARGDRPADVLLKNCKIVNVFSGEIEEANLALFKKRIAGIGDYEDGLEVIDLEGSYVVPGLIDAHLHIESSMVSPVEFSKTILARGTTTAIADPHEIANVMGLSGIEYMIKSTEGVPVNLYIMIPSAVPASAMETSGARISVMDMIGFVEKFQNRVLGLGEVMNFPDVINGDRDSIAKIELIRHKYKKIDGHIPGVLGKPLNAYICAFVRSEHECTYVEEAREKLSRGMQILIREGSVERNLVALLPLINEKTYPFVSFCTDDKHPDDIIREGHIDYNIRKAIEHGIDPIIAIRAATINTARHYNLRSMGAIAPGYKADLVVVDNLESFNPRIVFKDSRIVARDGRLVTDVISKSFPQERTNTFKCQKICEDDLRVKAEGRKIRVIELLGSEVLTGGTIADAKIENGCVVSDVDSDVLKLASVCRYCEGKSMSVAFAKGSGLKKGAVATSVGHDSHNLGVLGVNDSDMVCAANRVIEMGGGLVSVVDGKITSELPLKIAGLMSDLTSREVAERLTELKEATKIMGSTLPDLFMTLSFVQLSVIPKLKLTNLGLVDVEKNDFVTLFVEEGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S5</accession>
    <name>I2F8S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732021.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2734"/>
    <dbReference type="EnsemblBacteria" id="AFK08328">
        <property type="protein sequence ID" value="AFK08328"/>
        <property type="gene ID" value="Theba_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2734"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="8"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="106"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="307" mass="33409" checksum="E13A26844CA362B0" modified="2012-07-11" version="1">MLRLHANDPLDKDAMKILEDSKLFEITAEHLDKDELLKKMPEIEILVVRSATKVTSEVIDAGKKLKLIARAGVGLDNVDVEAAKRHNIMVRNTPGANAISVAELTFGLLLSLVRHIPRGTYGIKEGKWEKKELKGTEIFGKTIGLIGFGAIGREVAKRAIAFGMNVCAYDPFVKETEMEIELVSSLDSLFDKSDVISLHIPLTAETKHIVGEKEISAMKDGVIIINTSRGGTIDEQALYNGLVSGKVSGAALDVFEVEPPSDELRRKLIGLGNVICVPHVGASTTEGQKRVGLEMAKIIVEECKSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M5</accession>
    <name>I2F1M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent glutamate synthase, homotetrameric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730001.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0077"/>
    <dbReference type="EnsemblBacteria" id="AFK05828">
        <property type="protein sequence ID" value="AFK05828"/>
        <property type="gene ID" value="Theba_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0077"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_0"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="138"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="459" mass="50146" checksum="E72AFC4D29F57117" modified="2012-07-11" version="1">MAEKFKVRMRELDPSERVNSFEEVALGYTKEEAIAEAKRCLQCKHKPCVSGCPVGIDIPGFIKALREDDIEKSTRILKDANNLPAICGRVCPQEKQCELACVVGKIPGSEPVAIGRLERFVADQNISLETAVKPSVNKRVAVIGAGPAGLTAAADLAKEGFSVTVFEAFHTAGGVLVYGIPEFRLPKEIVAKEVEFVKSLGVEFRFNQIIGRTIPFEEIKNEYDAVFIGIGAGAPRFMGIPGSNHNNIFSSSEYLTRTNLMKAYLFPLYDTPVKIKDRVAVIGAGNVTMDAARTVKRLGAKEVHVVYRRSEEEMPARIEEYHHAVEEGIIFHWLTLPVEYIGDINNNVTGMKCVKMTLGEPDDSGRRRPIQIEGSEFVMEVDMVIEAIGQTPNAILKAGFPAVRLNKWGSIDADEASGRVDEGIYAGGDIVTGSATVIEAMGAGKRSARAIKSYLLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P7</accession>
    <name>I2F1P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730019.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK05850"/>
        <property type="gene ID" value="Theba_0101"/>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_1"/>
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        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="434" mass="48731" checksum="581D24B049D21E5E" modified="2012-07-11" version="1">MRVGLIHYRAGLMDGVSLEMEKWRKVFSRMGHSVEIIAGNNAPGVDIVIPEIEYNDEKNEILNSKLYGSTPSSESELLDELSIRTAEILGSFRSVLSDFDLLIPNNIWSLGWSIPAGLALHDFAEESGKPFISHNHDFWWDRPYYSSPYRSVMELLENYFPPDLPNVKNLTINSISASDLFERRGIRATVVPNVMDFSGPVSISDERIRTLRSEAGIEKGDIVFLQATRITERKAVEISIRLIAAFNNIAGSLKGKKLYNGEPFTGRAVLVYSGLTERQSMDYRKKLDELANKLGVKAIDISSSSSLSQAAFFESYGVADIVIYPTVFEGWGNQLLEALVYRKPLALFRYSVFKSDIQNSGISFVDLGDRYIYSDGLAEIPEQTILSAVKEITELLFDREKYEETAEKNFQIGREKFSLETLGGIVKGLITDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F226</accession>
    <name>I2F226_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFK05979">
        <property type="protein sequence ID" value="AFK05979"/>
        <property type="gene ID" value="Theba_0245"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
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        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="316"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="605" mass="67568" checksum="87C0557332DF1BDA" modified="2012-07-11" version="1" precursor="true">MRKSALLFLLVLIMVFFTGCDFPFITRDDFTQRMDALEQKIDSLAAGQKKLAQLEDAVEELAFRINFVQAIEPTYAGYEELEAVRAELQIIKNMLAESVIDSASSAAIVKTLYDKIDGVLTSTVENNIITREIDDLNRKVQALESLNSSRYSELVQRISEIGTYDSSIDEAKYEELLQRIEEIKSAEVVVVQQESDEDDRRYEELVNKVEELAARTDISVLDSAKYDSLAKRLAELEQTVGSSVIDSEVFNELVSRIDEMDSRTRELADNLQSIERQEEPEEKNFVTMATFLGEISDIRSRLGAAAYETIEPTSHVSYIVKSGDNLWSIAQAYGVTVEQLKAMNPEIKNWDLIYRGDEIKIPLSLDNLMAKASIATHFGLNLGVDFLVDSIESNFGSYDYGYANPGMDLTVPPGSRITAFLPGKVILSERVNDLYGEMVVVDHGNNMKTVYARLGSRMVMKGDFVRVGDTIGSASDAKGNLHFEFWKADVPVNPADIIFENVGTFEVTMYTEWDDAKNPTSPSFKMTASGDFVKGYRTVAADPVVIPLGSIVYIPFFSSSPNKGFFVVEDTGSSIKGNKIDVYTHDFDTASNFKEDLLVYVVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F230</accession>
    <name>I2F230_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0249"/>
    <dbReference type="EnsemblBacteria" id="AFK05983">
        <property type="protein sequence ID" value="AFK05983"/>
        <property type="gene ID" value="Theba_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0249"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_6_1_0"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="388" mass="42282" checksum="0E1FADB78166D105" modified="2012-07-11" version="1">MVPLFLSGASSSARETATEIFIYSNLGVMALFSQFFQSKGFSSVEIGILMAVTPILSVIANPFWFKRSRRRGGALVMGTLSIVSAITVWGIFLTPTFETSLIAMSLFAFFAVSIVPISESVVVPSLRSKGKRFNMARAFGTVGYSATALISGIALRAGFVMIFIIASVSLLTAAAVSRAYPSKRMLGRSESERNSTPLPVEFYLLVLAGVASITVGAFGSTFLPLLTSDMGYDLSSVGFSFSLMALSEVPFLLFAEKIIDRIGNTRLLLVGIFATGLRWFLTSIAPSFPVFLLFQALHGINYIVVYYSVTNFIHKNFEENKAMRALTIYWMSTMGLSYLLGSVLGGVLIRAFGIRRMYTIVGISGMVMAAFSSLLFAALRKRGRFTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F239</accession>
    <name>I2F239_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730150.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0258"/>
    <dbReference type="EnsemblBacteria" id="AFK05992">
        <property type="protein sequence ID" value="AFK05992"/>
        <property type="gene ID" value="Theba_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0258"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_8_1_0"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="439" mass="49109" checksum="2404D2A215AF62C6" modified="2012-07-11" version="1">MEELRIEKLIAGGFSLARTADGKVALLDAGYPGEVVEASKKKGRSDFHTMKVERVLVPSNSRRERLCRNFPVCGGCDWQTLDYSEQLFWKREVISEQFKRVGKIELEDFEIVPSPRETNYRLKMEYVCHGGKDGLSLGLYRRNSNSPVSCQGCVLGLKDFEKARSGFEEILRKTAIVPYNRVTGRGELKHVILRGNGREIMAILVTKGECLPDENRIVLEVRKKLPYVSTLVHLMNANDRVVMRGVSRTLFGEGVIDQELSGRKFEIPPVAFFQNNLEVTESIVSHIFNEMKDTAGDSLLDLYSGIGTFSITVGKKMGRVTAVESNPVSVKALKANSNLNGMFGIEIVSSDVIEFLKSDQRHYSTIILDPPRSGVGSEIGLLDKFGASMVFYVSCDPTTLARDTAKLRESGYKISSVKAFDMFPQTWHVETVVCLVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F287</accession>
    <name>I2F287_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730183.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0310"/>
    <dbReference type="EnsemblBacteria" id="AFK06040">
        <property type="protein sequence ID" value="AFK06040"/>
        <property type="gene ID" value="Theba_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0310"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_0"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="464" mass="52019" checksum="CBDE77836E1C6050" modified="2012-07-11" version="1">MREKVFLDSSRFDFLSNTKYRFMSERGFGESQVIDISKRKNEPEWMLKKRLQSFKAFSLSSKPGFGVSTESLDLSRIISYLGPDSDKHRSWDDVPQEIRETFEKLGIPEAERESLAGVGAQFDSEIVYQNIRKELEELGIVFLDMETAVKKYPELVRRFFMKAVPPTDHRFAALHGAVWSGGSFVYVPKGVKVPLPLQAYFRMNVESSGQFEHTLIIADEGSDLQFIEGCSAPRFNDLNLHVGMVEIFVLKDAKVRYSTIQNWSKNTYNLNTKRAIVEEGGTMEWISGSLGSMKTMLYPSSVLRGRGARAEHLGITYAGPGQHMDTGSKVIHLAPDTSSLVDARSISVGGGWAFYRGFLDISRSAMNSRSSVKCTALMIDNESRADTVPIIQVMNNAAEVGHEARIGRLGEEEIFYLMSRGLSESEAKAIIVRGFMEPVSHQLPVEYAVELNRLIDTEMESSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F292</accession>
    <name>I2F292_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730188.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0315"/>
    <dbReference type="EnsemblBacteria" id="AFK06045">
        <property type="protein sequence ID" value="AFK06045"/>
        <property type="gene ID" value="Theba_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0315"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497693_0_0_0"/>
    <dbReference type="OrthoDB" id="1428822at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="565" mass="65221" checksum="DE5C649DC34987BF" modified="2012-07-11" version="1">MNDKTVIVYLPLKPEMAKANNLPIKLPILVQDMGNVLDLDRIDLDIIIRGLEAQCLLESDDYYESYLIYYYYEAFKRSLNSGNFDESKKFLERAGKIKKDYRYHFYLGLLLREEGKIELSEIELRQAIEMNREFYIGYYELGRLFQLQEEYDEAVSSYVKSVEKSGGQFPLPFVATIDCFISKGDYSAAMEVIDNVNEQFPLYSEILLRKGVILNETQKYSLAEATFSENIGLGEDWKSFYNRSFSRARQGKLFEAYDDLKTAFKISGNSEVLYELAISEKNMGMLEDSLSHCERYYNETLDEKALVLKARILDMMGDYDSAIEATEERYVELKNVLLIHKYLAEGKIKRDLPFEEPLNEFYYRSLQNKIARDGFSDCRLIESGRINIERLTELLTELGIDDLTERISLLSEGLLPGKTREVTLPEVGLFTTLIFEMQFFPSQQEYLSYLMSFLVSGKGKTTAIFKTLLYLERWSLSGLPFTIEAFVDEYIEEIKDLSFDFGLNIARIIEYGGSDIDTFEEEQDVDPEEAVLTIIYSLEKGTISELRTPDYSLNNYISRLSGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A7</accession>
    <name>I2F2A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730201.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0331"/>
    <dbReference type="EnsemblBacteria" id="AFK06060">
        <property type="protein sequence ID" value="AFK06060"/>
        <property type="gene ID" value="Theba_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0331"/>
    <dbReference type="eggNOG" id="ENOG5031BK3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149135_0_0_0"/>
    <dbReference type="OrthoDB" id="2087344at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="141" mass="16018" checksum="DE83D86C4B2E9B71" modified="2012-07-11" version="1">MQVSLDQFLGAIMSRVDNLEATIDDLRLRTNIAMRLVKSVVPELTRDDVEKAVSEELEITKNAGMMEESDEIEEISSRLTDSIFEWLQGDVAELREKMDAYRKKLQEAMEAEKNRVIDVAPAGFVNQLGQEKGQKKGKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D5</accession>
    <name>I2F2D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491939.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0359"/>
    <dbReference type="EnsemblBacteria" id="AFK06088">
        <property type="protein sequence ID" value="AFK06088"/>
        <property type="gene ID" value="Theba_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0359"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_2_0"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="34155" checksum="CA55118E14FEE00B" modified="2012-07-11" version="1" precursor="true">MSWIEAIFAILVNPLFYKLTLLSATPLIFAALGGTYSEITGVTNIALEGIMLMGAFTSIVFTLITGNAWLGVLMAVIIGTGFTWFHAWASIRWSANQIVSATALVIIAQGTTSFLMIPIFGNEGQTDFIGRVPYLDAGWLSEIPFIGDIFGSMSPFTYLAIIAVIASWFLMYKTPLGLRMRAVGENPEAADTLGINVFKIRYFGVLMSGVFASLAGAFLSVGELGRFVENMIHGRGFIALAAMILGNWNPVGAMWAAILFGAAEAMNLQLQSSSIVSVSSSVKPLFNMLPFVVTLIVVGGFIGKTRSPAASGTPYEKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E7</accession>
    <name>I2F2E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="11" type="ORF">Theba_0371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730227.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0371"/>
    <dbReference type="EnsemblBacteria" id="AFK06100">
        <property type="protein sequence ID" value="AFK06100"/>
        <property type="gene ID" value="Theba_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0371"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_0"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="349" mass="38195" checksum="8761D6FF0871A850" modified="2012-07-11" version="1">MLSKDKKNALERAIKDIEKQFGKGSVMLMGDKEEHKSIEVIPTGSLAVDIALTVGGYPRGRVVEIYGAESSGKTTIALHAIAEVQKRGGIAAFIDAEHALDIHYAQNLGVDVDNLLISQPDYGEQALDIVDGLIRSNAVDLIVVDSVAALVPRTEIEGAMGELQVGLQARLMSQALRKISGNVSKSKCIVIFINQTRMKIGVVYGNPETTTGGVALKFYSSVRLEIKRGSAIREGNTVLGNETTIKVVKNKVAPPFREAKVDIIYGQGIEHANELFNLALSENMIERKGAWYTYISEDNNEVSLGQGKSNGVEFMKENPELILEIENRLRAKYNLPLLEAKKEEKEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H7</accession>
    <name>I2F2H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491997.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0402"/>
    <dbReference type="EnsemblBacteria" id="AFK06130">
        <property type="protein sequence ID" value="AFK06130"/>
        <property type="gene ID" value="Theba_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0402"/>
    <dbReference type="eggNOG" id="COG1833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115699_1_0_0"/>
    <dbReference type="OrthoDB" id="1750345at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10441">
        <property type="entry name" value="GIY-YIG_COG1833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="144" mass="16478" checksum="4D385C5E0942601E" modified="2012-07-11" version="1">MAGLLSYNIYIMDYNKGDYIVLLFLREAAEVSSSKKKWHLESGYYLYVGSAMNSLTERVKRHLLEEKKKHWHIDFLREKAEVLAVLLLPAKTSNEEELSNLISNYCIAVPGFGASDCKTDSNLYRVGFGCIEKVFSSIVGKWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I2</accession>
    <name>I2F2I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730251.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0407"/>
    <dbReference type="EnsemblBacteria" id="AFK06135">
        <property type="protein sequence ID" value="AFK06135"/>
        <property type="gene ID" value="Theba_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0407"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_15_1_0"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="410" mass="44688" checksum="81AF4495BFB92167" modified="2012-07-11" version="1" precursor="true">MRKSLLAVLLLSVSLLFASGSVEIFSWWTGGGEEEGLAAIYEVFKAKYPDVEIINATVAGGAGTNAKAVLKTRMLGGNPPDSFQVHGGMELIDTYVITGMMEPLTDILESWGILDKFPKDIMTICSYEGEVYSIPVNVHRGNVVFINNEILEKVGIDEVPSDGPGFLEVCAKIKEAGFIPLSLGDKDKWEAGHLFETVLLSALGPDKYNGLWDGTTSFEDPGIERAIVIFEELIKYVNEDHAALTWQDATRMVFDGKAAFNVMGDWAEGYLKTLGWTPGVEFSWMAVPGTEGSFMVVTDTFGLPKGAPNRENALKWLEIVASVEGQDAFNPIKGSIPARLDADKSLYDPYLTWSMEDFSTNALCPSIAHGSAAPEGFITELNDAVNIFITTKDRAAFLSAIESAAEDYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L2</accession>
    <name>I2F2L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730280.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0438"/>
    <dbReference type="EnsemblBacteria" id="AFK06165">
        <property type="protein sequence ID" value="AFK06165"/>
        <property type="gene ID" value="Theba_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0438"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045353_0_0_0"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="215"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="46790" checksum="2BFDB4E53125CA7E" modified="2012-07-11" version="1">MRSTQVNKKLLKDYQPFVEEEVIESIIELSRELKGLRVLHVNATSFGGGVAEILHTLVPLMKDCGLEVDWKVIDAPPQFFDLTKRMHNALQGKEDFLSEEDKRLFEKVAKDNAAYIGIDEYDVAVLHDPQPVGLPAFANFGNCKLVWRCHIDTSSPNEVFWNYLNTFLSYYDAGIFTLKSYAKDGIAIEKIYDIPPSIDPLSNKNRMLSEEEMKKAMTKLGLVSGRPVIAQVSRFDPWKDPMGVVDAYRQLKRKFPDLQLLLIGSMASDDPEGWKIYEDLLRYIGMDYDVKVLSNFHGIGDIEVNAAQRISKVVLQKSLREGFALTMSEAMWKKTPVIGGNVGGIPLQVHHGVNGYLVESVDETVEYTERILENPDLAKELGRNGYEIVKKHFLCTRHLLQYLELFRDLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N4</accession>
    <name>I2F2N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730301.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0461"/>
    <dbReference type="EnsemblBacteria" id="AFK06187">
        <property type="protein sequence ID" value="AFK06187"/>
        <property type="gene ID" value="Theba_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0461"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="540" mass="58829" checksum="A4EECAB5A39B4BDE" modified="2012-07-11" version="1">MSKPITVLVSIDSNSLLLGARHLKNYLNTLVENYNLSSMVEILETGSFGEYGRGVLFLVLPDDVMYSAKSEVDIEKIVLEHLLKGRKVRDLVVADFDSGGSVEATKSTSEVRIVLRNAGSIDPRNLEEYIALDGYQGLAKALRMTPEEVIEELKKSNLRGRGGAGFPTGLKWEFTQKVRSDEKFVICNADEGEPGTFKDRLIMEGDPHSVIEGMVIAGYAVGASKGYIYIRGEYFESVSSLRDAISKAYEYGLLGQSVLGTEFSFDLSVRLGAGAYVCGEETALIESIEGKSGRPRLKPPYPPVSGLYGKPTVVNNVETFACVPPIIDKGAGWFRSIGTQSSPGTKVFSLCGDLVKRGIVEVPMGTSVRDLVHKFGGGIPKGRTLKMVQTGGAAGTFIKPEEMDAELDFDSFKKSGASLGSGVILAIDETHCAVDIAKNLMEFFAHESCGKCSPCREGTRVIVYILDEFSKGRGTVEMFNQLYDISETMEESSFCGLGQSVPIPLRSILDRFKDEFLSHLNSPGCPVGVCEFDKPEKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q1</accession>
    <name>I2F2Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK06204">
        <property type="protein sequence ID" value="AFK06204"/>
        <property type="gene ID" value="Theba_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0478"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="74" mass="8236" checksum="D41A5DBDEBFC65DF" modified="2012-07-11" version="1">MAVRKQYKVNINLALCKSCGICYWICPTKTITKGELGRPKVVDHKTCIGCLMCENACPDFAIDVREVEAVKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R4</accession>
    <name>I2F2R4_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Putative deacylase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">Theba_0491</name>
    </gene>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0491"/>
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        <property type="gene ID" value="Theba_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0491"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="OrthoDB" id="632656at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
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        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="397" mass="44963" checksum="E2DEC325B27854BB" modified="2012-07-11" version="1" precursor="true">MKNPLYLKILFLVLSGVLGLLAGIEFWELRHYKETVVVSEDFSEKIMLSQYLPSLKNTWGDTPIYIYDSGVPGGSMLVLGGTHPYEPATTLATYVMMENIDVTSGKVYIIPHANMSASTLGMLGNAYIKYYHIETPWGQKKYRVGDRGTNPLDQWPDPFTYVHYPSTQNLAYQDIRNLNRTFPGRPDGTLTERISYAIMELIRNEDIDIFFDFHEASLMYPVVSTYVAHDRSMDIAMMAAMMLSATQFPMKCEASPKNLRGLTHREVGDFSNTLAILMETPEAFIDRVVGRMSEELMLEGKDEFLQTAAEKGLVYCDYDIYEGFPDALGNMIIGTPMDYRVGRHLSGTLEALNWMNQFFPDKAISVTFPNYVDVMSNGSGYYLHDPSKADPSRVFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S4</accession>
    <name>I2F2S4_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">Theba_0501</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730334.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0501"/>
    <dbReference type="EnsemblBacteria" id="AFK06227">
        <property type="protein sequence ID" value="AFK06227"/>
        <property type="gene ID" value="Theba_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0501"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="303" mass="34751" checksum="78C4AD110A57A04F" modified="2012-07-11" version="1" precursor="true">MRRVFNRGIEHKKARWGWLFVIPSLAFFAVFSFYPIINAFYTSLFRKRLLDLRPPKFIGFANYEYLLKSPDFWNSVKATSIFTLGTFIPIVVFSLLLAVFIMSRRRFQKFFQMVYYSPAVLSSVVAAAIWLLIFDPRGLANTTMNTLLGTVGKDYKWLATAGMVRLSTILVYFWKYIGYFTIIYITGLASIPQSLHEAAQIDGANGWKDFWHITLPLLKPTTVLVSIMSMLQCLKTFSTQYLFTQSGAPTQPINVITLNIYNTAIRDHDIGRASAMSIILFGIMLFFTWLQFRVSKSGGEVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T1</accession>
    <name>I2F2T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730341.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0508"/>
    <dbReference type="EnsemblBacteria" id="AFK06234">
        <property type="protein sequence ID" value="AFK06234"/>
        <property type="gene ID" value="Theba_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0508"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_0"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="425" mass="46566" checksum="29F9E560540202E7" modified="2012-07-11" version="1" precursor="true">MNIDEVIQKYITKGRRTRMLLLTSLEWMLVAGGVMITSLTLPSIVEDLAGTTGSQSMMASSVFVGMLLGALFSGMISDRFGRKWTNLILLLIAGLSTGFTGASVSMRTFSVGRFVAGIGYGGLLPVVNAYLTEFSSIRIRGLYLALLESSWAVGSIITGGFTMLTLNSLGWRWSFYFLALFSVPLLLISFFLPESPKYQFMKKGKVALEKILGKEIDEEIEMHKQSKQPILGLFKGDLARRTIMIWISWFSVSFVYYGIYTWAPKIFMSKGLTPVSSLWYTFFMLIMQLPGYLTAVILIERIGRKPSLTFFFGGMAVSSIVMALVNSSALLLVASVLISLFVLGAWGMVYAYTPELYPTEMRALGNGASGVMARAAGIVAPFFTNLVMGGTGSVFVVMIFMAALSLFAAIIVSKMGVETKQAIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W1</accession>
    <name>I2F2W1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730367.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0541"/>
    <dbReference type="EnsemblBacteria" id="AFK06264">
        <property type="protein sequence ID" value="AFK06264"/>
        <property type="gene ID" value="Theba_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0541"/>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_0_0_0"/>
    <dbReference type="OrthoDB" id="1666267at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="25673" checksum="04B22465A5D727B6" modified="2012-07-11" version="1">MNIDSHCHLLPAVDDGVEEIEESLAILEEMKLKGLQRLYLTPHLFSPISPSDPAEIMRRWHEFRFELNNHSVEVLLGSEIFLRPEVLESDLITMGESNFLLVELSTQQKPHYLFEVIGKLQSTGFRIILAHLERYHYLFKKVGLIFGKVEPTDEIHRLRDMGVLFQVNWNSLDKDSKARVLVDRRIADITGSDKHKQGDNRLLIDFDDDRYRLFLNDSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X0</accession>
    <name>I2F2X0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492182.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0550"/>
    <dbReference type="EnsemblBacteria" id="AFK06273">
        <property type="protein sequence ID" value="AFK06273"/>
        <property type="gene ID" value="Theba_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0550"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_1_0"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="20325" checksum="DAE4144545DD9248" modified="2012-07-11" version="1">MLFDPARIEVLYSEEELKKIVNGLAEKINEYYSPITDEITAVCILKGSVHFYSDLLKRLNLKVRYNFVHVSSYSGASTTGRIRVKTWVDESVTNRYVLLVEDIVDTGGTLRYIINYIWKQKPADVKLVSLFEKTIHDHGVKIDFTGEKIGDQFIVGYGLDYEEVCRNLPYVGYLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y6</accession>
    <name>I2F2Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492202.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0570"/>
    <dbReference type="EnsemblBacteria" id="AFK06289">
        <property type="protein sequence ID" value="AFK06289"/>
        <property type="gene ID" value="Theba_0570"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0570"/>
    <dbReference type="eggNOG" id="ENOG5033Y0Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011229_0_0_0"/>
    <dbReference type="OrthoDB" id="1785043at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="29644" checksum="B0258118ADDD7201" modified="2012-07-11" version="1" precursor="true">MKKLLILIVVFFCVVTVAMNPFQLQTGGNGILAVEYDSGFGSPSDLYGITNSAFSTHFVELTTVASPSSNQRALYLHLFEDSDDGMAGMLQYYMDTENASNVRSLSYTISGALGPFTAYGADFELNMTTATATTYGVSVRGGITGKAYELIEYIVSFSSDLWNSGSSVSSVDLLAGIRFVPDPFMIGLELGTREGMAIKYLGLSTQYTYNNLFSARAGVSMNADLLSNIDFIVGGGMEVRVGDMLITAGIGTNLTNKIESFSFSRNWSVGLLGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F318</accession>
    <name>I2F318_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492246.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0602"/>
    <dbReference type="EnsemblBacteria" id="AFK06321">
        <property type="protein sequence ID" value="AFK06321"/>
        <property type="gene ID" value="Theba_0602"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0602"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_0_0_0"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="79" mass="9083" checksum="EDA0912012C85460" modified="2012-07-11" version="1">MAKYEVTKSVDVRGEVCPVPDVETKRALKKMKSGEILEVWIDYAMSKERIPEAVKSMGHEVLEIEEVGNSEWKIYIKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F321</accession>
    <name>I2F321_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein involved in the oxidation of intracellular sulfur</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492249.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0605"/>
    <dbReference type="EnsemblBacteria" id="AFK06324">
        <property type="protein sequence ID" value="AFK06324"/>
        <property type="gene ID" value="Theba_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0605"/>
    <dbReference type="eggNOG" id="COG2923">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2070287_0_0_0"/>
    <dbReference type="OrthoDB" id="1847984at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017462">
        <property type="entry name" value="Sulphur_relay_TusC/DsrF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38780">
        <property type="entry name" value="PTHR38780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13545" checksum="FA21864BF5E29A24" modified="2012-07-11" version="1">MDKKILFVVYQAPAGSIWVNEAFRTAFGMYGEDIEPSVLLMEEATVALSKKTKPECLGLLSISMCFRFIKRYETAVYGVREHVERFKVKEIEESFNAKLIGEADLGDFFHDFDNVVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F325</accession>
    <name>I2F325_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06328">
        <property type="protein sequence ID" value="AFK06328"/>
        <property type="gene ID" value="Theba_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0609"/>
    <dbReference type="HOGENOM" id="CLU_701719_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="393" mass="43947" checksum="2D49E79FDD6E4201" modified="2012-07-11" version="1">MQDPYKGNGYLLTFRHEIPDAESSGPVSFRKVLFRVQQPPMVSSTRFPSGVIAVSNFKPRSLMINSSLLVQEPSAIENQIEFSKTSSLPNFSTGDYIFDTMKDSLRRVVSVNNSDPSKVTLETEEAFVEEALGTLILNSEGDVSEIIERFGTESDRSFAESVTTNLITKEWEVSMVDEDEIKVAIKNKLVLDANISLDFHLSYDKFSSNGTPRFPTKVSSILEIVGKEGFETEKTKKVAEPEVSISVCGIPVKVSIPIEIFYGLETQIAGIDLQFGPEIEVYPKFHYEVEAKIDFHGPHGKSYTRGSIDHNSTFVHKVDFDGSPEIEGKFGFKFYPGVTIACVLRPEMEIPVGFSAKVNESKAELDFETEGHIMIKLNLLFYKHTFAKTKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F341</accession>
    <name>I2F341_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730422.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06344">
        <property type="protein sequence ID" value="AFK06344"/>
        <property type="gene ID" value="Theba_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0626"/>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068878_4_0_0"/>
    <dbReference type="OrthoDB" id="2005506at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="15483" checksum="C451AD00F786E3DD" modified="2012-07-11" version="1" precursor="true">MIRGVFFAIAAGIVIAMQSVFSARLGEKIGFFGSNFFIHGTGFLLASVLLFFFGKGEMTLESLKGLNPLYYTAGFIGVLIILSISQGVSSLGASRAIVIIVVTQIVFALIISVAGLFGELPIDLTPSKVIGLFLMLSGVLIYQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F358</accession>
    <name>I2F358_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM-linked protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730438.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0644"/>
    <dbReference type="EnsemblBacteria" id="AFK06361">
        <property type="protein sequence ID" value="AFK06361"/>
        <property type="gene ID" value="Theba_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0644"/>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304019_0_0_0"/>
    <dbReference type="OrthoDB" id="1514287at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="24483" checksum="E7468F0466726665" modified="2012-07-11" version="1" precursor="true">MNNNKLVVRFCCGGFLRFLSHQESATAIERTIKRSGLPVAYTQGFHPRIKISFSPALPTGVMSLANYVLLETDGLSQDVVNLLNSVSNFTIRALKAWYLPRDYAKIDDLLDSYRTAIILPKGSYYPERFDASAIVTKKTKSGYKKYNAGDVFMDLSVTSLRTVHVVKYSQPIESMVTAEEILKILSKEGTASYEGVIVFVEDGMLNGRYTSDILDEIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F379</accession>
    <name>I2F379_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0665"/>
    <dbReference type="EnsemblBacteria" id="AFK06382">
        <property type="protein sequence ID" value="AFK06382"/>
        <property type="gene ID" value="Theba_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0665"/>
    <dbReference type="eggNOG" id="ENOG50328DD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564760_0_0_0"/>
    <dbReference type="OrthoDB" id="1159551at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658278" evidence="1">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="483" mass="54384" checksum="6DD2A849F54C1C7D" modified="2012-07-11" version="1" precursor="true">MKSLLVGLLLILSFSGIMAQEIFDFVPEDVGYFLILRGLRSTMEALRDNTNFFGAYLGDNGYGAERAFYGIIDAAGYNAEVDTSFLKSALNNDILLAGEGIDLSLDDLLMFDPFYLLEKLKLTENRVFMAWRTDSSFELLKAVAVLLDMAIFVQPGESVNELRSNTGTLFYNAGDDYLIIGGNKDAVTLALKTYEGEGKRLLESNGKGREVAEMSYDYALAGYIDGDRFHLDLGLESTFSIESTILFARPEGHTLTATIVQDTVFLSSEDLQKMLSVTDTKELEASKETFGDYTVFFPSSSVETLRKELAHWFELDLEPYRELADFVVLLSKESIGNTRIYGDLVSETPRVTAVFTNKSSDTEKFENSLKEWGALQSAHKDSRIYELENDFDTIYFIFSNETTVLTSLSPDEYYRLLSDAESLSDNISYEFVRNLGLEKDIAHAFIDMKKVFKSLMGVSVDSALFYQQTFDENGNMIHALRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F395</accession>
    <name>I2F395_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="8" type="ORF">Theba_0681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0681"/>
    <dbReference type="EnsemblBacteria" id="AFK06398">
        <property type="protein sequence ID" value="AFK06398"/>
        <property type="gene ID" value="Theba_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0681"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="96" mass="11015" checksum="DBB62F9414E4C3C2" modified="2012-07-11" version="1">MKMSRSKKKGPYVHPSLLKKIRELNEKGEKKPIKTWSRASMILPEMIGHTIAVYNGMKHIPVYISENMIGHRLGEFSPTRRFGGHADKKSKKGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A2</accession>
    <name>I2F3A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">Theba_0688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492356.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0688"/>
    <dbReference type="EnsemblBacteria" id="AFK06405">
        <property type="protein sequence ID" value="AFK06405"/>
        <property type="gene ID" value="Theba_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0688"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_0"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="106" mass="12042" checksum="BBE4FAEF066F0356" modified="2012-07-11" version="1">MSRVKKEDTVMIISGKDRGKKGKVLKTFPSEKKIIVEGVNFTKKHQRPTNQYREGGIIERESPIYVSKVMVVCPNCNKPTRVAHKILENGEKVRSCKKCGEIIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L6</accession>
    <name>I2F3L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730571.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0805"/>
    <dbReference type="EnsemblBacteria" id="AFK06519">
        <property type="protein sequence ID" value="AFK06519"/>
        <property type="gene ID" value="Theba_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0805"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039173_0_1_0"/>
    <dbReference type="OrthoDB" id="577287at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="36237" checksum="DF2B2CE58060CCB9" modified="2012-07-11" version="1" precursor="true">MVDVRIEEPEDNFTGNGGPKKSFFWSGLFVLLVIVAIVAVYFLSGFFLVGPDQVGLIKRFGKFTNSVGPGLGYHLPFPIESVVVIDTSNLRKQEIGFRTIRTGTYQTYANESLMLTGDGNIVSVELVVQYYVGDPAKLAFTIVDDGDIVRFTTESVLREEVASSTIDSILTTERDTISIRTAERVQEELDRLDTGIIVKNVFLQEVAPPQQVITAFDDVNSAKQDKEKLIYEAEKYTNDIIPKAEGEAAQIIKDAEGYAQERILNAEGEAERFLEILEEYEKAPDVTRTRMYLETLNKILSEASKTVVLDQSSVLKLLDLEGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M9</accession>
    <name>I2F3M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730578.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0818"/>
    <dbReference type="EnsemblBacteria" id="AFK06532">
        <property type="protein sequence ID" value="AFK06532"/>
        <property type="gene ID" value="Theba_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0818"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018968_0_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="600"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="803" mass="89695" checksum="2FE5AEE6ECACE1E2" modified="2012-07-11" version="1" precursor="true">MTTSSTKIISKILLYVVIVGGAFLMLIPFAWMVATSFKAPSEVSTWPPVWTTKNAASSFTFKTQIKQKSASASVDLSALSLSEFRNFAALMEESASFDTVTVNLDDDPIRRGEIEIQLLETNGSPADYSTEVDRQRFESLIERYHTLATNFPDSVSRDLKDLPVDDVGRFLDSFFNVAVYGDNGFVRRVILVTSLKTEYSKAIERLAQSVETAMKELPIDTDESKAIKKRIREESARLFENPVAELTRSIENLEPYRTGSTGVTDLTELEKVVEDLRDSINTIRNVASEVVTLSQEISAGDSRVSISVRQIERSLEAVPSGLIQWMDLLNLYSDLRIFYDESQNESLSSASIVGKIRTDSEVHSLLSDFVNRWDIDEEMRTHLLTKVNPSNVRNAVAILLNYLDSNFKESLSKYFSDVQTPLEAINDAMNFLRTSLLVASDPVLDEKVNSAMDEETPYSSLITLIKEVASAAGQTIGVGGVVASLDRQANISGHEPFAELIRRRWRETDLIGTFSRVHSDIFSELDLSSKPDEVERVYYRGIISPSGAKSFDIKLKGIPAVWLKDDQCAGKANFTLGETISNFFQNYVTAWNAAPFGRYYFNTVFVATVTTFVEIIFAAMAAFAFAKMEFFGKNLLFTLFLATMMVPGEVLLVPNYITLTALGWIDSYYALIVPWVVSVFAIFLLRQHFMTIPNELYDAAMIDGLSKWRFLWTILVPLSKPAVITAALLKFVGSWNSFLWVLIVTKSPEIRTLPVGLQNFSSATGSDYHLLMAAATFSIIPVVILFLITQKYFIAGIARSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N4</accession>
    <name>I2F3N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730582.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0823"/>
    <dbReference type="EnsemblBacteria" id="AFK06537">
        <property type="protein sequence ID" value="AFK06537"/>
        <property type="gene ID" value="Theba_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0823"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860340_0_0_0"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="337" mass="38297" checksum="E5462E9B2E784A5F" modified="2012-07-11" version="1" precursor="true">MKRLLSVILVILTTGMLFSATLLFPLKRAPEITGYFGEFRGNSKNINYPEHFHMGMDYSTGSIVGLDLRSPDDSYVHQIYINHPIYGIGIALTLPEVTNILTNEEGINVIFAHVNEVGDTSTLTGRKLNDLYHQLISEFGDQYVEVTFDPRELLFRKSDVVAKSGNSGNVPPHLHLEVRDSTMQTIINPGFFFDTGSPTPAIEILDIRAGGKTYSFSEGKPTIEMTPNTPLDLHAKVQLRHPISPKTIELYVENSLIYQIDFVSFELDEVDKVREIYSSPSTESDYWFNLNSRISLSVLPINIWDDIDWTNPRDARVVVRDHWGNEASKDFRIEMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T7</accession>
    <name>I2F3T7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyQ</name>
        <name evidence="9" type="ORF">Theba_0880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730628.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0880"/>
    <dbReference type="EnsemblBacteria" id="AFK06590">
        <property type="protein sequence ID" value="AFK06590"/>
        <property type="gene ID" value="Theba_0880"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0880"/>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057066_1_0_0"/>
    <dbReference type="OrthoDB" id="676868at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="284" mass="33319" checksum="180DF8C341C7D922" modified="2012-07-11" version="1">MYLQDVVEKLNSYWSMQGCIIDQPYDLEMGAGTFHPSTFLRSLGKKPWKVAFIQPSRRPTDGRYGENPMRVQRYFQYQVIIKPNPENSQELYLGSLEALGINPKEHDIRFVEDNWESPTLGAWGVGWEVWLDGMEVSQFTYFQQVGGIDVDLVSLEITYGLERITMYLQKKANIFDIDWNEEFKYGDVFLENEKEFSAYNFDVADTSRLFELYRFYREEFDLCMEHGLVRPSYDYMIKCSHAFNLLDARNAISVSQRQSYIKSIREMAKAVAEAYVAKERDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X5</accession>
    <name>I2F3X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation/cationic drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730651.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0922"/>
    <dbReference type="EnsemblBacteria" id="AFK06628">
        <property type="protein sequence ID" value="AFK06628"/>
        <property type="gene ID" value="Theba_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0922"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131462_4_1_0"/>
    <dbReference type="OrthoDB" id="1944417at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="123" mass="13098" checksum="9B789B1998FCAFD9" modified="2012-07-11" version="1" precursor="true">MNITEGIVLLVAIVFNAGANILLKHGMQNAPDINSVGLKGMLVNSITNISVWLGLLSFGVAFIFYSVVLTRMKLGVAYPIMTSAGFAIVTVVAVFLFDERLSVMKIVGIAVIALGIWLVAMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F421</accession>
    <name>I2F421_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492698.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0968"/>
    <dbReference type="EnsemblBacteria" id="AFK06674">
        <property type="protein sequence ID" value="AFK06674"/>
        <property type="gene ID" value="Theba_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0968"/>
    <dbReference type="HOGENOM" id="CLU_2023967_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658629" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="13517" checksum="470441D00C6E9CCC" modified="2012-07-11" version="1" precursor="true">MKKVLILVAVLLVASVFVAAPKNFILGQGLYGDVVYDLAGNITGYEGMDFYIFQASTYYEKALTPGELNAYTFDGKFLFFIPVFGRGWEFVLRPVDNIILTAGLSLLYNFLPGPYLGLTILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F453</accession>
    <name>I2F453_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PK_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492738.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1000"/>
    <dbReference type="EnsemblBacteria" id="AFK06706">
        <property type="protein sequence ID" value="AFK06706"/>
        <property type="gene ID" value="Theba_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1000"/>
    <dbReference type="eggNOG" id="COG1751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095207_1_0_0"/>
    <dbReference type="OrthoDB" id="1573084at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PK_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="186" mass="20374" checksum="0F2BD0EC60815E9E" modified="2012-07-11" version="1">MTMYFSKSDEETTKTLLARIFERAEEKNIDKVILPSTSGVVARMAFDLVPDSVRLIIVTHSVGFREPDEDEFDPQVRKLYSGSRHSLLTVTHLFRGIEVAFAKANGGVYPLQIFATALRLFGQGTKVAVEIAIMAADAGIVRTDQWVISAGGTNHGIDTAFVLKPCHSTDLSIFKFGELIGIPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F469</accession>
    <name>I2F469_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of uncharacterized ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730732.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1017"/>
    <dbReference type="EnsemblBacteria" id="AFK06722">
        <property type="protein sequence ID" value="AFK06722"/>
        <property type="gene ID" value="Theba_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1017"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="258"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="508" mass="55921" checksum="4B8F67F3520A22BD" modified="2012-07-11" version="1" precursor="true">MADLPILEMRNITKAFPGVIANENISLDLKKGEVHALLGENGAGKTTLMNILFGIYKADEGEIFMEGKQISISSPHNALKYGIGMVQQHFTVVPSFTVAENIVLGLKGMGFFIKTKTVESSIEKLGKSYDLPVNPRARVWTLSVGEKQRIEILKLLYTGAKVIILDEPTAVLTPQETEILFKAMRKLVNEGSSVIFISHKLDEVLEISDRVTVLRGGKVVGTEVRDSVDRRSLVRMMVGRDVLLDFDKPKTEPGKTVLQVENLTVKNDKNLEAVKNLSLSIKSGEILGIAGVAGNGQRELAEAIYGLRKPVQGKVVLNDKILRHTDVAQRIKGGVAFIPQDRRAVATCPSLSITENVFMKNSYSMYLPQSPFNLNTRAMQRAAKELISDYSISTPSTKTQARFLSGGNLQKLVLARELSTKPCLIIAEHPTRGLDIGAMEFVYKTLLAHKERGAAILLLAGELYEIFRLSDRVAVIYEGEIMGYTPPDPSFTEEIGFMMAGSKRGEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F473</accession>
    <name>I2F473_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730736.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06726">
        <property type="protein sequence ID" value="AFK06726"/>
        <property type="gene ID" value="Theba_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1021"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_15_0_0"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="286" mass="32525" checksum="985F4C6D413913AC" modified="2012-07-11" version="1">MEGYVTVPGGRIWYEVQGRYSKMKPFITIHGGPGVPHNYLETISALSDERPVVFYDQLGCGRSERPSDRSLWRVDRFVEEIECLRKELGFSTIHLLGQSWGTILACEYSVKYPSFVESLVLSGPAMSITRFESDARKLVETLSDHSQSAIKRAESIGNFNGESYHSAISEFYGKYVCRVKPWPQCMKEAVAGMGEEVYNYMYGPSEFTVTGVLKDFDCTPHLENITVPVLLTCGEFDEATPETTRYYSSKFPNATMRIFEGASHEHHLEKAKEYIEAVRRFLKDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F495</accession>
    <name>I2F495_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">Theba_1043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730754.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1043"/>
    <dbReference type="EnsemblBacteria" id="AFK06748">
        <property type="protein sequence ID" value="AFK06748"/>
        <property type="gene ID" value="Theba_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1043"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_0"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
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        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="355"/>
        </location>
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        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
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            <begin position="55"/>
            <end position="59"/>
        </location>
        <ligand>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="441" mass="49284" checksum="0C1C6025998E86AA" modified="2012-07-11" version="1" precursor="true">MATVLIIGRPNVGKSTLFNRLVGGRRAIVDDLPGVTRDFTVGRVNWQQRTFQLVDTCGLFENPENIVEEKMKEVTLELLSEGDLILFVVDGRFGLTSADQVLADYLRKQRIEVIFVANKVENPESFYSNMGNEIFSLGFGDPIKISAAHGLNIDLLLDEIFERLETLGHSVHLESNDESELKIAIVGKPNAGKSSIFNWIVGSPRSLVTEVSGTTRDTVDETVEVDGIPITFIDTAGIRKKSKVKVMNVEYYSVMRAIDALERSDIMVMVIDSADGVGNQDQRIAGLAEKNGKATIAVFNKCDLVDERRRKALLRTFKQDLYFIDYSPVIFTSTLTGEGMDELIDSIKLVSKKIDLRLPTGLLNTILQRYSEGTPAPGKGKKRGKIYYGSQIASRPPIIMLNVNDPSLFSEPYLRGIRNTIRLNFDPFEGTPIFLKLRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C0</accession>
    <name>I2F4C0_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the UPF0473 family.</text>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="134" mass="16071" checksum="49CBCCB8799FC734" modified="2012-07-11" version="1">MEEKKELEFHVSEECNDPNCDHDHDLVSDVDRFTVTDEDGSEHHFTVIAEFENNDNTYWVVEEFFEEDDEEADEEEDDASEDEEEEGYIVFRVEYDENENPYLYSVEDEEFEEVSKAWNKLVEEMIAEDDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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    <name>I2F4D6_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
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        <name evidence="6" type="ORF">Theba_1084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="Theba_1084"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="Oligopep_ABC_C"/>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="oligo_HPY"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK06789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="320" mass="35453" checksum="82B6570B60F77BFD" modified="2012-07-11" version="1">MKLLEIRNLTKRFPIEDSIFGKPVKFLKAVDDVSFEVDKGGVFSLVGESGSGKSTIARLICGAYQPSSGEILYKGNPIGRTKTDYRNIQMIFQDPDASLNPRKNVFSIIEEGLRIHRLGNLRERREKVLTILDSVGLDRSTIKKFPHELSGGQKQRVSVARSLILQPELLVLDEPTSALDVSVQAQMLNLLGDLQKEFLLTYVFITHDLKIVSQISDHVAVLYLGNIMEIGPVDRIIDNPLHPYTQGLLESVPQPDPSKKAANEILMGEIPSPVNPPKGCPFITRCPKAFEACAIKPELKVVGDRKVRCHLYDTGGNSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E9</accession>
    <name>I2F4E9_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_1097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730799.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1097"/>
    <dbReference type="EnsemblBacteria" id="AFK06802">
        <property type="protein sequence ID" value="AFK06802"/>
        <property type="gene ID" value="Theba_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1097"/>
    <dbReference type="HOGENOM" id="CLU_129275_0_0_0"/>
    <dbReference type="OrthoDB" id="2039235at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="160" mass="17593" checksum="42B5D7D5A6FB2925" modified="2012-07-11" version="1" precursor="true">MMNRDTIIRIIIGAIMVLLGIFTIFVKSFTLNLWLLLIWIPAVFMEYRAFSGRDRNLFVPAGVLITIAVILSLNVIFPGFITEGGWALFIAAPAVGLFQSYFGREEKDKGVLTAASFLSALSILFLLISVAPTVLGIFIGIVLLGVGGLVVYKNLRTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H1</accession>
    <name>I2F4H1_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06824.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1119"/>
    <dbReference type="EnsemblBacteria" id="AFK06824">
        <property type="protein sequence ID" value="AFK06824"/>
        <property type="gene ID" value="Theba_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1119"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="161" mass="18347" checksum="ABC74C5D214CC0CC" modified="2012-07-11" version="1">MTVRTKELGPDKILEAVFDLVRNFTKFFSLNVEAEEMKTIELYILLFVALKGPQSMSSLAKEYSMTKSNVTVLVDDMESKGYLARIRSEEDRRVIMITLTERGKAFFESFLKNFSRLISTFIRKVGAEDLAIITDGFERITRIVIDEELVSSDEGGKPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H7</accession>
    <name>I2F4H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730824.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06830">
        <property type="protein sequence ID" value="AFK06830"/>
        <property type="gene ID" value="Theba_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1126"/>
    <dbReference type="HOGENOM" id="CLU_378907_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="731" mass="84156" checksum="3D03FD8A997EF27E" modified="2012-07-11" version="1">MDRETAKVTLLAEALEMSRNSYVEHRTLEGLESFFDRSTAIELAKGLKDGFSLEIPLEVIMSNGFFRGYLAGLMLSDKTTSHVVKEQIAKILLEDLLRTMNEAEETSPRQEESFQSEGDLKKRFFSLFEEKDREESGGLVRENLSLFRHFMNSKHFIPIYLWGNELTTFICESLDSEQFEGSLREDLRKIVPFVLASYSMPDTMGSSVGLRLPSIESYLSSQFPILAMIRNRKLNPDQVTEFIKSLSHIIFGDILLAPVSMAAGGKTEEKARAKLIINKMFASMSDSELGIMLNSSGYESRDGFLYEVVVCNDFSKLFDRLKNILKGIEKKASLFSNMAIASALLDKDEAIDYVVEYVAYLKALEPTIAVVRSGLLLCMKYDLEDEEFFRKKFFEITDEKPDPPLIRSLLRDSFGDLDVIYEHMADEYSYRTAIDGVISNLKSIKEPNFISFEKTGSLEYSRVPMYTLINSAISQNDIDHAFDTLVAYCKKYRFNFEFMNTLLFLSTRETDELKKLLRVEGELALKVLHDIVEKDRWASLIEVEQSPSNTELLQVIEHYVDSLIDRKDYREALRVIEEVFPLVGPDDYGYLLASKLLVCWRLNMFDELAKTMESKNHSGHPKALAVLALKNYAYRELDRAEQILLKILHQCPDFIKYLLEEEENDKKDFEKAERGNLRSQKRVDSLTLAEEFRGDWLNLRGGKEWLKRVQKVFDELRDGSNLPENFDSSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I9</accession>
    <name>I2F4I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730833.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1138"/>
    <dbReference type="EnsemblBacteria" id="AFK06842">
        <property type="protein sequence ID" value="AFK06842"/>
        <property type="gene ID" value="Theba_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1138"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046693_2_0_0"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="47"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="49816" checksum="EBEF153015050704" modified="2012-07-11" version="1">MLVSFAIENFRSFLDETVFSMECESVSELQELNTFVSGKWCLLKSSFIYGKNAGGKSNLLKGIAKMRDILLHSFDDSYRLQTDRFAFKEGAEKRPTKFEIEFLTEYSGGPRKFRYGFEIQGDKIYSEWLFITHERETRIFSRESASKKDIVITKKYGELKKFVEFTNPNVLFLSVINKIGSVDLVKTVFDYFLSMIIIDASRFPTSLTAARLYEDKTLYEKTVNFMREADQGISGLEIRREEFEDVEAYFKDITGRRNDLEIDITQVHDGRDGSKKFLSYDVFTSHEMYNADRSMKAKILCDLRDFESEGTKKFFKILGPVVDALTHGKVILIDEIDSKLHPLLVEALIDKFNSISENSKNAQMICNTHNPLILESKKVRRDQFWFVDKNELGESSLYRLTDFTNVRKDLNLKKAYLLGQFDGIPKMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K3</accession>
    <name>I2F4K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486464.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06856">
        <property type="protein sequence ID" value="AFK06856"/>
        <property type="gene ID" value="Theba_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1157"/>
    <dbReference type="HOGENOM" id="CLU_153045_4_1_0"/>
    <dbReference type="OrthoDB" id="1820646at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="82" mass="9255" checksum="1C3329927E8F5588" modified="2012-07-11" version="1">MSIGVKSIKSCKPYQLILEFSNGEERAIDLEGILNKGKFSELRDPKVFCSACISFDTIQWSNGLDICPEYLFDHSRPIAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L0</accession>
    <name>I2F4L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endonuclease containing a URI domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730852.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1165"/>
    <dbReference type="EnsemblBacteria" id="AFK06863">
        <property type="protein sequence ID" value="AFK06863"/>
        <property type="gene ID" value="Theba_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1165"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_3_1_0"/>
    <dbReference type="OrthoDB" id="2077602at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="99" mass="12347" checksum="6E691B73BF4A35D3" modified="2012-07-11" version="1">MNSGFVYIMTNPSRNVFYIGVTNNLFRRVFEHKNKMIEGFTHKYNCVVVVYYEYFETIKEAIRREKQLKSWKREWKLRLIKTRNPDLRDLWEDIRESYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q0</accession>
    <name>I2F4Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC-type transport system, periplasmic component/surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730890.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1206"/>
    <dbReference type="EnsemblBacteria" id="AFK06903">
        <property type="protein sequence ID" value="AFK06903"/>
        <property type="gene ID" value="Theba_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1206"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_1_0"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="2">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="35510" checksum="39EB7AD124D270FA" modified="2012-07-11" version="1" precursor="true">MRRAILLFSLLLAVTFAASKFSVGILITGEIGGNAIYELVQKGALEMASEEIEIKIVEGGYNQSKWEQMLISLAALGRYDLLMTFTEGMPASVNKVAEMFPNQKFALLDGIIENPLPNTYSVAFKDDEMTFLAGIFAALITSSSLPGANEEKVVGLIAGDTYPAMTNVMRPSFENGVKTVDPSIRVFFGVVGSWSDPARGSELAAKQFDAGADVILSIAGGSGIGVIEEASVRGKYVITVDSNMISMNPSVILGSFLKHIDVLVKNTIADAKAGTLPFGTSKRVGIAEGMIDYTHDDPNFVRNVPDDIRAQLAEWFEKIKAEGLPKINNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R9</accession>
    <name>I2F4R9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">Theba_1234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486566.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1234"/>
    <dbReference type="EnsemblBacteria" id="AFK06922">
        <property type="protein sequence ID" value="AFK06922"/>
        <property type="gene ID" value="Theba_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1234"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_1_2_0"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="107" mass="12092" checksum="FB08F23B1680F30A" modified="2012-07-11" version="1">MYAIIEASGRQYRVEEGMTLFTERQNGKESGDEIVFDRVILVHNGEEATVGKPYVNGAKVVGKVVSHGRDKKVLVVKFGPRKNFDRVNGHRQWFTEVSIEKIETGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F519</accession>
    <name>I2F519_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486742.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1334"/>
    <dbReference type="EnsemblBacteria" id="AFK07022">
        <property type="protein sequence ID" value="AFK07022"/>
        <property type="gene ID" value="Theba_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1334"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_2_0_0"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="33946" checksum="1CB8802A5E71573F" modified="2012-07-11" version="1">MPEIYGTVYGVEFHPVGKLYQYTSSEGLLKQGDYVLAISEFGLDVGKVMYGPVEIRIDDSKEELKPIVRVMTDEDWETDSKNKEEAKEAMKTCQELIEKHSLPMRLLEARYMFDRSRIVFYFGADSRVDFRELVKDLARAFRTRIELRQVGIRDEVKMKGSLGLCGMTACCVRFLRQFESITLKHAKKQQLLINPAKISGRCGRLLCCLSYEQELYENELKDIPDEGSLVDYEGKTCKVLTVNIFMKIITLVSDDGQMLKVQFEDFRKSQRAIIQDTNPDELIKNRDEDISIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F534</accession>
    <name>I2F534_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">Theba_1349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486768.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1349"/>
    <dbReference type="EnsemblBacteria" id="AFK07037">
        <property type="protein sequence ID" value="AFK07037"/>
        <property type="gene ID" value="Theba_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1349"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_0_0_0"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="254"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="376" mass="41830" checksum="AF6107A050DCCE8F" modified="2012-07-11" version="1" precursor="true">MKKRLAILGSTGSIGSQTLQIANRIENIEIVAISCGHNLSLFSKQLSEFHPPFAASLKKSDSLTDSFPATLFFHGEEGIERMLEESKPDYVLLAVSGAAGLRFSLKAIEVCHRLCLANKESIVCGGDLLLKECARKGVELIPVDSEHSGLFQLLDGSRRPKRIIITASGGALRDWPLERIQDATIRDVLRHPVWSMGNRITIDSASMVNKGLEVIEAKYLFEFETNEIDTYICRNSFIHAGILYSDGVLKLHTGIPDMRIPIAYSLTYPERIQTIPEQSIVDVPMILEELPKERFPALTLAREICGVVSKQIAYNAADEVAVEAFMNGRMPFGGIYNIIEKTVERTADQNPVDYSQIIETDSVARKLAQEEVDRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F563</accession>
    <name>I2F563_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731012.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1378"/>
    <dbReference type="EnsemblBacteria" id="AFK07066">
        <property type="protein sequence ID" value="AFK07066"/>
        <property type="gene ID" value="Theba_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1378"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_3_0"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="74" mass="8325" checksum="9A5218851CADE21A" modified="2012-07-11" version="1">MSKNFVKIDEERCKGCGLCINFCPKKVLSFSDKFNSKGYRPAQLHDLENCIGCGFCYMMCPDAAITVFKETAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F585</accession>
    <name>I2F585_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1400"/>
    <dbReference type="EnsemblBacteria" id="AFK07088">
        <property type="protein sequence ID" value="AFK07088"/>
        <property type="gene ID" value="Theba_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1400"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="26099" checksum="9DC1F899351DA74B" modified="2012-07-11" version="1">MSILKLDKVTKRFGGLVAVDNVSMEIQQGEILGLIGPNGAGKTTLTNLISGVHMVSEGKIIFDGIDITFLPAHKRCNLGIARTFQIARPLKNLTVVENIMVGGLFGNGEKLKESKKSALRLCETIGLEEPDQTLDKITVLDIKKIEIARAMATKPKILFLDEVMSGLNMDETREMIDTVRKIRGTGVTICIIEHVMSVIREITERVIVLDRGTILAEGPYSEVSQQHNVITAYLGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D0</accession>
    <name>I2F5D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein PhzF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731074.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1447"/>
    <dbReference type="EnsemblBacteria" id="AFK07133">
        <property type="protein sequence ID" value="AFK07133"/>
        <property type="gene ID" value="Theba_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1447"/>
    <dbReference type="eggNOG" id="COG0384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_2_0_0"/>
    <dbReference type="OrthoDB" id="1468060at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="267" mass="30142" checksum="E7A5E3E50D6C7144" modified="2012-07-11" version="1">MHYIYQVDSFTAVPFSGNPAGVCVLEGQIDENLCLKISSEMNLSETAFVWPEGTSNTFNLKWFTPKTEVKMCGHATLATAWIQFTELGIKGEIFYETLSGRLKVKLVDEMIEMDFPSEDPVRIDLDRRIGEIIGIEGNAYYSPGTEKLLYEIPVKDELETLSFDTKRLLKTDFGKQSKGLIVTCSGDERYDFYSRYFAPWVGIDEDPVTGSAHTVLGLFWAKKLNKKKLKACQLSARKGELETELLDDRRILIRGKAVTVIRGVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J4</accession>
    <name>I2F5J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative multitransmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731118.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1517"/>
    <dbReference type="EnsemblBacteria" id="AFK07197">
        <property type="protein sequence ID" value="AFK07197"/>
        <property type="gene ID" value="Theba_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1517"/>
    <dbReference type="eggNOG" id="COG5438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028166_4_0_0"/>
    <dbReference type="OrthoDB" id="1746642at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="374" mass="40251" checksum="7A71B4E8E75D24FE" modified="2012-07-11" version="1" precursor="true">MSMKNVFLYVIGAVVFGYVVFTFIDASANDQSTIKGRVIEMISFDETGGYSAKGLQTLRVKVLTGTYAGEEVVIENHFTDNPAMDIRVEKGDTVVLYMDERDEVTFHIIDFVRQRYVFVIVLVFICLLLLIGRISGLKSFITLTLTGLIVIKVMLPLILKGFNPIGASSLSAAVITILTFAIVAGVNTKSLSAIFGTLCGVLSASLIAYVTGSLANLTGLSSDEATMLVYIPQNIEFDFMGLLFAGIIIGTLGAVMDVAMSISSAMYEMKSINPEMTTGKLVKSGFNIGRDIMGTMTNTLILAYTGSSIFLMLVFLAYETTVIRIINMDVIATEIIRAVSGSIGIILSIPATVLLSAFLLNKYGVRSGSTAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L0</accession>
    <name>I2F5L0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487134.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1537"/>
    <dbReference type="EnsemblBacteria" id="AFK07213">
        <property type="protein sequence ID" value="AFK07213"/>
        <property type="gene ID" value="Theba_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1537"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107893_1_0_0"/>
    <dbReference type="OrthoDB" id="1100576at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="213" mass="23635" checksum="A2D8C6023AC72FD6" modified="2012-07-11" version="1">MRNSLRRWKNEKLSERLAKVFESKAIKFMYFPDKEMVVDAVSKLVPDEATVSAGGSLTLQETGVSDLLKSGKYNFLDRDSVSGNEEKKRIMISAFEADYYFCSANAITESGEILLLDGNGNRAAAVTFGPDKVILIAGVNKVVSDLDAGIKRIRSIAPMNAKRLNLHTPCAESGLCTDCDSDERICEIYSIIVDSRRRPWRYTVILVGEELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M2</accession>
    <name>I2F5M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleotide kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFK07225">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03266">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="172" mass="19711" checksum="461635A3F4FDAC96" modified="2012-07-11" version="1">MKFFITGERNVGKSYLVERIKPVVKYRGFETRFDNDLENLYMNFYEGDSLLIGTRERGRLRIVEEGFLFATKLLGSLDIPNDNLLIMDEIGFLEEDSPEFQQAVVSSLRRAKHCLCVLRKGNFSFIDHLKRSMGIGSIELTEANREDVFGRVVREIEKERANLPSPGGDEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N2</accession>
    <name>I2F5N2_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1563"/>
    <dbReference type="EnsemblBacteria" id="AFK07235">
        <property type="protein sequence ID" value="AFK07235"/>
        <property type="gene ID" value="Theba_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1563"/>
    <dbReference type="HOGENOM" id="CLU_3009051_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="56" mass="6392" checksum="AA6DE3F9FFB8853F" modified="2012-07-11" version="1" precursor="true">MFSSFSIKGTTEIVIAVFTIVPVESILLRKREVSAARYLRAKFRRRVNCVQKNCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q0</accession>
    <name>I2F5Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731159.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1583"/>
    <dbReference type="EnsemblBacteria" id="AFK07253">
        <property type="protein sequence ID" value="AFK07253"/>
        <property type="gene ID" value="Theba_1583"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1583"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035564_0_0_0"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="419" mass="47030" checksum="255F100A5CE09A20" modified="2012-07-11" version="1">MEIKRDGQFYRFAAYGFLKNLRFFDPFLILFFREMGLSFLQIGTLVSVREVATNFLELPTGIFADLFGRRLSMVFSMISYLSSFLVFYFFPNFYIYMVAMIAFAFGEAFRTGTHKAMILEYLRINDMTDIKVHYYGATRAASQLGSAINALIAAFLVFYTGSYKIVFLASVLPYAVNLVNLMMYPKELDGELKSGEKRETLKAFLGIFRSANALKGVLNSSLYDAFFKVIKEYLQPILKALALGLPIMLAFSPEQRTSVIVGVVYFVIFIATSYASKNAGRLSKKLGNEARSLNYSYIFGAILVILSGLFQIVSLQVIAVIVFFLLYILENFRRPINISYISDNIDHKTMASGLSVESQLKTLLVAIIAPIVGFLADKLGVGMALTVAGMTMLVLFFIVKLNPPENTKNIEEKNSRTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q8</accession>
    <name>I2F5Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489374.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1593"/>
    <dbReference type="EnsemblBacteria" id="AFK07261">
        <property type="protein sequence ID" value="AFK07261"/>
        <property type="gene ID" value="Theba_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1593"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="292" mass="33066" checksum="D71794F9AF284379" modified="2012-07-11" version="1" precursor="true">MNRKTRERLVGYSFIAPDITGLIIFAMVPAIVALVISFFSWNGLSDMLFVGLDNYRTMFQDPQWRNSIFVTLKYSVFFVPMNFLFALLLAMLVQKPGPGIGLFRAIFFAPTAMSMVAVSFVWKYMFQPYGFVNYFLSFFGITRQPLLGSMSQALYCITVVSLYMSVGYYMVIFLAGLNEISNEYYEAAEIDGASGFQKFLYITLPLLKPTTAFVLVMTFLQSFQVFDQIYILTGGGPFYSTSTAAFYIYYNAFQMYQFGYSSAQAFTLFAILLVVSYFMLRALRGGNVSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S9</accession>
    <name>I2F5S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ORF">Theba_1618</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731181.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1618"/>
    <dbReference type="EnsemblBacteria" id="AFK07282">
        <property type="protein sequence ID" value="AFK07282"/>
        <property type="gene ID" value="Theba_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1618"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
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    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
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    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="327" mass="38105" checksum="7C08105B8994D921" modified="2012-07-11" version="1">MKKNFYLFASGQLSRKDNTLLLEREGRRKFIPIEKIESISTFGEIDLNTHLLSFLSKKEVALHVFSHNGWYSGSFVPRKQKVSGKLLVEQIKTFLDPIKRLKLSREFIDGAMHNMLRVLQRSSSKIPGYKDKIEGLKNTRERLQNTTGVNSVMAVEGAFRQYYYPILAGLTGQEFVTRIRQPPLGILNCMISFGNSLLYTRTLSKIYQTQLDPTVSFLHEPCEMRFSLCLDISEVFKPVIVDRLIMTLLNKAIITEDDFDKEMNSTLLTNEGMKKYVEHFEKFMEETVFHPTLKRKVSYNTLLLTECYKLIRSILSEEDYKALHMWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T6</accession>
    <name>I2F5T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1625"/>
    <dbReference type="EnsemblBacteria" id="AFK07289">
        <property type="protein sequence ID" value="AFK07289"/>
        <property type="gene ID" value="Theba_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1625"/>
    <dbReference type="HOGENOM" id="CLU_3137543_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="49" mass="5395" checksum="6253FE0D82E4FA46" modified="2012-07-11" version="1" precursor="true">MKPNELGAPRNPTNIAQAIMLVVKVGLEVFDAACHIAVQYKKTKEELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X9</accession>
    <name>I2F5X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07332">
        <property type="protein sequence ID" value="AFK07332"/>
        <property type="gene ID" value="Theba_1670"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1670"/>
    <dbReference type="HOGENOM" id="CLU_2666863_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="75" mass="7994" checksum="55E3874BB92E78C0" modified="2012-07-11" version="1" precursor="true">MKTRPPEVPSILEMLLLAGSILRSTVKGSPSSEETKSRSDAAFSGKHSEAGQKARIIAASEGFAFASTTSREKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Z8</accession>
    <name>I2F5Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1691</name>
        <name evidence="3" type="ORF">Theba_1758</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="2">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731245.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1691"/>
    <dbReference type="EnsemblBacteria" id="AFK07351">
        <property type="protein sequence ID" value="AFK07351"/>
        <property type="gene ID" value="Theba_1691"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07414">
        <property type="protein sequence ID" value="AFK07414"/>
        <property type="gene ID" value="Theba_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1691"/>
    <dbReference type="KEGG" id="mpg:Theba_1758"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_6_0"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="145" mass="16230" checksum="BB6513CA9CB6FB8C" modified="2012-07-11" version="1">MIFDDKIGSLFEKIASLHINLSRHARLALEPHGITYPQFGALLVLSSRGEMTQKQLSSHLETDTTNTMVICVGLEKKQLITREQSSEDKRANIVSITAKGREIFQKSMAVLRESYGPTANSISEKKRDTVNSVLDKLLESLNTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I2F668</accession>
    <name>I2F668_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1698</name>
        <name evidence="2" type="ORF">Theba_1765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
            <strain evidence="2">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731252.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07358">
        <property type="protein sequence ID" value="AFK07358"/>
        <property type="gene ID" value="Theba_1698"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07421">
        <property type="protein sequence ID" value="AFK07421"/>
        <property type="gene ID" value="Theba_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1698"/>
    <dbReference type="KEGG" id="mpg:Theba_1765"/>
    <dbReference type="HOGENOM" id="CLU_1633450_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="162" mass="17546" checksum="02DC1A1DDA4CE24E" modified="2012-07-11" version="1">MTGCDVFEKADNCHPELVSGSALLKTASGSEVGKANETGLPFNGSPFSEENLFFVPERGSVLHALSKDGFMVLDEGPTVALYSAQRVFTLKRTAILRIEMLKQVQMTPRKGFRLQDRGLVNRTGLPIQGFAANEVVIQTAVLGSPSNCHPELVSGSGRRPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F671</accession>
    <name>I2F671_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1702</name>
        <name evidence="2" type="ORF">Theba_1769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MesG1.Ag.4.2</strain>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731255.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1702"/>
    <dbReference type="EnsemblBacteria" id="AFK07361">
        <property type="protein sequence ID" value="AFK07361"/>
        <property type="gene ID" value="Theba_1702"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07424">
        <property type="protein sequence ID" value="AFK07424"/>
        <property type="gene ID" value="Theba_1769"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1702"/>
    <dbReference type="KEGG" id="mpg:Theba_1769"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_0"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="253" mass="27586" checksum="5F290AD525F733A7" modified="2012-07-11" version="1" precursor="true">MSERLTGKTALIFGAGRVGSSAANAFVNEGAKVILLDRDEERLEALKKKLEESRKGFCSTICANIDSQRDVNEISDLLEEKTWKVDILFNCPAYIYRAPFVDHPIEEIDKQWHVNVRIVFMLSQVVAKMMSKNGGGKIINLASVGGLFPEKEHAGHCAAKAGIIAISKVMALELASANIQVNVIAPGPTETVPFTSPFYSQHPEVLKRIEEKTPAGRIGHPEDHTGLMVFLASDESNWITGQVIMSDGGLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F697</accession>
    <name>I2F697_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative subunit of the multisubunit Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731281.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1799"/>
    <dbReference type="EnsemblBacteria" id="AFK07450">
        <property type="protein sequence ID" value="AFK07450"/>
        <property type="gene ID" value="Theba_1799"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1799"/>
    <dbReference type="eggNOG" id="COG1563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173139_2_0_0"/>
    <dbReference type="OrthoDB" id="2088292at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="80" mass="8468" checksum="D0D4CDFAF160C7D9" modified="2012-07-11" version="1" precursor="true">MNVFSFIIGVVMVGLAIFAIEANKLLTSVIMLSAMGLLSVILFVIMKAPDVAITEASVGAGLTTAIFLLSLRKLKRADVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L6</accession>
    <name>I2F6L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1922"/>
    <dbReference type="EnsemblBacteria" id="AFK07569">
        <property type="protein sequence ID" value="AFK07569"/>
        <property type="gene ID" value="Theba_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1922"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914682_0_0_0"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="304" mass="35430" checksum="96AFCCE6E027E4EA" modified="2012-07-11" version="1">MKDFYVDKPSFEESRRIMEKMYHSIPESSNGRYSLSELRPIEEVYFDFFKRGDKLLVLRGQGEIIGHIHFGPQRDERFSSNLSGHIYDLYVKKGYRGEGAGRTLLRSALEEVKPIFQTITANTYRFGAGWHMLKSEGFNEKRITFSTDKRLSHSRINAFEIFRGLPDDLGKVFVEISSSPTIVKRQLQMTPSELFFNLNEIMDSGGRILICRQDEETAGVLIYSVFEDLMTYSLLGFIEFVFVSERFRRMGIGRNLLSFLSEYLLIRGVEESFFECVFESDYHFWSRAIGMKEFSVLLEKKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L8</accession>
    <name>I2F6L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731373.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07571">
        <property type="protein sequence ID" value="AFK07571"/>
        <property type="gene ID" value="Theba_1924"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1924"/>
    <dbReference type="eggNOG" id="ENOG50322Z5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148666_1_0_0"/>
    <dbReference type="OrthoDB" id="1960657at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="12691" checksum="FEC4611425B76EC0" modified="2012-07-11" version="1" precursor="true">MLRYIVKILVSSVIIALVSEVSKKSGYIGGLIASLPLTSMLALFWLYNDTKNSSKVAELSTGILVFVLPSLIFFVAMPLFLRRGINFYVALALSSGVMMAGYAFFSLILSKFGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N4</accession>
    <name>I2F6N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731389.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1942"/>
    <dbReference type="EnsemblBacteria" id="AFK07587">
        <property type="protein sequence ID" value="AFK07587"/>
        <property type="gene ID" value="Theba_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1942"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_0"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="390" mass="41883" checksum="3FF06B59AAC27EB3" modified="2012-07-11" version="1">MDRISNFEYFLPTRLVFGVGSLNRVGEFAKSLGKKALIVTGKSSTKKTGLLDKVIAILEKNGVETAVFDEIVPNPLSSTVDKGAEFANNERCDLIIGLGGGSPVDSAKLIAVVAKDGGKCWDYTGSGGGRIPKSALPVIAIPTTHGTGTESDPFAVVTNTETDEKIGVGFDQTFPTVSIVDPEVMKTLPPYQTAATGMDAFYHAIESYINTNHQPTSDLLALEAMSLINHYLPIAYRDGNNIEARTALAWASTAAGICETLSGCIANHSIEHPISAHYNATHGAGLCATGPAFFDYIRPHTKERLARVAQIMGAPESEVDIDKLSKMSIELIHRLQKSVDIDITLKDLGVEKSMLGRLAEDAMRTMGALVEVTPGNLKTKDLERILEMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P2</accession>
    <name>I2F6P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488160.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1950"/>
    <dbReference type="EnsemblBacteria" id="AFK07595">
        <property type="protein sequence ID" value="AFK07595"/>
        <property type="gene ID" value="Theba_1950"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1950"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_1_0_0"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="621" mass="70541" checksum="0E801C4A6C427902" modified="2012-07-11" version="1" precursor="true">MTFVNDTSRSPRAQVRPLAIEKVELQGFVGRYQGLMKSTSLPMQYEYLESTGRIDNFRKAAGNMEGSFTGWFFNDSDVYKWIEAASYSLSYNEDPEIRARIESLITLIEKAQEISGDGYINTYFVGQKAGERWKDLKNMHELYCAGHLIQAGIANKRASGDETLFKVCVSAADNILDSFRDDDCKVTTGHPELEMAMIELHRETGNRDYLKFAQMLIDNRGRGYVGGDEYHIDHVPFRELKELTGHAVRMLYLLAGAADIFLETGDETLLAVLERLWIDLTARKMYVTGGAGSRYEGESFGEEFELPSRRAYAETCAAVGNVFWNWRMYMISGDAKYLDLFEQSFYNGVLSGISLDGKRYFYVNPLEDAGKREREEWFECACCPPNIARLLTSFGGYIYGTTLNEIRVNFYEESKATIPFRDGEVSIIQKTSYPHSEEVQLTVATDLDTELSILLRIPEWTEGEFEVQVDGIKQKLRPEKGFVRLEGNWKGKTEVYLALPMRIRLMTANPLLRENTDKVSVQRGPLVYCAEGVDNPDFDVRTLSVPSRKNFEVTQSDALPGNPVILSGKGVAFDLDGWEKKLYNPLGSVKSKGNNVRFSLVPYYAWNNRGKSTMCVWLHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R4</accession>
    <name>I2F6R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731409.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1974"/>
    <dbReference type="EnsemblBacteria" id="AFK07617">
        <property type="protein sequence ID" value="AFK07617"/>
        <property type="gene ID" value="Theba_1974"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1974"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635857_0_0_0"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="431" mass="46303" checksum="DE773623613FE12F" modified="2012-07-11" version="1" precursor="true">MLRLIGGNMKRVLLITMILIGTFALSQIHLEDSVTFGSEGDDVANDLVVLSDGKLLLVGYTTSFSGELGSSKGEEDFLILKLDERLRIIWSKTYGGSGRDIAEAVLETSDGEIVVVGLTESSDGDVSESDKLGDFWVVKLSPTGELLWEKTFGGSSQDHAYDVVESPSGNILVAGYTRSPDGDIEGHVWGEDFWIVEISPSGQVLKQWVLDGGNNNEDLARKLFVNDMGDILITGYTAYKDVGISCNYVNEQAALAIIHAEGISSYYAFGGMYLEDGYDVLASEETIVIVGEQDAGISMFSTGLGGKDFYVVAIGEKGQELWSENYGGTFTDIARVVKPFGASDLLVAGHTTSQDIDIEDPLGMTDGWIIVVNENGELVESLSVGGSADDFILSGVNYGEKYILCGCSTSSDGDLESNKGKKDIWLITLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S2</accession>
    <name>I2F6S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">Theba_1982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731417.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1982"/>
    <dbReference type="EnsemblBacteria" id="AFK07625">
        <property type="protein sequence ID" value="AFK07625"/>
        <property type="gene ID" value="Theba_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1982"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_1_0"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="167" mass="19711" checksum="D7523A55253577C1" modified="2012-07-11" version="1">MQEEIVLDIMIEIPKGSRNKYEYDKKFQRIRFDRTLFSAVHYPMDYGFILNTLAEDEDPLDAMVLLWEPTFPGCLIEAKPIGAFKMWDEKGPDEKVLCVPIHDPVWNYIETLDDVPPHLLKEIEHFFSVYKDLEKKKTGIEGWVRREETLEIIAASRVRYLEETQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z9</accession>
    <name>I2F6Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Desulfoferrodoxin FeS4 iron-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 2 irons ions per subunit via 4 cysteine residues per iron.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487931.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2064"/>
    <dbReference type="EnsemblBacteria" id="AFK07702">
        <property type="protein sequence ID" value="AFK07702"/>
        <property type="gene ID" value="Theba_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2064"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212433_0_0_0"/>
    <dbReference type="OrthoDB" id="1496450at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00974">
        <property type="entry name" value="DSRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004462">
        <property type="entry name" value="Desulfoferrodoxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038094">
        <property type="entry name" value="Desulfoferrodoxin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012002">
        <property type="entry name" value="Desulforedoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06397">
        <property type="entry name" value="Desulfoferrod_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000075">
        <property type="entry name" value="Desulforedoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00319">
        <property type="entry name" value="desulf_FeS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrod_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000075-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="41" mass="4441" checksum="EE218913964C024A" modified="2012-07-11" version="1">MKVKNVGEVYRCEICGNIVEVKEAGGGELVCCGEPMKLVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F706</accession>
    <name>I2F706_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731486.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2072"/>
    <dbReference type="EnsemblBacteria" id="AFK07709">
        <property type="protein sequence ID" value="AFK07709"/>
        <property type="gene ID" value="Theba_2072"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2072"/>
    <dbReference type="HOGENOM" id="CLU_2396248_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10788" checksum="2913E5169CB06BE1" modified="2012-07-11" version="1">MYLKSEVEMMSNDKTLIETLSQSLMGLSIIERNTRGMIFVDNQRSPNLIVVWNYCDTVLVGGESEKISEKKLSRFLFETLLRPLAREREAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F726</accession>
    <name>I2F726_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731506.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2095"/>
    <dbReference type="EnsemblBacteria" id="AFK07729">
        <property type="protein sequence ID" value="AFK07729"/>
        <property type="gene ID" value="Theba_2095"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2095"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_45_1_0"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="211" mass="24490" checksum="1AD341189E429053" modified="2012-07-11" version="1">MPKETFYNLPKTKRKRILEAAIDEFAENGYENSRVNEIVRRSSIPKGSFYQYFENKSDLFRYVLDIIYKKKMEIMTGIEISHRELSVFETLRVMVEAGIKMAEEDPRLLKISDSLVANKPLMDEVLIEYAPSSDDFIISLIRRGKNNGELADWVDPELSAKLITAFMLSLSEMIRSSSNGKITDETRKKYLSLINLLEYGMKRREDYDSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F747</accession>
    <name>I2F747_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487843.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2116"/>
    <dbReference type="EnsemblBacteria" id="AFK07750">
        <property type="protein sequence ID" value="AFK07750"/>
        <property type="gene ID" value="Theba_2116"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2116"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031786_2_0_0"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="461" mass="50283" checksum="B861DB028B6295F9" modified="2012-07-11" version="1">MDRKLDEMVIALKDELVSAVSDSVRVKSVQDTPVDGGPFGKGVKESLEKTVKLAKDLGFEARNADGYVGIVDYGSGETFGVLGHLDVVPEGEGWEVPPYSGLVKDGEIWGRGTQDDKGPMIAALYALKAVKEYVKKPSKRIRLIFGTNEESGWECMKYYVKHEEIPDMSVTPDADFPVIFAEKGIVNYGISAPAHNGGEGISVEVLSAGEAPNMVASSARAVLRGVDAESYEKIEAFSPKNDTKLKLTRSEDKVEILITGSSAHGSTPYKGQSAIAAIVDLLADLRLGDSEIKNFLTAIKSKIGYEFYGESLGISGKDSMSGELTLNAGTLRLQAGVLKLVINIRYPVFFNESMIRSQIEEAFKGFRVETFHHQKPLYISPDSELVKMCREVYKEVTGHDEEPIAIGGGTYARAVPNAVAFGALFPGNVEMAHQPNERVSIEDLLLVSRIYAQLFLRFLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F776</accession>
    <name>I2F776_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731547.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2145"/>
    <dbReference type="EnsemblBacteria" id="AFK07779">
        <property type="protein sequence ID" value="AFK07779"/>
        <property type="gene ID" value="Theba_2145"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2145"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_0"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="13435" checksum="D1CA9A9BF4FB0589" modified="2012-07-11" version="1">MSELCPSREIHVDVDKYRLIAKEVSGLSDLFKVIADETRTKIVFLLSETELCTCDLAEILRLSLPTISHHLKQLKSYRLVKSRREGKSVFYSLEDFHVVELIKLAREHFQELSEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F791</accession>
    <name>I2F791_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731562.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2161"/>
    <dbReference type="EnsemblBacteria" id="AFK07794">
        <property type="protein sequence ID" value="AFK07794"/>
        <property type="gene ID" value="Theba_2161"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2161"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110408_0_0_0"/>
    <dbReference type="OrthoDB" id="2044023at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="28268" checksum="BA09E0600DF219E6" modified="2012-07-11" version="1">MDTLKLEEKWLQETLPGGIVYPSSTVISGPGGSGKPLVEYAFVASWLKAGGSVISIPLQYPTMEMGKTALKDLYRVDLNDYENHVSYIQFEPDMDKHEEIGKNTIKANLLKPEVWKSVVETANNMLEPSELGTLVFGSALNLLLFSPTYRQGMLNYITEVIKSDKSKSYMFSVSTSAFADEIKQWEEAEDNLMFTRMEDDMSLFFSVCRMKEVPFSTEEVKVPISEKQLDKIKEIAHATRSKIIPKLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F797</accession>
    <name>I2F797_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2167"/>
    <dbReference type="EnsemblBacteria" id="AFK07800">
        <property type="protein sequence ID" value="AFK07800"/>
        <property type="gene ID" value="Theba_2167"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2167"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495011_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="349"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="557" mass="64249" checksum="C2F3DB93B059E27D" modified="2012-07-11" version="1">MKNSRICGLALRFNYDNPEDFRSELRSIYEQEDLSREEIGMLLALDFAYSSTFDEAREFDSSGTDLKLLAEGVYSLSYFYARNSEDKIAYLVSKLAVDHIARECEREQEINLKILHMMTSFEMGFGEETLLLFEELMKLEKYVPVQKRFEYYNDLGLVSTQLRTGGNPLRFYEKAKELAGSPVRALMVQLNMIDYLYSKNMFKEALKLLDKTESCNVVSINGYRLMINLKILLQMSSLARATAVADQLESLIRSHGEWTDIAVSYIFLGHFYVKIGNISKAQNYLNLLKSLPDESLTNYIRGETLILEASIMQAKGEHFRALENSVGAFETLTLYSTTSPHLKDFVNNLFGSISAVFTQLIRELRLKDSYTALHTLRVLKICYEFGKELELEKIDLFNLSIGAMLHDYGKVDIPFDLLNKPSKLTEEEFTEIMNHPVYGERYLRDLNFPIAIRDIVRHHHERIDGKGYPDGLKGDEIHKLVQIVAVADVFDALTTDRPYRKAITKEKALEYLEEKGDQLISKGLLSRFIRFAQHKEISIQEKEITVLWRSIISELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A8</accession>
    <name>I2F7A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE-like protein with response regulator receiver domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2178"/>
    <dbReference type="EnsemblBacteria" id="AFK07811">
        <property type="protein sequence ID" value="AFK07811"/>
        <property type="gene ID" value="Theba_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2178"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_7_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="368" mass="41319" checksum="3BB29E675B7B0E4A" modified="2012-07-11" version="1">MVDDDLSVRVLLKSILSRDNHDVVESADGRSAFSSLAVQKPDIVLLDLMLPDYNGLDILAQLKESEELEPIPVIVLTGSSDRESKLTALSSGAVDFISKPFLPEEVLLRVNTHLKLHDLIRSLRVAVDNLESDVIAAGKIQNALVPKSNPQGLSVEWIYEPSYRVGGDIFDIFKLDENRYFVYLADMSGHGVNAAMLSVMVHRFIEDFRASIYDGEFDLRSFMKELDRNFIFERFNLFFTIVSAIVDFKEGFVLLSNAGHPTPLMQREGSVQFLEGKREALVGINMIHGDVSKVPFRSGDRLLLYTDGLIEVMNEKGEMYGEERLRNLMKSSSDIDIRSTALHLKSSYESFKGSTLAEDDITALLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C0</accession>
    <name>I2F7C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731587.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2190"/>
    <dbReference type="EnsemblBacteria" id="AFK07823">
        <property type="protein sequence ID" value="AFK07823"/>
        <property type="gene ID" value="Theba_2190"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2190"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663581_0_0_0"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658412" evidence="1">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="46583" checksum="5537AA930E305885" modified="2012-07-11" version="1" precursor="true">MKRTMLFLILSLCFVTTFAAGLTGYLTQQIPWMAGNEMTLVPLSESKPDTLEAPSIKGLKYGLLELGAKPIVFALIPGEIPLLWIDANNNSNVLDDPTIAPDFKETHQDTTTYEWITRVKTFYELEGYWESRSVKLLARKTGLTGELEFRYCLYEHMEGLVWAEDGPRKLKLFTLDPKGFYSTDQVYFGVDTDGDGEIALIHDSYEIFLHGEVFSLNGKAYRLGEVSKDGKKVSFEETGYAPTEKPRFLKGDALPIPGVLQTDPIVNAAFFEGSPSLIVLSKVTPATVVEPVYSDCDCISLSAFERFRLDGIIDLAQRYTDLKVLWVLTGKEQVEPEAALLENIYLRDEKALVDFYGFPGEERVFIVDSKGVIAELDSYWVDEASLDTDRPQNGKLMLNYSDIRKTVEALYKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D4</accession>
    <name>I2F7D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="ORF">Theba_2204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731598.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2204"/>
    <dbReference type="EnsemblBacteria" id="AFK07837">
        <property type="protein sequence ID" value="AFK07837"/>
        <property type="gene ID" value="Theba_2204"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2204"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_2_0"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:intracellular protein transmembrane transport"/>
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        <property type="term" value="P:protein targeting"/>
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        <property type="term" value="P:protein transport by the Sec complex"/>
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    </dbReference>
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        <property type="entry name" value="SecD"/>
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        <property type="entry name" value="SecD/SecF_arch_bac"/>
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        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
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        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
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            <end position="38"/>
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            <end position="362"/>
        </location>
    </feature>
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            <end position="392"/>
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    </feature>
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            <end position="462"/>
        </location>
    </feature>
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            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK07837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="515" mass="55308" checksum="F879CFF85FF6E888" modified="2012-07-11" version="1" precursor="true">MEGGVCPSLSGKVRMRANQKRLIVTVVVFVAALLPLLIPHGSAPAGSSFIDKLAANIKLGLDIKGGALLEYQMLTDVSDQEMNALADRVIEVLRARLDAAGFTEATVEKVTTGISFGEDIPPVRVRVQIPGITDVSRAESLVGKTGRLYFADVLAIETSVSTPSIPAGMSLEISRRKLQGAEPYWVKELHYGEYVGGVQNNTWYFISPKVSIGSSYAELDGSVVTDAKPLVNNQPRPGQGRFMVSLKFSSEGAKTFRDITSVKSTYADTDMKKRLAIVLDDRVIIAPLVQSQISDGNAVIEGLNSIEEAKEVSILVGSGNLPVDLASFNKRVLSPTLGRDIINSSLWAGVAGIVIIMIYMVVFYKKMGIVADIALLYNAVLLFGMISLTGSILTLPGIAGIVLTIGMTVDGNVLIFERIKEELRLGKTPENSIDSAFSKVVWTIFDANLTTILAGLVLFYFGTGTVKGFAVTLIIGVVGAMFTNIVVSRTVLTGMAGSLKPHRYVEVETEGRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E9</accession>
    <name>I2F7E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2222"/>
    <dbReference type="EnsemblBacteria" id="AFK07852">
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        <property type="gene ID" value="Theba_2222"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2129957at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
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        </location>
    </feature>
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        <location>
            <begin position="312"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="383"/>
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        </location>
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        <location>
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    </feature>
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        <location>
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            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="528" mass="58491" checksum="2FFDDE232E4C9410" modified="2012-07-11" version="1" precursor="true">MRMLTRQGKRAFVASFLAVAFVIMIAVPIAFYLRGYLVPNFSRVADLSDQLRELTGIDLKLIVVSFFSAIIFSILLGSDLPIVVSNLFFSERVKMLLNLPVRTATIANVQLLEVLAAGGLPILLFAPVFMAALRGLGYSDGRFWMALVLLFVFVLNTLAITAIISFVIVFLSKGRFLKTLSAMMTMVTLFVFIFTLRFMDFSAIDLAKPDQVAEQFGGLQSIVTSPYLPWSPFVRAITGGTRDLAVFIVSSIGIFSSLALLEIFLYSKVLQKLMTRPIGNVSPKSNGDFKVHGLFLGLLIKDSLLLLREPKLMFAVLYPSLFVPVVVLVNPGLLSSFGILQLLGLIVFLFSNYTTVSSTALFAFERQLGDTSWLFPIRRVKTILSKSFVITSLYSFVILLVGLYVSNNTSQYGTFMMNFILFMIPTIFVLSLLGGFLEKSFGTKDSKNVFKALSLSGAILSFLLSTLLPVFSTLPMTLYISGNIGLFLNFMNIPIVSPFTWLLGLVLPVSLWVSIAWASFRSLCYNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K0</accession>
    <name>I2F7K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07903">
        <property type="protein sequence ID" value="AFK07903"/>
        <property type="gene ID" value="Theba_2274"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2274"/>
    <dbReference type="HOGENOM" id="CLU_2683579_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="74" mass="8229" checksum="64C14A958B3E19C3" modified="2012-07-11" version="1">MSFRKNNVGNDKPLERGFRSRARKSRVWGLERAEVMLGRTSQEVMPGVASGEVRLAARGSDAASQEATKRKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K6</accession>
    <name>I2F7K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487582.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2281"/>
    <dbReference type="EnsemblBacteria" id="AFK07909">
        <property type="protein sequence ID" value="AFK07909"/>
        <property type="gene ID" value="Theba_2281"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2281"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="322" mass="36020" checksum="A680C66286A5671D" modified="2012-07-11" version="1">MSGDILVLEGVRKHFPVNSLRRHGKFVHAMDDISFSLRSGEVLAIVGESGSGKTTTANVISRIYRQTEGSVVFEGRELSGKMTRTEELKYHKRVQMIFQDPFGALNPTRTIGRIMERPFVIHRIAEDRKAVSEKVDSTLTQVGLEPPDQFKRKFPHELSGGQRQRVNIARAFAVEPDLILADEPTSMLDVSNRMSIMNMMLSLKESHGVSFIYITHDLAGARYMSDRIIVMYAGMIMEIGPAEEIITNSFHPYTKLLKSAAPAPETGLKRKPLITGGDIPSLIDPPNGCRFHPRCPFAKEVCSLEIPPMKKIGDDHYARCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M2</accession>
    <name>I2F7M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAMP superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731680.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2297"/>
    <dbReference type="EnsemblBacteria" id="AFK07925">
        <property type="protein sequence ID" value="AFK07925"/>
        <property type="gene ID" value="Theba_2297"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2297"/>
    <dbReference type="eggNOG" id="COG1337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081549_0_0_0"/>
    <dbReference type="OrthoDB" id="1072279at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="274" mass="31173" checksum="9C236FA58C393837" modified="2012-07-11" version="1">MSWELHRVSLKLLSPMHIGWRKIGNLQQTRYYVPGRTLWGALTARLARDYGDFDYSKTGIDVDKSLRFSYFYPSDNEEKIDLLPWERKDEFEWKYIGSTVNTALDLGARIADEGSLHETEYIAPKTRDGKQVYLIGNIFEHKDCALNWEDALSKLQIGGERTYGWGRVETDESKGCVQVAQIDLDGYDIELNEEFPVIKLSRSHSAISHVLADNQIDSSALSGNIEPLIGLETTREERFGAEISAAQICWTPGTKFSKDHTFLIGEKGIWKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N3</accession>
    <name>I2F7N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731691.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2309"/>
    <dbReference type="EnsemblBacteria" id="AFK07936">
        <property type="protein sequence ID" value="AFK07936"/>
        <property type="gene ID" value="Theba_2309"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2309"/>
    <dbReference type="eggNOG" id="COG3649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071770_0_0_0"/>
    <dbReference type="OrthoDB" id="598606at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013419">
        <property type="entry name" value="CRISPR-assoc_prot_Csh2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02590">
        <property type="entry name" value="cas_Csh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="36095" checksum="2F2802DC694071B4" modified="2012-07-11" version="1">MSIKNRHEIVFIYDVKDGNPNGDPMDSNKPRMDVATGVNIVSDVRLKRTIRDHLAEMGEELFVSGDPITSEKRASLLITDLTDETYNKKAVEEALKLHKREGASKLLLEKCIDLRLFGGTVPLTGLNMSITGPVQFRFGRSLHVVDPVFTQGTAAFVSQEGKEQRSFREEWTLNYSCIAFYGVVNQNTAKHTLMSDEDLSKMLNAIWDGTKDLITRSKMEQLPRLLIDVVYLEEANFHIGELDKGIKLQSNMMEEKIRGISDFRLEISDLKKLLTQYKNKIQEIRYRIDPRLNIVENGTLFDLDTLLEGKMKRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N5</accession>
    <name>I2F7N5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR-associated endoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731693.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2311"/>
    <dbReference type="EnsemblBacteria" id="AFK07938">
        <property type="protein sequence ID" value="AFK07938"/>
        <property type="gene ID" value="Theba_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2311"/>
    <dbReference type="eggNOG" id="COG1583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089858_2_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005054">
        <property type="entry name" value="PF1131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="244" mass="27492" checksum="28B27E2F9402C541" modified="2012-07-11" version="1">MRIKVSLKSEKPISLPISYSHPLQSAIYKILSDVIPESHDFGLTVNKRTLRPFTFSRLFGHKQSINEGSISLTSPICLHFSSPLEDYVQAFANGLMKNGGIKLLGATLDLRSIEVEPTLPETKYIAAKTISPITVYSTLMTADGRKKTYFYNPAEKDFTIQIQENLNRKASALGNSVRARESFSFKLASRPVQRIVKYKDFTQIAWDFRFELNADPELISIAYSWGLGSKNAQGFGMIEISERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P7</accession>
    <name>I2F7P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731703.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2324"/>
    <dbReference type="EnsemblBacteria" id="AFK07950">
        <property type="protein sequence ID" value="AFK07950"/>
        <property type="gene ID" value="Theba_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2324"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064798_0_0_0"/>
    <dbReference type="OrthoDB" id="1753337at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="30556" checksum="ED0E7FF54A4AF9C2" modified="2012-07-11" version="1">MEDRIAKTLALLLDGRWNEAFKLYHEIINDLSKEKSVPETVENTKDSQTSSKTEEAVSVVSEFERWPTLNDEELWDLGHIAYLFDDTETAESLIEEHYSRKPNDIEGMVFLGMIYKKRNKPYKSELMYRAALSEDKDNMKAVEELVYLYLETERPLDALAWVQKLLRLDPRTPKNYFLAGKALEKLDREEQSRRYIIASMILDQSSSFRGSLQSFYEDRLGESITIADLFDGKEVIEEWVGKNRHAVDRSPFSEFEHQESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U6</accession>
    <name>I2F7U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489991.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2379"/>
    <dbReference type="EnsemblBacteria" id="AFK07999">
        <property type="protein sequence ID" value="AFK07999"/>
        <property type="gene ID" value="Theba_2379"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2379"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143271_0_0_0"/>
    <dbReference type="OrthoDB" id="1935374at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="141" mass="15558" checksum="81B449E819D9FC24" modified="2012-07-11" version="1">MKIGIIAYSKTGNTLYVAEKLRDRLISAGKEASVIRLRSETPDLERYEGLIFCSPVNGGAPADPMKSYLAKMKSLQGKKVALMATGLFPASMGRKQTLKYMKSICKDKGAEIVGQGSVGWWSFGREKKIEKLVEDLSSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F849</accession>
    <name>I2F849_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic component of amino acid ABC-type transporter/signal transduction system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731834.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2492"/>
    <dbReference type="EnsemblBacteria" id="AFK08102">
        <property type="protein sequence ID" value="AFK08102"/>
        <property type="gene ID" value="Theba_2492"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2492"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029326_0_0_0"/>
    <dbReference type="OrthoDB" id="1632224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="SSF141066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658736" evidence="2">
        <location>
            <begin position="26"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="253"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="591" mass="66049" checksum="63E19541332B9439" modified="2012-07-11" version="1" precursor="true">MKSSIPKKVVFSIILVLFLSSIALAQPITFLVNPDYDPFSYLEEGHLKGFLVDLIGSLESETGIDVEMKPVKFDEALEMLQGEGSYCIPSLVFTTQRKALYQWAGPVAITNTYLYTTEELSGEFKSLEDARNANSVGVVSEYYSHKLLEGQGFDNLIVFEDEGSLLEALLEGEIELAPFNSAVLQELLKREQASYSPVSTVVIDLDMTYLGFSKEVPTEIVDAFQKALDGLKTSGSFSELYSEWFPGQPVPGIYTFLTEEYPPVTFRGEDGEPTGFVTEMVKEILRRNDMSAEILIVPWSLGYELASNLPNVFLFSMDQTEQRKENFEWIGPVGKNTAYLYGRKDTPATDLESAKRVDAIGTTTNWWTEQLLKEMGFENLVSSLDPLDTVAQLVEGETDLAVFTDLTVAELADEAGYSIDDLEALVELQTNYFYIAASKGTNLGLILNFQKTLNEMKRDGSFEETIREFVPNMLVTSLLWNSSQLDVKGLRTSMNTLSVGEIATMELQENGSTGYVWDVKITNPNVVSLIYEGSIFEGKFLDDSELVGAPYNVKWVFEAKQPGETVVIFSLRRPWESVHPIQTFAINIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F857</accession>
    <name>I2F857_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation initiation inhibitor, yjgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731842.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2502"/>
    <dbReference type="EnsemblBacteria" id="AFK08110">
        <property type="protein sequence ID" value="AFK08110"/>
        <property type="gene ID" value="Theba_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2502"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104845_0_1_0"/>
    <dbReference type="OrthoDB" id="1956412at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="17013" checksum="BDDCA16B2949159B" modified="2012-07-11" version="1">MLIEKRIKELGIELPPSSPPGAMYIPVKRLGNALFVSGQVPMKDGKPAYTGKVGKERSIEYAEEGARLFIVNMLAAVKAYLGDLDKVVNIVKLQAFVNSETGFDRQHIVANAASELLYQIFGEAGRHARTAIGTNQLPLDFTVEIEAVIEIREND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F885</accession>
    <name>I2F885_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2534"/>
    <dbReference type="EnsemblBacteria" id="AFK08138">
        <property type="protein sequence ID" value="AFK08138"/>
        <property type="gene ID" value="Theba_2534"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2534"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="33391" checksum="9C0F97380AB87704" modified="2012-07-11" version="1" precursor="true">MMDNRNRKRKFPLSKLWTPLLLVVLFLIFGLQYPTFLSAKNFNNLLVQMAILLIASMGMSMVVLMGSIDVSVGATITITAVASAMASSALGGASIIVGMIVGALVGLINGFLATFLKIPTFLSTIAMMGILNGTAVLMLKGSPYNVSSESFLAVARGSFLDGISNLITIPIIVVLITLLITKKTVLGRMIYAIGNNEYVCQYSGISVVKIQTFVFMIHGSLVGLAGALDASMLEAACPYTGDTYTLPVIAIVVMGGIPLSGGRGGPIGTVLGAMLVTVLISGLNFMGVTPEFRNVAMGALIIAGALMSNVGRPKMITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F888</accession>
    <name>I2F888_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase, phosphoprotein-dependent, L subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731866.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2537"/>
    <dbReference type="EnsemblBacteria" id="AFK08141">
        <property type="protein sequence ID" value="AFK08141"/>
        <property type="gene ID" value="Theba_2537"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2537"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066424_5_0_0"/>
    <dbReference type="OrthoDB" id="1689902at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="22917" checksum="32C966CABA404917" modified="2012-07-11" version="1">MTVISKDEFIEIVGIAVDSILENEQYFCDLDSVAGDGDFGASLAKGFSEVKSKWKDLEKSNVGTFLRDCSMIIMEKCGGASGPIWGNAFLSASRASKGKETLEIADIAELFQAMVDGVQKVGKAQLGDKTLLDALIPFKESLKESAKLNEPIEAAFDKAATKAEEGAESTKTIVATKGRARYLGVRSIGAYDAGARAVAVILSDIQKNFFNKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B4</accession>
    <name>I2F8B4_9BACT</name>
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        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, permease component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731887.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2567"/>
    <dbReference type="EnsemblBacteria" id="AFK08167">
        <property type="protein sequence ID" value="AFK08167"/>
        <property type="gene ID" value="Theba_2567"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2567"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_0"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="29216" checksum="4E99FBE25493709A" modified="2012-07-11" version="1" precursor="true">METKKVIGKRRFSMTIATLAFVFLYLPIIALVLLSFNSSRQGVSWTGFTLKWYSELFRQADVWRAFLNTVIIAFSSSLVATAIGTFSAMALYWYQSRLKGYLGILVYTPLIIPDILMGVSMLIFFVAIGIPLGLFTIFIAHVTFCVSYVTVTVMTRLEDFDYSVVEAARDLGAKTNQVFRKVILPMIMPGIMAGFLLSLTLSIDDFVITFFVAGPGSTTLPLKIFSMIKFGVSPVINALSTLLLVGTLFISFFGSRFRKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C2</accession>
    <name>I2F8C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731893.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2575"/>
    <dbReference type="EnsemblBacteria" id="AFK08175">
        <property type="protein sequence ID" value="AFK08175"/>
        <property type="gene ID" value="Theba_2575"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2575"/>
    <dbReference type="eggNOG" id="COG3889">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_1_0_0"/>
    <dbReference type="OrthoDB" id="63045at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="91"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="832" mass="92663" checksum="13CC82B91BD7E189" modified="2012-07-11" version="1" precursor="true">MKKLTYVLLVMLLLLGGLALSSQKGPYPDLVYFNVRMSEEIALKDTAEGLTDIFMWGLSGPQIFGLDQATRDKLDLYAVPSGSWSLLMNPIPNKAPYVVEVGGKEYFNAFAIRDIRFAMNDLINRQYLVDEILGGAGTPAFTMATTGQPGTYRYNLLATKFGLTAEGNEARALQVIESSMQAAAALPENAGRLVKQGDGFWYFDNEPVTIKIAIRVDDPQGRLKEGDYIGDQLEKAGLKAERLYWDRIKCSNVVYGGDPAEFTWQMYTEGWGAGATRAFWEHIVAQMYAPWYGYMPGGMTEGFWNYEQDEIDEVTLKAYTGNFLTEEEYWELALRGLELGLEEAVRIYVVNQLDFFVANASRLKQRFAYGLGDGLNTWSIRTAVTDDRTLFITQFSAMGSLFMDAWDPIGTDGFDSVYSNYIAENLYDSAMFESPASAIPTPLRAVPVEVQTKARRNEEGDVVGDYEVPANAINYCPFNEAWLQVGEGNKSISMATYEFKFGKLHHGQPITIVDFLYAQAFQMEWANKEGDDDLQYEQAYSSSLKSGLDTIIGWVLNEDDTITVYFNYNFPASKERVASWAAPGISVSSSGHPVGCAWEIAEAMSLLVTEGSESGTAYSITMDPAFTEVDAIAPACVKDIRAKLVEMKERKHIPNYIKEFVDEEYVLGRYEAAIEFIDNYGHAYISNGPFYLSKFDSTSNFIELRAFRDPDYPYEDTYWIEELKAIRMEINSLETPSFVAKGSDIPVNVYVSEVTYPIDEAVPATTGKVTLSLIVGQETREFEAAMTEAGLFECVIPASAVMDLDPGSYDIMAIAELEGAIPASASTSIVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I9</accession>
    <name>I2F8I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731948.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2642"/>
    <dbReference type="EnsemblBacteria" id="AFK08242">
        <property type="protein sequence ID" value="AFK08242"/>
        <property type="gene ID" value="Theba_2642"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2642"/>
    <dbReference type="eggNOG" id="ENOG5032T6B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969118_0_0_0"/>
    <dbReference type="OrthoDB" id="1665502at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025491">
        <property type="entry name" value="DUF4382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14321">
        <property type="entry name" value="DUF4382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4382" evidence="1">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="287" mass="31779" checksum="61A63592C49BC743" modified="2012-07-11" version="1" precursor="true">MKKLSLSIILLITLFFAGCMEFPSQEPDIGTVRVFLTDAVIPVEDIDSLMVRIESISLYGDEDQPVVISDTPFEVDIVTLVGATYELPNTSSVSGIYNQLRMEVGAATLTANGEIFPVTVNSGSLKINDLDLTIDENATTTVVLDFDLSKSLIINGRWEDLKIEEDNGGINSRKDKVHMTPVLHVRHGSLFDVTGVASSSIYPLLVALFPENGGEALTTFTHEDNSIWDQGEFRFCKVVSGDYRIEFFDNYTDEGFSIDESESRYQPLFVTVVDRDVDLGTIVLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N9</accession>
    <name>I2F8N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731987.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2693"/>
    <dbReference type="EnsemblBacteria" id="AFK08292">
        <property type="protein sequence ID" value="AFK08292"/>
        <property type="gene ID" value="Theba_2693"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2693"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_2_0"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="243" mass="28176" checksum="3BF1ABFACD0DA13D" modified="2012-07-11" version="1">MVEEILARRALTKSNIPLTDFTINPYVGCSVGCIYCFAKFIGSFKDYGGVWGRDVRVRKNLTSLLKREIIRHPKRPVFLSTTCDPYQQLEKRYEITRAILRILVSHRVPVYLMTKSALIRRDLDLLQTAEGEAKVLVTITTDREDVRKVLEPGSSSFEERLETIDLLRDNGIQTGAFVGPVLPMNATRVALELSKRVEEVHLDPLNYSFQVKNIFLKFGWQSWLEKYTFQEVEKEFRKHLHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q9</accession>
    <name>I2F8Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732005.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2714"/>
    <dbReference type="EnsemblBacteria" id="AFK08312">
        <property type="protein sequence ID" value="AFK08312"/>
        <property type="gene ID" value="Theba_2714"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2714"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_0"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="385" mass="43115" checksum="40DE2596E15AA3FF" modified="2012-07-11" version="1" precursor="true">MGFLQSQSISISVFLGIMLVITLSNLFVIKRMSRLKKAIPGPMVSILIPARNEEKNIFACVTSLLNQDYSNIEVIVLEDCSSDRTMEILQSLAKNSDNLRIIKGKALPKGWLGKHWACNQLSMEAKGEILFFTDADTVHSPSTVSFAVKAMQIEDLDLLSAVVKERTDTLGELLTVPFMVHSILSIFPLALAYRTKFQALSVTCGQFMMFRKKSYCSIGGHESVRDHGVDDLSLGKLIKKAGMKWRLYNASDLVECKMYESFKDACVGFLKNYFALFEYRLIPAIFVWTWILTINLFPLVMLILFISGAVTSPTIGISSTVSVLFSIIFWFLASAKFGLSPLVVVLYPLIATISSIIGYLSIIFHFFGCTKWKGRALVKKKSRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G8</accession>
    <name>I2F1G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487448.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0016"/>
    <dbReference type="EnsemblBacteria" id="AFK05771">
        <property type="protein sequence ID" value="AFK05771"/>
        <property type="gene ID" value="Theba_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0016"/>
    <dbReference type="eggNOG" id="ENOG502ZTGX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2396246_0_0_0"/>
    <dbReference type="OrthoDB" id="1957740at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10756" checksum="0C0F4903DC9932FD" modified="2012-07-11" version="1">MKRSVSLDLGGRKYTFLTSDPQELVDQVFSKIGELYDSLKNNEEEIGYEKILVGISVNLAHDLVRSQNELLRLKAKYEEVLSEYFQGRDEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H0</accession>
    <name>I2F1H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729954.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0018"/>
    <dbReference type="EnsemblBacteria" id="AFK05773">
        <property type="protein sequence ID" value="AFK05773"/>
        <property type="gene ID" value="Theba_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0018"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_0_1_0"/>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="320" mass="34057" checksum="81FE96EBDD3A7AF1" modified="2012-07-11" version="1">MSKIVLVGGGTGLSTFARVIKDFVTSLTLIVAVTDDGGSSGILREALGMPPPGDVRNNIIALADDEELLTKVFSHRFSAPAMNGHSLGNIIIAGLMEMCGGFSEAVLTASRMLKIKGIVLPVAEDLVSLVGELDDGTIVKGESRVSAAGKRLKKVSLDRTCEALPEVSDSLVSADTIIIGPGSLFTSVVPNFLVSGVKEALKRSQARKIYVCNIMTQPGETDDFSLAKHVQIAESYCGVEFDLIFWTEIGGVASSVLSRYEEKGSRPVENDMISDGRVKVITGATTEFIDDGRRRPVLRHSRAGIISILHELGLLGEEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P4</accession>
    <name>I2F1P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730017.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0098"/>
    <dbReference type="EnsemblBacteria" id="AFK05847">
        <property type="protein sequence ID" value="AFK05847"/>
        <property type="gene ID" value="Theba_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0098"/>
    <dbReference type="eggNOG" id="COG2421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_1_0_0"/>
    <dbReference type="OrthoDB" id="228571at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="291" mass="31403" checksum="8B5771AD7C0B068E" modified="2012-07-11" version="1">MLHRIGRDRVVYDMSPEHKPVLEVSPGDTVIVETEDCFCHRIVLESQTVGGDFDFTHVNPATGPIAVKGAMPGDTIVVSIESIELDSQGVVETCPFWGPVSNVSRECVTEIVKIDGNFMSFLGERIEIKPMIGVIGNSPAEGSVSCTTPGSHGGNLDTKDIAAGSRVYLPVFVKGGNLSLGDVHARMGDGEVGGTGVEIRALVRLSVDIDKMPVESPTVETEEAFYLLFSAKTLEEASRGAVKRAIEFISDWKSIPAERAYMLTSITCDLMISQVVNPLVTVRVRVPKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q0</accession>
    <name>I2F1Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490185.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0104"/>
    <dbReference type="EnsemblBacteria" id="AFK05853">
        <property type="protein sequence ID" value="AFK05853"/>
        <property type="gene ID" value="Theba_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0104"/>
    <dbReference type="HOGENOM" id="CLU_1625133_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="163" mass="18260" checksum="36F2A6229132232E" modified="2012-07-11" version="1" precursor="true">MRLVLIVFVVIASVGLSVDIQQIEPLIGSYSEFTSRGYEMEEGSFATVTAIPFDAISNLDFPIKDVVGLLFFELPEGPSRVSFLNVAVTGKCKRGEPVEGVWADLFIIGEEYIFQTERYNPYIAIDSEGLLIAFCVYLDTSIYYSVTLEGRIMDVQWEFNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U6</accession>
    <name>I2F1U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730064.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0157"/>
    <dbReference type="EnsemblBacteria" id="AFK05899">
        <property type="protein sequence ID" value="AFK05899"/>
        <property type="gene ID" value="Theba_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0157"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_16_1_0"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="103" mass="11807" checksum="DDBDB970A285CFB7" modified="2012-07-11" version="1">MKEITLRELREVTGLVLVDFFSPGCGVCTAIETKLVAVEKDFPSWKFFKINTVENPAVASEYSVFTVPTIVVQTDGREQKRWSRYFSLEDVIEFLHEIDETEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W1</accession>
    <name>I2F1W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730078.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0174"/>
    <dbReference type="EnsemblBacteria" id="AFK05914">
        <property type="protein sequence ID" value="AFK05914"/>
        <property type="gene ID" value="Theba_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0174"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1784338_0_0_0"/>
    <dbReference type="OrthoDB" id="2165929at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="16676" checksum="CB95A5ABADFC6E8D" modified="2012-07-11" version="1" precursor="true">MKNRKRGFSLVELLIVLAVIAALIATITPVALNAIRKSQATKVAQNIKTLASSFENLLYVEGKSGIPSDISGLGRDIDETKYNIAYSTTDNGGYEVYVWTSEEAHEDTLVNVLPSAKKAPVGGIASLVTGFEKPNLGGTNAASATYYYSYTFIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W6</accession>
    <name>I2F1W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730083.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05919">
        <property type="protein sequence ID" value="AFK05919"/>
        <property type="gene ID" value="Theba_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0179"/>
    <dbReference type="eggNOG" id="ENOG5033AWJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192037_0_0_0"/>
    <dbReference type="OrthoDB" id="2100064at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="83" mass="9479" checksum="BCF7A897CD7DF410" modified="2012-07-11" version="1">MKTQIVRVPFETHSRLKAMASASGETIGEILAKAVESYRRELLLEDTNEAFSKLKEQADLWKGELDEREEWEGSLLDGQSDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z0</accession>
    <name>I2F1Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="7" type="ORF">Theba_0208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730106.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0208"/>
    <dbReference type="EnsemblBacteria" id="AFK05943">
        <property type="protein sequence ID" value="AFK05943"/>
        <property type="gene ID" value="Theba_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0208"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_0_0"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="303" mass="32840" checksum="ADAF8DFC1EE3516E" modified="2012-07-11" version="1">MGVFSRLNDGLKRTREGFFKRVRKLLSFESLDSDSLEEIEELLILSDMGSETAEEVIEALKDRKDKGKEPIEVLKEVLVEILDIPFEVPQARPYVVSVVGVNGTGKTTTIGKLSKLYSSNGNKVVLAACDTFRAAAVEQLRIWSERANVDFISQGQGADSAAVAFDAVRHAVSKGKDVVIVDTAGRLHTRSNLMEELKKVHRVIGKASPGAPNEVLLVIDATTGQNGLVQAKKFKEAVDVTGIVLTKLDGTAKGGIIFAIVKELGIPVRYIGVGEKEDDLKPFDSREFVNALLSTGEEGSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F283</accession>
    <name>I2F283_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730179.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0305"/>
    <dbReference type="EnsemblBacteria" id="AFK06036">
        <property type="protein sequence ID" value="AFK06036"/>
        <property type="gene ID" value="Theba_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0305"/>
    <dbReference type="eggNOG" id="ENOG502ZXSH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2494282_0_0_0"/>
    <dbReference type="OrthoDB" id="1844146at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="86" mass="9419" checksum="51050929C98287E2" modified="2012-07-11" version="1">MVDTRKLDALIVVSQGDIIKVLSLLRNHGFQTKVFPTPPGLFPGCSLSIAVSSNVVDSVLVLLKQHNVEVMYSALCDENPVKSFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F298</accession>
    <name>I2F298_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730193.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0322"/>
    <dbReference type="EnsemblBacteria" id="AFK06051">
        <property type="protein sequence ID" value="AFK06051"/>
        <property type="gene ID" value="Theba_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0322"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="343"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="553" mass="61819" checksum="72A014D30C128959" modified="2012-07-11" version="1">MKKKDIVDNNTLQSTEISKEDLFEVKYMSRWQLVWRALRKHKLGLLSLWILIIMYLIALFAEFLAPNSPYEQTQGLSFAPPSKVHWTDEEGKLTAPYIYAWVMERDPETYRTTFAEGVSVGALTAIDKSTGEEITFRKGENGVKDIFLTIKTERYALDADGNRANIGQPDYSIIQNIKLNELELFERTQVSETTNKTTIDSLSPSRFRELQKIGPPVKVVTERTLHRVFAQKEDEIDDVVLEAISLYNEIIDLDGGDVELAQEFLAELEISPTLLGVIVEPEVKTYETVKYPVKFFVKSWEYKLFWLIPTNIHLFGTDQPSKLLLFGADRYGRDVYSRILAGSRISMSIGLLAIMITFSLGLSIGGAAGYFGGITDEILMRVTEVLMSIPSFYLLISLRAILPTSIPSHLTYLLIVVILSFIGWPGMARVIRGMVLGLKETEFVQAAVAMGYPSSRVILRHIIPNTATYIIVAATLSIPGYILGEAGLSFLGLGITEPSASWGLMLSQAQSIKAMTEAPWLLIPGIFIFIVVMGFNLLGDALRDALDPRSLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A2</accession>
    <name>I2F2A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0326"/>
    <dbReference type="EnsemblBacteria" id="AFK06055">
        <property type="protein sequence ID" value="AFK06055"/>
        <property type="gene ID" value="Theba_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0326"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="345" mass="38886" checksum="0C5BAC9DD0080D83" modified="2012-07-11" version="1" precursor="true">MQERPILSVKNLSTHFNMAEGVVKAVQDVSFDLHRDDVLGIVGETGSGKSVTVKSVAGMTDSPGFIAGGEILFFTDEFSKTGEKEYIDLVKLPKESFSKVRGKHIGMIFQDPMTSLDPMYTIGNQMIETIVHHKKVTEEEARERSIRLLEQVGIPKPSERINDYPFQLSGGQRQRVVIAIALSCDPEILVADEPSTALDVTVQAQILELMKDLQEQFNSSMIFITHDLAVIAEIATKISVMYGSYQMEMADSMEIFENPMNPYTFALLECIPRLDIKQDQLLPIPGQPPIMLNPPNLCPFLPRCSRATDRCYKELPRLEQLKDNHFVRCWNPITNRVLLVKEAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F2</accession>
    <name>I2F2F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491964.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0377"/>
    <dbReference type="EnsemblBacteria" id="AFK06105">
        <property type="protein sequence ID" value="AFK06105"/>
        <property type="gene ID" value="Theba_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0377"/>
    <dbReference type="eggNOG" id="COG5496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1914306_0_0_0"/>
    <dbReference type="OrthoDB" id="2208836at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="135" mass="15174" checksum="980A52AEAECC5CBD" modified="2012-07-11" version="1">MLDLERLRSLENSEFTQTVIPTDVSLRWSERYDVELLNLLSTSGLMKIVHSCGHNLISDFESDLLVSVVSETSVKHYSPILMEEELVINIRIVSVSDSAEVHFSGSVVQLGTEAGAFEFSRKFISVDFFRRAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N2</accession>
    <name>I2F2N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="495" mass="56309" checksum="125B1F9566E6E4E7" modified="2012-07-11" version="1" precursor="true">MKDWQRDSIVYQIFPDRFKIGYGKNVFQKREQGHYQLPKQDVRDWGEKPVASVDGSHQYDFWGGDLAGITEELDYIRDLGANTLYLNPIFWGHTNHKYDTVDYFKIDPDFGTEEEFLLLVETAHSKGLSIILDGVFNHVGASGKWANSLELFEEPGALQGNEEFRKYFFEGKKGLRGWMDSCNLLELNLENPILSNMVFRGTDSVVAHWLKKGIDGWRLDVAYDLGPRILKEIVATTKSVRSDAVVIGEIWNYPGGWPEQSHLDGLMNYYFRLVIWETLNGYLSGHDALKIIDEAIKEAGLTFISNSWTILSSHDVPRLKNELGSFQRVKAALVLQYCLPGIPLIYYGEEIEMDGGNDPENRAPMDWQSVSKETETRILFKKLNAIRETKASLRAGNFKPLISSDSSLISFKRTGEIVEDMVLCVVNPTANNIKSRVFLQEGFLMNGTEMKDLLTGRAFKVSFGTVSVDLGPFEALIMEPLIIRSDLHYSPYKRL</sequence>
</entry>
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                <person name="Bruce D."/>
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                <person name="Teshima H."/>
                <person name="Han J."/>
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                <person name="Noll K.M."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="181" mass="21409" checksum="B73CDAE3F39BF7DD" modified="2012-07-11" version="1">MLKGRKVYLREYRKEDIVLAHEYINDYEVKRMLVPGIPFPLRLEEEEKWYDSQSSSKDTYSFAIAKIEDNEYIGGCGINEVDWKNSVVTLGIFIAKKFWNEGYGTDAMRILLRFVFEQMNINRAKLNVYSFNRRAIRSYQKCGFRIEGTLRQEIFRDGSFHDEIIMGILKDEFGRNDQTSL</sequence>
</entry>
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    <accession>I2F2R7</accession>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
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                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
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                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
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        <location>
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            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="90" mass="10464" checksum="687B1F72AAABEE6B" modified="2012-07-11" version="1">MQNIEKIIDLVEELFDELENVDVQELTEALPDMEQDEVTELRSSIEDWVDGLDEIIARLPELQASILELKGDLERLNDSVVEMEEDFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S3</accession>
    <name>I2F2S3_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Bruce D."/>
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                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="31632" checksum="91CC29719554C2B4" modified="2012-07-11" version="1" precursor="true">MKTIRKQSVVVDVLIWAFLIVTAIVILAPIVFMFTASLMPSKDILKMPYSWIPKDLYIDNYWQAIRGNDGSFIYPRNILNSFIVAGAVSLSTVFLSALTGYGLAKFPFKGRNLVFLLIMATMMIPFEAIMIPLYLVATSLKIQDSYVGLILPFMVNAFGIFLMRQYLITFPDEIIDAARIDGSGEFSIFWKIILPNSAPAVATLAILTFRSQWDNLLWPLLISQSEEMKTIPLYIVKFAMEKHTNEGAMMAAAAIASIPMLILFLALSKYFVSGASLHSSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U0</accession>
    <name>I2F2U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComEA-like protein with helix-hairpin-helix repeat region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730350.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0520"/>
    <dbReference type="EnsemblBacteria" id="AFK06243">
        <property type="protein sequence ID" value="AFK06243"/>
        <property type="gene ID" value="Theba_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0520"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_2_0_0"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="256" mass="27507" checksum="E33D729301416722" modified="2012-07-11" version="1" precursor="true">MRKLTVKELQIIGSVVILVLMGFVAVMGHTGTESTEQNFDQTESVSFPIDLNSCTERELELLPGIGPAKARAIIDYRTSVGQFGSVEDILQVRGIGEKTLSNFRKMVTVAGSATTLADVNTLIDINKADVLSLQDIPGIGEAKAKAIVEFREKNGSFRTSDDLLKVPGIGPSILSEILASIVPLVGSEKQSGSLKVNVNTADEEVLCGLPGVGPVIAKRIVEFRASFGPFRSYEDLERVSGIGEKTIANLKELIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V1</accession>
    <name>I2F2V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent phosphoesterase, PHP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730361.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0531"/>
    <dbReference type="EnsemblBacteria" id="AFK06254">
        <property type="protein sequence ID" value="AFK06254"/>
        <property type="gene ID" value="Theba_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0531"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097071_0_0_0"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="239" mass="26829" checksum="E1CBA23D89110AEE" modified="2012-07-11" version="1">MSFLCDFHIHSCLSPCADITMTPNAIALTCVSKGIDWIAITDHNSARNVRVFSKVLNRFGVVVIPGIEVHTLEDVHILAYFPEVEIAEDYSEWLKGEKFSRLSVDPEISGYQLIVDEDDTFTGFEEIWLGQPALLSISQTLSTVEEYGGVSVMAHIERKMGLLTQLGFIPETCREVPMEISFKRTLEKGLPVENIIHSSDAHSLSMITPTVSIESKARSFEEFRSALYSNGRSLRIIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z6</accession>
    <name>I2F2Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate-formate lyase-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492214.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0580"/>
    <dbReference type="EnsemblBacteria" id="AFK06299">
        <property type="protein sequence ID" value="AFK06299"/>
        <property type="gene ID" value="Theba_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0580"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_1_0"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="331" mass="37510" checksum="6FEA295D7600EE83" modified="2012-07-11" version="1">MKPAVYFDEYGEEKVLQCLLCPLHCIIKPDQVGFCGVRKNVDGMLYSLNYGQLTSIAIDPIEKKPLYHLFPGEKILSVGSWGCNLRCNFCQNWEISKQRPKTVMRVMPQQLIQIALERESRGIAFTYNEPIVSFEFILDTSRAAAKEGIYSILVTNGVIDEEPMDLLSQSVRGMNIDLKGWNDEFYVKDIGTEKRVVLRSIETARKAGTHIELTTLIIPGKNDSPEEMREEAKWISGLSKDIPLHINRYFPNYKSTIPPTSPDSLIQLAEVAKEYLRYVYVGNIDLPGLSDTTCPYCGNLLVERRGMRSSVVGIDEKGRCNNCQKEIPIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F304</accession>
    <name>I2F304_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730395.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06307">
        <property type="protein sequence ID" value="AFK06307"/>
        <property type="gene ID" value="Theba_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0588"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382695_0_0_0"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="23066" checksum="AED41B2D13721A35" modified="2012-07-11" version="1">MKKEKIEYRQSESSDLQFVAHLVFNTDPSHFKRALGTKAQAGISRLLIMGSAINLEFITVCEIGNRPIAIYAFYTHEEMNRLSHLHVDMINFSFSIFGFRLLHEFRTLQRSMEMGIFPEQKYLGLISVHEDFRNKGYGRRILNHLLEMDAEIVLDVSRWNRKALSLYSECGFEFETNLPSNYPTKDSIRMKSTRDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F338</accession>
    <name>I2F338_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730419.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0623"/>
    <dbReference type="EnsemblBacteria" id="AFK06341">
        <property type="protein sequence ID" value="AFK06341"/>
        <property type="gene ID" value="Theba_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0623"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394227_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="550"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="699" mass="76768" checksum="C30A587ED6928CB5" modified="2012-07-11" version="1">MLIENKEQYRANLSSIGDAVLSMDAFGIVTFVNEVACSLIGLSESSTIGKRVSEVMEIFSEDSDEPAIIPVEHVLETGKKVGLANHTALRSKNGKIYSIADSAAPISREDGETTGVILVFKDLTEERKKEGRIIQSEARFQELIENTNGGLLILDSGDGERFILKEFKAPLENLDRTGLGTFGKELRDVFTGVEKSGLFEAVRKVWKTGTPEKVEAEKYVCGDQEGWWTNYVYKLPSGEVDSLCYDVSESLRIQEFKKKTNDGLLTLTKMAAGSGFSLDEFMKSAVRIVGSSLCVYRAGIYMLNRIGEMDLIISFDLVDGEAREDKSRAMDRDLASEYLHLIQAKRFFSISDVNQAEKSNFIASLQEVGVEAILDIPLRIRGIIVGSLFCDMNTARQWSSDEMNFAASVGDVLTLALEEDEPVNSEHRYKSFFKMNGATMLLIDSATGSIVDSNEAACKFYEYDLGTLKGLSIEDLAANNESLVEICNLAAGRSSSVVSRQKKSSEKVVDVEIFAAPFSTENMDLVSLIVVDITEVLAAKNKLSEALGRLHTALEGAVNLVSKVVKARDPCTAGHQKNVSRLATAIAERLGLDDNRSTTVRIAGLLHDVDKVSIPVEILSKPVRLTDLEWSLIKRHPIVGYEILRDVKLGGPIAEIVKNHHDRINGSGYPEGLTVSELSLESRIVAVADMVEAMVSHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F383</accession>
    <name>I2F383_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492335.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0669"/>
    <dbReference type="EnsemblBacteria" id="AFK06386">
        <property type="protein sequence ID" value="AFK06386"/>
        <property type="gene ID" value="Theba_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0669"/>
    <dbReference type="eggNOG" id="ENOG502ZMIS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2369566_0_0_0"/>
    <dbReference type="OrthoDB" id="2060765at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="95" mass="10462" checksum="CDFAB9BBEB910BC3" modified="2012-07-11" version="1" precursor="true">MQAITAKRKPLVREGGKALANSDVWGLFGFLQVLVIFLSLAVSIALPFYFGNEVDKISEVASSREQSISVMKSRLEDVSREISYLQTVVGARAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F384</accession>
    <name>I2F384_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsI/penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0670"/>
    <dbReference type="EnsemblBacteria" id="AFK06387">
        <property type="protein sequence ID" value="AFK06387"/>
        <property type="gene ID" value="Theba_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0670"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_0_0"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="210"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="592" mass="65060" checksum="5140E3003617EC23" modified="2012-07-11" version="1">MRAAYVSLFTEPDLPLVLGVNKIPALRGSIYDSNGRLLASDSLIYEAWLDLGYLRLLTSSDQIDRVLKNVELSFGIPFERLVESLQSNKNFLLLGTAATYDEMQRRITPITKRYISLEMQRERLSFSEYGLERIIGKLDGGGIPLNGIELYYDEELSGKRDGLIRRTLTSSRREEPTNGSDIYLSIDIDIQKMVYDELLETVEKNMADGGLALLVESKTGKILAYAGTYDWDVGLMGIFEPGSTIKPLIYSLALQSGSITETMTFYCDGSIQPVPGLDIIIRDTEGERHGLQTFREAIINSCNVATVQVGGRILNTLGKEEMYRQLMRIGFGKLSGVDLPGETPGILPEAKDWSLISPYQFPIGQGLGVNIFQMVKALNVFPAGGQFITPTFVSAIRNEEGLINIPKKVEGDLFPPKLVSTMLPILEGVVIEGTGTMAKVDGVRIAGKTGTAQKAGPDGYNEESYYSLFYGFFPVEDPTYTLYIMIDTPKAGAYYGGFVAAPMFASVVKNIYGIGVEKEVYEGVYSWKAPDLSGYSLLDLKEIAAIYGLDNIIIHGSGGVVSQIPEAGRPLGDQLEVWLGELNYDIRDVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A1</accession>
    <name>I2F3A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">Theba_0687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730468.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0687"/>
    <dbReference type="EnsemblBacteria" id="AFK06404">
        <property type="protein sequence ID" value="AFK06404"/>
        <property type="gene ID" value="Theba_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0687"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_0"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="13574" checksum="9AE5C6D496DE197A" modified="2012-07-11" version="1">MIQLESYLRVADNSGARMIKVIQVTGGYRKRSGTIGDIVVAAVRDVAPNTDFKKGDIVRAVLVRTAKEIRRPDGTYIRFDDNAAVIIDKQNQPRGTRVFGPVAREIRDKGFSKIASLAQEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B6</accession>
    <name>I2F3B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">Theba_0702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492373.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0702"/>
    <dbReference type="EnsemblBacteria" id="AFK06419">
        <property type="protein sequence ID" value="AFK06419"/>
        <property type="gene ID" value="Theba_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0702"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_0"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="13953" checksum="7F9D4619002AD0A2" modified="2012-07-11" version="1">MARILGVELPNNKKTFVALTYIYGIGYTRSNEILSGTEIDGNKRAKDLTDEEVSKIAKYINEHYKVEGELRTEVDRSIKRLIEIGSYRGYRHRNGLPVRGQKTHSNGRTRKGSRASKIRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E7</accession>
    <name>I2F3E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ORF">Theba_0735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730506.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0735"/>
    <dbReference type="EnsemblBacteria" id="AFK06450">
        <property type="protein sequence ID" value="AFK06450"/>
        <property type="gene ID" value="Theba_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0735"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778296_0_0_0"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040473">
        <property type="entry name" value="NusG_add"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18298">
        <property type="entry name" value="NusG_add"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="2"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="355" mass="40513" checksum="D59686E1AA4689D9" modified="2012-07-11" version="1">MRKKWFIIQTYSGLENSIREAIQIKIESFGFSHMFGKILVPEETKLDRTNVAAEKYIVPANARLLVKDNEDVAKGDPVAEEVEIKVKNDGTVAEVKNYRVIFIETADRRYTKTYYIPESAKIETGIKAGARIRQGMPLAKQGEYFCELDGKIVYTQKMKRIVVDKENGEEDVYLVHPDSYDAKVAKKGNHVKRGQMFGETRRIFSKTEGRVEISDLPGRKEIKIFKITRTRLYPGYVFIEMIMNEETWNLVKNTPNVVNFVSVGGQPVQLKEKEIKALLRLVGIEEYEEHMGGPVKIEVEFDVGEVVRINSGPFEDFVGKVTDLDPDRQELKVVVSIFGRETPVILSLSEVEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I2</accession>
    <name>I2F3I2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730539.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0771"/>
    <dbReference type="EnsemblBacteria" id="AFK06485">
        <property type="protein sequence ID" value="AFK06485"/>
        <property type="gene ID" value="Theba_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0771"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_3_0_0"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="28183" checksum="8773DB448C4A19BF" modified="2012-07-11" version="1">MIDIHNHTTYSDGRNTVEEVIQSALKEGLQIVGISDHFDPYVAQEVCLQPEEVSVYLKEIRTLSEKYPIKVLAGLELGLQSEGILWPGEEMDYFIYSVHTVPGRPDLKTLENPWDIYLQEAISAVDLIDRPGFFGHLDFLRRHIPKAKPPKPGQLMDTLLMKLVSNHVGLELNTSGWMYGIGDPSPQPWVIERYIDLGGRFVTVGSDSHRASQIGNFTVKALSLLRQMGIKEVFYCENGSYIPVPIMEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I8</accession>
    <name>I2F3I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease, DNA polymerase III, epsilon subunit family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730545.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0777"/>
    <dbReference type="EnsemblBacteria" id="AFK06491">
        <property type="protein sequence ID" value="AFK06491"/>
        <property type="gene ID" value="Theba_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0777"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_7_1_0"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="20608" checksum="D48C701A41B8C568" modified="2012-07-11" version="1">MKKIYLVIDTETTGSSPLEGDRILEIAAIPVYGNKILHNLSFQSLVNPLVMIPAQITGIHGLKNEDVLDEPTMAEVFPRFRNYVGGATIVGHNIVNDMTFFDIASKETGILPLANNYIDTIDIAHEVFSEGPYGLKSIAKRLRIRDVPTHRAMDDARVTAKVFLALARRLGGISQMVKYEKKWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S3</accession>
    <name>I2F3S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730614.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0866"/>
    <dbReference type="EnsemblBacteria" id="AFK06576">
        <property type="protein sequence ID" value="AFK06576"/>
        <property type="gene ID" value="Theba_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0866"/>
    <dbReference type="HOGENOM" id="CLU_1862815_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657593" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="137" mass="14859" checksum="41E0F4A135B241F5" modified="2012-07-11" version="1" precursor="true">MKKVAILLVSLVLLCSVSVLASTETRTIFEGGAGPEMLAERSAVNNYRASQIFAVYIHTSGGDVQVAVNGNCSDFCSCASRCLLWQEVCRTAIERGLSLSTSDRVIVFYIEKGVEKVAVLAANEWDFTHDYGTTIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X9</accession>
    <name>I2F3X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730655.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06632">
        <property type="protein sequence ID" value="AFK06632"/>
        <property type="gene ID" value="Theba_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0926"/>
    <dbReference type="HOGENOM" id="CLU_591621_0_0_0"/>
    <dbReference type="OrthoDB" id="776762at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="462" mass="53094" checksum="991E00DBE00B0396" modified="2012-07-11" version="1" precursor="true">MKRLLLLFVIVISVALCAKTGLFLSIYPVLSLNNYTVHDRDYQPGFDDLRTYFSYPAFASAGVEFSGSSYRALFRLDFRQDITSFLRGRSWSNFPIRHNAYTLYIDTDLPRVGFAEFENDFLRISAGKRRLHFGPATYNFVLSETVPYFEHLWLDLGAEVLSGKYFYSFFVISSDRSIFDSPRTLIGHSIGYEGSSTRVGFVETNLISNTFPDLRDMSPFMVFHNNYAKNSNVNAGLFVESRIGILELYGMLYADDILIPGDRTENPTSLGWYLGGEAALIDGNSYVGPVLWDEQFGLREKTLFKESGGLKLKYEHYHSTPYLYNREFEEGKYINPIRFNADDIEGGAYLVINGFYGFPYGPDISLDLLALSYETRRIFTELRIEYIRQGSYRIEDFYGEPFEFDWYRLAQPITGKARLSLNFHYSPDEKQEVTLSASMALGGKSEFSLKIGYGRLFNFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F407</accession>
    <name>I2F407_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730681.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0954"/>
    <dbReference type="EnsemblBacteria" id="AFK06660">
        <property type="protein sequence ID" value="AFK06660"/>
        <property type="gene ID" value="Theba_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0954"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000640_0_0_0"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="32425" checksum="DA8790A53583C873" modified="2012-07-11" version="1">MEFQIFSKALYSTWILYRPERVLFDVGEGISTVLGNSVYAIKDIFLTHGHVDHISGLWGLINTRNTAMGDRNKQLRINFPSGNRAIEAYLDFIIGMNPRLRYNMILNPLNVGDEVYLRTAGSFRRHVTPFKVKHTIGEISYGYHVYEERRKLKDIYGGLPSKEIASVVKEKGREAITDTYLQKIVTISGDTFALPPEVISNSETLLHECTFLVGKDRRNQNHSSIDEVICTVRQSSGIKRLILYHISGRYTSKIKKWHNIIKKELEGTGTEVFLVHPEHVFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F429</accession>
    <name>I2F429_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730698.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0976"/>
    <dbReference type="EnsemblBacteria" id="AFK06682">
        <property type="protein sequence ID" value="AFK06682"/>
        <property type="gene ID" value="Theba_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0976"/>
    <dbReference type="eggNOG" id="COG2461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026706_1_0_0"/>
    <dbReference type="OrthoDB" id="565213at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007380">
        <property type="entry name" value="DUF438"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04282">
        <property type="entry name" value="DUF438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF438" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="87"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="396" mass="46198" checksum="745A4FBBFCB842B5" modified="2012-07-11" version="1">MSELFNKEEFLKGLIRRLHEAPDKLENIREDFVRVVRELTPVEIAQVEQKLVEEGMPPESIQLMCNIHLDVFKEALDEDSLDVGSWHPLHILIEEHRDILNRTKELRDLTGKIISGNYDGEDIRRLQSSIQYLDSLEAYFSKEENVLFPYLERHGLVQPPAIMWKEHDEVRNLRKKMKIEYENLKNGDPNKVNELAITISELFTNHIYKEHKILFPSALKLLSNNEWESIRVEFDEIGYFSFEPMPFVSSEEVSKNNGVEGLVNLGSGFLKVDQLLLMLNTLPFDITFVDENDTVRYFSERKERIFARTRAIIGRKVQNCHPQKSAHVVTRILEDFKNGVRDIAEFWLNLGPKIVHIRYFALRDRSGKYAGTLEVTQEISSIKALEGEKRIYDPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>I2F438</accession>
    <name>I2F438_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">Theba_0985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730706.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0985"/>
    <dbReference type="EnsemblBacteria" id="AFK06691">
        <property type="protein sequence ID" value="AFK06691"/>
        <property type="gene ID" value="Theba_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0985"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_0"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="604"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="802"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="522"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="867" mass="100425" checksum="04114615992477B1" modified="2012-07-11" version="1">MKELSTRYNPSDLEEKWYSCWKEGGFFEPKGSGEPFTIMIPPPNITAPLHMGHALNLVIQDIIIRFKRMKGYRALWVPGEDHAGIATQNAVEKDLAKKGTNRKELGRERFLETTWNWAKEYRQRIREQIEAMGCSVDWSRERFTMDEGLSEAVRKAFVMLYKEGLIYRGKYIVNWCPRCSTVLSDEEVEHEDEKGAFYHIKYPIKDSDEYVIIATTRPETMLADTAVAVYPSDDRYEGLVGKTVILPLMNREIPIIQDRYVDPSFGTGALKVTPAHDPNDFQIGLRHGLEVIEVLDKDARINENGGKYKGLDRYEARKQIVKDLEEQGFLIKVEPMVHAVGRCYRCETVVEPCLSDQWYVKVGPLAEKAIEAVEEGSVTFFPETWKKVYLNWMNEIRDWCISRQLWWGHRVPVWYCDDCNEVIVEEQDPSVCPKCGSKNIRQDEDVLDTWFSSQLWPFTTLGWPEKTEDLESFYPTSVLVTAFDIIFFWVARMIMAGYHFMGEKPFNHVYITRLIRDKNGRKMSKSLGNGIDPLDVIRENGTDAMRFTLAILAAQNHDIKLDVRFFDIYKKFANKIWNAARFALLNMEGFEKVNLDEEELAIEDRWILSRLAKSVKAVEESIDGYDFPSASKMIYSFFWNEFCDWYIESTKPRLNREGRSRIVAQNVLVRTLDASLRMLHPFMPYITEELWQNLPGSDGLLITARWPEFDESSFDNPSEVEYSRIMDMVRGVRNIKAEMNIPPSSKTDVYYIGEVLNQEVVELVSHLSNSNEIDRRAEKTSGSVSAWGDAENTLYVVLGEIDTDAEIERLTGKLEKERVDLARTLSKLENGDFIRNAPEEVITENRERLATSKDNIRRIEKIIEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F488</accession>
    <name>I2F488_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">Theba_1036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1036"/>
    <dbReference type="EnsemblBacteria" id="AFK06741">
        <property type="protein sequence ID" value="AFK06741"/>
        <property type="gene ID" value="Theba_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1036"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="287" mass="31580" checksum="346CD214BDE10EE6" modified="2012-07-11" version="1" precursor="true">MLRRKFSFIYRGVRVMKAAVFYNRTRISAEMLDWLSREIELHKIDTSFCEDRASCSVPEQDVILTFGGDGTVLEAVQMAVLNNLPIMSFRVGSVGFLAAFELSMLHTALDLLQEGKLDGVDRNVMEISLDGTVRYALNDCVVERSTPSRTVSLSVEISGQSSYQVVGDGIIFATNTGSTAYTMAAGGALVDPEANCFQITPICPHNPFVGSIVIGASRKVRMEVKQDKGFPLEAYVDGELVSELRTGETIEVSLSDRKVTLLREGSFDFVALLKRRLAFGGRLKDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E1</accession>
    <name>I2F4E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730792.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1089"/>
    <dbReference type="EnsemblBacteria" id="AFK06794">
        <property type="protein sequence ID" value="AFK06794"/>
        <property type="gene ID" value="Theba_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1089"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_2_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657758" evidence="1">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="69"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="511" mass="57923" checksum="40632982F97EAF53" modified="2012-07-11" version="1" precursor="true">MRKYLVILLLVVVLSFSAFATDKYDSELVVGTDQNPTTMDPAMYQDLASSQVMRNVFETLVAYTADVKEIKPVIAESWTVSDDLKVWTFKLRENVFFQKGKFQDGRNVTAEDVKYSFDREMEISPMVRIYMIDTIEVVDTYTVKITLQYPYAPFLTVLTDIGAAIVPKEEVEGWGDEFVLHPIGSGPYVLKEWVKDDHMSFERYEDYWGEKPYVKNLTYKFIPDKAVLTLALLSGQVDISSDILDQDIPKVKADPNVEAIMVGGNNIYAAYMNATKGPTTDPKVREAIFKAIDVTQIAKVIFPNESGVPAYGPIPPGSWAYNPDVQDFYTPYDPEGAKQILKDAGYADGLKLKMYTSDDPNRRKMAIVMQSMLKQVGIDLEVISLEWGSFVEVSSKGEADIYAIGWTWYPDPEFFMYYMFHSSTAGTYGNGGRYNNPEVDKYIELGESSADQDERIMYYRKAEELVMKDRIFFPGYHKLVVMGVSDKVKGFTVSSDMTIRVFAPGTNVYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E3</accession>
    <name>I2F4E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1091"/>
    <dbReference type="EnsemblBacteria" id="AFK06796">
        <property type="protein sequence ID" value="AFK06796"/>
        <property type="gene ID" value="Theba_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1091"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025379_2_1_0"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="491" mass="54671" checksum="87E43C1E9A4F816C" modified="2012-07-11" version="1">MDDYLGYNKHEYRRTRKLAIIEGSFFNLAFLVTQGFIVTGLALEYGASEMLIAIIGVLPTLAQLVQLAAPLVLKLFKDRKKAMLFSALLGRIPIAFIPVTLALGIRAQSLLLVLLGLIAFGNSLVGTFWASIMGDVIDPETTGKYYGRRNLILSLSTMLITPVYSLILDRYEGSLGFIIVTSMATAFAITTIFLLKMHYAPPVKTFGRGRMFKEVFSNLKFRQYLKFAFVWNFAITISGPFYAYHQLVNLKVSYSYLSILSIVASLTSMLMYVLWGKISDQIGHQSVAEFGILGATCLALMWVFVTPQTAVFLLPVDAIVTGVVWSAINLCLFTMMMGMIRGYSVESYVAVQAFLNGIGALGGSLLGGFIASYLKGKSITIFGMEFFGIQVIFLVGASFRFLSFLLLRRVQTPKIKTVTQVFFNTMSTVGRRMATRPYEFPVLQLRSRKKREEAEPLKLDLPSSMIDLSDIEGIEPEETTDDSDHEERSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G3</accession>
    <name>I2F4G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_1111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730812.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1111"/>
    <dbReference type="EnsemblBacteria" id="AFK06816">
        <property type="protein sequence ID" value="AFK06816"/>
        <property type="gene ID" value="Theba_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1111"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_0"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="53"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="380"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="413"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="624" mass="69883" checksum="94779609A660FB11" modified="2012-07-11" version="1">MSKDSRVHGRGHQGRHGGPMGPGMMRGGEKAKDFRGTLRKLFQYLRKYQILIIVVLCFAAAGALFSIMGPKILGTVTTEVFEGIMAKITGTGEGINFESIARTMLILLGLYVLSALFMYIQGWIMSGISAKVTYKFRQEISQKINRLPLKYFDKSSQGDVLSRVTNDVDTISRTLNQSLSQIITSVTTVVGVTIMMFSISWQLTLIALLMLPVSMGLITFVVRLSQRYFKKQQQYLGKVNGHIEEMYGGHVVVKAFNGEEKSIQTFDKLNAELYDSAWKSQFLSGMMMPIMTFVGNLGYVLITIVGGWFAVRKMITVGDIQAFIQYVRSFTQPIAQIANIMNVFQQTAAAAERVFEFLEEEEEVAETSDPVRGVDHHGHVEFKNVRFGYDPEKIIIKDFSCEVDKGHNIAIVGPTGAGKTTIVKLLMRFYDVNSGEILLDGHNIKEYTRHDLRENFGMVLQDTWLYNASVWDNIKYGRLDATDEEVLAAAKAAHVDSFIHTLPDGYNLVLNEEQTNISQGQKQLITIARAILADPKVLILDEATSSVDTRTEALIQKAMANLMKDRTSFIIAHRLSTIRDADLILVMNEGDIVEQGTHEELLERGGFYAELYASQFESDFVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J1</accession>
    <name>I2F4J1_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06844">
        <property type="protein sequence ID" value="AFK06844"/>
        <property type="gene ID" value="Theba_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1142"/>
    <dbReference type="HOGENOM" id="CLU_2409823_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="92" mass="10754" checksum="AF8224FC27F83DF3" modified="2012-07-11" version="1">MTVGIYWMKQHVFAAGYSRLMSSDVLLVRIPSFREKGTDHRNRSVPIFAYSDQWLLNVCRSLCRDPVQDHYGMTPLNVILTMVLEKFIFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L3</accession>
    <name>I2F4L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730855.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06866">
        <property type="protein sequence ID" value="AFK06866"/>
        <property type="gene ID" value="Theba_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1168"/>
    <dbReference type="eggNOG" id="ENOG5032XVF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846372_0_0_0"/>
    <dbReference type="OrthoDB" id="1578535at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="341" mass="39876" checksum="203956EF8AFBF7AE" modified="2012-07-11" version="1">MQSKTLHGVSILTARNFAQSPSWKCIFDWEDEISNLLFLPLEELTKPRKFSRLLCDPKTFKYALPIVKRIINGCRGKIGIVYLMAPENIRFVLKSKLKLVPIFIDTPTSSYNSLRRLCKVFPFYYVSSYETFEHLSLYHDNVRFLPFSVPETWKLNRIPEKQLDVLQIGRKNPLLHKWMLRMASENGIEYVYQRIEDGVLNYWSTKDGLIGDFRDRRKFAHLLGKARVSLVSSGGIDGSRKGFDINPVTVRFFESAVNYCYMIGRYPPESKDFEYTRMSEIVIRVDDERSFRKQLIKCLDKPFNLKEKYDSIIDSNSTRCIASIIKRDLENYLEKPGLVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M1</accession>
    <name>I2F4M1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730863.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1176"/>
    <dbReference type="EnsemblBacteria" id="AFK06874">
        <property type="protein sequence ID" value="AFK06874"/>
        <property type="gene ID" value="Theba_1176"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1176"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752130_0_0_0"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="57"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="41135" checksum="78F709670E20D1D2" modified="2012-07-11" version="1">MKTLVVGYNHSWKDKRVMRTVETFSKLGHVYYQFSGGIDLSAAQRNSDVQNFSLCRDEMPGTSKVIKRIRFDHEILKMVEELDYDLAYFHSFPASQPVKIFREVKKRGKKLLYDLHEIMPEQFLPERLSFLNPLLWKVLKTQLSLVDGVIGVSEEALRMMFEKTGTEKPMLCLPNYATSGVSPENCVKNAEIAVVGGTHRKISIDSRLLNEIKRNFKLISIGTTCNIADEELPFMDYELMMERISKVKFTLLAFQSRRDPQYANDIYSLPNKFYDSLAAGTPVIIDKRFVSMKEIVEETQTGIILDLLEEPKDPSLILNALDSYGCFLDNLRANYDRFVWDNSKESAFVDFITAILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q8</accession>
    <name>I2F4Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730898.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1216"/>
    <dbReference type="EnsemblBacteria" id="AFK06911">
        <property type="protein sequence ID" value="AFK06911"/>
        <property type="gene ID" value="Theba_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1216"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_0"/>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="7">
        <location>
            <begin position="250"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="366"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="438" mass="47894" checksum="D39EE8DFA760CBD4" modified="2012-07-11" version="1">MKKLFGTDGIRGVINEELTPELAMKLGNAIGRYYTGKYSRFIIAKDTRSSCDLLESAMAAGAASAGMNVEFAGVIPTPALAYITNKEATLGAVISASHNPAVYNGIKVLAKGMKISDEDEVEIENLIIDTPFHYTFYSGVGKISYKDHYRDEYIEYVLGLYRNERLPSDGIVVDGANGAISTVISMVYESLGIGAELRGIEPNGININDNCGSLFPNFLGDSLKKGQIGVLFDGDADRCLFVLPGSKLIDGDMLMALNSRKLVNQGRLKGNRVVATVMSNLGFEKYLTSKNISLDRTKVGDKYVLERMLQTGGVLGGEQSGHIIFLDRSTTGDGLITSLETLNSLEELGESLEEFAASFPVYPQLLKNVPVSNKKLVMEDMNLKNRLEELKQKDDLRIVLRPSGTEPYIRVMVEGAEQLLVEEICQELVELVQECSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R8</accession>
    <name>I2F4R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1232"/>
    <dbReference type="EnsemblBacteria" id="AFK06921">
        <property type="protein sequence ID" value="AFK06921"/>
        <property type="gene ID" value="Theba_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1232"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399419_0_0_0"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="85"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="666" mass="76993" checksum="8B4F2ED50E80E30E" modified="2012-07-11" version="1">MILKEILELLKSKKGKMDYSIPKEWLPDGYSGTLKLRDRYIFVDPYEFGSSIIESIVAKAEPGIDYSKSLGRIRNESDNLWIKSAIVYGSFVRSTAAYSHQDPEFFSDLHSQEYSESGTFLKMIYMLPYLSKMGFDTLYFLPVTSYSDKFKKGELGSPYSVKDFFSIDERYHDFLLEDMDVEREFKAFVEAAHIMGMRIVLDFIPRTSARDSALILKHPEWFYWIDASHLKDYRPPKIEGLGFDQARVETLPVIYSNENVKKHLAMFRYSPEKLNPEKWRNFVAHHEGSDNFLDELVSEFGVITPPGFSDWINDNQPTWDDVTFLRLYKDHPEESRKFLSEDQPPYVLFDVVKSSFFPGKEPMTDLWETIENIMPFYNSKFGVDGARLDMGHALPRELELRIIRKAKENDASFSIIAEELVMGNDEKARQSGYDCILGNTWWMEPRITEGKFKELVYEILPRLRVPTLACVETPDTPRAVARPNGKKFSRFATVLNYFLPNGITYVNSGQEIFEIQPMNLGLDNDEDGRYVLPPNDPFYGKLAFFDPYVLHWNADDDMVDLISLLSSLRRDNLELINPHDLKLLWEEDIESAGLFYWNGSKGLLVVANGDFQSMKDFHINLGYFTWKSEHKVAWKLKGFDGHSEWKVGGDFHLSLGPGEVAVAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T9</accession>
    <name>I2F4T9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lys-AminoMut_A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730923.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1254"/>
    <dbReference type="EnsemblBacteria" id="AFK06942">
        <property type="protein sequence ID" value="AFK06942"/>
        <property type="gene ID" value="Theba_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1254"/>
    <dbReference type="eggNOG" id="ENOG5032S0N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153213_0_0_0"/>
    <dbReference type="OrthoDB" id="1851520at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16552">
        <property type="entry name" value="OAM_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="129" mass="14280" checksum="BB3E3B8E4A285334" modified="2012-07-11" version="1">MMSIQRSDDFEKRSVHLKNLTDEELDRRFWELADKIVEPLIDLAKANTSPSIERSVLLRMGLDSLQAGSIVTKAVEHGLLGKGAGNIVLTYAKMNSLTLEKAVEELAVGKGWEALVSNFRGGDRNVARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U1</accession>
    <name>I2F4U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP-loop superfamily ATP-utilizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1256"/>
    <dbReference type="EnsemblBacteria" id="AFK06944">
        <property type="protein sequence ID" value="AFK06944"/>
        <property type="gene ID" value="Theba_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1256"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885475_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="338" mass="37783" checksum="F065B11A832954F4" modified="2012-07-11" version="1">MRRLLCVILEKMTEQIENSINNTINEIKELAGKDRLTVAFSGGLDSTLVAYLALHALGRDRVKLINVCFGPYSYSRGLEIVASLAERLDLRLEFTPGYEAQENVWKRGPSCNRCTRLAKLPAVRSGVLGLVATGANQSDTWGKTGIVIKDGFYAPLRNWTKAEIEEALSYLNIEVPKIGEAPVREGCKLKHLLKIMAKPSYHGYSVAISNEILLDELDDFSHTLANVKIIGPLSKNVALINVSPLPSERKRGRIATSLESLDSIDEVRWVEGPMVLKIIANPGLFNSPEAREWVLNGRLAPEFAFPIHARWVKSKNNRLETFQVIDCWRLEDDSAHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U4</accession>
    <name>I2F4U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730928.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1259"/>
    <dbReference type="EnsemblBacteria" id="AFK06947">
        <property type="protein sequence ID" value="AFK06947"/>
        <property type="gene ID" value="Theba_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1259"/>
    <dbReference type="eggNOG" id="COG1832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_0_0"/>
    <dbReference type="OrthoDB" id="1910664at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="137" mass="15391" checksum="DCE71E63EC5C130C" modified="2012-07-11" version="1">MIYKENAKKILETFKTVVVVGFSKSPEKAANYVPTYLIEMGFRIVPVNPSMEEYSGLKVYPDLEAVVADGIELEVVEIFRPSEEAESIALKAIELGAKAVWLQKGIYSEKAQLAADENGVLYVEDLCMFEEHRRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U8</accession>
    <name>I2F4U8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">Theba_1263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730932.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1263"/>
    <dbReference type="EnsemblBacteria" id="AFK06951">
        <property type="protein sequence ID" value="AFK06951"/>
        <property type="gene ID" value="Theba_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1263"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_0"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="106"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK06951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="343" mass="39426" checksum="9F54E3BDB54CF94C" modified="2012-07-11" version="1">MKGLDINLQEVLDRVMEISDLNELQEEKSRLTGKQGLITSLMKKLKEIPPEERREYGKTVNEYKNFIEEALNRRKSELENKAKKEREASERLDYTIPGKKRDIGSLHLITQIMEEVQSIWVSMGFEVTVGPEIETSYYNFEALNTPEWHPARDMQDTFYLQDGRLLRTHTSPVQIRTMESRKPPLAIFAPGTCYRKDTPDATHLPMFHQFEILFVDKGVSVSHLKGSLDHFAKRLFGEDRKIRLRPSFFPFTEPSFEVDVSCGICGGVGCRSCGGSGWLEILGAGMVHPNVFRNVGYDPEVWSGFAAGTGLERIAMLKYDLEDIRDLLRNDRRFLRGYRRAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V6</accession>
    <name>I2F4V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter periplasmic binding protein, thiB subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486617.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1271"/>
    <dbReference type="EnsemblBacteria" id="AFK06959">
        <property type="protein sequence ID" value="AFK06959"/>
        <property type="gene ID" value="Theba_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1271"/>
    <dbReference type="eggNOG" id="COG4143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_6_1_0"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657762" evidence="1">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="37135" checksum="1E0027C8F8FE7D14" modified="2012-07-11" version="1" precursor="true">MRRALLLSLMIFFLSLSAVSALTVYSYDSLEPLAEESFGKFTEQTGIDVEFRAVGDSGSLLSLIISEREKFDGDVVIGIDNLLSRRAFEEDIFLSYRPMGFERIISNDLLLDEEWRLTPYDFGSIALICNGSQIEESISTLWDLTKPEFERSVIIQDPRTSSTGLSFLAWTYLLFGERFEEFWRAITPSILTVSLSWDDAFQKFESGEAPIMVSYATDGAYSKHYYGESIYSTVIPEGKGYVQVEGAGIIKWTDNLEEAKLFMDFILSEDFQSHIPLNQWMFPVIEVEMPPAFDYAVKPEKILKLSADVDLSKLIETWEEVIYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y8</accession>
    <name>I2F4Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enterochelin esterase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730964.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1303"/>
    <dbReference type="EnsemblBacteria" id="AFK06991">
        <property type="protein sequence ID" value="AFK06991"/>
        <property type="gene ID" value="Theba_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1303"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024481_0_0_0"/>
    <dbReference type="OrthoDB" id="408919at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="562" mass="63718" checksum="C63BE5B1AB22AEB3" modified="2012-07-11" version="1" precursor="true">MFRKGFVALFVILFVGFTAFSLTFEVSMSQEAIDTVASLGLETPINGRVFVIVSKDSSSEPSMQTDVRGVPFWGKDVFKMTSESVVKISDGDMAVAGYPIDLSDLPAGEYFVQALINVYTTFNRADGHTILMHDDTGDGQWFWESIGNATSKTKKVYLDPANPGSVELAITEVIMPDYDLEPGMVLQQGNYTDTEWVKYVKIKSDVVSEFWGKDMYIGANVLLPEGYYDNPDVYYPVIYYQGHFPGGGAPVGFRVDNDVYKFWTEDGNARFIAVSFRDATPYYDTSYSVDSENSGPYGTAITEEFIPYLESQFRMIPEKWARVLAGGSTGGWEALAMKVFYPDFFGRTYVWYPDAVDFNYYQLINIYNDDNAYYSDFGWVKTERPSARDTHGNIRFTVKQENYYEMAAGPSNRSGGQWSVWESTYSPVGVDGFPQPIWDQITGEINKDVAEYWKENFDLNYILQENWEEIGPKIAGDVHVAVGDMDNYYLNEAVYLLKAAMEKMENPVSDMTFDFGPNQGHGWKGWSPTDPNKALALQEWLLQLSDYMKENVPEGVETDWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F540</accession>
    <name>I2F540_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1355"/>
    <dbReference type="EnsemblBacteria" id="AFK07043">
        <property type="protein sequence ID" value="AFK07043"/>
        <property type="gene ID" value="Theba_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1355"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="25011" checksum="03B54F61A32EC68F" modified="2012-07-11" version="1" precursor="true">MKGRIMVVEDDMHIGKLLRLELGHEGYEVEVLTDGKEALKHLEKELPDLLILDVMLPGLDGFSVLEEIREYISTDLPVIMLTAKGEVKDRIRGLKSGADDYLPKPFVIEELLARIEAVLRRKGKVERISYFEITLDMQSREAFLNGEPLQLSKTEFDLLAVLLSNAGIVMSKERLLEKVWGSEDWGNPNVVEVYINYLRKKLGKTGERIKTVRGSGYVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F564</accession>
    <name>I2F564_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:ferredoxin oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731013.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1379"/>
    <dbReference type="EnsemblBacteria" id="AFK07067">
        <property type="protein sequence ID" value="AFK07067"/>
        <property type="gene ID" value="Theba_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1379"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_0_0_0"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="352" mass="38882" checksum="BB2EE55F5DD88348" modified="2012-07-11" version="1">MAEKIMVKGNEAMAEAAVRAGCRLYFGYPITPQSEFTEYMARRMPEVDGVFLQSESEVAAVNMVYGAACTGHRVMTSTSSPGFSLMQEGVSYIAGAKLPAVFVNVVRGGPGLGDIQPAQSDYFQSTKGGGHGDYHLIVLAPGSIQEAVDLMETAFRLADNYRVPVMMLADGMLGQMMEPVVFPEFVKLEEINDHSSWALRGADGREPHKVTSFDIDPVRLEEMNTETHKVYEKIRSKEIRFETHDLEDADYILVGYGTMGRILGSVVKTARKQGIKVGLFRPVSLWPFPYDELKKAARGKKFCTVVEMSTGQMVEDVRLSVEGSLPVHFYGRTGGMVPTPDEVFRELVRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F593</accession>
    <name>I2F593_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-(Acyl-carrier-protein) synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731041.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1408"/>
    <dbReference type="EnsemblBacteria" id="AFK07096">
        <property type="protein sequence ID" value="AFK07096"/>
        <property type="gene ID" value="Theba_1408"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1408"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_2_1_0"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="259"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="350" mass="38202" checksum="2910D1201AB4B581" modified="2012-07-11" version="1">MTRKPQGVILVSSVPIIGIAGIGTYIPETFMTPEEIADSTGIPQEVIELKFGVKRRLVPGPGETTSNLGIKAARKALENARIDPKDIDLLIWNGAQHKDYPCWLAGLKVADEIGAVNAWSFDMEAMCGSMMAGIDVAKSLMIARDDVNTVLLVSGYRNVDLMDLSEPSTSFMLDVGASGAAVVLKKGHNENVVLSSAFKGDGSFSELCVVPVGGTKKWPMTPEDTRNYHFSVQGDTAEFKKRLGETTMPNFYWVIRESLRKSGFSESDIDYLAILHFKRSAHFAVLEELGLKENQSTYLDYYGHLGQNDQILSIELGLMEGKIKDGDVVVMVGAGLGFVWAATTVKWGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B1</accession>
    <name>I2F5B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731059.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1428"/>
    <dbReference type="EnsemblBacteria" id="AFK07114">
        <property type="protein sequence ID" value="AFK07114"/>
        <property type="gene ID" value="Theba_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1428"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_0"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="383" mass="41274" checksum="231D6CC47F132C49" modified="2012-07-11" version="1">MITKPGDLREKNMGRVIQLLLANPDISRVEIARKTELTKTTISAILAALLDLNIVEETPGLKTGLVGKTPIPMRVRGDAAVAIGVNLARGSTSGVVMTASGELLESVSKEVSNLTRADATAHLFEVVQRLLNKCFRNGIDVDAIGIGVPSPLDKEKGVIYAPYGLSDWKDFPVGEITREKFGLPVFLVNDADGAAFGMKCFGKCRDIRSFISMYFDEGVGAGIILNDEIYGGSSGYSGQISYALIKSFCNGQVENSRFSLDTVVSDLNKEIGVSCGKIDDFLDRRFNGGQKMNSVLSRVGDELGRIAALVSNIVGPEAVVVNGRLLDFGKVFFSALKDSFESNLFSRGSVQLIKGFTNQFRAFSTGAASYAIFSYLMDKVLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B2</accession>
    <name>I2F5B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731060.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1429"/>
    <dbReference type="EnsemblBacteria" id="AFK07115">
        <property type="protein sequence ID" value="AFK07115"/>
        <property type="gene ID" value="Theba_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1429"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_0"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="47092" checksum="F52F1FE63E393D33" modified="2012-07-11" version="1" precursor="true">MKRKVVLSLLLVVLIGVSSFGVVTLNFIEVLTSPARTQVIKEIIADFEAKNPDIKINLISPPYEQADQRATLMLNTNQPLDIIEVRDYTVKQFVNNGKLENLESYLAGWEHNDTLTFVANQAARTVDNTAFIVPQFFFIKGLFVRTDILEKLGVSYIPKTMSELVELCIDITDPEKNQYGFGFRGKSWEFKFSDLIATSFLSDIDATNIYKTKSGEAYFDDPRAIEGIKMYVRLFEGGVPADGINWGFNEQVNAFVSGITPFLIQDPDTVALVDEMLGREYYTVVPIPVGPSGKAYMDYGFSGLGIPSYSKHKEQAWEFIKYISSPEVNAYFSKSYGPLPIHSSTYENDPYFSSGVYTAWSYMMSHPEKYIFASYPLDSEKWPGWPEIHQQDMQSLLLGDTTVEAVAAKWAEYWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B9</accession>
    <name>I2F5B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1436"/>
    <dbReference type="EnsemblBacteria" id="AFK07122">
        <property type="protein sequence ID" value="AFK07122"/>
        <property type="gene ID" value="Theba_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1436"/>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879292_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="340" mass="37315" checksum="542693C842F37C6A" modified="2012-07-11" version="1">MRMEGAAMRYEGEYTVFDTSNVKVYSLLDRPSEVSISDLIDIKEIVNESDGFRSPELEELSGKVLEAKEKGLPVIVFCGAHVIKNGMGPLLSSLMHEKIITALGVNGAFTIHDFELAYCGRTSESIPNALSRGLFGFAEETNKYINNALIHGNKLFLGYGESMGRLLSGEAFPEKIDCMYPEVSVQYNAYRDSIPLCVHSAMGTDIYHMTPYFDGESLGGCSARDFLIFANEISKLEKGGVCIVIGSAVIGAEVVLKAISMAANVGRPPKLITTASFDIRDADLDEASKNNKEVASYYFRDVKSIVTRIPNAFGGKGYYIKGNHKETLPSFYRLIMKGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G2</accession>
    <name>I2F5G2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">Theba_1482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731096.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1482"/>
    <dbReference type="EnsemblBacteria" id="AFK07165">
        <property type="protein sequence ID" value="AFK07165"/>
        <property type="gene ID" value="Theba_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1482"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_0"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
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        <property type="entry name" value="DnaJ_C"/>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="DnaJ_domain_CS"/>
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    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
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        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="218"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="40814" checksum="28BBEDF6AF0809A2" modified="2012-07-11" version="1">MAQSRKDYYEILGVSRNASDDDIRKAYRRLVKEWHPDAYKGSNKKDAEAKFKEIQEAYEVLSDKEKRAMFDRFGYVGDAAANPRGSGRTPGSTGGSFDDVFGDFQDVFDVFFGGSRSGGSSKTQGPRAVRGEDIHASVVIDLKDVILGKKVILEYDRNKVCQSCKGTGAEGGTSFKTCPTCNGTGYVKEEHRSFFGMFSNTHVCNTCSGSGRIIDKRCSVCGGRGYEKERHQVSVTIPAGVENGATLRIGGHGNAGQNGGPYGDLYVSVRVEMPSEFRRSGNDLYVSKEIDYVEAALGTTLEISLPEGGTEILRIPAGTNPNTVFRMKNLGVPSVSGGKRGDLLVTVRVNISKPSSKEKRLLEQIAKLKNSRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J6</accession>
    <name>I2F5J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1523"/>
    <dbReference type="EnsemblBacteria" id="AFK07199">
        <property type="protein sequence ID" value="AFK07199"/>
        <property type="gene ID" value="Theba_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1523"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_2_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="187" mass="20995" checksum="A551D6ED1C9B0CE3" modified="2012-07-11" version="1" precursor="true">MVILFIVIGIIVVLALWLIGVYNNLVTLKKRVENAWSQIDVQLKRRHDLIPNLVNSVKGYMKFEQETLDKVIQARAKAVSAQGVGDKIKAEQELGGALGRLLAIAENYPDLKANTNVSQLMEELTTTENKISYARQFFNDSATKFNTKIEIFPNNVIVGFFGGKFESFPLFEVTEAERGTPNVDLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K0</accession>
    <name>I2F5K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487119.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1527"/>
    <dbReference type="EnsemblBacteria" id="AFK07203">
        <property type="protein sequence ID" value="AFK07203"/>
        <property type="gene ID" value="Theba_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1527"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_0"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="9">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="7">
        <location>
            <begin position="92"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="8">
        <location>
            <begin position="262"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="366" mass="40838" checksum="662265FE53965806" modified="2012-07-11" version="1">MKRYFVAPGRVNVIGEHTDYNQGFVMPVAIDKYVLLSIERTDESVIALSSAGREPVSFREESIEKTGDWSDYLKGVFWVLKDNLGVDFGGMKIKISSSIPEGAGLSSSAALEVALILALNSVYGLKLGDKELYSFAQQAENEFVGVQCGIMDQFAAVMGKKDTAIFLDTLEMRHEYVPLELGEYTFVVFDSKVHHSLSSGNYNTRRAEANKALEILGKNSYREVSMIDLFPNRGKLGDLYYRRALHVVSENMRVLEAMKMMSNSNFENLGRILIQSHESLALDYEVTCEETDFIVDTLREIGGVSGARMIGAGFGGSVLALCEKIEMKKIVEVMKIRYKERFGIDLDSYEVRPSDGAREVDATFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K4</accession>
    <name>I2F5K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487125.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1531"/>
    <dbReference type="EnsemblBacteria" id="AFK07207">
        <property type="protein sequence ID" value="AFK07207"/>
        <property type="gene ID" value="Theba_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1531"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_4_0"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="224"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="674" mass="78212" checksum="DCEACD7AB6C5063A" modified="2012-07-11" version="1" precursor="true">MMLVKKMMIILFLTVMTLGCGVSFLTTSESTPSVVVMEKSMTLEMMRLENDWWTAEVSLEPGRYRYYFTTEESSFPDERNDEKSYENEREMSVMIVEDFEVLHDSVRHSVGDRDYLNPINHDEYYFAVSAPTDVPFEAKIVIDGERYPLEYLRDFGNQSFYRTERLSVEELEYYFEIQTDSGLVFLDSLGLCRKPRIPYCFSKESLPISYFDLPDWSKGATYYQIFPERFANGDPRNDPPNVQEWNADPDYANLGGDGFFGGDLKGILDHFDHLLELGVDAIYLNPIFESPSSHKYDTEDYLKIDDNFGDDQLFEELLTAANDSDVKIILDGVFNHTGYDFFAFKDLRERGEESPYVDWYFVKRFPIRKVQDRAMTYVGWNGYAYMPKINALNKDWQSYVERLVRKYDCDGIGGWRLDVATEVDPLFWTDFFRPLLKSLDDEMILVAEFWGDARSLLRGKSFDSVMNYPFKDAVVEYVFRAGNSAAKFAAMTNLYLNAYPPQTLHSLWNILDSHDTERILTLAFNQIDLMKIAVALQMTFIGSPVIYYGDEIGMKGGRDPENRAPMIWDEERWNHDVHDFYKALLDLRRSHESIRTGEYEVIAAEGPVFSFRRWKATDEVIVITNPSREAAFFSPSMEGEFTEYLTGETISFFGGEIKVPPLTVWILTPRDSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L9</accession>
    <name>I2F5L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487151.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1548"/>
    <dbReference type="EnsemblBacteria" id="AFK07222">
        <property type="protein sequence ID" value="AFK07222"/>
        <property type="gene ID" value="Theba_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1548"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_0"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="385" mass="43991" checksum="02333DE266D86059" modified="2012-07-11" version="1">MNIAMFSDTYSPQVNGVVTMIKMLEENLQKRGHNVYIFTVDHPEAGIQENVYRIPSLKFPWEKQHRIGLPTNFKELIKIVKNLEIDIIHSHTSLIVGYLASYVLTNLHIPGVTTYHTMMEEYVHYIPFMEPILRVYIRAQDRRFCDKHRAVIAPSIKIKKLLLSYGVSSHIEVIPNGVDLTPFKRSFSREEKRAFRKKYKIKEDDKVLIFVGRLGEEKSIDKLIENFARVSEALPDSHLLLVGDGPLKGKLQELARSLRVGEKVHFTGFLRWPDEISLAYKSSDAFMIASHTETFGLVTLEAMASGLPVVAYKDDSIVNMVLDGENGFMCSSKDELSNAAIQMLSDHSLRERMAKRSVEISEDFSAEANVERTVNLYERVVKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q3</accession>
    <name>I2F5Q3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731162.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07256">
        <property type="protein sequence ID" value="AFK07256"/>
        <property type="gene ID" value="Theba_1588"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1588"/>
    <dbReference type="eggNOG" id="COG3328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036805_2_0_0"/>
    <dbReference type="OrthoDB" id="792870at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="404" mass="47128" checksum="1BB5D5024CCEABAA" modified="2012-07-11" version="1">MKFDREKIKSLIEKNGFEDVGDVQEAMKELFGDVIKEMLEGELEDELGYSKHDYKNKETDNSRNGHSKKTVRSDYGEIELEIPRDRKGEFEPVVVKKHQRDISGIEDQIISMYARGMTVRDIQSHIEDIYGSRLSAESVSRITDKILPLVSEWRNRPLESAYAIVYMDAVFFRVVESNQVRKKALYIALGVSLNGHKDILGMWISETEGASYWLSILNELKNRGVEDVAIFSIDALSGMEEAIEAVYPFSEVQKCIVHQIRNTMRYVTWRDRRPLARDLKTIYQAPTREAGWNALLALEEKWGDKYHLSIKSWKDNWETLSTFFQYPEELRRLVYTTNPIESVNRQLRKVTKNKGVFPTDNSLLKMAYLAIMNITKKWTVRTLDWSRILTQLVIKYERLAKYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R9</accession>
    <name>I2F5R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR type III-B/RAMP module RAMP protein Cmr6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731171.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1608"/>
    <dbReference type="EnsemblBacteria" id="AFK07272">
        <property type="protein sequence ID" value="AFK07272"/>
        <property type="gene ID" value="Theba_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1608"/>
    <dbReference type="eggNOG" id="COG1604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053305_2_2_0"/>
    <dbReference type="OrthoDB" id="1359321at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010172">
        <property type="entry name" value="CRISPR-assoc_prot_TM1791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39965">
        <property type="entry name" value="PTHR39965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01898">
        <property type="entry name" value="cas_TM1791_cmr6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="251" mass="28739" checksum="0ECDFE3A1C6D6496" modified="2012-07-11" version="1">MVDPKTIANRTIKNSSLNYDKLFPISKHSMTDTSQLSSLLQILMNRFSYCDRDSVRSLLERRDRIVTSFRKVLDRELQTKKYLMVGSGCPSIFDNGFTLMRNYGVPYIPASAFKGAFSHYVSQELEENSPLKQNFKFLFGTGEGDDNIKGALIFMDVIPKTYSLGIDIINNHFQPYYSDDKNEKAPNDYYDPVPVQYLVIANGSIFRFSVLEKEKIEDNLRKEVSRELINFLGDFGLGAKTSYGYGLFKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5U5</accession>
    <name>I2F5U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1635</name>
        <name evidence="2" type="ORF">Theba_1712</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">MesG1.Ag.4.2</strain>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1635"/>
    <dbReference type="EnsemblBacteria" id="AFK07298">
        <property type="protein sequence ID" value="AFK07298"/>
        <property type="gene ID" value="Theba_1635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07369">
        <property type="protein sequence ID" value="AFK07369"/>
        <property type="gene ID" value="Theba_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1635"/>
    <dbReference type="KEGG" id="mpg:Theba_1712"/>
    <dbReference type="HOGENOM" id="CLU_1904246_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="133" mass="14639" checksum="CE00623DA9AE5944" modified="2012-07-11" version="1">MLPAESGITYALGLLGERRTFDGGPERLPAGGILAGMFFSSPASKSPLERGDRLRWGVCSSLKTPFHKVLQPERRGCLSSRQRTSLPDSAGLEFLRNFRRHSARDSEDGGPLTDNAVFISNQRVFDFKRTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F630</accession>
    <name>I2F630_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1649</name>
        <name evidence="4" type="ORF">Theba_1726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MesG1.Ag.4.2</strain>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731207.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1649"/>
    <dbReference type="EnsemblBacteria" id="AFK07312">
        <property type="protein sequence ID" value="AFK07312"/>
        <property type="gene ID" value="Theba_1649"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07383">
        <property type="protein sequence ID" value="AFK07383"/>
        <property type="gene ID" value="Theba_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1649"/>
    <dbReference type="KEGG" id="mpg:Theba_1726"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_0"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="309"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="603" mass="68694" checksum="759308FD16E4A252" modified="2012-07-11" version="1">MKVFKNGNLMVVTDDRGIIDCEYEKAAGLYLEDTRFISRMILKSSHKLRRLHTDFSWDRIETHYLGRSKPGIPHYDIAVSECLRAEGNALQTELTVRSYSLEEVRISFEYDIICVFEDIFSVRKKNDSYNELESSRTLSSSPPRSFQYETDLERDTVENSLTSLSLEVRPGQIERVSGKLRLGKYVKKDVVFKKMLSERPVKDIAPIKKTSLLDERELGDLKMLMIPTVYGDFPGAGLPWFATVFGRDSLIFGLQTVDLLPEITRNILTVHTHLQSKEEDSQTEAQPGKIVHETRLNELSLAGRLPFERYYGSIDATLLFIMLSHRYYSQTNDWNFIRSIKNSIMAAAKWIDTYADLDNDGYIEFAPSGTGLSIQSWKDSADSVSFSDGTLAEPPLAPVEVQGYLYDAFKCLEKLMALFEDEERANVYALKAAALKENFNRDFWLESEDYFATALDKNKKPVDSITSNPGHCLMTGIVDEDRAEALVNRLFSDELYTGWGIRTLSSKMKRYNPFSYHNGSVWPHDNSLIMLGLIKYGFYEKARQLARDLLKVKDKHHDNRLPELFSGLSVSETSGKLIEYPTSCSPQLWSIGTVLVISKALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F687</accession>
    <name>I2F687_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731271.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1789"/>
    <dbReference type="EnsemblBacteria" id="AFK07440">
        <property type="protein sequence ID" value="AFK07440"/>
        <property type="gene ID" value="Theba_1789"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1789"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="356" mass="40016" checksum="715D281ECF57015D" modified="2012-07-11" version="1">MKMNANVCERLRSPVMKKTTIKDIANELNISPSSVSRALSDEPGVSPSLRKEIVDAAERLNYIPNSSAKSLKTRKTQTVGLIVSDIRNPFFLDFMSGVETVLFPRGYKFIVCDIGEDFEKERIYIKWLLEHGVEGILSSPCGGEDGRNNSRLYREAVRRNIPVVFYDRILEGLDRISSVTLDNRQAILQGVLHLKENGHRKLGIVLHKKGIYTIEERRMGFLEACKMLDIEINADWIIENAVDAERASLSLESVLKSDRRPDAIISTNQFLNEVIVATVRRMGLKIPGDLSIVGFDDHSMNELIEPPLTTIRQPVKDIGRIAATIMLSEIDGTRGDKSKVVLKAELLQRKSVSKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F691</accession>
    <name>I2F691_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07444">
        <property type="protein sequence ID" value="AFK07444"/>
        <property type="gene ID" value="Theba_1793"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1793"/>
    <dbReference type="HOGENOM" id="CLU_2771106_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="69" mass="7805" checksum="3782C0261048BB9A" modified="2012-07-11" version="1" precursor="true">MAFKDYHIISLIMTIVFVTFYGTLLAGIGDSEESNIPIIKQNQLRTTLEGPTCGESFDRLYMALLFIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C2</accession>
    <name>I2F6C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731299.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1824"/>
    <dbReference type="EnsemblBacteria" id="AFK07475">
        <property type="protein sequence ID" value="AFK07475"/>
        <property type="gene ID" value="Theba_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1824"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164772_0_0_0"/>
    <dbReference type="OrthoDB" id="1403983at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="27596" checksum="EB243C32F46B9F30" modified="2012-07-11" version="1">MREEDLKRAILEAWSKRLGFSSDRFFLGTYFFFPDESKRGKGGIEQLSFERQTVILYDPLLEDVFKSIETQDENPGDYLADLIRDSFLLLKKTSIKYLNPSNYVPFYPPTEFSVRRLNQGDRTAFYRFRNQCTREDLAEGFVELDHVAVFGALYEDEIVAVSSIIVWDEIADIGIITMPDFRELGLGKALGSRASEWAVINKKLIQYRHNVLNYGSLKVSRALGFREYIVDQEYSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M2</accession>
    <name>I2F6M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731377.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1929"/>
    <dbReference type="EnsemblBacteria" id="AFK07575">
        <property type="protein sequence ID" value="AFK07575"/>
        <property type="gene ID" value="Theba_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1929"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101297_0_1_0"/>
    <dbReference type="OrthoDB" id="1852220at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658371" evidence="9">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="18852" checksum="C0138CAA2BAF97A4" modified="2012-07-11" version="1" precursor="true">MKAKRYVFPLVMAGFVSAVFAANNQVGRNALSITGTSFLEMLSVIPPIFILLGLLDVWIPREKITKHLGEESGIKGISLSFLLGAAAAGPLYGAFPIAAVFMKKGVKFSNVLIFVGAWSTTKIPMFMFEMGSLGAGFALLRLAINIPGILLMAIILERITGKESIDAICAQAASISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N9</accession>
    <name>I2F6N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731392.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1947"/>
    <dbReference type="EnsemblBacteria" id="AFK07592">
        <property type="protein sequence ID" value="AFK07592"/>
        <property type="gene ID" value="Theba_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1947"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="119"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="346" mass="38776" checksum="958DE0BD6684065B" modified="2012-07-11" version="1" precursor="true">MYWKYAIKRVLYGILMYAILVFIFSALFNTVMEQTLRAQIEEQIRGETMRMTSLNESQLEDYVINRRNDLYSLYRLTRPVAERILWRTWDTLTLNLGNSTIIRSSNGSRSVWDVVSEAIPKTILLFSVAMLVDIVLGLLLGLKKAQKAGGLLDKSTSVGTMVVFGMPSWWLGMIMIMFFAYGVKIFPSGGLHSTPPPEGISYFFDLLYHLALPVLTLVVIGFWGRAFLTRNIVLGVLQEDYIMAARARGIPERKVLYGHTMRTSAPPIVTMSLLALLASVGGNIVYEGIFSWPGMGNLYWIALQQNDVPVLMGNLAITTGLYICGLVLLDLIYGLLDPRIKVGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R9</accession>
    <name>I2F6R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731414.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1979"/>
    <dbReference type="EnsemblBacteria" id="AFK07622">
        <property type="protein sequence ID" value="AFK07622"/>
        <property type="gene ID" value="Theba_1979"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1979"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060714_0_0_0"/>
    <dbReference type="OrthoDB" id="632656at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="382" mass="42526" checksum="EC0F2E15F1DFE631" modified="2012-07-11" version="1" precursor="true">MMRKLLILVVLTLIVLAGGIPLYIQRSYKEEVVAGPSVTDVFKLSKYFDGIKGTIADTDVFELKGAEEGGKTLIIAGTHANEPSAALLAYFFIENLEVEKGTIYVIPHFNRSGSLGPQPGGGFPLYYFVDTPWGEKKFRMGDRGFQALDQWPDPDVYVHYPDGQLLSYIDARNTNRSWPGRPDGYLAEKVSFAAMEMIRNEGIDVVIDLHEAEAMYPVTNCIVAPEKSMPYAIGAAFYVKGREKFENHVESSPAGYRGLSHREIGDWSDAYPFLLESPGVHLDQITAAKTPELIIDGIDPFVLKAGEKGLLFVPYDENGFSMDRRVGQHSSVIQEILSQWTKKNPDRGFKVSAPKHADIVENGLGFYFKDPSEADEDKVFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S8</accession>
    <name>I2F6S8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0316 protein Theba_1988</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0316 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731423.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07631">
        <property type="protein sequence ID" value="AFK07631"/>
        <property type="gene ID" value="Theba_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1988"/>
    <dbReference type="eggNOG" id="COG4843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106166_0_0_0"/>
    <dbReference type="OrthoDB" id="1480783at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01515">
        <property type="entry name" value="UPF0316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044035">
        <property type="entry name" value="DUF5698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022930">
        <property type="entry name" value="UPF0316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40060">
        <property type="entry name" value="PTHR40060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18955">
        <property type="entry name" value="DUF5698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5698" evidence="9">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="194" mass="21782" checksum="97E2AC71148508CB" modified="2012-07-11" version="1" precursor="true">MEEFLSGDLFKWVIMPLIIFFARIVDVSLGTTRIIMVSRGKKEIASLIGFFEVIVWLLVASKVIQSVDNVLYILAYAGGFAAGSYIGILIDERLAMGTVSIRLITSVEPTELINKLCQAGFGVTKIDAQGSRGKAYIIYSIINRKEVSEFERIAQECVPKAFMSVEDIRKVREGIFLPRDTLRLRKESPLRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U5</accession>
    <name>I2F6U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731432.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2005"/>
    <dbReference type="EnsemblBacteria" id="AFK07648">
        <property type="protein sequence ID" value="AFK07648"/>
        <property type="gene ID" value="Theba_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2005"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_0"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="59"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="278" mass="30126" checksum="3D8F8AEB363ADFA3" modified="2012-07-11" version="1">MLIDRITKLIFGIISYTLVAVILAIIGFLVINGLDDISLEFLVSFPRNSMTEGGIWPSILGTFYFLSIALLFSVPVGILSAVYLSEYSKENRFQRLVLTANNILAGIPSVVFGMFGLSLFSITFGFGTSIISGGLTLGIMSLPYIISNTHESLAAVPKSYREASMALGANKAETTFRIVVPASFSRILTGVMIAVGRIIGETAPLLFTGAAFYITRNPSGLFEPAMSLPTHIFVLSAIYPENVTPKLEGSISVLLIIVITLFVSVAIRRRIESKKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U9</accession>
    <name>I2F6U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+/Co2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731436.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07652">
        <property type="protein sequence ID" value="AFK07652"/>
        <property type="gene ID" value="Theba_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2009"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_8_1_0"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="35682" checksum="79BFAF97B8295E0C" modified="2012-07-11" version="1">MREILISENGRMNTIDSPVEGCWINVVSPDSGDIAFLKSLEIDEDFVYDALDQEERARFEQDEDLIYVITKLPYLDTADETVPYKTTTLGIAMKSGYFVTISSSENAIVSDIVEGRVKDISTKKRNRFLLRIFDRATVYYLRYLKEIRRLSNEIESELHRSTRNQELVAMLNLEKSLVFFTTSLRSNELMFEKLKRANILTLYEEDEELFEDISIENRQAIEMANIYSDILTGMMDAFASVISNNLNVVMKILTIVTLSLQIPTLVASIYGMNVKLPFMESSTIFYWSMGLSGLAAFLVGFVLFKIRWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V8</accession>
    <name>I2F6V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2018"/>
    <dbReference type="EnsemblBacteria" id="AFK07661">
        <property type="protein sequence ID" value="AFK07661"/>
        <property type="gene ID" value="Theba_2018"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2018"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="156" mass="17702" checksum="B59053186CD98348" modified="2012-07-11" version="1">MAEISLGKNVPDFSLLDQNGNEISLSHFSGKKIVLYFYPKDNTSGCTLEAEGFRDLASEFEALNTVIIGVSKDSLKSHQSFSLKLDLNFSILSDENGRIHEMFDVIKPKKMYGREYMGTERSTFVINENRILAKEYRNVKAKGHAVEVLEFIRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X0</accession>
    <name>I2F6X0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucrose-phosphate synthase</fullName>
            <ecNumber evidence="3">2.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:22172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57723"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731454.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2030"/>
    <dbReference type="EnsemblBacteria" id="AFK07673">
        <property type="protein sequence ID" value="AFK07673"/>
        <property type="gene ID" value="Theba_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2030"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_24_2_0"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016157">
        <property type="term" value="F:sucrose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046524">
        <property type="term" value="F:sucrose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044161">
        <property type="entry name" value="SPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000368">
        <property type="entry name" value="Sucrose_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46039">
        <property type="entry name" value="PTHR46039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00862">
        <property type="entry name" value="Sucrose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sucrose_synth" evidence="7">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="6">
        <location>
            <begin position="248"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="482" mass="55340" checksum="32B4C694FBBAB28C" modified="2012-07-11" version="1">MRVAFINPQGNFDREDSYWTTHPDFGGQLVYVKEVASAMSEMGIRCDIITRRIIDERWPEFADEFDYYPGKENLRIVRIPFGPDGFLRKEDLWPYLGEFSIRIIEFYRAERTMPNFLTTHYGDGGLTGAMLFKETGIPYSFTAHSLGAQKLDKLLQTGENRMKIEEEFKFSYRIAAERISMKYSAVNFVSTSMERFQQYSHPLYREFSDVGNDSKYSIVPPGVNTDIFTANPSELDEAIEDRYKEAVERFSNASRFRLPMIVVSSRFEGKKNHIGIVRAFANDRELHESSNLVIVTRGIKNPYEEFDSLEEPDRSVLKEIIDHIRRNGIEYGVIFLNIENQHELSALYRISTKRKSIFALTSLYEPFGLAPIEAMACGLPVVATSNGGPAESLREDNIEYGVLVDPLETNDIVRGLKKALFSSPSFWEELSSRGVDRVTEKYTWRSSAENYLNVIKEKIKGEYPEPEIPECLYSGDGLPFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X4</accession>
    <name>I2F6X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731458.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07677">
        <property type="protein sequence ID" value="AFK07677"/>
        <property type="gene ID" value="Theba_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2034"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_12_0_0"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="32944" checksum="961878C7E2C55020" modified="2012-07-11" version="1">MGFEVAVIGAIGIDTNVYLSGSEIDFSVEATFTEVVDCIGQAGGYVCQSLKRLGHEVCFIGYVGSDYFGDHIRETLSAQGIDIAFLGVDPLGTKRSVNIMYKNGERKNFYDGRGAMALKPDAEAIKKYLFGTKLAHVNIVNWSRFLLKPLREAGLVISVDIQDVTDPDDLYREDYVREADVLFFSSTNFRDPTPIISKYLRVRNDRIVICGMGKRGCALGTEHGINFFGPVELDEPVVDTNGAGDSLAAGFLSSYFLEGYTLEESILRGQIAARYCCSKKGVSSDLITKEQLDEAFAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z7</accession>
    <name>I2F6Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487935.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2062"/>
    <dbReference type="EnsemblBacteria" id="AFK07700">
        <property type="protein sequence ID" value="AFK07700"/>
        <property type="gene ID" value="Theba_2062"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2062"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099015_0_0_0"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043101">
        <property type="term" value="P:purine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="201" mass="21785" checksum="2CEC82EDF05D4037" modified="2012-07-11" version="1">MDEVVLSRQEIFSSFEEAVRNKGSVLGNGILRVDSFLNHQIDPQLMKNAGELIADYFRTYGVTKVLTAESSGIAPALMAASSLGAQLVFARKSRPITMQRYLSESAPSHTKGGIVELNVSLDYIDEKDRVIIVDDFLASGKTIEALARLVLKTGASLHGFAAIIEKTFEEGRTLLAKFGVPVLGIVRISSLDPLSFVKNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F761</accession>
    <name>I2F761_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731532.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2130"/>
    <dbReference type="EnsemblBacteria" id="AFK07764">
        <property type="protein sequence ID" value="AFK07764"/>
        <property type="gene ID" value="Theba_2130"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2130"/>
    <dbReference type="HOGENOM" id="CLU_1711087_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="17175" checksum="97CD5B9FC943F897" modified="2012-07-11" version="1">MDNVLALFPGGSTGLFGSKVYDVVLIPEGIMLVQLTRELTNEAIKKAKDASEERKEGFFKKMASVMSSGYSLLDRYNEKTKEEILNETPGNLFIPKESLRKIKVSSNTNSSQGTSSDSTVIKIVWNEGKIKLTFRTDLNERKVKRVFEETFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A2</accession>
    <name>I2F7A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731570.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2172"/>
    <dbReference type="EnsemblBacteria" id="AFK07805">
        <property type="protein sequence ID" value="AFK07805"/>
        <property type="gene ID" value="Theba_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2172"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_0"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="19545" checksum="9CEBE95D4D622EEA" modified="2012-07-11" version="1" precursor="true">MILLNLFWSFFKIGFLAFGGGYGALSLIQDQIVNVNKWIGIEEFLTLISISQMTPGPIAINSATFIGYRIAGVQGSILATIGVVLPSVFWIFLILKILKILSKWIDTAEVFNALRLGIIALILSATLRIGIESINSVFTIVTAVSAFYILYKFKLSVIWIVFGTGILGVFWSFFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E3</accession>
    <name>I2F7E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731606.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2215"/>
    <dbReference type="EnsemblBacteria" id="AFK07846">
        <property type="protein sequence ID" value="AFK07846"/>
        <property type="gene ID" value="Theba_2215"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2215"/>
    <dbReference type="eggNOG" id="ENOG502ZPMS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2717114_0_0_0"/>
    <dbReference type="OrthoDB" id="2092022at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="8738" checksum="4E80C63AE96E77CE" modified="2012-07-11" version="1">MKVLKSGVPEFEAKMFQEILLKEGIFSELVDSHFAYTDSVYFGSGGLVDIIVPDEVFDEAVQIFEDLKKTGREEMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F0</accession>
    <name>I2F7F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2223"/>
    <dbReference type="EnsemblBacteria" id="AFK07853">
        <property type="protein sequence ID" value="AFK07853"/>
        <property type="gene ID" value="Theba_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2223"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053995_0_0_0"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="365" mass="41842" checksum="295780DB2BB34588" modified="2012-07-11" version="1">MKVQDAKHLSKIIMESGEIPLLWGHFGVGKTDLAREIASETGRELIILVISQMEPGDLIGMPSRDGERTLFLRPDWWPTEGNVILMIDEVNRAHRSIRNAIMQLLIDRRIHNHFLPEGSWIMAAANPPDEEYDQVELITDPAFMSRFFHIELTPDPDEWLKWAEIQGMPSNVTNFIREYPEFLSRDTIVSMRLELRPSPRSWYKLGRVFADLSSEEIERYGYVIAAGIVGPEAARTFMSKIQGSELLPSPRALLLDLDENILGRLSEGDISWTSASVLRVTKHLSELDDLQVQEYFQNVPLIAGNLLRIGKVIPKDSFFSVIRHIVHQVEGEKGLKRAFYENLLEELAMDHDVLKFLQRSEKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F3</accession>
    <name>I2F7F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731615.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2226"/>
    <dbReference type="EnsemblBacteria" id="AFK07856">
        <property type="protein sequence ID" value="AFK07856"/>
        <property type="gene ID" value="Theba_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2226"/>
    <dbReference type="eggNOG" id="ENOG5033C44">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1584541_0_0_0"/>
    <dbReference type="OrthoDB" id="2039124at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="168" mass="19047" checksum="D774708EA6CF4279" modified="2012-07-11" version="1">MARQTLKMFYPISIKNIRKLKAGDLIEYTGQVLLADETTVDKYRTYERLEGTPFYNLSRELILFCTPSEGRLSSDSVKIDLDDLEYLFMSGITATVGLNVEEEEITALYKRFSRVNLSLCNRTSLYPVDLNEPVPDEVECGMSISLKDVLLYVDISSRGTKFGSEEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G4</accession>
    <name>I2F7G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2237"/>
    <dbReference type="EnsemblBacteria" id="AFK07867">
        <property type="protein sequence ID" value="AFK07867"/>
        <property type="gene ID" value="Theba_2237"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2237"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_15_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01541">
        <property type="entry name" value="PBP1_AraR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033532">
        <property type="entry name" value="AraR_ligand_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="356" mass="39849" checksum="CAA30A5969F39192" modified="2012-07-11" version="1">MEATVITPKYSVIERFLLEELKSGKYSVGDKLPTEKELMKKFSASRETVRKALDRLSFEAAIVRRPGLGTFVSYGSDNHLVGILVQQITSYIFPYIVLGAEDHLFRNEYKMLLGNSAEDPVKERQILSEWIASGVKGLIIDPVYSATKRSNKDLVKSMAKSGVKIVLVHSDWNIDQVSCNVLDDAFGGEKAAEIFFEYGHKRVAVIYKSTHLPGVIRAKSFVDRCRQLGFSKIYEKSFNVSEFTGAPMQIAHELMSLPQQIRPTAIFCYNDATALQLQLVAKRLALNIPEDISVIGFDDGPIGDFRDVLTTFAHPKEDVGRRSVEILLDMLNGSKAYRVVHKPELIERSSVAGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M1</accession>
    <name>I2F7M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07924">
        <property type="protein sequence ID" value="AFK07924"/>
        <property type="gene ID" value="Theba_2296"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2296"/>
    <dbReference type="HOGENOM" id="CLU_1473561_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="183" mass="20897" checksum="6156FF0E96EF8A4E" modified="2012-07-11" version="1">MISTPLSKKSVRKKPFREFTNLLMRGIEIEKPVTFGGESGLCRKAKWGLTSSIRPADRREVPSFVQNHESVLREDWFFVPTLRVQVVRSWNRSRIKSGMTINGYSEKARFRSSDKAPGRNLDTIASRLSSVNGEPVCLIFRDLRPISLDFSTHNSHWNLQLILAHSNHRPAIPTTPFESFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S7</accession>
    <name>I2F7S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731728.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2357"/>
    <dbReference type="EnsemblBacteria" id="AFK07980">
        <property type="protein sequence ID" value="AFK07980"/>
        <property type="gene ID" value="Theba_2357"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2357"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_0"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="64"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="251" mass="27727" checksum="79AA21FEDB4D1853" modified="2012-07-11" version="1">MQSVERIVKILSSFSLEESRLSLDDLTKKSGLPKATVYRIAEALCKEHVLKKDSQTPTYRIGIKLFELGSLYLSSMKLKDVAFAEMEKLHLQTGETIHMGILDGTEVVSIEGFESFKSLHTKLYIGKRAPLYCTAVGKAILAFLPEADREGLIDTLDLIPQTSKTITDKAKLREELERIRSRGTAFDKGENEDGIACVGAPIFDSSGVVVASISISGPIFRMEEEVMKKYSDLLKKVVSRISSALGHGLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V7</accession>
    <name>I2F7V7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein Theba_2392</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731752.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2392"/>
    <dbReference type="EnsemblBacteria" id="AFK08010">
        <property type="protein sequence ID" value="AFK08010"/>
        <property type="gene ID" value="Theba_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2392"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_1_1_0"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="33380" checksum="FE93EE918411736B" modified="2012-07-11" version="1" precursor="true">MSSNIFVVTGMSGAGKSSAIDVLEDFGFFCMDNVPPSIIEELVNIIGAQEIDKSAVVIDIRTAKKFGGIERVNQSLKSLKQKGLGIVSIFLDAEDDVLYYRYQKTRRAHPLQEETGLEEAIQKERSIMDPFKKNCDHVIDTSRMDMKEMKEAIVSIIRGKGYKLPPMRVEIESFSYSEGIPHDANLIFDVRFLPNPYYYEDLIELTGMDKKVKDYLETYPEIETYFSTVLKLCRMTIEGFAGSGRNFMKIAIGCTGGKHRSVYIADRLFEELKTDNLRLSLDHREQKVHKDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y5</accession>
    <name>I2F7Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731776.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2423"/>
    <dbReference type="EnsemblBacteria" id="AFK08038">
        <property type="protein sequence ID" value="AFK08038"/>
        <property type="gene ID" value="Theba_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2423"/>
    <dbReference type="HOGENOM" id="CLU_1990017_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="125" mass="13242" checksum="1187E5CEFF577128" modified="2012-07-11" version="1">MPTPSGSDAPKSISGSDAAAQEVMPGVSSGEVRPLSAGSIQEPVKRRESSPPVKASPLPVPLRGASFSFKLRPVNASSGKNNRKTQLMQNIRTVALRASSGSREKSRCALKRKNPLVAERKNSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F884</accession>
    <name>I2F884_9BACT</name>
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        <submittedName>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFK08137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK08137">
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        <property type="gene ID" value="Theba_2533"/>
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    <dbReference type="KEGG" id="mpg:Theba_2533"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_4_0_0"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="324" mass="34654" checksum="EECF8BDE4D24962F" modified="2012-07-11" version="1" precursor="true">MALKNLFKKGLKAENLIEVLPYLLLVGIFVVFAILYPPFSRIRNITGILTVSSVFLLVAAGETFPILMGSIDLSVGAMLSSCAIVAAYFFPQGGLGMIVLAIVVGFLSGLINGLLVVLLKLPSFIVTLAMMYVYVGIATGLTNGYNISIRNRDFAWISTGQMIEGIPNVIIWAFIVFAVFVFISRKTVVGRYILAIGSNEESVKKMGINTNKYRIIAFTFSGLLVGIASVLLSSYLGMAPARLGDKYLFNTLIAVVVGGTSIMGGSGGLLKTLIGVLLISMFDNGMSLIGSTSNVQNIAKGILLIAAISLVMLPHRRGRLLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A7</accession>
    <name>I2F8A7_9BACT</name>
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        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2560</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2560"/>
    <dbReference type="EnsemblBacteria" id="AFK08160">
        <property type="protein sequence ID" value="AFK08160"/>
        <property type="gene ID" value="Theba_2560"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2560"/>
    <dbReference type="eggNOG" id="COG3752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_3_1_0"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="257" mass="29771" checksum="68E05D70523DCFCD" modified="2012-07-11" version="1" precursor="true">MTYVILSSSLVVLAYMSLFFAIGTLKKDNSVVDIGWGAGFVVVALFTLFVYGEFNARQVITTVLIAFWGIRLTTHIFKRNWGRGEDFRYVQMREKWGEKVLIRSFLQIYMLQGLFMVIISYSVMLINSHSGRSFGFLDVLGILIWVCGFSIEAIADKQLRDFVKTKKPGEIMTKGLWRYSRHPNYFGEAVQWWGIFVIALSIEGGIWAIISPITITILLRFVSGVPYLERKYKQYPAFREYMKETNAFVPWFPRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B5</accession>
    <name>I2F8B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, permease component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2568</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2568"/>
    <dbReference type="EnsemblBacteria" id="AFK08168">
        <property type="protein sequence ID" value="AFK08168"/>
        <property type="gene ID" value="Theba_2568"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2568"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1488093at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="32776" checksum="C0D06F1A7D0B2750" modified="2012-07-11" version="1">MKSKRNLTGFLISMPGVLWLTVFFLIPYLIIILYSFLTPGIYGGVELPFTLAAYTRMLGSAGYWQILWKTVWISLVSTVICLGIGLPTAYFIATSKRSNILLTLIIVPFWTNFLVRIFGWMVILGRNGVINSFLQLIGFDRPLTLMYTPGSVILVISYMYLPYMILPLYSAIEKFDFSLVEAAMDLGAKRTEAIMKVLIPSIRGGIIAGIILVFIPALGSYAIPDLVGGTDGAMLGNLIAKQLTAARNWPSSSAISMIFLLISTLGLLVYMRINKVQTKRRLTVRESYMNEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B6</accession>
    <name>I2F8B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ORF">Theba_2569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2569"/>
    <dbReference type="EnsemblBacteria" id="AFK08169">
        <property type="protein sequence ID" value="AFK08169"/>
        <property type="gene ID" value="Theba_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2569"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK08169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="42532" checksum="21FA4B7BABCAC5F4" modified="2012-07-11" version="1">MKEYSVVLSNVTKIFDDSFTAVDNVSLTIEQGEFFSLLGPSGCGKTTILRMIAGFEDPTFGNITLNGKNIIGTPPNEREVNTVFQNYALFPHLNVFENIAFSLRLRREPEDQVRRKVKEMIELTRLNGHVEKMPSQLSGGQKQRVAIARALVGRPTVLLLDEPLAALDAKLRQHMLVELDTIHDEVGITFIYVTHDQSEAMSISDHVAVMNEGEIIQLGTPFEVYESPVNAFVANFIGETNFFTGNVVKVEDEYFLLDTEKFGEIWFYKDMEVIEGQEIQVSLRPEKVKVTRDMPVAPEGVKLNVLKGVVDETIYLGNQTKYTVAIGQSYLKAFKQHVRYLFDEVIITWKDDVYVWWFADDSYVLRETGGVPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C6</accession>
    <name>I2F8C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731897.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2579"/>
    <dbReference type="EnsemblBacteria" id="AFK08179">
        <property type="protein sequence ID" value="AFK08179"/>
        <property type="gene ID" value="Theba_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2579"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_0"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="5">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="332" mass="35856" checksum="00812278279E9288" modified="2012-07-11" version="1">MSDLLVIAERRGNEIHSSTFELLGKARELSIKRPLTVSVVVLSDKPVEEDSANSLFSGGADRIILAVDRSFSRFNFEPYTKTLASIVREFAPEIVLAPATTSGRTYMPGLAALLKTGLTADCTGLDIEEETGNLLQTRPAIGGNIMATIKTPNHRPQMATVRPKTFSALKEAYESKSELVNFEVTPDLTQTEAKLIEFHPIGAGQKGVQDAEVIIAGGMGLRKVENMEPIFRLSKMINGTVGASRKIVDSKWIGHEAQVGLSGHTVKPKIYIAAGISGAVQHIAGMQTAEFIVAINRDRNAAIFNFADIGLVGDAVEILNELAKSLESEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E5</accession>
    <name>I2F8E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489423.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2598"/>
    <dbReference type="EnsemblBacteria" id="AFK08198">
        <property type="protein sequence ID" value="AFK08198"/>
        <property type="gene ID" value="Theba_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2598"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="36501" checksum="AC34B102557F21A2" modified="2012-07-11" version="1" precursor="true">MSAILEVKNLKTYFRTPDGLVKAVDDISFYLEKGEILALVGESGCGKSVTVQTILGLIKVPPAKVEGEILYKGKNLVGLSNKAYRDIRGKEISMIFQEPMSAFDPLYTIGFQLTEVARAHMNWDQTRTYDEIISILRRVNIPEPEKRYREYPHEMSGGMLQRIMIAMALITNPEIIIADEPTTALDVTIQAQVLNIMRELQGEFGSSIIFITHDLGVVAELADRVHVMYAGKIVEKAGVKELYSSPSHPYTKGLLSSRVTRSFKGKKLPYIEGYVPRAYEFPEGCRFNPRCPHAMEICRQKDPPEFYVGDGHTAACWLFEGGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E7</accession>
    <name>I2F8E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489421.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2600"/>
    <dbReference type="EnsemblBacteria" id="AFK08200">
        <property type="protein sequence ID" value="AFK08200"/>
        <property type="gene ID" value="Theba_2600"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2600"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_1_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="322" mass="36079" checksum="5787F1578C0DB362" modified="2012-07-11" version="1" precursor="true">MWSFIARRLLIMIPMMFFISVICFVITELQPGDFISQYLDNPRISPAQIELLRKNLGLDEPAHIRYWNWIKGIVTRGDFGYSFAFQRPVGELIWERMGWTVFVALGAIVFQWILAVPMGIYSALHPYSFGDYSLTVIGFIGLSVPDFFLALILMYLMLQMGATSVGGLFSPQFVGAPFSLEKFVDLLKHLWIPLVVVGMSGLAGLMRVMRGNMLDVISSPFVTSLRAHGLDEKTVKRHAIKNALNPMVSIAGTELPNVFSGTIIAAIVLNLPTMGPFFYNALLNHDQYLVMTFLMFIAIITQIGNLFADIALAVLDPRIRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H6</accession>
    <name>I2F8H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="1">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxT</name>
        <name evidence="4" type="ORF">Theba_2629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731936.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2629"/>
    <dbReference type="EnsemblBacteria" id="AFK08229">
        <property type="protein sequence ID" value="AFK08229"/>
        <property type="gene ID" value="Theba_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2629"/>
    <dbReference type="eggNOG" id="COG0311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069674_2_0_0"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="1 3">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="1 3">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1 2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1 2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1 2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="200" mass="22220" checksum="4B0EA93D8DBED50E" modified="2012-07-11" version="1">MKIGVLGIQGAIQEHLSILRNAGVEPSWVKDRKELNSVEALVMPGGESTTMIKLLKRFEMWEALRNRIEDGMPVLATCAGMILLSKKIENVVNQDSLGVLDISVKRNGYGRQINSFEVDLQIDEIGPEPFRAVFIRAPKIESIGGEVRVLTSYDGSPVLVRQNNMLAASFHPELTGDLRIHRYFLKMVEAAGQSIEKCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L8</accession>
    <name>I2F8L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2672"/>
    <dbReference type="EnsemblBacteria" id="AFK08271">
        <property type="protein sequence ID" value="AFK08271"/>
        <property type="gene ID" value="Theba_2672"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2672"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2409825_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="92" mass="10758" checksum="37929A5E3FA3412C" modified="2012-07-11" version="1">MIVTVVDIQVKSEFLDKFIEATRENHKKSVSEPGNLRFDFLQDKADPSHFFSMKPMNPRKQLQITRGQIITSDGRKELRSTWRDHAGELKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M9</accession>
    <name>I2F8M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2683"/>
    <dbReference type="EnsemblBacteria" id="AFK08282">
        <property type="protein sequence ID" value="AFK08282"/>
        <property type="gene ID" value="Theba_2683"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2683"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056531_1_0_0"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="32176" checksum="4503076EDD8FB371" modified="2012-07-11" version="1">MVSSLSVFTRKVKDLDKKIRILCVQPHDKSTIEAIRSIAESNSKIEVTMYGSFEKISEITPAEFLKEVQIVEGEMEEENVSRAAASVNGKTPAVLMKGNINTAVFLRTLFRSENVKIAGRLISHVSCMEIPDHPKLLFITDGTVNVAPDLREKAEILRNAAGFARSIGLKCPKIAVIGINERISVTNRDLIEAAVLSKMAERGEFGECLVDGPMPLDTALKKEAALNKGIQSEVGGDADILVCSNLESAANLIKGLAHLGKSRTAGLLIGTGFPVVLTSRSDDEFAKMASLSIAIVSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N1</accession>
    <name>I2F8N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isopropylmalate/homocitrate/citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731979.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2685"/>
    <dbReference type="EnsemblBacteria" id="AFK08284">
        <property type="protein sequence ID" value="AFK08284"/>
        <property type="gene ID" value="Theba_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2685"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_0_0"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="417" mass="46448" checksum="0FBDC37B16E38E68" modified="2012-07-11" version="1">MKPKDLEYMKLNGTPYFDDSRWVCPLNYENKIRGKDAKDSIYIHDVTLRDGEQTCGLTWNEDQRVRIGVALNELGVKSIEVGMPIVSDENKRAIRRLVDMKLDSEIVPFARSLKKDIDESLDCGATRVVIEHAVNPYDNELVYGVSPEKLVDRVVSAILYAKEQGMKPTFMGWDATRSSFDYVLKIFTEVAKQAKPESMVFVDSFGVASPFAIEFIFTELRKAIPNIPFEFHVHNEFGLAMGSVFAAVRAGVSGIHSSINGLGERTGNVATEEVAAGLKLLMGIDTGIDLSKIGYTSRLVEDISKIQVANNKPVVGKRLFWVESGIVVDAIDKLNKAGINAAMTPYLPSLVGMGEIQVKLGAFSGQASIKYWLKRLGIEANEDQIEELTEIVRKEGRIRNTVLEIDEFKRIVGDFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N7</accession>
    <name>I2F8N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type branched-chain amino acid transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731985.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2691"/>
    <dbReference type="EnsemblBacteria" id="AFK08290">
        <property type="protein sequence ID" value="AFK08290"/>
        <property type="gene ID" value="Theba_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2691"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_0_1_0"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="372" mass="40087" checksum="09B6721A27ADB0A1" modified="2012-07-11" version="1" precursor="true">MRLNRLLVVAIVLLIGVAALGSTIKVALVAPFTGLGSILGDYIKMGAQLALEEINAAGGINGDMLEMVVYDDAANPSTAANVIRRALFQDKVVAVFGPNMSSSVIGVHQLAQQAKVPMLVGATSPSFRYSVIPNDFLFRLRADDKVKVIQLVKYAVEELGIEKPGVIYGSTDYCLAALDVAKEEFPKYGIEIVAMEQIKEGDKDATGQLLKLKNAGFDGLIGLTHESEAAVTVNQLRQLQIDVPIIGFSAWGVPAFTDLAPEAAIGVYSVQGFNPIDPDPAVQAFVEAYKARWDGKEPSDPGQAYYDGMYLLADALKNVGTDGTKLAEYLANEANIVGVQGELKCDEHHNFTNVCLISQFDGKDWQIITKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q3</accession>
    <name>I2F8Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731999.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2707"/>
    <dbReference type="EnsemblBacteria" id="AFK08306">
        <property type="protein sequence ID" value="AFK08306"/>
        <property type="gene ID" value="Theba_2707"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2707"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142799_0_0_0"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="156" mass="17991" checksum="5F12E192B4625559" modified="2012-07-11" version="1">MKLLTKNEKITIDRFENMETAEREIGIDRIVDFLHTHLEEYGDDRKAIWRSIEYAFSNEAGKGGFVLIARHGERILGASVVNDTGMKEYIPEHILVYIAVDREARGIGIGKKLIKQIKRTCNGDIALHVEENNPARFLYKKMGFKTKYAEMRFAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G4</accession>
    <name>I2F1G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein Theba_0012</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729950.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0012"/>
    <dbReference type="EnsemblBacteria" id="AFK05767">
        <property type="protein sequence ID" value="AFK05767"/>
        <property type="gene ID" value="Theba_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0012"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_1_0_0"/>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="121" mass="13367" checksum="2407E791A3071ADF" modified="2012-07-11" version="1">MAKKFRGLGGRNYGGSRKGSNMGDLLKQAQKAQEEMENLEDSFKSIEVTASAGGGAINVVATCDYRIKFIEVEPEIREEDFEIVQDLIIAGINEALAEVTKRREEETAKITGEFNLPDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G5</accession>
    <name>I2F1G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729951.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0013"/>
    <dbReference type="EnsemblBacteria" id="AFK05768">
        <property type="protein sequence ID" value="AFK05768"/>
        <property type="gene ID" value="Theba_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0013"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_0"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="331" mass="35869" checksum="87F378F5D87D04DC" modified="2012-07-11" version="1">MHKVGINGFGRIGRLVFREMVKRGEFDVVAINDLTDAATLAHLLKYDSVHGRFKGSVEAKEGAIVVNGKEVKVFAEKNPANLPWKDLGVELVIEATGVFRSREKTMPHIDAGAKKVLITAPAKGEVDATIVLGVNDEVLKPEMKIVSNASCTTNSIAPIIKILNDNFGIEKGYLTTVHAYTNDQRILDLPHSDLRRARTAAANTIPTSTGAAKAVGVVIPELKGKLDGIAMRVPVTDGSITDLTVVLKKDTTAEEVNELVKKAAENELKGIVEFTEEELVSSDIVGTTVSAIFDSKLTAVMGNLVKVCSWYDNEYGYSCRVVDLAKKMMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G9</accession>
    <name>I2F1G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">Theba_0017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729953.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0017"/>
    <dbReference type="EnsemblBacteria" id="AFK05772">
        <property type="protein sequence ID" value="AFK05772"/>
        <property type="gene ID" value="Theba_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0017"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_2_0"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK05772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="30850" checksum="4BBD9F3532694658" modified="2012-07-11" version="1">MRSRLRIGVFDSGIGGLTVLKRLVETLPEGVSFHYFADTARVPYGSKPVETLRRYVREIFDLFAHLNVDAIVTACNTSDSILTQSDKAELGVPYFSIIDPTVRRIGESAPGNSTVAIIATENTVKKSLYLRKLFRYESFSKIVQKACPLFVPLIEEGIWEGEIVDSIVKYYLNDFAEIEPDFMILGCTHYPFIKNSIERFLPSKTKVVDPSEYIVRDVADWATILSPEPSTVDYYVSGNTRIFQDILKRYLGRFENVKGVDLNVTGINVRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I6</accession>
    <name>I2F1I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729966.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0036"/>
    <dbReference type="EnsemblBacteria" id="AFK05789">
        <property type="protein sequence ID" value="AFK05789"/>
        <property type="gene ID" value="Theba_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0036"/>
    <dbReference type="eggNOG" id="COG5513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085048_1_0_0"/>
    <dbReference type="OrthoDB" id="1624082at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="233" mass="26432" checksum="509A844467E347BA" modified="2012-07-11" version="1" precursor="true">MRRLLIAVYLVFALAVAFSYTEDLPEQIFLSNGNMISVLGKNIVEDSEICEINIQIPSISGLKDKPFEDYLNATIESEITDYRTQIEEMAQAAYEESKTSEWPFRKFSIYVLYEAYLSDGILSIDMIFSEYTGGAHPGASRRTYNISVDRCRLVALHSVLDSAAAEDRLNELITGEIGKREDLWPEYFKGVTTDQGFYLKAGRLCVYFQPYEIGPWAAGMPEFCFSLGELLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I9</accession>
    <name>I2F1I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ORF">Theba_0039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729967.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0039"/>
    <dbReference type="EnsemblBacteria" id="AFK05792">
        <property type="protein sequence ID" value="AFK05792"/>
        <property type="gene ID" value="Theba_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0039"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_4_1_0"/>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="276" mass="29826" checksum="CB26EDB4F32F50C9" modified="2012-07-11" version="1" precursor="true">MRVGIIGVGNIGGIFADRLLGELEGLEKLYLLDRNQERLSNYSGETERVVIAKTPGEVLENCTHVIISVKPQDCMELFAEVINGKNSSPIIISTITGIEIALISRKTGLEKIARIMPNVPSAIGRGVTGFVCSSSLTGREKKEVERILRTMGEIVEVREKDLSAVTALSGSGPAFVFVIVESLIDVGLKMGLSYDVARELILGTLGGSVELLKVKGNHPGEFRHLVTSPGGTTIEGIYSLEREGLRGTIMKALFDTYLRAEEINSELEVTHNGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J9</accession>
    <name>I2F1J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AICAR transformylase/IMP cyclohydrolase PurH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729977.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0050"/>
    <dbReference type="EnsemblBacteria" id="AFK05802">
        <property type="protein sequence ID" value="AFK05802"/>
        <property type="gene ID" value="Theba_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0050"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575942_0_0_0"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="474" mass="52992" checksum="23AF956945A426D0" modified="2012-07-11" version="1">MNIKRAFVSVHDKSRVEKIAGYLVSNGVEIIATDHTAEYLIDHGVEAIKVADYTGFPSIFDGRLKAIHPKIIGGILAIQDLPAHIEEMREHSILPFDMIVMNLKPFESAVKESPDESNLSKEIDISGPALLMAGAKNHRDIVVISDPMDYDEVIDSLEDCGDVPLLKRRRYALKAIYAALLYNSSIHKALSQIFASEKYDYTVMEHVMQLLYGDNPSQKAHLLKLSKEPGLLDEVQIGNPAIGLKKSQLRNINVFMELYYYSDNISLFLDKGKIIKVFAGKVPDDFSTGGPDTMFASTFAIDGDTLKRLSDDGVEAFGGVFDRDAIRAARERDIMILTVPVHEAVTLSKETYSGFGNYFVRELTFEMKKYDLDTDGRLALYCSRVNRANNFSVFKDGESLLLKSGLSYEELQSYDFGSHDLRDSVMASDNDLTDDLIVRILASGVRQIILPGTKRTYSNRSILVLGIDFTRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M7</accession>
    <name>I2F1M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730003.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0079"/>
    <dbReference type="EnsemblBacteria" id="AFK05830">
        <property type="protein sequence ID" value="AFK05830"/>
        <property type="gene ID" value="Theba_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0079"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_15_1_0"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657559" evidence="1">
        <location>
            <begin position="26"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="418" mass="45943" checksum="45898E20528292AC" modified="2012-07-11" version="1" precursor="true">MKRGVVLLTVLCLLFAGATALGSSANELVVYHWWTAGGEKEAIDALFEVFIDEHPEYSIVQNPVAGGGGGILRAQIKTMIMAGNPPDTFQITYGHGMISSFVSVLQPIDDLIKGYNIPEDVYEWGRVDGVMYGVPLNLMQNNCLWYNVDLVEELGIEMPIKSLDEFLGVCARVKAEGYVPLAVGAGMGQQFWLGTLFEAVNSALSGGGADFFVDYYAGKTTPSESEVFIETLKVLRTLIVNGFVNDDWSALTWDQASDLMATGKAVFYVMGDWAKGHFTSMNMVPNVDFGYQPFPGTDHVFIGHADCFVLPIGVDRKIAKDWIQFLTTVKAANTFCPIKGAAPFVLDAPLDVYDDITKEILGYFRDDGVAKVLSQFGAPPESYLDVFGTAFSEYFNSPEINENTLGNFDYAYEEVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M9</accession>
    <name>I2F1M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730005.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0081"/>
    <dbReference type="EnsemblBacteria" id="AFK05832">
        <property type="protein sequence ID" value="AFK05832"/>
        <property type="gene ID" value="Theba_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0081"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="31091" checksum="A771F869A45DD34F" modified="2012-07-11" version="1" precursor="true">MSRARSKSISGVVDITKKGIIYLLLLAAAFFYLFPIYTAVNTSLKSNQELAYGPVNIVRNPEFANYLKAFSEIDKPIWNSFVITMVATAISSALGAWGGFGYSKLKFRGSSVLFLILVLGFYIAPQSILIPLLRFIGSIGLYNSYWGLILTHTAYGVPITTLLFRNYFESLPTEVVDSARIDGCSYIGTFFRIALPLSLPGFAVVAIFQFTNIWNEFLFGLILTRGADSQPLTVAIGNLKGTTVASWNIQMAGMLISVLPVLIVYIFFLKLIVKGLLMGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q1</accession>
    <name>I2F1Q1_9BACT</name>
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        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">Theba_0105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730021.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0105"/>
    <dbReference type="EnsemblBacteria" id="AFK05854">
        <property type="protein sequence ID" value="AFK05854"/>
        <property type="gene ID" value="Theba_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0105"/>
    <dbReference type="eggNOG" id="COG2930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_4_1_0"/>
    <dbReference type="OrthoDB" id="1808930at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658613" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="96"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="222" mass="23920" checksum="B5FDFD8D7D65F1EC" modified="2012-07-11" version="1" precursor="true">MKKLILVVIMMASFSTFGASLPKERIQNALGVLQELTQTEDSGSFIELLSKSNGIVIYPEMVKAALGFGGQFGEGFLLKRAEDGRWYGPLFLKLYGISYGFQAGVQKSGLVFVIMNEKGIEGFLGNNVTLGGSASISAGPTGKTLSADTDYKLEAAIYSYSVSNGIFAGVSLGGSIIRQDSDTNREYYGLSLTPQEIIEKEAIGDDVNELINFLESLIVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q2</accession>
    <name>I2F1Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490187.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0106"/>
    <dbReference type="EnsemblBacteria" id="AFK05855">
        <property type="protein sequence ID" value="AFK05855"/>
        <property type="gene ID" value="Theba_0106"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0106"/>
    <dbReference type="HOGENOM" id="CLU_1538285_0_0_0"/>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="174" mass="19355" checksum="BA03514C3E9B52CF" modified="2012-07-11" version="1" precursor="true">MKFDSRKSLIVVLVNLALLTILAVSSCGEKPNPAEEKLTLSREEILALCGLEESEISFTKIKLDVSGKPLLTVAAYDGEGRQIFSKDFPQSEVKGGYVTVAVIKSEIIDALRFLYAVTDSKGSVFSFVQDLPYFQYQEVKVEKGDYSHISSKGEFRLISVTFGQEKQDIFLNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S6</accession>
    <name>I2F1S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730044.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0133"/>
    <dbReference type="EnsemblBacteria" id="AFK05879">
        <property type="protein sequence ID" value="AFK05879"/>
        <property type="gene ID" value="Theba_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0133"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055424_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="213"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="412" mass="47120" checksum="A425F26D0FF6EBAC" modified="2012-07-11" version="1" precursor="true">MKGFDELRYIRPTQVIFIFAVTVVLMLLPYHIFQNEAIDYTQKIYSGIFETSVENLASALSVGYFQRSAMYDAVSSGDEEFVEEMLQEIQQDFPGVRSARLIERPPDVPLKDQYKLSNIDQELYLYFNIYDSLMENEVSDRVVIARIDKDVLLSEMHLDERVSLTSGGSKSFAYGLRAEVEGYDLTKWLIFHSLTAGILGVLFMMEVLALGLSRYYEMHGLQEIMYLWELEDSYTAFHSKNVSKIAGLLGKKLGLSRKKIQQIVNGAKLHDIGKIGISQKILRKRGPLDEIEREVIQGHPAHGKEILEHFKYLQQFIPYVYMHHEREDGSGYPQGLKGDQIPLEAKILAVADVFEALTANRSYRDAYSFAKAVEMMTEMPLDQGIVSALIEILPELETELSGRNPEKCWERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T0</accession>
    <name>I2F1T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730048.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05883">
        <property type="protein sequence ID" value="AFK05883"/>
        <property type="gene ID" value="Theba_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0137"/>
    <dbReference type="HOGENOM" id="CLU_2494281_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="86" mass="10317" checksum="FFB20BD73C3C2FFA" modified="2012-07-11" version="1">MPEIQDIEIIRVMWRDYHGKKDYYVTILGRNVVSREYVTFESRSFTDQDIDELKTTLVEGRKVRISSENGISFLEVNHFRLYESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T5</accession>
    <name>I2F1T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exonuclease of the beta-lactamase fold involved in RNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730053.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0146"/>
    <dbReference type="EnsemblBacteria" id="AFK05888">
        <property type="protein sequence ID" value="AFK05888"/>
        <property type="gene ID" value="Theba_0146"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0146"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_0"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="239"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="443" mass="50194" checksum="A9DF1A0A781FF8D2" modified="2012-07-11" version="1">MTLTPLGGGREIGANSYLLSLDGKNILIDAGRHPVKEGYESLPEIDKINDLDVIMISHSHYDHLSSLPYISQRWPNAPILMAQENKGLALRILQNSVEVMKKKNAKDGVEPILYNHGEVNELKRRIYPMEYFQRYSIDDVVDVALYPAGHVMGAASIFLEHRGRRILYSGDISLSQQLTIPPAQLPKKVETLISEGTYGAKENQLLTRYSEIERLSKSVKRVLENGGRILMPVFALGRGQEAIYMLLMLMEKKKIPSVPIYTNGMVASLSSLYMSNYESISEKDRKWFIKSFQNNVTVAPKSIERLLFSREPALFVFSAGMLVEDTLSYIFAKQMLPNSKDAIFFMGYQSPESDGYKILQANKNGDERIQMGDDSIEIGTKNIDIFNFSGHADYQELLDLPRRLQPEKLIYVHGDEAALENLAEELQYEFEIQIPSNLQTVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T9</accession>
    <name>I2F1T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730057.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0150"/>
    <dbReference type="EnsemblBacteria" id="AFK05892">
        <property type="protein sequence ID" value="AFK05892"/>
        <property type="gene ID" value="Theba_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0150"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="278" mass="31783" checksum="F12AC301E6821EEF" modified="2012-07-11" version="1" precursor="true">MKRSTKKKVKKSITYSLLIFLSVVIAFPFVWLILTAIKTYPDIYAYPIKYFIFEPTREHFDKIADMNFWSYFKNSVIVGTGTMFFSILIGLFPAYAFARYEFRFKRPLLTGVMVFQMLPVVVFLLPIFKTLNNIGILNTYFGLILSYLPFTTPISIMFMRTFFLSIPKSLEEAARIDGCTFGQAFRKVILPITLPGIAAVGVYAFLFSWSELMYSMSILTSKAKQTIPTFLQLFVGQYQTRWGPLFAGSILATIPPLIIFMILQKFFIAGLVSGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y5</accession>
    <name>I2F1Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">Theba_0203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730101.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0203"/>
    <dbReference type="EnsemblBacteria" id="AFK05938">
        <property type="protein sequence ID" value="AFK05938"/>
        <property type="gene ID" value="Theba_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0203"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_0"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="140"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK05938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="427" mass="46821" checksum="FBEAC2E235A4626B" modified="2012-07-11" version="1">MYAQIVDLVAREVLDSRGTPTVEAEVWLDDGGHGRAIVPSGASTGKFEALELRDGDKKRFLGKGTLKAVENINEVIAPEIIGMNAFDQITLDAALLELDGTENKDKLGANAILAVSMAVARAAADSIDTPLYKYLGGVNAKALPVPFMNIVNGGKHADNNLDIQEFMIVPAGFKHFRDALRAGVEVFHNLKKLLKDSGHVTAVGDEGGFAPSFENNEASLKYIINAIDAAGYKAGEEIMIALDCAANEFYNEDKGLYNIDGNELTPDQLIEYYSNLTKRYPIISIEDPFAEEDWESFAKFTREIGDTIQIVGDDLFVTNIKRLKKGIEKKSANSILIKLNQIGSVTETLNTIEYAQKHGMTCVISHRSGETEDTFISHLAVAANTGMIKTGSASRTDRIAKYNELLRIEEELGEQAEFRGRESFYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z5</accession>
    <name>I2F1Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730110.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0214"/>
    <dbReference type="EnsemblBacteria" id="AFK05948">
        <property type="protein sequence ID" value="AFK05948"/>
        <property type="gene ID" value="Theba_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0214"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="32425" checksum="16DFAEF2D53668BE" modified="2012-07-11" version="1" precursor="true">MPAKRKSEFRKIMKKYWTNGTAVLGTCLLIFFIIIAIFAPQIAGVNEMGDNYQIPRASWSSKPIAPSAEHPFGVIGGRDVFYGVIWGTRTAFRLGLIITSMAALIGVIVGSISAYFGGWVDEILMRITDIFLSIPFLVAAMVMTTVLGKGLDKVIIALIIFGWMSTARLIRGNILQAREEQYVLAAKALGQKDWKIIIKHILPNTIFPVVVQMSMRIGSYVITAAGLSFLGVGAEPGYADWGTILSYSRNWMTMLDQSWFAIVFPGTAMVLFVLAWNLVGDALRDIFDPRMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F246</accession>
    <name>I2F246_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730157.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0266"/>
    <dbReference type="EnsemblBacteria" id="AFK05999">
        <property type="protein sequence ID" value="AFK05999"/>
        <property type="gene ID" value="Theba_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0266"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_1_2_0"/>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="177" mass="19796" checksum="842D1654BCF15E05" modified="2012-07-11" version="1">MLQVRLRGLALDQSNSPVVILEVEKTNKGFGIWIGPFEAEALALAISGKDFPRPLTYDLFVNTVTQLGGVFEKAVIGQVKDNVYYASLHLQDRTGQLYVVDARPSDCLVLAVKKGFPIFVEDSVFKESSIDLSNLQTDALQHGQEEDTEGFKKFVENLDIEELKKHFRSKEDDSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F275</accession>
    <name>I2F275_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491768.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0297"/>
    <dbReference type="EnsemblBacteria" id="AFK06028">
        <property type="protein sequence ID" value="AFK06028"/>
        <property type="gene ID" value="Theba_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0297"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="274" mass="30625" checksum="078677160EE13C13" modified="2012-07-11" version="1">MRLYTEMKETVVRRLTTFPKVAMILGSGLGYLTEQFEEPLAIDYREIPGFPTATVEGHSGRLVFGTFQGLPVVAMEGRFHFYEGHRIEDVSSPIYLFKELGVSNLLITNASGGINRSFSPGDIVAVTDIINFGFRNPLRGENDRRYGPRFPDMSEIIDFAWLKVLKSRLEKAKIDLKEGTYCWTLGPSYETPAEIRAFEFFGADLVGMSTVPEVIAARHCGIKLLVLSCVTNMASGILKEKLTHADVVKTANRIRPKFTAVVQHAVESIKETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B1</accession>
    <name>I2F2B1_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Lipid A core-O-antigen ligase-like enyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFK06064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK06064">
        <property type="protein sequence ID" value="AFK06064"/>
        <property type="gene ID" value="Theba_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0335"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011262_0_0_0"/>
    <dbReference type="OrthoDB" id="825157at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="415"/>
        </location>
    </feature>
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        <location>
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            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK06064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="916" mass="103840" checksum="E05E71824CC25F7E" modified="2012-07-11" version="1" precursor="true">MCKGRYFFYTIFVLGSSLFAIKGFTWDMGLPKFYFASVAISVFIVFVSLRAVRGSYKLSISFPQVLALLFGIYACLTTFQLLDTLPNVFLTSLGFAMNLLLFLLFSLLISGEKPDRLMFILQVFVLAGLVIAVDALFSFYTGHGLLWGTENNPFTRGNLSSVIGNVNFTTDLMAMLLFPTAFLTISSRVLWKREKLRHIFYLGVFSIFLIVILIGQTRAVYYSVIGSFTFLAVFLIISLLKFRLRPFATVFNKLFLILLIFAAIIIMIVYSGDNFLTGGRFSFSERLTYTTEDNVSVDVRVLQWKAAIKQWKGSTIFGTGFGSYKYLSTENMGRVLLEEPDYMYVAGLNSIRTHNEYLQQLGETGMVGMAIVAWFILSMFLYTIRVVRRTPSIDKIVQYIFLTAGLLVIFAHSILSFPGHLMPNALFAVFLFGFLMSPDFNEEKRITFNVGKLVPLILVIFALTTTVLMSRTFFSEGFFTKGYIDYRRIEAINPQVPQLISSIESIKKEIEALENVEDKYANLQEGQYISERLKTLQEMYPSAPTELLESIASEDREEAYESTLSGLNSKLRSASSALLNARRDSTDSFYSALRNLSTAREISGSQYLAEAYLGYVYLTPQRKEDFRLKLNMSGNNIGNAFGEIFSRKDIFSSWLTNDVLPCGMLPGLEIDHAYLKELQSLLKPDLAATDVSDLLKEVNTELLIDYQVTLDAIDALLRSIKTSPDLQVVRNAASLLFRVIVSSERISVELEKLEPYVTDTVGLNNLVHKIQEIPVSEKDNLNLLYDVAIAYNPGGWLKGNDSIYGEYARNLLLAYGLNALDKILELAEKEVFAWNVMRTTDQVVPLGAIGELTPLKEYVPREWFNNLYDGVYEWCLDKSSEISRNIEEERFAGENLKKAETVLNEMERFKELYSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B2</accession>
    <name>I2F2B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0336"/>
    <dbReference type="EnsemblBacteria" id="AFK06065">
        <property type="protein sequence ID" value="AFK06065"/>
        <property type="gene ID" value="Theba_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0336"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_1_0"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="129" mass="14601" checksum="D24E7BAEA065BE76" modified="2012-07-11" version="1">MRYSVKTERKSQFIDITKLVIQSVKESTASYGLVNVFVPHTTAAVTINENSDPDVVRDILFWMDESIPENREFKHMEGNSDAHIKASLVGSSVTVPFRDNSLMLGIWQCVYFCEFDGPRNREVIVTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D6</accession>
    <name>I2F2D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491940.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0360"/>
    <dbReference type="EnsemblBacteria" id="AFK06089">
        <property type="protein sequence ID" value="AFK06089"/>
        <property type="gene ID" value="Theba_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0360"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_1_0"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="351" mass="36306" checksum="C9D271C23D882011" modified="2012-07-11" version="1" precursor="true">MNTGKIYALLVPIVSVLIALLIASIIIIMIGKNPVTAYAIMLDGAFGSQEAIADTIMKMTPLILTGLAVGFGFRAGVFNIGAEGQMTMGALIGAVVAMNIGGIPSVIAIPLSILAGMLAGAFWASIAGFLKAFTGAHEVISTIMLNWIASNLASYMVTGPLAVGSGTPKSPEIAEASKLPVILKVQATELSIGIFIAVAVAIIMYILIEKTTTGYKLKAVGFNPHAAEYGGISIRKSIILTMAISGALAGMAGIVDLIGVPPHRFVGELTGGRGFDGITIALIGRNNPIGIIFAALLIAALRTGSNAMQIRAQIPNDIVSIIQGIVIFLVAAERIVSTLISWKRKKGVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J8</accession>
    <name>I2F2J8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">Theba_0423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730266.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0423"/>
    <dbReference type="EnsemblBacteria" id="AFK06151">
        <property type="protein sequence ID" value="AFK06151"/>
        <property type="gene ID" value="Theba_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0423"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_1_1_0"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="102"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="34015" checksum="68D83616C7DE1EA7" modified="2012-07-11" version="1">MSRRIAVVYGGFSSERDVSVKSGSNISKSLERLGAEVIGFDLKRDRIASLLSLKADLFFLALHGKFGEDGTVQGLMELAGLPYTSSDSRTSAVCFDKEITYRLVKAEVDLPLWKKVISEKDLEGWKIFPCVIKPTREGSSIGVFICDDASTLINRTRLLLDVYDSLLLEEYIDGREITVSIIDSREGIKVLPVLEIKPKRRFYDYEAKYTPGLTEFVVPAPIERSTLESIIEKSVAVYKLLGCRDFARVDGILKGGVFYFLEVNTIPGMTDLSDLPMSARAAGMTFDDVVLDIIEAADKRNRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U4</accession>
    <name>I2F2U4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trmFO</name>
        <name evidence="12" type="ORF">Theba_0524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730354.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0524"/>
    <dbReference type="EnsemblBacteria" id="AFK06247">
        <property type="protein sequence ID" value="AFK06247"/>
        <property type="gene ID" value="Theba_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0524"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_0"/>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="3"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="431" mass="47904" checksum="456F06AD706E323C" modified="2012-07-11" version="1">MIINIIGGGLAGSEAALSLADFGQEVNLFEMRPNVKTDVHQSGDFAELVCSNSFKSESLDNASGLLKEEGLRLGSRLLEIAYHNRVPAGKALAVDRKAFSEEVSMKLETHPLINVRREEVCSLDFDGAVNVVCTGPLTSGCFEAFLGELFGGALFFFDAVAPIVAADSVDLERAFIADRYSDNGDYVNCSLSREEYELFWNELVHAEVLEVENFSDRFLFERCQPFEEIARSGIDALRFGPMKPVGLIDPITGKEPYAVVQLRKENLSGSLLGIVGFQTRLKWREQKRILSLIPALRNVDIIRYGVMHRNTFLDSPRLLNPDLQSRNHKGLFFAGQISGLEGYVEAIVSGRLAAINADRYVRGKQTVIPPVGTMIGGLINHITVSGRSPLKPVYANFGLLPEIRMKNRREKNRKKVVVAQEKIQRFLEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V6</accession>
    <name>I2F2V6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="16" type="ORF">Theba_0536</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492163.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0536"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="AFK06259">
        <property type="protein sequence ID" value="AFK06259"/>
        <property type="gene ID" value="Theba_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0536"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_45_1_0"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="85"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK06259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="23647" checksum="BC1CA29D34EBA5B7" modified="2012-07-11" version="1">MTLTEKQKKILEYIENFIKLYGYPPSIRDICRDFEISSPRGVAKHLESLEKKGYIERTGVSRGIRVLRSPDGSSLEPGEDVVMLPVIGNVAAGEAIQAVQTEDEKIPVPLWMIRRGFEYYMLKVTGNSMIESHIVNGDFVIIRKQEWANNGEIVVALIDDEYATLKKYENEGPKIRLVPSNPEMLPIVVEANRVKIQGRLSGVLRWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F301</accession>
    <name>I2F301_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prepilin signal peptidase PulO-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730393.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0585"/>
    <dbReference type="MEROPS" id="A24.019"/>
    <dbReference type="EnsemblBacteria" id="AFK06304">
        <property type="protein sequence ID" value="AFK06304"/>
        <property type="gene ID" value="Theba_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0585"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_0_1_0"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="9">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="8">
        <location>
            <begin position="109"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="256" mass="28270" checksum="61D1D3E579DACABD" modified="2012-07-11" version="1" precursor="true">MWDYIVLRVSLFFIFGLIFGSFSNALIFRIPSKEYSMTRPRRSICPKCKHQLSWKDNIPLISYIFLGGKCRYCGEPIAARYPVVELLTALLFSLNSVVFSLFGAISMSVLTMGLIVSSFIDLEHYMIPDFGVILVAAGGFAWSTVEGRFPANLLHALLVTGAMVAFFFIANLVRKDSFGFGDVELLAALSLASGIIGSLYTIMVASFAALIVYAINAAAKGRKFDRRAQLPFGPFIAVGGYTTILFLDFIEALYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F311</accession>
    <name>I2F311_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein of DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0595"/>
    <dbReference type="EnsemblBacteria" id="AFK06314">
        <property type="protein sequence ID" value="AFK06314"/>
        <property type="gene ID" value="Theba_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0595"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_5_0"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="180" mass="19852" checksum="BCCC8A01B421BB0E" modified="2012-07-11" version="1">MPVVVIGTMNEERPNYTTIALCGVVEVQPPMIQISLAKSRLSCKNIEDTGYFSVNVPSLDMLRGVDYMGIHSGKTTDKSELFRTFLGEKGNVPMIEEAPLNMECELVSKFEFGGAHIAFVGEVVQTYCSESCLVDGLPNIKKISPVTFSVYDNSYWSIGMHLGKAWNIGIKYTPPKEGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F323</accession>
    <name>I2F323_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730404.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0607"/>
    <dbReference type="EnsemblBacteria" id="AFK06326">
        <property type="protein sequence ID" value="AFK06326"/>
        <property type="gene ID" value="Theba_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0607"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426470_0_0_0"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="192" mass="21961" checksum="F40B5247971EBD5C" modified="2012-07-11" version="1">MPLKLPDLFRTLSNQTRLEILTMLMDNYLTATEIATLLQIDLSTVYRHLQQMKKLGILTSTHLHGVERFDFSSPHIFRMLDEAITFMSELKGFSPIVCSEGICSYYLGGELDEIEPDQLLDMRGESCPVPDIQARKTLRKMNPGEILLVIVDYPLSGERIPASVQKEGHEFLKKVADNYGDIKIYIRRRENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F331</accession>
    <name>I2F331_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730412.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0616"/>
    <dbReference type="EnsemblBacteria" id="AFK06334">
        <property type="protein sequence ID" value="AFK06334"/>
        <property type="gene ID" value="Theba_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0616"/>
    <dbReference type="eggNOG" id="COG5421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022426_5_1_0"/>
    <dbReference type="OrthoDB" id="995276at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="523" mass="61150" checksum="8B381647BD667B41" modified="2012-07-11" version="1">MFLRLKHFKNKDGSTRSYLQLVENIRVGNKTRQKVLVNLGRVDDLQNSGQIDRLIESLRNFSTKEWIRKEALNVNQTYLWGPVIIFEQLWKELGIERVLKRLLGDTDVVSDYVEAIFAMVLNRLVEPRSKRGVDRWVSKVYRPEFEQLSLQHYYRGLDYLEKFKEEVEEELFSNVKTLFNLNLDLVFWDTTSTYFQGEGPELSMYGRSKDHRSDCKQVMIGVLMTKDGFPVAHQIFPGNTADIDTFRIALEDIRRRFNIDRVIVVADRGMISNGLIEEIDKAGLSYIFGVKMRRSKRVEAVLNQPGDYEEVEENLKVKEVLHEGERYVICFNPFQAERDRIKSEEIVKNLSKKLKEGPKSLVGNRGYRRYLNIQKTDVKIDQEKMASEVKYNGKYVLRTNTKLTNREVAQSYKLLWKVERTFRELKSGLDLRPIYHYTDTRVKGHIMICFLALVMETALCRKLKEIGSTFSYAEILEDLTEIRAVEITVEGKRFLARTETMGNAYDAFKALKIRPPNLLKEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F361</accession>
    <name>I2F361_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730440.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0647"/>
    <dbReference type="EnsemblBacteria" id="AFK06364">
        <property type="protein sequence ID" value="AFK06364"/>
        <property type="gene ID" value="Theba_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0647"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_0"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="35012" checksum="67E83BFAE97EB26B" modified="2012-07-11" version="1">MLQEIIVSSREDGWRLDKVVVEKAPPWVSRTFVQRQIKNSKVFVNSRPRKPSYKVKIGESITFDLPEKPKVASVEPEAIPLKIVFEDRDIIVVNKDPGIIVHPLPRKQTGTLVNALLYHCKDLQGIGGVTRPGIVHRLDKDTSGIIIVAKNDLAHVSLSSQFKSRLTAKEYIALVRGKTPPFGKIDYSIARHPVNRLKMSVNENGKESLTYFQTLSNFSSIASLIIVRPRTGRTHQIRVHMKEKGFPLLGDAVYGKAREDEIFGIKRQMLHAMKLTVSHPRSGIRMTFIARLPEDMKEAIVNLSELEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F369</accession>
    <name>I2F369_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg/Co/Ni transporter MgtE with CBS domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730447.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0655"/>
    <dbReference type="EnsemblBacteria" id="AFK06372">
        <property type="protein sequence ID" value="AFK06372"/>
        <property type="gene ID" value="Theba_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0655"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114937_0_0_0"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="128"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="204" mass="22735" checksum="2425F2D7FAB76A6F" modified="2012-07-11" version="1">MNIEKWINRTYPVFEESSTLEDVFSIKALAGLTNIISVDKEGRLSGTARLDEIDDFDLSKKLSEIVVEPVFYCRDSDFIEDAALMLIESHDYVLPVVNDDFVVVGAIGVFEILEGLMEFTAMDRPGARISIILEDKPGALREVVDFLAEKEVNILSIITSTAESKEFKRVVIRTDESDISLIADILGEKGISFESISEEEGFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B8</accession>
    <name>I2F3B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">Theba_0704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730479.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0704"/>
    <dbReference type="EnsemblBacteria" id="AFK06421">
        <property type="protein sequence ID" value="AFK06421"/>
        <property type="gene ID" value="Theba_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0704"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_0"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="24104" checksum="37488B661B4C3F6F" modified="2012-07-11" version="1">MARYTGPVCKLCRREGFKLYLKGERCFSPRCSQVKRPVAPGQHGASTRKLTQYGMQLRSKQVVKRIYGVLERQFRRYFEAALKKNEETGTALMKILESRLDNIVFRMGFASSRRQARQLVNHGHVLVNGRRVNKPSFNLRVGDIVEIKEKSRSVLPIKEAAEAAKERTAYPWVEVDYETFRGTYLRYPVTEEVEIPVDLQSIIELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F5</accession>
    <name>I2F3F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730512.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0743"/>
    <dbReference type="EnsemblBacteria" id="AFK06458">
        <property type="protein sequence ID" value="AFK06458"/>
        <property type="gene ID" value="Theba_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0743"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_3_0"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="344" mass="36798" checksum="CA7122CE332F4D9D" modified="2012-07-11" version="1" precursor="true">MISRLHNLGRSLLVIAISLSAGLLLVMLMSDDPGHAARAFFLSVFSNRFYFGNLLAHSIPLMLTGLAASVAFTASCFNLGMEGQVYLGALAGTSAGILISDLMPGAIGIAFMFTVSFFFGASVASISAILKIRTGVSELISSLLLSNGIVLVVDYFVEGPLNDRASGLAASISLPAKFRFNGLMLPSGLHTGIFFSLCAAFLLWFFLFKTREGFKIRIVGKNRAFAFYAGLKTNRLLFWALFLSGGLASTAGIIDVVGIHGRVMRGFSSGYGWNGIAIALIARNNPLMVIPAALFFAYLESGAQIAALEANITPEFARIVQAVIFFLITAEALVPKHLGRKRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K7</accession>
    <name>I2F3K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730562.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0796"/>
    <dbReference type="EnsemblBacteria" id="AFK06510">
        <property type="protein sequence ID" value="AFK06510"/>
        <property type="gene ID" value="Theba_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0796"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116722_4_1_0"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="120" mass="13132" checksum="652DF3CB424E02F3" modified="2012-07-11" version="1">MSERILVGKALDVEPQFFDNKNVKSVTKRVLIGKKKGATNFVMRLFTVGEGGYSPHHSHPWEHEVFIISGEAAVVTDQGVINAGKGSYVFVPSGVKHQFRNTGNGDLEFLCVIPSSADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R4</accession>
    <name>I2F3R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730606.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0856"/>
    <dbReference type="EnsemblBacteria" id="AFK06567">
        <property type="protein sequence ID" value="AFK06567"/>
        <property type="gene ID" value="Theba_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0856"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="7">
        <location>
            <begin position="277"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="471" mass="53286" checksum="4D34ED57AB5392AE" modified="2012-07-11" version="1">MDKTVDGNFSDCSSIKILLVEDLKSDAELAELEITKGLSGWCDSVGFLRVDNREDFLQSISNYKPDIIISDYMMPHFSGMEVIDLALKFSPSTPIVILTGSMNEETAVECMKAGASDYVIKEHMARLPFAVKEAIKRKKEERLRAAAEEALEESERKFRLIAEKANDLVYRYELFPEKKFSYVSPSATKITGYTPEEHYSNPNLGFELVHPDDRWKLDGLSEQVNQSPILLRWIKKNGEIIWTEQMNVPVYDDEGNLIAIEGIARDVTERQKTSEALKAAFNSVVTVLSDVLNLKDPYTEFHEKNVAKLAVEIGRKMDLDESTIEALRVSAMVHDIGKIMIPTEILSKPGKLSDIEFEIIKRHPVTGYEILKKVKLPWPVAEIVYQHHERLDGSGYPRHLKEKEILLEAKIIMVADVVEAMSSHRPYRAALGFDAALEEIRSNAGRLYDPKIVEICASIIEGGFTFLESDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V9</accession>
    <name>I2F3V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal phosphate-dependent acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730642.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0902"/>
    <dbReference type="EnsemblBacteria" id="AFK06612">
        <property type="protein sequence ID" value="AFK06612"/>
        <property type="gene ID" value="Theba_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0902"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_0"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010962">
        <property type="entry name" value="AONS_Archaea/Firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01825">
        <property type="entry name" value="gly_Cac_T_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="39"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="394" mass="43141" checksum="CBD0324943F68A48" modified="2012-07-11" version="1">MFDFDVLKKEMEELEEKGLLVKIRTLESPQGAWLNIEGKKVLNMCSNNYLGLCFDEELKEAAIDGIRKWGVGPGAVRSIAGTLELHNELETELARFKKVESTLVVQSGFNANQSVIPPIVSEEDAILSDELNHASIIDGVRLTKAMRYVWKHKDVDDLEAQLQKAETDGARRKLVITDGVFSMDGDLAPLPQIVEKTNKYGAILMVDDAHGEGVLGSHGRGIVDHYGLHGSVDIEVGTLSKAFGIVGGFVAGKRVLIDYLKQKARPFLFSSSLSPAETAAAIAAVRKLSSSDELVKTLWSNSDYFKEQLKALGFDTGHSETPITPVMLYDAKLSAAFSKRLFEEGIFASSIGFPTVPKGKARIRVMISASHSRKDLDFAVSKFELIGKELGVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W3</accession>
    <name>I2F3W3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492613.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0907"/>
    <dbReference type="EnsemblBacteria" id="AFK06616">
        <property type="protein sequence ID" value="AFK06616"/>
        <property type="gene ID" value="Theba_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0907"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_0"/>
    <dbReference type="OrthoDB" id="715502at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="494" mass="54133" checksum="90F0AD11430D7467" modified="2012-07-11" version="1">MLIDGQHLTLSDIFEVAFKKEFCSIEESAARLLDERRRSLELISKEKTIYGVNTGFGVLADHRISSKDLDALQKNIVLSHAAGVGEPLRQELVRAIMLVRANSLLKGFSGVRKCLVQRILDLLNEDIVPVVPSKGSVGASGDLAPLAHVAMSLIGEGYCTLEGSVVPSLQALKSRNLEPIILKSKEGLSLLNGTAFMAGIGGCSTYIASRLFEQAILVSAMSVDALMGSTSPFDERVHSARPHRGQGYVAGRMKSLLEGSEIRTSHLDCDRVQDAYTLRTIPQVYGAVKDTLDYVKSVLEIEINSATDNPLIFENGDVISGGNFHGEPIALAMDFLSIALTDMGNMIERRVDRLVNPKLNDLPAFLTNGDEGLNSGYMLWQYTAAALASENKTLAHPASADSIPTSGFQEDHVSMGAWGARKLWMIVDNLATMISIEALLAFRALSFRHPKKSSIAVEELFEDIRRIVPDHINDRYFGNEFMEVRKLLFRRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z5</accession>
    <name>I2F3Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730669.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0942"/>
    <dbReference type="EnsemblBacteria" id="AFK06648">
        <property type="protein sequence ID" value="AFK06648"/>
        <property type="gene ID" value="Theba_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0942"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="307" mass="34428" checksum="D10B54023454A1CE" modified="2012-07-11" version="1">MKTLEVRDLSSRIGNFDLGPIDLSVEKGEIVGLIGPSGCGKTLLLRTIAGLQEPLSGSVTINEDDVTFLEPHLRGLAFVFQDNALFPHMDTHDNIAFPLSVMKDREADAKVSKRAGELDGLSDYLDRWPKELPAGMKKLTAFARETVKKFNLIMLDEPFERLDKKIRIEMRSIIKRMLMALGESVLIVLNDPEDAMAIADRVFIMDSGVVLRQGSPTEIYDEPNSLFVMELFSAMGINRVGGRAFRPQDVELDDQGEEFNPEHCGPYDSKRIICNGKLGGEDVTLMLPIECRDMDSIFIRITRFFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F410</accession>
    <name>I2F410_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730684.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0957"/>
    <dbReference type="EnsemblBacteria" id="AFK06663">
        <property type="protein sequence ID" value="AFK06663"/>
        <property type="gene ID" value="Theba_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0957"/>
    <dbReference type="eggNOG" id="ENOG50346FG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473369_0_0_0"/>
    <dbReference type="OrthoDB" id="2024431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="183" mass="21234" checksum="F78E30F1A11C9B08" modified="2012-07-11" version="1" precursor="true">MLISETLHVLFSVIIITLLATVLSVASVFAFQRQIRKPTFFLLFMNVAFASGVIFLANIVFARNDRLLNVAIFFIAYLYVYGSLGKHTSRYDDTFRMLFLSMGYTRQEFFKNYLLLQGKWKLVDCVFTFSAIATAIKLMSVHFKYFYPGEWLQIMLLFMVICMVVGISRWFGDNSVNKLSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F460</accession>
    <name>I2F460_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730724.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1008"/>
    <dbReference type="EnsemblBacteria" id="AFK06713">
        <property type="protein sequence ID" value="AFK06713"/>
        <property type="gene ID" value="Theba_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1008"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_10_0"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="304"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="652" mass="74357" checksum="10C56FB9937D75F9" modified="2012-07-11" version="1">MKKYTLKSSEIPGFLTEGLDEEQLKAVIESSGRSLIVAGPGSGKTRVITYKIAHLVSNSINPQNILLVTFTRAASREMIDRARRVSGSNLKGMLSGTFHHVCNYFLRKYAKAAGLAENFTILDREDAKDLIKHCRTELLEERKGINSSTLPSAGVLQSIYSYSVNVLSSLRESTARKNRKFLGSYDEIEEIWKRYVQEKTVQNCVDYDDLLLKALKLFNDNPSILNKEAERFRWVLVDEFQDTNVLQFRLVEMLSSVHGNLIVVGDDAQSIYSFRGARFENVYDFLSAKDARIYKIQTNYRSTPQIVELINSIVPQDSIEKQLRAVRMNGPIPVVAETWDNLEEASFVAQRIQEHIDDGVDPENIAVLYRSHYHSLELQMEMDKRKMNFTLYSGPRFTETAHVKDILALLKVIENPLDQVSWGRILRLFPGVGNATSLRIIQGISAAANDGHRAEEVVNSHVSKRIKLDKLVSILGATNEEEPPTEIVRRFYADFYGDYLDEKFPDARERRMDVERLIEIAGRYISISDLLEDLAVSEKIDIERESAEKQPSVVLSTVHQAKGLEWEVVFILAANPGDFPNSMAILEGSLSEEERIFYVAVTRAKDYLYILRQKGGRSRPMIGNRYVFRSGHDFVEKLPKNCFERWDVSWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F494</accession>
    <name>I2F494_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730753.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1042"/>
    <dbReference type="EnsemblBacteria" id="AFK06747">
        <property type="protein sequence ID" value="AFK06747"/>
        <property type="gene ID" value="Theba_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1042"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_2_1_0"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="367"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="453"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="571" mass="63776" checksum="BD545A73331630BF" modified="2012-07-11" version="1">MEEKMNRQDENLSMEEIFEQMDVSSARKGSRKDAEVFSIQPDGLMVIMDGKLDGFVPADQLVNELEEYNVGDKIEVMVIKTNEEEGRSTVSEKRVHARQAVSKVEKAYREGKAIDGKIVSETKAGYNVRLVKTVPAFLPGSESGIRKGDPAPEGTLKFKVIRFKRQRNGINVVVSLRAFQEEAIKAYFETIEVGQELEGTVESIKNFGAFVKLNDNVTALIPASEMSWDPSVRISDLLKPGQTVRTKVIGVDEAEKKISLSLKQMTEDPWSTLKDRYEVDSTVVGTVKNITPFGFFVSLEPGVEGLVHISEVFWGNIKKDLKSVVEVGDEVKVTIKEINEEKRTLSLSYREAMGDPWQNIGDKYKEGDILKAKTAKVLPTGVILELEEYVSGFVPVSEVSWNFVDRIEDVVKEGDEIEVKILSIDSVNRRMRLSIKQAYSDPWEKVSAELSVGDHVTGTVTRLTKSGAIVLIDSYGVEAFLPVSQVSLERTENIEDSVQVGRHDQFKIIRLVYDPDNDTRNMVVSIRQLIKDKEAAETDKALKDLNGNGSVNSNSLGEMIKNQLEEEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B2</accession>
    <name>I2F4B2_9BACT</name>
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        <submittedName>
            <fullName evidence="2">GTP-binding protein YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730765.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1060"/>
    <dbReference type="EnsemblBacteria" id="AFK06765">
        <property type="protein sequence ID" value="AFK06765"/>
        <property type="gene ID" value="Theba_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1060"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_0"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="274"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="359" mass="40524" checksum="86378A34A1654A27" modified="2012-07-11" version="1">MEIGIFGLPLSGKSTLFTLLTGVEPHSSHKNEAHTAVAKVHDRRVDELSKIFNPKKTVYATVSFTDIPGYDLAANQKEKNRILQFIQNSEAVMAVVRAFKDTSVPWPTGAYTPVKQLETIETELLVRDMEVVEGRLLRLEEAKKKRKLSADEERETELLHLIEKGFDENSFASQLELAEDDLKLLGSLALFTAKPIIVAINLDEDQFSANDYPERETLLQRISERNFAHIELSGKIESELMELSEEDREIFMEELGIFESGIERLSRVVYEHMGLISFLTVGEDEVRAWTIKKNTPAKAAAGKIHTDLERSFIRAEVIPYDEFMTVGSMQEAKAKGMVKIVGKEEIVKDGDIFHVRANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D5</accession>
    <name>I2F4D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730786.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1083"/>
    <dbReference type="EnsemblBacteria" id="AFK06788">
        <property type="protein sequence ID" value="AFK06788"/>
        <property type="gene ID" value="Theba_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1083"/>
    <dbReference type="eggNOG" id="ENOG502Z800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077081_0_0_0"/>
    <dbReference type="OrthoDB" id="1059630at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009561">
        <property type="entry name" value="DUF1177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06675">
        <property type="entry name" value="DUF1177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="309" mass="33316" checksum="A87F5C4BA3DE0942" modified="2012-07-11" version="1">MLRQVMDVLEILDSPYANGKEVAELFIPYEGVIVEIEKVGSEKGSTDIVRILIEGEDPSLPVLGVIGQLGGIGARPEMIGFVSDGDGAAAALALALKAAQASDKGDRLPGNLYVATHICPDAPTQRHEPVPFMGSPIGTRQALQAMLKRRLDAVISIDTTKGNRLINWKGIAITPTVKEGYILKVSDDLLDICESVTGQPARVLPITMQDITPYGNRVHHINSIMQPCTLLSVPVVGLAITTELAVPGCATGSSHELDIELAARFSLEVAKRFGQNKCKLFDHTEFERISGLYGDMSRLVFSTEDLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E6</accession>
    <name>I2F4E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730797.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1094"/>
    <dbReference type="EnsemblBacteria" id="AFK06799">
        <property type="protein sequence ID" value="AFK06799"/>
        <property type="gene ID" value="Theba_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1094"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034454_3_0_0"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658517" evidence="3">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="448" mass="50089" checksum="7D70B7FA322B5414" modified="2012-07-11" version="1" precursor="true">MRKIVAIMLLFAVASTSMPVAVVFSGGGGRGAYEIGVYGALLDLGQDIEGIYGASVGALNAAGLISEGFEAARDLWCSMDYLELMNASPQLYELIQGNIAQLDTLELASAMRALTSNNGIDIEPLRNKMKELIAEEEVRESEIELGIVLYSLSEMKSYALYKASIPEGKLVDFVLASANFPAFTREEIDGEVFIDGGVYSNFPLFMAKERGHRDVVAVDLIGMYFGDSLAYVNMFTDGMDVTLIQPSEQFGTVMTFDSEVSKNYLICGYLDTMKAYEVLRGEKYFIFGDDDPLRDHFLSLDSESRIEALKLLGLDGVKGECAEYHYYRQFIPWLESTLKRPYMGTSKLVSSVLEEMADFLEVERVIAYSPSGLLGAVLAAYRAGDFRDERDLNYLTIYKRLLVFLEYLHWQKPFEAQSSAEFRSFQELFQSSVGLLEHTYSPRGHISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E7</accession>
    <name>I2F4E7_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730798.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1095"/>
    <dbReference type="EnsemblBacteria" id="AFK06800">
        <property type="protein sequence ID" value="AFK06800"/>
        <property type="gene ID" value="Theba_1095"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="204"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="403" mass="46730" checksum="8495CC5481DFC3F4" modified="2012-07-11" version="1">MLKIVRVTSRLDRKEFTDLPESLYRDYPLWVPPFSHEMKALLKSRGSQLLANGPHVFFIAKDDNEVKGRIAVGIEQVMNNEKSVKHAYFTLFESVDDREVAEALLRTAESWARNKGMNYLKGPVSPTNGDDYRGLLVDNFDDPPAVLMPYNPPYYASFFDSFEIYLKYLGFQYDLANVISEREIKFTEIAMDRYKFRVEEANFRRIREVSADLQKIMEESIPNWEEDILPPTYDELYDMAKTLKLVADRRMVIIARSGERPIGFFVALPDFSPIIREIEGRLLPFGWYKFLRLRKSLERARAAILFVVPDYRNKGVPSAMFLRAYRNIQNMGFKEIEGSSISSMNLTMIANARRAGGKEYKHYIVYGKSLLKRPLSLSEIYGPAASRYVPKGQRNSERVLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G8</accession>
    <name>I2F4G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1116"/>
    <dbReference type="EnsemblBacteria" id="AFK06821">
        <property type="protein sequence ID" value="AFK06821"/>
        <property type="gene ID" value="Theba_1116"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1116"/>
    <dbReference type="HOGENOM" id="CLU_1883299_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="135" mass="15864" checksum="326D931C24DAF462" modified="2012-07-11" version="1">MAKRPAFDVKVNGFFVYNGQRLFIRSKVCQASNDKIDKVKYMALKLRSTCFWDVDIKKMDKEKDKFFIISRILEYGTMEDVVSLLSEYDSEEIAEVVKRSRIIGRATANFWGLILSIPRSEITRCLEPEDFHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N3</accession>
    <name>I2F4N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family (UPF0150)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730874.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1188"/>
    <dbReference type="EnsemblBacteria" id="AFK06886">
        <property type="protein sequence ID" value="AFK06886"/>
        <property type="gene ID" value="Theba_1188"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1188"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184590_0_0_0"/>
    <dbReference type="OrthoDB" id="2012308at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="69" mass="8028" checksum="3CB907E18F4502FD" modified="2012-07-11" version="1">MDTEIIFLVEEDSVSGFFARALGHPIFTQAETLEELKKNIRDAIRCHFDESELPRIIRLHFVKEEVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R4</accession>
    <name>I2F4R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional Coactivator p15 (PC4)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486560.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06917">
        <property type="protein sequence ID" value="AFK06917"/>
        <property type="gene ID" value="Theba_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1223"/>
    <dbReference type="eggNOG" id="ENOG5033BJS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104273_4_2_0"/>
    <dbReference type="OrthoDB" id="1920499at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="SSF54447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PC4" evidence="1">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="70" mass="8271" checksum="A14C8A1B89CB7004" modified="2012-07-11" version="1">MTDIKRNDTEIVRVSKREYKGHEFIDLRIYYQDDEGDYKPTKKGITINPKLVDELIDALKKEKDSAPEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F516</accession>
    <name>I2F516_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L11 methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486736.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1331"/>
    <dbReference type="EnsemblBacteria" id="AFK07019">
        <property type="protein sequence ID" value="AFK07019"/>
        <property type="gene ID" value="Theba_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1331"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_2_0"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="270" mass="30257" checksum="7C852BF5F175AE5F" modified="2012-07-11" version="1">MRYRHLIAFVTPEESDSIEGMSWNEGFTNLYFEEIEGSGISLHVLLEEGEEVPAFLREIEFSDLGFSEERDWFQKWKETLVPFNLCDGFEVIPLEEEKMVGSGKIGIIPGMAFGTGLHESTRLAAAILNETVREGLKVLDVGCGTGILSVIAARKGAAAVVALDIDEHSIEKTIETARINEVSIEARLSDFLSAVKPGERFDLIVSNMIAELLMKFVLDLPKFLTEDGMVILSGIYKDKYREIESLAEEEFSIENVREDGDWKAITLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F528</accession>
    <name>I2F528_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="9">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnfC</name>
        <name evidence="11" type="ORF">Theba_1343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486760.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1343"/>
    <dbReference type="EnsemblBacteria" id="AFK07031">
        <property type="protein sequence ID" value="AFK07031"/>
        <property type="gene ID" value="Theba_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1343"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010808_6_0_0"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="439" mass="48079" checksum="575517AE81FFB231" modified="2012-07-11" version="1" precursor="true">MRLPTFRGGVHPPEKKELSKDSRLSVLPLPERVYVFLANHAGVPAKPLVNVGDSVKTGQLIAEASGFISANLHSPLTGEVKEIAKYYHPTLSKPDDAIVIEKSGEEEWELLEPAKPYEQFEPEEIIQRIKDAGIVGLGGAMFPTNVKLSPPKEKKIDLLILNGAECEPYLTIDYRYMLERSEGIVRGILAIMRALKVDNAVIGIEDNKQKAIEQMEVAVRSTPIQVKRLKTKYPQGAEKQLIYALTKRKVPSGGLPLDVGVVVDNIGTAFAVYEAVELGHPLVERGVTLTGEGIKKPLNVISRIGVMASELIEYAGGAQEIVERIVFGGPMMGITVPKIDVPTVKGTSGITLLMKSDPLEEFPCIRCGKCATVCPMNLQPFLLNLYGTNRLYDKQVENGLLDCIECGSCSYVCPANIELVKNFKLNKKVYRSLKGGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F577</accession>
    <name>I2F577_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731025.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07080">
        <property type="protein sequence ID" value="AFK07080"/>
        <property type="gene ID" value="Theba_1392"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1392"/>
    <dbReference type="HOGENOM" id="CLU_660240_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="46753" checksum="B866818A08E2F9F4" modified="2012-07-11" version="1" precursor="true">MKKLLLIALTVIFAVGLFGQLGLRTLTPEPTETADASETGEIVPDSEELNTLSLRTIDPLLVSFREGWTSPDDPSWKVEMIGSTEIMIPQDFSIFQEKTGLNYDVQIFDKEELLFGRLFLYQLESYARSELISAVVGSLYGEGATTESSYEETVELDDGRIAYLVSLKIRPEVDYPFVVVYSPSEEAEITEPGAVTMCVFEPLNYSGSELDKAKEIIAGIVGSLISAEEEPEEKEEVIALPSEKEEHTDIFVRMVESLLSEEDLDIYIDDWIEVEGDYFGFMMPPEFSVAFYLADYFEVADLGFQGTVVGKIFVGESEESASTGDVLNQYVYQYLGSFGDYELVDSYTGYVDRESVVNVYALDFSGKLCWMALYSESHDAEFFGPREYFVLLGLADYEEAVMWAEWYTGILATLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A9</accession>
    <name>I2F5A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NHL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731057.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1426"/>
    <dbReference type="EnsemblBacteria" id="AFK07112">
        <property type="protein sequence ID" value="AFK07112"/>
        <property type="gene ID" value="Theba_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1426"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013730_1_0_0"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="496" mass="55882" checksum="F78439FB15E760E1" modified="2012-07-11" version="1">MYGRAIEFPESSKWINVERPLTLADLKGYVVLLDFWTYCCINCIHVIPDLKWLEKKYEDSPFVVIGVHSAKFENEHDERNIRAAVQRYEIQHPVVIDNDYFLWERYVIRAWPSYVLIGPDGKILSKISGEGKREYLSHEISKALEEGKRKGVLSEKRIPVKLELTKSESNLSFPGKIAFGDGENLFISDTNNDRILLTELSTPFVAKTIDQIGSGLSGLEDGPFENARLNKPQGIVYSNGRLYVADTENHALRIADMNQRCLSTLSGDGFQDNDWNYNGDASKARLNSPWDLQTDGRFLYIAMAGMHQIWRLDLENNTISAFAGSGVENIGDGHLKDANFAQPSGLFLDRNSLYVADSEVSAIRFVDLEAGTVQTVAGSGLFSFGYVDGILKRSLFQHPIGIHGEGRFLYVADTYNHAIRKIDLGIRRVETVIKNLREGTCTLNGDKCSSLGLFEPNDVKFHKGLLYIADTNNHLIRVFDGTELKELVIESQEKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C9</accession>
    <name>I2F5C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731073.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1446"/>
    <dbReference type="EnsemblBacteria" id="AFK07132">
        <property type="protein sequence ID" value="AFK07132"/>
        <property type="gene ID" value="Theba_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1446"/>
    <dbReference type="HOGENOM" id="CLU_1110407_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="28063" checksum="83ACF89E66FD4FA7" modified="2012-07-11" version="1" precursor="true">MIFLALWALSYILGVILTEGSIAEHEGYLYRAVSRSLLWPIIIVIHFQFVRKYEKADFDNVWLLSLYASFTFWIIFSAVGIKSIAMIMAIPISFLSAQFLRLSKPSYGRILKHIKSSYLGSISFSFSLVILICSLSLFFSSEAASVLLLFLLLVPAIILTHFKADLLSGGVFAWFSFAVGFVNLELSSYITVAGFSLGAIFLLLVSFSIFIVKEDPSRKVFATVNPTEPIDEAELRIELDQEETRSKSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F1</accession>
    <name>I2F5F1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">Theba_1470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731088.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1470"/>
    <dbReference type="EnsemblBacteria" id="AFK07154">
        <property type="protein sequence ID" value="AFK07154"/>
        <property type="gene ID" value="Theba_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1470"/>
    <dbReference type="eggNOG" id="COG2313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_0_1_0"/>
    <dbReference type="OrthoDB" id="1294333at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="30217" checksum="11A364A0A895C3F3" modified="2012-07-11" version="1">MNNVVALESTVIAHGLPRGVNFETALNMERAVRKNGGEPKTIGILNGEIIVGLREEQIMRLGTAPNVLKVGTAEIPYATAMKRDAATTVSATMAIAKRDGISVFATGGIGGVHRGKDWDVSQDIIELSRTSMIVVSAGVKSILDVPKTLEFLETFGVTLVGYKTDSFPLFHCSRSPYRVNLTINSPEEALLILKEKERLGIDGAVLVANPIPETDSMDYDDLSRLIETALSTAEARGVSGKALTPFLLSTIAELSNGKTLDANISLLINNAALAGQIAGSLGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F8</accession>
    <name>I2F5F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type maltose transport systems, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731094.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1478"/>
    <dbReference type="EnsemblBacteria" id="AFK07161">
        <property type="protein sequence ID" value="AFK07161"/>
        <property type="gene ID" value="Theba_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1478"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340630_0_0_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="712"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="491"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="923" mass="104482" checksum="AF8614BD66AC36A5" modified="2012-07-11" version="1" precursor="true">MAVERRKYWIRHLILIVVVVVVLFPMVWLVSTSVRRDQAAFSSNLFSSRITFQHYRNLLFPERSVGRLILDLQSATYATGEYRGRSQEDLKKTVERYLVKFEDLMDESEEMVASIENGTSAIEKELKEKESLIIREMNEVRLRDKALFEERLQEIGELSEVKMAYAVGELLETTAPSLEGVYPFYIDLLGERADPIVISLETYRKLYEDVFLYRDETLGAIKELEFENKDEVVRSLESIENYISLSSIDYSEWRRVEWLRVINRYLRDVESTMPQAEQDALNSVRTKLYDSFRAAGDAWEEVEAAAEKVSQDLSLLAEEAFGPEYYEYVSAIEELGVVEADKEAVEKALATSESALAELEDSFEVALPTILSEKSKLSALIPPLQIVISKGVEEYTAVSEARLKSSLDEVDSARKTIGLLQQQLAEMQNVQELSSSLSELLGEMAWFSDNKEALANASGNSEVSKGIDVINIAISNLSRILPVLETSISEYVEVSENTTSLRKELKSLEERSEILGSRIAELKEEADRAEAEYLMALESIRIKSTLALVEEEIASLEDGRAYVSKTTDILDTYFGIRASNRYRTLGWYDDFDRANREARDGTALLNQLISTMRDMKEELSSKVNHYIDLRFLGTTVTLDDFGTMQETYNSLFQQVNARYQRASRLISDLIEKPASYSASYDGELREIDKALFRANQIWVQKESTYFYFVRWLLNSVIVALSVSLISVAVAALAAYPFSRMRFRGRKQGLLGLLLIQMFPTIMFMVALYALLQFIGGLIPFLGLNTLGGLIFAYSGGIAFNIWLIKGYYDTISNSLEEAAMIDGATKFQAFTKVILPLARPILAVVAILTFMSIFNEYLIARILLQDMNKWTYAVGLWQFSGRFETSWGPFTAAALIGAVPMVIFFLVLQDYIVGGLTQGGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H3</accession>
    <name>I2F5H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487050.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1494"/>
    <dbReference type="EnsemblBacteria" id="AFK07176">
        <property type="protein sequence ID" value="AFK07176"/>
        <property type="gene ID" value="Theba_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1494"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_0"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="37"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="554" mass="62296" checksum="26995BF031B6B719" modified="2012-07-11" version="1">MSNRERLEKLKDDWKRERVIPLLKRFPERKKEFKTSFDGPVEILYTPKETEDYEEKIGFPGQYPFTRGVQPTMYRGRLWTMRQYAGFGTAEESNQRYRYLLSQGQTGLSVAFDLPTQIGYDSDDPMSEGEVGRVGVAIDSLEDMETLFEGIPLERVSTSMTINSTAAILLAMYIAVGEKQGVDPSKLTGTIQNDILKEYIARGTYIFPPDSSMRLITDIFEYCSKNLPDFNTISISGYHIREAGANSVQEIAFTLADGIAYVQAAIDAGLDPNVFGKRLSFFFNSHNGFLEEIAKFRAARRLWARIMKERFGVTDEKAMMLRFHTQTGGSTLTAQQPMNNIVRVAFQALAAVLGGTQSLHTNSFDEALGLPTEDSVTIALRTQQIIASETGVADTVDPLGGAYFIEELTDRMEELAMDYIQKIDDLGGMVEAVRNGFVQKEILDSAYKYQVSIENKEQIIVGVNEFVSEDKEVKDILRLDPAIENRQKKKIEMLRTRRDNGKVESLLDDLREAARGSDNLMPFILKAVKAYATLGEIANALRDVFGEYTEAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H8</accession>
    <name>I2F5H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxaloacetate decarboxylase, gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731109.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1499"/>
    <dbReference type="EnsemblBacteria" id="AFK07181">
        <property type="protein sequence ID" value="AFK07181"/>
        <property type="gene ID" value="Theba_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1499"/>
    <dbReference type="eggNOG" id="ENOG502ZD9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2093957_0_0_0"/>
    <dbReference type="OrthoDB" id="2227193at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005899">
        <property type="entry name" value="Na_pump_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04277">
        <property type="entry name" value="OAD_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="12616" checksum="9D652F0279FD9B90" modified="2012-07-11" version="1" precursor="true">MPDYVQITLIGVAIVFLVLAMLYVIFNVLGKLLSGGEGHGVKAVSEKTTSNSVLAPLRSIAGDEEEVIAAIAAAVNAVIGHSDFRIRSVSPVPSARASQWKRREPTVYWKVRRNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I1</accession>
    <name>I2F5I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1502"/>
    <dbReference type="EnsemblBacteria" id="AFK07184">
        <property type="protein sequence ID" value="AFK07184"/>
        <property type="gene ID" value="Theba_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1502"/>
    <dbReference type="HOGENOM" id="CLU_2753184_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="70" mass="8175" checksum="0422C14F7D314DDE" modified="2012-07-11" version="1">MLVYFHEDYFVPIKFSYDGIKIIVNAVTSFWVEAVGTQKVYHFSVMTTLGAYNLEFEEDSKKWYSYTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K1</accession>
    <name>I2F5K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487120.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1528"/>
    <dbReference type="EnsemblBacteria" id="AFK07204">
        <property type="protein sequence ID" value="AFK07204"/>
        <property type="gene ID" value="Theba_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1528"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_3_1_0"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="333" mass="36872" checksum="DEA7DD8234E343BA" modified="2012-07-11" version="1">MKVNLGIVGAGIASRELHLPALRRLTELFKITAVNSRTRRKAEEFAKIAGGDVEVFDSYEEMLNSDVVDAVVLAVPIALNPQMIEAARKANKPVICEKPVAATTKEAIRLLHLPGNTPIYIAENYRHIEVYRKAEILIKEGRLGKPLAFSWLKWVDFGQDNKYVQTKWRQTPQHIGGFISDGGVHDVAALRKILGNVEEVSGFSEKNFDYLGAENSAVFNMTLGSNVIGNYSVVYGAPASLNRFEIVCTEGIVQVDKDEATLEIYSSDREKLFLNKTDGFAEEFTDFHRVLEGQINSLGSVEEAVMDLATIEAGLISAKEKRVVRVDSLLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N1</accession>
    <name>I2F5N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoform II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731143.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1562"/>
    <dbReference type="EnsemblBacteria" id="AFK07234">
        <property type="protein sequence ID" value="AFK07234"/>
        <property type="gene ID" value="Theba_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1562"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709422_0_0_0"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="397" mass="44186" checksum="E3A4083CFE318E74" modified="2012-07-11" version="1" precursor="true">MRETHGSVDIGLIIGLFSLVLIGSLAYLFPTAKIPDPGGKYEVGVEIIELDDNSRIDPFSDGEMIRRLVIDIWYPSDDTSGKRRSPWFRSHSLFVNSLADNYNLPPMLFQHLRAVKTNSFIGAAPSANANNLPVVILSPGMPAIVPLYFSFAEYLASRGFVVVGIEHPYAASVVEFSDGSQFHFNKDRVLDLPGVETFEEGARLSMELMADDLSFVIDSLSKLNESGHQLAGIFDLDRVAAFGHSGGGGVVHFASNDDSRIKALLSYDPALFMLNDNEIEEGIGIPSLIIETDEWKFREESGRISDLIESSVFPPLHIKISEARHPDFAMLDHLSPLAHFLDFTGSFMKSGGEYYLYDIIQSFLEYTFGNLSESELLSRLLQRDDVRVFKGIHEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q5</accession>
    <name>I2F5Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1590"/>
    <dbReference type="EnsemblBacteria" id="AFK07258">
        <property type="protein sequence ID" value="AFK07258"/>
        <property type="gene ID" value="Theba_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1590"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498568_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4185" evidence="1">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="1">
        <location>
            <begin position="284"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="546" mass="60834" checksum="63A6D7117A184460" modified="2012-07-11" version="1" precursor="true">MIRVALLLLSVVLISSFLLATSLKDVTELEMVAKLTGPNAINNTLKYDVFGTDLGHSFNDGEITYFVFGDTFGINKTNWRKNVMAFTTDQDPSDGIIFEGFITGDGASTYAFSDNTVRLNVVKGADLWSSVDLAPKLLKSQLPGEWSIETRIESNSAPVGATNLCGLLFFSGVQNWIMWGHLGNRTMEASGIIGGKFVKIAEVASLYPYLRIENRLFSNTYVFSYSQDGENWIEAGTFDDKEGFLNSARYGIGAKEWGTSDYEVIFTDIAENSVNFSARELREAFYWGGPGESSGAAKELIHSTPGDITAIPTNGVAVNSRLYLHYMMVNYWGEPGRWNTSYSGLAVSKNGGRTWDVLDSVKWGSESNFAQVGIAKASQWPKIPDGCDVNSDTLFFFGIPSGRFGGVKLMKVDGEEIEKIDAYRYFSGLDNSGIPQWSSKEEDAEIIIEAPVGECSAMYNHFLGKWIITYLNEQSHDLEIRESPNPWGPWSKPHQLVSSREYSGLYGAFLNPLFVENDGEYIYFTMSLWTPYNVYLMKVRLIKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T7</accession>
    <name>I2F5T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase, C-terminal domain of histone macro H2A1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731189.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1626"/>
    <dbReference type="EnsemblBacteria" id="AFK07290">
        <property type="protein sequence ID" value="AFK07290"/>
        <property type="gene ID" value="Theba_1626"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1626"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049707_1_1_0"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="229" mass="26138" checksum="A7E8EE4703554514" modified="2012-07-11" version="1">MITVYKKSVFAAFEEENVPVIANTVNTEGVMGAGLALEFKLRFPSYFDNYRERCSHEGPLPGSAWIFRGDIFPRIISLFVKEDWKMPSKISWIRSSLKRAEEIITESNFERVALPLAGAGKGGIDPQTSENITREVFESSKAEILLCLDKSPSKNEESMIKQLRAMSEYELKCLTLRPSIIKRLLDKREDVTRFREILDIRGIGIKTYSILFNALISREPGHDNQLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5W3</accession>
    <name>I2F5W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane complex biogenesis protein, BtpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1653</name>
        <name evidence="3" type="ORF">Theba_1730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="2">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731211.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1653"/>
    <dbReference type="EnsemblBacteria" id="AFK07316">
        <property type="protein sequence ID" value="AFK07316"/>
        <property type="gene ID" value="Theba_1653"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07387">
        <property type="protein sequence ID" value="AFK07387"/>
        <property type="gene ID" value="Theba_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1653"/>
    <dbReference type="KEGG" id="mpg:Theba_1730"/>
    <dbReference type="eggNOG" id="COG0434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075239_1_0_0"/>
    <dbReference type="OrthoDB" id="1616314at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="272" mass="29615" checksum="F432FC87BC1B0D5A" modified="2012-07-11" version="1">MTTITEFNQLFGTSKPIIGMIHLKPLPGSPVYDGEGLRKVIDHALDEAGKLIEGGVDGVQVENYNDPSYFPDVAAPETVSSLSIVAHEVHKAFPDTPMGICLLADPIASIAVAHSSGAKFVRATVFTEASVDVSGLAIRRPHEILRYRKFLDPSIRIFADVHIKHSAPLAMRPIEESAYDAAYFLADSVIISGKHTGFETPLEDLKKVRGVLPNYPIMVGSGMNKVNAGKIFEVASGAFVGSTFKVDGDSYKSVDSERVKEFMKVIKEIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Y2</accession>
    <name>I2F5Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07335">
        <property type="protein sequence ID" value="AFK07335"/>
        <property type="gene ID" value="Theba_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1675"/>
    <dbReference type="HOGENOM" id="CLU_2206907_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="107" mass="11634" checksum="396CF9511FFE366A" modified="2012-07-11" version="1">MTESSLFAITVSCHPTEPVLKPCAKMLLFGVSCSGSSRTCFGILVLKGKPWLGVGGRRLERAKDQLQDAVCQEGEEGNFKPCLIEDEGGPLEAAMQVEASNHRKLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F610</accession>
    <name>I2F610_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1704</name>
        <name evidence="7" type="ORF">Theba_1771</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
            <strain evidence="6">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731257.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1704"/>
    <dbReference type="EnsemblBacteria" id="AFK07363">
        <property type="protein sequence ID" value="AFK07363"/>
        <property type="gene ID" value="Theba_1704"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07426">
        <property type="protein sequence ID" value="AFK07426"/>
        <property type="gene ID" value="Theba_1771"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1704"/>
    <dbReference type="KEGG" id="mpg:Theba_1771"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="280" mass="31517" checksum="E1B36F5960F6CDB9" modified="2012-07-11" version="1" precursor="true">MKKRSLWKTLILFAVLGIISLFFLIPLIWVVASALRPASPLYEYANPLTWKSFIPTQPTLENFVHIFVNLNFGRALMNSLFVSVSTIVLTVLVSSMAGFALAKFEFRGKAALFTIVLITFMVPFESIVIPLYILIKQLHIDNTYWALILPGVANGLAIFLFRQFFSEVPSEIMEAARIDGASWFRIYWRIVLPLSVPAIVTVIVMVFMFQWNSLFWPLVATHSSRFEVVQVAIAAHRSTENTSWANLFSSAIAGSLPPVILFLFLQKYFVRGISGTGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F653</accession>
    <name>I2F653_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1683</name>
        <name evidence="6" type="ORF">Theba_1750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
            <strain evidence="6">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731238.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1683"/>
    <dbReference type="EnsemblBacteria" id="AFK07343">
        <property type="protein sequence ID" value="AFK07343"/>
        <property type="gene ID" value="Theba_1683"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07406">
        <property type="protein sequence ID" value="AFK07406"/>
        <property type="gene ID" value="Theba_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1683"/>
    <dbReference type="KEGG" id="mpg:Theba_1750"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="26339" checksum="AD93FE63B74AABC4" modified="2012-07-11" version="1" precursor="true">MEVLKTTGLRKVYGSGANAVTALKGAELSVEEGEFIAIVGPSGSGKSTLLHLLAGLDRPTAGSVHIDGKNLYAMTDTQLSIFRRRRIGFVFQFFNLIPVLTARENIELPLILDERKVDEPYLNELIRLMKLEDRVGHLPSALSGGQQQRVAIARALITKPAIVFADEPTGNLDSKTSQEVMDLLKISARKFHQTLVIVTHEEDIAERANRIITLEDGEIVSDYSNTDVGNVFSSALGGQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B5</accession>
    <name>I2F6B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488419.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1817"/>
    <dbReference type="EnsemblBacteria" id="AFK07468">
        <property type="protein sequence ID" value="AFK07468"/>
        <property type="gene ID" value="Theba_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1817"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_0"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="327"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="448" mass="48140" checksum="563FF8F29A6A74E6" modified="2012-07-11" version="1">MKKDVVIVGGGPAGIVTAMTAKKTYPDKSIVVIRREREGVVPCGIPYIFHTLPTVDANTMPIKGAEDLGIDFIFDEVDEISTDSKMVKLSGGESIEYEKLVIATGSQPIFPPIKGSKLPGVFTIAKDREYLKSVYAAAKSAKKVVVVGGGFIGVEVSDEILSDGKEVYLVEAVDQILMAAFDKEFGTMVSERLEKKGMKLRTGMKLCEIKGEDKVSGVVLDNGEEIEADMVILSIGYRPNVKLLENIPVHRGITGGIWADEYMRTSVQDVFAAGDCVEHKCFFTRKPSRLMLASTAAFEARVAGSNLFSLKMVRENHGNLGVFSTSVAGLTVAAAGLTECTAKMENFDYVVGVAKGIDRHPGSLPDKSEIFVKMVFSKESGILLGAQMAGGKSVGEMINIIGLGLQKGITVNDFLTMQIGSHPLLTAAPTSYPLTLAAENALMNLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C4</accession>
    <name>I2F6C4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">Theba_1826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731301.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1826"/>
    <dbReference type="EnsemblBacteria" id="AFK07477">
        <property type="protein sequence ID" value="AFK07477"/>
        <property type="gene ID" value="Theba_1826"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1826"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_1_0"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="419" mass="44990" checksum="840F7FF23BFB1A83" modified="2012-07-11" version="1">MRLLPSKKVVGEIAVPPDKSISHRALMMCSMSSGVSVVHNLLESEDTLRTFRIIGELGGNFRGGFDRMEISLASWKESLRPLDCGNSGTTARLMAGVLSGKEGFHVLFGDDSLSGRPMERVVRPLKEMGASISARQDSLLPMCITGGKLSGSEHSLSVASAQVKSAILLAGIQAEGTTAVTEPHCSRDHTERLLRSMGAKISVSNKRVEVEKSELLPIRFSIPGDVSSAAFPIALAVLHENGKVTIREVGLNQGRTGFLRLLIKMGADIEMEVEESLPEPVGTIVARSSRLIGVEVGSDLIPSMIDELPLIALAGVFAEGTTTVRGAGELRKKESDRISVTVQNFRRIGVEILEHEDGFSVEGPQRITGGKVDSYGDHRIAMLFSLAGPLSREGVEVTNSNAVNVSFPGFFKTLEEVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G3</accession>
    <name>I2F6G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488305.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1866"/>
    <dbReference type="EnsemblBacteria" id="AFK07516">
        <property type="protein sequence ID" value="AFK07516"/>
        <property type="gene ID" value="Theba_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1866"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136738_0_0_0"/>
    <dbReference type="OrthoDB" id="1889095at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="165" mass="18454" checksum="FE4AF41A77A87589" modified="2012-07-11" version="1" precursor="true">MKRSLRFILIVIMVSAVGAIVVSEGGAGPSEPAKIAFANMQKVLEATKDWVTLNIDYQKDTKFYQGQLDTLSQEYQDLANSGASQDALLQKQQEILTKKSQYEQTLETTYNAKLQVIMEQVNKRIKDYATFVGIDMVLSSEVVVYGSSAYDVTDAIIEYMKGFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H8</accession>
    <name>I2F6H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731334.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1881"/>
    <dbReference type="EnsemblBacteria" id="AFK07531">
        <property type="protein sequence ID" value="AFK07531"/>
        <property type="gene ID" value="Theba_1881"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1881"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="576" mass="64928" checksum="0B5A3CCD22063BAF" modified="2012-07-11" version="1">MIRKFMAYYRPHLGLFLLDMACAFMIAGIDLVFPRFTTLALDDYIPSGNMRGIVIIAAIMAFLFVLRAVFNYVVSYWGHVVGVRMEYNMRKDIFSHLQTLSFSYFDKVRTGKIMSRIVNDLREITELAHHGPEDVFISTVTLIGAFIILMQNDWRLTLVVFAYIPFMVWYGVRKRQKMAKAFRLVRKKIANVNAQLENSISGIRVAQSFTNEEFEKSKFDLGNQEFKESRQFAFKSMAEMTTGVDLMMNMLKVTVLAFGGYLTYSGEITVGAFVAYFLYVDLFLQPIRRLMQFAQQYEDGMSGFERFVEIMETKSSITDSPDAVELNGVRGDIRVEKVSFAYDGGENVLTDINLHIPAGKMVALVGPSGGGKTTLCHLIPRFYDVKSGRITVDGVDIRDVTIHSLRTHIGIVQQDVFLFAGTIRDNIAYGKGDATDEEIIEAAKRANIHDFIMSLENGYDSYVGERGVMLSGGQKQRISIARVFLKNPPLLILDEATSALDNETELKIQESLEALSKGRTTLVIAHRLSTIKNADEIVVITNNGIIERGSHDELLEKGGHYAGLYRAQFKGYIPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I1</accession>
    <name>I2F6I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731336.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1884"/>
    <dbReference type="EnsemblBacteria" id="AFK07534">
        <property type="protein sequence ID" value="AFK07534"/>
        <property type="gene ID" value="Theba_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1884"/>
    <dbReference type="eggNOG" id="COG2403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046378_0_0_0"/>
    <dbReference type="OrthoDB" id="414225at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="445" mass="49872" checksum="5D71E7C86DD7543A" modified="2012-07-11" version="1">MERKKVLILGAAGRDFHNFNTYYRDNEEFEVVAFTATQIPGIDGKKYPAELAGRLYPNGIPIVPEEEFGKLIDEHKIDQVVLAYSDLPHQYVMERAAIANAHGADFILLGPSKTMVKSSKPVISICAVRTGCGKSQTTRRVLDILRAKGKKVVSIRHPMPYGDLVKQKVQRFADYSDLDKHECTIEEREEYEPHIDRNAVIYAGVDYEAILREAEKEDVDVIIWDGGNNDFSFYKTDLYITVTDPHRAGHETTYYPGFTNLMMADVVVINKEETASPEDIDIVRRNIAKFNPDAIVVDGASPITIEGGKSSEIKGKRVLVVEDGPTLTHGGMKYGAGWVAAKKFGASEIVDPRPYAVGSLVSTYEKYNHLDQILPAMGYGEKQMKELEETINKADVDLVIIGTPIDLRRVIDIKKPAVRIGYELQEIGKPDLEEIIEDFLKEHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K0</accession>
    <name>I2F6K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731355.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1905"/>
    <dbReference type="EnsemblBacteria" id="AFK07553">
        <property type="protein sequence ID" value="AFK07553"/>
        <property type="gene ID" value="Theba_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1905"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="272" mass="30703" checksum="B18D514DA12F9F4F" modified="2012-07-11" version="1" precursor="true">MKKVPTIILYVFLFAASILWIYPYVWMLLSSFKPTNEIYSGFLPSQFTLDNYRFILEAADKMERPFIQALGNSIFISVTVTLGVLVSSALVGFALSRLNFKGRNAVFNFIIFQMIFPGFLFIVPLYVLIKNLGLIDTRTALILPSLVSAWGVFMFTQSFRAVPNEYLEAARMDGANDLWIITKVLVPLTSSTVSIVGLFTFIGIWDNFMWPLIVVSDYSKMPLSVLLASFNMQYGSYLGPVLAGSVLQTMPMVVIFLVFRKYFLQGISMSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M3</accession>
    <name>I2F6M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731378.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1930"/>
    <dbReference type="EnsemblBacteria" id="AFK07576">
        <property type="protein sequence ID" value="AFK07576"/>
        <property type="gene ID" value="Theba_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1930"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058185_0_0_0"/>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="39877" checksum="A4B8123E9A6C4EBD" modified="2012-07-11" version="1" precursor="true">MEKDLKKEVTKFVLLAAGFLVFYFLPFGSQYVQDAIISGFTMLGSYAREHVLLCLVPAFFIAGTITVFIRKDSILKLLGPDARKIISYPIAAISGGILAVCSCTILPLFGGIYKRGAGLGPAVAFLFSGPAINVAAIFLTGSAIGWEMALVRILGASTSAIFVGLTMQSIFREKGSGGFATQESDDHVSWPEAIGFLGLQMTFLIVGGLAIDPIVKASILIISAIVVFVMAIRFKGELRNQWIGETWDFAKKILPYLFFGVFAAGIISSALPQSVVESLLGGNRFVSTLFASVFGAFMYFATLTEVPIVQSLMFLGMGKGPALALFMAGNSLSLPSMIVITKLLGKKRAFTYFGLVVLFSTLWGFIYGSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P1</accession>
    <name>I2F6P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731393.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1949"/>
    <dbReference type="EnsemblBacteria" id="AFK07594">
        <property type="protein sequence ID" value="AFK07594"/>
        <property type="gene ID" value="Theba_1949"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1949"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437938_0_0_0"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="SSF141066"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inhibitor_I42" evidence="1">
        <location>
            <begin position="312"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I42" evidence="1">
        <location>
            <begin position="419"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="624" mass="69834" checksum="E9DD41F5F5F8CECD" modified="2012-07-11" version="1" precursor="true">MRTFFVIIILAFSASCLAYEGQILFSGNEIHYEVEEADGEVVILIGDGPGFSSSYMKGILSGRKTLRYDQLESGSSKNHSDVAIDFQYFVAELASLIFSLEINSFHLLGHGFGSAIAVGFALTNPEGLLSLVMINPRLNLPAIDSALSDLADGESSQSFDKFYYLFGDGPTSELKPVLSRDIINEEIYNLFWGETPTFISGILRGHDFSSGLLDINLPILICSGLNSFPGAKNLLTFQEGSPNIEFVTFMNSGHLPMFEEKKAFKTIVEDFLQRAEENFGHQGQQEMNLDDMSEVPGDMVFGWEDLEKVHELHVGDDFSVKLPSNRGAGYFWKVKSLDENSIRLISDPYYEELKESGGGRDVFDFRVVGSGKSSIEFSFGSLWEETSIRTSSFSINVEKPNIDPIIIDSSDVGKTIVVGLNEPIEVILDSPIDSGLRWRISATTPEVLRQPRENEVKITEPSPYSAGKVAQTFYFEGMNYGQARLRFDYGSLWEDVAPERTFEATIVVAEPVREYVFVQDSDYGRTISIRIDQTVLVRLKKGNEEDCEWQLSSYSAVEPVGDITEVEYMGVRYSVFRLKPTDSGDSMLEFLYFEGEKRREQVDAFKIGLVITEESGQEMSPDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T0</accession>
    <name>I2F6T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488064.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1990"/>
    <dbReference type="EnsemblBacteria" id="AFK07633">
        <property type="protein sequence ID" value="AFK07633"/>
        <property type="gene ID" value="Theba_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1990"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_0"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="388" mass="41454" checksum="58CAF146C3D6B67B" modified="2012-07-11" version="1" precursor="true">MKLAFSIAMRFLSSSKVQTLLIVLGIAIGVSVQVFIGSLIQGLQKDLVDTTIGSSSQVTITSSEEDNRVADWESIISEIDSLDLPTELTALSASADLPVFIDSGNRTLSVLLRGLQFPESNAIYKIDTRLVDGKIPENYREILIGKGLKEDLEVKIGEKITIFTPDRTVETLEVVGIFDLGVASLNRNWLISTIDTAQSVGDLGDAVTSIEMQVSEVFRADENASLISEALRNPSLQVTDWKSQNEDLLSGLNGQSISSIMIQVFVIIAVSLGIASVLAVTVVQKSRQIGILKAMGLRDSTTSFVFLFQGLALGVVGAVVGIAFGLLLIIMFSTFAVGPDGEPILSISLNYGFVMLSAIIAISASTIAAMVPARRSSKLSPVEVIRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T2</accession>
    <name>I2F6T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase, diketogulonate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731425.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1992"/>
    <dbReference type="EnsemblBacteria" id="AFK07635">
        <property type="protein sequence ID" value="AFK07635"/>
        <property type="gene ID" value="Theba_1992"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1992"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_0"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="31027" checksum="6823F6BADB92F9F3" modified="2012-07-11" version="1">MIYRTLGKNMGEIPAIGLGTWEIGGRDFPDLSRDKEHIDTISRAIEMGYTHIDTAEYYGGGHTEEIIGEAISVFSREELFITSKVWPIHLRKEELHRALEGTLRRLRTDYLDLYLIHWPNPDVPLEETLNAMSEEVVNGRVKFIGVSNFDTPLLKKAVAVSKQPIVNNQVLFNIDDRQPMEELLPYCQSHEITLTAYSPLKRNSLKPSTEKLLKDFAVKYSATVQQIMLAWLLGKEGVVVIPKASKLDHLRLNLEAGSIVLDDDDTRRLDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F758</accession>
    <name>I2F758_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2127"/>
    <dbReference type="EnsemblBacteria" id="AFK07761">
        <property type="protein sequence ID" value="AFK07761"/>
        <property type="gene ID" value="Theba_2127"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2127"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_0"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_synthase" evidence="6">
        <location>
            <begin position="139"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="31525" checksum="77F678F24A9B68DE" modified="2012-07-11" version="1">MDEIIGFIRDSIMKYGYKGAVIGISGGIDSAVVGKLAVEALGKEKIFGLLMPERDSSRDTIRDSKLVAKFLGIDFKVKNISSALRAIGTYKLQPPAFLIPQTIKEKYVKHKWEELSSDPFLDDLCNEGNDEFRRGLAYYRSKHRVRMISLYLEAEKRGYAVLGTTNKTELLCGLYVKWGDDSSDIEPIRHLFKTEVIELAGQLQIPSRIIEKPPSPDLIPGVTDENVFGVTIDDLDKSLRRIEGGEVLDPHDTKSMRVLRILESARYRELRNLAISRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F781</accession>
    <name>I2F781_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731552.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2151"/>
    <dbReference type="EnsemblBacteria" id="AFK07784">
        <property type="protein sequence ID" value="AFK07784"/>
        <property type="gene ID" value="Theba_2151"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2151"/>
    <dbReference type="eggNOG" id="COG3884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045466_2_0_0"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="245" mass="29049" checksum="D5B2CF3F4023DBB1" modified="2012-07-11" version="1">MKPVITKEVYKVRYYELDCHWKASVSTLMDYFNDIVTLQTVEIGHGVDIMSKGEYAWLLLRWDVNVNRYPDYMENVVVQTIPYSMDRFYAYRRFEIFDRSDNLIVDANSQWILIDQRKRRPIRIGDQFYALYGIDSDFHQPLSFPQVNDNDSYGEEITFRVRSSDLDTNGHSNNVSYVRWIMETVPDEFAKRSLRRLTIEYKRESREGDEISVESVFENGDEFAEGKHKIISSGRVLSLARTEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F783</accession>
    <name>I2F783_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731554.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2153"/>
    <dbReference type="EnsemblBacteria" id="AFK07786">
        <property type="protein sequence ID" value="AFK07786"/>
        <property type="gene ID" value="Theba_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2153"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299723_0_0_0"/>
    <dbReference type="OrthoDB" id="1068830at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109644" checksum="DC8B02AAE378A43C" modified="2012-07-11" version="1" precursor="true">MKRWMIYLLIAAVAVAIVLIIALPALLNKEPKLQFPVHVVNQGEKLSANLKPFVIDEKIDEVVLELVEGPGTISGFSYVFEPGFSYEGEVRVSIRATDKKGKSSQQEMLINVVRVNRPPEIDTSPIVVREGETVTINLNSLAVDPDGEELEFSVQGPGELHGSAYIYSPGYSDSGKTVLRVLAKDPNGNETARDIELEVIDVNAPPVLQLENQIVNEGEVLSVDISSKVVDEDNDKVVLSLEEGPGEITEGVFTYEPSYSDSGTETVRIKASDGSGNDVFSGFEILVIDVNRPPKSLLSDMNVNEGESLSFDLLSRVVDPDGDNVTFSLEGPGEIVDGSYIYNPDYSDAGDKSVVLILEDEKGATNTASFMVRVNDVNRPPQISIPDQSAKEGEQLKIYLKGFIFDPDGDEVTFEIADGPGFIEDDHYLFTPDFDSEGIHEVTLTAKDNKGLESVGFFKVTVENVNRSPVTLSPSINTSIMESFTLDLDLGSLFVDPDGDDLQFEVEGYGIVVDNSYQYSPGYNDKGEKVATVTATDPYGLSDSLVIRIDVKDRNRNPESSIEEMKTSIHEGSSLKIDLRPLFSDPDGDELIYSLSGIGEIEGSNYSYSPGYDEAGEKNVIVTASDNNGGSLSLPIIISVIDVNRPPQISIPDQSVKEGEQLKIYLKGFIFDPDGDEVTFEIADGPGFIEDDHYLFTPDFDSEGIHEVTLTAKDNKGLESVGFFKVTVENVNRSPVTLSPSINTSIMESFTLDLDLGSLFVDPDGDDLQFELQGIGSISANSYIYTPGFNDSGEKTATVTAIDSNGSSQSLPIRIEVRNLNRPPDVFLPDCIAEAGKEFSLYLRAFATDPDGDALRFNLISGPGEVVVDRYFFLPERADIGEREVILEVSDELGMKTKKRFRLEVIASEKVVRVSYALPLFSSENVRIVAGEYEIVSDRKQAVIKTNWEFSFDEIRFYSINESEETLIGTAIFDSTDDSLNRKIYSPSGDYVGNIILVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E0</accession>
    <name>I2F7E0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcvPA</name>
        <name evidence="5" type="ORF">Theba_2212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731604.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2212"/>
    <dbReference type="EnsemblBacteria" id="AFK07843">
        <property type="protein sequence ID" value="AFK07843"/>
        <property type="gene ID" value="Theba_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2212"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_0"/>
    <dbReference type="OrthoDB" id="870147at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="448" mass="49619" checksum="1E85A76B000BABD9" modified="2012-07-11" version="1">MPEFPYLPQTKKDIDEMMEVVGVKSISELFSDIPKRFEVDISLPESKDEFTVLRDLSELSKRNLTLNDMSVFRGAGVYKHFIPSAVQAIASRGEFLTAYTPYQAEVSQGTLQMLFEFQTMICELTGMEVANSSMYDGASAVAEAALMAVRVKGGKKVLVSEALHPEYVETIKTYCFGSDIDVETVAFDSESGQIDVTDLQKKLTEDISGFVLGYPNFFGIIENLSEIRSTIGENTMMIVSTNPIALGILEAPGMLGADIVVGDGQPLGNAPSFGGPGLGFFASKESYIRKMPGRIIGETKDNDGRTGYVMVLQTREQHIRRSKATSNICSNHAFNALIASIYMSMIGSEGLREIAKRSFDKAHYLSERINRTDHVSLVFTGPFFNEFVARFDCDLKEFNKELLKDKILGPLELERFNEKLKDCGLICTTEANLNEEVEFFAGRLEAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E6</accession>
    <name>I2F7E6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">Theba_2218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487663.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2218"/>
    <dbReference type="EnsemblBacteria" id="AFK07849">
        <property type="protein sequence ID" value="AFK07849"/>
        <property type="gene ID" value="Theba_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2218"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_0"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="89" mass="9997" checksum="D69D2CC9C1F782C5" modified="2012-07-11" version="1">MKVVPLGTRLLIKPYEEEKKTSGGIVLPDAAKEKQMTAKVIAVGEKVEDIDLKENDKVLYSKYSGTEIKIDDDDYIIIDQDDILAKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J5</accession>
    <name>I2F7J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase, beta-lactamase superfamily III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731657.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2269"/>
    <dbReference type="EnsemblBacteria" id="AFK07898">
        <property type="protein sequence ID" value="AFK07898"/>
        <property type="gene ID" value="Theba_2269"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2269"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670505_0_0_0"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="71"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="410" mass="45087" checksum="D10B41956922B985" modified="2012-07-11" version="1" precursor="true">MLGPIGKSLSRSLILCVLVISSFVFGYATYSGFPGEIVSTFEPFLPGEQLAADQMRITFMGTSVVPRLAQQCNSIFVELGNGDSFVFDFGSGVSSNYVAVGIPPSRMDKVFLTHLHGDHVGDLITLYCFGPSQDRKTPLYLYGPSGDSPEEGTLAFAQNLMELMKWHVEAFSFLSTGLKDGRDGYDIIAKELPYMTVGGVAYEENGVRITHFPAVHDRNGSISYKLEWNGLSMVFSGDTIPNYYMIQQAKGVDVLIHEMVVPPEVWASKNSGLKPGDPGWERAVAFALSVQRNSHTSQKAFGYILSQTNPRLGIATHFQANEDTVGPAIEDIRLLYEGAVAIATDLLVINVSKSEILVRKALVSEYAWYPQPYIYPLDQMAPPKYDGPYAQFNDTLLGIIIPEETYGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K1</accession>
    <name>I2F7K1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-C beta-lactamase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731663.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2275"/>
    <dbReference type="EnsemblBacteria" id="AFK07904">
        <property type="protein sequence ID" value="AFK07904"/>
        <property type="gene ID" value="Theba_2275"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2275"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001586">
        <property type="entry name" value="Beta-lactam_class-C_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00336">
        <property type="entry name" value="BETA_LACTAMASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="362" mass="40014" checksum="A58A6DF84BFB64AC" modified="2012-07-11" version="1" precursor="true">MKGISLLLLLFLGSFLLGTTIDDALLESIEALVAETAESKSIPGLSLSVRVGDVITVFDYGYANLEHQIPVTKDSIFEIGSISKTITAVGILQLRERGLIDLDDTIEPFFRDFPRAGEITVRDLLQHSSGIHELTDIEEFSNNMRRDWSPQELIEITSEFELDFAPGTSAQYSNINFILLGLIIEELTGIPYDEYIADNILGPLGMGNSMLGSRKTLVYGRASGYRLSEGVLENAEYESLVSPFASGAMISTSEDLVKLTRVFTPDLLLSKQSIDEMISQTVLRNGELWPNDKSMTYGLGLDMLYFFDRFVPGKTGGISGFNSYFLYLPDRDLAVAVTANLDDSLREIVLLAMEVADLLRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L2</accession>
    <name>I2F7L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731670.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2287"/>
    <dbReference type="EnsemblBacteria" id="AFK07915">
        <property type="protein sequence ID" value="AFK07915"/>
        <property type="gene ID" value="Theba_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2287"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_2_0_0"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="5"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="385" mass="41064" checksum="997990A1246856A9" modified="2012-07-11" version="1" precursor="true">MFSLLLVIIYIAFISLGLPDSLLGSAWPVMKDSFNVPLSFAGIVSMIISGGTIAASLMSDRVTRKLGTGLVTSISVAMTAMALLGFSLSRSFVVICLFAVPYGLGAGAIDAALNNYVALHYASRHMSWLHSFWGVGASISPYIMSFSLGTKLGWRGGYATVSVIQIVLTIILFATLQKWKNGKMDFGDSGKTSSKPLTITQAVKIKGVPSVLIAFFGYCALETTTGLWASTYLVEYRGVDVETEAIFSSLFNPGITVGRFLNGFIVDRFGDKREIRYGISTLTVGAILVGIPFKSEIFALAGLIVIGLSCANLSVIHATPSNFGRENLQAIIGIQKVSTYVGTTFMPPLFGLIANGVNIGLYPIYLAVLAVLMPTITETLNLSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q7</accession>
    <name>I2F7Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731710.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07960">
        <property type="protein sequence ID" value="AFK07960"/>
        <property type="gene ID" value="Theba_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2335"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48663" checksum="CCA18E91BAD6BA3A" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDTLEVTRQRCWQYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFIQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLELHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTFRVRSCKDRNGRIFYGFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSRLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R0</accession>
    <name>I2F7R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731713.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2338"/>
    <dbReference type="EnsemblBacteria" id="AFK07963">
        <property type="protein sequence ID" value="AFK07963"/>
        <property type="gene ID" value="Theba_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2338"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_48_5_0"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657680" evidence="2">
        <location>
            <begin position="27"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="515" mass="55703" checksum="35B1D7C2D898851F" modified="2012-07-11" version="1" precursor="true">MRKILSVLLSVLLLSAVLFSNVYSSACNGDLQGVKEALNSGGDINELGYANKSALMVAADSGHSDIAVFLIESGADISIVDDNGYTALHYAARKGLLEVVKILLERGADINARPASSMFYEGYTPLILACDNSKNDVTLEVVKYLVEKGADLERVEYAFRSPLIAAIFSKGTNTVKFLLESGADPNKPAKDGRTPLYLAISEGLPIEGIEALLEYGADVSVGNEYYTPLQLAVSKSKNDVAIKLIEFGADYWAVDEDGNTLLHRAAGKGSTKNIEMFVKLGIDINARNNEGKTPLHIAAEDDHFKNVKLLISLGADVLARDNNNYLPFHLHLAVYEEDVEVIEQLLSAGISVDNNEVETGISPLHIAAAYGKTDIAKLLIQKGADVSIKAQGGLQPIHAAVGSYGSLEMVDYLLESGANIDAEDDEGRTPIFYAVVDYNMEAISHLGEKGANVNHRDHAGMTPAHYAVQDEWDGIEMLTILNNFGLVANVKDNSDKTPEDYAASEEIKEFLKTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X3</accession>
    <name>I2F7X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multisubunit Na+/H+ antiporter, MnhC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731767.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2409"/>
    <dbReference type="EnsemblBacteria" id="AFK08026">
        <property type="protein sequence ID" value="AFK08026"/>
        <property type="gene ID" value="Theba_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2409"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_2_0"/>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="119" mass="12940" checksum="DA962271D89986FC" modified="2012-07-11" version="1" precursor="true">MTGILVIYFSIIGMLVGAVGMILSKNIIKKILSLGIVETSVNLMYTGISARGGIIPPIISGDFSNAVYADPIPQAVIITGIVISFALLCLSLVFAIIIYNKYHTMNVETIEMIFEREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y1</accession>
    <name>I2F7Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489918.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2418"/>
    <dbReference type="EnsemblBacteria" id="AFK08034">
        <property type="protein sequence ID" value="AFK08034"/>
        <property type="gene ID" value="Theba_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2418"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="36344" checksum="46E9EBFBA33C0EA7" modified="2012-07-11" version="1">MDNILTVENLKLYYYTSKGVVKAVDDISFTLKKGETLGLVGESGCGKTTTGFALLKMPTPPGKIVGGRIEVDGIDITPLRENEMRRNIRWEKISMVFQGAMNTLTPVYTIGKQMMETLQEHREMERDEARKRIEKYLNLVGLSGDIVKRYPHELSGGMKQRIAIATALFLEPKVIICDEPTTALDVIVQAQIINLLKDLKEKLDLSFIFITHDLATEAEVSDRIAVMYAGKIVEIGTNQQIYGEQGPCHPYTKNLLAATPRLHERVSELSFIPGAPPDLLEPPSGCRFHPRCSLAMDKCKEEEPPLIEIEDEHMVACWRCEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F804</accession>
    <name>I2F804_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NosD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731792.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2444"/>
    <dbReference type="EnsemblBacteria" id="AFK08057">
        <property type="protein sequence ID" value="AFK08057"/>
        <property type="gene ID" value="Theba_2444"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2444"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876629_0_0_0"/>
    <dbReference type="OrthoDB" id="1177619at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658601" description="NosD domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="NosD" evidence="2">
        <location>
            <begin position="76"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="317" mass="34400" checksum="18220583AFF18C1D" modified="2012-07-11" version="1" precursor="true">MKMLFFMLLSILVFVSTVPARDSAKVLIVGDPDGQYKNIQAAIDAANPGDTIRILSGTYKESLSISKEIKLEGSSRDEVTIMPEEGKDLGIFVRGAKNFSIRSVTVIASGAAINVSRSSGQIIDVLIAGGRFGISFSGTGMTLEVLDSYITCYDGMDNEEYIEARLAGIYAYGNATLIAKNCVFERNGVGISLTNDLKYNITGCTFKRNTVGVSLGGNATGSLSENVVTENIENGILINSSSETRLENNIFFGNIWHGLDLYLNRCTECECGGDEFNGTVVGSGNRFESEDEICPIDFWDESFYSFDENLGKLADKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F818</accession>
    <name>I2F818_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2460"/>
    <dbReference type="EnsemblBacteria" id="AFK08071">
        <property type="protein sequence ID" value="AFK08071"/>
        <property type="gene ID" value="Theba_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2460"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_5_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="120" mass="13898" checksum="056D46D653E46FC0" modified="2012-07-11" version="1" precursor="true">MRNMRGRRMGMGRSWIELYLLLLIAEKPAHGYELSSRINDFEIPIFGVGQMGSLYRVLGSLEEMGLITSEWDTEDAGPAKKNYKITRAGLEYLKTAEVKIKRFRENVDKFLDRLNNLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F852</accession>
    <name>I2F852_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731837.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2497"/>
    <dbReference type="EnsemblBacteria" id="AFK08105">
        <property type="protein sequence ID" value="AFK08105"/>
        <property type="gene ID" value="Theba_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2497"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_0"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="236"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="606" mass="68410" checksum="206A0BAEB68AC13F" modified="2012-07-11" version="1">MKIFKNGNLMAVTDERGIIDCESEKAAGLYLEDTRFISRIILKASIYLKRLHVDFSWDRIEVIYLGRSRPEVPHFDILLSETLRVEGNTLYAEMTVRNYSLEEVQLTFNYEISCAFEDIFTIRGENDAYSGLETSRTVSASSLNSLEYESDYEKDVIENSLPSLSLKLRPGQSATVSGKLRLSKAVKKEEIFKDMLSERPVGNLQLTRNVNQIGESEIGDLKMLMIPTVYGDFPGAGLPWYATVFGRDSLVFGLQTVDLLPEITRNILKIHSLLQSCEEETHSEAQPGKIVHETRLNELSLSGRLPFERYYGTIDATLLFIMLSQRYYRRTGDLDFMKSIEKNIMAAAKWIDEYADPDNDGYVEFAPSGGGLVNQGWKDSADSVNFADGRFAEPFLALVEVQGYLYEAFKCLEKLVVLFDKQEMASLYASKAAILKINFNRDFWLENESYFATALDKNKTPVDSITSNPEHCLMIGIVDEDKADALADRLFSEDMYTGWGIRTLSSKMKRYNPFSYHNGSVWPHDNSLILLGLINYGFSEKAKRLASDLLRAKEKYRDNRLPELFSGLSSSETAGSLLEYPASCSPQLWSIGTLFVISSVVAPDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F864</accession>
    <name>I2F864_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731849.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2509"/>
    <dbReference type="EnsemblBacteria" id="AFK08117">
        <property type="protein sequence ID" value="AFK08117"/>
        <property type="gene ID" value="Theba_2509"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2509"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1683937_0_0_0"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="17649" checksum="E9A57C5A8F6363F1" modified="2012-07-11" version="1">MDGFCIESADQIRELWSKTYNTEGKPDWSHILPYYDDNILFKDTIQEIRGIEEFKKMTERLAERSKELKMAVLRVIKEDNVVFVEWEMTILFKKTRTSVIYGASRLSISEGGKIIEQRDYYDLWGDIFDNIPSFRKPYRRFMRKHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A8</accession>
    <name>I2F8A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731882.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2561"/>
    <dbReference type="EnsemblBacteria" id="AFK08161">
        <property type="protein sequence ID" value="AFK08161"/>
        <property type="gene ID" value="Theba_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2561"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_2_0_0"/>
    <dbReference type="OrthoDB" id="1554133at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="605" mass="66613" checksum="28F3E2EC27A21A7C" modified="2012-07-11" version="1" precursor="true">MSSKFLNLLDGTMFFNAFSSGATAVIREQNDLNRINVFPVPDGDTGTNLASTMRSILELTDVSHSIGKTTRSIADAALMGARGNSGAIFAQYMHGLSTIIGDRDSIDRKTFAKAAHEAISYAYDAMVTPVEGTMLTVMKDWAEALIAIEDSERSFFEMVERSNEVALKSLEETPEKLAVLKKAGVVDAGAKGFVAFIEGIKTFLSGRGVNLEDEIIPDIELKKHVHIDEGNIKNRYCTEAIIEGSRLDVNGIKSIISQFGDSALVAGTDTKARIHVHTNEPAELFFKLKDFGTVTQQKVDDMEMQYRVSQKRKYPIALVVDSVCDLPKEVIDYYQIQMVPLYLNFGKSQYLDKITLKADQFYTLLDTTEDYPVSAQPGLNTFQNLYHFLGTHYDSIIAIHVSDKLSGTWNASTKAAERMKDKKISVINSRHVSGSIGLLALTAARMIEEGRSHDEIAKTIESLSKNTRIFVSVNTLKYMVKGGRVSPVLGLVGKAMNLKPIVSVDKEGNSKLYGKAFSKLGNMKKILGFVEELNRKCSVVSYNITHAHAHKTAKAYEESLMKLLGKKPEYIMEVSPVVGISAGVGAVSVSVLCERDTWSPDVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C3</accession>
    <name>I2F8C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose-5-phosphate 4-epimerase-like epimerase or aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731894.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2576"/>
    <dbReference type="EnsemblBacteria" id="AFK08176">
        <property type="protein sequence ID" value="AFK08176"/>
        <property type="gene ID" value="Theba_2576"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2576"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_1_0"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="23662" checksum="84860E7B584E4434" modified="2012-07-11" version="1">MDLRKELVLFARLAWDRRLTESTGGNMSVRNGDHFVITPTTMVKHFLTEEDLVEVDLNGRKVSGRREPSSEYRMHLKIYRECEDVVSVFHAHPVYATTIAVQQKKFPVNILPETALMLAPITYLPYRMPGTDDFAEVFDEGLKLGSRTFVLRNHGVTVGGSSIEEAYAKLETLEFLAQITLLSGAKPGYLEIPSEDVEKFLKKIRGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F6</accession>
    <name>I2F8F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2609"/>
    <dbReference type="EnsemblBacteria" id="AFK08209">
        <property type="protein sequence ID" value="AFK08209"/>
        <property type="gene ID" value="Theba_2609"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2609"/>
    <dbReference type="eggNOG" id="COG3876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033227_1_0_0"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="391" mass="44200" checksum="D1AE4870E4B44A9F" modified="2012-07-11" version="1">MKVKLGIDCLLESDILKKKRIGLLTNSSGVNGDLKINVDLMLNGGFNIVKLFGPEHGISGAAADGVSVNNAVDPKYGIPIYSLFGDVIRPTEEMLSGIDAFVYDIQDVGLRFYTYLYSLVYSMEECAKRGIEVVILDRPDPLSCKIAGPTIKKRLDSIVGGYGLALRYGMTVGEVAKYFNKVFDIGADLTVVPMENYEKYMYYDETGHLWSTPSPNIPSLEHAILYSGFCLFEGTNLSMGRGTVHPFKYIGAPWIDSAPLYKELKEHDHPGVAFRERSFIPGAFKLHDQPCNGLEFYVTDRNAIKPLELALDIIATLMKLWPEKFDWDVHYHGTSIPLNKMWDGRYHFDLIMGDEQYRERLLEGATAAELSGLWKDEQREFENLVREFRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G3</accession>
    <name>I2F8G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731924.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2616"/>
    <dbReference type="EnsemblBacteria" id="AFK08216">
        <property type="protein sequence ID" value="AFK08216"/>
        <property type="gene ID" value="Theba_2616"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2616"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="36685" checksum="60069FAB1DBFBAC2" modified="2012-07-11" version="1">MARITIKDVAKSLELSVSTVSRALNDKGDVDEKTREKVKNRARELGYTPNMMAKALKGKTLGLLGVIIDDNTNPFYAEVVKGMEREAKKHEFHLLLVNTAADYEEQVFAIEFLQNKGVDGILIAPVDDTKPVEMDGIKVPFVIVGRHFEKSDFCEVYNDEELGGYIATRHLLESGRSNIITVQPDMNIFPTRGRSLGYRKALQEYSAESANSAIELKSSPENAGKVVLEYLESSGTCDAVFAYNDMYALEIIALLRSKGMRVPEEIAVVGYDDIPYSVYVCPTLTSVALDKDWLGRTSTEMLIKMIKGKKIREKRYVQKPVLRVRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I6</accession>
    <name>I2F8I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731946.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2639"/>
    <dbReference type="EnsemblBacteria" id="AFK08239">
        <property type="protein sequence ID" value="AFK08239"/>
        <property type="gene ID" value="Theba_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2639"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_0_0"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="43669" checksum="E1F8188A8EB9B0F9" modified="2012-07-11" version="1" precursor="true">MSRIWNFTSGLFKSEIREFQVMFWSFIFPLILYFILTSVFGSLYGDDTQGISFRVGIVREESLSGLGMILDEVIEDISSENGPFVKKEYGSIDEALIDLKEGKQDIVLVIPEGTSAKIASAAVLQTGEVALLVHYVSGKDSSSIASNVLSEIINEVNLEIRRQSGGEYVDVVTEAKTVSAREEKPFDYREYIFPGVALMMILSVALFNSPIGLIQYRVSGVNKKLYTTPLKPFEYFAGHFAKLIFTMLISLTLLYLIATFVYNVRGPILDIRFILTLLFSMVVTISFGLMIASFSKKLSTVTVLGQTLYQLMMFLGGLYFPVFDLPWGIRWLVYALPTTYLVELSRRVMGYQFAPVSLFWLILVPIIWTAFSTVIFVINFKKVMGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J7</accession>
    <name>I2F8J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731955.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2650"/>
    <dbReference type="EnsemblBacteria" id="AFK08250">
        <property type="protein sequence ID" value="AFK08250"/>
        <property type="gene ID" value="Theba_2650"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2650"/>
    <dbReference type="eggNOG" id="COG1503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694093_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="397" mass="46167" checksum="1A957C4C13EF93EA" modified="2012-07-11" version="1">MDDFKPRVLRRAEMEKELEKLLNVEAEIRSDSYLLTFYFPMENMTRADAERHVKSFILEHLRKDEKLSGMGKINQRIVEAVLTGLGNTKELRRGLAIFVEFRMGEDVKADEVIEGLSIIPLSQVPEKEIYIGKTFDLDQLIWLSSSSIDALIVSLEREKSSFYAMDGNKLSLIKSIENEFIRKKEQEYMEEYSPSPSSGAMYHGNASEKVGRAKEEENRRFLQKIASLIKNDEDLPKDVNYLVIYYSSSFNETMEKFKNEARQLLPYAHPVFVQKTLNQERQLQEDASKLIESVSRKIRREFLHNAKENFEKYVEGWTEVSKAANDRRIDTLFINPTERKRGYVLGRELVYTHAVKDSREVRNVGPWIVRSVVNNDGKVVVVDKELLDCEIAARLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J9</accession>
    <name>I2F8J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative homoserine kinase type II (Protein kinase fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487253.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2652"/>
    <dbReference type="EnsemblBacteria" id="AFK08252">
        <property type="protein sequence ID" value="AFK08252"/>
        <property type="gene ID" value="Theba_2652"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2652"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080653_0_0_0"/>
    <dbReference type="OrthoDB" id="558383at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="331" mass="37703" checksum="DEE0CF4439ED65EC" modified="2012-07-11" version="1" precursor="true">MLYNLNVYIRGDNMSSIPFSRISRFWGLKRKIVLEKKTNARAFIVRSGSIFYVLKRRVASLPSRSCQTELLKYLVQSGLPVSAPIPSGSGEFEVKIGKYVYSLFPYIEGEKADSNISNATPEMAEELGIFTGRLHRVLKEAEGSFFERTNLLKSLTSAIRYFNSTGSFFSRSDMEMIEEFFTDFYKLYYKLPVQIIHGDYHPGNIIVHEGKVSGIIDFDCATREVKALDLAYLIHSVFAEFSRMGSPSLFLYLLPHLLEGYCLENTLSFDERESLGYLLAAISIIQIHYFSANGLSDEANFASTVFRWIYLNNHRIKEKSGLVLTRSKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N2</accession>
    <name>I2F8N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731980.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2686"/>
    <dbReference type="EnsemblBacteria" id="AFK08285">
        <property type="protein sequence ID" value="AFK08285"/>
        <property type="gene ID" value="Theba_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2686"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_0"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="45745" checksum="2D1790BD30A546E2" modified="2012-07-11" version="1" precursor="true">MEFSLDYREGRRVKLEVPAGQVILPAISAEPAEAGSSLTESISMPIGTAPLTSLAESAKSIVFIVEDHTRHSPVLETLDLLRKLFESRGISWDKVSLLIATGTHRQMKPEELQEKFGVFSSDTRIVQHKAEETAKMKDFGEFLEVPIQVNEAIEADLTVGIGSIVPHRFSGWSGGAKIVLPGVASYESVFKSHRMAILKSKADVGVFENEFRELIDETGSRVGLDFIINFYYDINGSTAGTVAGNHVLALRKGVELARKQLLRQYRERTDVTVISSFPSVTDFWQCGKALYTSDLITKDGGDIVMVSSLDEGFGDHPLFASLLKLEENEILEKLDMITTEDPLAYVAAYAVRKVLQKKKVHIVSDTKFAEEFDELGLRVNPDIQSVVDRLICPGKSVSVLQNSLVLPEITTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q2</accession>
    <name>I2F8Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731998.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2706"/>
    <dbReference type="EnsemblBacteria" id="AFK08305">
        <property type="protein sequence ID" value="AFK08305"/>
        <property type="gene ID" value="Theba_2706"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2706"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068890_1_2_0"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="167" mass="18397" checksum="4131BDCEBCAEE1A2" modified="2012-07-11" version="1">MSVENGKNVLVVYYSHDESTKSIAESIAGETNADLLELKPVEKSGGRKVKYIWEGESVSMDPVPDLEPFLLDPDSYDLIFIGSPVWAMSYAPPVESFIRKTKLSNKNIALFCTHEGLMGIVFQELMSKLSENKIVGAIDFYDPIGSGVKYAANASANWARQVLKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G1</accession>
    <name>I2F1G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729947.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0009"/>
    <dbReference type="EnsemblBacteria" id="AFK05764">
        <property type="protein sequence ID" value="AFK05764"/>
        <property type="gene ID" value="Theba_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0009"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_3_0_0"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="116"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="353"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="598" mass="69263" checksum="E22891834B0B77EF" modified="2012-07-11" version="1">MSKLNEREIIEWDLTRLYASLDDETIFEDIKTVLREKDELVRDYRGRISGENISARELRGLLEKSESLLNRAGKLSMFAYLNHSVLTADSATQKLVRKMDDLEAALESGLMFIKLELARVSDDFFSELNECDELKNYRHYFDLVRALRDHQLSEPEEDIIVRKDITGKMAMLNLFDEFTSTFEYRIFIDGEEKVLTESEVENLRSHGDEGIRKKAFESLFRKTEENSVILTNIYNSLAKDWDLDASKRHFSSPISMRNIENEVSDESVQNLIDATTQGYSIVQDYYRLKARVMNKEILLHSDIYAPLADSRDIFSWQEAKNMILEVMGNFDSQSGRIISGFFDGEYIHGSIIPGKRSGAFCYYASPEVHPYVLVNFGGKTSDVLTLAHELGHGLHGVLSSKQTHLNYETPLTMAETASIFSEMLMTDFLLDNISGKAEKLSLISKRMEEILASTARQNMFTRFEMAAHSIISREFLSFKELSDLYFEELKLMFADTIVFFPESKFEWARIPHIFHTPFYCYAYNFAQLLVISLYRMYLEDGDVFKRRYIRLLESGSSDSPEILLKSVGIDISEPYFWENGLHFIQENFLERLRDIIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L3</accession>
    <name>I2F1L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729990.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0065"/>
    <dbReference type="EnsemblBacteria" id="AFK05816">
        <property type="protein sequence ID" value="AFK05816"/>
        <property type="gene ID" value="Theba_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0065"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019091_0_0_0"/>
    <dbReference type="OrthoDB" id="952726at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="592" mass="63953" checksum="787475107313646E" modified="2012-07-11" version="1">MKEAVHKVIFLPSQRTVTAKRGEILLDVLRRESQPISAVCGGRGNCGKCKALVAEGSEAFPLTLTEARLLTRDEIAAGYRLSCQFKVMTDVRVKTEDPAVDSAVSKPPLPKALMREISPLVRLEEFSLSRPDIHDQASDYSRLISALVTEKPRIDRLNLLRRLPHIIREIDYRGRAVMYGSEVIDILPFSDERGIFGVAIDIGTTTLAVYLADLKSGEILAVRSAPNPQSSYGQDVISRIDYTIKRAEGIDELRIAVLKTLNKLIDDLCKESEVSKERIYDTSIVGNTTMIHILLGISPERIASSPFIPVFTGGKVFESRELDLEESIPNSKIYIMPGISAYVGSDITAGILSSGFIEDSGNVLLVDIGTNGEMALKKGDRIFACSTAAGPAFEGGNISQGTIARPGAVDHVWLNGEGIGFSTVNGSNASGICGSGLIDAIAVMIGAGILTESGRIKGEYFELEGPAGIVRINKRDIREVQLAKAAIRAGVSILMDRAGIETRDIDRILLAGAFGNYIDPENALRIGMLPNVPVERVSPVGNAAGLGAVLAVLDSGIRERAENLSNIIYYVELSGRKDFNEIFVDNLALREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N0</accession>
    <name>I2F1N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730006.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0082"/>
    <dbReference type="EnsemblBacteria" id="AFK05833">
        <property type="protein sequence ID" value="AFK05833"/>
        <property type="gene ID" value="Theba_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0082"/>
    <dbReference type="eggNOG" id="COG5426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074816_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010768">
        <property type="entry name" value="GATase1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07090">
        <property type="entry name" value="GATase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase1_like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="248" mass="27936" checksum="31B20472E1D1046C" modified="2012-07-11" version="1">MKKKVLLLGETWTVTKIHTKGFDVVELGGFDDYSVYFKEPMKAFEDIEVTHIPNHQVLSMFPSTAEELAKFNVVIISDCGRNTLTMYPDMFKVPMGPNKVQMLSDYVLNGGSLIMTGGYVDFQGFQGKGNYHGSPIEKVMPVNMMETDDRVEATQGASVKVLNPNHPILKGIDTTWPRFLGYQKVFPKEGSEVLAEIDGDPFIIVGDSGKGRSMAFMSDLAPHWGTDFVKWEYYGKFWHQAISWLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N8</accession>
    <name>I2F1N8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490164.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0092"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="EnsemblBacteria" id="AFK05841">
        <property type="protein sequence ID" value="AFK05841"/>
        <property type="gene ID" value="Theba_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0092"/>
    <dbReference type="eggNOG" id="COG2039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_0_0"/>
    <dbReference type="OrthoDB" id="1927224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="200" mass="22015" checksum="9E9C06B757F60665" modified="2012-07-11" version="1">MILVTHFDPFGGSKINASQIVVELLADIREDIELMSLPTVFDDCFSRLELRLLDNVPEALIMVGQAAGRSLVTPEKIAINWKESPTPDNNGFIATGEKIIPASPDAYFSRLPVDGIVSKLKDEGLPIEKSFSAGAFVCNYLFYRCMDFLTKRAINIPAGFVHIPCIPEQIGPGENRPAIEAEVSARVLSRIIDLAVEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R4</accession>
    <name>I2F1R4_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730032.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05867">
        <property type="protein sequence ID" value="AFK05867"/>
        <property type="gene ID" value="Theba_0119"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1967948_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658614" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="127" mass="13360" checksum="83FDE3234842ED08" modified="2012-07-11" version="1" precursor="true">MKKALSVVLLVTLLTGSMLAGFTMYDAMALGDYHGSKDADNAGFFGAVILGTLSAIFVNTGSKSLPANRVAYINSLTDDPEAIAAYEEAYSFAYSNRIACNTWRGYVIASVISSVIAVITLLMGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S5</accession>
    <name>I2F1S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730043.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05878">
        <property type="protein sequence ID" value="AFK05878"/>
        <property type="gene ID" value="Theba_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0132"/>
    <dbReference type="HOGENOM" id="CLU_2451149_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="89" mass="10077" checksum="2A928653BA5EC356" modified="2012-07-11" version="1">MKSGEIDYEILRIREFGKAMHPRNVEVRVLSYSPSEDSLKKLAESFWSQHGQDVEELTTVFYLPEMNPESAAFAIGSCTKGKGCYVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W8</accession>
    <name>I2F1W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-type ATPase, translocating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730085.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0181"/>
    <dbReference type="EnsemblBacteria" id="AFK05921">
        <property type="protein sequence ID" value="AFK05921"/>
        <property type="gene ID" value="Theba_0181"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0181"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_0"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="878"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="906" mass="99558" checksum="BA6C95A9D60E4318" modified="2012-07-11" version="1">MAKHHQETIEEVIKELGSSSNEGLSGAKAKERIEQYGLNELTEKNRRSAWKILLSQLKSVMVIILIVASVITAFVGELRDTIVILAIVALNTILGFTQEYRAEKAMAALKKMSVPRVKVRRDGKIVEINSTEIVPGDIVILEAGNIVPADMRLIEATNLKIQESALTGESEAVEKTTKPIEEENPSLGDRKNMAYSGTVVTYGRGVGIVTATGMETELGKIAAMLQDTAETQTPLQKNIDQLGKILALIALGIVGVIFVMGLLRGEDLELMFMTAVSFAVAAVPEGLPTVVTIALALGAQRMLKKNALVRKLMAVETLGSVTVICSDKTGTITENRMKVTVVEMAGRTLDFGKENEPDPEALPEDDNKSFEIMLTAAALCNDAEIKPPVHKKQQADVIGDPTEGALVYAAYRVGIEKSDLEQAMPRILEIPFDSERKRMTTIHEIKSNPKGKIPADVPEHLRENAVDQYVAFTKGAVDSLVEVCDRVLEGDEIHELDDDWKRRIIETNNNLAANGMRVLGVAFRPVNSAEVEDKKVEEKNLIFTGIFGMMDPAREGVKESIMTAREAGIRPIMITGDHPLTAGYIAESLTIVDDKSNVKMGREIENLTEEELDRVTAETSVYARVAPEHKLKIVDSLQRQGNVVAMTGDGVNDAPALKQADIGIAMGITGTDVTKEVADMVLIDDNFTTIVSAIREGRTIFDNIHKFIRYILASNFGEIWIMLLGPFFGISLPLAPLQILWLNLVTDGVPALALAVEPPEKDIMKRPPNPTKEHVLANGRWNVILIGLLLSAFSLGVGLVYWMNDINGPWRTMLFSTLVFSQLFFALSVRSRTKSIFNAPFKENPYLMYAVLASFGLQLAVIYVPFMQGLFTTQALGVWDLLLSLALGSAILWIYEIKKLVTRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X0</accession>
    <name>I2F1X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730087.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0183"/>
    <dbReference type="EnsemblBacteria" id="AFK05923">
        <property type="protein sequence ID" value="AFK05923"/>
        <property type="gene ID" value="Theba_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0183"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="27620" checksum="2DF1CAFE94B2FE29" modified="2012-07-11" version="1">MIEIRDLTKIYSGSVKAVDSISLTVNKGEIFGFLGPNGAGKTTTIKMIVGLLQPTSGSISVDDIDVVAHPVEAKSKIGYVADEPLVMDKITGVQYLNLISDVFQVPPKTRAERASKLLQNFKLSDAIKDPVSTYSHGMKQKLSLIAALIHNPDLWILDEPIVGLDPESAFILKQMMRNHVKAGNTVFFSTHVMEVAERICDRIGIINKGKLEFVGTVEELRKLRGQGSLEELFLEVTGSETENGDFAYLDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X8</accession>
    <name>I2F1X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730095.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0191"/>
    <dbReference type="EnsemblBacteria" id="AFK05931">
        <property type="protein sequence ID" value="AFK05931"/>
        <property type="gene ID" value="Theba_0191"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0191"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_2_0"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="125" mass="14456" checksum="12587800C1C2C93F" modified="2012-07-11" version="1">MPVRSLNSSIMKWPSKKAVIDSLDKWSETLKRDSNILRIGYFGSYARGDNGVGSDLDLIVIVKDSKAPFGKRGTEWDLAMLPVPVDLLIYTLDEWNELNKELSYFIKRLREEVKWIFMKDDSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F273</accession>
    <name>I2F273_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Theba_0295</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491766.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0295"/>
    <dbReference type="EnsemblBacteria" id="AFK06026">
        <property type="protein sequence ID" value="AFK06026"/>
        <property type="gene ID" value="Theba_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0295"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086979_1_1_0"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK06026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="211" mass="24127" checksum="1F52F1C76F0254CB" modified="2012-07-11" version="1" precursor="true">MFEMMRNFFCLTPAIAAAILSHEYARFITARRFEATKPEWGGPGFIRRIDPVGLLMFYFFKFGWSRPFPVNYWKLRKAKYFKAILTALSGSIANFSLGVITGLIFYLSGLHRFSTFMPETVSSFPASYLADVVYWTMVINLNTALFNLIPIPPLDGANIVTMLVPESQVNWLVKYELYGILTLLVLSLMGIIQLIMWPITQFIQLLARLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F280</accession>
    <name>I2F280_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEGA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491774.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0302"/>
    <dbReference type="EnsemblBacteria" id="AFK06033">
        <property type="protein sequence ID" value="AFK06033"/>
        <property type="gene ID" value="Theba_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0302"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031368_0_0_0"/>
    <dbReference type="OrthoDB" id="1105830at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4384" evidence="2">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="402"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="470"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="607" mass="67138" checksum="15878FBBF22063D9" modified="2012-07-11" version="1" precursor="true">MKKIILVFLSLFLAISLFGIVSYDLQKVIIVPEEPQGGLEVSIWLDRDIGSLYYSGEEVKTYFKVNKDAYVAIYDITPNGEIQLIFPNGFDRNNFLKAGVTYTLPTENANTRYRLQLTSETGGGKEIFQIVASTMPLGFLDALMAKAEAGDIFPKASSKAEDFVVSKVIPVIDKQEYAVSTTWFYLDIMPSTGRARITTTPSGATIYIDGKMVGTSPLSMDLDDGNHIVTAYKSGFRSETRQFSVISGRTVDVQLDLKKFVSEYQLSIVTNPSDAVVYIDGSLIGRTPLNVTLEEGTKNLSVSKSGYVTYTETLVLNRNISKSITLTPIVQNYQLSVITSPSGADVYVNNAYIGRTPLNVTLEAGTKNLRIERSGYETYSESFMLDRSISKSITLSPLVREYRLSVTSSPSNALVYINGSYQGRTPLNLNLREGTYTVRVTANGYDDFSTSVSLDRDRQVSATLYAKKARLTVETEPTNASVFVDNVYVGRSPLSIDVDAGRHTIRVEKSGYITDSKEVNLAAGTSSSTKIILVEERPVARITISSDPSNARIFINGRDYGRTNRVVELDPGYYEVVLVLDGYRVSVTYRYFGKGDHNLSFNLSRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F295</accession>
    <name>I2F295_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative S-layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730190.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0318"/>
    <dbReference type="EnsemblBacteria" id="AFK06048">
        <property type="protein sequence ID" value="AFK06048"/>
        <property type="gene ID" value="Theba_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0318"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470749_0_0_0"/>
    <dbReference type="OrthoDB" id="554219at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="562" mass="61500" checksum="BCB198531A9C8D44" modified="2012-07-11" version="1" precursor="true">MKKLSILTLIVVAFASLSLGVEYSDLSENHWAYDSVIKTTAGGLFIGFPDGTFRGSEFATRYQLAMTLARFMDYSDAGDAKLQEVVFSLTKKVAGLSLEISDNKKNLVDLTAELRALEATVASLKQSGMTGDFVSLKTFDDTVAFLYDEIDRLSMEAVTANEGIVLISERLDSMSSVPSDVEALKNRATDLEVTVKLLGQAIANLKNDNSEQAEAVADLTSRFEATENVLNSVTSDLFAMRRSMATKDDLSTLESKLAGEMPDLEPYVTNEDLNDKLSLMYTRILKIQDSIAKMPEVKYYDAEIEEIHAAMENADETLEVLFDQVDLNISRLDDLDGKLAELKSELSTKASASDVEAVEGRVTDLEVTTKMLSNAVIAANKRISELDYVTPEQLTAKMNFLYRKLGLAEENLKAELGNLNGELDLLRDEVTDNYEMLEVAFDQIDANIAVLDDHADSIASLEDRTGTLEGKVGVLEGAVDSLESITNTMAIQMFKLDRNKADKSALEAAETRIAALEENDVVIEGKISALEETQKQNVINTNAAIILSFVALAFGAVGLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H0</accession>
    <name>I2F2H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase (MutT family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730242.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0395"/>
    <dbReference type="EnsemblBacteria" id="AFK06123">
        <property type="protein sequence ID" value="AFK06123"/>
        <property type="gene ID" value="Theba_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0395"/>
    <dbReference type="eggNOG" id="COG4112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115729_0_0_0"/>
    <dbReference type="OrthoDB" id="1310481at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="192" mass="22226" checksum="9FFCDAF756E55964" modified="2012-07-11" version="1">MEERVLVVDVDCLGELATRNGLLALPLDEIKKKVERFGRFVRRSEAENDESMRQIIPYAVFRNRDEYLLMKRTKKQGEARLHELYSIGVGGHINPEDGRLPWEAFENGFQREIREEVSVKIHSMGYLGILNDLQTEVSRVHIGVVYIAEVDFGGFNEKEKFTGAMAEIKVLSEYRESMETWSQIVLDYLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J9</accession>
    <name>I2F2J9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="5">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hslV</name>
        <name evidence="6" type="ORF">Theba_0424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730267.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0424"/>
    <dbReference type="MEROPS" id="T01.006"/>
    <dbReference type="EnsemblBacteria" id="AFK06152">
        <property type="protein sequence ID" value="AFK06152"/>
        <property type="gene ID" value="Theba_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0424"/>
    <dbReference type="eggNOG" id="COG5405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093872_1_0_0"/>
    <dbReference type="OrthoDB" id="1129370at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="182" mass="19610" checksum="D3D39635D0C65A68" modified="2012-07-11" version="1">MKTFHGTTILVLRKKGKTVIVGDGQITIGDTVMKGTARKVRKLGDGSVLAGFAGSVADAMTLFEKFEEKLHESNSNLKRAAVNLAKDWRTNKILKNLQALLLVADRESILLISGNGEVIEPDEEVLAIGSGGSYALAAARALLRNSQLEAEEIAVKSMEIASEICIYTNTNFTMETLGGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M9</accession>
    <name>I2F2M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730296.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0456"/>
    <dbReference type="EnsemblBacteria" id="AFK06182">
        <property type="protein sequence ID" value="AFK06182"/>
        <property type="gene ID" value="Theba_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0456"/>
    <dbReference type="eggNOG" id="COG1243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057482_0_0_0"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="30"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="42236" checksum="17E045FB2BDB9E4E" modified="2012-07-11" version="1" precursor="true">MIHSTICKVTQKAFRLRFVEVSLLNSAQSVYNTSMNIIPIFVPHEGCRTRCIFCNEYSATGVTGVPDEKEIVSTVEKYLSFFRHPEDVELAFYGGTFTGFGNQQKYLEVATEFFKAGQIKGIRFSTSPGLISERLVEYLKPYPVNFIELGVQSFDDTVLEKSNRDHNTSDVYKATHLLNSNGIKFGIHLMTGLPEDSESKDIHSTREAIRVGASSVRLHPLVILKGSLLENEYKLRRFSPLDLQESIEILWKMYLLLSTSNVKINRIGICLYGKQIDNVVAGPFHPAIGELVRDRLFLEIVRAFSGEMKRNELRLHNKFKPFFTGHKKGIVEEARKEGILIDFAHDGEEIDVSLYMRRIKERVLEGVYAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N1</accession>
    <name>I2F2N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730298.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0458"/>
    <dbReference type="EnsemblBacteria" id="AFK06184">
        <property type="protein sequence ID" value="AFK06184"/>
        <property type="gene ID" value="Theba_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0458"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_1_0"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="152"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="301" mass="33011" checksum="46B8CB9C218BAE0E" modified="2012-07-11" version="1" precursor="true">MKETDRRSLGLVILATTAVIWGGSYIFTKVAVSSLPPMLLAFLRFAIAVVILFPISLNKRGSFNTVDHKNAALAGLSGITFYFFFENYGLTMTNAADASLIVSTAPILTILLYDLIRKKYDLFEYLGGLVAFSGLSVIIYSGRFADGSSVTGNLFSFGAAVSWTAYTYFYEKIHNSSIWTTLEIMLWGLLFSAPFALSEILLFKRPVVFSFGAVSGILFLGIFASALGYIMWNKGIDLWGGKAATLWVYTIPVFTVIADIVFLGNSPSMLFFTGSALVGAGMLLVIGREYRRLVSHDNTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P8</accession>
    <name>I2F2P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic glycine betaine/choline-binding (Lipo)protein of an ABC-type transport system (Osmoprotectant binding protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730314.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0475"/>
    <dbReference type="EnsemblBacteria" id="AFK06201">
        <property type="protein sequence ID" value="AFK06201"/>
        <property type="gene ID" value="Theba_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0475"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038355_1_0_0"/>
    <dbReference type="OrthoDB" id="770506at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="2">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="33388" checksum="D90645F96C45D7A0" modified="2012-07-11" version="1" precursor="true">MKRLFLITLVVLMATVMSFGQTRLNVGAKNFTEQYIVSSMISQLLEDAGFRVTENFGMSSFVARSALETGQIDLYADYTGTAWPTYLGHEKMIRDPHELYEAVKAEDLENGIVWLDMANFNNTYALAVRRDFAAEHGLTTLEDLAELTHEDPDLLFGIVYEFLERDDGFWPMSEAYGFAVEKRQVKTMEIGLTYEALDKNQIDVAMVFSTDGKLEKYNLLVLEDTKSFFPSYNLAVTVRKEILENNPEIEEILRPISVYLTEPIMTRLNYLVDAAGYEPDEVAEGFLKGLGLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q8</accession>
    <name>I2F2Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730323.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0485"/>
    <dbReference type="EnsemblBacteria" id="AFK06211">
        <property type="protein sequence ID" value="AFK06211"/>
        <property type="gene ID" value="Theba_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0485"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_0"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="462" mass="50592" checksum="EEECDA3426166317" modified="2012-07-11" version="1" precursor="true">MSYSLFKSYLNDEEAKEIRGSLLVMAIPAMAENVLQMLLGISDTAFLGHYDWRIMTAVGTANQVVFIFQAVLVAISTGSMVLLSNSYGANNHRRVDLIAWHAIYLSIAAGLILSFGSFFSDSLLSVLFPSSDSLMQMNGSKYLQIIMAGFPAMSIMIVLGAALRGAGDTKSPLIVAAVANVLNVFLDYSMIFGKFGFPEMGAFGAALATVLSRVVGSVIIIVLLFRNRRISMSRKPRRFSKWLFKEIFVLGLPASIENFRFSLGVLVFANILFISGPQAYAAHRIGIQVESLSFMPAWGMGVAITALVGIYNGGRQRRMSIGVVRQGWFIALAISSAIGLTITLFPDLFISLFTNEPSLIEEGRLPVRIIGLFQVVMGTDYVVTGALRGMGDTSFPMKTSLVAMWFLRLPIGYVLVRYFGLGLFGAWIGIMADMAFRTTLKFIRFYSGKWESTADSIQARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R3</accession>
    <name>I2F2R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0490"/>
    <dbReference type="EnsemblBacteria" id="AFK06216">
        <property type="protein sequence ID" value="AFK06216"/>
        <property type="gene ID" value="Theba_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0490"/>
    <dbReference type="eggNOG" id="ENOG5033D24">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209079_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="58" mass="7026" checksum="B3285697E70782B8" modified="2012-07-11" version="1">MLVLMDTIIHYFYFVMTGFFAILLLKNLFKRERRKGLVYDIVYSYVIMVFILRVIGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R6</accession>
    <name>I2F2R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492117.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0493"/>
    <dbReference type="EnsemblBacteria" id="AFK06219">
        <property type="protein sequence ID" value="AFK06219"/>
        <property type="gene ID" value="Theba_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0493"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657743" description="Dipeptidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="537" mass="60741" checksum="3EBC4F7714AF9BE1" modified="2012-07-11" version="1" precursor="true">MKKVLIILIVALISFASAAVACTILGVGKDAMVNGSTIITHNDDSTSADFRLWIIPAMDWPEGSMRDIVLDSHNYIDYGNYPEVNIGSKGTLIGQIPQVPHTYQYFHSRYSFMNEKGVAVSESTFGIDTSTDYGKEVRKVLWTDSKGIIDCWTAQDIALERAATAREAVRIMGDLVEQYGWSTVGGGGETMTVADGEETWIVEFYGRDIWAGVRIPSDHFTVAANRARIMEVDLEDTENVMASPNIVSFAVEQGWYDPSSGKPFNIAEIYAPNDSLYATRREWRAFDLVAPSLGLSPHDLRFPLSVKPDRLLTVHDIFAIKGDYYQGTDYDLTVGLAAGPWGDPLRYANTGKTGSWERSINMHRTCYVHIGETNSAYAEPFKGISWFGYGAPDTSYIVPLWPIMRELPKFYETGSRYEEFRRDSGWWVNSYVQQMAELHYNLAIQDIRNYRDPKLEVLYKVTPEVQKIATDMYETDPEAAIDFVSNYAFMNAVAWHEEWKLLGDRLLGNYALGYVNFKSSPYPDWWNEAIGYGFPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W9</accession>
    <name>I2F2W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730370.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0549"/>
    <dbReference type="EnsemblBacteria" id="AFK06272">
        <property type="protein sequence ID" value="AFK06272"/>
        <property type="gene ID" value="Theba_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0549"/>
    <dbReference type="HOGENOM" id="CLU_2260412_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="103" mass="11436" checksum="BB6FCC379936E908" modified="2012-07-11" version="1" precursor="true">MKKGNVVTLVLAVLLLSICTITSLFALNVVSSNRKNTQLMLEASIMRGVRVSAEKLLLFSMEHGKKLAVEINGYHLETDEINGSWCVRLDNGDEEEIIFAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X1</accession>
    <name>I2F2X1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ORF">Theba_0551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730371.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0551"/>
    <dbReference type="EnsemblBacteria" id="AFK06274">
        <property type="protein sequence ID" value="AFK06274"/>
        <property type="gene ID" value="Theba_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0551"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077150_0_0_0"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="318" mass="36897" checksum="AF2E3555C187CF43" modified="2012-07-11" version="1">MSEHYLLNYVDCTEYKLPLDLQNIFGRKRETFLEIGFGSGEFILQKAIENPNADYLGVELSMISAKKLLKSISRNHVGNVRALLVDASFALRNILPKDSMSGVYMNFPCPWPKKRHSERRLNTVSFIEKIAKVLKKGGFFQLYSDSEEFVHEMFGEVGKTNCFDDPVLEVNPTVGVGTRYEKKWLDMSKEIFRMKCVRIKCEINGEEDVVRVSNLWIDDIDEKSLQKVDGKSFSKNEIFVKFMGLYRNMDRNTFLIETLTVDRDFSQRFYVNLSRRGNRWLIKLDSQARPFRTKAVKFALRVLSEKIAKKDPGGDQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z0</accession>
    <name>I2F2Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492206.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0574"/>
    <dbReference type="EnsemblBacteria" id="AFK06293">
        <property type="protein sequence ID" value="AFK06293"/>
        <property type="gene ID" value="Theba_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0574"/>
    <dbReference type="eggNOG" id="COG2316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090635_1_0_0"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="182" mass="20447" checksum="CA151412129D4959" modified="2012-07-11" version="1">MISRDHAMQLIMNNIQSKNLIKHVLATEAVMRALAERLGENEDVWAMAGLLHDLDYEFTKDNFDQHGLKTVSMLQNEDLPDEVNDAILAHCEKKDRVKLIEKAIYAADPVTGFIVAAVLIRKGSKLSDIDVDFLKNRFKEKSFARGASREQMASCSEFGMSLEDFLSLSLKAMQEISVDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F382</accession>
    <name>I2F382_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">Theba_0668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730459.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0668"/>
    <dbReference type="EnsemblBacteria" id="AFK06385">
        <property type="protein sequence ID" value="AFK06385"/>
        <property type="gene ID" value="Theba_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0668"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_3_0_0"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="34239" checksum="03ED69904FBDF368" modified="2012-07-11" version="1">MSRQYDERHRSVMIHEALHYLLGGRLTGTYIDCTAGEGGHIRAMLEATEGQAKIIGLDVDSEVLNIAEQNLKDYRESVELFNLSYVDFEIALRQAGVEKVDGFLLDVGVSTFQLKAKGRGFSYELDEPLDMRMNLSQKRTAADVVNSYREDELSRIIFEFGDEKRFARKIARSIVSRRPLFTTKDLHDAIKAAIPPAERYKRRRHFATKTFQAVRIEVNQELENIESTLRKIPGFLNQGGRIVIISFHSLEDGIAKRVFREKSESELKILTKKPVQPSKEEVELNLRARSARLRAAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D3</accession>
    <name>I2F3D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretory pathway, component HofQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730494.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0719"/>
    <dbReference type="EnsemblBacteria" id="AFK06436">
        <property type="protein sequence ID" value="AFK06436"/>
        <property type="gene ID" value="Theba_0719"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0719"/>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224197_0_0_0"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="3898" mass="430080" checksum="B4FBFBFF534A4564" modified="2012-07-11" version="1" precursor="true">MIHVRRIAVLFLVLGFFCIGFSNQLNSVIPSMDAESVTVTLIFMNEVTDYNIQSNPSKTIYSLALDGVSGRDMNLPLRMGPVEGLWTRQDPKRLSVNVALLIPAIDEPQVTIRENIVTLRFFRSNIDVDIEKFTTYGMTLSTAMTYLFSEEMLDLSYIISPSVRDEEVVVGFSLAMPEDILRNILTSLGDRVAYSYLTDGTFYLGTPEEVQSLVNAFWKTYIGVEFKLEGETVSEQIERLRKTLPVNSFIEYLPNEASLMVFGDLQTHMSLSAALTTNTVTKEFTIPWEITDVEDTPLNSYLDLARKLNATLFSESLTIISIPEFNKLILSGNDSQVNALYEYLELYRENVTSEDLDSSKARKTITLPDNFFLIEDVLKLGSVGGSGLTEGNTLVGAILSILQSYAPYEEIAVDRAFEPIGKVTFELPNYLVPVLEKTVDSFSGISAEVSYTIVNYHLTIEESVRSQVERITGALIEPLGERKGYILKGSRSSIGTAEYLLSLFTGITFEDYSSTYLELKANDSFEEVSAFLRTFYSAQGLVQDEYTVEQIADRLVFMYAPSEIMEKAVLELEQHERQIYRVTKESILEIAPEIYSSGLGELLQTILVENETADFIQSAGLLVVSAYPERLAEIETIIEERIPRIKEMLENRMSSQENRLSLQIEAIPGWDIEKFRMYLNDFLGTELFSEITLTTSGSGYIVIAAESVLEAISAEAEKLRGFEEPSYRLETSIPSLAQFELLLQRLGIAVTIVPVDNQFMIVGSKVNVEEASRLVRQLSTGLPVQGEVSESETVYEYRFIDIPYSEVQGISDLLDKLNLSVEFVNTPSGVAIVATEDRLKEAMVVIDSILSRIETIETGPRSYSLIDIEPSLVDSLDEILSLLGYEIDLVESPAGVIGIGVEAQLAKAKKIVEEIMNKEASILPQQGDIESEKSYLIIFSKPEVEIASLNSMIDVFGMDLVITPIYDKIVVVGDSEDLKLFNGLYDQILTTESVEGAFVSREIAGVPGWDSERLLSYLGVVLGPEKTANISFVQTAKGYIISCPESIIERVENEFERLRGIESPSYSIESKMPQIDEINSLLSRLGIIVDILEVDDYFVVVGSEYNVARAKELISKLVEAIGEDPESKETVFELSTIESKDSQVFGEIFSSIGIDVRLLESPSGVLVVGREEEVSKAIETSKSILQKRPSTALAQAVFEFVPAAFEEIGDYSLILEKMGIDAELLPSPSGVIVVGSSEEVSKARTAVQTIHDQKQAFDSTEDSKNVSTFVRRVAGWSDEVFTSYLSDFLGEDLYSRVSIAPTVSGYIAVGPIDLLETIEAEVARLNEIQDPYFIVKQGLTPLDQLELLIEALGIRVEIIPVEDKYLIVGNHDSVVQTGELIDQLIDAIYPEGKPTEQTATSKTFIFLPIEPEDIAPLETVMEKLGIISEFVQISNGVIAVGSTEELSRSLDVVESVMAHSESVTAELEMDYRFVDVLKDSIDQLLPIIERLSIGVELLDTPAGVVAIGAEQDLDRAEELIKAINSRDTKEVPLQEKYESYLLLPLSAGITVESLQPALELLAYRVFAVSVADKLIAIGSEEDLLKFKALYMQLQSQEVDREERISLEIKMIPGWDLTRLNEYLRLFLGADEFERISIVSSSTGFVALTPRALADVVEAEISRLREFEDPAFTVIERVPPVDDLEGLLVRLGVLVDLVEMGSSTIVIGSGEDVRQTGIIIEQLMESVKFDVASPEVMEYSVLDIAQDDIESFSAILESLTIDVSLISSPSGAIAIGSHQAVARAETVVEDILSRRTTPQVYEPTYAFTGIQSADIAIYQTILDKLDSGVELLPSATGVIMIGEGDKVQEAVKTVNAILEREALFDESEGQPDRVSNVAAIVPGWNDEKYASYFADFLGKDDFSRITITPSSSGYIVVGPQEVVSKLVKEASRLAGIEDPFFVIENSLPAVEQMDSLLERLGLKVTILPVEDKFLVVGKKESVEEAVELIRLLSNGLEAPSSSRKYDFQIMPASEGAFDTIRQVLAELKIEATALSFGDNVILVGYDEDLESAAKVVNSINERTVTLETDKELKYSFTEIPNDRINEFSAILDSLEMDVQLLSSPSGVVLVGTEEESAKANDVILSVLSKAEEDEMVESRFFNNPAGWEDGKLVTYLRSFLGEKDWAKISVTPVQSGYLIVGPTAILDRIHSETVRLSGLEKPHYEIVDTVPSIQNLQGMLEKMGLAVTVVIVDGRSMVIGPEDDVIQTVRIFSELSEGVVLPKGEEPDVFNFVEIPTEEVESFRAIFSRLGIRVDLLNAPTGVIAVGQGEEVAKAVDTITSILSRREVQVVDGEKSYLVVEVADGFDLAAAQSILSAFNINVFPLSVAGKLVVIGSENEIMRFAEIREDIISEHRVTVIVPREVTLEELTGIVDTLEMEISVLEIRDSFVVYGKEGDIERVRAILSELVSEKPSEEVRHSRIFTGISLSTDFLNKLLSSMNSSLTIYGEGDKLVAVGTEDDIEMFEGLLKEIGSAPSTEELTAQFYPRIEGWTGETLSGFFEAMNLAVQVFHENSQGYLLIGPESELSKLPDIMEGLELKTKKLTTLYPVPSGMTFEELREILISAGFNLSYTKLGQSMSISGLEEDVELAVALLDEVIRSNLGKGISYRLIKLPADLTLEKFEKIMGDMALGISSVQVDGEVMLIGSDSDLRTANEIVEYLTPEGTPIEDEVVYSVIPISEELSMTEIAALVEKLSLNVEILPVGEDLFVIGTQRNVDSFRELVNSISATLGIEEVQSPEYTIVEFVEEISLDQFRELLASLNISVKIVEVGDYLVFIGSGEDNLEAAELFSRFETKDTEPESEEIEFEALSFPEGFDINSLTTVFEKLDLRVDINAVSNVLLIIGTRESIENAVTIIEKLVQVSTGDSGEGNVFKVLESKEGVSSELLSQLFRLIGVEVEILESETVFVFVGSEADVEMAVDVYDSLGESAGVDEGPLSYTITILPKNLTPSQLQTAFTSIQIPVGVIEAGDYAIIVGTKASLARAQELVSSLRIGIDASGTSADGSVSYITFALPEGTEINQFESIAGLMELKLKFEPVGERVFMIGTAQDIGEFEQVLSGLVSEKSGIVNEFRFVKKLSGVDAETLKTYLLAREIELSGVFDVSGGYLLIGSADSLDGAQSIIDYLLDNQQVHFAYIDLPASITPEILQAIANDLLLEISFAQITPTRYLFVGNMEDVESFRDILAKAVTEDTKFLSYSIVVVGQAFNDDLSRVYGPEGSQRSGMDDLKDALESIGVSVFIGKFDNRLLVVGESVHVDLARQLITELNQTTGSTEGTEKVRIEDLPPVSGWSIEQITQFLEAAEIQLRSIIEYSGRLIGIGTQVGLENAREALSILAVDSKRESVRVEKSLVSDNQLQEIISKLSLEVDYIDLDRQWLLIGDPESLMIITRTIEEAAADREISRYITDLTVNPQELADLLRESIEGITVQTFADLQMLLIKSKSSALLDAAEDMVRDVQESRKAIDPLEKGVVVKDSMVSIRVTDQDLEALLRTVSEKLGISLLFVDKIVENITMSIEDLSWDKLVKVINATKPVEIVRIDDIYAVTKKEQKAGEEPTDVELVYRVYHNVEELTRLIEFYGGEVLSDPVNGYIVVRGLAKSRVDNIFDEIGSALSQPKKQVRIETRLVDESLIDEIQREIKTSIGINAPEILIENGSVDLDFGIIDYLDITQLIDDLVNTGTVKIEADLSDRDNDSDLISSPSIVSMSGEEAKIHIGDTIPYLVRTIEYVEGNPVEIETIEYLNTGVELRITPTVNDDGKILLDLFIKVSEPEKYVDGTRTLYGEKTREANSRLIISDGNTLTIGGLVANKDTVTVNKMPFLSDLPFIGKLFTTENKTSDKRELVIFITAEVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J0</accession>
    <name>I2F3J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730547.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0779"/>
    <dbReference type="EnsemblBacteria" id="AFK06493">
        <property type="protein sequence ID" value="AFK06493"/>
        <property type="gene ID" value="Theba_0779"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0779"/>
    <dbReference type="eggNOG" id="ENOG5033E8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192806_0_0_0"/>
    <dbReference type="OrthoDB" id="1996008at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032587">
        <property type="entry name" value="DUF4911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16256">
        <property type="entry name" value="DUF4911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="80" mass="9214" checksum="D03DBD964504CEC8" modified="2012-07-11" version="1">MGEILEYDLFVKIRPEDIHVLCYIAEAEDNLMNIRHVTDEGLLKIIVPADLLEEVKSFLQSIKNRIELEVVEIRANPGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K9</accession>
    <name>I2F3K9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 12">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yidC</name>
        <name evidence="13" type="ORF">Theba_0798</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730564.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0798"/>
    <dbReference type="EnsemblBacteria" id="AFK06512">
        <property type="protein sequence ID" value="AFK06512"/>
        <property type="gene ID" value="Theba_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0798"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618011_0_0_0"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="448" mass="51333" checksum="05D8174829145942" modified="2012-07-11" version="1" precursor="true">MKRAIILTLIFVTLFTLSVSGKELTTQEGTSTLIVSGKTLKVTLDTKNGLVLGVTSYADNKTVEFYVYNESLGKDGFNVFDVEGTELLPTSFSYDKDEEGNVIVSFNYEQGSKSFIILNSPYYDFRVELNFNQKIEVALPFISYQNQTIGPDSSYYLTYDKFSGQKTLFAITAMQGTFKFQRYESETGRGILESFAGPMRLIHMRQALPEHYDAIVKDLQDFGGVTFFSWIYHGIVYFLFWLYQWSGNFGWALILFTIVTRFILYPLYHIQTKSMLMMRMLQPEVEKIKKKYKDPRKQQEAMMALYKEKGYNPASGCLPILLQLPVLILLYNAIRYFSEVMAYTPGFLIWKDLSVGNFVLNIPFIIITVVVGIFSSLLTAQDARSARSGVIMQVIFPILFATFPSGLLLYWTTQSVLQFFISWVVYKRNGIKGLTLRQMLGLQEKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q0</accession>
    <name>I2F3Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:ferredoxin oxidoreductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730594.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0839"/>
    <dbReference type="EnsemblBacteria" id="AFK06553">
        <property type="protein sequence ID" value="AFK06553"/>
        <property type="gene ID" value="Theba_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0839"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_0_0_0"/>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="203" mass="22295" checksum="F8E5B4DD798E61F4" modified="2012-07-11" version="1">MKQAFTQPHSVRISGIGGQGNVLMGIILAEALIIQGNWVVQTQSYGAQVRGGLSYCDVLFNSEPIDYPKAHSFELIYSMHQTAVNAHVPLLHVNGVLIVDSTLVSSIPKEGVRMTRKIIQKPVTELTEKKFGSTLPANMVGLGLIARAGSFVTTQSLKEAMTKHIKAKYVEMNAQAIDFGYSLIEKSYSIRRERIDSVGRGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U7</accession>
    <name>I2F3U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="10" type="ORF">Theba_0890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0890"/>
    <dbReference type="EnsemblBacteria" id="AFK06600">
        <property type="protein sequence ID" value="AFK06600"/>
        <property type="gene ID" value="Theba_0890"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0890"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="9">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="601"/>
            <end position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="820" mass="92406" checksum="FA32A162F232DDCB" modified="2012-07-11" version="1">MAEMTPMMKQYLEVKNNYKDCLVLFRLGDFYETFLDDAKLVSNELQIVLTSRNGVPMAGVPYHSINGYLKKLVDAGHKVAICEQTEDPALAKGLVKREVTRVVTPGTIVEDELLPEAENNYIIAIGKSGEFFIIVLADVSTGEVIISEAEDLISLKDFIVASQPSQVLLRESLKDLKKEIAGVTSSMVELIEDWHFALSSGINYVKEFYSIASIDHLELDDKQVEVLGALFKYLETINFSPLKHLSLPRILKKTDSMQLDASTVENLNLFRLERKGSLFEILDETTTGMGKRRLRQWLLSPLTDRHKIDERLDVVHALYSDRHLLDELREYFHSVYDIERITSRLSTDRITPRDLQSLRTSLTVLPYIKELISNETAFDRLRERLELFPSELELLRRSIVDEPSSSIGDGNVIRKGFDAQLDSLRDLLDNSVEKIRAIETSEKKSTGIPSLKVKFNKVFGYFLEVPKSQSGKVPESYTRKQTLVNSERYITPELKEFEDKILSANEKIQSLEKALFLCVCSQLMNSLQRLKDAAIVLSEIDALQSLSLVARKYNYCRPRFSVDGSARISNSRHPIVERFVPDFTPNDISMDSSENFFIVTGPNMSGKSTFIRQVALLSIMAQMGSFIPAKDAMLPIYDRVFTRIGARDELASGKSTFLVEMMETATILSKATEDSLVILDEVGRGTSTFDGISIAWAVSEFIYEAIGCHTIFATHFTELTELSSMYPGIKNKTARIVETEKGIIFLHKVINGVANSSHGIEVAKLAGVPETVLSRAKEILRVISKQSALDKAVRVLTAEDLREIRQSKKGKMNRNQISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V2</accession>
    <name>I2F3V2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_0895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492601.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0895"/>
    <dbReference type="EnsemblBacteria" id="AFK06605">
        <property type="protein sequence ID" value="AFK06605"/>
        <property type="gene ID" value="Theba_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0895"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_0"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="34677" checksum="F6122DCD9A0E888D" modified="2012-07-11" version="1">MDKQIGLSPMAGYTDAVMRELSAEWGADFVFSEMISVEGVLRASGRTEEIVPVTPTRIQLFGSSASRMAKAAMRLSEVATWIDINAGCPVKKVTRKGAGSALLRTPEKIAEMITALKNSIDVPVSVKIRLGNDATDTEKIIYQIIEAKPDAVFVHGRTVLQGYSGKANWDEIERITKLLHSEGILSFGSGDMFNPEAIAYALENYFIDGVLVARGAIGSPWIFKQAKDLIKFGSYEELAPHERLALFLRHFRRLSEAVGEDQAVRDLRKSFAGYTRNIRHAASLRTEYMKCNSFCEVKKLFEDLIPDYKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W6</accession>
    <name>I2F3W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0910"/>
    <dbReference type="EnsemblBacteria" id="AFK06619">
        <property type="protein sequence ID" value="AFK06619"/>
        <property type="gene ID" value="Theba_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0910"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="206" mass="22728" checksum="834E444D0B8B03A6" modified="2012-07-11" version="1" precursor="true">MTLQITFLTLGLGLVLALPISFGQVYGNKWIKALIAGYEKILRSIPELVILFLIFYGFPKIGIRFSPFAAVIIGLGFRSSAYQSQIFRGAINSVSSAQMRAARSLGMTNLKGFINIVLPQAIRIALPPWTNEFTIVLKDSSLAYALGVTELLRQGGYIIATKYEPMLIYLTVAVMYFIVTIAINKTLGSVEKRLAIPGFDVKETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F415</accession>
    <name>I2F415_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730689.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0962"/>
    <dbReference type="EnsemblBacteria" id="AFK06668">
        <property type="protein sequence ID" value="AFK06668"/>
        <property type="gene ID" value="Theba_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0962"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_0"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="47"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="244" mass="26689" checksum="0967BB6751888EE0" modified="2012-07-11" version="1" precursor="true">MSRAMSKITLGIIVAGLLWFSYSSVSAVYPFNWSTLTKYYKLFLDGIMTTLQLSVIALALAVIVGIAVALARDSKVNLFRDAGTLYVWFFRNMPLLVVILLVYYGFGSAVNVDRFWAGVISLSLFEGAYVGEIFRAGIDAVPSGEKEAGEAMGLYRSQIMFSIVFPQAFRISIPPLIGQLVTLIKDSSLVSVIALGDLTMKARQVGTQTLAVFEAYIVLAACYLVMTSLVSLVGRILERRLAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F435</accession>
    <name>I2F435_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="18" type="ORF">Theba_0982</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0982"/>
    <dbReference type="EnsemblBacteria" id="AFK06688">
        <property type="protein sequence ID" value="AFK06688"/>
        <property type="gene ID" value="Theba_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0982"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="428"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFK06688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="668" mass="76819" checksum="A8D08CCC8C00147F" modified="2012-07-11" version="1">MLFEMDSSYSPQGDQPQAIEKLIDGLKSGDRFQTLLGVTGSGKTFTMANVISTLQRPAIVISPNKTLVAQLYREFKTFFPKNKVELFISYYDYYMPESYIPSKDLFIEKEAEINETLERMRISALKSVLTRNDTVVLASVSAIYASGDPKDFATMNIFLERGKSINRKELALKLANIQYNRSEDVSAGGVFHVKGEIFEIFPPYEDFGIRLYFFDDEIERIVSFDPINRKTIEELDMVTVYPAKEFVTTQDKILGAMRNIENELEERVKQLEREGKYLEAQRLRQRTTYDMEMLSSVGYCSGIENYSRFFDGRMPGEKPYTLLDYFDREKFITFIDESHIGVPQLGAMYRGDYSRKKNLVDYGFRLPAAFDNRPLKFEEFLSTVGQIVFVSATPGNFEAEHSTRIIDQVIRPTGLVDPEVIVHPTESQVDDFIERMREVKKRNERALVTVLTKKAAEMLSDYLNEVGIRSEYLHSELDAIERVEVLRKLRDGTVEVVVGVNLLREGLDLPEVSLVAIMDADKEGFLRSETTLIQTIGRAARNVNGQVILYADTMTGSMKRAIDETNRRRLKQLIYNKEHNITPESIVKPLYRNIFEEFAGENLDKEREDKARATYLEGVMALKESLDYEDYIALLNEEMIRAAGELRFEDAAILRDEMYSLKKSKQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F447</accession>
    <name>I2F447_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0994"/>
    <dbReference type="EnsemblBacteria" id="AFK06700">
        <property type="protein sequence ID" value="AFK06700"/>
        <property type="gene ID" value="Theba_0994"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1158117at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="458" mass="52441" checksum="1061D405F63B8086" modified="2012-07-11" version="1">MAFEIRGVVEGFYGKPWTMDIRREVIQYLGDHGFNTYIYAPKDDELHRKRWREQYDENFFKEFSILVQEAESRGISIVFAVSPGLNITYSSNSDVSAMVEKLMRLADAGVRSFGLFYDDIPETLIYEKDRNTFSSLSSAQAYFTNSVFKSINEKLKTLSRFMICPTQYCGREATEYMKTLGTELDRNISILWTGPDVCSNVLSADNAELAENAFQRKILLWDNYPVNDASMVPELHVGPYEGRDPNIVNHAEGIVLNPMIQPLASKIAIFSASEFLLDPYRYDSDLSWRRAISEIAPGCEEEMIHFCEYNLRSPVHTTHSERLTGLTSNLSKLLSKNRWTEVYEILLDEATKISGSEKALNERLSADLIREIEPWIFEFSLWGDALTKTTGILAMRDLMFSSSVSYEELSETTKLCREIEISLCKLVKTETLTSGILFREIVQEILVRTKGYLKLIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F465</accession>
    <name>I2F465_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730729.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1013"/>
    <dbReference type="EnsemblBacteria" id="AFK06718">
        <property type="protein sequence ID" value="AFK06718"/>
        <property type="gene ID" value="Theba_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1013"/>
    <dbReference type="eggNOG" id="COG4120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067296_0_0_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="337" mass="35417" checksum="BB9305C8FA2D8BB4" modified="2012-07-11" version="1">MAILEQGLIIGLMALGVYISFRIVDLPDLTTDGSFALGAAVAVKALVSGLPAWIAIMLAALTGAIAGSITGTIHRKLKINVLLAGILVMTMLYSVNLRVMGGPNLPVPRVVPEGTTQSFEEMSGGTGLDNLFEELEINTEKRQSRTTVVAKNIFNNQLDGSDLLLIVVLISAVVVVLSVALKSDPGMTLRAFGSNPSGVVSFGISQDVLAIAGLTIANCVIGLSGGLFALYSGFSDATIGQGMVVTGLASVIMGEILLGRVKLFYGLLSPIVGGVIYQALLSLAMRYGYRIGFLASDMKLLTAVFIITVIGLRQLSSSGGKRKVKQEVKRLWSNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F474</accession>
    <name>I2F474_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730737.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1022"/>
    <dbReference type="EnsemblBacteria" id="AFK06727">
        <property type="protein sequence ID" value="AFK06727"/>
        <property type="gene ID" value="Theba_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1022"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_751642_0_0_0"/>
    <dbReference type="OrthoDB" id="1280784at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="34"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="37125" checksum="FEDBE73F0A1188AF" modified="2012-07-11" version="1" precursor="true">MRHVRRSVMLLVILAIVLGGEALLAGLTYGYVTPGPDTWYRKDVEGFEYAASLVGAQVVVLNSDYDTEKEITNINTLINMGVDGMCVFSFNPNGAFIAAREAARAGIPLVVTDNVGQVLQSDDDIVACIDFDWEGMGVNIANYIAENYPGENIACIMGLFEHVPVQMFRNTFEPKVKELGKNEIVAIRDGQYTPTVAVDQAQDLIESGYEFSNLFIFNEEMAAAVVRMLKTRGLLNNPIRVITTNGAPYGIELIKEGSIDYSISTSPGWEGFVSFLALHAYTQGVITDLNQQILLPNTPITPETIDDKTKVVPWDIDPVWIDLTREYFPQYNSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F487</accession>
    <name>I2F487_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730748.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1035"/>
    <dbReference type="EnsemblBacteria" id="AFK06740">
        <property type="protein sequence ID" value="AFK06740"/>
        <property type="gene ID" value="Theba_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1035"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_0"/>
    <dbReference type="OrthoDB" id="1771824at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="121"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="233" mass="26454" checksum="1ED2432C7DE2D768" modified="2012-07-11" version="1">MISKVGLERIGNLRIEILRMARYVQSIFNKTMVAVLERNEHQARDVIYSDSVIDYHQVELQAMIIGLTGILTPTGKELRLLTLSMNIVSALERIGDKCVFICETSLSLSKRPPIGYYDKMKSMFESVSIMTKGAIDNLVEPSLSEAERLCKSDDAIDRMQEEVKSDLIRYCEQSPSVVGRAFDLMMIFCALEEIADLSTELMEAAVYIETGRHYRCVNDDFKPVDFETQNEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F489</accession>
    <name>I2F489_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB</name>
        <name evidence="8" type="ORF">Theba_1037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492778.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1037"/>
    <dbReference type="EnsemblBacteria" id="AFK06742">
        <property type="protein sequence ID" value="AFK06742"/>
        <property type="gene ID" value="Theba_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1037"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_0"/>
    <dbReference type="OrthoDB" id="874197at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="52"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="349" mass="38980" checksum="2797DAC98C3CA15D" modified="2012-07-11" version="1">MREERFLTPGEVQEDNSIKSLRPKTLQEYIGQNQIRQRLRVAIEAAKVRREALDHTLLAGPPGLGKTTLAHIIANELGSEIYVTSGPVIEKQGDLAAILTGLERDDVLFIDEIHRLNRSVEEILYSAMEDFQLDIMIGKGPSARSIRLDLNPFTLVGATTRSGFIGAPLRNRFGMILEMEFYPDRDLKQIILRSATLLGTSIRDDAALLLARRSRGTPRIANRLLRRVRDIVTVEGESEITMETVESAMTLLSIDSEGLDSMDKKLLSILIESYNGGPAGVKAIAASLGIEPETISEVYEPFLLQSGFLVRTSRGRMVTEKAYRHLGLPLEGRNTPLWNYADHREEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C8</accession>
    <name>I2F4C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoacid:acceptor oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730779.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1076"/>
    <dbReference type="EnsemblBacteria" id="AFK06781">
        <property type="protein sequence ID" value="AFK06781"/>
        <property type="gene ID" value="Theba_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1076"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_0"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="204"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="556" mass="61365" checksum="259266F6433BE89C" modified="2012-07-11" version="1">MKDYVIALSGEAGQGLNTIGDMLALSLFRNGYCIFTDKSYHSRIRGGEYVYRIRVSDSPLYSMRQEFDLIVSLSKSTTISQLQYFHDGTTLIYDSDSNHVNSKDFDFEVKALNFPFRSIAKDAGEPRAQNVVALGGILGLFKVKREIPSKLIEETFSGKEEIIKANLEALKRGYDLSLSIEIPPLDVQEHNYYLMNGTEGTGLGAIAAGCKFLAAYPMTPGTGVMTFLASNAERHRIVVEQAEDEIAAVNMVIGGAFAGARSLVTTSGGGFALMQEGVSLAAMTETPLVMVDAQRPAPATGLPTRTAQEDLLFVVNAGHGEFPKYVVSPRTPKETFELTEKAFYIADKYQIPSIILLTESLVDSSATIEAPIHKEEFLQRFITEGNEEYRRYEITENGISPRAIPGGKATVRVDSDEHDEAGYITEDLEIRSKMVDKRMKKMEGLLGELSAPAKFNLDAPLVLVGWGDSWGAIDEFAMSRKDVGYVHYSEVFPIDQSIREELEGKKLCSIEGNYTGQFATLLRSVTGLQIDHVGRYDGRPISANWIEKSLKKEGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D8</accession>
    <name>I2F4D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730789.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1086"/>
    <dbReference type="EnsemblBacteria" id="AFK06791">
        <property type="protein sequence ID" value="AFK06791"/>
        <property type="gene ID" value="Theba_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1086"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_1_0_0"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="169"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="393" mass="42758" checksum="94DE314C3CDE0599" modified="2012-07-11" version="1">MDKKREIIHTVDKIASDVIELGKKIFGFSELSYEEYKSSEALKSFLKASGFEVVSPAIEELPTSFIASYGNSGPKIALMAEYDALPEIGHACGHNLICTTSIAAAIALKESGAIEETGGSIVVVGCPAEERGGAKRVLVEKGVFDDMSAALIIHPASMSTGFDISYALKTFSIKYFGKPAHAAADPAKGVNALDAVIQMFNGISALRQQLPEKVRIHGIITNGGQSFNTIPDYTAAEIGIRALSIEEVDVVSEKFRKIVQAGALATGCDFELKQTEQMEEVYVNVPIARLLDSNFELVGEKTTMRTYEQGVGSTDVGSVTHVLPAIQGYIDITEHRDIPTHTREFASCANSEYGYNAMIRAAKAMALTVYDLLSDRSLLEEVTDYFRERRKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G9</accession>
    <name>I2F4G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1117"/>
    <dbReference type="EnsemblBacteria" id="AFK06822">
        <property type="protein sequence ID" value="AFK06822"/>
        <property type="gene ID" value="Theba_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1117"/>
    <dbReference type="eggNOG" id="ENOG50337Y9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106275_1_0_0"/>
    <dbReference type="OrthoDB" id="1834457at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="24511" checksum="22E97A0230F892C6" modified="2012-07-11" version="1">MLRTGRLSSQTVNLLDTLQNKLPNFYLAGDTALAMHYEHRVSFDLDFFSAESYRPEVLLEYLKQFGVSVENVRIQTGNLEAEIEGVRASSFEYHYALVEPLEKYKSLDVASVIDIAAMKLSAIAARAEKKDYFDLAEILKREPSKKVLQAFIKKYGREVDLYHIIRAVTFFDDVEASPDPFGAVLTWKEVKEFLEAKNKELFDVAKTLVRLDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H4</accession>
    <name>I2F4H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06827">
        <property type="protein sequence ID" value="AFK06827"/>
        <property type="gene ID" value="Theba_1123"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1123"/>
    <dbReference type="eggNOG" id="ENOG50337GF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140079_0_0_0"/>
    <dbReference type="OrthoDB" id="2049035at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045397">
        <property type="entry name" value="DUF6516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20126">
        <property type="entry name" value="DUF6516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="130" mass="15668" checksum="F8C056D3F5D869BF" modified="2012-07-11" version="1">MQKILKFVEKSLLVKDFKVHDFKTGKEFAYIKLEILFKDSSKVHLREFVSSTQRKYSFHWIVDTRIEIRWDNSPHHKSITTYPHHVHVNQDVYPSECSDPVKILRWIESLLISKEELTPEIILHEIRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H9</accession>
    <name>I2F4H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730826.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06832">
        <property type="protein sequence ID" value="AFK06832"/>
        <property type="gene ID" value="Theba_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1128"/>
    <dbReference type="eggNOG" id="ENOG5033HZ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1466577_0_0_0"/>
    <dbReference type="OrthoDB" id="1835751at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="184" mass="21137" checksum="C8C9B20E2AD4F18C" modified="2012-07-11" version="1" precursor="true">MRRLLTVCFLALSIGLFARFEIGLPVFSMPQSDSKNGIVEVLTDLSEENMNLEITVVFTDEDYPCPVINFLYDIYRYFKYGRIEDIESFYIRFDSDGKIIALDFPGVFAADHAFDDTKNLHGSAVLMPDVITFVDGRPLIFINTWNHMFGVIPSFDRANETLLSDYPVTEGTRSDAEHKYSWHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J2</accession>
    <name>I2F4J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative toxin-antitoxin system toxin component, PIN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730836.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1143"/>
    <dbReference type="EnsemblBacteria" id="AFK06845">
        <property type="protein sequence ID" value="AFK06845"/>
        <property type="gene ID" value="Theba_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1143"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_6_0_0"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="132" mass="14828" checksum="318B8D85F15CCA1E" modified="2012-07-11" version="1">MRIVLDTNVLVSALINPYGKPAAVLNAILSRFVVPCYDARIIDEYERVLRRPRFQFSNDDIRSLLDFFLREGSFGSPEPVSIKLPDLSDLPFVEVARASGAPIVTGNAKHFPENLARVMSPAMLVDVIHKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J9</accession>
    <name>I2F4J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730843.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1153"/>
    <dbReference type="EnsemblBacteria" id="AFK06852">
        <property type="protein sequence ID" value="AFK06852"/>
        <property type="gene ID" value="Theba_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1153"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089333_1_2_0"/>
    <dbReference type="OrthoDB" id="1200118at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="22702" checksum="50C6EEAF3A574B9D" modified="2012-07-11" version="1">MNEFEKIKQIAAENNGFVETCDVVAEGIRKEELRRLLELGQLEKVSRGVYVLSERLIDEYKILQMRCKSCVFSHTTSLYLLGLSDRAPSKYHITVPQGSNVTHLSKERSDLVFHYVKRSLFNLGLASVKSPFGNTLRSYDSERTICDLLKEKDRFDIQIVTDALKSYFGSTRDIAKLARYSRVLGVEDLLHTYTEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K0</accession>
    <name>I2F4K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06853">
        <property type="protein sequence ID" value="AFK06853"/>
        <property type="gene ID" value="Theba_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1154"/>
    <dbReference type="HOGENOM" id="CLU_3081642_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="52" mass="6039" checksum="9710A28B55D828CB" modified="2012-07-11" version="1">MPFDMMRRKSPSDTMPEKNFSLQEVMLLCGKPARPTVMGPPAKNRWPLARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M7</accession>
    <name>I2F4M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730869.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1182"/>
    <dbReference type="EnsemblBacteria" id="AFK06880">
        <property type="protein sequence ID" value="AFK06880"/>
        <property type="gene ID" value="Theba_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1182"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_9_0_0"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="243" mass="25830" checksum="2CA92D6FE035187D" modified="2012-07-11" version="1">MPNIEKGINVIIEDGAKIGDNCVIGHNVVIHRGVIIGDDVTIGDNTVLGKEPFAASTSATTSIEELKPLSLGSGTTIGASCVIYKGASLGEKCFVGDLATIREKTTIGEKTIVGKGATVENGTSVGKRVKIETGAYITAFSTIEDYCFIAPEVTFTNDNYLGRTEERKKHFKGPTLRKGARIGANATLLPGVTVGEDALVAAGSVVTKDLAPRKIYAGIPAKFIRDVPQEQLIEEQAFYEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q4</accession>
    <name>I2F4Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="6" type="ORF">Theba_1210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730894.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1210"/>
    <dbReference type="EnsemblBacteria" id="AFK06907">
        <property type="protein sequence ID" value="AFK06907"/>
        <property type="gene ID" value="Theba_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1210"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_0_1_0"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="79"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="88"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="179"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="297" mass="32784" checksum="25F40937EB098123" modified="2012-07-11" version="1">MIGEVTNVQKGMIEVRSESGEFFRCLLRGKLLQKERTEKNVVAVGDRVLFERLHKDQGIITEVLPRDKCLVRKGAGKKGRHLHQVIAANVDQVLIVVAIKDPPYHKNLIERYITAARGSDLDVTIVFNKADLGLSEETKADIQKYRDLGYRVFLTSTVSNLGIEEVKSALQGRSSVLAGSSGVGKSSLVNAICNSNVRTGEVSDSTHKGKHTTTSSQVHLLPDEGRIIDVPGMREFAISGTEGLDEAFEDIVELSAKCRFRNCTHTVEPGCAVRQAVANGILDERRLQNYLRMKTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R0</accession>
    <name>I2F4R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730900.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06913">
        <property type="protein sequence ID" value="AFK06913"/>
        <property type="gene ID" value="Theba_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1219"/>
    <dbReference type="HOGENOM" id="CLU_796466_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="39599" checksum="D1FF7B8B5464E909" modified="2012-07-11" version="1">MVNFVLDKGRGAELLLSLFRLNNHEKLTPNDGESLEALSDWVFKARLSLTEETLTSLARLFSWEAFFGLKIIPYFFLEGSPTPSGLLKMIERISPERLLSMFLSNDFMPLEKKNDVFLKSLEENEKGALEYVSSIPWLLSSDRYEAFQMLMDQAKTHESFLELLRFAEKEIASMVELENLVNYGEEILLKNTERFEGWFLPFLLDIEPSSLSDKMIRLHVSAFLGGSVITVEVPEKNSVISLIGVDRVRKRSLSYEKRSAAGVISELSDQNSLRILKIVMRSRQCIDEIAFSSGVHRHEVIEVLAALCRQGLVIPEIHEKELTFTSEERLIDSALEEVRKGIMEGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R6</accession>
    <name>I2F4R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730905.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1225"/>
    <dbReference type="EnsemblBacteria" id="AFK06919">
        <property type="protein sequence ID" value="AFK06919"/>
        <property type="gene ID" value="Theba_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1225"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="306" mass="34314" checksum="B97CFCF718D153E3" modified="2012-07-11" version="1">MNGIVTSNLVKRYGTFEALKSVSLSIEEGDLYCLLGPNGAGKSTLIRILTGLMKPTSGEVNVAGLDMKRDLKKIREKVGLVSERVILYDRLTPVENLLFFASMLRIERRVALKKIESLLDKVDMIEWKDKPIRVFSTGMKQRVNFVRALLHEPSILFMDEPTLGLDPHSTRTIRNMVRELNESGRTVVLTTHIMSEAENIAKSVGIMNKGKLITTGKLEDIRASLNRDRLIITVKGRPEVPIESIDGYMSASRLDGVVKIDFRPGISMESVLPRILQMKLKVIDVDHIKPSLEDVFVELTGEKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V7</accession>
    <name>I2F4V7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486619.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1272"/>
    <dbReference type="EnsemblBacteria" id="AFK06960">
        <property type="protein sequence ID" value="AFK06960"/>
        <property type="gene ID" value="Theba_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1272"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_0"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="408" mass="44920" checksum="8753A86906E7070E" modified="2012-07-11" version="1">MKAAILLTGDEITKGVVKDSNGGYLSEKLTALGFEVQSIVIVPDRKEFIEREISNALDRADLLLITGGLGSTFDDITLQTVADFLGKELIYDSEYHSSLSESFEERYARKAPAGLKRQSFVIQDSIQLANPSGSARGAYIREDNKEIVILPGPPVEMEAVFREALKFITLPPPSYSRTIGFVDLTEPEVEEFTEQMLTEFPSVKFVTRVRYFSGPTVILTSDNESILEEICSLFTRRWKKYVYTTTGEELVQVVVKELKARKLSVSVAESCSGGRLSALLTSVPGVSDVFPGAIVSYSNDIKISLLKVNEDTLNRHGAVSEEVAAEMAAGTKILFGTDIGLSVTGIAGPTGGTETKPVGMVCSAVRIGDLTKTYTDMFRGDRETIQLRGASTVLKRLWRLFWNEFYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V8</accession>
    <name>I2F4V8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ORF">Theba_1273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730939.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1273"/>
    <dbReference type="EnsemblBacteria" id="AFK06961">
        <property type="protein sequence ID" value="AFK06961"/>
        <property type="gene ID" value="Theba_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1273"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_4_0"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="486"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="663"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1012" mass="115403" checksum="933515213448BC17" modified="2012-07-11" version="1">MERVLYRVNEPISWVEKGNYNASRNLIIFPSERMLESFIEIHEKREGDGFFFSHDVFPFEEIGTSSRIRSERLALLRKLLLGELRTVYTSFHGILRKTVPIEVFEELSFKVEVGGPMTITESQLQSLGYSRSFSVTIPGEFAIRGGIVDVFIPGSEMPVRIDTFDREIESIRSFDPVSQKSLQRLNEVLITPAAEGITASPFRETALKRIRAAEQATGVSDEILLDRLDTMDTTAGIFYERQSILLDFLEGYNVIFVKPDDAIVEYGRRERETLELLSEKAVRKFLYIRYGGVSSEVLMKLKEYSIVSDGDVSSLDYDEELTEELQIIKRPRREEEYLPRIPVVDWTELEEGDYVVHKEYGIGRYLGVRTVENILGTREYLLLEYRDGNKIYVPVDRVDRVHKYIGSTEGIQLNSLRGTAWTRQKSKVNKEVKALISDLSNLYGSREVTSGVPLTGDSEMEKGFRDSFPYVETEDQQKAVEEVMEDLQSTKPMDRLISGDAGYGKTEVALRAAFRTVVSGKQVAVLVPTTVLARQHYENFERRLNPFGIRVEILDRYRTDVQRNKLLKKLKKGEVDVVVGTHSLLSKEVGFADLGLVVVDEEQLFGVLQKEHFKKLRLQVNVLSMSATPIPRTLYMSLSGLRDLSIISTPPAGRTSPEIYVGQINDRLIRTAVLRETNRGGQTIFVHNRVTELQELLSRLRDLLPEVKIDVAHGQMNKSAFERTIRDFYLGELDMLLCTTIIESGVDVPNANTLIVDDSHRYGLAQLYQLRGRVGRSNRRAFSYFLYDPKRLSDPSRERLKALKEFSGAGSGMKIAMRDLEIRGFGTLLGAEQHGNINSVGLYLYREMVEKAMRELHGEEEIGVEERTVDTELKNIPFDMVIPEEYVSDSIERLKIYRRIAACKAQDEIDEIESELLDRFGRLPSQVNSLLEASRVRLGAFNIGIKIVEYDPHSESIVMLHGENHIRDSLGIKGRRLVVNEREGKSILYGVPERHLMRTLKSLFLGAERNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W3</accession>
    <name>I2F4W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1278"/>
    <dbReference type="EnsemblBacteria" id="AFK06966">
        <property type="protein sequence ID" value="AFK06966"/>
        <property type="gene ID" value="Theba_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1278"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_0"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="25683" checksum="9F2F6E87EC5CB3C0" modified="2012-07-11" version="1">MYFFDLDHTILDFERSEVESLLELFKARDIDLSEEQVRSYQSINSKWWGYLEKGTRNKEEVVVGRFREYCDSIDVSFDPEELNDEYLTRLSRKAYFLPGAREFLTTLRRQGKRMAIITNGVYRVQHNRFLSAGLPEFFEFSLSSEEAGVAKPDPGIFHEAIRRAGVQRNEVVYIGDSLESDYRGAENAGIDFIWFGKHVRRNKGPVNIARNYDELLMLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W6</accession>
    <name>I2F4W6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Theba_1281</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730945.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1281"/>
    <dbReference type="EnsemblBacteria" id="AFK06969">
        <property type="protein sequence ID" value="AFK06969"/>
        <property type="gene ID" value="Theba_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1281"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631244_0_0_0"/>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GIDE" evidence="15">
        <location>
            <begin position="86"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK06969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="423" mass="48218" checksum="425D246E1449CC1E" modified="2012-07-11" version="1" precursor="true">MDYSSIVRLIGVGLSLLMLLFSFRSYRRKRLIDDMPTSKAHGVFIGLVEVSGKVECQNPITSYLTESTCVQYSWEISEHWSKTTTETYTDSKGKTRTRTKRESGWKTVASGESMCPFDLRDETGTIQIRPEKAKIEGVRAMDLRCRSSDPLYYGKGPAESIIHSDHLRMFTESIIPLDARVYVIGQSREREDIVAPEIAHDESSPLFLISTREEERISKSYSLNYWLLSLGGLGVSLISFFIASRIGFYRWIPSGVSDYFMPTGIYLGLWLIGWFWTTFNSLKSLRERVRQGFSQLEVQLKRRHDLIPRLSSAVSSLMKHEQSIQTKIAALRSEAAVNAKAAKRLLVLVEDYPELKSSEAVSRLQRELSDTENRLELARAYYNNIATFYNTRLERIPDNVVATLARLKNCELLLQSEGDGDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y5</accession>
    <name>I2F4Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06988">
        <property type="protein sequence ID" value="AFK06988"/>
        <property type="gene ID" value="Theba_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1300"/>
    <dbReference type="HOGENOM" id="CLU_2650249_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="76" mass="8590" checksum="62AF62259F5DA7D6" modified="2012-07-11" version="1">MHGITRKGILELEEENKPEKEGIMRALLSKIMESTSADRSIFINIDALAGKMNMMRYETFDALNFLHGRGSSEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z7</accession>
    <name>I2F4Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1312"/>
    <dbReference type="EnsemblBacteria" id="AFK07000">
        <property type="protein sequence ID" value="AFK07000"/>
        <property type="gene ID" value="Theba_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1312"/>
    <dbReference type="HOGENOM" id="CLU_2302544_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="100" mass="11410" checksum="0A798B55EE2CAE32" modified="2012-07-11" version="1" precursor="true">MIVSMSLLVAYNRLSNATQTAVAKENIRRLLAEFVEHKNDPVTQNDLDKALEDAEYSEYEIKLFSRTESQELSDLVVYRIEFGIVNSSGGDELYVSKYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F523</accession>
    <name>I2F523_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486750.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1338"/>
    <dbReference type="EnsemblBacteria" id="AFK07026">
        <property type="protein sequence ID" value="AFK07026"/>
        <property type="gene ID" value="Theba_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1338"/>
    <dbReference type="eggNOG" id="ENOG5033A2E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064046_0_0_0"/>
    <dbReference type="OrthoDB" id="733534at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="271" mass="31357" checksum="C1D203E5F1B68C8C" modified="2012-07-11" version="1">MPGFWTHIMYGKDVLEEIGLDLEADKREEFNLGCLFTDPGLYCSKDDPEFSLWRFSHTIRCDEFAIALCERAGGISRFYTLGVICHYFLDATVNHYIVARAGNGYKYRQLETMIDKVILKDRIEADILDLDPKAEFSGSLPAALEDLYRDISLEFYGLKGYSFQRAVESMNNYFEGLYGRSRLALILKRFSIREGSPEEAFFEDTHPDPLNLAMKPWFHSFAGWESKKTFHELYKEAFDNAVHFLQNYLDGVGDFSLPRVSLMTNLPLMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F524</accession>
    <name>I2F524_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase, GlgD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486752.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1339"/>
    <dbReference type="EnsemblBacteria" id="AFK07027">
        <property type="protein sequence ID" value="AFK07027"/>
        <property type="gene ID" value="Theba_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1339"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_0_0"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="41935" checksum="232054AD5B590D50" modified="2012-07-11" version="1" precursor="true">MKVLGIILAGGRGEYLTPLTQVRASAALPVYGKYRSIDFTLSNMVNAGISKVGIITQYSPRSLMDHIGSGKEWDLDRKQGGLFILQPYYSPDNPSMGYKGTADALFQNINILRRGNEDSVLIGSGDHIFKTDLAKIFRYHLDTAADITVLTGNKEGECGMEGMDRVVCRNGRVVKWIEKEKIAENPQEGDCVALDIYFINKFLLRELLYSAVPNGENELVKGIISPNLSSLNVREYRYNGYWRDIKLSKKCYFRTNLDILNPEIRRELFYENGRVFTKLKDLPPPKITGTAYMNNSVIADGCVIGGRIEDSVLFRDTRVMAGATVKNSVLLEGCLVEEGAYIENVIMDKYCTVRLGRSFVGEAEDPTVIEKHGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F537</accession>
    <name>I2F537_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="12" type="ORF">Theba_1352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730988.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1352"/>
    <dbReference type="EnsemblBacteria" id="AFK07040">
        <property type="protein sequence ID" value="AFK07040"/>
        <property type="gene ID" value="Theba_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1352"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_0"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="142"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="315" mass="34111" checksum="BB5F5BDDA03AF442" modified="2012-07-11" version="1" precursor="true">MKVTIVGAGMVGSSIAYASMIKGVAREIALVDINRELAKGQAMDLSHGNAYVRPMRIHGGDYDVSSDSDVVVITAGRPQKGGESRLQLLKDNARIVKEAVAKSLSYSKEPVFIIVTNPVDVLTWVAWKASGLPRNRIVGSGTTLDTARLRQSIADHCQLDPRNVHAYVLGEHGDSEIVNWSHADIAGIPLTDFCRNCRRDCEADLFQKLFEETKNAAYKIIEKKGSTFYGIGLAVSKVLSTIFNNQHSVLTVSSVHPEFEGLKDVPFSVPTILGREGVERILKVGLSSAELKGLSNSAGIIANAIKNLRDEEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F551</accession>
    <name>I2F551_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731000.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1366"/>
    <dbReference type="EnsemblBacteria" id="AFK07054">
        <property type="protein sequence ID" value="AFK07054"/>
        <property type="gene ID" value="Theba_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1366"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_0"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="26848" checksum="83C37AA1523E2A65" modified="2012-07-11" version="1">MRNEMIDLIRYLKKLGYLKDPRIEAAMMELDRADFVSSEVRDRAYEDIALLSFGSSGKVCSTSTQPSLLVTMIEELGMRDEDRVLDLGTGTGFCACILGKMAKKGSVITVEKDREVASVASRNFERYRMKNVRLVIGDGRYGYESDAPYDKIISTVALSGMSEVLFSQMKIGGRCVSPIYRSYMDTPVFLFERTDDTTLKVSEITGAVFMVAEESEPDPIYHNREFSLRLTDGRFQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F592</accession>
    <name>I2F592_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731040.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1407"/>
    <dbReference type="EnsemblBacteria" id="AFK07095">
        <property type="protein sequence ID" value="AFK07095"/>
        <property type="gene ID" value="Theba_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1407"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="248" mass="26765" checksum="F34811D0FF8578DA" modified="2012-07-11" version="1">MRMEGKVVIITGGASGLGKAAVEKFAREGAIVYACDMDVEGLDNLKKEFSELPGKVIPKRLNVTDRPAITELIGEIKSEFGRIDGLINNAGVTRDALIQRMSEEDWDLVINVNLKGVFNMTQAVAPVMIDQGYGSIVNTSSIVGVYGNIGQSNYSASKGGVIAMTKTWAKELTRKGAKIRVNAVAPGFIKTPMTEKMPEKILVALEEKIPLKRIGLPEEIANVYFFLISDESSYLTGQVIGVDGGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B0</accession>
    <name>I2F5B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731058.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1427"/>
    <dbReference type="EnsemblBacteria" id="AFK07113">
        <property type="protein sequence ID" value="AFK07113"/>
        <property type="gene ID" value="Theba_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1427"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930026_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="33307" checksum="1B2B07039B07C422" modified="2012-07-11" version="1" precursor="true">MNLTMSCFMCSRRRGFSVIEMLIVLAVLAGLIAVIAPIGVNTLRKSQAVSVAKDLKTLSSVFSSKIYLDGGVPVVIGELGRNVDGRSFGAAWKKNDDGEYNYFVFTNRSVDFETVSDVLVDSRQGIPFGIDDFTFLDGGLGRESLDSETIYYSLLGENFIAPLTEFGSTFNEISEGLKTLIQEFFVNNGRYPRDWIDKESGKDYRFEDLSLDASFWANSAFGGVVYKPAGKLLRVSPDKGYKFVFNFLGSSEKGELTERLKWDLIYNIGNDSADTGCWYFHSLEGRKIDISTLEIVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C8</accession>
    <name>I2F5C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_1445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731072.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1445"/>
    <dbReference type="EnsemblBacteria" id="AFK07131">
        <property type="protein sequence ID" value="AFK07131"/>
        <property type="gene ID" value="Theba_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1445"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_0"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="43"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="211"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="324"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="510"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="576" mass="64644" checksum="D59CECF3A39F7CA3" modified="2012-07-11" version="1">MDYRDRYRKWLESPAIDESTRGELISIKDDETEIKDRFYKELEFGTAGLRGKLGAGDNRMNKYTVSRATQGLANFILSGDPAYREKGVVIARDSRHMSKEFAEISAAVLAGNGIKVYIFDDIRPTPLLSFSVLQLSTVAGIMITASHNPKEYNGYKLYWDDGAQVLPEIADEVYTQMRKTELFVGSKTIPLEMARKKGLLVEVGKELDDLYISKVLSLTLRDSEDELDKSIRIVYTPLNGTGNIPVRRVLDERGFENVFVVREQEWPDPDFTTVGYPNPEDIKAFALAKRLGLEKDAHILLATDPDADRLAVMVRDDDDYVALNGNQTGALLVNYLLLSMSEKGLLPENGFIVKSIVTGDMAKVIAEGFGVRTYEALTGFKNICGKALDIEERGEGRFIFGYEESIGYVAGNFVRDKDAVSTSMLLCEMAAYYLKAGKSLLDVLEELFAKYGVFSEKQISIVLEGVSGQKRVERIMKEYRKSYPSEIDGSKLTHYLDFLSGVDTDIMNGKESETGIPFSNVIKFSFDDGSWYAVRPSGTEPKLKIYIYSRSKNKEEALSKVDRIERIVLGRIESVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E0</accession>
    <name>I2F5E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486989.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1457"/>
    <dbReference type="EnsemblBacteria" id="AFK07143">
        <property type="protein sequence ID" value="AFK07143"/>
        <property type="gene ID" value="Theba_1457"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1457"/>
    <dbReference type="eggNOG" id="COG1543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008192_1_0_0"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="7"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="428"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="534" mass="62374" checksum="A40EF2ABBADA9D3D" modified="2012-07-11" version="1">MERGRLILMLHAHLPFINHPDFPSFMEERWLFEAITETYIPLLQVFRRLKDDSVNFRVTMSITPPLMEMLANRDLQKKYINYLDSSIELAGSEISRTVSEHPAANRLALHYLKELQEIKSVYEECNRDLVGEFAQLQESGELEIVTCNATHGFLPLMTNFPETINAQVEIGVQSYKRHVGKDPRGIWLAECGYVPGFDSYLREHGLSFFFVDSHSFWYGDPAPRYGVYRPVVTPESVFVFARDPESSQQVWSAEVGYPGDARYREFYRDVGFDREEDYIRPYIDPSGERCNTGIKYYKITGKDVALNDKSYYDIDDARKATIEHARDFANRKREQVRRLSKQFDGEEPVIVAPFDAELFGHWWYEGPLFIEELFRELNGDETVVPSTPPEVIESMEQAQVVTPNTSTWGANGYNEVWLNGRNDWIYRHLDEGSRRMIELARKYERTEDPLKIRALNQMARELLLAQSSDWAFIITTNTTVEYAVFRTKTHIDRLLTLYREIESDSIDDHRLKTLEWIDSIFPYLDFRVYAKQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G4</accession>
    <name>I2F5G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ORF">Theba_1485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731098.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1485"/>
    <dbReference type="EnsemblBacteria" id="AFK07167">
        <property type="protein sequence ID" value="AFK07167"/>
        <property type="gene ID" value="Theba_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1485"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_0"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="113"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="334"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="115"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="498" mass="55740" checksum="B36FC6EE3F4224E4" modified="2012-07-11" version="1">MRLSQVIELLGNSVLQVVNPGNVDPEFDHIESDSRGLKERNLFICIKGTNFDSHLIARELQRKGAVALVAEMPIEDEEVVVPIVYVKSSRLVEALLTMEEYCHPYRKLTTIGVTGTNGKTTITTLIYHVLSSFERKASLIGTVRNVVGENIYTNPKNTTPGPVELAKLLQLSTKLKSEYFIMEVSSHSLSMNRVEGMRFDVGIISNVTRDHLDFHPTFDDYYRSKMKLFSLLKTNGIAVVNGDKINIADIHISRNRITTYGFGDESDYRIENLDISRTGMDFTIQTPYGSSHRIYSRLIGEHNAYNIAAAVAALNSLNYDLDHIAKAISSFGGVPGRFEFVEEATKYGFDVVVDFAHTPDALEKLLKTARRLTPGRLILVFGAGGSADKGKRPLMSEVSSKYSDVVILTSDDPKLDDPAEILQDLESGVDKFKPYLVIPDRREAISVALTLANRQDMVLIAGRGHEDFQILGEKRIPFNDKQVVKDILESKFRRHIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I0</accession>
    <name>I2F5I0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1501"/>
    <dbReference type="EnsemblBacteria" id="AFK07183">
        <property type="protein sequence ID" value="AFK07183"/>
        <property type="gene ID" value="Theba_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1501"/>
    <dbReference type="eggNOG" id="COG3091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1720166_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="152" mass="17499" checksum="93B44407584A060D" modified="2012-07-11" version="1">MDSADRNLATKARELSLSAFGVFPDIPFSFNSRLKRVLGRLVYSKSREMLTPLRIEISSSISDNEELLKKTLLHELSHFYLMMNDRDFSHNSPEFRKLSQELGFDIVAEYEGLPVHIWVCSVCKRTVAISFNRRRKNGLSSCCKAPIELQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L6</accession>
    <name>I2F5L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487148.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1543"/>
    <dbReference type="EnsemblBacteria" id="AFK07219">
        <property type="protein sequence ID" value="AFK07219"/>
        <property type="gene ID" value="Theba_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1543"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2735348_0_0_0"/>
    <dbReference type="OrthoDB" id="2204243at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="71" mass="8154" checksum="70461A10BA900936" modified="2012-07-11" version="1">MPRVIRLFQIRNEITDSDAERIVSRLKSLDGITKAQVDVASSVVEVEYENAIIDRYIIQEELSKLGFDMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L8</accession>
    <name>I2F5L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731132.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1546"/>
    <dbReference type="EnsemblBacteria" id="AFK07221">
        <property type="protein sequence ID" value="AFK07221"/>
        <property type="gene ID" value="Theba_1546"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1546"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_1_1_0"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="23561" checksum="4BA8E05C44876E70" modified="2012-07-11" version="1">MMKKLISHFFPNHCLVCEKEIDPAQYLCADCLGSIKGPIMTPFELKFVDSAFSYWKYESPLKELIRAYKFEDRPGIASLLSEMLFEMINTFSPAADVIVPVPTSIQAFVKRGFDTNLRILRRLSKTIDIRIDNVLTIAGKSIPQSRLKMEDRFQNVKDKFYLKRSPRSTSVILFDDVVTTGATASQCARVLKEGGVKEITLLAIAGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N8</accession>
    <name>I2F5N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731148.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1569"/>
    <dbReference type="EnsemblBacteria" id="AFK07241">
        <property type="protein sequence ID" value="AFK07241"/>
        <property type="gene ID" value="Theba_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1569"/>
    <dbReference type="eggNOG" id="COG4502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432992_0_0_0"/>
    <dbReference type="OrthoDB" id="1822108at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="189" mass="22298" checksum="D11F63474526B9C2" modified="2012-07-11" version="1">MKIMIDIDDILTNFNLAFLRIAHEMYDEVPIEVEVKIWDFWKSVPNLTLEMEERVWERIRNTPNFYESLPSYANDEDLRRLGELIGEGQHEVYFITSRFPTKGRNVQTQSQRWIQEEIGQPVSVIVSSRKGELCEVLGIEFAVDDAPHHIENLLDHGINTYIMDWPYNRHIDHRLRVKSLGEFLDSVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S4</accession>
    <name>I2F5S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR type III-B/RAMP module RAMP protein Cmr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731176.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1613"/>
    <dbReference type="EnsemblBacteria" id="AFK07277">
        <property type="protein sequence ID" value="AFK07277"/>
        <property type="gene ID" value="Theba_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1613"/>
    <dbReference type="eggNOG" id="COG1367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645474_0_0_0"/>
    <dbReference type="OrthoDB" id="1800053at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007522">
        <property type="entry name" value="CRISPR-assoc_prot_TM1795"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01894">
        <property type="entry name" value="cas_TM1795_cmr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="46510" checksum="CBC7C6E7D9D46A30" modified="2012-07-11" version="1">MQKSTFVCKTITPMLSRSMYSKTGKSWRFELRPQSVKGVMRFWFRALVPCVIDPNWLDGSKKPFAALHYLEGLMFGSQEKKSPFSLTVSYGDDIEESVNTLVESSDRFFRNALFGTYELKGDNPSFSYMMPDQSFTIRIRYSSSILPVQKTVTDSLMSLISNYSGFGAKARDGFGSFAISKAKGVEEDSVGEQYSTSKSLLLKMISELDPDERKFRLINEEPNLYPYDFPTLARSREMNSLIKSRSWKDIIGALTGQRTKDGDPVSKYSRLKLNELRKYGQPGDNLEPLRAAYFERTAPSREFVMRTSIMGLPIIYQRFGEYPGTTGKGTATVSNSNNSSGRKASPIFISVHKALNNSYFARILLMASKISPDRDNNDRPVIYAIVKGEPYPILGNENFEELWNLLKGVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T8</accession>
    <name>I2F5T8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DarT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731190.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1627"/>
    <dbReference type="EnsemblBacteria" id="AFK07291">
        <property type="protein sequence ID" value="AFK07291"/>
        <property type="gene ID" value="Theba_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1627"/>
    <dbReference type="HOGENOM" id="CLU_1388802_0_0_0"/>
    <dbReference type="OrthoDB" id="1585302at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029494">
        <property type="entry name" value="DarT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14487">
        <property type="entry name" value="DarT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DarT" evidence="1">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="196" mass="22844" checksum="F0ACD7D759D3BA80" modified="2012-07-11" version="1">MVTSSNPLQAFGVKHLYYLSPVKNIPSILEHGVMSKMAVETLEIPYDDYSDQTVQTIRERKSLHEYVPLFFNTRNAMTFRYQKENRDFAILRLNSDLVTHYDCLVSDRIAACSDAEIYTLSEPALKKINIEVVLSTRNFYDNWLLKKRLGAEILVKIDMIEPEWIECIILDRTAEKIKGISIRQLRDSGYTYYFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5U6</accession>
    <name>I2F5U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1636</name>
        <name evidence="2" type="ORF">Theba_1713</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
            <strain evidence="1">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1636"/>
    <dbReference type="EnsemblBacteria" id="AFK07299">
        <property type="protein sequence ID" value="AFK07299"/>
        <property type="gene ID" value="Theba_1636"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07370">
        <property type="protein sequence ID" value="AFK07370"/>
        <property type="gene ID" value="Theba_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1636"/>
    <dbReference type="KEGG" id="mpg:Theba_1713"/>
    <dbReference type="HOGENOM" id="CLU_2899017_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="62" mass="6752" checksum="340EB29B3CA85299" modified="2012-07-11" version="1">MCRSFRLPLTRLSVEVLIIANTASKMKVTMLPLLAVTGLSFKLRLAPRSSTSGDDSRLLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5V7</accession>
    <name>I2F5V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1647</name>
        <name evidence="7" type="ORF">Theba_1724</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
            <strain evidence="6">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731205.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1647"/>
    <dbReference type="EnsemblBacteria" id="AFK07310">
        <property type="protein sequence ID" value="AFK07310"/>
        <property type="gene ID" value="Theba_1647"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07381">
        <property type="protein sequence ID" value="AFK07381"/>
        <property type="gene ID" value="Theba_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1647"/>
    <dbReference type="KEGG" id="mpg:Theba_1724"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="170"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="388" mass="44581" checksum="9605A927EC1B888F" modified="2012-07-11" version="1" precursor="true">MKLNFKTREAMVGYLFAAPIIITILIFTIYPVFAGLYYSFTNYQPTEAQKFNMTFVPEESVSFHLGVFPDEEGLVKNELLSLFDPVTFLTLDMGVKLNAEQKEAVSSFLDTDKIVEDFLAGRLNSSVSVKDFMKEYMSSKSELFTRYVPEFVGLKNFREMFKDQYFWISLKNAFVYSIVVVPIQTLLAILLAVAANMKIMGQRFFKTVFFLPSISSSAAISMIFWLIYSKPGVLNRFLSTFGFQAVDWLNEPNTALGAIMVMNIWTTAGYFMITFLAALQSIPSSIYEASQLDGAKFWKTFWKITVPLLRPQMLFVSIMGIIGCLQVFDQIYFLIKNMRNITISYYIYKNAFEYHRMGYASAIAMVLFLIIFAITALQRKLIKEESYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F612</accession>
    <name>I2F612_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1706</name>
        <name evidence="2" type="ORF">Theba_1773</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">MesG1.Ag.4.2</strain>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731259.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1706"/>
    <dbReference type="EnsemblBacteria" id="AFK07365">
        <property type="protein sequence ID" value="AFK07365"/>
        <property type="gene ID" value="Theba_1706"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07428">
        <property type="protein sequence ID" value="AFK07428"/>
        <property type="gene ID" value="Theba_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1706"/>
    <dbReference type="KEGG" id="mpg:Theba_1773"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_4_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="46867" checksum="ED27C3AAC9B6F4B7" modified="2012-07-11" version="1" precursor="true">MRKLLLVTVLLLGVMLSATTIEVLWMGWPQDQVMQLVNAFKEETGIDVDIQLVPFGQLFQTIEVRLAAGDGTPDVYIVDGPNTASYAARGYLLPLDEHFSDEEMSAWFDASIEEGSYQGTFYSVPYGTSSAGIFYNKAIFEEYGVPFLPETIEERLTWEEVAEIAKKLTKDTNGDGLTDIWGLVIEQIDRPYLIFPMVQSLGAKVLSDDGLESQGYITSDEFVEGTTFYWKLFNEWKVSPQGLNDSAISREYFGTGRAAMMLGNEWNLRRMLQYPDVDYGLSPFPYFEGGVAVTPTGSWHVGINSKTKKLEEALAFTKYITGKEAVITWHKLNGIAPARPDVYEALPEVFDNPMWQLFVKEMETTAVPRPRTPGYSQYELMLREAFNSIHYGADPRSTLEEVAVRIDRELRKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F627</accession>
    <name>I2F627_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1646</name>
        <name evidence="7" type="ORF">Theba_1723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
            <strain evidence="7">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731204.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1646"/>
    <dbReference type="EnsemblBacteria" id="AFK07309">
        <property type="protein sequence ID" value="AFK07309"/>
        <property type="gene ID" value="Theba_1646"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07380">
        <property type="protein sequence ID" value="AFK07380"/>
        <property type="gene ID" value="Theba_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1646"/>
    <dbReference type="KEGG" id="mpg:Theba_1723"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="33794" checksum="293F6765A3A42BF1" modified="2012-07-11" version="1" precursor="true">MKKKLKIGMIIAYVVLILYAVVSLFPFLWSAIVSLTPMRYTENGVTTGTDIMKWPPEINLFKWPPEFFGAPATGENYVQVFKITPYARWILNTIIYAALVTIGHLIFDALGGYAFARLRFPLRDLWFALFLATLMIPGHVTLIPNYNLMVRFGFVNTYYGLFLPKLTGVFGIFLMRQFFMAIPREMEEAARIDGASIIKTYFKVVLPISKPAISALAIYIFVGTWNDFLWPLLMTSRKEMFTLTVGLDFYRTSYYTYWQYMMAASIMMTIPMIIIFLIFQRQFIDTGVSSGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F648</accession>
    <name>I2F648_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1678</name>
        <name evidence="8" type="ORF">Theba_1745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MesG1.Ag.4.2</strain>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1678"/>
    <dbReference type="EnsemblBacteria" id="AFK07338">
        <property type="protein sequence ID" value="AFK07338"/>
        <property type="gene ID" value="Theba_1678"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07401">
        <property type="protein sequence ID" value="AFK07401"/>
        <property type="gene ID" value="Theba_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1678"/>
    <dbReference type="KEGG" id="mpg:Theba_1745"/>
    <dbReference type="eggNOG" id="COG1785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_5_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="467" mass="50656" checksum="C4CAFB11067CD9ED" modified="2012-07-11" version="1" precursor="true">MKKALLLFSLVVLFALTALAGPKYVFLFIGDGMALPQINAAQLFLSSSFEDAVTPKLNMLRFPVQGMTTTYSSNSFITDSASAGTAIATGRKTNDGVISMDPTLTESYQTVAEFAKSRDMKVGIISSVSIDHATPAVFYAHEKSRNNYYSIGLQAVTSNYDLFGGGTFNRPDNKGKDRNLFEIAVENGFTVVRTQEEFESLESVEGKVIITNEVIPGSGAMAYEIDRENEFSLADITAKAIQLLSNDNGFFIMVESGKIDWACHANDAAASVGDTIAFDKAIAEAIKFYNEHPEDTLIVVTGDHETGGLTLGFAGTKYVANVPTIGNQKMSYEAFDALLSSEKALGKLNTFEDLLVLVEDNFGLVTTGKPQGIPLNDTEIERLREAFGYYVNGSVPKDSRTYILYGGYNPVSVTLTHILNEKAGLGWTSYSHTGVPVATFAMGVGQEMFAGFYDNTDIGKNLFKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F660</accession>
    <name>I2F660_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaerobic sulfatase-maturating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1690</name>
        <name evidence="9" type="ORF">Theba_1757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
            <strain evidence="9">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731244.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1690"/>
    <dbReference type="EnsemblBacteria" id="AFK07350">
        <property type="protein sequence ID" value="AFK07350"/>
        <property type="gene ID" value="Theba_1690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07413">
        <property type="protein sequence ID" value="AFK07413"/>
        <property type="gene ID" value="Theba_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1690"/>
    <dbReference type="KEGG" id="mpg:Theba_1757"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_10_0_0"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034491">
        <property type="entry name" value="Anaerob_Ser_sulfatase-maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00285">
        <property type="entry name" value="anaerobic_Ser-type_sulfatase-m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="412" mass="46901" checksum="748316CF2D052519" modified="2012-07-11" version="1">MAEGAVDRRTRESINAFHVMVKPTGALCNLDCAYCFYLHKQELINSRNVISDEVLERFIYEYINSQTVPEIVFTWQGGEPTLLGIDFFKKVVDYERLYCPPGKKIANDLQTNGTLLDEKWCSFLKEHNFLVGISIDGPERLHNVYRKSRSGGPTFQKVLNAVRLLHKYEILFNTLTAVNRINAKYPGEVYRFLRDTAGSTRMQFIPIAEPKVFKSSPTTFIPEDSMPITGSTEALPGKHASLVADWSVVPEDYGSFLNGVFDIWYREDIGKVFVFLFECALAQWLGMEASLCIFSETCGKALALEADGSLYSCDHFVYPEHRLGNIKDRRLLEMVTLTSQTVFGVSKAATLPEYCNKCEYLFACHGECPKNRFVKTPDGEPGLNYLCSGLKKYFSHIDPYMKKLAEEYRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J2</accession>
    <name>I2F6J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent protein deacetylase, SIR2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731347.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1897"/>
    <dbReference type="EnsemblBacteria" id="AFK07545">
        <property type="protein sequence ID" value="AFK07545"/>
        <property type="gene ID" value="Theba_1897"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1897"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_0_0"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="251" mass="27810" checksum="E57F08421BDA9FC8" modified="2012-07-11" version="1" precursor="true">MSRLSQEARNFISLIRESTCTSVLTGAGISVASGIPDFRSPGGLYSKISPDIFELSSFIEDPARYYRVAKERIHTMSDVSPNATHILLTRLQTLGLIETIITQNIDGLQQKSGAEEVVELHGTVSEFECMQCKRRFTRKEVELLLERSDVPRCDCGGLIKPSIVFFGEMLPQDAIRRAENAALKSDLFIAMGSSLMVYPAAQFPVIAKSSGARVAIVNRDETGLDYLADYIFSVELESFSEEALRLLDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R5</accession>
    <name>I2F6R5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731410.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1975"/>
    <dbReference type="EnsemblBacteria" id="AFK07618">
        <property type="protein sequence ID" value="AFK07618"/>
        <property type="gene ID" value="Theba_1975"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1975"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="554" mass="61889" checksum="6560E052E2926B8A" modified="2012-07-11" version="1" precursor="true">MRKILLVLIVAAAIVSIGFACTTIIVTKGASVDGSVMTSHSADCGLCDFRYVYVPPADYEAGAKRAVYPFVEPYPRYVGADMGPTYNDPDLPATEPLGYIDQVEHTYGYFDAVYGVINEHQLAIGECTCSAKVYAQPKAGECIFDVAALSRVAMERCTTAREAVELMGALAVEYGYYGWGETLTVTDPNEAWVFEICATPDKKSALWAAKKVPDGTVFVESNLFRIRELDPESPDNMFSPNLIEVATEAGWYDPSTGPIDWMATVSTGEYSMPYYSLRRTWRVFDRVSPSLGLSPWVEDSFTKDYPFSIVPDKKLSVADVIDLFRDHYEGTEFDLTEGLAAGPFGNPNRYAGSSKLIKGSWERALSIFRCEYVFVSQVRDWLPDPVGGVVWWGAAAPHETILVPMYCGITDVPYAYDSGSLQEFDYDVASWAFNFMGNWAELKWSYMYPEIQELQKKIEGKLFAVQPAIEAAAAQLYETDPELCKEFLTDYVADVTDRVMAEVWDFNEYLITKYRDGYINIPNVGSSAGYPDWWLDAVGYDEGHIFGEDGYKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S9</accession>
    <name>I2F6S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731424.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1989"/>
    <dbReference type="EnsemblBacteria" id="AFK07632">
        <property type="protein sequence ID" value="AFK07632"/>
        <property type="gene ID" value="Theba_1989"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1989"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="228" mass="25523" checksum="11295A48FEAC14C0" modified="2012-07-11" version="1">MADIIKLEEIKKEYGTVVKTEVLHGINLAIEESSFISIVGQSGSGKSTLMNIIGTLDKPSSGEVTISGRKTNKMNKNELAKVRNETIGFIFQFHYLLPEFTAFENVILPYRIKGLKPTKEVVERARELMDIVEISMVRDNLAPNMSGGQQQRTAIARALINNPKIILADEPTGNLDSDTSSKVFNLMRSLNKKYGTTFVIITHDRRIAEETDRIIEIKDGNIVNDITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F767</accession>
    <name>I2F767_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731538.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2136"/>
    <dbReference type="EnsemblBacteria" id="AFK07770">
        <property type="protein sequence ID" value="AFK07770"/>
        <property type="gene ID" value="Theba_2136"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2136"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="36701" checksum="58BBE0820DC40542" modified="2012-07-11" version="1">MERILEVDDLKISFRTQLGKITPVDGVSFGLSKGETLGIVGESGCGKTITAFSIVRLLPKNAFLGDKTKISFRGRDISTLSKQELQKIRGKSISMVFQEPMTSLNPLYTIGWQISEVYRLHEGLDEDDAMKRSIEMLRLVGIPEPQKRVKEFPHQLSGGMRQRVMIAMALACSPELLIADEPTTALDVTIQAQVLELMNELKSKFDTATIIITHDLGVIAEMCDRVVVMYAGQIVESGGVFDIFDKPVHPYTKGLISSIPKIDVAKKDQKKLNVINGYVPHPSNFPEGCRFRPRCPVAFEKCTQQPPVVQIERQHSVRCWLFEGRDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F772</accession>
    <name>I2F772_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731543.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2141"/>
    <dbReference type="EnsemblBacteria" id="AFK07775">
        <property type="protein sequence ID" value="AFK07775"/>
        <property type="gene ID" value="Theba_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2141"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_1_0"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="243"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="476" mass="52872" checksum="12CDF1F3114C467E" modified="2012-07-11" version="1">MKVASSKYLDDRRDLLRNLVSILENDFPYVSILGTDVKGKLFQVTTTGISVNDSRWSERGFVLRVHDGTGYFEFSFNEIDSESLNGIVELVKKRVAVFRKAMVKNNLEAAKTPIPEEKEWKLSFNDEVKILPGMLSAEEILGRLSNLKGKAHSLSEEVINVMTLMENVQVSKLFISSKKDLFQSYIWSQGYLYVVTRRGKMTKYSMKGFSGLKGAEILDEMDEYVEKVVENARMLLSAERINPGTYDVICSPDVAGLIAHEAFGHGVEMDMFVKERAKAVEYLGKQVASELVTMHDGAAGVREVSSYAFDDEGCEAKDTVIIDRGILLTGISDVISASILGTEPTGNGKRQSFERKAYARMTNTYFSPGKDDLEEMITSIDYGFLLEDYYSGMEDPKNWGIQCVIAYGREIVKGKLTGRIVSPVMMTGYVPTLLKSISMVSKDFRLSGTGACGKGHKEFVKVSAGGPYIKAKARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F779</accession>
    <name>I2F779_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731550.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2149"/>
    <dbReference type="EnsemblBacteria" id="AFK07782">
        <property type="protein sequence ID" value="AFK07782"/>
        <property type="gene ID" value="Theba_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2149"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_0"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="345" mass="37779" checksum="49AEDD4B936F283B" modified="2012-07-11" version="1">MKWIDIRSDTVTVPGEEMRRVMASAEVGDDVYGDDPTVNRLEEMSADILKKEAALFVPSGTFGNQLSILTHTLRGDEVIIPASNHIIVHEAGASAVIAGVQMRTLDCDDGKPSAERIRSAIRSEDLHYPRTGLICLENAHSSGRILPMNYIREIYELASAQKVPLHLDGARIFNAAIAEGVSPAEIASCSDSVMFCLSKGLGAPIGSMLVGKREFIAKARKGRKIMGGAMRQAGIIAAAGVFALERMIDRLQIDHDNAKYLAEGLSKLPKIEVFFDRLDINMVFFRITGKASSKFIVETLHDKGIKINPPEAGEWRFVTNLNVTREDLDIVLEEFEGALTRTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H8</accession>
    <name>I2F7H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731640.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2252"/>
    <dbReference type="EnsemblBacteria" id="AFK07881">
        <property type="protein sequence ID" value="AFK07881"/>
        <property type="gene ID" value="Theba_2252"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2252"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_7_0"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="308" mass="33630" checksum="07845D12FDE0C75E" modified="2012-07-11" version="1" precursor="true">MRKITVLLAMIFVLMAGILFATDVAVLLPGTVEFFSVQRVGLDAAAEEFGLNLIYADAEWDAGKQLSQVENFIARGVDLVLLCAADNMALRTAVTRCDEAGIPLITFTNSIGTDPEGKYPGVISHIGRSEIGSGVVQAEFVEKLFGNADIDIILIEGNPGTTAQRMREEGFLSVAERNPSWSIIEKRPIDGWTKEGTLAFMEAFLQSGRNVDVIACQWWSGAIAASMALKERGITDVVVLGLEYAKELVPYIEAGDVYASTYFSVIEEGYKAVEAAHLYLTGQEVPKFIEIQQVMVTKDNVADFEPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-04-07" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K4</accession>
    <name>I2F7K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diguanylate cyclase (GGDEF) domain-containing protein,uncharacterized domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_2279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2279"/>
    <dbReference type="EnsemblBacteria" id="AFK07907">
        <property type="protein sequence ID" value="AFK07907"/>
        <property type="gene ID" value="Theba_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2279"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014477_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="431"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="10">
        <location>
            <begin position="591"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="11">
        <location>
            <begin position="712"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="902" mass="101115" checksum="5801A55D3BC560F1" modified="2012-07-11" version="1" precursor="true">MRKKNISIKSIITIVSVSTMLFSTVVIGYLIISRWLSSAEKAAERIVENVGENIYNQVSSFMHIPQNVNEVNHKVIEYGILDLSNEELREKFFVGVLSAQSPHIYSFSYGTANGEYYGARRNEKGVIEIMRNDASTGGNSWYYSVNEDLTAGERVVQAGKFDPRTRAWYKAAEESGGPALCPLYKHFVMDDLTVSLSLPVYDASGSLQGVMGTHMLLSDIGRFLADAVRDYSGYAIVADKETGSLIANSMGVDNFTVLPDGSFSQRTVDDIGFPDIEKAFIQSTTNRESPLFYRGEEEKLFINMREIEILNATWVVMSAIPEAFYMKDVIDSIHLTVIIVVVALVLLLIIYHILARKLMKPLDNLIEVSTALSKGDLSKRVEVVRSDEIGMISESLNRVADKLQFLINNLEESVIERTRQLQRANEELKESKNELQLLLDSTAEGIYGIDLNGDCTFCNASSVKLLGFSGPEDILGKNVHRLIHHSRRDGTTFPIEECKIVRSIKHGRGFQTDDEVFWKADGSSFDVEYRSYPQMRNGEVVGGVITFSDITERKKREEEIKYLSSHDVLTGLLNRSSLAQIQKAVDVEENLPISVIVADINGLKMTNDVFGHAAGDELIKESARILLESCRERDLIARVGGDEFVVILPGTSEKETESIASRIKEGFSDARVQAVKCSISLGFDTKTRADQSLNEIMANAESFMYKDKTIHRKSLNRQLIDSIIDTLHTKYPMEKQHSIAVSELCGEIGSAMKLSQSQINVLKRAGYLHDIGKIVLDESILSKDTYTALTEEEREKIKQHSIVGYRILNLFDETLDIAEYTYSHHERWDGSGYPRGLKGEQIPLISRIISIAGAYDRVMNRVEGTLEEKREAALKVIREDAGKQFDPNIARLFIQMMDGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L1</accession>
    <name>I2F7L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731669.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2286"/>
    <dbReference type="EnsemblBacteria" id="AFK07914">
        <property type="protein sequence ID" value="AFK07914"/>
        <property type="gene ID" value="Theba_2286"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2286"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_1_0_0"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="281" mass="31541" checksum="A37D9435BD58D4FA" modified="2012-07-11" version="1">MLGAITGDVVGSRFEFNNHRDKNFELFTEDCFATDDSIMTLAVAKAIMETEKSINKSGIKSRADSDYLSLLRMLAIKYMQEIGRDYPNCGYGGMFGRWVFSDCPEPYNSFGNGAAMRISPVGFVAESEEEAVSLSGAVTSVTHNHREGIKGAEATVMAIFLARHGLSKREIRSRISKDYYPLNFKIDEIRDTYEFSETCQETVPQAIECFLESVSFEDTVRTAVSLGGDSDTIAAITGAIAQAYYGVPDWIRLKTLSYLDRRLRFIYDEWEAFLDRLGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L6</accession>
    <name>I2F7L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731674.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2291"/>
    <dbReference type="EnsemblBacteria" id="AFK07919">
        <property type="protein sequence ID" value="AFK07919"/>
        <property type="gene ID" value="Theba_2291"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2291"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="242" mass="26997" checksum="3B05628B523F80C5" modified="2012-07-11" version="1">MDDVVLECRNIVKHYGNVEALNGVSFELRKNEILGLVGDNGAGKSTLLKIIRGAVQPTSGEILINGKKVEFSSPMDAAEEGIQCVYQDLALVDQMTIVDNFFLGRELREKKLGFIPVLRKKKMENETEQALKQMEFSMDVNKKVSDLSGGQRQAIAVARAVFADPKIVLLDEPTSALSEIAKHEVFKLLKGLKEEHSLIFVTHDLNNTLQLCDRIIILKHGVIEYEGEVTKDLSLEELLSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N2</accession>
    <name>I2F7N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5, subtype I-B/HMARI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731690.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2308"/>
    <dbReference type="EnsemblBacteria" id="AFK07935">
        <property type="protein sequence ID" value="AFK07935"/>
        <property type="gene ID" value="Theba_2308"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2308"/>
    <dbReference type="eggNOG" id="COG1688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090888_1_0_0"/>
    <dbReference type="OrthoDB" id="1815464at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013421">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_HALMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02592">
        <property type="entry name" value="cas_Cas5h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="26938" checksum="DF5E12DDFD18E606" modified="2012-07-11" version="1">MKVLAFDISSDYAHFRQPYSTTSSLTYAIPPRTAALGIIGAIVGIESGGFGRSEHVAILEKANTKVGIRLMNKIEKTRFNMNYSYTKADVTTKNVLHIQVPVEMVRNPVYRLFVTADSELFEKLEGMVINSECYYTPYLGISEFVAKVKYVKTYEALIVETADEIWTAIEMLKKTSLSFSSGQKIFTETHAASMNSQRHVTRYVEVAYEAEGSSLKLQSVDPDSLLAKISTDAGDEVVMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S4</accession>
    <name>I2F7S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731725.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2352"/>
    <dbReference type="EnsemblBacteria" id="AFK07977">
        <property type="protein sequence ID" value="AFK07977"/>
        <property type="gene ID" value="Theba_2352"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2352"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295927_0_0_0"/>
    <dbReference type="OrthoDB" id="83075at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114966" checksum="F0277BA64B4AE8FF" modified="2012-07-11" version="1" precursor="true">MKKYILFVLSLSLIFLLLGCPAMNKSPEVVKLDGANGKVTTSSCTFLWSGSDTDGSIIRYEYRKDSADWESNGNETVYTWSEYSEGEHTFEVRALDNEGAYSETIVWSFNYDPPNVPPAVTKTGGVEGETEESSNTFSWNGNDPDGEIVRFELRKDSGEWIDTELSDEYTWNGYSEGEHTFEVRALDNEGAYSEITIWIFNYDPPNVPPVVTKTGGVERETEESSNTFSWNGNDPDGEIVRFELRKDSGEWIDTELSDEYTWNGYSEGEHTFEVRALDNEGAYSETIVWSFNYDPPNVPPAVTKTGGLEGETDNATNAFSWSGNDPDGTIVEYEYRKDTGAWIVNGMENEYVWGDYSIGNHSFEVRARDDEGLYSPTLVWNFEYVPHNNAPTVTKTGGIEGDTTRYLNTFTWTGSDSDGSIERYEYRKDRGDWISVGTDLSYTWRGYSEGNHVFEVRALDDGGAYSQIVIWSFTYSYANQPPVITKTGGLEGDIYVSSNSFSWTGSDSDGTIAKYEYRKDNGDWVDFGLGTNYTWSGYSEGSHSFRVRGRDDRGAYSEEALWSFTYSIPPQEMGAFKVVNSWGVGGWENVPDGFLYITYEAMKENQVRCFTIDPREDYEPRAIAVFEISHGIRDDCEITVGIGNPSSPIREKRFDDYSYRGGQHPFPDNKMVLDITELLPFEDETLFLKVFDSFSDFTTGSIEFFSVEVFDNYQSGTPVAIYTSTETPKNTVNNSFVNVQIHNVVAAQGSSYYLSSIRQGLSTEMLELLKADLGVLEEGRNYNEIIDGHGTGLRPPSEDDWDEIARTWHLMDGFSVQGSLPSTLDHSVSMYFPPVGDQGGEGSCVAFSNGYYTSTFYEARDRGWDLSGASWTNGGEPTPSYQNRIFSPDFIYHQINDGEDGGSSYLDAQKLLSRVGVSSWEKMPYDTSDHTSWPSESAWREAPRYRNGMNVISYLTVRTDQDILTIKSYLAAGYLVSVSIDANQYKNLTEKDVWNTSTYIYPDTNHANTIVGYDDNFNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U8</accession>
    <name>I2F7U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative photosystem II stability/assembly factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731746.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08001">
        <property type="protein sequence ID" value="AFK08001"/>
        <property type="gene ID" value="Theba_2381"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2381"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791812_0_0_0"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028203">
        <property type="entry name" value="PSII_CF48-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14870">
        <property type="entry name" value="PSII_BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSII_BNR" evidence="1">
        <location>
            <begin position="67"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="350" mass="38186" checksum="CDEAD80C804819CE" modified="2012-07-11" version="1" precursor="true">MKMKRLIWVTGLLLVAFVIGGCIPFPKVKNYRAWVVGQTDSNGIAMLYFSDDSGETWTRQAMDTLPEGKSLEDVLSVDQNRVWACGSDGLLLKTTNGGSDWEIVGVSEVATDSFFSFLSIFEDRIWVSGDEGLVIFSDDYGGSWTVCDLPEMASEYIIQGIHAINEDVIYAVGNKSTPRAGIVLKSEDGGQTWEEIELPNNYNDNGWIGVKATDENHIVIHGGQGHYVVTANGGKQWVTGGPLFAKDLNSLVMLDSSTYWAACDFDTIILTENSGISWEEQPPAGTSNSFLLGIDALDRSNALVVGSSAGYPQFGKILRTKDGGKNWEVVLSAEECPFTLAHVSIAEKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z7</accession>
    <name>I2F7Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731787.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2437"/>
    <dbReference type="EnsemblBacteria" id="AFK08050">
        <property type="protein sequence ID" value="AFK08050"/>
        <property type="gene ID" value="Theba_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2437"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_2_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657819" evidence="3">
        <location>
            <begin position="22"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="73"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="523" mass="58853" checksum="4DA3D725AD84A952" modified="2012-07-11" version="1" precursor="true">MKRSFMLVFLMVLIVAATGFAATPKDTLVIGANTGIFITMDPAVAYEVFPNKIVAALYAQLVKLEAIEGVIVPVPDIAESWEISEDGLTYTFNIRKGVKFSNGDPLTAEDVLFSLKRPIVLESVSAWFLVDIFGINKDNVDEKIKMIDDYTVSITLNAPYAENITLGILSNMFTGIVNKDVVLEHEVDGDLGGAWLTDHSAGAGPYVLVQWERNNVILLEANPNYYGNQPPLKRIMVRDIPEASNQRLLLERGDIDVAWDLTPQLLEEAKRNPDIVEVKVPGHSNEYLAMNATWGPLANPKVREAVRYSINYEEIVEDIMLNNALLVQGFINKGYFGYVEENPFYQDIEKAKALLAEAGYPDGFEVELLTSNTDTRKAEAEKIQADLALAGIKANIVIMQSSQMYAKYRAQGHQMIIAGWGNDYPDPDNLAMAHASYRAKQLAWRNAWFDDYAATLCEWGQVEPNPDKREQIYKDLTEYWFHNGPFAMLYQTVEFWGIRKEVKNFEEAAFGYGMLFDFTKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F802</accession>
    <name>I2F802_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731790.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08055">
        <property type="protein sequence ID" value="AFK08055"/>
        <property type="gene ID" value="Theba_2442"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2442"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_0"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="297" mass="32107" checksum="DBBAA336055DB621" modified="2012-07-11" version="1" precursor="true">MKKSEDGMAILAYVLVSFFWGSTYLAIKIGVEGMPPMFFAGVRFLIAGLIMIVFSAIRGYAFPASMREFSRLSLIGLFMLLGGNGLVVFAEQWVDSGVASLMMATIPIFAGVLEHFFIRTTRLTLKALLGLLLGFFGVYFLLIPAEHGISIDIPGILILLSASFLWSTGTVLSKTFKGKSSIVSNIGIQMFAGGVGLMFVSAITGEFSRVSFSMNSVLAIAYLIVFGSLVAYSSYIYLLQKWPATKAGTYAYINPLVAVSLGAIFLGEKINFLMILSMAAILLGVLIVQKSKIKVSE</sequence>
</entry>
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    <accession>I2F807</accession>
    <name>I2F807_9BACT</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="gene ID" value="Theba_2448"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFK08060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="138" mass="15762" checksum="5200B90B61FB99B0" modified="2012-07-11" version="1">MILGIFLKDREVSFFDGCLEVKIDRMEAFYAKVVLGGETPGVSFEDYMTTASVIVKRDENNMVILDFEDFAPPGEIRELRFTADDITLSVTLEDKETEEISQGFRDYRPPEDFLSYLKRNMKKSDNPLVTGEVEQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F837</accession>
    <name>I2F837_9BACT</name>
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        <submittedName>
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        </submittedName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
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                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
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        <property type="gene ID" value="Theba_2479"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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        <property type="entry name" value="MetI-like_sf"/>
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    </dbReference>
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    </feature>
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            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="289" mass="32228" checksum="8C0CDCA3BE9B3B8B" modified="2012-07-11" version="1" precursor="true">MAFQGTKINPRRFHRSQIKFYAILIPLALFMSLPIIFIFMNAFKPPNELFAFPPRIFVRNPTWDNFKALFNTVTQSGIPVSRYLFNSLLISLLTVLATILVGTAAGYVLSKKQFRLKKLLFEINTLALMFVPIAVMIPRYIIIARTGLVDSFLVHILPNLAMPVGLFLVKQFIDQIPDSLIEAARLDGANDWFIYGKIILPLTKPAIATIAILSFQTAWSSVEASNFYINQESLKNFAYYMSTLTSSTSAIAGQGVAAAAGLIMFLPSLVIFIFTQSKVMNTMAHSGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F841</accession>
    <name>I2F841_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellobiose phosphorylase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">Theba_2483</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2483"/>
    <dbReference type="EnsemblBacteria" id="AFK08094">
        <property type="protein sequence ID" value="AFK08094"/>
        <property type="gene ID" value="Theba_2483"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2483"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="136681at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="793" mass="89716" checksum="8A2132283CA51F93" modified="2012-07-11" version="1">MRLFESKYGYFTPDGREYVIVDPRTPRPWVNVISNGDYSMIASHTGSGYSWRGNAGQNRITRSYQDLIKDSWGKYYYIRDRESGRFWSAGWKPVMAQYSLYEVVHGMGYTIYRHRVEDIYSEMKVFVSAKAPVELAEITLKNEGATSRRLDITSYFEWVLGNFPDEHREFHKLFIVPAFRDNAIFVRKYLGQFPDGKGRWNNTDWNQIAFHGASEPVKSYTCDKESFIGMYGTQERPAALFEDELTGKCDRFGDPCAALQVEMVLVPGQSKSVVFTTGTAIIGEEDPEELLKSHSSVGASRRLFSELKAMWDGLLEAEKVETPDPGLNIMTNYWSKYQAISGRLWGKSGYYQVSAGYGFRDQLQDSQIFLVADPGLMRKQILLHAQHQFREGDVFHWWFTIGGGGPRTGCSDDLLWLPFITSQYVRETLDYGILDEELSFVDGGSATLYEHCRLAIEKSFKRFSPRGLPLIGEHDWNDGMNAVGSDWKGESVWLAQFMYLLLERFLPLSTKRGDGVFADRCRDVMQSLKDAVNEYAWDGEWFIRATKDDGGKIGSKENEEGKIFLNAQTWAVISDITDSERKAIAMDSVGRILLKDFGALLLYPAFTKPAPDIGYITRYAPGLRENGGVYTHAAAWAVWAFALMKDAASAYKAYSGICPPNRSVDIDRYMAEPYVTCGNSDGPVSPMYGRGGWSWYTGSAQWLHKVAVSWILGIRVEDGFMEIDPVIPPHWKGFKYTRKFKETVYEIEVRNPENLSHSVATVTVDGKGGGPKISIVNDGKTHKVVAILGRSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F893</accession>
    <name>I2F893_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transaldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731871.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2545"/>
    <dbReference type="EnsemblBacteria" id="AFK08146">
        <property type="protein sequence ID" value="AFK08146"/>
        <property type="gene ID" value="Theba_2545"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2545"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_0"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="222" mass="24811" checksum="10102CDDA1657507" modified="2012-07-11" version="1">MRLFIDDGNVQAISELFDLGFFSGISTNPSILKRTGRKPLEVIKDMLNRFTGSLFVQCASRGHDEVLKEGQELFGLDPERIILKIPFSRTGIRVLREFKKMNINTLITGVFSVPQVLMSAEAGADYVAPYANRIENLGIDLSVVGSMQKVLSNGDYETKLIAASFKTLTQISKMAELPIYGMSLPVGMYNEFFSHSGTLKAIDNFEADWDSIEDREWVPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F9</accession>
    <name>I2F8F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731920.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2612"/>
    <dbReference type="EnsemblBacteria" id="AFK08212">
        <property type="protein sequence ID" value="AFK08212"/>
        <property type="gene ID" value="Theba_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2612"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_0"/>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658742" evidence="1">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="412" mass="45903" checksum="E5B2C8D85925E916" modified="2012-07-11" version="1" precursor="true">MKKFLLLALVAIIAVSAFAGKVTIWSWRTQDAQVWEEVEAALKSKGLDITIEYTAFAPTEYDSKVALALQTGEGPDIVYSRRLPGGRTQVLIENGLYLPIDEFTDMSNFPQAALNSVTWQDKVYGVPFAVQVVGIFYNKDYYEEFGLEEPATWDELVANAEVIKNKGITPFFLYGKEAWALTMQHAMCGVSVLGPDWIKALTEGKTNFLDPKFTDLNKRLNDLKVYYQDGFMGNTTVDQDAAFAFGQAAMVFYGAWGYQTWKDLNPDLNVGYFMVPPLTEDQTPYAYTYLDGAIALTSNVKNLEDSKEIIKFCATPEFGTIFAGITYNIPAVLGASIPPDPLLEEVLDVYNNNASPWVYWVGSVFTTQKPSLYDDVLSPGMQALYAGKLTPEGLSQMAQDAISQWYPPLMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K4</accession>
    <name>I2F8K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487263.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2658"/>
    <dbReference type="EnsemblBacteria" id="AFK08257">
        <property type="protein sequence ID" value="AFK08257"/>
        <property type="gene ID" value="Theba_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2658"/>
    <dbReference type="eggNOG" id="ENOG50334DW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143404_0_0_0"/>
    <dbReference type="OrthoDB" id="1730371at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008338">
        <property type="entry name" value="Capsule_biosynth_CapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14102">
        <property type="entry name" value="Caps_synth_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01759">
        <property type="entry name" value="CAPSULEPROTC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="16442" checksum="97E4FFFF621CB218" modified="2012-07-11" version="1" precursor="true">MSPALFSIGIVISTAFWWVTGLSAGGLVTPVYLFIFMEQPLRLLYTWAVGLVTFLILNLLQRYLILYGRKRMALGIVLGVFVKLSLDTFLMPNLPVELFSTVIGTIVPGLIANDFYRQGIIKTSLSLAFVTLLLWLIDTLIRTVMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R9</accession>
    <name>I2F8R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732015.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2727"/>
    <dbReference type="EnsemblBacteria" id="AFK08322">
        <property type="protein sequence ID" value="AFK08322"/>
        <property type="gene ID" value="Theba_2727"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2727"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="32668" checksum="4D7A951F0BD40150" modified="2012-07-11" version="1" precursor="true">MRSKRWVPWAFLALPLTMYSIWVIYPLISTLLLSFTSWDGVSMSKDIIGLDNFRELFRDPYFIVSLINNIKWLIGFAVVCVPAGLGIALLLDQNFRGNKLYKTLVYLPMTLSFVVIGQIWSWILEPRSGVLNSFLALLGFKGVSWLSDPSVVTYSLIMAASWRQISYAMVLFLAGLKGVPRELVEAATVDGAGPWKRFWNVVLPMLKPATVVAVTVSVIDSLRAFDIVYVLTRGGPFYSSSVMANYMYIKAFNNYRMGYGSSIATIQFLITLVFIVVYMRNVLKKEVGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G7</accession>
    <name>I2F1G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487445.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0015"/>
    <dbReference type="EnsemblBacteria" id="AFK05770">
        <property type="protein sequence ID" value="AFK05770"/>
        <property type="gene ID" value="Theba_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0015"/>
    <dbReference type="eggNOG" id="ENOG502ZT8V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2617907_0_0_0"/>
    <dbReference type="OrthoDB" id="2055378at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="78" mass="9452" checksum="66B7079A672EF373" modified="2012-07-11" version="1">MERYQELELVVDKMVEEFTRLRKENEQLWNQLETSQKKVEESELRIRELELRLESESRTISSLIKRVRGSLVEDSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K9</accession>
    <name>I2F1K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729986.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0061"/>
    <dbReference type="EnsemblBacteria" id="AFK05812">
        <property type="protein sequence ID" value="AFK05812"/>
        <property type="gene ID" value="Theba_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0061"/>
    <dbReference type="eggNOG" id="ENOG502ZJ5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303684_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="211" mass="24571" checksum="46D9687E93E7D055" modified="2012-07-11" version="1">MLLAVGSTSRGTDTHWSDLEMLMITKEEVPKKTFLKGLVPVTTNSITEKILCGILEEPGVEWPFYAGLVKNLVVLEGDASKPEQYYDLARSVPEEKFRRALKENLSELVFESCGRIFSCIARKRYEDVYCAVIETLLEMKTVLCLLKCTHVNHDYFEGLQESFKFRKLPERYPVLATRLWRSRSPFDIANYSRDLFRNYLSLLREERLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L4</accession>
    <name>I2F1L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitamin B12 dependent methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729991.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0066"/>
    <dbReference type="EnsemblBacteria" id="AFK05817">
        <property type="protein sequence ID" value="AFK05817"/>
        <property type="gene ID" value="Theba_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0066"/>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105790_0_0_0"/>
    <dbReference type="OrthoDB" id="1410233at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoMet activation" evidence="2">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="232" mass="26547" checksum="C110150A796F707D" modified="2012-07-11" version="1">MVEREKNIAVLKGIPFDIDLASLGESLRIRAGSEEESTLKELVKCARKTANPKAIYRTCFVDCVNGDEVTIEGVRFESRLLSKKLHSVGRVFPFVITSGRELYEYPLDRADFLKIFLWDSLLEHILSEAAEFMRREISRNNLIENLVWMSPGSGDAEIWPLQQQKELFSLIGNVKEEIGVELKESLLMIPTKSISGIAFQSEKDYRSCMVCKRVNCNYRSAPYDEKLRNSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P9</accession>
    <name>I2F1P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Theba_0103</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490184.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0103"/>
    <dbReference type="EnsemblBacteria" id="AFK05852">
        <property type="protein sequence ID" value="AFK05852"/>
        <property type="gene ID" value="Theba_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0103"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_104_15_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="342"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="695"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="847"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK05852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="935" mass="104174" checksum="1121F1678E20E4AC" modified="2012-07-11" version="1" precursor="true">MRKLSRKISLQFLLFVLAVLTVLVALLSVTFVRTATDEYKSYLSSKKQSVFQWFIDLRKDMKVFVDGYSLEGVIDDGCDILIRLGDERKTILNRPAISEGQLNEIEEAENGFKMLEGQLVYFSTVESNESRYVAGIVFDNEDVEELSAFLGQDGIAFLLIDDHFVIPREFSDSGLYVRTVLDEERWSSEIPFTVSEPRPAFSFFSSGSLFLADKVSIGGADIYVLQSEGLMVMLRNRLLPILSIVLLGVFGFSFVLSFTLNAHISKALSELLKGFESIKKGSFVRVKLNSNDELGEIASELNNTMVFIEKTLDRLKNSNEMLRKVSKEAQQASKMKSEFLANMSHEMRTPMNAILGFAELLMNDETNLEKMKYLKTIYRSGEHLLSLINDVLDLSKIEAARFDLIISPYSPAKLVKEITETYLPMAYSKGLHFANSITERVPEYVDGDEFRVRQVLTNLVSNGLKFTDKGYVSVLLDYDGHHLIYTVQDTGSGVSREEIDKIFEPFIQADGTMSRKFGGTGLGLTITKKIVELMGGSIRFESKVGEGSKVTVRIPSNVSKEVPKQKEKPELPPTGKVVVASDDEDFLTIVGAMLKRNGVHYESVKNLSNLSRAVRELGASLAVVDAPKNADDALAALDGIDEAAVIVITDTTENEIHFGKKVNEIIQKPVKEDELIGKIGNYMDLGPGQDNVKYRILLTEDNEANQLLIKEVLEKAGYSVDVAGNGKQAIEMVRNFNQYNLILMDMQMPIMDGYEATKALRQEGYKIPIVALTAHTMQGDEEKTIEAGCDGFLGKPVRQSDLLEIVRYHLGIFGKTGNKRSGVRPIQREGKHSPDNITVFAKDMGLSMEEASAMFEEYGKHIDKTVATLESALERKDMGSIAREGHSLKGSGRMYGVEEISGVGFKIETAGKSGDENQISDGIAELKRIYRKLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y7</accession>
    <name>I2F1Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tsf</name>
        <name evidence="7" type="ORF">Theba_0205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730103.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0205"/>
    <dbReference type="EnsemblBacteria" id="AFK05940">
        <property type="protein sequence ID" value="AFK05940"/>
        <property type="gene ID" value="Theba_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0205"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_0"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="6">
        <location>
            <begin position="52"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="201" mass="22939" checksum="675B9FEBE9C19785" modified="2012-07-11" version="1">MANITSDMVKKLRDATQAGMMDCKKALVETDGDFDQAKDYLRKKGILKADKVSGRETAEGLVYSYIHHNDKLGVLLELNCVTDFVARMEEFKELAHKIALQLAAMGARFISREHVPQEIIDKEKEIYTEQMKDSGKPANIIERIVESKLESFYKDNCLIEQEYVFESGKTINDLLVELIAKTGENIKISRFVRWQVGESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z9</accession>
    <name>I2F1Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name evidence="2" type="ORF">Theba_0218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730114.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0218"/>
    <dbReference type="EnsemblBacteria" id="AFK05952">
        <property type="protein sequence ID" value="AFK05952"/>
        <property type="gene ID" value="Theba_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0218"/>
    <dbReference type="eggNOG" id="COG1323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038915_0_2_0"/>
    <dbReference type="OrthoDB" id="1547014at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="427" mass="48953" checksum="795D78AA23D64BF0" modified="2012-07-11" version="1">MKVLGLVVEYNPFHYGHLYHLEKSKDLVKPDVTVAVMSGNFVQRGEPAIVEKFARAKAALKQGIDLVVELPVVYSLQDAGGFATGAIWTLDHIGVTDIVFGSETDDTELLKKVSKILIEEPEYYRDLLKKHLKKGHSFPNARKYALRDFIHIEDKNLSHRIEEIGSSNNILGVEYLRAINKIGSKIAPLSIKRVGSSYTDEEHRGKFSSATAIRKLIQKGDIESASQAIPKEPFDIILQEIRSGRGPVFKEDVESFFISFYRLLSRDDYNRYYGFVEGLDARFQECSLSGSLEEFLHCVKSKRFTLSRIRRLMYYPVFRFTDNLIRKSNEFGPQYIRVLGFNEKGRNHLSNIKHSMKIPIITTVSLWRKVVDGALKKEMKIDADLLEAQLERDFAAVRFYASLFKYPESRSRCSDLLSRVIYNEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F214</accession>
    <name>I2F214_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0233"/>
    <dbReference type="EnsemblBacteria" id="AFK05967">
        <property type="protein sequence ID" value="AFK05967"/>
        <property type="gene ID" value="Theba_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0233"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046133_1_1_0"/>
    <dbReference type="OrthoDB" id="1223448at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="391" mass="43627" checksum="71EF597E988AC20E" modified="2012-07-11" version="1" precursor="true">MSKIAFGRWLAILAVLTFLSANCVGAIEIDFFGVATCQECFEAEMMIESLKYEVEDEVVLNKFMLSEAENQELKLKYAKVYGVSESELDLYPMIFIGKDAFTPLNTTPDSVLESMINYSQEERETKLREIEALGDDVTHRLNDRYEQFSLFVVLGAGLIDGINPCAFVVLIFLVSYLYYVGRGRNEILIAGIFFAVGIFAAYLAMGTGLLGAVGYVESISKVFQLIFYPAMAIFTGLLAVLSVVDFYRMRYRNKKAILELTPGLKKKTHEIIRKNARAKTIWIASLVTGILVSFVEFMCTGQVYLPTIVYIINSSGVTGRALGFLVAYNLGFTVPIIAITLIAYFSSSTKRIQEFMTSTQAAAKIKLLMGALFTVFFVIMLNITLKTFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F223</accession>
    <name>I2F223_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730137.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0242"/>
    <dbReference type="EnsemblBacteria" id="AFK05976">
        <property type="protein sequence ID" value="AFK05976"/>
        <property type="gene ID" value="Theba_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0242"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062584_1_0_0"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027024">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027386">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="306" mass="33371" checksum="9BD88A93EBB04265" modified="2012-07-11" version="1" precursor="true">MRKFVAVSALLFITLFSFGVNYINPVGPTLIPIAELLSSNLSEEIPGLEINLWRSVDEAISMMVTEKAQIALLPVTVGVKLASSGVDIKLAAVSMWNGFYFISTEKTIEDIEDLVDTEVYTLQAPGQTADTILRGALESKGYEVGRDLDIVYVGGAEAVQLLAGGKAKVILVPEPFASLAETRVQGSIRSMPIEDLWESFNEQRINIPTSGIFVSGTLDRGVAESFLLLYQQSMNLSLTNREKTAATVSEKMGGFPAPVLQKAMDTAGFLFLTAEDAREDIAIYLNRLKELDPELTGDFDIDALFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F252</accession>
    <name>I2F252_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="9" type="ORF">Theba_0273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491739.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0273"/>
    <dbReference type="EnsemblBacteria" id="AFK06005">
        <property type="protein sequence ID" value="AFK06005"/>
        <property type="gene ID" value="Theba_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0273"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_0"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="7">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="175" mass="20275" checksum="00CCA42FEF79E9AD" modified="2012-07-11" version="1">MTKTVRLVDMNGEQLGVVQTSEALRIAREKGLDLVLVAPAANPPVARIMDYGKYKYEKDKRKKEAKKKTKQSQLKEMKFRIRIDEHDFQTKTNRIKEFLEKGSKVRVVIMFRGREIVFSDKGREILERVADQLQQISDIDRPPKLEGRDMWMILKPKTTPQGGKDNGQQSKNEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F262</accession>
    <name>I2F262_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="9" type="ORF">Theba_0283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730170.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0283"/>
    <dbReference type="EnsemblBacteria" id="AFK06015">
        <property type="protein sequence ID" value="AFK06015"/>
        <property type="gene ID" value="Theba_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0283"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_0"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="438" mass="48738" checksum="67B19B44055320F1" modified="2012-07-11" version="1">MFENLQEKLGRAFKLLSGKGRISEKNIEDAVKQVKLSLLEADVNYKVVKEFIGGITEKALGEEVLKSFTPDQQFIKIVRDELIKMLGEKSVPLKLSSQPSKIMMVGLQGSGKTTTTAKLGTLLRKEGRKPLLVAADVYRPAAIDQLMQLGKQIDMPVFTGDRKNPVKIVQEAMQQAVRNINDVVILDTAGRLHIDDAMMRELKEIVSAVKPDEILMVVDAMTGQDAVNSAKAFNEALELSGFVVTKLDGDARGGVILSIRHVTGKPVKFIGISEKPDGIEAFHPDRVAGRILGMGDVLSLIDKLQYNIDEEKAKEMEEKFLKNKFDLEDFLDQLKEVKKLGSIADIMEMIPGAPKDVDLAGSEKSMKRTEAIIHSMTSKERRNPKLLNYSRKQRVARGSGTTIQDVNKLLKSYDQMRSMMKQFGRKGKLLKGMKGFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C0</accession>
    <name>I2F2C0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="10" type="ORF">Theba_0344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491918.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0344"/>
    <dbReference type="EnsemblBacteria" id="AFK06073">
        <property type="protein sequence ID" value="AFK06073"/>
        <property type="gene ID" value="Theba_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0344"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_0"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="342" mass="38186" checksum="B0C197921154E12B" modified="2012-07-11" version="1">MNLNLLEALDQLQDEKNIEKEEVIDILEKALQSAYKKNFASESDVDVRIDRLTGDIEVFEKLLVVEAVENPSLEVKLEEALKLDSSAEIGSTVERKLNIKKFKRIAAQTARQVLIQKIREKEKENLFDKYVDMKGTVTTSEVLRVTDEWIDLRIGKLETRIPTKELIPGEQPRLNSLMKVYVVDVTKSVRGPRLLVTRRTPDFVIELLKLQVPEIASGDVTVKAIAREEGIRTKVAVFSQNTKVDPVGACIGESGTRIAEVLREIKPEKVDILRWSDNPAEFVGNSIAPASALEVKVANIENHEATVFVSPTQLSLAIGKGGQNARLAAKLTGWKIDIKPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F9</accession>
    <name>I2F2F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491973.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0384"/>
    <dbReference type="EnsemblBacteria" id="AFK06112">
        <property type="protein sequence ID" value="AFK06112"/>
        <property type="gene ID" value="Theba_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0384"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149981_3_0_0"/>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="92" mass="10600" checksum="BE6E8952D2D763E6" modified="2012-07-11" version="1">MHVGYMTYLLRLYGISSLKEKRAVIKPVLNDLRRKFNASVVETGKHDSKQESEITVCMVANERGELDSLFQSVWQRIIWNGLEVSGEDGEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H1</accession>
    <name>I2F2H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0396"/>
    <dbReference type="EnsemblBacteria" id="AFK06124">
        <property type="protein sequence ID" value="AFK06124"/>
        <property type="gene ID" value="Theba_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0396"/>
    <dbReference type="HOGENOM" id="CLU_3119628_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="50" mass="5744" checksum="102C9A32BDA527D5" modified="2012-07-11" version="1">MPERSLWDDEHYFGVIAVEKTLPSSDFNEEAIAFSVLRGSSMVLFPDHSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I0</accession>
    <name>I2F2I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492001.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0405"/>
    <dbReference type="EnsemblBacteria" id="AFK06133">
        <property type="protein sequence ID" value="AFK06133"/>
        <property type="gene ID" value="Theba_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0405"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="270" mass="30006" checksum="7979B2E61CFA4CC3" modified="2012-07-11" version="1" precursor="true">MIKRILIYALLTVFALFFLMPIYVLLATSLKPLKEVGLERMWFPPNDLSFDGFAKAFSRLAPNLRNSFLLVIPATLLSAIVGSINGYVLSKLKFRGSDLLFALVLFGMFIPYQSVLFPLIRFLQDIGLYGSIWGLVLVHVVYGLPITTLIFRNYYSEVPTELIEAANIDGAGIFKTYLKVLFPISLPGFVVVVIWQFTNIWNEFLFAVTVTSDPTKQPITVALVNLAGSQVVEWNVQMAGALLAALPTLIVYILLGKYFLRGLLAGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V8</accession>
    <name>I2F2V8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="13">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">metG</name>
        <name evidence="17" type="ORF">Theba_0538</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="13"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492167.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0538"/>
    <dbReference type="EnsemblBacteria" id="AFK06261">
        <property type="protein sequence ID" value="AFK06261"/>
        <property type="gene ID" value="Theba_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0538"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_4_0"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:tRNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Anticodon_Ia_Met"/>
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        <property type="entry name" value="MetRS_core"/>
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        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="tRNA-bd_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
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        <property type="entry name" value="SSF47323"/>
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    </dbReference>
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        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRBD"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13 15" id="KW-0648">Protein biosynthesis</keyword>
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    <keyword evidence="6 13 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="534"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="13">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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            <dbReference type="PROSITE" id="PS50886"/>
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            <dbReference type="EMBL" id="AFK06261.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="635" mass="72887" checksum="BC659F513296C6C2" modified="2012-07-11" version="1">MEKFYVTTPIYYINSEPHIGSAYSTIVADVIARYRRLSGYDVFFLTGTDEHGQKVLNEAIERNVEAQKYCDEMAEKFKALWKELELTNDAFVRTTDEYHMKTVQTFVSKLKENGDVYKGKYEGWYCIPDETFWNEEDLKEGRTCPECGREVKWVSEENYFFRLSKYNDILLRFYKENPQFVQPDFRRNEMLRILESGLKDLSITRTSFDWGVPMPDDPEHVIYVWVDALINYLSAIGYPHNIDHFERYWPADVHLIGKEINRFHSIIWPAMLLSAGLPLPKQIYAHGWLTVNGQKISKSLGNAISPVAFVRTYGNDALRYYLLRDIQFGRDGDFSETNLISRINADLANDLGNLLHRTVVMIQKFNDGAVPERSITETIDEDLVELGEKTFSAYTESMDNMRFTQALESVWELIRFGNKYIDLTEPWKMGKKPEMKGRLDTVLHNLVCTLKNVSIMIEPVMFRTAREIRKRLGFGGTMTLENVSWSDIVAGKRVSHGEPIFPRIEIEKHRKVTEMENKETGPEIKDNLLISIDDFSKVELRVASVTEAEIVPKSRKLVKLQLDLGDLGRRQVVAGIAQFYNPEELVGLKVVIVANLQPAKLMGIESNGMILAAKIGDSLSLLTVHKDVQPGAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F300</accession>
    <name>I2F300_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ChAPs (Chs5p-Arf1p-binding proteins)</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_0584</name>
    </gene>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
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        <property type="protein sequence ID" value="AFK06303"/>
        <property type="gene ID" value="Theba_0584"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="356" mass="40829" checksum="119D23CA5A38C9BF" modified="2012-07-11" version="1" precursor="true">MEIIRLKKDKKSFDITDTLPFAIAILDEVYDGDINVAIHDLKSTKIGKDLLTIGGLAETFDNVVTPENYAPIEYEEFNDYLKETGLSVASFTRGTFSGFQDKILSIADRGDYESAQKFLDLLMDANVDKATVCELKGSIFLESGDEEEGIKWLQNALKIDSSLVTAYSFLGQTFYNRGDFDSAADCWQREIAASPDHLVTYFMLTDAYINAGRMDEALNVLKDLSKRDPDSILTKVEMAELYEKMGNIEMRRIVEDEVLKTKPVYINDVEPWAKIQFKHSNYDVVEEVATNFLKENPDRPELKMLLVVSHMKKGQCDEAKRLLKEFENEQVWYFYGKKELFDEYLTEEERKQCGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F349</accession>
    <name>I2F349_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_0634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0634"/>
    <dbReference type="EnsemblBacteria" id="AFK06352">
        <property type="protein sequence ID" value="AFK06352"/>
        <property type="gene ID" value="Theba_0634"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0634"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_0_0"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="65"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="373" mass="40791" checksum="AE64173D837EB5EF" modified="2012-07-11" version="1" precursor="true">MTSFICSKCGRKFPLGSKAFKCSCGGLFDLKFEPHFPIANIEQRPHNMWRYREALPIESDRSIVTMSEGYTPLIEEEICGKNVFIKMDHLLPTGSYKDRGASLLVSYAREHQVSSLVEDSSGNAGCSIAAYSARAGISCEIFVPDHTSVGKLRQIEAYGSKVRLVEGSREDVSRKILEQTKENFYASHVYNPLFLHGTKTLAFEICEQLGWKSPGAIVVPVGNGTLLLGASIGFGELYSAGIVDHLPKIIAVQAENCAPLLRAFEMNQKDSADVNAEATVSEGIAIEKPVRGAQILKAVRDSGGTFVGVSEQEIIETWKEMSKRGHFVEPTSAATIAGLKKYISKTDPNETIASVFTGHGLKTACELFSWNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F352</accession>
    <name>I2F352_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rlmN</name>
        <name evidence="14" type="ORF">Theba_0637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730432.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0637"/>
    <dbReference type="EnsemblBacteria" id="AFK06355">
        <property type="protein sequence ID" value="AFK06355"/>
        <property type="gene ID" value="Theba_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0637"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_2_0_0"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="96"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK06355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="339" mass="38317" checksum="33E2045C4BD43E00" modified="2012-07-11" version="1">MKDILSLDLDELRREIISFGEKDYRANQIFKWVYAKRVLDFSEMTDLPMNLRNKLGSLFRFTTMKEVERQISIDGTEKFLLKLEDDNHIETVVLKHPRHVTFCISSQVGCALNCSFCATGASGFTRDLSASEIVSQVILMENSIGRPVDNIVFMGMGEPFLNEANVYKAIKILHDPVGRNLGIRHFTISTAGIPEGIKRLADSGMDVRLSVSLHSASEETRSSLMPINKKYPLDSLRKVLDYYQQKTGNRITFEYALIKGVNDSKEDLTKLGEFLTGIKSFVNIIPVNPVKPVFDRPSDREIAVFSESLKKAGFECAVRHEKGTDIEAACGQLRQKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F377</accession>
    <name>I2F377_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0663"/>
    <dbReference type="EnsemblBacteria" id="AFK06380">
        <property type="protein sequence ID" value="AFK06380"/>
        <property type="gene ID" value="Theba_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0663"/>
    <dbReference type="eggNOG" id="ENOG5033UFM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364729_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="202" mass="23820" checksum="292DDC64088375EB" modified="2012-07-11" version="1">MNFRYAHILYRGDDFLTPKRATFDHRTKTGFMTTWSTDQSAELLKHKYWNCLSAYGLESAMRRKITFERKHSDSNLLYFKYELEVPEALEGYFDQTTFEVISKNLSIRETTEEVYKMLKDYEEGSLSFNDQRFSSWLAMKTGELQLSVNEKKELEKSLIKYVETIVGRILWAVYNGDLPKMGKDLSSIVYLYTEMLDLIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C2</accession>
    <name>I2F3C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">Theba_0708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0708"/>
    <dbReference type="EnsemblBacteria" id="AFK06425">
        <property type="protein sequence ID" value="AFK06425"/>
        <property type="gene ID" value="Theba_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0708"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="280"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="292"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="534" mass="60780" checksum="3021195DA5BFD10F" modified="2012-07-11" version="1">MSPRKKKTEETPNELDENVVSEKKPTRKRTTRKKTEVKKPEKKEETLSATSNEIERSMKENEVSLKGDAEKKMDSESEFQESTSESATDESKELPRKDKDKDKDKDKDNIREVEIDISQLQAMPIREVYKLARKYDVQGYTQMAKKDLIFAVLKAQTESYGYFFDQGVLEITDGGYGFLRTLDNNLLPSSNDIYVSQSQIRRFNLTSGDTVAGQVRPPKEGEKYFALLRIEAINHKAINFAAERITFQNLTPIHPEDRLITETDSHIMSTRMVDLFSPIGKGQRGLIVSPPKAGKTILLKELANGIAENHPDTIRIILLIDERPEEVTDLRRSTNAHVIAAPFDMHPEKQIRVAEMTIEMAKRLVEFNYDVVILLDSITRLARAYNLYVPPSGKLLSGGVDPSALYKPKYFFGAARNIEEGGSLTIIATALVETGSKMDEVIFEEFKGTGNMELILSRQLANKRMFPSINLTLSGTRREELLLPSDILRKIWILRRMLSSMSEEEGLRLIMEKLRGTGSNDEFLDLIEMEKKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C4</accession>
    <name>I2F3C4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name evidence="2" type="ORF">Theba_0710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730485.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0710"/>
    <dbReference type="EnsemblBacteria" id="AFK06427">
        <property type="protein sequence ID" value="AFK06427"/>
        <property type="gene ID" value="Theba_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0710"/>
    <dbReference type="eggNOG" id="COG1515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_0"/>
    <dbReference type="OrthoDB" id="1681607at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="25131" checksum="F8FDC6F9AD891667" modified="2012-07-11" version="1">MNIEYIHSWSMEPVQAIDLQKKLRDKLTFEDYSREPRLVAGIDVSFPFREIALAVIVIMEFNSLSIVDHFFSLKKVETPYIPGLLSFREGPAILDALSRSPEVDLLFFDGHGIAHPRGIGIASHIGLFVEIPTIGVAKSLLYGKVESLPREKGQSSRILSPGGRLLGYALCTRTSVKPVFISPGNRITAESALRLSIRTIGKYRIPEPTRQAHILTQRLKNQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E9</accession>
    <name>I2F3E9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ORF">Theba_0737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730508.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0737"/>
    <dbReference type="EnsemblBacteria" id="AFK06452">
        <property type="protein sequence ID" value="AFK06452"/>
        <property type="gene ID" value="Theba_0737"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0737"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_0"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="232" mass="25513" checksum="776CE4D516F6CCCB" modified="2012-07-11" version="1">MPVRSKRYIQARKSVDRNVSYSVDESIDLLKNFPPTKFDETVEMHLKLSIDPAKSDQQVRGTIALPNGTGKDVRVLVFARGEQAETAKRCGADFVGSDDLVQQIQGGWTDFDVAIATPDMMRDIGKLGKVLGPRGLMPSPKAGTVTADVEDAVKGFKAGRLEVKNDKTGNLHLPIGKKSFDKEKLRENFVSALNQIMKMKPAGSKGRFVQRVFLTTTMGAGIKVDFARETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F2</accession>
    <name>I2F3F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="14" type="ORF">Theba_0740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730509.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0740"/>
    <dbReference type="EnsemblBacteria" id="AFK06455">
        <property type="protein sequence ID" value="AFK06455"/>
        <property type="gene ID" value="Theba_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0740"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_3_0"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="11">
        <location>
            <begin position="25"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="12">
        <location>
            <begin position="473"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="13">
        <location>
            <begin position="551"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="678"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK06455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131912" checksum="028031AE7BFE66BA" modified="2012-07-11" version="1">MRKANFGKRERWVFGRVYEPLEIPNLIEIQTRSFEWFINEGLLNVLKKYSPIKSQIQRSDLKKGEKGFSLDFVATRIGEAKHSIQECKDKGLTYSVPLYVTVRITDLYTGEIKEEEAFFGYLPYMTDNASFIINGAERVIVNQLVRSPGVYFVDEPTKAVSGSLPIYVAHFLPVKGAWYEILLNPNKQIMQARIDRRRKLNFFVFLKALGYENDLDLLRLFENEYDGSDEDELLANVGSMILEDVKTPGGDLIAEKGTLLTEEIIARAIEADVKTIKMPLPIAMKTFNALQKTYGEGMTEDDAYIELFRKLRPGEIPRINAAKSYIANLYFSPDRFDFSDVGRYKVNSRLKKVYQDYLKEVEGKKVSKDTDYSEESSILTVLDVVLAARHLTEIESRPELLDTKDHLGNKRVRTVGELMETEFEKAFIKIHKLLEEKLTIYTSFDKISVQSLVNVRTLMTTLHQFFATSQLSQFMDQVNPLAELTNKRRLSAIGPGGLKREHARFEVRDVHHSHYGRMCPIETPEGANIGLMTSLATFAKIDKYGFLLTPYRKVQKGAVTNDIVYLAADEEERYNIAHSTVDMDEKGNIVDENVEIRYAGEVRYVNREEVDYMSVSPKQIVSISTSLIPFLENDDANRALMGSNMQRQAVPVVKAEAPIVGTGVEGVAARDSGYVVLSKHRGKVVSVDGRRIIVQRIDEKGKPELDERGKPIEDVYTLHKFVRTNQDTAVNQRPIVSVGEIVQTGTPIADGPSTEMGELALGKNVLVAFMPWEGYNFEDAILVNQELLEDDTFTTIHVEMYETIARDTQLGPEEITADIPNVSKESLKNLDESGIVRIGAYVTSQDILVGKVTPKGESETTPEEKIIRSVFGDRGRDVKDSSLKLPHGVEGRVIDVKVFEKEEVSELGSGINKLVKVFVGIRKPLDVGDKLAGRHGNKGVVSNIIPKEDMPFLPDGTPIQLVLSPLGVPSRMNVGQVLETHLGWLGKLTNRYFATPIFDGATEEEIMTELYEARKRFGLEDGDSEDLKTGKVTLRDGRSGNPFDYPIVVGVMYMLKLVHIAKDKIHARSTGPYSLIHQQPLGGKAHFGGQRFGEMEVWALEAYGAAHTLNEMLTIKSDDIKGRNDVYKAILKGINIPEPGIPESFKVLIKELQGLSLDVKVFDQNNVELDVDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H9</accession>
    <name>I2F3H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730536.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0768"/>
    <dbReference type="EnsemblBacteria" id="AFK06482">
        <property type="protein sequence ID" value="AFK06482"/>
        <property type="gene ID" value="Theba_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0768"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_0"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="30730" checksum="30A2F9D2C0C56F88" modified="2012-07-11" version="1">MKISIVGNVNIDLSAFISESGNNEENRISEMSFAIGGSASNTSIMLSRLRKSIYLQGAVGSDLFGEMALELLKREGLNTDYLLKLNGKTGFCFSAISEDGQRHLFTYRGVNEKAYPIEDGFDFYHFGGVTPDQIERFIDKTGEVRFSYNPGGIVTFEKTTGVAAIAARCEVLFVNESEWNHLEHSLTGEPKEIVVTQGARGSKIKNGPEEAAFPAKVIDTTGAGDSFIAGFLHAYLSGKDPVQCLKLGNLLASMVVSRPGASPAFTYNEVSDLANMYHVYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I0</accession>
    <name>I2F3I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730537.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0769"/>
    <dbReference type="EnsemblBacteria" id="AFK06483">
        <property type="protein sequence ID" value="AFK06483"/>
        <property type="gene ID" value="Theba_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0769"/>
    <dbReference type="HOGENOM" id="CLU_813254_0_0_0"/>
    <dbReference type="OrthoDB" id="1517949at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="313" mass="35088" checksum="33CB2E076A1D54BF" modified="2012-07-11" version="1">MPAQIASVDVVRILGKLSDDGGEQSSRNRFIREYLSKYASPESIISDIEGLLEAYPTFDGDSESLGRAYADLVNRLAELSGFSVDYVKYSGREKITGIWKVGEAIQIKVAAIVCTDFEEAKGVARNALLILPEAIDLGRPFVTVGRLGMLFSMIEQIELPVSSVASILVTDDNYDKRISSFMELMLLAFKKELARKPQISLQKEWSKEELEEFIMERLKLPTIGMLFSLLDSPMLSEDLVDRINSFLEENESELVKGPMALGAIMGALSKHYSGIKEELVLREGKRYRLADKYRPLISEIKARFESGVQARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L8</accession>
    <name>I2F3L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730573.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0807"/>
    <dbReference type="EnsemblBacteria" id="AFK06521">
        <property type="protein sequence ID" value="AFK06521"/>
        <property type="gene ID" value="Theba_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0807"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_1_0_0"/>
    <dbReference type="OrthoDB" id="1777855at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="23362" checksum="C774582AF7FCA853" modified="2012-07-11" version="1">MSCKKSLLEPGHFEINVRRSRFVGDGARCECEEEAKSFIKSLSQRYANADHCCWAYRISLQGREIANYSDAGEPHGSAGKPILGAIESLELTDVVVVVTRYFGGTKLGVRGLIDAYGETAAGALRAGKPALYCPGLELVVEMTYSQWNDFIRLFGEDKDYSVRKVDYSERVFASLAVQEKNIERIMGFLEDRRIFHKSGEELSFVSPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N5</accession>
    <name>I2F3N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492526.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0824"/>
    <dbReference type="EnsemblBacteria" id="AFK06538">
        <property type="protein sequence ID" value="AFK06538"/>
        <property type="gene ID" value="Theba_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0824"/>
    <dbReference type="eggNOG" id="ENOG5032WN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173848_0_0_0"/>
    <dbReference type="OrthoDB" id="1907777at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="101" mass="11903" checksum="F1BF9F178F2BC6A1" modified="2012-07-11" version="1">MFFKKKPRDIGRNPFYDNGNTVVVHFQCNKCGEKFRSHLRKYYDVSVNYGKGKGAYRLDKEFIGSNCQNRIQITAEFNRAFKPLSFEIVGGRFISKEEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q3</accession>
    <name>I2F3Q3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730597.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0842"/>
    <dbReference type="EnsemblBacteria" id="AFK06556">
        <property type="protein sequence ID" value="AFK06556"/>
        <property type="gene ID" value="Theba_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0842"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122749_0_0_0"/>
    <dbReference type="OrthoDB" id="1613263at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="149" mass="17358" checksum="2908915717A76BA1" modified="2012-07-11" version="1">MLSPHEILELAMKIEEVGVSFYRELAENVEDENKRSLFRYLSKQEEGHVETFKFLLRKFEEESLELINWDDSEAYVEDLANGSVFSRSLHDSMSSSDYQKIISLAIEAEKKSIAFYESIQKNARFTTADALKRIIEEENNHIELLKGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T8</accession>
    <name>I2F3T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAK2 domain fusion protein YloV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730629.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0881"/>
    <dbReference type="EnsemblBacteria" id="AFK06591">
        <property type="protein sequence ID" value="AFK06591"/>
        <property type="gene ID" value="Theba_0881"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0881"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_1_0_0"/>
    <dbReference type="OrthoDB" id="1554133at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="554" mass="60980" checksum="5C1DCB1B20861460" modified="2012-07-11" version="1">MKRINGKFFVAAFRKAAERLLANKDEINALNVFPVPDGDTGSNMAAAMIEACEYLDRLKKDDLVSVLESVKTGMLMGARGNSGVILSQIFRGFAEGIGNRKFVNTKAFTEGLTKAREIAYRSVMKPVEGTMLTVMKVSADTANEEFGGIEDFDEYFEKLVEVAFDTVEKTPTLLPKLKEAGVVDSGAKGLAYIFEGFLLATKGDIELEGPLQQMPQAMGSSTERIVEIVREELKFTYCTELIVKLDESDSQEETSELLKAYLEEMGDSIVMVHQDEIIKIHVHTDHPGDVIEKFLGVGFLQKVKIDNMKVQHEHIVDIQSRGPEMFGKEKHHGVIVVSPGDGLADVLKSLGVDYAVKGGQTMNPSLKDLYEAISRIAADKVIVLPNNPNIILTAKEAANAIHDDNPGKEVYIIPTRTVQEGIAAMTVYNDEMDSESLIREMEEAAEAVSPISITYAVRDSSMKGKKIRKGEYIAIGRDGLITSGRKLEKLVHDSIKTVLGKDGDKEVVTIFYGSEVSEEAAGKLLESLSGSFSDFEFEIHSGGQPYYYYLISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U3</accession>
    <name>I2F3U3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">Theba_0886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730634.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0886"/>
    <dbReference type="EnsemblBacteria" id="AFK06596">
        <property type="protein sequence ID" value="AFK06596"/>
        <property type="gene ID" value="Theba_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0886"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_3_0"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="148" mass="17404" checksum="D2363D8276D10883" modified="2012-07-11" version="1">MKAGPNNSRRKMREIVFSAIYQFDFNEDMESSSDYLEQELSFFSMEMEMKLRTRKYFDTILKNRNEIDEIIRKHLTNWTFERLASTDKNVLRLGAYEIIYEPDIPIEVTLNESIDIAKKYGSEQGGKFVNGVLDKIARECASTEKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V3</accession>
    <name>I2F3V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730638.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0896"/>
    <dbReference type="EnsemblBacteria" id="AFK06606">
        <property type="protein sequence ID" value="AFK06606"/>
        <property type="gene ID" value="Theba_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0896"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="234" mass="25664" checksum="0788FCA393752005" modified="2012-07-11" version="1">MLKVEKLNVFYGGIHALKGISFNVEEGKIVALIGANGAGKSTTLRSVCGLKKVKDGEILFKSKNITNKSTNDIVKAGMTLVPEGRRIFPNLTVTENLMLGAFLRRDSEEIEKDLDWVNTLFPRLRERKDQKGGTLSGGEQQMLAIGRALMSRPDLLMLDEPSLGLAPVIVGEVFRVIRKVHEEGKTILLIEQNALAALKLADYAYVLETGRIVLQGKGEDLLSDDLVKKSYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W4</accession>
    <name>I2F3W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0908"/>
    <dbReference type="EnsemblBacteria" id="AFK06617">
        <property type="protein sequence ID" value="AFK06617"/>
        <property type="gene ID" value="Theba_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0908"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="223" mass="25121" checksum="65B033FA96D1728B" modified="2012-07-11" version="1">MDRIWKIVVNYWPKFLEGLGVTLEMTLIAVVIGFIIGVILAIARVYGNKLFHGVATAIIEIIRGTPLLVQLFILYYGLPPLGMNLSPFAAAIIGFAINSGCYQAEYLRGSIQSISGNQMKAARSLGMTKWQAILQIIMPQAFRRVIPAWTNEFIYLLKYTSLAYIVGAPELMAQAKFIASRNFQFFEVYLVVAVIYLVVVLFFTKIFSILEKKVEIPGLEWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X1</accession>
    <name>I2F3X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492621.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0916"/>
    <dbReference type="EnsemblBacteria" id="AFK06624">
        <property type="protein sequence ID" value="AFK06624"/>
        <property type="gene ID" value="Theba_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0916"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111226_4_0_0"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="17559" checksum="61840B9C7431410E" modified="2012-07-11" version="1" precursor="true">MEHIVRFEEITEETVLDAIRLSGTLLKGQERAVASNAVSIAQAHFAKNAWFRAIYAGDDMVGFIMLDFTPDPRMKDVKHASMWRFMIGGKYQKMGYGRDAILLLIEYLKAQGYEKLFTSCIVNDPSPLHFYLKLGFVDTGEWDDDEKILMRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F448</accession>
    <name>I2F448_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730716.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0995"/>
    <dbReference type="EnsemblBacteria" id="AFK06701">
        <property type="protein sequence ID" value="AFK06701"/>
        <property type="gene ID" value="Theba_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0995"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="278" mass="30784" checksum="EF1742E8AD0CC611" modified="2012-07-11" version="1">MKIGLVTDNTCNLTAEEIKEYDVRIVSLYISRNGNYTKATELNLDEYYEELAAAAELPRTSQPSPQDFIPVFKEALETYDALIVPVLSGKLSGTNVSANIAAKAFEKPIHVIDSQLIADGTGMLVKNLGDMINSGANLDELVEYGTNFHEKTRTFCSTDDLSYLQKGGRIGKAKALMGNLLKMKPVIIVDEGELKPVENVRGNKKLLDVLVSHVFSEIPPERLRRARVLTIWRKEDGKTLERMLREKAPEAEVESRVIEAIIGTHLGPQGIGVISEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F456</accession>
    <name>I2F456_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730720.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1004"/>
    <dbReference type="EnsemblBacteria" id="AFK06709">
        <property type="protein sequence ID" value="AFK06709"/>
        <property type="gene ID" value="Theba_1004"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1004"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047375_1_0_0"/>
    <dbReference type="OrthoDB" id="437351at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="419" mass="47593" checksum="C2E92FC605459A2F" modified="2012-07-11" version="1">MSRKSVRFGSFLRNHIDDRDSFKKWLQLGMAFENFRRKYFPDRDRPRFVNTVNHLALEEVYHAVKGEKTAWVNLMNPSELLLSAGLRPVSAEGISGALSSMHLEDTAISVSSQAGISDSLCTFHRASLGVSLRKLLPPPKLVMTTSILCDGNLPTFKRIAGEYDVPFILIDVPRGRKQEAVGYVLSQLKDVIVTIQEITGKPFKMDELSLRLSYERELINNLEKARLRAHDSYLPQHLYEHMNSLYVLHTLAGDPRIALGSRNVAESLKVIPENAKRILWLHIPPYYDNELFELFSPNSENLVVGNELMWDWIYPVDPDRPLESLAKKLVFNPLCGSVVDRGEFCLGLARDFNVDGVIHFSHWGCRQSSGGVPFLKRLFESEKIPFLELTGDCVDHSSQGAGQLRTRVEAFLEILENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N9</accession>
    <name>I2F4N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phd_YefM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06892">
        <property type="protein sequence ID" value="AFK06892"/>
        <property type="gene ID" value="Theba_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1194"/>
    <dbReference type="HOGENOM" id="CLU_2617908_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="78" mass="9055" checksum="219F69DF9458BEC0" modified="2012-07-11" version="1">MTDLSRSPGKYFRQLESSGDTLLVIKNSEIKYAVMNIETYKKLIEAEELFENSQIAEILKERAVVPKEEYLEVDIDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R2</accession>
    <name>I2F4R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1221"/>
    <dbReference type="EnsemblBacteria" id="AFK06915">
        <property type="protein sequence ID" value="AFK06915"/>
        <property type="gene ID" value="Theba_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1221"/>
    <dbReference type="HOGENOM" id="CLU_2070313_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13021" checksum="0DF050328F024F62" modified="2012-07-11" version="1">MILPLPDADTFMKDFMAISEEQIGFIVNYVEKGGLLVVVLARKEINHPSIESYKLLFEKLRWAVKLENGGRSVSGTSTGNLEIENGGGVVILSWDEATGKSAIDEETMGFIEFKLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S0</accession>
    <name>I2F4S0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486567.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1235"/>
    <dbReference type="EnsemblBacteria" id="AFK06923">
        <property type="protein sequence ID" value="AFK06923"/>
        <property type="gene ID" value="Theba_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1235"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_1_0"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="81" mass="8928" checksum="98436E0A45696BD5" modified="2012-07-11" version="1">MARKSAGRSNGRESNPKYLGIKRGESSAVKAGSIIVRQRGTKIHAGKNVGLGRDHTLFALIDGKVHFEEKNNRKYVSVYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T5</accession>
    <name>I2F4T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730919.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1250"/>
    <dbReference type="EnsemblBacteria" id="AFK06938">
        <property type="protein sequence ID" value="AFK06938"/>
        <property type="gene ID" value="Theba_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1250"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_1_0"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="565" mass="63080" checksum="D00B1D29C3A58E17" modified="2012-07-11" version="1">MLRVYKRLGELLIDQGLISEDTLQQAVSLQKKVNKPIGEVLVGMGVISWEDIYDSLSKQYGLKVLEDLPNMLSPEVLRMIPKPVADRLNVIPIEYLPENGLLRVVTTDVLKVPQIDRELSFLTGNKISTLLVPPPMFDALYRSSYEESASSEIIDNTFSIDQHSEVDLDEQKVDETDDTPVAKFINSLLDNGIRSDASDIHLEPYEKMAVARMRVDGVLRKILSYPRKAHNSVVSRIKVMSNLDISEKRMPQDGKFYIRRGNEQFDMRVSTMPTIFGEKVVMRILRVSNAKKQLEDLGLSEYNRQRFESIITSPYGIILVSGPTGSGKSTTLVAVLNQVTSDKVNVLTAEDPVEYTIEGISQCQVNTDIGLTFARYLRSFLRQDPDIIMVGEIRDRETAQLAIEASLTGHLVFSTIHTNSAAGAVARLVNMGVDPFLLGTSLIGVMGQRLVRKLCNNCKVKIPVREEVRKIASMLYPNRDDFSEYIPGNGCPECRGMGYRGRTSISEILVVDNKLRQLIGENASEREIAAAAISGGMRTLYNDGVQKVIDGITSLEEIKRVAIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U9</accession>
    <name>I2F4U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730933.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1264"/>
    <dbReference type="EnsemblBacteria" id="AFK06952">
        <property type="protein sequence ID" value="AFK06952"/>
        <property type="gene ID" value="Theba_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1264"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_0"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="142" mass="16258" checksum="79B1BA8CB1ADEEF3" modified="2012-07-11" version="1">MEIKDTVALLKSKGYRITPQRVAIIRILRDHEGHPGVEEVFRSVIQVHPNISMATVYNVMEVLEKEGIIKAIANSKKSRRYDSEVKPHGHFICNSCGRVFDIPMKYYEACLKVFPSEMTDFEVNSFELTIKGICPDCKKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W1</accession>
    <name>I2F4W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine beta-lyase/cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486627.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1276"/>
    <dbReference type="EnsemblBacteria" id="AFK06964">
        <property type="protein sequence ID" value="AFK06964"/>
        <property type="gene ID" value="Theba_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1276"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_0"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="398" mass="44368" checksum="67908BCA791E6ADF" modified="2012-07-11" version="1">MDKTKKHHFDTLSIHAAEQEDQNQSLNPPIYMTSTFTFTDLQQAEDTFSFKRRAYVYTRGGNPTINLFEQRLATLENGVDGVAFSSGMAAISSVVMSFAAAGDSLVAHRNLYGSTFGFLNHLITNYGVKTKFINMTDLNAVEKAITSETKLIYLETPTNPALEIIDIEALAKIAHSNGVKVVVDNTFATPVFQRPLDFGADVVLHSATKYISGHGDVIGGFATSKDFDYVQKLKFGYMCELGGVMSPFNAWLLLRGMKTLGLRMERHEKNAREIANFLRNRPEVVKVSYPGFEDHPGHDIASRQMEGFGGIISFELKGPRENAESFVRNLNLIKLAVSLGDAETLVEVPAMMTHRDYPEEELHEFGFSSKTVRISAGLEHYSDLLNDIENSLDKVYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X2</accession>
    <name>I2F4X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730951.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1287"/>
    <dbReference type="EnsemblBacteria" id="AFK06975">
        <property type="protein sequence ID" value="AFK06975"/>
        <property type="gene ID" value="Theba_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1287"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042763_0_0_0"/>
    <dbReference type="OrthoDB" id="1155165at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="347" mass="37144" checksum="63106B1A70F99713" modified="2012-07-11" version="1" precursor="true">MFESIANLIEKAGWPRIIIALFLLSLFVIAPFVNISIGTSISDTLVRFAMNSVLVLSLVPMVQSGCGLNFGMQLGVIAGLIGAVTSIELGVTGLAGFLTAIGIAIPFAAILGFFYGLLLNRVKGDEMVVATYVGFSSVAFMSMMWLLLPYKSPNMIWGYGGSGLRTTISVEGYWLGVLNNFLSIRIGNFFFPTGTILFFALIALLVWSFFKTKLGTAMTAAGSNPVYAKAAGVNVDRMRILSVVISTVIAAVGIIVYEQSFGFIQLYMAPLLMAFPAVAALLLGGASVSKASMGNVIIGAFLFQGILTMTPSVMNNLIKSDMSEVIRIIVSNGMIVYALTRRTKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y1</accession>
    <name>I2F4Y1_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730960.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1296"/>
    <dbReference type="EnsemblBacteria" id="AFK06984">
        <property type="protein sequence ID" value="AFK06984"/>
        <property type="gene ID" value="Theba_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1296"/>
    <dbReference type="eggNOG" id="ENOG50309QR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2031524at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="193" mass="21395" checksum="199C7610B9D30843" modified="2012-07-11" version="1">MTEKIEAYFMKEFSEKAGRIAVFSLGLLIPFYQVRMIFLFLLAMSLLPSDIQHKRLGSLLALPYSRQELFWISYLFLIAMSVVTQVIGMALFGAQLISSMNVYWLSMVIGSISFSTAYYAVSMISVTAGLDNFGIPFLVLIADLIAGGVGNRFSNPYFYASPAHEGNVWISGAVSLVVLLVANYLFVKKGVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z9</accession>
    <name>I2F4Z9_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486704.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07002">
        <property type="protein sequence ID" value="AFK07002"/>
        <property type="gene ID" value="Theba_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1314"/>
    <dbReference type="eggNOG" id="COG3461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1833195at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030907">
        <property type="entry name" value="Ferrit_encaps"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04535">
        <property type="entry name" value="ferrit_encaps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="110" mass="12595" checksum="56C47DA0E49E7CF5" modified="2012-07-11" version="1">MSSYHESVDQLSEKAKDISRALNSLKEEIEAVDWYNQRVDVTEDAELKAVMAHNRDEEIEHACMTLEWLRRNMDGWDDELKTYLFTKAPITEVEEAGSGSENSGLNIGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F505</accession>
    <name>I2F505_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730978.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1320"/>
    <dbReference type="EnsemblBacteria" id="AFK07008">
        <property type="protein sequence ID" value="AFK07008"/>
        <property type="gene ID" value="Theba_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1320"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_0"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="263" mass="30344" checksum="BAC6C3BE36D8534C" modified="2012-07-11" version="1">MVPKNWDKIRIYELSQPISHLTPPWPTYEPLQIKFFKRLAPNGANGQLLTHSNHVGTHLDGSLHFCTHGRDIASIPLNELVAPGVIVDLSDIAEDYGIYTSKDIEERVEVKEGDILIINTGYHKYAYDQPEADEVRYMIKHPGPTREFAEWCKMKKIKWIGVDCGSADHPMNTKIREWMPVQAKECDHYMHEKYGKSLEEIFPDEDYQLMHVLLFPYDIIHAENVGGEIDKILDKRMVIGCFPWRFVGGESCISRIVAFDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F527</accession>
    <name>I2F527_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486758.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1342"/>
    <dbReference type="EnsemblBacteria" id="AFK07030">
        <property type="protein sequence ID" value="AFK07030"/>
        <property type="gene ID" value="Theba_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1342"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_3_0"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="301"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="485" mass="52712" checksum="ED63E1E446EA9902" modified="2012-07-11" version="1" precursor="true">MKKVLLITLLLIMAVFVMGQKLTILHINDTHGHIWPEGDYGGLAAITTLVNQVRAENPNTLFLHAGDINTGVPESDLQDAAPDIVALNLMKLDAMAIGNHEFDNDASVLAKQMEIANFPFLSANIYKDGEPAFQEYMITEVGGIKVAIVGFTTQETEILEYLYAKDYEWKDVIEVAKEIIPELEAQADIVIALTHMGSNPVLAGPNSWELAKAVDGIDVIVDGHSHTFYERPEIINETIIVSAGEWAKNLGKLELEIVDDTVIFVSFRNLPVIAEEIEPDFAVATVLDYFKKAGGEALNIVVGETAIRLEGDRGVVRSQDTNLGYLICDAMVWKTGADLALTNSGGIRASIEAGPITYRDILTVLPFGNTLYVLEVPGTALREILQYTATREAGQGAMAQVSGVTYVIENKEAKDILVNGEPIDDNKLYKLATNNYLASGGDGYEILAGLSGYDTGFVLADVVVEFVGEISPITSYPDSGRITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F562</accession>
    <name>I2F562_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731011.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1377"/>
    <dbReference type="EnsemblBacteria" id="AFK07065">
        <property type="protein sequence ID" value="AFK07065"/>
        <property type="gene ID" value="Theba_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1377"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084710_0_0_0"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="223" mass="25369" checksum="88FE5BE1F61D56C4" modified="2012-07-11" version="1" precursor="true">MNFTKKILIFMGMFGSGKTEIALNVSRLLTKKGERVALADIDTVSPYYRSRDMRDSFEQLGIKIIAPKGKLANADLPIIPPEIFGYVENPEFRVVLDVGGSDDGAVVLSSLSSRLPYDNCETFYVLNRFRPFNDTVENAASHFFRLQEKSRMKINYLVNNTNIGPETISETIDKGEEFVKQLSEKVSVPVAFTVVMNGLNREPRLFEQLEIKKYMLNPWEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F565</accession>
    <name>I2F565_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731014.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1380"/>
    <dbReference type="EnsemblBacteria" id="AFK07068">
        <property type="protein sequence ID" value="AFK07068"/>
        <property type="gene ID" value="Theba_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1380"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_2_1_0"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="51"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="27216" checksum="B230DDC2606A8F7D" modified="2012-07-11" version="1">MEKATYKKPKSLAEKEFSYCPGCHHGIIHRLVAEVIDELDIQGKTLMVAPVGCSVFAYEFFDIDGTVAPHGRAPAVATGMKRAMPEKMVFTYQGDGDLAAIGTAEIIHAANRGEKITTIFVNNAIYGMTGGQMAPTSLLGMKTTTSPYGRKAETEGFPIHVSELLKETAGIVYLERVSVSSPQEVIKAKAAIKKAFIAQKKGLGFSLVEVLSTCPTNWGLDPIESIKWLNENMKKEYPEGVFVDKVGDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F574</accession>
    <name>I2F574_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxylamine reductase</fullName>
            <ecNumber evidence="6">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hybrid-cluster protein</fullName>
            <shortName evidence="6">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hcp</name>
        <name evidence="7" type="ORF">Theba_1389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="6">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731023.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1389"/>
    <dbReference type="EnsemblBacteria" id="AFK07077">
        <property type="protein sequence ID" value="AFK07077"/>
        <property type="gene ID" value="Theba_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1389"/>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038344_2_0_0"/>
    <dbReference type="OrthoDB" id="337713at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="6">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="6">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="552" mass="61059" checksum="B4669437BA31A12B" modified="2012-07-11" version="1">MFCFQCSESMKGTGCTVQGICGKEPEVADLQDLLIWILKGISLWGVKAQEMGVKDSETGLYVAEGLFTTITNVDFDPESLGKKIDRALNVRRRIERIFKEAYRKEKGKEFSEPMPEACTWESSRGVESYKAKGAQVGVLDTQDEDIRSLRELLTYGLKGIAAYTDHAYILKHSDNSILDFLQEALASCLNDSLTAEDYVALVLKAGEYAVKAMALLDEANTGSYGNPEITSVYTGTYEGPGILVSGHDLLDLEELLKQTEGKGINIYTHGEMLPANGYPGLKKFSHLRGNFGTSWYNQQKEFEEFKGPILMTTNCIQRPRESYKDKIFTTGLVGWPEVSHIPNRVDGKEKDFTPIIEKALEIGDIGARPGKKIVVGLAHDQLSKVSDKIIDAVKTGAIKKFVVMGGCDGHAKKRQYYTDLAERLPKDMVILTAGCAKYRYNMLDLGDIGGIPRVVDAGQCNDSYSLVVTALKLKEAFGLEDINDLPIEYDIAWYEQKAVAVLLALLYMGVKGIRLGPVLPAFISPNVLKVLVENFDIKPIRTVEEDLSEIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A2</accession>
    <name>I2F5A2_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731050.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1419"/>
    <dbReference type="EnsemblBacteria" id="AFK07105">
        <property type="protein sequence ID" value="AFK07105"/>
        <property type="gene ID" value="Theba_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1419"/>
    <dbReference type="eggNOG" id="ENOG5032STI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320507_0_0_0"/>
    <dbReference type="OrthoDB" id="744805at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="905" mass="101040" checksum="93B4CA4D64B611A0" modified="2012-07-11" version="1" precursor="true">MRKGLVLPLTLIIMMSVTVISVALLNRTSSTTSELFQRISKAQLQVNGGNAFFANFGYLKRKFAEESYLNLSTDNFYMSLTSTPTMYEDFLGLFASDTLEYLAWKDLFSKFSDERFYKPGFDLTKVFDEVTGGTFDDMVLIPYKSSPNTLLAIVRTSKGNMSAYFWGLASPRFFSNWSRFELESNSTAFWYPGSVIYGPTFFGSVGQGGAGNGGFRMKATIPPDPDDVSGDGPIFNGEVWCENANIDLALQGDWEGRKTIRVDTDGDGDFDDERFNNKYYAVHVENGETWVFLEGFNEVIVADSYEEVQGEMRVKGSVIDFVDNASSGDFNSRFLPWFLRAGSIKVSQETIVDLETRFDEMEEYYQSHYSNTTSLEDMLNAIEMGSVLPQNSLGLYLKDTERSSGSQVTETETLQQIRYEDTQWLEALLINSNEFLDELEAWIIDDDHRKLSANSILGKNDNITDDSFTYEELREIISSDHVTLSEFESPIIEERRSIVQVETTGNLSILDMASNVTISSDVLLGSSLNNLVGSGAFESSSSFSVISYQWDREVRSSSGSQQIRERTRVANRYPMEYEMSTVVFSLNFTGWEWRFTGKSGPSQKGPRSWSHNSSIEGPVAIAVWSDWSYSQWSDWDVIGGGGSGQKIADADVDMYLITPSDGFSEMNFDTTVIMKVNSHDEDDYPSFTTEATSFSNKGYYVVEEDIETGGAGIPGGVGTTLGREATVIDGRYTIRSKEGDIRIYGDVLYNDMLNDSTFRSYVDESGLAFDSNYNPNLSAANASLNDMLNLVATNGNIVMPYQSSSSGRDAIKNIKLFTNLFAFGKNSGHSNTGQILIDDYDRYNVDMGFRHLFGTMVSIEAGPAGTTSGGFKSRNYYDERLYGNEDLPFASPESNILEVMGTSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C5</accession>
    <name>I2F5C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486965.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1442"/>
    <dbReference type="EnsemblBacteria" id="AFK07128">
        <property type="protein sequence ID" value="AFK07128"/>
        <property type="gene ID" value="Theba_1442"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1442"/>
    <dbReference type="eggNOG" id="COG1480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015767_4_1_0"/>
    <dbReference type="OrthoDB" id="1124669at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="261"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="497" mass="56073" checksum="1E7A910089EE8ECB" modified="2012-07-11" version="1">MNMREKKKLKKSDLSKVQFPLERLLNIKDLTNFIVFPVFLALLNRLPFLSLPSKPFLYFVGSAILWYIFAERSVRSNRYFNLHSAYRITFFSVVSFGVFVNSFVPSLGDETLLPEMTPIFLSVSMVTILIGYQEGIGSGLFMSFLASANLDNSLETFILLSVVVLATALTTRAIERRIEIARAGFEVSLIFVAINAIRMSLQGESINAVDLLIAFANPILSSVIAIGIIPYLEYASRIYSNTGLLELGNLSHPLLKNLSIYAPGTYYHSISLANLSEAAAERIGANAILARVASYFHDIGKSKRPQYFAENQQEGMNPHDNLTPSMSNLVINEHVKQGVEQARKYRLPLLVEDVIKEHHGTRVKKFFFHKAKNIGQEERSDDFRYPGPKPQFKESGIIMLADSVEAAFKSIKKPTPAKTQELVEEIVNGIYNERQLDQSGLDLDDLEKIIEAFTRVLMNMNQPRIEYPKETTEKVVSINGDSNSKQDIEEDRREQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F9</accession>
    <name>I2F5F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative AP superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731095.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1479"/>
    <dbReference type="EnsemblBacteria" id="AFK07162">
        <property type="protein sequence ID" value="AFK07162"/>
        <property type="gene ID" value="Theba_1479"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1479"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039939_1_0_0"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="394" mass="44533" checksum="BB9914A12117B231" modified="2012-07-11" version="1">MELNFPRYDGSSIVNFSAAILEHFDADIPQGVKAYSLKDNGLSLEGIDKVVVFIIDAVGYYNLIKVLEKKSFKYFDQKDIRILTSVFPSTTATALTSIFTATPPGEHGVLGYLLNVPEYGGLVNMIELAPYTQDRDNLTRLGFDPLKYNPNPTIFELLKEVGVRGYHLTSKSFVNTGLTRMHSRGGIARGVHGLGDMFEELRTALFSEEAASVTLVYWGLIDTYGHRYGPNSLSYTSETATVISAIEEFFEDIAERNTAFFITADHGQIETPWEQEIWWSKFDDLFEEMYSMPGGEQRMSYIYSYDGEKTKRKMERQFGDALEIIEPSGLDEIKLFGKPLNSVFRKRRGELITVSKGNSSLCFKYTGQEHSLKGRHGGLTKEEMYVPLILLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H0</accession>
    <name>I2F5H0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4">6.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Theba_1491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731103.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1491"/>
    <dbReference type="EnsemblBacteria" id="AFK07173">
        <property type="protein sequence ID" value="AFK07173"/>
        <property type="gene ID" value="Theba_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1491"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_0"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="13">
        <location>
            <begin position="105"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="12">
        <location>
            <begin position="310"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK07173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="447" mass="50480" checksum="4A70F877DCBD0C65" modified="2012-07-11" version="1" precursor="true">MKYHFIGIGGIGMSGLAMHLASEGDQVYGSNYEENERVAYLRGKGIGVFIGHSYENFEKPDVVVRTTAIKQGNPELERAIFESVPTIYRMELLKSLLLRDTSVCITGTDGKTTTTAMVSKILIDSGRDPTVFLGGINPILKDGNYRKGKDLIVSELDESDGFFASFKPDYAVITNVRGDHLEHYDNSFDNLKNHFRYFSRSVGKLLVTNADDPASERIFTDTLTFGKDRGYYRFTDRSTGIMNQTFRCFRGNEDLGLFKLMIPGEFNVYNATAAIALTHEMGVPIESIKNSLESYRSVDRRFTFRGLDDFRNLFFFDDYAHTPDEISNTIRGAREFFPGKNVIVVFQPHRYSRLVRENGRFANSLKDATEVCVFKLYEAYEKGQYAIDETEVLKGLSSYGVPAVHAVNYSEILEWLEKKRDAVILFLGAGDITEASKMSVLKLCEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J1</accession>
    <name>I2F5J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein HS6-type (S12/L30/L7a)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487088.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1512"/>
    <dbReference type="EnsemblBacteria" id="AFK07194">
        <property type="protein sequence ID" value="AFK07194"/>
        <property type="gene ID" value="Theba_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1512"/>
    <dbReference type="eggNOG" id="COG1358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157804_2_0_0"/>
    <dbReference type="OrthoDB" id="2066583at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="108" mass="11864" checksum="00D59A8C2473D830" modified="2012-07-11" version="1">MDEKRVLSLLGIGRRANKVVFGKEQLRSYLRQPFKRKSLILASDTSDSIKEDWVKRCKSHGASCILLKEHDRVALGRAIGKDNISAVAIADDGLADEISKIITQAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L5</accession>
    <name>I2F5L5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">Theba_1542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731130.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1542"/>
    <dbReference type="EnsemblBacteria" id="AFK07218">
        <property type="protein sequence ID" value="AFK07218"/>
        <property type="gene ID" value="Theba_1542"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1542"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_0"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="214"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="33666" checksum="5784C321C49C1B2A" modified="2012-07-11" version="1">MNIVFMGTPEFAASHLKALVESGVKVIGVFSQPDRPKGRGRRVYPTPVKSVAEVYGLPVFQPEKVNSGEGLEKLKELSPDLIVVVAYGKLLKSSVIDLPTLGCFNVHASLLPKYRGAAPIQRAIENGETRTGITIFKIDEGMDTGEIALRREIEIEISDNFGSLYEKLERLGREALLDFLKIAEAGRIELCKQEGAPSYAPKVQASDLVISDFSDAVYVLNKVRAYDPQPGARTSLDGKMVKLFGAAFSDRSYGKSRDGEIVKVEDHGMVLSCGTGNVIISLVQLPGKRPMSPKDAVSGWLIREGMILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q7</accession>
    <name>I2F5Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489375.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1592"/>
    <dbReference type="EnsemblBacteria" id="AFK07260">
        <property type="protein sequence ID" value="AFK07260"/>
        <property type="gene ID" value="Theba_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1592"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="274" mass="31134" checksum="EB0802F584CFD4CA" modified="2012-07-11" version="1" precursor="true">MKTRIVKGILRYVLLVALAMFFLFPIYWMFVSSLKSPSEIFAFPPKLIPENPVWSNYSKVFSQVPFARYMLNTFFVASVVTIVALLLHSMAAYSLARLRYPGRNVLFILVISTLMIPFSAILIPLFLIVKNFGWIDSYRGLIIPAIPHAFGIFFLRQFYLGFPRELEEAAIIDGSGLVRVFFKIVLPLSKPVLSALAVFFFLANWNSFMWPLVIINSPEMRTVQLGIAQYGGEYNNPWAIQLAACTVALIPTLIVFVILQKQLMQSIKMTGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R4</accession>
    <name>I2F5R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731166.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07267">
        <property type="protein sequence ID" value="AFK07267"/>
        <property type="gene ID" value="Theba_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1603"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48618" checksum="F45507586B84CBB2" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWRYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFIQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLKLHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTFRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSQLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R7</accession>
    <name>I2F5R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731169.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1606"/>
    <dbReference type="EnsemblBacteria" id="AFK07270">
        <property type="protein sequence ID" value="AFK07270"/>
        <property type="gene ID" value="Theba_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1606"/>
    <dbReference type="eggNOG" id="COG1861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286944_0_0_0"/>
    <dbReference type="OrthoDB" id="1919362at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1075" mass="125110" checksum="61DE28FFE8364906" modified="2012-07-11" version="1">MSEKLEKEEKFLLDRTSHEKAIAAFKEEAERKTGIIQWYIMREENEEERVRLEIVPEKTGMRHVWTQTYKKRSSDSKDRIEREYSLDPTEVDLKNLETLPFVVKIRHYLEPKNKGIKEVILDEFLEKWKCDCQYLVEIEMNDGKEDRSIISEEASSWKFLKDLTGLTEEESKKYENKTLAKHHEESSAFKIIQYVENRLKPEQVVVALQGNSFFNKLGNLRNEYEREGFRKEKEYSVLRYKKKYNDDEELSCDLNEVLKNPCSYNDIRFLAAETDSIQHILNTGYSISDVEYIVFPDRPEGFSREDEPAIYGFLKALTENAFSKYGIDVHKRPMYYTGDNIESLSRAFTEIWKILDRIREEYPNKEILIDVTGGQKYPGIMASLYCIFNNLPFFYIFEGEVSLAKFPPVPASWDFGAIDEALAAFNSILIRNTTHSFERNHLKYSEYCSLPETFRNLYTASSNEDYLTSSLPLNVIESKYRKARGLPFGYGEDFLKLLDNDYSCTENYKNYLRKMIREVWSLQWIGDQIPETVEHSQRHSKRLMEFTVNLINTIGEENFLNGIPKQLRNEFYFVLAIAMNVHDLGHTKLTYELGDGRILPLDSLPCVVRDLHHELSYQMLEDDDRFRLFDDKQNSFDTDSCNKNTWDNIKTAVKLVTRYHREYMPITGKPGKLKDIVRMLSMEPEPLDKVVAASFADENWQKLTIMAARWLKFIDGTDVQSDRTVEPNYFKTRVLRTITEIEALAVELESNTEISPFIRNEVSDLVSEVGKLRASFEASEYKSMNRDLAISISNKASELEKNTLYPMIRKRIDECKGTITMPNWLKLLSKISFKAVQFPHFEKHNMVNYVYPRFFMEKSLFGNTDGTLRLSINIERESKNDMNSLIRIIDSVKKDIVKEFVRAGLNQFAIKTIKMEVTPLTEKILLTPLGTSPGVLYTLIKRLNPDRVIVITSQAGKDNIPEICMKAGFDIEKISTYLFNDPFTGFEEVQDIMRRMSSDFPVDIRSRITVNLAGGTSFLQYVTGEFAEVLESKMLDVTRVFAVDRRGIDAQKKEPYVVGDVVELPESKSWADKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5V2</accession>
    <name>I2F5V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1642</name>
        <name evidence="8" type="ORF">Theba_1719</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
            <strain evidence="7">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489299.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1642"/>
    <dbReference type="EnsemblBacteria" id="AFK07305">
        <property type="protein sequence ID" value="AFK07305"/>
        <property type="gene ID" value="Theba_1642"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07376">
        <property type="protein sequence ID" value="AFK07376"/>
        <property type="gene ID" value="Theba_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1642"/>
    <dbReference type="KEGG" id="mpg:Theba_1719"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="31078" checksum="79792C4A2782EF42" modified="2012-07-11" version="1" precursor="true">MKTKNEFLYFALRNGRLKVGFFILVIFILLAIFGPLFAKYGPLDYAGPGYHPPSKEFWLGTTTFGQDVFSQTVYGLRSTFLVGLVAGGLATLLGVLIGFVAGYHGGMIDELLNMLTNVVTVIPTLALLLIVAAYLPYRGILVQSIFIGLTSWPWAARAIRAQTFTLRTRDFVDLARITGMKPMRIIFGEIAPNMMSYLFMTFILQFGGAILAAVTLDFIGLGPTQGISLGLMMQNAVLWSAIQLGMWWWLIPPGVAITAIVGALYFMNTGLDEVFNPKLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5W0</accession>
    <name>I2F5W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1650</name>
        <name evidence="6" type="ORF">Theba_1727</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
            <strain evidence="5">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731208.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1650"/>
    <dbReference type="EnsemblBacteria" id="AFK07313">
        <property type="protein sequence ID" value="AFK07313"/>
        <property type="gene ID" value="Theba_1650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07384">
        <property type="protein sequence ID" value="AFK07384"/>
        <property type="gene ID" value="Theba_1727"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1650"/>
    <dbReference type="KEGG" id="mpg:Theba_1727"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="327" mass="36653" checksum="B1A65730A45D57CB" modified="2012-07-11" version="1" precursor="true">MNINISKIAKMARVSTATVSRVINNPEKVSAKTRERVESVISKLGYVPNQQARSLRSQQTKMIAIIVPHSADYLFTYPYFSIFLRETSLELSRLGYHLILTTDEPHNSVIDTYRVFTDKRLVDGFVVLDLKNEDERVDFLKLRNIPFVAVGRNEKDKDISFVDTDNEGGAYLAGKHLARKGCSHVLFINGPADQSVSLWRERGFQKAAQEMNFTFLGRNGDFVEKSGFEITKKHLGQFDGIFAASDLMAIGALKALREEGVSLPVVGFDDIPISSDVSPSLTTIHQPIDEVGRRAAINLIRLISEDHTETTILPVELIVRESSEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Y0</accession>
    <name>I2F5Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731228.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07333">
        <property type="protein sequence ID" value="AFK07333"/>
        <property type="gene ID" value="Theba_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1671"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48654" checksum="4EE1FF9BE40DD393" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWRYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIGRWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLKLHPEKTRIVYCKDDKRKDEYPNTSFDFLGYTFRVRSCKDRNGRIFYGFNPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRKFEMYTVLSRLHKALVQWVRNKYKKRRGRTKAGKWLEALARREPHLFVHWTMGIFYMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F662</accession>
    <name>I2F662_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1692</name>
        <name evidence="3" type="ORF">Theba_1759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731246.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07352">
        <property type="protein sequence ID" value="AFK07352"/>
        <property type="gene ID" value="Theba_1692"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07415">
        <property type="protein sequence ID" value="AFK07415"/>
        <property type="gene ID" value="Theba_1759"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1692"/>
    <dbReference type="KEGG" id="mpg:Theba_1759"/>
    <dbReference type="HOGENOM" id="CLU_2585596_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="80" mass="8838" checksum="39A98B825B2D1AFA" modified="2012-07-11" version="1" precursor="true">MRKLINRILLAVALSPLVPAIVTLFPWEASKPNCVGYYSVCSFAPYSSIILAGIAFATLGLVIATKRLLKRFLRLSDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B8</accession>
    <name>I2F6B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731297.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1820"/>
    <dbReference type="EnsemblBacteria" id="AFK07471">
        <property type="protein sequence ID" value="AFK07471"/>
        <property type="gene ID" value="Theba_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1820"/>
    <dbReference type="HOGENOM" id="CLU_1946271_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="129" mass="14414" checksum="49534A18DE685B9E" modified="2012-07-11" version="1" precursor="true">MTLIDVGRFFTILGIIGLVILTLCLAGFDGYESKTLYARDSGNSFATVSLRPGQQLIARMDKKVMIGNNAYLVVERDGKEVASLADDWEETKNELIFEGDGEYNLKVIFEDSSADRRSAEIEIKWLIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C5</accession>
    <name>I2F6C5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731302.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1827"/>
    <dbReference type="EnsemblBacteria" id="AFK07478">
        <property type="protein sequence ID" value="AFK07478"/>
        <property type="gene ID" value="Theba_1827"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1827"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_0"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="4">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="260" mass="29194" checksum="CC0BBBFC687FAC6A" modified="2012-07-11" version="1">MKLCIIGHPVSHSLSPAIYGRFFERMGIDATYEAVDILPDEFAEEITSVAEHFDGFNVTIPFKEKIIAHVVSQVEPPLSAINCVFERRGYNTDWVGFGKPLLERSIEEPVMIIGAGGAARAVIFFLRKAGVKRIELLNRTLSRAEKIKEEFEILGRFEISVFPFESIREVASRSMSIVNASSLGMNGEETGITSKELVGKSLVYDLIYWKTPLIELSHNCGVETVLDGRDMLLHQALENLKIWGLPSGDVFEKTFWEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D6</accession>
    <name>I2F6D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731307.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1838"/>
    <dbReference type="EnsemblBacteria" id="AFK07489">
        <property type="protein sequence ID" value="AFK07489"/>
        <property type="gene ID" value="Theba_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1838"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_0"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="643"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="717" mass="80951" checksum="D46AD0E3D5CB49C3" modified="2012-07-11" version="1">MNEIVTDIANSLSLPRWKVESAVELLEEGKTIPFIARYRKEKTGELNEIQLREISDALEYAKKLRSRKEEVLRIIEEKGKLTEELKAAINDAKNLQLVEDLYLPFKSKKKTRADKAREKGLQPLADFLKTSRIKDETFIVTFVNTEQEIFQIEEALEGARDILAEEFSLEISVRERLRNQLKEKGTIRSSHSDKQDEREVYRDYYDFSQPISRLAAHQIMALFRGEREEILSLKLELPFDILPSLRDSIGWKEYLAYYEELVEASSDSYSRLLMPSIEREVRNMIREEAEGRAIHVFARNLRHLFLQPPLGEKVVMGIDPGYRTGCKVAVIGKDGSLLYHDVIYPTPPQNDYINSSMKVVQAIKTLEVELISIGNGTGSRETEVFVSRLIKEHKLPVKYMIVTESGASVYSASKVAIEEFPNEDVTTRGAISIARRVQDPMAEYVKIPPEAIGVGMYQHDVNQSELKKTLDREVESVVNLVGVSLNTASEHLLKYISGLNSRAALNIVKHRAENGGFRNRKELLKVSGLGPKAFEQAAGFCRIINGSEALDGTSVHPESYEIARVILKSAGFNPEELFTRKEEVSAKLDGIDLDAFSKDKGFNPITVREVVGMLKKPGLDPREELEKPILRTDVLSMEDLSTGMELEGTVRNVVDFGAFVDIGVKQDGLIHKSKMGRRVRDPLEVLSVGQIVKVRVLEVDTKRMRIGLELLSNASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F2</accession>
    <name>I2F6F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1855"/>
    <dbReference type="EnsemblBacteria" id="AFK07505">
        <property type="protein sequence ID" value="AFK07505"/>
        <property type="gene ID" value="Theba_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1855"/>
    <dbReference type="HOGENOM" id="CLU_1914599_0_0_0"/>
    <dbReference type="OrthoDB" id="1836278at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="132" mass="15494" checksum="57E5295D25C9B1F5" modified="2012-07-11" version="1">MSAREVLKAFFESYRNQDFESLKSLCTDNITYINPEGLSSNGIDEFLQLLKREFESFGVLFEPISWESSVERPSFCYFSWKRGVKFARKAALRRVETFGSAFLLKVEKKWQLVHFQQAFSGSYASLFRTREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H7</accession>
    <name>I2F6H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1880"/>
    <dbReference type="EnsemblBacteria" id="AFK07530">
        <property type="protein sequence ID" value="AFK07530"/>
        <property type="gene ID" value="Theba_1880"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1880"/>
    <dbReference type="eggNOG" id="COG4635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108839_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="184" mass="20856" checksum="53D7D2EDFB30DA8F" modified="2012-07-11" version="1">MSKTVVLYKTRYGSSKKYAEWIAEELHGDLFDIEDVDPERLKDYDCIVFGGSLYATGISGLSTIKENFKSFENKKVIIFSVGASPARSEVIEDIKAKNFSPEIVEKIEFFHLRGGFDFKRLRLVDKILMILLKSKLKGKKRRGEELSDDERGMLAAYSTAVDFTSRKAIEPILESISKFTHGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I4</accession>
    <name>I2F6I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="10" type="ORF">Theba_1889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731339.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1889"/>
    <dbReference type="EnsemblBacteria" id="AFK07537">
        <property type="protein sequence ID" value="AFK07537"/>
        <property type="gene ID" value="Theba_1889"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1889"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_0"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="174"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="48594" checksum="BF0C1C38959893F5" modified="2012-07-11" version="1">MIDVRLIRENPEIVRRALECRQMTSELLDEIVYLESKRREALQVVEQKKAERNSISSEIARAKASKDVSLSLSLMERAKEISSEVKELDLQTSQIEEELKKKLLYLPNIPSSTTPVGKSEEDNVVIRMWGEPRKVDFEIRPHWDYGPETGLIDFERAAKISGARFTILRRDFARLERAIANFMLDLHHSKGYEEVALPFMVKRDTMQATGQLPKFEEEAYRIDPDDMFMIPTAEVPLVSQHMDEILEGDLPKKYTAYSACFRREAGSYGKDVRGMIRVHQFDKVELVWFTHPDDSYDALENLTADAEDVLRKLELPYRVVSLCTGDIGFAAAKTYDLEVWLPSYNTYREISSCSNVEDFQPRRANIRFRDVDNKLKFVHCLNGSGLAVGRTLVAIVENYQRRDGKIDVPKALVPYMRQEVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J6</accession>
    <name>I2F6J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731351.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1901"/>
    <dbReference type="EnsemblBacteria" id="AFK07549">
        <property type="protein sequence ID" value="AFK07549"/>
        <property type="gene ID" value="Theba_1901"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1901"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_0"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="212" mass="23876" checksum="B05C41C9678CB020" modified="2012-07-11" version="1" precursor="true">MSEELTKKAIIEALIFSARSGIEPSRIAAITGMKLNQVMLLLEELEREYGGHEHGVMIKSVNGKLRFYTKASIQSFVSQISVRPLVSITDTQMESLAIVAVKGPLTRNDVELIRGRSSQGQLLELSKMGLISKRKSRLPGRPYLYKVTSRFYELFQVDDLKEIVNGLAFSKEEDDLETSRDNLSDNEHVEEKVDSSDSGRESESERPDRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K5</accession>
    <name>I2F6K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1910"/>
    <dbReference type="EnsemblBacteria" id="AFK07558">
        <property type="protein sequence ID" value="AFK07558"/>
        <property type="gene ID" value="Theba_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1910"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384914_0_0_0"/>
    <dbReference type="OrthoDB" id="568106at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="771" mass="84606" checksum="C458021EDF36FBB9" modified="2012-07-11" version="1" precursor="true">MKRALIILVLLISLMLLGIEVQINLDHLEFLRDHFVVEGESVIGYWIYADRLPDGNYRHADAQGEGVTCVDDVARAAVLYLRLFEISGMEQHYDRAKEALEFVLSMQDSDGDFYNFVFEDGSINRNGPTSRKGGNWWAARALYALAKGARVSQNLDPEFSMRLADAAQRCFRKIIGFERDGLIQGYTDLSSVVLLGAAELYSMSNDVLLGGFIKRCAAALQSKVIQNEDSIFNGLVDESSPSEPRYFWHGWGSRQLEALAVAGEILGDDSLLEISTESFKQSSLLLINAGPLYSISSYLQLFPQIAYAAESAISAGFRLYHLTGDRDIAAITALLGSWFLGVNKLNQSMVGKNGEGFDGLEFSHVNKNAGAESTISMLLSLERIKRLPEEYGDLFSAAIEVLTPVVVLEAESMRAGLSESEIIQSTGVSGSAVTKISGAFSLRQPVTLVEASYSVFAAINEARTNEVVFTLRLGESKSEKTVKIEEKTVQKLGVLKGNGKETTLTVGGKLSEGSFDIDQIILVPDIVAVYLVEDDVSIVFNFKGCSEFDEGVSVIDGRVFEREKSVLQVPVLPVSLIEMNGFVHLDLLKYFDNNGIATSDERKTANFDNPQGLFGASYISSELEKAIDSGSLAVEDTEFMVNVDGNDNFRLTGQALTFSAEMFDKICILGAANHGDYTGEALLIYEDDSQQVIPLSFSDWCGGPSTGEKIAFEFSGRYDNTGNTERIKCMLYYRCVDLLEKPLKGIVLPQMPNVHVFAISLSRAEPGSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M5</accession>
    <name>I2F6M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multimeric flavodoxin WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731380.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1932"/>
    <dbReference type="EnsemblBacteria" id="AFK07578">
        <property type="protein sequence ID" value="AFK07578"/>
        <property type="gene ID" value="Theba_1932"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1932"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_3_3_0"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="191" mass="21016" checksum="879286208F8B9303" modified="2012-07-11" version="1">MKVVAFNGSPRVDGNTSKMIEEVFTVLNDGGIDTEIVQIGGNPVMGCTACNICFETKNRRCAIVDDYVNGCIEKMLEADGIIFGTPTYFADLSPEVKALIDRAGMVALANNAMFKKKVGAAVVAVRRGGSVHAFDSINHFFLISQMIIPGSSYWNLSLAWRKGDFEKDKEGIRTMRVLGENMAWLLRKINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N0</accession>
    <name>I2F6N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type metal ion transport system, periplasmic component/surface adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731385.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1938"/>
    <dbReference type="EnsemblBacteria" id="AFK07583">
        <property type="protein sequence ID" value="AFK07583"/>
        <property type="gene ID" value="Theba_1938"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1938"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_0"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="33233" checksum="AAEB89176915315D" modified="2012-07-11" version="1" precursor="true">MKKRTLLTITALMILFSTTLLPLRIVATINPYYLIVKEIAGKNGQVDLLIGPGQNPHIFSPKISDVRKLNEADLVIANGLNLESFLESYLEDLAAQGKRVLYMGNQLPDDFLVSEDEIGEANTDLHHFNPHIWLDPVILSDYLIPVIVEELSNIDPVNSVFYKVNAEKLISELHDFDEKASSYLERFRGSIVIVAHPSFTYFFRRYGIELEPVLEGVGDEPSIGEIKELVDFVREKDVIGIFAEYQHSKRAIDILKSETAVGHGELDSLGLSMESIIELLQWNLDEMMRVFDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N1</accession>
    <name>I2F6N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of Mn/Zn ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731386.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1939"/>
    <dbReference type="EnsemblBacteria" id="AFK07584">
        <property type="protein sequence ID" value="AFK07584"/>
        <property type="gene ID" value="Theba_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1939"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="246" mass="27669" checksum="6C755FB3F2F84E47" modified="2012-07-11" version="1" precursor="true">MENKILSVENLSYRIGSHWILRDVSFSISRKEFVGIIGPNGAGKTTLIKAIVGDLEVYSGKIVVSGKIGYLSQNPDRKRDFPIKVREVAAMGLYGDRGILRPFRKSDWIRVDDLLRTVGILDLRDRKAGTLSGGEYQRLMLARALASDPDLLILDEPEAGVDEMGKASFYRLLESLKNEKSIGILMVSHDIGMVFDACDTVMCINKTLHCYNDADSITPEELQSAFSSDLDFFIRSRDHFEREHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R8</accession>
    <name>I2F6R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1978"/>
    <dbReference type="EnsemblBacteria" id="AFK07621">
        <property type="protein sequence ID" value="AFK07621"/>
        <property type="gene ID" value="Theba_1978"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1978"/>
    <dbReference type="HOGENOM" id="CLU_212092_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="50" mass="5940" checksum="A79EE004F4D53445" modified="2012-07-11" version="1" precursor="true">MTLIMFLYYVMTAYVVGMLIWNFIKTKDINSEILYALALLPLILRLLIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S1</accession>
    <name>I2F6S1_9BACT</name>
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            <fullName evidence="1">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="219" mass="24985" checksum="C98BA0B6336E349D" modified="2012-07-11" version="1">MYDYVIWDFGGTLFDTYPAAAKVFQEVLEKYDVKASIDEILEKLKESTSKAASYFVNKYKLKNGFLEDFYRIENLLQPEKQPPFDNAKEICVKINRNGGSNFLFSHRSNYSMTKLLNYYNMLDLFSEIVSADSGFARKPDPQAIMYIIDKYGLERERVLTIGDREIDIEAGKRAGIATCLFNPDKDFVKTSADFVLTSLSQVPSVLQVCNRFSGCEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S7</accession>
    <name>I2F6S7_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Theba_1987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF1848"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08902">
        <property type="entry name" value="DUF1848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="35059" checksum="2A3B3269C0BB817E" modified="2012-07-11" version="1">MIISASRRTDIPAFYSDWIIERIRSGFALVRNPFNPRQVSKVTLNPEAVDSLVFWTKDPKNMLDKLSYLKDYCYYFQFTITPYDRSVEPGLRDKGNIIETFKKLADRIGRERVIWRYDPIIVSEQFNLAYHFRAFEKMVDLLQGHTEKCVISFLDYYKKISSGLRRLGLRRPERDEIRDVVRFFAGKAKDAGIRIETCSEEEDLDEFGITHGSCIDGNLINRLTGRNKQYSKDRYQRSACRCVESVDIGSYNTCLHRCSYCYANFSQKMIYRNYGRYDSKSPILCSRLDAGDTITERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V0</accession>
    <name>I2F6V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2010"/>
    <dbReference type="EnsemblBacteria" id="AFK07653">
        <property type="protein sequence ID" value="AFK07653"/>
        <property type="gene ID" value="Theba_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2010"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_2_0_0"/>
    <dbReference type="OrthoDB" id="728505at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="33015" checksum="6558605611D79E4B" modified="2012-07-11" version="1" precursor="true">MMSYLYAMILSALLCFIFGKIGMRLGLVDKPSGVLKPHERPITFMGGTGIFLAMIPWFFRNPEFFLPILIMWALGFVDDIRGVSPKIRLILEILVGFAVSFIIFGFSTLDSIVLSVVFAGMVNAYNMVDGLDGISSANVIVFAVFAYFTGFVPEIALAIAGVYSGYLIFNFPPARLFMGDQGSYIAGSFVGILLIQSWGTQNFIRIAAICWPVFLDLFVGFLRRSLAKKSPFAGDRDHYYDKIFRLTKNKKRVTLLISTGIALSYAFVGVFIPVIFIPPVLLAASLVQIFSLGSLHSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W7</accession>
    <name>I2F6W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2027"/>
    <dbReference type="EnsemblBacteria" id="AFK07670">
        <property type="protein sequence ID" value="AFK07670"/>
        <property type="gene ID" value="Theba_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2027"/>
    <dbReference type="HOGENOM" id="CLU_3404328_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="30" mass="3546" checksum="CC70090906B61A99" modified="2012-07-11" version="1">MRKVKDPASIERAIRKFKEKLAGESFPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F728</accession>
    <name>I2F728_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2097"/>
    <dbReference type="EnsemblBacteria" id="AFK07731">
        <property type="protein sequence ID" value="AFK07731"/>
        <property type="gene ID" value="Theba_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2097"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="321" mass="33240" checksum="1A92B20A002FDB7F" modified="2012-07-11" version="1" precursor="true">MENETEKNDRSAFVNKFLRLLKGELGLILILVALMVVFSLMSPYFFTSRNLLNITRQVSITLIVAIGMTFVILTGEIDLSVGSSAALVGVATAAVLNATGSIFLGLIAGLILGVGIGFANGVLTVYGRVQSFIVTLAMMGIARGAALVWTGGKPISRLPVDFAIMGAGYLGPVPVSTIIAAGVFILAFFVLNRTKHGVYVKSIGANREAARLSAIPVRKYRVLAFVISGLMSALGGILITSKLLSAQPTAAEGLEMNVIAAVILGGASLSGGVGTVLGTLLGAMVIGVIDNGMNLVGVSSFFQQIVKGVIILVAVLAKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F787</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.88" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2157"/>
    <dbReference type="EnsemblBacteria" id="AFK07790">
        <property type="protein sequence ID" value="AFK07790"/>
        <property type="gene ID" value="Theba_2157"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07124">
        <property type="entry name" value="ALDH_PutA-P5CDH-RocA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01237">
        <property type="entry name" value="D1pyr5carbox2"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="56"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="523" mass="57506" checksum="FF67DCF91AE8990C" modified="2012-07-11" version="1">MFDVTDFQIIPPFKNEPYIDPSDPEVRSQMMLAFERIRSHERNYDLFIGGRYLSTESKIVSKNPADPDEVVGTVSKATREIVDKAIDAAYFAFKSWSRMPASERVVPFLKAAQIMRDRRYELDATMILEVGKSWIEADADLAEAIDFLEYYSREALRYGQSQPVVQIPGEYNELRYIPLGVGVVIPPWNFPSAIMAGMTTAAAVSGNCVLLKPASDAPVIAAKFVDILREAGLPDGVVNYVPGSGSEIGDYLVEHPLTRFVSFTGSKEVGLRINELAAKHQKGQKWIKRVILEMGGKDCVVVDETADTDAASTGAVASAFGFQGQKCSAGSRIIVVREVYDEMVKLVKQKTEALTIGDTTDPNIYMGPVINESAVSKILRYIELGKKESKLITGGNRLKRRGYFIEPTVFADASPTAAIAQEEIFGPVTAIIEARDFDHAIAIANGTEYGLTGAFYSKRRDRIEKAKTEIHVGNLYFNRKCTGALVGVQPFGGFNLSGTDSKAGGRDYLLLFLQGKSISEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A6</accession>
    <name>I2F7A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2176"/>
    <dbReference type="EnsemblBacteria" id="AFK07809">
        <property type="protein sequence ID" value="AFK07809"/>
        <property type="gene ID" value="Theba_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2176"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="232" mass="25833" checksum="9DC94770D277FC2C" modified="2012-07-11" version="1">MAFVEVRDLSKTYRSGEVSVEALKGVSFDIYEGEILAILGPSGCGKSTLLNCLSGIDTPTEGKVTVKGVDLHSLKDDEKTRFRAMNMGFVFQFYNLIPVLKAVENVELAMLTMGSNEKKAREAAMEILAKVNLREREHYLPSRLSGGERQRVSIARALVHRPAIVWADEPTGALDTKTSNDLMNLITELNETFNQTFVIVTHDERVSAFSNRVLHMDSGSILKIEENKELKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B4</accession>
    <name>I2F7B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731582.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2184"/>
    <dbReference type="EnsemblBacteria" id="AFK07817">
        <property type="protein sequence ID" value="AFK07817"/>
        <property type="gene ID" value="Theba_2184"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2184"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="35744" checksum="C1F360194A1A683E" modified="2012-07-11" version="1" precursor="true">MKERILEIQDLTKHFRLRRTSLLRRPGSIKALNGISFSISRGESFGIVGESGCGKSTAGYSIVGLLKPTAGKVLFKGEEVNSMDANSLREFRKKVQLVFQDTSGSLNPRGTVEWILSEPLRAMGMAKKQIRNLVVDSLELVGLDKDLLGRFPHELSGGQKQRIGILNALILDPEVIIADEPVSSLDVSIQAQILNLMNELQDRLSLTYLFISHDLNVVHYFCNRIAVMYLGEIVELSESEELYRSPLHPYTQSLLSAIPGGSYRKTEKIILEGDAPSPMNPPSGCFFHPRCFKRMEICSRVKPRIIEVSKDHFVSCHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D2</accession>
    <name>I2F7D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">Theba_2202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2202"/>
    <dbReference type="EnsemblBacteria" id="AFK07835">
        <property type="protein sequence ID" value="AFK07835"/>
        <property type="gene ID" value="Theba_2202"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2202"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="184" mass="21349" checksum="8E3EB499A712EB49" modified="2012-07-11" version="1">MNSLLKDAENRMKKSVEKIVEEYAQMRTGRPSPALLESVKVDYYGVPTPINQIATITTTEDRSLVIKPWDRSVLSQVEKAIFASKLDLTPINDGVNIKLNFPVPTTEQREKWVKIARDNAEKGKIAIRNIRRDVIKEARELEKASEMTEDDLKKFEEEIQELTNRYIEEMDKAFEKKSKEIMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D5</accession>
    <name>I2F7D5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ORF">Theba_2205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731599.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2205"/>
    <dbReference type="EnsemblBacteria" id="AFK07838">
        <property type="protein sequence ID" value="AFK07838"/>
        <property type="gene ID" value="Theba_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2205"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_1_0"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="306" mass="33756" checksum="2D6776AEFC4F8DBF" modified="2012-07-11" version="1" precursor="true">MTFKADFVGKRKYFIALSLVLIVVSVIFIFTKGFNFGVDFTGGIEISVSVQDVDMTVAEMRELLSAEDPDFAAARIIKQRPLTEEGSSEQRSRFSIIVNTSESEESITAKMLAGLEVKDVTNDNILSVSTISGYAAQEIRGYAWIAVTVSMALLLLYITIRFKFSFGVGAILTLIHDVIIVLGFYSIFGIEFNAPVVASLLTLVGYSLNDTIVVYDRIRENTKKMRGKTIETVVNTSINDVIVRSINTSLTTFLAVLTLFIFSGEVLRPFAFGMLVGVVVGTYSSLYISSPVVIEWLKRSESRSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J2</accession>
    <name>I2F7J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731654.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2266"/>
    <dbReference type="EnsemblBacteria" id="AFK07895">
        <property type="protein sequence ID" value="AFK07895"/>
        <property type="gene ID" value="Theba_2266"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2266"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="347"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="6">
        <location>
            <begin position="429"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="5">
        <location>
            <begin position="570"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="829" mass="95328" checksum="9268523D31AA90D1" modified="2012-07-11" version="1">MSAKILVVDDSASDRFIIERMLREYDILTACDGIEAMQQIDEHGDIDIVILDLNMPKMDGFEVLKALKSNDRYKGLRTIILTNYDELDNEIEGLRLGAVDYIRKPVNMDSLKARIEIHVELLRIQQMLEQKLYEQGLTFDTIFQQAPIGIAISHGSEPSSGRESTVARFNPMFEKITGRTKDELMELGWVKITYPDDLDKDLINFKKLQRGELSSYSMEKRYVRPDGSIVWVQMTVAPLIISNDDRYNHICLAQEITRRKEMEADLLESERSKSVLLSHLPGLAYRCKYDRQWTMEFVSAGCSTLTGYSPESLINNKELAFCDLVAPEYRESLWIEWEKTLAKKVPLNYEYQTITAEGERKWVLEMGEGVFGEGGEVEALEGIIIDITYRKRIEDRLKYNSEHDRWTGLHNLNYLETLLERDGKHRRLENRAFVSINLNTVQSLTATYGFHYTQELMREVADMLGQYCTDRRMLFYTYENLFVFYLKDYKDREELTEFCRDIANMLESLLVAERIGGGIGVVQIDKDSDRDVDQLMKRLLIASEKALNIYDRDVGICFYDAEIEMEMIREEEIKRELAKIGADENYGELFLQYQPILDLESNRICGFEALSRLKIEKFGLVPALEFIPIAEKTKLIVPIGRRAIIRALRFLRRLKDNGFGGVLVSINVSAIQLLRSDFSENLFKMIDRTQVNPENIGLEITESVFASNYEEINRIIGGLKDSGIQIAIDDFGTGYSSLARERELNVNCLKIDKSFIDKLMCLDAKDTITSDIISMAHKLGHCVIAEGVEHEKQRQYLHSWGCDRIQGYLIGKPLDEEAAIGVLKASQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N1</accession>
    <name>I2F7N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CRISPR-associated helicase Cas3/CRISPR-associated endonuclease Cas3-HD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_2307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731689.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2307"/>
    <dbReference type="EnsemblBacteria" id="AFK07934">
        <property type="protein sequence ID" value="AFK07934"/>
        <property type="gene ID" value="Theba_2307"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2307"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010123_1_1_0"/>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="475"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="781" mass="89516" checksum="01BC8A53A4F40223" modified="2012-07-11" version="1">MSHVRSHPDRLLEKHTVGVWSLMTEEIENIGKFIDCENLFGISQSELSVLVKGIAIFHDLGKASEYFQSHLSGARVDSELSQHAAVGSLSVGHYLDGKIPDKSGAAILIAMAVIKYHHGSARDPKLILDSFDENQKFLEKIVRKLDENYLSWMEDLLDETVDLDLPSLIPRILSWERNYRKHREESGIKYYVLFQYLFSLLTWADRVDAAFRGDYKSERQTFSPDIVDIFRTTAGFDEPKTDMNLLRNNFYREAISNLDFTVGSMKGRTGIGKTLATLSLASKKREIIAEEQNYLPRIVYCLPFLSIIDQTFATIRDVLETSKIKVTSDILIQQHHLTELSYIKRKDGDENENYDAYLADILLNSWDSEIVITTFVSLFHSILTDRRNTRFFRLPGSVIILDEVQAIPPKYWKVISEVLEHLSKWGGTKIIFSSATIPQPFFVSSFPLIKGEYNLDRYDVRYLGKMGIEEFKYGLLEESVNTAMEEDKSLMIVLNTINCCKELFEHLQDSGSFTDENLHCLSSSLPPAVRREIIKNIKKKKGFQVLLTTQLIEAGVDISFDYCIRDLGPLDSVLQVAGRVNRSCEGNRGEMTVVDLLKEDSGRPFSWIYNDTIIWTTREILSSLKGSISEPALYELGDQYFSRLMNKGLENESLELLEALVKLDFERIAEFSLIEQLKGAVSFPVFLEIDDEAKRFWENYCEVLSTKPPIEAKFEYIAKRKQAVRNLAPYVVNVRLFLYPGAKKYTLPDIQHGFCYVSSDELEYYYDTKTGLKSDEESLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N7</accession>
    <name>I2F7N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731695.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2313"/>
    <dbReference type="EnsemblBacteria" id="AFK07940">
        <property type="protein sequence ID" value="AFK07940"/>
        <property type="gene ID" value="Theba_2313"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2313"/>
    <dbReference type="HOGENOM" id="CLU_2585597_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="80" mass="9287" checksum="88E453F4A9B5CA09" modified="2012-07-11" version="1" precursor="true">MSWIKELLSLITVFASYVESPGNGPEKKEKVKQMIKDALPDEQWKIDPEFFDFILDVLIDLVVMFLNKGLWKTAMKVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U0</accession>
    <name>I2F7U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-substrate-specific enzyme activase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731739.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2373"/>
    <dbReference type="EnsemblBacteria" id="AFK07993">
        <property type="protein sequence ID" value="AFK07993"/>
        <property type="gene ID" value="Theba_2373"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2373"/>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002393_2_0_0"/>
    <dbReference type="OrthoDB" id="8032at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="80"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="288"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="4">
        <location>
            <begin position="640"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1402" mass="156917" checksum="BC70824DBD00F705" modified="2012-07-11" version="1">MNRIGLCIGSSTISWYDGQTPRRLLHEGNPLKVLKSFLPEILETGLVVATGKKGRKLLNLPQIPEVEATEFAYKELKSKYGDHEAIMSVGGENFTLYKLNDKGNITAVFTGSKCASGTGEFFLQQMKRMDIDLDDANAVETDEIYELSSRCTVFCKSDCTHALNKGTPKESVLNGLGKVMSDKIGELMHRAGVKKILLVGGVTKNRLMLNHLKEIAEITIPDEALFFEAFGAYLYANTLEEIEIDEESVFKEGVMTFPKNEPLSKFVNMVDFKDMPFKTAESGDSCILGVDVGSTTTKAVVMRARDNAILASSYLRTMGDPIKATRQCLDEIRNSLDVPVEIIGLGVTGSGRKIVGLYCETSAVYNEIMAHARAASFFDREVDTIFEIGGQDAKYTFLSNGVALDYAMNEACSAGTGSFLEESAKESLNIDYREIGEYALKGQSPPNFSDQCAAFISSDIKTAINEGISREDICAGLVYSICLNYTNRVKAMRPVGKKVFMQGGVCLNHAVPVAMAAVTGKEIIVPPHPGLMGAFGVSLMVKEKLQAGQLEEERFELGALISKEVRYLNTFICNGGAEKCDRKCPIRIIEVGGKKFPFGGACNKYENVRLNLPINRNEYIYTTDREKIVFELPEEKGLETIGISKSLSMNTLFPLFSNFFSSLGFRIVVPEKSDPRGWDRKKSEFCFPVELSHGYIYDLLEKNPDYFFIPAVKGLEVANSVENSVFCPFVQSEPDWLMGSFEELKSKRILTDFFDFSRGFEKEKEKFVSLAKLLGRNRKEALTAFSNGVRSYEDSVRRIKEIGDRFLENLEKSDFGVVIFGRAYNAFSSDANMGIPEKLASRGIPVVTFDALPYENEKSYEKMYWAWGEMNLKAARYVRSNPKLFALYITNFSCGPDSFLISFFRDIMGKKPSLILELDSHTSDAGVETRIEAFADVVRSSLERKTNLGENNRAKRPKLLTNNGTFSIELQDGRHIPITDPSVKVIVPTMGEFAARLMAAAFEKVGINTHVLPRPTELEFQLGKSNSLSKECLPFHLTLGSLIRYLEENKDDESILMYFMPDTRGPCRFGQYSTYIDLWLDKNNASNVLLFSLNSENGYAGIGLKAKLRIWASMIIADEFCNVENALLTLASDRDEAVKATKDARKIILESVRRDSFSEMTKKLEEICESISHIPLKSDFESAPKVLLSGEIYVRNDEFSRKSLELFFADNGIIMHASPIEEWIYYLDYILLKKYVPTELGPLKRGTKHVEILVKQAFEKRIKKILEKSGLYKSHFVDIESMVNTSKDFLNPKLTGEAILTLGAVLFESIDTYDGVISIGPFGCMPTRIAEAVAERGLEHLRENSSKLKREIFKIAGNIPILFFESDGNPFTPTVESRLESFVVQVKRVKSLSMELESQEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F806</accession>
    <name>I2F806_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731794.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08059">
        <property type="protein sequence ID" value="AFK08059"/>
        <property type="gene ID" value="Theba_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2447"/>
    <dbReference type="eggNOG" id="ENOG5033S4E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508853_0_0_0"/>
    <dbReference type="OrthoDB" id="783673at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658732" evidence="1">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="538" mass="59749" checksum="C67F11324B76F6F9" modified="2012-07-11" version="1" precursor="true">MFRKALIAIVLVASVFAFSTQFKRTIEDKIVVQQDGSAIITRTEYVPASDLSKIYIQHRDALRERETANEAFANFYDEISKGYFFLYRSVPGFGDGDLRFKIEGNGDFTSTVSMKVTGLISESKDHPGSYQFSSKNFSEEKIMLKYLEDLIDGKAFETAFLGSSKNSLLTTKTTTIVLPEGSEIIDLLSPHGEKPSKDWSIDLGGGTKFKASLDLEKNTITLKEEIITGGGAPKNLMNEDNEELMAKLRDYAAYIAVFNNEKTGGKLSQPEPYFFKEDYSGSWNFGISHNFSTQFAYQTLSVEPGLNVSFTFGTSLLWEHQWKKVSWWKYKYVLKKFQTTVSLSPSLTPYIEVSSGAALSKTWEKNITTKTKWITFWVSCVPVTLVMEVKFDAKAEAGISGVIGFTASTTLSANTTLTVKYENGWSKNVNYSANYSGLQFDADAKVNAWAKGSLPLTLSAYVYYVAGPFVQFVPWLKGETNASAGSSTQVGYKVTAGFDVNGGVHMAGWLKDLCDGVPSVSYTFWNKSWTIANSTLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F846</accession>
    <name>I2F846_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731831.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2489"/>
    <dbReference type="EnsemblBacteria" id="AFK08099">
        <property type="protein sequence ID" value="AFK08099"/>
        <property type="gene ID" value="Theba_2489"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2489"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_3_1_0"/>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13489" checksum="105B5B3488058B20" modified="2012-07-11" version="1">MGKLIAIGTNDGFKLNEDHFGQSRYYDIYELDERKCAIKVEARPNPYYENHKHAEVDEILQVIGDCPVWIGAAMGKGSLKKLAEMNYEPVVLEPMTIDEALKAYLNEQKYDGKHKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F886</accession>
    <name>I2F886_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731864.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2535"/>
    <dbReference type="EnsemblBacteria" id="AFK08139">
        <property type="protein sequence ID" value="AFK08139"/>
        <property type="gene ID" value="Theba_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2535"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="514" mass="57954" checksum="B5D23DA181209222" modified="2012-07-11" version="1">MDEKVKENSKILFEIKGIDRNYPGVQALKDVTFKINKNDVIGFAGENGAGKSTLLKLIAGVEPPDKGEMFLEGKKYAPQSFREANILGVSMVFQEQNLVQSLTVYENLFLSHEKRFQVAGTLKKRQMISEAKRYLESFGLDIDPRKEVSQYSFHERQMLEIIRAFVIADMYKIETPLILLDEPTAALPEKEREILLDRIKSFSNKATFIFVSHRLSELMNACNRILILKDGQLVGEVDPEVSEEREIHPLMVGRELSADTYRVEDQKEFNGDEDPVLRVRNLSKKGLYDSVSLEVRRGEILGIGGLIGSGKKFLGETLFGVGEPTEGEIIIDGHSVSKATIRNMTKLRVGYVPSERKENGIIGLSTVAENLTITRLGEFSSRLGFINNRQESKLIKEGIEKFRIKATSEDLCFSLSGGNQQKIVLTKWIMKNLDILILDNPTRGIDIGAKEEIYTFIREAANKNLAIILITDDLLELIGLSNRIVIMKDGNISLIVDADKRRKPTEQELVRDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F887</accession>
    <name>I2F887_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase, DhaK subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731865.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2536"/>
    <dbReference type="EnsemblBacteria" id="AFK08140">
        <property type="protein sequence ID" value="AFK08140"/>
        <property type="gene ID" value="Theba_2536"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2536"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_0_0_0"/>
    <dbReference type="OrthoDB" id="857242at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="35591" checksum="1E07B56C4724187C" modified="2012-07-11" version="1">MKKLINDPKSVVIEMCQGMVKAFPENLALDEEFMVISRKNPNKNKVNLISGGGSGHEPAHAGFVGRGMLDAAVCGDVFASPSVMQVFNAIKHNHSEQGVLLVIKNYSGDVMNFESAAAMAEDYDIRVDSVCVNDDISIEKKEDRRGVAGTIFVHKIAGALAERGASLKQVKEIAQRVIDNVRTMGIALTSCTVPARGKPTFDLEEDKIEVGVGIHGEAGIFRDRLLSAKETAELIIERILGELSVSKDEEVAVLVNGFGGTPLQELFILNNEVATILNSKGIAVAKTLVGNYMTSIDMEGASISVLMLDEQMKRLLSAPCETAAWKETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F889</accession>
    <name>I2F889_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731867.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2538"/>
    <dbReference type="EnsemblBacteria" id="AFK08142">
        <property type="protein sequence ID" value="AFK08142"/>
        <property type="gene ID" value="Theba_2538"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2538"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745581_0_0_0"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="42929" checksum="AD6D5643D4CC0981" modified="2012-07-11" version="1" precursor="true">MLSSAFRLSCFILIVSLFIGSFCGAFWVDSYLDKINTSGVKRIEIRNYNTQDGELWIKFATLTAEYDESGNTIREGKLSGDGVLEFDYSYQYDSEGNMLTMQGKRIVNDSALEHSYEYKYDENGRQIEGIQYASDGSIISKYSAKYDESGNFVEGNDVQYDSSNSTRYLAGYNELGYMTEETKYIVYEYKEKEGLQTEFRNEYRYDDLGNLLLEIGYGKYGDFSYKYGYEYDEEGNLIKAYSYSASDTIVSVYEASYDDEGNLVRFILSDASGKILSEHEAQYDNGNMVLEVDCLSESRNLVYSAEYNSEGLKLKETNYNRNISGSPLTYSYEYLYDDRGNCIQEKYFVYLEDKDLWKPITKTVYLITYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D8</accession>
    <name>I2F8D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hexulose-6-phosphate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="gene ID" value="Theba_2591"/>
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    <dbReference type="eggNOG" id="COG0269">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="218" mass="23745" checksum="EC48DF71F4F3DBA1" modified="2012-07-11" version="1">MMIRLQLANDTHIKDSFLKTAKEVADYIDILEVGTPAVLAHGMTLVREISEILPDHEILADMKIVDGGYLEAAMAFESGADIVTVLGFASFKTISEVRKAADQFGGELMLDTIEISDLQSFAEKVSPLSPDYICIHTSADLSGVGESLHLLEYAKKIEIIRRVLPEAKIAVAGGISPDNLSHVFPLKPDVVIAGRSIWEAEDPARVAFQIKTRLEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E4</accession>
    <name>I2F8E4_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2597"/>
    <dbReference type="EnsemblBacteria" id="AFK08197">
        <property type="protein sequence ID" value="AFK08197"/>
        <property type="gene ID" value="Theba_2597"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG4608">
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="37146" checksum="BA68CC570A124BFA" modified="2012-07-11" version="1" precursor="true">MKILSTEGLKKFFPIKAGVFFQVVGHVRAMQSVTLEISRGETIGVVGESGCGKSTLGRTIVKIYEPTGGKILYHDENGEEHDITKGLGKNVRSKFRRDVQMIFQNPFDSLDPRMTVRDIIREPIEAHNLLSKKEAEDYVGELLMKVGLYPEYAQRYPHEFSGGQRQRIAIARSISVRPRLIICDEPTSALDVSVQSQIINLLQELREESEMSYIFISHNLDVVHHMSDRIMVMYLGNVVETAEARELFNNPAHPYTKALMASIPNWDPEDRKLQNIKLEGEPPSPINPPSGCPFHPRCPYKMDICSEEMPGNFEVAEGHKVACWLHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F1</accession>
    <name>I2F8F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2604"/>
    <dbReference type="EnsemblBacteria" id="AFK08204">
        <property type="protein sequence ID" value="AFK08204"/>
        <property type="gene ID" value="Theba_2604"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2604"/>
    <dbReference type="HOGENOM" id="CLU_3137546_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="49" mass="5463" checksum="35F7E1FC45068663" modified="2012-07-11" version="1">MASRSEVMLPPAGSEARWREEVIPGRASGEVMLALKHQEAKTKEKERAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G0</accession>
    <name>I2F8G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731921.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08213">
        <property type="protein sequence ID" value="AFK08213"/>
        <property type="gene ID" value="Theba_2613"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2613"/>
    <dbReference type="HOGENOM" id="CLU_2288176_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="101" mass="11638" checksum="3ACD21DE19D73B18" modified="2012-07-11" version="1">MERVIVTIEASMEGTVDNFLLMRHRDVEYLKEALVTDDFERMMEIVKNLNNEGRCCGFDFIASIGTKLFAAASEKNKLAAEICVDLFSWYMTRIRTEVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K6</accession>
    <name>I2F8K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487267.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2660"/>
    <dbReference type="EnsemblBacteria" id="AFK08259">
        <property type="protein sequence ID" value="AFK08259"/>
        <property type="gene ID" value="Theba_2660"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2660"/>
    <dbReference type="eggNOG" id="ENOG502Z9ES">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056932_0_0_0"/>
    <dbReference type="OrthoDB" id="1495233at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027602">
        <property type="entry name" value="PGA_system"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04332">
        <property type="entry name" value="gamma_Glu_sys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="367" mass="39750" checksum="1145DC1E0F2FBFA6" modified="2012-07-11" version="1" precursor="true">MKSSHVLLTVPYSRANISLKWLLLGAMIGVLGFFLVGQSRQRIESPYYADQFAAARLMASSIEELSRFRESLGIEIDPSVDPNLTGLIGPEFTEITTTLGNLQAKRTSTNPDFAALMVKFFKQLNLEKGDPVAIGASGSFPSLLLATLCACETLELQPFVIYSIGASEHGATHPEFTFVHMLNRLVEVGLLRDSLVAVSLGGNYDTASGMFFPGARELMTDIALSSGKTFIYEESLQESIDKRLEIYIQEAEGLPSVFVNVGGAAPNFGNSLIATSLDNGLLTAFSSIPEGDERGLIFEFAELGVPVIHLLNIRDLALDNGIPIDPVPFPEPGESGVFFVDSFSLPLIIVFLSLMVLCIVVGRVIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N0</accession>
    <name>I2F8N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">buk</name>
        <name evidence="10" type="ORF">Theba_2684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731978.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2684"/>
    <dbReference type="EnsemblBacteria" id="AFK08283">
        <property type="protein sequence ID" value="AFK08283"/>
        <property type="gene ID" value="Theba_2684"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2684"/>
    <dbReference type="eggNOG" id="COG3426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048716_0_0_0"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="346" mass="38357" checksum="ADCF201CC4D85092" modified="2012-07-11" version="1">MSLILVINPGSTSTKVAVFRDTEEVFKKTIPLDDDMLDLPLFPDQYTIRKRQIVKELDLNGVRPSDLAAVAARGGRLKPLESGVYRVNKEMVDDARRGLQGMHPANTAVVIASEMAEEFGIQAFTVDPISVDELAEWARYTGINEIRRNSLSHALNMKAVARKAATKLGKNYEDAKLIVAHLGGGSSVSAHSNGRMVDLYNSDKEGPFSVERAGALPSHELAEFARERDDYLDYLTHRGGLFSHYGMRDVESIARRVMKEEIDSAPLEAYIYNIAKYSYSLLAVFDGFPDALALTGGVVKCDYVRERLLSKLKGFRVLLFPGEYEMESLAEGAHRVISGSEDALDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R3</accession>
    <name>I2F8R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732009.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2718"/>
    <dbReference type="EnsemblBacteria" id="AFK08316">
        <property type="protein sequence ID" value="AFK08316"/>
        <property type="gene ID" value="Theba_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2718"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608892_0_0_0"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="165" mass="17946" checksum="963AF5293AF85046" modified="2012-07-11" version="1">MEFAAVYYSRSGSTRAIAESFAGSCGAKLFKLEDLKPRKSVSGFSALLGLGSALKEPLPDVRSFDLIVLFTPIFAWHPSPQMNTFVRNGDLKGKHVYLVGVGAGESNVKALERFRKEVEKAGAKVLGSKNLKGLQIKQDIKEVEPKLLESGSQLAGTIERAFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I2</accession>
    <name>I2F1I2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="9" type="ORF">Theba_0031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729963.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0031"/>
    <dbReference type="EnsemblBacteria" id="AFK05785">
        <property type="protein sequence ID" value="AFK05785"/>
        <property type="gene ID" value="Theba_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0031"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_0"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="62"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="344"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="246"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="441" mass="47800" checksum="8CBCDAAB50449AA7" modified="2012-07-11" version="1">MKKKRSYVCDVCGYESPAWFGRCPSCHEWNTAISFVSEGDKDENISFADIEVRPLSQVDTTESSRIDTKIEELNRSLGGGVVPGSAVLISGEPGIGKSTLMLQLSALIAGERPVLYISAEESARQLRLRAERLKIQRKEQIEVVSATEIDFLGSLAIEKYGMIVVDSLQTIKMSSVPSLPGSVVQVRECANMLVSLAKSSDIPVLIVSHITKGGQIAGPKLVEHVVDTVLYFESSKTGFRFLRTIKNRFGPSDEIAVFEMTSEGLKEVPDISSLFVEDYISAPGNVVSAIYEGSRAMLIEVQALVSKPVYGTPRRLASGIPLERLLLVTAVLTKRAGIPLDSLDLYMNVAGGLQIEDTGVDLAIAAALISSYTDTSIPEGVAFFGEIGLDGTVRSVSSMEKRIERAKKSSFMRIVAPEGRNGIKDVKQLLKFIGGMKSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I4</accession>
    <name>I2F1I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487469.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0033"/>
    <dbReference type="EnsemblBacteria" id="AFK05787">
        <property type="protein sequence ID" value="AFK05787"/>
        <property type="gene ID" value="Theba_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0033"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640614_0_0_0"/>
    <dbReference type="OrthoDB" id="1339264at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="428" mass="48307" checksum="2ADFC1BDFECE010A" modified="2012-07-11" version="1">MIVTNVLAFTNDLKNPLVDDALVRFEDGEITFVGPRREYSIQEDEEIVDGEKGILLPSFFNAHYSIYSSISPYPVRVLKGERTEIDFFGGLLNSGRKEVNSELVRLSAELAVMKAIRSGSVAMSGPVVDHPDVDPELYREIAAKYGVYLAVGPVLTEDTLDEIGGRWENVTRDASFCPMLYVSNLATFEEEAIQKLRGLYEKGMNLNLLIFDMKRENEVCLFRWGESLVERLMKNGILIPECGVVYGGNLSETDMDIISSRRIFVTKSLRSEMYAGTFQPNISDLLGRGMQVCLGTGFLGADILGEAKEIILTERCHRGFDNSIIDYEIRKTLFDNNYKLFQRFFGKHSGVLKEGYSADLVLAKSSLDLEKFDMNLPITLQLVLKSSFDTSFEKVWNSGELIFDKGVPQRISKKELREISKQLRSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J7</accession>
    <name>I2F1J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0048"/>
    <dbReference type="EnsemblBacteria" id="AFK05800">
        <property type="protein sequence ID" value="AFK05800"/>
        <property type="gene ID" value="Theba_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0048"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_0_0"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="116"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="225"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="447" mass="48711" checksum="E72CD1801C039FFF" modified="2012-07-11" version="1">MDFNTFADKAFKISKEKGFDEAEIYYSKGGEFQLSSLNGEIDSYTDASSIEVYFRGLKNGKIGTAFSEILSEEAATLLVEEAFENCSIASGEDVYIFHDGTGEYRDFEGYSGAFQKKTVKEKIDTVVSLEKLALEYDKRIVMVPTCRTADTWSEVTIINTLGLNRRYKSDGGFAVVVSLAGDEKSKKTGFSFSLVRTPEELDVKGVAEEASKRAIDQLGARNVKSGKYRVVFRNDVFGQLFGTFTSMYSADNVQRGLSVLKGKMGTVIGSSKLTVYDDPFLSESPYSKPFDDEGVPTRKKALVEKGELKTFLYDLRTAAKDGTKSTGNSVRGTYRSKPSIAPVNTVVRSGDLSFDALLESMGEGILVTDLTGLHSGTNQVSGEFSLGASGFFVKDGKISNPIEQFTISSNILKVYSGILEVGSDSVSSIYRVSSPSVLIDEIDVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K2</accession>
    <name>I2F1K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05805">
        <property type="protein sequence ID" value="AFK05805"/>
        <property type="gene ID" value="Theba_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0054"/>
    <dbReference type="HOGENOM" id="CLU_1702190_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="154" mass="16973" checksum="03B9746F1EF65486" modified="2012-07-11" version="1" precursor="true">MKKRDRGAISVAYARRKEKAYKYFTAAGVIVGLLSIVLIVTANQMSTNIVQDADSIRPIFIAGIVFAPISFFIYVFALVTSLSAGIRNWNLVLGFLSSFQAVVSLIFARDILLLDSSLKLSLQTPNWSSCILWSILVASLLLTFFVGVFSRKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R5</accession>
    <name>I2F1R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730033.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0120"/>
    <dbReference type="EnsemblBacteria" id="AFK05868">
        <property type="protein sequence ID" value="AFK05868"/>
        <property type="gene ID" value="Theba_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0120"/>
    <dbReference type="HOGENOM" id="CLU_1675810_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="18144" checksum="8082F1476C6F6A2E" modified="2012-07-11" version="1" precursor="true">MRKGIKGLFGVLIVVSIILSGCIVTPPVDLGQWVLKDYWQHYILSEHYYTYSYLLYPGYNCDNVKIVVSCSKAPSYGFEVWIMTQTQFNNFVNSNVVSVVDHFTVYTGNYTFYSSAMSPGGTYRVVIDNTDYGWVETNWDGYDDYCRFDADIYFHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R9</accession>
    <name>I2F1R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730037.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05872">
        <property type="protein sequence ID" value="AFK05872"/>
        <property type="gene ID" value="Theba_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0125"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030249_0_0_0"/>
    <dbReference type="OrthoDB" id="1194941at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657561" evidence="1">
        <location>
            <begin position="25"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="494" mass="56405" checksum="44AA3395832F9BEE" modified="2012-07-11" version="1" precursor="true">MRKISILLILSLAVVLFSSDNCFTQESVEHFKKLLESQGFTVQEGSLYLFNPADLFGNYILPSCFCNNADSPYAVYLIPEGPGQMTPNKYPWTYKLKENEAIIYLGWTPPPMVYFSYQTFLAGRFYKDAFHRIFGNLGDTINISTINTGESIEEDTEGTDFNAPTIIINTPDRNTDAVLRAEIARAGFDVGIVNTEVLPSALLRLGLEHDDDELTFLFRTAFFENEADREFYTSDPPLVGYKEILVKPPYQSNFRGWVFRVTPPEDLKSDPFPIPPLRVRATGDTSELELAKTMDRLREAILKEYEGLQFSELKSYRWFEESYHGIQTTTDVFGETRDTVYFRTDTFELSESGEDFAIVYGPIHSLTGKSIYSSFILYTGDIVKDLLPLQSRIMLGFLSVNSQMSEESKLGLKGSAKRFLPDDPNADLFYVWKIAKANPDNEDYYAVVPESNYERITYNELFVAFRAYIDPKLAVSAAYEEILMDKVIYFSQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U8</accession>
    <name>I2F1U8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Theba_0160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730066.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0160"/>
    <dbReference type="EnsemblBacteria" id="AFK05901">
        <property type="protein sequence ID" value="AFK05901"/>
        <property type="gene ID" value="Theba_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0160"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_0"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="13">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK05901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="37511" checksum="3785199E3526DD19" modified="2012-07-11" version="1">MKGVIESYEKFLPITPKTPKITLLEGNTPLIYLENISKQYGVKVYVKYEGANPTGSFKDRGMVLAIAKAIEEGSRAVICASTGNTSASAAAYSARTGLKSIILIPEGKIAIGKLAQAMIYGAKVIQIDGNFDNCLELAKKISENYPVTLVNSLNPYRLEGQKTAAFEIIDVLGRAPDYHFIPVGNAGNISAYWMGYREYREKGLSESQPRMMGFQAEGAAPIVYDRVFEHPETIATAIRIGNPASWKKAVAARDESGGVIEALTDEEILHAQKLLASAEGVFCEPASAASFGGFLRKAREGLFEASDIAVCTLTGNGLKDPDAVLKSVDRPLVVENDLEVVLKEAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F202</accession>
    <name>I2F202_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BIG2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730117.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0221"/>
    <dbReference type="EnsemblBacteria" id="AFK05955">
        <property type="protein sequence ID" value="AFK05955"/>
        <property type="gene ID" value="Theba_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0221"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672346_0_0_0"/>
    <dbReference type="OrthoDB" id="112089at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="409" mass="43190" checksum="6F85132896CE3A20" modified="2012-07-11" version="1" precursor="true">MKRISSFALAILLVLMLFATQGCFLFRNVTISLESESLTIGVGESIQIEFKVKPEDATVKFSSSDESVASVSSTGVVIGISAGKAEITIEGTKDKYKTAVKKVSVQVVGEDYYSVTFTVSDSGGVIQGAEVSFNSDAKTTDSEGKAVFTDVLPGSKDYSISKDGYEDATGTVKVDSDESVDVTLIKKSYTITASAGTGGSIDPSGEVIVEHGSSKTFTMSPSEGYSVEDVLVDGESVGPRDTYTFSNVTSNHTISVSFTTLPPETYTVTFNVTDSEGTLQGAEVSFNGESKNTDVQGKAVFVNVLSGSKAYTISKEGYNNETGTVNVDSDKSVNVTLTKKTYTITASAGTGGSIDPSGEVIVEHGSSKTFTISPSEGYSVEDVIVDGESVGPRDTYTFNKHNFKSYNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F213</accession>
    <name>I2F213_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730128.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0232"/>
    <dbReference type="EnsemblBacteria" id="AFK05966">
        <property type="protein sequence ID" value="AFK05966"/>
        <property type="gene ID" value="Theba_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0232"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454006_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="423"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="601" mass="64900" checksum="B955D4731CBB405E" modified="2012-07-11" version="1" precursor="true">MLDRKSLKSVCLVFFVLILIAFSSCSGSKPPEIVIPDQSVRQYQLLQVDLSSFVSDSESDLLFSLQEGPGRIVGSVYELVPESDLSGRARVSLLIRDNKGNDFSSAFFVNIFEGQLPDNSKARLDFVVPQQYAEVGDVIRLGLPGFRLASDDLEFEIIEANASLNAFVEDGVLTLKPSDDAVGEDALLIRASDGEDSVEFKVPYFVRRRNLSPTLSIGDQSVVEGDSVRVDLSQFARDPDGEIVKYEVLGGPGTVSDEGIYILTAPYGSSGTHTVTVEVEDDRGGLGRGSFRVHVMPADSSERRTLIVGGEEALYTSIQAAIDQSRDGDVVLVMPGEYCENLILDKAIELRGSSRDSVLLRGQNQNAPVIMVRTGNGFMISGMTVESNLTTIQVSRITGTIVDCHVVGGRFAVSYSSIDSSTLIVKNCSFSSLPDAEGEINSRLTGLYAYGSGSVRIEGCDFIRSGTGIYITNDVKYEIVESVFRENRIAVSVAGNTNGHISNNKFTGNVENGLLISSVGVTEVSNNMFYKNVIHGLDLYLSMCTDCGCGGKVFKGTVTGGGNIFDSTEGICPQSHTWPENFYVVDELLGRSATEMNQGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F219</accession>
    <name>I2F219_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">Theba_0238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730134.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0238"/>
    <dbReference type="EnsemblBacteria" id="AFK05972">
        <property type="protein sequence ID" value="AFK05972"/>
        <property type="gene ID" value="Theba_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0238"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_0"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="60" mass="6786" checksum="E7DD75FF122201EF" modified="2012-07-11" version="1">MAVPKQKRSRSRTHLKRAKMYSSIKVAVSTCPNCGEPKQPHRVCLHCGYYGGRQILEIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F263</accession>
    <name>I2F263_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">Theba_0284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491752.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0284"/>
    <dbReference type="EnsemblBacteria" id="AFK06016">
        <property type="protein sequence ID" value="AFK06016"/>
        <property type="gene ID" value="Theba_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0284"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_0"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="96" mass="11045" checksum="187723D45EC61F74" modified="2012-07-11" version="1">MVKIRLTRMGRRNRPFFRLVVVDSQKRRDGAYIDSLGFYDPIRDPGIMSVDVDKAVSWIMKGAQPTETARSILARFGVMKKVHELKYVKESGEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F289</accession>
    <name>I2F289_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenocysteine lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730185.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0312"/>
    <dbReference type="EnsemblBacteria" id="AFK06042">
        <property type="protein sequence ID" value="AFK06042"/>
        <property type="gene ID" value="Theba_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0312"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_0_0"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="29"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="408" mass="45362" checksum="D25ED4628D9E2995" modified="2012-07-11" version="1">MSLKETSDISIKEVRRDFPVFRHYPSLAYLDSAATAQKPQSVIDAVKGFYERENANVHRAVYPLAEKSTALYESSRSEVARFIGAERDELIFTKGSTESLNIIANALATSGRYKTFVVPTFEHHSNFLPWQYHSLKNEIKFVALPIMGAELTMTEVEENLTGVEAPFVFSIGGLINATGYRTPFEDLTELVHSFGGLIVIDGAQLVPHEIFDFKKVNSDFLVFSGHKMLAETGIGCLVGRAELLDDLTPFVFGGGMVDRVSIETSSYAKERTSRLEGGTQNISGAVSLASACRYLNKIGMSAIHKHVSYLTETAREMLKQISNVTVYSPPDSHAILLFSHKNIHSHDLAEFLGRTQEVAIRSGHHCAQLQMEALGITSACRASFYFYNTVEDVERLIEGISKAERWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D4</accession>
    <name>I2F2D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="13" type="ORF">Theba_0358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730219.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0358"/>
    <dbReference type="EnsemblBacteria" id="AFK06087">
        <property type="protein sequence ID" value="AFK06087"/>
        <property type="gene ID" value="Theba_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0358"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_0"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="2"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="335"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="482" mass="55216" checksum="4D0833531D5B781A" modified="2012-07-11" version="1">MIRVRFAPSPTGYLHVGGARTALFNYLFARHYGGKLVLRVEDTDISRSTKEYEDQLMESLLWLGITWDEGPDVGGAFGPYRQSERGPIYREMIGDLLQRGQAYEVHAYPEEIEELHDKLLSEGKAPHYDQEMLEAFNTDERISEFESKGLRPVVFFKMPRKEYRLPDLIKGEVVFKEGAIGDFVIMRSNGQPIYNFAVVADDITMEISHVIRGDDHLSNTLRQLALYEAFGAPIPSFAHVSMILGPDGKKLSKRHGDTSVEQFRERGFLPEAFFNFLTLLGWSHPDGKEILNHEEIVESFSIERVNTSAAIFDEAKAKWMNGVYIRESDLERITDLAVPFIIQSKLMTAEDAVANRKWLKRAVDSVRKGVETLSEIPDKMRLYFEDPQVTFFTPSNDVEKGVYKALEAFKERVEYLDSWNNDEIIGTIRGILKDLKPDRKAFYMTLRKILTSVEEGPELVDIIFLLGRNKTLNRLQRAINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E5</accession>
    <name>I2F2E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_0369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0369"/>
    <dbReference type="EnsemblBacteria" id="AFK06098">
        <property type="protein sequence ID" value="AFK06098"/>
        <property type="gene ID" value="Theba_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0369"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_3_0"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="179" mass="19726" checksum="68D624C8180421E5" modified="2012-07-11" version="1" precursor="true">MNLPNILTLSRMLLTIPALLMLMSGSVVGHYFSFIVFVVAALTDFFDGRIARKRGLVTDLGKFLDQISDKILVTSVFLGFMGLSRISLWFLFILIFRDTLVSGIRMVASSKGKVIAADIFGKAKTVAQITLLILLYSNLLWGFPAPSVMVWFEILVAIITALSGGNYLLKNLDIFKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F1</accession>
    <name>I2F2F1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsH</name>
        <name evidence="9" type="ORF">Theba_0376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0376"/>
    <dbReference type="MEROPS" id="M41.021"/>
    <dbReference type="EnsemblBacteria" id="AFK06104">
        <property type="protein sequence ID" value="AFK06104"/>
        <property type="gene ID" value="Theba_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0376"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="202"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="633" mass="69654" checksum="FA8722B29891BBBA" modified="2012-07-11" version="1" precursor="true">MDQKPRIGMIVFYVVLGLFLLIALRGLYPTETSIVVPYTKFLDDFNNIIDIVVYDSGKVVYITGDNPRRSLETYVPSQTLVTQTFQNHIDLLAERGANITFERGSDSLFWVNLLGTLIPLGIIIFIWFFLMRSMSGRNSQAFTFTKSPAKKYVNTDKRVTFKDVAGVDEAQQELADIVSYLKDPSIFADTGARMPKGLLLVGPPGTGKTLLARAVAGEAGVPFFFISGSDFVELFVGVGAARVRDLFTQAKSSAPSILFIDEIDAVGRHRGAGLGGGHDEREQTLNQILVEMDGFDAKTGVIVIAATNRPDILDKALLRPGRFDKKISVDPPDLKGRSEILKIHMRGKPIDPEVDVQLLARRTPGFVGADLENLINEAAILSARKKKKMIGMAELEEAIDRVLAGPAKRSRIINDREKKILAYHELGHAVVGLILPKAFPVHKVTIIPRGTSTLGFTESLPLEDRYLITKSELLDNMAQALGGRAAEDLVFGEITTGAASDLERASAMARSMVTQFGMSERLGPIAWGKEEEEVFLGRELTRMKNYSEEIASEIDSEVKTIVLTCYEKAKRVLSDHRKKLDDAAEYLLQKETISGKELADILGLEGGNYYKDDLETIDIAPGASAEEPDIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I3</accession>
    <name>I2F2I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family 4 glycosyl hydrolase, alpha-galactosidase/6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730252.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0408"/>
    <dbReference type="EnsemblBacteria" id="AFK06136">
        <property type="protein sequence ID" value="AFK06136"/>
        <property type="gene ID" value="Theba_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0408"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="198"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="472" mass="53376" checksum="44FE8B88DD334F5B" modified="2012-07-11" version="1">MSSVNISIIGAGSAVFSLRLVSDLCKTEGLYGSKVTLMDINQDRLDAVYILASRFAEEMNANLEFSKTTVLEEAIKGRDFVVNSALIGGHDFLDRVRAIGEKHGYFRGIDSQEFNMVSDYYTLTNWNQLSFFLKIAKLMERHAPDAWLLQAANPVFEGTTLIRRYSSIKMVGFCHGHYDVREVAETLGIPIEEVDWQVAGVNHGIWLNRFKRNGEDLYALIQKYAANYDPRRFKPINPFNVQMSPATIDMYRFYGLVPIGDTVRNSGWKHHYNQETLVKWYGAPWGSPDSEPGWQWYKEQLGQVTGATVALAKAIEQFPEASLEKLIVEGSRGLSGDFARQAAQLYNKNSLSGEQHIPFIDAIINDSSARFVLNTLNEGAIPGIEDNVAVEVPALVDREGIHTEAIDPPLPERIVKWYLKPRVLRMEWALEAFIERDSDLIVEILLKDPRTKSYEQAKAVVREIFETEGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M1</accession>
    <name>I2F2M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730289.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0447"/>
    <dbReference type="EnsemblBacteria" id="AFK06174">
        <property type="protein sequence ID" value="AFK06174"/>
        <property type="gene ID" value="Theba_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0447"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="66"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="498" mass="55835" checksum="D00290B280F348A7" modified="2012-07-11" version="1" precursor="true">MKKLLLAVLVTFLSVAVFGVSDSVLVMAIETEPVGFDPTLVTAFASHRVLENVYDGLLKYDENMNLVPNLAEDFEVVDPYTIVFKIREGVKFHNGETLTVEDVLFTFERIRDPEVKAPAASYYGEVETIRSLDGNKVEFKLKIPMASSLLPNFAGVNSAILSKSFVESGANLQLETNGTGPFYIAEFVAGNYIRLRKNADYFVAGLPYLDEIKMMIMPEEVTRVSALRNGDVDIAKISEPLSLNQLASDKFVIYRTPVLSYYLLGFNTTRGPLSKPEVRNALSYAVSREMIVKAVAFDEATVTGPLNPELDFWALQPNQFEEYSYNPSKAKQLLAEAGYPNGFEFEIVAAQRYNFDKVAQVIQAQLAEIGVIAKINLVEWGIFISKWRESDFDSFISMNSGSIDPDIQFNRTFRTGGSTNVFLYSNPEVDDLLDRGRSESDMNARKLIYEEVQRKLVEESPILFLYSPNTLFASNNSVKGFRSLANESLVFLRETSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M7</accession>
    <name>I2F2M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein with conserved CXXC pairs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730294.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0453"/>
    <dbReference type="EnsemblBacteria" id="AFK06180">
        <property type="protein sequence ID" value="AFK06180"/>
        <property type="gene ID" value="Theba_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0453"/>
    <dbReference type="eggNOG" id="COG3862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148086_0_0_0"/>
    <dbReference type="OrthoDB" id="1751763at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="124" mass="13748" checksum="36E1983EB3787012" modified="2012-07-11" version="1">MERHITCVICPVSCKISVRKSGSEYEIRGNRCPRGKEYALNELIMPKRILTTSVKVINGEIPLVSVKTSGAIDRSIIKEKMDLVRKISVEAPVQIGDVLMDDIDGQGTALIATRPVKRIQTFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S9</accession>
    <name>I2F2S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730339.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0506"/>
    <dbReference type="EnsemblBacteria" id="AFK06232">
        <property type="protein sequence ID" value="AFK06232"/>
        <property type="gene ID" value="Theba_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0506"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_0"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="304" mass="34478" checksum="77195AD0709C3800" modified="2012-07-11" version="1" precursor="true">MKIVRTLFLVLLIVIAVAVVNGIFSVTMARIFLNRIEREGRYLKVGEEELFLKVLGEGKPMLMIHGFPGSHLDFSELAKLLSSNRKVYLVDLPGSGLSEASSKGDYSRKGYAELLVDLMNLLNIEKADIIGHSLGGEIALNIGYYYSERVENLILIDSYAFTEQKLVPDFISSSKVLTWIAMRFYYQTYPVQRYLYTKRLGDKSYFVHEEFGKYFALVDRMSIQFLSEFIKDSDGGSLSGMLGEIDLNVLIIWGERDEILPLDYAKKISEEIPGSTLKIIEGRGHAPFIDKPERVAEEILSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X4</accession>
    <name>I2F2X4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730374.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0554"/>
    <dbReference type="EnsemblBacteria" id="AFK06277">
        <property type="protein sequence ID" value="AFK06277"/>
        <property type="gene ID" value="Theba_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0554"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_0"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="5"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="311" mass="34070" checksum="D19BF6EBE051ECC0" modified="2012-07-11" version="1">MVAWIFPGQGSQYVGMGKSFCDESPLFREFLELSGQLLGFDMLTMMLEGQEDELKLTHNAQPAILSLSIAISDALIERWGKPDICAGLSLGEFSALVVAGTLRYADALRLVRLRGTAMQQMMSSEDGTMAAIIGLPEKVVEEICLEISSSEEVIVANYNCPGQVVISGLSEKVRSAMNKAMEKGAKKCVELSVSAPFHSRYLRPVGEVLREFLNGIDVKPPEIPVISNVTGGLFPKDPNAIRELLIEQAYSPVKWEQSIRKMIELGADRFVEVGPGKVLSGFMKKIDRSVSVESTENEGLGILKELQEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X6</accession>
    <name>I2F2X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxymyristoyl/3-hydroxydecanoyl-(Acyl carrier protein) dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730376.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0556"/>
    <dbReference type="EnsemblBacteria" id="AFK06279">
        <property type="protein sequence ID" value="AFK06279"/>
        <property type="gene ID" value="Theba_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0556"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_2_0"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="135" mass="15112" checksum="37EE9DE8A51522C9" modified="2012-07-11" version="1">MRDKEFVKERIPHREPFLLVDGVISMTDSEILAFRDLLENDPVFEGHFPGYPIYPGVLILEGLAQTAGILLLKPNETPLFAGIERARFKTIVRPPCRIEYSVKLIDSRMNVAKLETSAYAEGKLAAKAILLVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z4</accession>
    <name>I2F2Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NusG_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492212.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0578"/>
    <dbReference type="EnsemblBacteria" id="AFK06297">
        <property type="protein sequence ID" value="AFK06297"/>
        <property type="gene ID" value="Theba_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0578"/>
    <dbReference type="eggNOG" id="COG5341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130936_1_2_0"/>
    <dbReference type="OrthoDB" id="1864717at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NusG_II" evidence="1">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="12575" checksum="A2DF9FB3259DD0B5" modified="2012-07-11" version="1" precursor="true">MKFTTRNDVLIVIVAFALVILFAFPRGNGSSFAEVYCNGRLVRTIDLSSDSEIFLDVGMVVKVQGGKISVIDSDCPEKLCVAQGAVNMPNIPIVCVPNRTLIKIVSDRSEVDAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F380</accession>
    <name>I2F380_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ORF">Theba_0666</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730457.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0666"/>
    <dbReference type="EnsemblBacteria" id="AFK06383">
        <property type="protein sequence ID" value="AFK06383"/>
        <property type="gene ID" value="Theba_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0666"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_0"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="86"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="402"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFK06383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="817" mass="92859" checksum="9AA074CE5D257655" modified="2012-07-11" version="1">MGLLSKIFDKNNMLLKKYSRVVESINSLEKTVSRYEKVDFQKKTEEFKARVSEGETLDSFLPEAFALAREAAKRTVGMRPFDVQLMGALALDEGKIAEMKTGEGKTLVATMPLYLNALSGRGCHLATVNDYLAKRDAGWMGPVYEYLGLKAGFIQATMEPSQRKEAYGCDITYGTANEFGFDYLRDNLVYSLENKVQRGHNYVIVDEADSILIDEARTPLIISGPAQDSSNLYRQFAFFAKRFVAEKDFVVDEKDRTVTLTEEGIAKAEKLLQIDNLYDPSNYDYIFHLLNALKAMNLYKREVDYLVTQEGEVVIVDEFTGRLLPGRRYSEGLHQAIEAKENVQIRQESVTFATITFQNYFKLYSKVSGMTGTAATEESEFISMYNTPVAIIPTNKKVIREDKEDSIYKTREEKNEAIINEIAERYEKGQPVLVGTTSIEKSEFLSKLLQKKGVPHEVLNAKYHEREAEIVAKAGERKTVTIATNMAGRGTDIKLGEGVVDLGGLYVLGTERHESRRIDNQLVGRSGRQGDPGESKFFLSTEDDLLRLFGGERMQSIMNTLKIEKGQPIEHPLLSRIISSAQKKIEGMHFEIRKRLYELDSVIDQQRSAIYAHRNWVLKGEEIDSNVLEIIEDVVERRLSGLDRLPSFDEIKVSFGFLPAGDIESLKNLKSVEDLRSKTLSVLHDIYEEKKSAFGDEFPQVIKYIMLRMIDERWRRHLEAIEHLKDSVGLRAYGQKDPVLEFKKESFILFQQLTDSLYDDIASAIVRIVRVDSDKAKQNADKEFKSLQAVHSDFSGGDKKKEVAGKKKGTKRFKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F389</accession>
    <name>I2F389_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ORF">Theba_0675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492341.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0675"/>
    <dbReference type="EnsemblBacteria" id="AFK06392">
        <property type="protein sequence ID" value="AFK06392"/>
        <property type="gene ID" value="Theba_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0675"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_0"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="398" mass="43748" checksum="C6C922E9C509DF62" modified="2012-07-11" version="1">MAKEKFERSKPHLNIGTIGHIDHGKTTLTAAITKSLAFKGLADFSPFDSIDKAPEEKARGITINVSHIEYQTEKRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAATDGVMPQTREHVLLARQVNVPAMVVYINKVDAVDDEELVELVEEEVRELLSSYEFPGDELPVIKGSALKALEAESPNEWTESIYELLKACDDYFPEPVRETDKPFLMPIEDIFTITGRGTVVTGRIERGAVHVGDEVEIIGLSYETKKTVCTGVEMFRKLLDEGQAGDNIGALLRGVAKEEVKRGQVLAKPGSITPHKKFTANVYVLKKEEGGRHSPFTKGYRPQFFIKTADVTGEIADLPEGVEMVIPGDNVEMTIQLIYPVAIEKGMRFAIREGGRTVGAGVVSSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F396</accession>
    <name>I2F396_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="13" type="ORF">Theba_0682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730465.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0682"/>
    <dbReference type="EnsemblBacteria" id="AFK06399">
        <property type="protein sequence ID" value="AFK06399"/>
        <property type="gene ID" value="Theba_0682"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0682"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_1_0"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="144" mass="16398" checksum="05BC98399F3D6575" modified="2012-07-11" version="1">MAQTVQRDKRSVFHRKRKEEKAATPVSQAKAVAKFVRISPRKARSVVNAIRNKEVGEAFQILEFSPKKASRLVYKVLRSAVANAENNFGLNVDSLYVEKAVVDDGPRMKRLWPRGRGRADIQQKRFSHITVVVANREEISNPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D0</accession>
    <name>I2F3D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0716"/>
    <dbReference type="EnsemblBacteria" id="AFK06433">
        <property type="protein sequence ID" value="AFK06433"/>
        <property type="gene ID" value="Theba_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0716"/>
    <dbReference type="HOGENOM" id="CLU_1426492_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="190" mass="22261" checksum="E9088CC72D6DC62E" modified="2012-07-11" version="1" precursor="true">MVDVNLYSRKRRVSRLKYSLIVLLIIILLIFGSRFFVTQAFEIRLRQVSRMKGYLFDNTGTYLTGNLKEDIDMMYEKKQEYIAIRNKLSRQVNDLRKHVDLKSVEMDVFRTIEAYLEDENAMKTIASRIQFESGVGNSFYYLIFEGKEMFFPTPHTTPTLLARPSVRGNLDFAELYSLQLVDLEVGDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D9</accession>
    <name>I2F3D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">DNA ligase</fullName>
            <ecNumber evidence="10 11">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="13" type="ORF">Theba_0725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730500.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0725"/>
    <dbReference type="EnsemblBacteria" id="AFK06442">
        <property type="protein sequence ID" value="AFK06442"/>
        <property type="gene ID" value="Theba_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0725"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_0"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="587"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="35"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="665" mass="74990" checksum="E1CD3603FD264716" modified="2012-07-11" version="1">MITFEEARKRIDELRKEIDYHAYRYYVLDDPEIPDSEYDNLLRTLIDLEEQYPELKTPDSPSIRVGLKPVASFKEVVHEYRLFSLDNTYSEEEVLQFDRRVREELQIEIVRYMCELKIDGLSISVKYDNGLLVRGATRGNGFVGEDVTENIRAIKSIPLRLRQDLSVEVRGEVYLPKDVFYEINRARSKGELQVFANPRNAAAGTLRQLDPREVAKRRLNAFFYHVVEPSKLQLKSQNEQLQFLKSIGMRVEPNSELAEGTDGVIAFWKKWSESKSSLNYAVDGTVVKVDDLYAQEELGYTTKAPRWAIAFKFPAEQAMTKLIKVTFGVGRTGTITPVAELEPVQLAGTTVKRASMHNFDFISEKDIRLFDIVIVQKAGEIIPQIVRSIPEKRTGKEKRITPPSRCPVCGGEVGREKEEDVALKCLNPTCPAKLSRRIQFFCSRDAMDIEGLGEKLVERIVEAGLVKNPSDLYKLNKDDLLSLGEGIGEKTASNLIEAIQKSRSNPLFKLITGLGIPGVGSKTSKDLANYFGSLRGLVSADEKELRNVSGIGEQLAKDIKRYFSSPEVKKEVEELLKYVNIKDEDSPGSKPLKGMKFVVTGTLPGYSRKEIQEKIIKLGGEVASSVSKNTDFLLLGENPGSKEQKARDLGIKIIDERDFEEMIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F4</accession>
    <name>I2F3F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of uncharacterized ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730511.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0742"/>
    <dbReference type="EnsemblBacteria" id="AFK06457">
        <property type="protein sequence ID" value="AFK06457"/>
        <property type="gene ID" value="Theba_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0742"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="258"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="502" mass="55880" checksum="E2831C6936AE1644" modified="2012-07-11" version="1" precursor="true">MSKPVLEINDLNKTYEISETKALDGVALTLFSGEITTLLGENAAGKTTLVKVIMGIEKPDSGSMVFKGEKYLPSGPHFANEKGLGMVPQSIKVVDKLSVIENLILGFRRNRKKVRMKDYRESLRELMKQYSLQLPLDNEVASLSTGQRQKLEILRVLQNSPDVIIFDEPTTLISNREKEELFEIITRLRSQGKAVVFITHKLREAYSISDKIVVLRSGKVVFSESRYKTSIKELQELLYGGEFCALRVQSPTSDESLLRVQEVSVEGSSNTEAVKGVSFEARRGEILFVSGVAGNGQEELLDGIFGMRRVLSGRVILDGKDITGLRPFKLRKLGLAALHYDRDNIASCKGSSIRDNLLVYSISNGKWVVEEKKHVFSARKLLRDYGVTFGKIQDPISSLSGGNLQKLLLAREISSDPKVLLLGEPFRGLDVKSLESVKFLLMEAKKRIAIVAFSADVDEALTIADRILIMSEGRVVFSSDIRPGLSTPDLRKYLFGAMEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F7</accession>
    <name>I2F3F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730514.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0745"/>
    <dbReference type="EnsemblBacteria" id="AFK06460">
        <property type="protein sequence ID" value="AFK06460"/>
        <property type="gene ID" value="Theba_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0745"/>
    <dbReference type="eggNOG" id="COG2317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_0"/>
    <dbReference type="OrthoDB" id="239313at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="500" mass="57381" checksum="E6B052898B9E47AD" modified="2012-07-11" version="1">MKLIDELRSKYSEITYLHSAAALMAWDMRTYIPPKGAEMRSEVLGYVSTLAFRKAVSEEMGTLLSQLAEGKIEEELTEDEKAMVRVATKAYKRVKAIPPDLYHRFSVLSSKSEKVWERSRNENDFKSIAPYLEEIIDLLREMARLYGYEENPYDALLEGYEEGMTAKKLRKIIEPLKSELIPFTNRILKEGRSPNTEILRGRFSRKAQEKLSRKALKLIGYDFKAGRLDETVHPFTIGIGVNDVRVTTKYSPDEFTPSLFGSIHEGGHAIYEQGLPVSLRDTPLYGACSLGIHESQSRMMENMVGRSMEFLSFFYPQIQKAYPSNFRDVPLGDFYRAINNVKPSLIRIEADEVTYNLHIMVRFELEEALIKGDLKVSDLPEAWNSKMKEYLGIVPQTNTDGVLQDVHWPSGTIGYFPSYMLGNLYAAQMFAKAKEDIPGLEKRIEKGDVLSLVDWLRDNIHSVGRRYEPEKLLKIATGKELDPSYFLNYVMEKYSKIYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G8</accession>
    <name>I2F3G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730525.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0756"/>
    <dbReference type="EnsemblBacteria" id="AFK06471">
        <property type="protein sequence ID" value="AFK06471"/>
        <property type="gene ID" value="Theba_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0756"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695992_0_0_0"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658504" evidence="1">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="396" mass="44128" checksum="7DEE1C819C4477B5" modified="2012-07-11" version="1" precursor="true">MKRVILATVLLLFSLTAFGADRIVGIEVTGVHKTNPRVVINISGLQIGEELDIEKVYRAKRNLEDCGLFTDVYLQLNDADGDYKLIISVQERNTIYPYFGEYLALGVGDKSFLGSGVNLYGGIRFLRFTDEKLLGVLPKPQFFWGGLTLGASTFSAFGSGLDPFLELTLFREVPWRDDLILTLDSFSAGTTYSFEDLVVGISYTYEKATFDTTPLNNYSLSILSGAFAFGDEENYEEKRGNFYGQTALSYGFGKGINYLNQKASFTYWYRIIGRIYVQSDTMAGLTYFGQAPVTKQFYLGGNLDLKGWEPYSFNPRFFLLEILEAGIPLTESFGISPSDEMSVFIPKLYLMGALGDNETLGMSIGIGFEWKTPLGVAVEPQLFFGGSGLKFYLELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K1</accession>
    <name>I2F3K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730557.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0790"/>
    <dbReference type="EnsemblBacteria" id="AFK06504">
        <property type="protein sequence ID" value="AFK06504"/>
        <property type="gene ID" value="Theba_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0790"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569614_0_0_0"/>
    <dbReference type="OrthoDB" id="1403084at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="479" mass="54352" checksum="9AED60C37D00AE97" modified="2012-07-11" version="1" precursor="true">MSREILKKPRFNAAIFTLFYLALFFMVFSVSLQTAMIFFATFTVVIILEPWARFAERSFRIKRSISLGIGLAVIFSGLTLLIVFLTTPVAKEASKFYNIVRDFFPSAEETEITSFEVNANIDTFLSEEEFLSKLSPEEVESLDLLSKDLKRYYSDIMDPITADSEDLNEDLALLEETLKNRSDYVVIISSSKQKNASYEEIHKIISNYLNPEAAELLSASVLDNAMVVHSQELWRNVVDYFMPKNIDPSTQRATYESVRNFLIQVQSSLMKFLPGILEKIPSFLTSTGLVLFFTIVGAIYLSYYFLTVKDFIPRFYPKKVRGIAISFLEDTYKNLERYVISVVVIALIVGVVVGIVVHSMGLKYSLLMGTWAAFTNLIPIVGVPLEFIPLFLLAVSTQDLVLVITLMIILVIVHASAFILFLVFMKGYNRINPVIIILMIVIAGQLWGLFGAIIAVPFAIVLKMTWMHFFSPMLEEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K5</accession>
    <name>I2F3K5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">Theba_0794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730560.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0794"/>
    <dbReference type="EnsemblBacteria" id="AFK06508">
        <property type="protein sequence ID" value="AFK06508"/>
        <property type="gene ID" value="Theba_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0794"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_0"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TsaD"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T6A_TsaD_YgjD"/>
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    </dbReference>
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        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
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    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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        <location>
            <position position="114"/>
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        <ligand>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK06508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="35797" checksum="68E6367D826F37D4" modified="2012-07-11" version="1">MKVLALESSCDETAVAIIEDGRLLSSQISSQIDIHKRFGGVVPEIAARKHLEIIDRMVSRSLEEADLDIKEIDVFASTMGPGLVGSLLIGLSFAKGMAIAMNKPFVGVNHLFGHVYANFLRYPLLKPPFMVLLVSGGHTEILVLKDWDRIELVGKTRDDAAGEAFDKIARLLGLGYPGGPAIQEAAEKGQAKYHFPRPLREKGNFDFSFSGLKTSVLYFMKKNPLASVSDVAASAQEAIVDSLVTKAFDAAESLHLDEIAFAGGVASNSLLREWARVQSEVSGIKAYFPPVDLCTDNAAMIALVAHEKAKRGLFSPLSTNAVPYLTLDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R2</accession>
    <name>I2F3R2_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
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        <name evidence="3" type="ORF">Theba_0854</name>
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        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="16352" checksum="3D8A0A8FE0EE1AB6" modified="2012-07-11" version="1">MKNAIILLVEDKMMDIELTLDSFRQVGLTNHVEIAKTGERALDYVFGNGPFSDREAFPLPDLVLLDLKLPGISGHEVLQEMKKSELTKRIPVVVLTSSREEGDRAICYDSGVNSFLVKPVNFKEFLVVARAIGDYWLTINVGPPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R5</accession>
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        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="263" mass="29440" checksum="BC952BC7242F3669" modified="2012-07-11" version="1" precursor="true">MFVRRWFSSRKRASVVICHGIGEHSGRYDGFATYLNGKGFDVFAADFPGHGMHSGTRGFIKSFDDFTSLVKEVADRVKKIQPELPLFLFGHSMGGLIATRVIEVHPDLFNAAALSAPHLFSAKESVKNLLPLISIIRRVAPKTTFSSSSRFTPADLSNNERAVQRYIADPYVHDRVSPNLFFGLEDSIEQALKEADRIMTPTLIVYGSADRVVDPVGGKELYEKINVEKKMLEIPGGKHELFADEERRSQFFGAISSFFLEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T2</accession>
    <name>I2F3T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730623.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0875"/>
    <dbReference type="EnsemblBacteria" id="AFK06585">
        <property type="protein sequence ID" value="AFK06585"/>
        <property type="gene ID" value="Theba_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0875"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658287" evidence="1">
        <location>
            <begin position="21"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="80"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="572" mass="65195" checksum="8B4125A56856FAFC" modified="2012-07-11" version="1" precursor="true">MKRALILVSMLTMLFVAGLASEPDYFIADCNGKPGGSLSIDGTDPLSLNPAFGMDGGSAITLDLITESLLNENEFGFPEHPALCKDWWISEDGFTLSFVIREGLQWSDGQPFTIEDVRWTFEEIYLVAEMTLFGNSNFMSSAGDLPLVEVEGNTISFTWSEPNALAPRTIGLTPILPKHCLEKNVTEGTFSTAWNIGEFEKVVVMGPFVVGKYYQGDMIVLERNPYYWKFDSSGFRLPYLDKIFITVSTNMEQVLIRFEAGELDIINPTADQFPRILSMAEEKGWKAVTGQPRPLSEFLMFNFNVPDPVKSEWFRNEHFRKAIAYAMDRKSVLDTVYCGLGVILHGPVSSSSIYYDPQVEEFSYDFSPTRARLELKRGGFDWRSDGTCIDEYGNPVSFQILTCSWNSQWIGIVTILSDQLSNIGINATTAFMDWDSFVTRAYLGTFDSMTMGEGSAEPGLLETVYHSKGTSHYWNFHPDYNPSDHITEDTYFYPDWQKRIDEILEAQKSVIELEERCRLFSEFQLIMAEHMPLIFMTTQLLLYAYDSDIHHGPWIYGAMLGMPWRPWDVWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T9</accession>
    <name>I2F3T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730630.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0882"/>
    <dbReference type="EnsemblBacteria" id="AFK06592">
        <property type="protein sequence ID" value="AFK06592"/>
        <property type="gene ID" value="Theba_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0882"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_2_1_0"/>
    <dbReference type="OrthoDB" id="1886662at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="115" mass="12628" checksum="4E78B3DBF4DE8141" modified="2012-07-11" version="1">MQVTTEFGKIDISLQAISSIVKKVVSESYGPVNVGSPQTGFLTKLFGTGEDSRKGIKVTEEIDGTLEIDIDLILEYGVRIPTVVENIQENVFHKLKELTEATNIKVNIHVVGLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U0</accession>
    <name>I2F3U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="8">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="8">DXP synthase</shortName>
            <shortName evidence="8">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dxs</name>
        <name evidence="10" type="ORF">Theba_0883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730631.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0883"/>
    <dbReference type="EnsemblBacteria" id="AFK06593">
        <property type="protein sequence ID" value="AFK06593"/>
        <property type="gene ID" value="Theba_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0883"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_0"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="9">
        <location>
            <begin position="310"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="8">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="626" mass="68507" checksum="BB336AB1F045A0C4" modified="2012-07-11" version="1">MNEQPLFRRLKDYSYTQLEVLAGEIRDTITRVVSSNTGHLASNLGTVELTIALYRVFDPDEDIIIWDTGHQAYTHKLLTGRFGSFGSLRKKGGISGFLNRKESPYDFFGAGHVGTALPAAMGIEQAENIFRNAKNIVVVAGDGALTSGLALEALNQMKDIGSKIKVVVNDNGMSIGKNVGSLSSSLAELRLNPVYREMKGDLKNALETMRLGSLEQFLSKIKSGLKASILGGNIFEDMGLNYVGPVKGHDFQELEAVFSAVKQLPEPFFVHIVTKKGKGLEYAESNPTRFHSVSRIDPENGEKISRNGELTYSEVFGNVLTELAKKDPSISAITAAMPDGTGLAGFAAKHTARFFDLGITEQLCTTFASGMAAAGTKPVFAVYSTFLQRALDQLIHDVALQDLPVLFAIDRAGIVGQDGATHNGIFDISFLSMIPNMQILAPSSLKELANMIFTLFTEKWMDHPTAIRYPRETELQNIDDIVSNLRKMDPFKWEKVIDGKETAILATGSMVSRSREAALLNGCALFNCRSIKPLDKAALGKIFADYDLIVTVEEGIMSGGFGSNVALEASRQNYNGRIDIIAIEDRFSSHGTREEVLNELGLDARGIENRISKLRGEKNASNYRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X8</accession>
    <name>I2F3X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730654.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0925"/>
    <dbReference type="EnsemblBacteria" id="AFK06631">
        <property type="protein sequence ID" value="AFK06631"/>
        <property type="gene ID" value="Theba_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0925"/>
    <dbReference type="eggNOG" id="ENOG5033775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639050_0_0_0"/>
    <dbReference type="OrthoDB" id="1099240at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="49597" checksum="9C1AE2CAEDDACC74" modified="2012-07-11" version="1" precursor="true">MEEKYSIGRGVLLLIIFALLSYIFTSMTVWTTDGKYLFVSRYLRINQHNRVISGENFAPDQYRFGSYYLVENLFKFLPIEWLDENSEELSRMLLSSDYWTEDKKGMIDSYFPVAEREKLVSDSEKVIEELVDSVTGKNILLNNALKAFASSLNWQVYLTDPATTALLIGERLPEDIKRAVELSSDENRILNGHITARFFFNILTLILLYGFCRVFSSPSESLLSTVAFQAIMPLTTMYFGWETFHAAALFIGGLLLIAKRGRFYLLCLLMALGSLFRPDHMIFLSLIYLLFNLERGLSWQKRAFILSKSLIAGAIPAVLTFVVSRFIFPDAEYSVDLIQFRYNMTYIWSWIYPMIFASIPLLFLREVKRCGFFRKTWFWVIPFIAMNFLIARTAEVRLFTPVIAFLAPLIGIGLQRFFPGRSMENTAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y4</accession>
    <name>I2F3Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492646.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0931"/>
    <dbReference type="EnsemblBacteria" id="AFK06637">
        <property type="protein sequence ID" value="AFK06637"/>
        <property type="gene ID" value="Theba_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0931"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_0"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="16885" checksum="DF2A804838D36A51" modified="2012-07-11" version="1">MKIALTVNGKLHDIDIDPGEYLLDVLRRIGYKSVRRSCNSASCGTCTVLLNGKPILSCSTFAASVDGQNIETVEGMADGEKLHPIQEAILEEGGAQCGYCIPGLIMAGEALLRENSDPSDEEIKLALNGNICRCTGYEPQNRAIKKAAKVMRGELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F457</accession>
    <name>I2F457_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-substrate-specific enzyme activase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730721.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1005"/>
    <dbReference type="EnsemblBacteria" id="AFK06710">
        <property type="protein sequence ID" value="AFK06710"/>
        <property type="gene ID" value="Theba_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1005"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035213_0_0_0"/>
    <dbReference type="OrthoDB" id="1837697at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="317"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="572" mass="62081" checksum="7E78BEA1B2721282" modified="2012-07-11" version="1">MIYYTCSYLPLEVLMGSDIAFQRLMTSSPTSSHELGCNLCGYAKTVYQKGMELDSNDCLLIVDSCDAMRRVGDLLDELSLANVFILRLPWKRDGESVRFLAVEIQRLVYFLESSGISVDLREGILRFNKLVDFVQANEKRLAAGDLSNLYLQPLNGMQATYTSKYGATLGKSRLAITGGITDIGALDAAVKKTGGVIVMNDTCLGARPFSERTQEKPDPFQAVAERLLKWRSPCARFSEGEFRSNGEVDATVFVAPKFCDFYDFVRPKDGKSVYRIELDYPINSQGQLSTRIGALMEKNSVRSVSPSKEGIKMLFAGVDSGSTTTNAVLIDKEGRIIFSKTLKTGVRASNTAEALIAEMTEVASKEGKRIGKCVSTGYGRLLVSSASDRITEISCHARGVFELFPEARGIIDVGGQDSKVIRLSPDGNVDDFAMNDKCAAGTGRFLEVTAAALELEIDEMALMARKRNKDISISSVCTVFAESEVVSLIGMGERIENISSGLFRAIAKRVGAMYSRLGSPVPLVFTGGVARNSGVVDALKELFGTEIIVPEAPEIVGAFGAALIARDSVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F482</accession>
    <name>I2F482_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase, C-terminal domain of histone macro H2A1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730744.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1030"/>
    <dbReference type="EnsemblBacteria" id="AFK06735">
        <property type="protein sequence ID" value="AFK06735"/>
        <property type="gene ID" value="Theba_1030"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1030"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_7_0_0"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="186" mass="20205" checksum="012AE8A6CF3FBBEA" modified="2012-07-11" version="1">MKSFILREGRVIQLEISDITEQEVDVIVNAANSYLRHGGGVAGALVRAGGKEIQLESDAYVRKNGPLKTSEVAVTGAGNLLAKKIIHVFGPQYGELDLESKLYCSFANVLKKAAEMTAVTLATPAISTGIFGVPVSICAEQFLKSVMDHFSQNKSSSLRLIKMCLLDRKAYDEFLSIALDFFSSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F490</accession>
    <name>I2F490_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnS</name>
        <name evidence="7" type="ORF">Theba_1038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492779.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1038"/>
    <dbReference type="EnsemblBacteria" id="AFK06743">
        <property type="protein sequence ID" value="AFK06743"/>
        <property type="gene ID" value="Theba_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1038"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_0"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="132"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="432" mass="49594" checksum="8A1A4C0616C4B3C2" modified="2012-07-11" version="1">MKVAEISSLGKHINEHVQIRGWLRRKRSSGKIQFLFLRDGSGFVQAIVEKSSVPESVFQVAASLKMESSLIVTGLVKAEERAPGGVEVLVEDVEILQIPEKDFPINKPDHSIDFLMDNRHLWLRTQRQTHVLKIRHEIIRAVREFYNDRGFVLVDTPIFTGSIGESAGNTFEIDYFDYGKAYLAQTGQLYLEAAAMALGKVYNLGPTFRAEKSKTRRHLIEFWMNEAEVAYYGHDDNIKLQEDLVTYVVKKTLERAGEYLRSVGRDTSRLEKIETPFPRITYDEAIKLLVKKGFDIKWGDDIGGDEETAIANEFEKPVVVERYPRMMKAFYMQPDPERPEVVLCDDMLAPEGYGEIIGASERIHDRDLLVERIQEYGLDVESYDWYLDLRDYGTVPHSGFGMGIERIVAWIAGLEHIREAIPFARTLYRIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B3</accession>
    <name>I2F4B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730766.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1061"/>
    <dbReference type="EnsemblBacteria" id="AFK06766">
        <property type="protein sequence ID" value="AFK06766"/>
        <property type="gene ID" value="Theba_1061"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1061"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_4_1_0"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="227" mass="25632" checksum="892264C5471EECC0" modified="2012-07-11" version="1">MNPLIFNLGRCTLFGGIRVGELERIFENVKHRISFFLPGELIEEQNSVCDEMLVLLQGQTKAQMQDFSGKVITIETMEAPSILASGFLFATENHLPVDIVSTAKSAILYIERDGILWLCKEYEVFLRNLLRDMGDRLTTLAEKVWMLSLNTLNQRLANFLLRQSDDLGDEFELKTTKEELAGALGVARPSLSRVFSEFVAQGLIKQDGRQIRILDRAALKRISGHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K7</accession>
    <name>I2F4K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1162"/>
    <dbReference type="EnsemblBacteria" id="AFK06860">
        <property type="protein sequence ID" value="AFK06860"/>
        <property type="gene ID" value="Theba_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1162"/>
    <dbReference type="eggNOG" id="ENOG5032UNN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370145_0_0_0"/>
    <dbReference type="OrthoDB" id="1942435at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="195" mass="21525" checksum="7A751B3A241A444F" modified="2012-07-11" version="1">MNMSFSDIEVALKALNSQLKRIGKKVGLVVCGGTALNALGLVQRTTADIDVVGFAEEVEDQIVVSKAEFPDWLLDSAGKVARDMGLPKDWINNGPTSLVELGLPEGFSERLIKVQIGSSLSVYYISRIDQIYFKLYASADRGGYHVDDLMKLEPTEKEIVEAAKWTMTHDVSPAFRGIMIDLLRRLGFDDASKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L7</accession>
    <name>I2F4L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730859.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06870">
        <property type="protein sequence ID" value="AFK06870"/>
        <property type="gene ID" value="Theba_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1172"/>
    <dbReference type="eggNOG" id="ENOG502ZC3Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043399_3_1_0"/>
    <dbReference type="OrthoDB" id="1825163at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="PTHR11927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="288" mass="33500" checksum="5D40F33E76F65EE0" modified="2012-07-11" version="1">MRVVWFGGGLGNQMFQYGLYCFLKKNNQEVKADCTQYSTTPMNNGFELERLFNLDIAHANLDVISKLTGGNRLSPRKVIWKLFRKPKVYFEEKIPFSFDPDVLKGNNRYLKGYWQNMNYLEPCAKELRDVFTFPAFSSDNNKRLADEIAKVEAVGVHFRRGDFLKSSNLGLFGGICSDQYYLRAIQTMENTVVEPVFYVFCDDPQWAKNSFSDARFTVIDWNIGSNSYRDMQLMSLCKHNIIANSTFSWWAAWLNRNPNRTVIAPERMVNRDLDFSGIFPNDWIRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q5</accession>
    <name>I2F4Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06908">
        <property type="protein sequence ID" value="AFK06908"/>
        <property type="gene ID" value="Theba_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1212"/>
    <dbReference type="HOGENOM" id="CLU_2538644_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="83" mass="9177" checksum="16E2776020D07CF0" modified="2012-07-11" version="1" precursor="true">MTDNVVFTALSGFSFLSVKRFFGARSRARPQTGALNKSISGQAHWGRVQGRLIKAGSTNDIVRAQGCFFWESKASNFLKPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S4</accession>
    <name>I2F4S4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigA</name>
        <name evidence="9" type="ORF">Theba_1239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486573.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1239"/>
    <dbReference type="EnsemblBacteria" id="AFK06927">
        <property type="protein sequence ID" value="AFK06927"/>
        <property type="gene ID" value="Theba_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1239"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_3_0"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="343"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="47540" checksum="CCABBB0EA2F1B1CC" modified="2012-07-11" version="1">MEKQKKTKSGAKVIADNIKSLAEKIADDEADSDETGDNSALMTKEEIDKRIKKLLRQGKKKGFVTYEDIDSAFPPDYEGFDSSLVESIYEEFEKNKINIVEKEPVEDDDDIESESSEELVSILETTPEMYDNISLKDPIKMYLKEIGKISLLTPSRERELARRAQKGEPKAKEELITANLRLVVSIAKRYIGRGLTFLDLIQEGNIGLIKAVEKFDWKKGYKFSTYATWWIRQAITRAIADQARTIRVPVHMVETINKLNKVIREHLQDHGEYPTIEELGNLTGKTPEKIEEILAASKETVSLESPISGDEESTMGDFIHDDSMEQPEEAAMKMLLREQIDQILDTLSPREAMVLKMRYGLLDGKTKTLEEVGQFFNVTRERIRQIEVKALRKLRHPSRSKQLKALLGMLNTSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T6</accession>
    <name>I2F4T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730920.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1251"/>
    <dbReference type="EnsemblBacteria" id="AFK06939">
        <property type="protein sequence ID" value="AFK06939"/>
        <property type="gene ID" value="Theba_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1251"/>
    <dbReference type="eggNOG" id="COG3804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050509_1_1_0"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="139"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="341" mass="37274" checksum="DBEDAF79DEEBC6E0" modified="2012-07-11" version="1" precursor="true">MAYRVLVWGLGAMGSGVARNVSQKEGLRLVGAVEKDPQKIGRDLGEYLGGEKTGRQIYSDVEKAVSETRPDIVVIATNSFVEEVLTKIETVARHHVDILTIAEEMAFPFFSHPEESEVLENIAWRYGVSILGTGINPGFVLDLLIIAMTGTCLKVDRIEARRINDLSPFGRTVMKTQGVGTSPEEFKKGIETGEIVGHIGFQQSIAMIGNALGWDIDRIEESREPIISKTERRTSVAHVLPGMVAGCRHIGRGYCGDKLMIELIHPQQILPEKEGVDTGDYIDIFGEPDIHLSIKPEIPGGKGTIALATNMIPAVIESGPGLLEMSELPIPRCLLNEIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V9</accession>
    <name>I2F4V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="10" type="ORF">Theba_1274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730940.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1274"/>
    <dbReference type="EnsemblBacteria" id="AFK06962">
        <property type="protein sequence ID" value="AFK06962"/>
        <property type="gene ID" value="Theba_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1274"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_0"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="8">
        <location>
            <begin position="213"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G" evidence="9">
        <location>
            <begin position="213"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="223"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="242"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="439" mass="48707" checksum="21C49E0398500AEC" modified="2012-07-11" version="1">MFNDPICALSTPRGLSATAVIRCSGKGIVSKISHLLPDLKTLKPRHAHLTSFMEGDRYIDEVVVVFFQGPASYTGEDLVELSFHGNPLIIENALESLFRVGFRMALPGEFTKRAVLNGKFDLVKAEAINALIASKTEKSLEAAIKSFRGSLSEEVASFREKMVRLLASVEVELNYPDEIETDYSSLYDELVSLKKEMCEFIEKSRNGVVISQGIKTAIVGETNVGKSTLLNALLKRDRAIVSEIPGTTRDTIEEDLNIGGVLFRVIDTAGIRQAENEIEVLGIERSLKAIEEAELVILLRDPHNPESKDLEEELRNKGKRLIVAANKSDIRKVEQHHFDVVISARTGEGLKDLEKLMLKRTEEITSIGDEVIISARQKQKLLDAVDYIARSIEAIEGNITVDVLSTMIEQAARSLDELLGTHITEDVLERIFSDFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X4</accession>
    <name>I2F4X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1289"/>
    <dbReference type="EnsemblBacteria" id="AFK06977">
        <property type="protein sequence ID" value="AFK06977"/>
        <property type="gene ID" value="Theba_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1289"/>
    <dbReference type="HOGENOM" id="CLU_137433_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="127" mass="14232" checksum="6378F072D35DB535" modified="2012-07-11" version="1" precursor="true">MRRNVIRVALVVVLVALGFGLYVLGKQHTIFVENKDIVVDGVEYKSANTINVIVDDVDLEDVKKGKRKVAYSAGPWHKIKAVEVLPDGTTREIERKFTLSPNDTAVINLVALFEVEEGWLTIEQAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X7</accession>
    <name>I2F4X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730956.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1292"/>
    <dbReference type="EnsemblBacteria" id="AFK06980">
        <property type="protein sequence ID" value="AFK06980"/>
        <property type="gene ID" value="Theba_1292"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1292"/>
    <dbReference type="eggNOG" id="ENOG5033BDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173972_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="109" mass="12514" checksum="ED8362E3FE61C455" modified="2012-07-11" version="1">MDEKTLESILKLKEDQINAMDFKKLLGYIRSIDEYFRGNSQIDVEIALKAYQKAIQLLTAARLRLITLKKEKEELDQQYSSFLNSIEAQDVSEEPPETSAEGEDGKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y3</accession>
    <name>I2F4Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486672.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1298"/>
    <dbReference type="EnsemblBacteria" id="AFK06986">
        <property type="protein sequence ID" value="AFK06986"/>
        <property type="gene ID" value="Theba_1298"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1298"/>
    <dbReference type="eggNOG" id="ENOG5032WTK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828249_0_0_0"/>
    <dbReference type="OrthoDB" id="2156954at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="345" mass="37709" checksum="7CC9D0B3EE8E7E2E" modified="2012-07-11" version="1" precursor="true">MNKKYPSITKLILAGVLGLLALLIPFTAGKILLAIAGIVVVALSLKKFKWLLITLGILFLVIPIVALGVINGIGSNCLNWPLGFIDDPSILQWFNWIENDGYEYYGNNEGGYNRKGSDHKTYMPDQYVDGAKEIVFSGLGFEISFDENSDKIHIPSKLEINRYGERLQISMPNDMKNSTAQITIGTLSELDRLEFRTVFLRLNDKVNVAKMEIQTISGEIRGEIMASKMISIEGTSLSITGSLKAPEIIIENVPSLSFMGSVEAEKFTVQNGVALAFSMDASKIENLSIHGTVVNGRIKFSDSWTGSRRVNVSGIGGSLNLLMPTGSGGFELITSGRVSVVTEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F500</accession>
    <name>I2F500_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, linocin/CFP29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730974.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1315"/>
    <dbReference type="MEROPS" id="U56.001"/>
    <dbReference type="EnsemblBacteria" id="AFK07003">
        <property type="protein sequence ID" value="AFK07003"/>
        <property type="gene ID" value="Theba_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1315"/>
    <dbReference type="eggNOG" id="COG1659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089875_1_0_0"/>
    <dbReference type="OrthoDB" id="1252793at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="263" mass="29389" checksum="32F22C68D0906403" modified="2012-07-11" version="1">MDLFKRQLAPLTSEAWEEINERAKQVLKSYLSARKVVSVVGPKGWEYSFVPEGRVKILEKEGEVGVGLRKAKPLLEVRVPFKLVRWEMDDIERGAKDSDLGPLEEAAKQIALFEENVIYNGYEKATVKGIVESVENKPIPLGSKPNEIIESLSKAAQVLKDNFVDGPFALIVNPETMAILNSHVSGYPLVKRIESFLGTDIVVSRVVKDALLLPKDHEDLELVIGGDFEIGYQSHTDKEVELFISESFTFRVLDPAIIVKLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F504</accession>
    <name>I2F504_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730977.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1319"/>
    <dbReference type="EnsemblBacteria" id="AFK07007">
        <property type="protein sequence ID" value="AFK07007"/>
        <property type="gene ID" value="Theba_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1319"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_0_0"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="291" mass="31741" checksum="6C658BD79BDCE64E" modified="2012-07-11" version="1">MRDFVLERPRSISEVLDTLQRHGNKAMVKSGGTDVIVWLHKSIKEPDYIVDLTAVEQLKGIVVNEDNVEVKALVTLNEVIGDDSLNRYFPALVQACKAHSDPLIRNRATVVGNVCAAVPSGDMIAPLVCYDAKVEITGPNGSRKVPVSEFITGPKRTSLGTDEIVTGIRIALPAVETSGCYLKAIRREALDIAQAAVCCTLFKGDNREFRIAFCAVSARPLRATEAEKLLNSCSNIDDEVIDQAAELAADAVDPITDVRASREYRVEMIAELTRRAISRCLERPAGEGVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F512</accession>
    <name>I2F512_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyridoxal-phosphate dependent TrpB-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1327</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730982.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1327"/>
    <dbReference type="EnsemblBacteria" id="AFK07015">
        <property type="protein sequence ID" value="AFK07015"/>
        <property type="gene ID" value="Theba_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1327"/>
    <dbReference type="eggNOG" id="COG1350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042858_1_0_0"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="9">
        <location>
            <begin position="78"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="447" mass="49394" checksum="F4233D94920A7910" modified="2012-07-11" version="1">MKKRTVVNLKSEELPRSWYNIKADLPFKMDPPLNPATNEVINPEDMMAIFPKSIVEQEMSEERFIPIPEPVLDEYAVFRPSPLIRATFLEEYLNTPARIYYKYEGNSPTGSHKTNTAIAQAYYNKTDGITELTTETGAGQWGSALSYAGRKFGLTVRVFMVRNSFQSKPMRQHMMRMFDGTVEPSPGENTESGRNFLKDRKNFSGSLGMAISEAIEIVLNSKTKKYSLGSVLDHVLLHQTVIGLEVEKQLEMLGEKPSSIIGCHGGGSNFGGTILPFVKRTFNGDDIEFIACEPESCPSLSKGEYRYDSGDSAGFTPLLKMYTLGREFVPPAIHAGGLRYHGAAPLISRLVKEGIVTPIAFPQEETFRAGLLFATTEGIIPAPESCHAIAGAVRKAIEARETGEEKVIVFTLSGNGALDLSSFTSTLEAHRDVLNFDKLRESSIVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F526</accession>
    <name>I2F526_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486756.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1341"/>
    <dbReference type="EnsemblBacteria" id="AFK07029">
        <property type="protein sequence ID" value="AFK07029"/>
        <property type="gene ID" value="Theba_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1341"/>
    <dbReference type="HOGENOM" id="CLU_2093956_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="13042" checksum="98D11B89EB5C8F29" modified="2012-07-11" version="1" precursor="true">MLKAVKPFPPKRKGVASFTLLIAILIVCTAMVTVLAPVDTIMVSRRLSSWYFRLALTIKSIYLAEPEETEINGLQMEKSSRTVYSNCAKIEIINYHIIEGEKSFDFEIVGNITDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F553</accession>
    <name>I2F553_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731002.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1368"/>
    <dbReference type="EnsemblBacteria" id="AFK07056">
        <property type="protein sequence ID" value="AFK07056"/>
        <property type="gene ID" value="Theba_1368"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1368"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_3_2_0"/>
    <dbReference type="OrthoDB" id="1626703at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="159" mass="18081" checksum="1AD06E755A419B16" modified="2012-07-11" version="1">MKTNPSVPNGEELLKLDNQLCFALYSSSRGITRLYRPVLSEFGITYPQYLVMLVLWEKEPLTVKELGERLFLDSGTLTPLLKRMEKLGLLTRERSQGDERHVIIGLTNKGKEMREKALSIPLRIANQVNISEAEFASLMASLRKLMKKIDMDDSKASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F561</accession>
    <name>I2F561_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">buk</name>
        <name evidence="10" type="ORF">Theba_1376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731010.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1376"/>
    <dbReference type="EnsemblBacteria" id="AFK07064">
        <property type="protein sequence ID" value="AFK07064"/>
        <property type="gene ID" value="Theba_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1376"/>
    <dbReference type="eggNOG" id="COG3426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048716_0_0_0"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="361" mass="39547" checksum="DF1365D9B8201004" modified="2012-07-11" version="1" precursor="true">MSVVLVINPGSTSTKLALFRDSEMIGEHTIRHSPDELSKFPSLYEQREFRKALIVRFLESVKHPLSEIDAIIGRGGMLRPLEGGTYAVNEEMIEDLRLAKYGEHASNLGAILANELSLESGKGIPAYIADPVVVDEMEPVAKFSGHPDYTRRSIFHALNQKAVAREVASRYGKKYEEMNFVVVHMGGGISIGAHRRGRVVDVNNALNGDGPFSPERAGTLPLTGLIKLCFSNEYTKDEIRKLIKGKGGLMAYTGTSDCQKVQQAILDGDRESELAYKAMAYQIVKWVGRMAAALSGEVDAIIITGGIAYDSRFMVPWLTEKLSFIAPINVVPGGNEELSLAVACLRVLEGSEKAKQYRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A7</accession>
    <name>I2F5A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731055.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1424"/>
    <dbReference type="EnsemblBacteria" id="AFK07110">
        <property type="protein sequence ID" value="AFK07110"/>
        <property type="gene ID" value="Theba_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1424"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_62_1_0"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="426" mass="46369" checksum="B4E3AA06A556C6F6" modified="2012-07-11" version="1" precursor="true">MSEREAMISNNKGKIPVYCLLVSAYFFSYFFRVSASVSLPAISTEWGMSASLVGFISSLYFYAYAFMQPISGALNDRFGPLRIVSLGMLTTGIGALLFGFASNPTMLGVGRLLTGFGLAPMLSGVLVYQSHSFHRDKYSFFSGITYTLGNFGAVISVAPLAFALDKFGRRNVFVFLAFLNFALAASLIAFRRRDPVISIDGKIERKGFLDNLKNSFRKILRSRQLKLMLVLWGTSFGALMSLQGLWAVSWYQTSYGVSYGTASLWSTLISIGVMVGNFVGAYIARPARLRLPAITVSCVSYGASWVFFWFSMRSRLPILIPGLVGFFLGFFAGITYDHLTAGVNDLAARGRGGSLFGGMNLFTFISVIIFQSGTGFLMQRFSSSGGAEIDLAAFNSTFGIVTLLVIISLVALPFLKSFSGQGGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D4</accession>
    <name>I2F5D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486983.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1451"/>
    <dbReference type="EnsemblBacteria" id="AFK07137">
        <property type="protein sequence ID" value="AFK07137"/>
        <property type="gene ID" value="Theba_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1451"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_6_0"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="201" mass="22849" checksum="32FF660A4292D954" modified="2012-07-11" version="1">MALVYVVDDELNVRRIVKKTMENENNEVHTFVTAEEALEEIEKRKPDLLFTDISLPSMNGIQFLKELKNRGYSIPVIVISSDTSPESMRSAFKAGIVDFLTKPFTPQEIRDAAELALREEDSIYKRAREIKRLIEEGETAKAESLMGNLFSDFPGSPFPHFLYALLVAKDNPRVAIKHLKASLSLDEDFKDASDELKKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E8</accession>
    <name>I2F5E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731085.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1466"/>
    <dbReference type="EnsemblBacteria" id="AFK07151">
        <property type="protein sequence ID" value="AFK07151"/>
        <property type="gene ID" value="Theba_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1466"/>
    <dbReference type="eggNOG" id="ENOG5032T73">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309247_0_0_0"/>
    <dbReference type="OrthoDB" id="1914620at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="205" mass="23509" checksum="6A426F6B45F98ECE" modified="2012-07-11" version="1">MPLHLLVAYYVVDHAFVNNKKLAKMDDKKFWMHFVWVVLVFLAFTFDVFLSNPLGILILILSIGLTVTLDMGRKRLSNELIEIIAFFLLLFLTLLGRSFLIESFVTVEFSWYLMGMLLTTVGVTYFLRGRIIKEEATDSIGIAERMSIFIFILANQWTWVIISVAAGLAFRAVFSKEKKTEWIISPVAGVLISYLWQLLMRGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F2</accession>
    <name>I2F5F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731089.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1471"/>
    <dbReference type="EnsemblBacteria" id="AFK07155">
        <property type="protein sequence ID" value="AFK07155"/>
        <property type="gene ID" value="Theba_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1471"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_0"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="479" mass="53519" checksum="D8A4C8FD3D2FA6D5" modified="2012-07-11" version="1">MAYSLKGGRVYSVPDGRYVTRDLYISEGIISEVPAKDAIEIDVSGKFVYPGFVDSHAHLIGTGRKELEVDLENCDSVEKLETALNVERDIVRARGWDQEVLGFMPVRKILDSIISRPVIITRRCGHIASANSAFIKLFSLERLHGLDGTDIDLGILKERALDEVERNVLLTSGEVEAAIEAGTKAFLKYGVTSVHSDDYHGIEYELLMQRLAGIVDLRVYEKFCVSREEDIEMILLGRQFENEFFQLNAAKLYLDGSLGARTAAMIEPYYDSPGERGVLYKSAKEIRPIVKRADGEGIQVCVHVIGDRALEEALKAFEGSKSETLRHRLIHVQIASEEQIRRMVEEKLTASIQPVFVDSDKLIAPERFGPSRLENAYPFGKMRDMGVLLALSTDSPVESTSVIRNLNSADRYFSRRESIEMYTSNGHLLANSCRGCSLEPGYPADLFVIDADLLKTNEDRFSDMTFVGGRLVFSLSEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H7</accession>
    <name>I2F5H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase, carboxyltransferase component (Subunits alpha and beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731108.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1498"/>
    <dbReference type="EnsemblBacteria" id="AFK07180">
        <property type="protein sequence ID" value="AFK07180"/>
        <property type="gene ID" value="Theba_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1498"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_0"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="259"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="512" mass="55675" checksum="16ACA653B0806B54" modified="2012-07-11" version="1">MTGRLEEFFEKSEKITLGGGQDKIEKHHKSGKLTARERIDALCDEGSFEEFDRFVKHRATSFGLENKEFPADGVITGIGTVNGRKIAVFSQDFTVQGGSLGEMHAKKIMKVQDMAMKLGIPIVGINDSGGARIQEGVDSLFGYGGIFHRNTLSSGVIPQITVICGPCAGGAVYSPAITDFIVMTDKHSQMFITGPQVIKAVTGEETSMEELGGALVHNTKSGNAHFLVPDDKNAMLLVRELLEYLPQNNSEEPLKTESTVSDPVLELREIVPDNPKQSYDIKKVISLVVDDGKFLEVHEHYAKNMVIGFARIGGRSVGIVANQPSVFAGSLDINASDKAARFIRFLDAFNLPIITFVDTPGFLPGISQEHGGIIRHGAKLLYSYSEASVQKITLILRKAYGGAYIAMGSQHLGADIVFAWPGAEIAVMGPEGAANIIFKREIDASGNPEKTRQEKIAEYKDVFANPFVAAGRGYIESIIDPAESRREIIRALETLDTKVEGRPSKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R0</accession>
    <name>I2F5R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489367.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07263">
        <property type="protein sequence ID" value="AFK07263"/>
        <property type="gene ID" value="Theba_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1597"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2423519_0_0_0"/>
    <dbReference type="OrthoDB" id="2061382at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="91" mass="10766" checksum="E7F313B93C539D27" modified="2012-07-11" version="1">MSTRLLRPTERGQITIPKEARDKLKITPDSRFKVSVEGDKIIYQLVSPFDMIVKEFQKEAEARGYTKEELENELEKVRKKLFKEIYDESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F629</accession>
    <name>I2F629_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1648</name>
        <name evidence="2" type="ORF">Theba_1725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MesG1.Ag.4.2</strain>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731206.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1648"/>
    <dbReference type="EnsemblBacteria" id="AFK07311">
        <property type="protein sequence ID" value="AFK07311"/>
        <property type="gene ID" value="Theba_1648"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07382">
        <property type="protein sequence ID" value="AFK07382"/>
        <property type="gene ID" value="Theba_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1648"/>
    <dbReference type="KEGG" id="mpg:Theba_1725"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="404" mass="45880" checksum="389DF0B0EBE1B230" modified="2012-07-11" version="1" precursor="true">MKRFLLVSLVLLAGLMVLGVTNIRISGWPGNPVEEAVIMKNVEEFNNMQTDIVVEWQPIPGDFRQMLITQYSAGTAPDLFYVEAFWFEELAKQNMLLPLDLYIKRDDSFDIDWFYPNLIEAFKYEDRIYGIPKDFSTLALVFNKKIFDQYDVAYPTDEDTWFDMLDKALQLKRKGFETPLVLAADLNRILPFVYGTGGDIVDEDLNVALGKPDAKFGLNFYLDLVNKYKVAQEPANLGAGWIGEAYGKERVAMAMTGPWTIGFLAGDYPEVLKNTGIVEMPHLIEKSTMVYTVSWSINRTTPNKDAAWEVLKFLVTKGQERFVSEAGVLASNIQNAEKDTDPTKQAFYRGAEYGTPWKVKTPSGVFSRAHDQLNSLLKDLFYQKISLSEALTFVEENYSGWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F663</accession>
    <name>I2F663_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1693</name>
        <name evidence="3" type="ORF">Theba_1760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731247.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1693"/>
    <dbReference type="EnsemblBacteria" id="AFK07353">
        <property type="protein sequence ID" value="AFK07353"/>
        <property type="gene ID" value="Theba_1693"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07416">
        <property type="protein sequence ID" value="AFK07416"/>
        <property type="gene ID" value="Theba_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1693"/>
    <dbReference type="KEGG" id="mpg:Theba_1760"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1935544_0_0_0"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="130" mass="14620" checksum="52500C465F0BC1E0" modified="2012-07-11" version="1">MVKYSLNWIGENIFVNLEINVLKALADNTRYEIIKLLLRREFCVRALSRRLGISEPAVSQHLKVLRSAHLVKGHKKGYFTHYSVDRGKLKELSNQLAELCEESSDTLLSDSIAILQESISGSLDSSGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D2</accession>
    <name>I2F6D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488381.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1834"/>
    <dbReference type="EnsemblBacteria" id="AFK07485">
        <property type="protein sequence ID" value="AFK07485"/>
        <property type="gene ID" value="Theba_1834"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1834"/>
    <dbReference type="HOGENOM" id="CLU_1957001_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="128" mass="14155" checksum="291915C8339D4AED" modified="2012-07-11" version="1">MSCKEIRAYCFGDQCPWNSVALEQARKAADSLGLNFVKFDLSGTISDLPLFFPFTLIYSDLKIAGPVSSDFIVDVLEGRKTVRPFGDAKRRPAKNCDRIETLSRESLRDACLVCTNGTGNGSEKNRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E4</accession>
    <name>I2F6E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+ transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488344.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1847"/>
    <dbReference type="EnsemblBacteria" id="AFK07497">
        <property type="protein sequence ID" value="AFK07497"/>
        <property type="gene ID" value="Theba_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1847"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_0_1_0"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658685" evidence="2">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="326" mass="36064" checksum="31C5A443BEA0DFE2" modified="2012-07-11" version="1" precursor="true">MKRVLISVIFLVFFASAFANLVVYSSVDEANARKILNAFVEDTGIEVDFVFLSSGPALARIEAESSNPQADVWFGAPLENHIIAKERGLTQAYKTLSVYGVSPEFYDVEGYYHPIYMNPLGVGVNTSVLEQIKASLPESWEDLLASEYRRMIQYPNPQSSGTAYSLITGLVKIYGEDGAFQYLKNLAPNIQTYTQSGTGPSKAVGPGQVALGIQFTPAFFQFMEQGYPVSVVFPKEGVPYEVASVSILKGAKNLADAQKLIDWVVSKAGQQQIVDQKTYFYPIRPDVDFGSLQPLSTINLLSIDPAWAAENKTRLIERWINEVLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G4</accession>
    <name>I2F6G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type (Unclassified) transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488303.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1867"/>
    <dbReference type="EnsemblBacteria" id="AFK07517">
        <property type="protein sequence ID" value="AFK07517"/>
        <property type="gene ID" value="Theba_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1867"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="240" mass="26323" checksum="6EA53401CA69A51B" modified="2012-07-11" version="1">MSDPSYLKCEHLDKRYGKRRVLKDVSLEASSLEVVGLLGPNGAGKTTAFKSILGIVIPNSGSIFLDGENITHLPIHERAKRGIAYLPQETSIFRGLKVIENLTMVMKLTGQEDKCLEKASEILDEFGILSLKDQTASLISGGEKRRLEFARTMTLSPSFILLDEPFVGIDPMTVKDIQKMIRKLKSRGIGVIVTDHDVSSIAKVVDRLYVLYKGEVISSGDPAAVLGDSLVVEKYLGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H4</accession>
    <name>I2F6H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488284.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1877"/>
    <dbReference type="EnsemblBacteria" id="AFK07527">
        <property type="protein sequence ID" value="AFK07527"/>
        <property type="gene ID" value="Theba_1877"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1877"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_2_0"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="218" mass="24703" checksum="5EADF4B43C0A74C2" modified="2012-07-11" version="1">MIRAVIFDMDGVIIDSEKLYRRACTELVSELGGKISDELFEKQMGLKMSQTQRVIVQTAGLDMEPEEFGRRYMERYLELARETVVPNIGLIELLDFLYGKVELAIASSTEKSAVEELMKKINVLEYFSVIVGGDEVRESKPSPMIYQRASRLLGIAPEDCIVIEDSPNGIRSGFMAGMEVLGVRHEENIDLDLSLSKHVFDNLNGVREYLEKRFDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I7</accession>
    <name>I2F6I7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">Theba_1892</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731342.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1892"/>
    <dbReference type="EnsemblBacteria" id="AFK07540">
        <property type="protein sequence ID" value="AFK07540"/>
        <property type="gene ID" value="Theba_1892"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1892"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_0"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK07540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="26951" checksum="DA91019AC13F0AE2" modified="2012-07-11" version="1">MVMYNFSMKSAKRDLSELVRFDAAYRADHRVIAGVDEAGRGPLAGPVVAAAVIVLNPVDGVYDSKALCRKTRELLFGQILENSIVGIGLCSPEEVDILNVFAATRLAMNRALRILSRKPDYVIVDGKSLRLDISGECIVGGDRRSAAIASASIVAKVFRDRIMDSLDILYPEYGYRNHKGYCTDMHLRALRKYGPTTWHRLTFRPVRELITKERASRWSNESEVSLIRLFRAGLATMEADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N3</accession>
    <name>I2F6N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1941"/>
    <dbReference type="EnsemblBacteria" id="AFK07586">
        <property type="protein sequence ID" value="AFK07586"/>
        <property type="gene ID" value="Theba_1941"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1941"/>
    <dbReference type="eggNOG" id="COG1237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_0"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="33718" checksum="704DDA14BD8D17D5" modified="2012-07-11" version="1">MISEIRVDWFFPLVRTSEVWINLWLGEEIKPPIAERRINMKITVLCNDKGLEGFESEHGISFFIELNGKKFLFDTGSTDVAVKNAGKLGIDLSEVESIIISHGHYDHLGGLGNVLKKTGAKKVMVGEGCLERKFSGSTESSPEGFGSEYERLGASIETVRASREITNGLHVMTAAPFVTEERPGDKHNRIKGGTRIRDFFEDELSLAVVQNGVVTVITGCSHRGIGNIVKQASGFGKVKNVVGGLHLLHKTEDELEEIFEYLLGFDIDKFHIGHCTGDNVVKKIAERFPAEVRELMAGDSFEFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P5</accession>
    <name>I2F6P5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731394.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1953"/>
    <dbReference type="EnsemblBacteria" id="AFK07598">
        <property type="protein sequence ID" value="AFK07598"/>
        <property type="gene ID" value="Theba_1953"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1953"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_1_0"/>
    <dbReference type="OrthoDB" id="871298at2"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="38513" checksum="62E715ED5E6A083B" modified="2012-07-11" version="1">MALGVDRITNTVYVESNSFDPWLNLAIEEYLLNSYARDSSVLYLWQNEKTVVIGRNQNAWQECRLDNLERDGGRLARRLSGGGAVYHDLGNLNFTFLMPRKEYNLHRQLSVIVDAVKELGIEAHFSGRNDILAGGKKFSGNAFYHGQFASYHHGTILIDVDTGKLSEYLNVSKEKIESKGVKSVVSRVVNLKEMKPDLTIDTMKKAMYRGFIEEYGQIVSVLDFERVIESEDIGDLYEKYSSKEWLLGRNPEFNFRASKRFQWGGIELLFTSRKGKIVDVTVYSDSMDVDFIEELRRGLKNIEFSRSSILKALNNLPRYIERDDIINWLGITDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z0</accession>
    <name>I2F6Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-grasp enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731473.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2052"/>
    <dbReference type="EnsemblBacteria" id="AFK07693">
        <property type="protein sequence ID" value="AFK07693"/>
        <property type="gene ID" value="Theba_2052"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2052"/>
    <dbReference type="eggNOG" id="COG3919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034084_2_1_0"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="117"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="402" mass="45195" checksum="CCBCFD8ECF6B8FA2" modified="2012-07-11" version="1" precursor="true">MRVLVTGARMWYAINTIRLLARSGHEVFAADSSRLSGGLYSRYLKGKFIYPSVGENSSAFVESVIEKIEELKIDVLCPTFEEGFVFSKYIGRLEGRVNVLVPSYDHITLLHDKYSMTTYARSLGISVPKTALLKDFSLEGCEFPVIIKPRNQRSAEGIFKVNSIGEFEKRCRNLEEDRYLVQEWKEPYQICTTGLAHNGRLIGNVIYHNIREYPESGGIGTCRVSIDCEKALGEVKKIVSDLNYSGFISMDFLHDRINGEYYLVDVNPRMSPGLLIAYNSGVDMVKAYLELANGSEVSVARSPKTGYGTFTTAMEIGWFFSTLFKGKFKNLKGFFKSRKKLKDDSWDVRDPIPFFVMLLSMLNTAVFGPLRGGQTKSFSLGATCDTESLGSEDELIKKKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z4</accession>
    <name>I2F6Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFK07697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07697">
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        <property type="gene ID" value="Theba_2058"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2058"/>
    <dbReference type="HOGENOM" id="CLU_3201876_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="45" mass="4916" checksum="4EB581EA1849D2CF" modified="2012-07-11" version="1">MRFLNKTVLVTGGAKGIGKAIFIGFARCGAFVLIMDIMWKLGIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F709</accession>
    <name>I2F709_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Chagasin family peptidase inhibitor I42</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_2075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07712.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2075"/>
    <dbReference type="EnsemblBacteria" id="AFK07712">
        <property type="protein sequence ID" value="AFK07712"/>
        <property type="gene ID" value="Theba_2075"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09394">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I42" evidence="1">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I42" evidence="1">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="224" mass="25030" checksum="BED315229F5BACC4" modified="2012-07-11" version="1" precursor="true">MKKALTAFFYIALIITLGLAIELKESANSMSVNDLAILEIQENPSTGYLWHIFAEPTGVLRNFLEEHNTRSIMPGAPSVKGWIMTAAKEGKALITLKLFRQWEGEKHSVDFRALTVDVTGQGKGQVDLKILTNEVTLGTIFTVTLEENASTGYTWQYVVLGDGIMEKNKEISVDKSDKVGAPSKVTWTFQAVDEGYSTIIFRYFRSWEGKESAVDYKAYNISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F731</accession>
    <name>I2F731_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Membrane complex biogenesis protein, BtpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07734">
        <property type="protein sequence ID" value="AFK07734"/>
        <property type="gene ID" value="Theba_2100"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075239_1_0_0"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="30892" checksum="E7669338BC5FE0C8" modified="2012-07-11" version="1">MRRDREVLSSIFKKGKPIIGMIHLRPLPGSPRYDPEKLGMKEILRIAIEEARIMEGCGVDGLQIENIWDFPYLKGERIGHETSAALAVATQSVREAVNIPVGVNCHLNGGKAALAAAVAGGAKWIRIFEWVNAYVSHAGLTEGIGAELSRYRKLIGAEEIKFMCDVNVKHGSHFIISDRSVEEQAHDAESEGAEILIVTGFETGQAPNAEKVKSFSEAVSIPVMIGSGLTKENVGELLRFADGAIVGSYFKRDNNWKNPVDPNNVRSFMKTVESLREAGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F744</accession>
    <name>I2F744_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Theba_2113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFK07747">
        <property type="protein sequence ID" value="AFK07747"/>
        <property type="gene ID" value="Theba_2113"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1892901at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
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    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
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        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="274" mass="30135" checksum="3BA9409A71924C00" modified="2012-07-11" version="1">MNKLIITAALTGAEVMKDQQPALPISPEEIADAAYDCFLSGASIVHIHARDSSGKPTQNLEVYREIKERIAEKCDLIFQPSTGGAVWHKVRERAQPLELNPEMATLSAGTCNFGEDVFFNSQDTMETFAQEMKARGIKPEIEVFERGMIENALKLLKKGLIDSPIHFDFVLGVPGACPGNIEDLIHMVRAIPQGSTWTVAGIGRNELVLATAAILLGGHVRVGFEDNIYYKKGELAISNAQLVERVVRISNELGRDVASPEEAREILGIRRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F750</accession>
    <name>I2F750_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731523.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07753">
        <property type="protein sequence ID" value="AFK07753"/>
        <property type="gene ID" value="Theba_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2119"/>
    <dbReference type="HOGENOM" id="CLU_1576657_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="18312" checksum="CCA46F39DDE1E3E4" modified="2012-07-11" version="1">MAWIILSRCKPPPMSVQGGFWKKGSRFIQRHTQELRLLVVSEVSMDMSVFQRVPLPDTRLFILIPAPLVLLRGVIAIENIAVGVLFTGGISFSLFSFGGLAFSILLSLGGVSSSLIFTLGGLAFSLCFAAGGLVASYDLALGGMAIARNYATEVFQWQMLPLEKTPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F763</accession>
    <name>I2F763_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2132"/>
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    </dbReference>
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        <property type="entry name" value="SBP_5"/>
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        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657673" evidence="1">
        <location>
            <begin position="20"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="222"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="695" mass="78183" checksum="7D30DE9DC380DD48" modified="2012-07-11" version="1" precursor="true">MKKLFVCMLVLFFSGLSLAQISAEEAIPVIESRGILTSVDESPLTFTEFKAAIEKAFPGKEEIIKGKGEVSRADFAVAMVEVLGLQSEAEAFDEICTTALDEWEAPEEAWGALTVAYRSNRQLLDFRYGHVIEASSPITRKEAAISIYMAINPPAKGGTATTAVTADAPGFNTLFTSAGLTWTICNIIGDGVTGTDKDGFYFPRMIKRMPSLENGLMVINEDGSLTITYELRKGMKWHDGEPVTAHDAKFQWEVMNSGAPVTTNYFESSVSEVEVIDDYTYSITLPEPLSNAELGSSVYAYYFGWFQLPEHVFRDSYEEAKHSGSWDSFVENATKNPIMTGPYKLKEYVEGQYVIMEAFDEYYMDRPNIDQLVMRIIPDMDVVFASTLNGEIDFGRYTLTLKQSVQLENERADMFNVFYTPNIAYDNLNLNLRDPEDTSKPHPIFGDKRVRQAVLYGLNREQISNVVYAGLAEVVDTWITDLHQMRDALKSPEVKHYEYNPAKAKALLEEAGWKLNSKGIYEKDGTPLKFSLSLASGSGDYQMMAQMIQGMLKQIGMEVEIEVMPALVIWTEIFPYGDFDAHISGWGYGVSDEAANYWTTDQIPSEENYWGGMNFTGWANAENDEIVNAAARELDPEKKLALYEKHFALWTEELPVLPLVVAPTPHFAKKYIKSFNSGYDNGLGWIIQNWYIDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C5</accession>
    <name>I2F7C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731591.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2195"/>
    <dbReference type="EnsemblBacteria" id="AFK07828">
        <property type="protein sequence ID" value="AFK07828"/>
        <property type="gene ID" value="Theba_2195"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2195"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_5_0"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="49"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="33549" checksum="37E1D6018CCF4B60" modified="2012-07-11" version="1" precursor="true">MVKFLAKEVSVLKRALTVGLVVLFAALSAAIDIVDDLGRLVTINEPPERVVVASPAITKYLEVLDLSSRIVGVTDWDPFALSNEVEKIGNLVPLNLEKIVSLSPDLVMISGGFQEAEVEKLENIGVNTYVMNPNSFEDIYRNLVVVGNIFGVPERGKTSADDFREEVLAIAKDSHKLSQDEKPRVIYIMIAGEVSDIWTCGTGSFVNQAIAFAGGANVAAPYSGNNGWFPVSPEFVLNSQPEIILVPYYYEGGQEEAVNMIVSYKPFEELPAVKNDRVYPLYDGLTAYANPNFVNLVKTLKEFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D7</accession>
    <name>I2F7D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ORF">Theba_2208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731601.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2208"/>
    <dbReference type="EnsemblBacteria" id="AFK07840">
        <property type="protein sequence ID" value="AFK07840"/>
        <property type="gene ID" value="Theba_2208"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2208"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_0"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="318"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="569" mass="63113" checksum="CF43689FE69CBE23" modified="2012-07-11" version="1">MIVRTALAQINTTVGDINGNKNKIIEAIDQATASDSEILLFPELTITGYPPEDLLLNTGFLRENLAALKEIANYTEGSKTMIVLGFVDFSNEIYNAAAVIHSGEIRAVYRKMSLPNYSVFDERRYFSPGSHPLLARYGEANIGINICEDLWVPSGPINEQAIGGANLILNLSASPFSGMKSKTRSALLLTRAMEYSSIIVYVNLVGGQDDLVFDGRSCVAMPDGRLLLGKAFEEDMILLDIDTDVSTRYNLFEGKRKDYSMQVSLEEVSITPSHRQSPSVNPDSSCQELCKYDELIAALEIGIRDYVKKNGFKKVVLGLSGGMDSSLVAALAVRAIGNDNVKGVMMPSRITSGESKRDALELVNNLQIEGLEIPIDDIMCTTLSTLEPVFTGTSEDITEENLQARIRGMILMALSNKFGWLVLITGNKSEMATGYATLYGDMAGGFAVLKDLYKTQVYRIAERINELAKRDMIPRNVFSKAPSAELREGQKDQDSLPPYEILDEILRLHIEEGQSAEEIVLEGFERDTVEHSLKLLRRSEYKRKQCPPGIKVSKRAFGKDWRMPITNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F9</accession>
    <name>I2F7F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731621.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2232"/>
    <dbReference type="EnsemblBacteria" id="AFK07862">
        <property type="protein sequence ID" value="AFK07862"/>
        <property type="gene ID" value="Theba_2232"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2232"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010060_2_0_0"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658414" evidence="3">
        <location>
            <begin position="24"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="450"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="648" mass="73676" checksum="A30B1A9F87275EFC" modified="2012-07-11" version="1" precursor="true">MRSTTIILTLVFLAVSLSTSALANPDHVLTVDPSSLGPEVSSLLYGIFFEDINHAVDGGLYAEMIRNRSFEHQDPVEGWFAVFESDCKATFSIETDRPLNKNNTKYLSFEIQSDDKLISLSNDGYDGIPLKKGERYLFSVFVRSDEEYNGEIKVMLANAKGEPEAEKNLGTAFSSEWEKYSVELQPNEGLDDGRLIITMKGSGKISFDMVSLFPEENWNGMRIDLLEMLEELKPAFVRFPGGCLVEGDSLENAYRWKDTIGPIEERKTNYNLWGYHQSYGIGFYEYLLLSEHLGAEPIPIFNAGMSCQVRGAEYCPMDEMDEWVRNVLDFIEFANGPSDSLWGSKRSELGHPEPFNIKYIGIGNENWGTEYHDRFPLFRQAVKEKYPEITIIFSGPPSYEGASFNRAWRWARSNGIEILDEHMYAVPEWMLRNTDRYDKYDRSGPKVMLGEYAAHAAGTRNTLQAAIAEAALMTGLERNSDIVIMAAYAPLFNREGWSQWTPDLIWFDNTRVYGTPSYHVQKLFNDNTGNVIISSSLTDEDIEIIGYWFKSLYHVCSYDFESKELIIKIVNPWPEEKKLRIEIGEEVQVTGKAEMISITSDNIFDENTFQNPDKVRPKTVGMSNLSNEFTLTFSGNSVTVLRLETTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H3</accession>
    <name>I2F7H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731635.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2247"/>
    <dbReference type="EnsemblBacteria" id="AFK07876">
        <property type="protein sequence ID" value="AFK07876"/>
        <property type="gene ID" value="Theba_2247"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2247"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="34662" checksum="0D523DBF2F830831" modified="2012-07-11" version="1" precursor="true">MILFKAGSKGPAFLAMGDRMKLKQKTKGFAYILPALVFIVVIFMIPLTYTVVMSFLRWNLLRPDLGIKPAGFTNYVRLFTDSFTLDTVGRTFYFVVGAVLVELIIGLCIALALDTEFKGWKIVQSILLVPFMIAPVVVGYVWRFVLNSDYGPIIHLMKQIGFGGLVDKPLLSNPSAAMPVLIVADAWEYIPFVTLVLLAGLKSVPYEPYEAAFVDGASSIQRFFYITLPLLRPSILVAVVIRTLTSLRVFDIVFIMTGGGPGTATETLAFYGYRTAFQAYNVGFSSAINMLTFGIAVVFTILYMKIIGGGKNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q1</accession>
    <name>I2F7Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2328"/>
    <dbReference type="EnsemblBacteria" id="AFK07954">
        <property type="protein sequence ID" value="AFK07954"/>
        <property type="gene ID" value="Theba_2328"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2328"/>
    <dbReference type="HOGENOM" id="CLU_2409824_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="92" mass="11106" checksum="CB37F0920C5554C6" modified="2012-07-11" version="1">MKTELAKPRRSSRLEILRRTKTSYSIYSLHLTETKRNDPENARILFCFFNDKKVIVYLVFFDESDEKYEKAIERLKSRICEWTGRGFNVCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R3</accession>
    <name>I2F7R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc dependent phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731716.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2341"/>
    <dbReference type="EnsemblBacteria" id="AFK07966">
        <property type="protein sequence ID" value="AFK07966"/>
        <property type="gene ID" value="Theba_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2341"/>
    <dbReference type="eggNOG" id="ENOG5032KU4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862966_0_0_0"/>
    <dbReference type="OrthoDB" id="1842762at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004629">
        <property type="term" value="F:phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11009">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001531">
        <property type="entry name" value="Zn_PLipaseC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658425" evidence="1">
        <location>
            <begin position="24"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="39101" checksum="56B44EF739EF6D32" modified="2012-07-11" version="1" precursor="true">MKRVMVILTLLLTAFAFSWSGHDALTYIIVSQYEDDFDAFVEITPYTYSDVDTQQYNPAIEGFYDYLGEDYLPEEDLDLYSSIFPNPKPVDNLAPLWQILSVYSYEPDLGMDKGLELKGIETLLGDSQGLRHMEYRMLFFIRVGKVTDVVQYFSDLAEIAYSRGDHYWAYRFLGRALHYLEDVGQPFHTFPAPFFELLKLPFNMDKWLTVFANYHFAYDFYGGYLLWEEYEPLVEAIKEVSPKEIKDPKQAAVSLRRYSRNRLSSVYYELKRTMGDKLENPESAWPGKAYFDDLQDAGETAKLDALSVEILRETASYVKGYINYMLARFAEIDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S0</accession>
    <name>I2F7S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490054.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2348"/>
    <dbReference type="EnsemblBacteria" id="AFK07973">
        <property type="protein sequence ID" value="AFK07973"/>
        <property type="gene ID" value="Theba_2348"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2348"/>
    <dbReference type="eggNOG" id="COG5061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072282_0_0_0"/>
    <dbReference type="OrthoDB" id="1452951at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="29417" checksum="070AC0623F260456" modified="2012-07-11" version="1" precursor="true">MNGFMIPLALSILAHVLADFLFQTDNTAKEKSEQQAKGFLKHWIVVFLTLLVLMMPFGLMDVLLYCVVLSLFHILLDVFKSSIESKRGPATRFSMFIIDQLLHLMLIVFLVPISSFTIARSFSAFIVWIDFHTGLDLAVLPVSKMLSVLIVYLYVLFAGAVFIRKLFDLIYKNQPDYLERIVGNSSSLDNVRTGKAIGIFERLLVLTLYLTGNVASITIVIAAKSLARFKNFDNKDFAEYYLIGTLASVMIAIIGGMILEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X7</accession>
    <name>I2F7X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731770.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2414"/>
    <dbReference type="EnsemblBacteria" id="AFK08030">
        <property type="protein sequence ID" value="AFK08030"/>
        <property type="gene ID" value="Theba_2414"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2414"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_0_0"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="82"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="34262" checksum="2AA3E623BC64DFC5" modified="2012-07-11" version="1" precursor="true">MTVIILVLIVVGFLGIVGAVFANKVTKPRQIPYEETYRIEVENGRMDPEWFEKIEKEEVWIDSPYGYKLHGLLIPNDNSERAVIICHGITYSLFGSIKYAKIFHKLGFNIIVYDHRNHGKSGGTNTTLGYYEKHDLAAVKNWVLDRLGKKTRIGLHGESMGAAIAIQYLSLDDEIDFCVADCGFSDLEELLSIRLREDFHLPRVPFIWLARLFARIMTGADLKEVSPIRSVRETSIPIMFAHGGEDHYVPTFMSEKMYSERQSNKHLLIVPDAGHAMALVTDPAKYEKEIEWFLRSNDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y4</accession>
    <name>I2F7Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731775.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08037">
        <property type="protein sequence ID" value="AFK08037"/>
        <property type="gene ID" value="Theba_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2421"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_1_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="49029" checksum="E360B679E4059BD1" modified="2012-07-11" version="1">MKYYSLIDKVYLEKNLLEAYGRVKSNRGAPGIDGVSVETFGEKLLEEIERLSGEIKRGEYKPMSLRGVEIPKADGKTRQLRIPAVRDRVVQQSLKEVLEPIFEEGFHPSSYGYRKGRNAWQAVEKAKAFASKYGLCNVVELDLSECFDTLDHEKIIDSVAERVSDGKILKLIRAILKSGVMEDGVWKETETGSPQGGVISPLLANIYLNEFDQKMKARGIRIVRYADDILIFSKTQEEAREFLAIAINILEIDMKLKVNRNKTRITTLEDGFHFLGFEIKGERVGIEKSRLKRFKEKVRKLTRRNQSRPVKEIVKQLNPLLRGFASYFRIVDFQSILRGLLSWIRRRLRAIILHQWKTTKKLNRVLRRNGWKEKVNMRMNKWRSSHSKAANYAIPNRFFEEMNLVDMTKYHHPLSKFPILDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F805</accession>
    <name>I2F805_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731793.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08058">
        <property type="protein sequence ID" value="AFK08058"/>
        <property type="gene ID" value="Theba_2445"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2445"/>
    <dbReference type="HOGENOM" id="CLU_2955213_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="59" mass="6769" checksum="FF745D40B605E982" modified="2012-07-11" version="1" precursor="true">MRKMRRDRFYKTVLIVFTIGLAIAVMTMVIALINLTDANTSSKAFREYLDESNVIESNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F844</accession>
    <name>I2F844_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731829.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2486"/>
    <dbReference type="EnsemblBacteria" id="AFK08097">
        <property type="protein sequence ID" value="AFK08097"/>
        <property type="gene ID" value="Theba_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2486"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="338" mass="37781" checksum="585D257934988B17" modified="2012-07-11" version="1">MATIKDVAKLAGVSISTVSYVLNNSNRIGEETRQKVLKAAKELNYVPNTFARSLKKEKYDLVSLIVHEIKGPFYDSLVKGIQDVLHNMGYNLLIYCTLENRRQDVAKFLKNDIVDGLIIMTPTVKSEDIEGFSRDFPVVTLDRVLKSERVRSVRIGNERGSYEVVRHLHELGHRRIGFIKGSKDTLDARERYSGFTGAMKKFGLNVVAGDVLEGDFTEESGRSSMSGYLEANRGRKIATAFYCANDETAIGALKAINEYGLRVPEDISLVGFDDIELSSYITPKLTTVRRPMYQLGSLAAHMLISLIFGKYDEVSNINLDVTLVVRDSTGRAAHEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F855</accession>
    <name>I2F855_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731840.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2500"/>
    <dbReference type="EnsemblBacteria" id="AFK08108">
        <property type="protein sequence ID" value="AFK08108"/>
        <property type="gene ID" value="Theba_2500"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2500"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083245_0_0_0"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="235" mass="26893" checksum="32425BAE7E34EE11" modified="2012-07-11" version="1">MNTVVCIGDSITYGRVGVSYFEMLKSEFGGKYRFINSGINGNLSYDVLKRIDGVTSLKPDIAVLLVGTNDVWATYSEKTMKAYIRKNRLPERPSKESYARNFAEILQRLKTASIAHIGVMSLPLITEEPEHILFKRSVEYSELIKKITSQMDLCYIDLNERQRDYLTKNKKSPSSGREVSWEFTLRIIFKHILLRKSWDALSQENGFLLTVDHVHQNSTGAALIKDCASEFLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F878</accession>
    <name>I2F878_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489550.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08131">
        <property type="protein sequence ID" value="AFK08131"/>
        <property type="gene ID" value="Theba_2527"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2527"/>
    <dbReference type="eggNOG" id="ENOG502Z8M2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665429_0_0_0"/>
    <dbReference type="OrthoDB" id="565785at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="47980" checksum="0ED8A474AFD5E2ED" modified="2012-07-11" version="1">MNDGRTKVGIGFATGRRHFQRVLRSYVYNWKESELVDSRELTLNLFVAYDLNYKNTKKANYTKISSGVDELLFSKHFIGQKEVEEEKRELIKRGIVDSEEASLVFGKGYASQRNIVLYSALKNHIDCLLYLDDDEYPVAVTNDMGSVSWMGQHLLKTHLNYIDQADITYGYHCGYISPIPFIEFSPALPEDTFRLFIEAISNDIVKWETLKRLIVAGGVSYADPKILNSGEVFEVEEVNHAKFISGSNLCLNLKDPGRLFPFYNPPGARGEDTFLSTCLSDRRVLKVPSHAFHNAFSTYNHILMGVLPTSLRPIRADSRDIVRRFYRSCIGWIRYKPLLLYITDRNNYSKKIEEMKINLRETLPSISSYFGTDSFYNISKELNKYHKSVEKHYEQFERVKEIWSKISDYLREAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F897</accession>
    <name>I2F897_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731875.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2549"/>
    <dbReference type="EnsemblBacteria" id="AFK08150">
        <property type="protein sequence ID" value="AFK08150"/>
        <property type="gene ID" value="Theba_2549"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2549"/>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_0"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="42"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="369" mass="40814" checksum="3FBC1CAFCD64B968" modified="2012-07-11" version="1">MRFENVLVVDPIDGEFVGSVEIQENVISEIKRVQGTQEFERILMPGFVDPHTHGSVGVDTLSMSQKDLEKWENFLYSQGVTYFLPTTMSSTPSAILSAARVVRDYIKNNSMTSVGGIHYEGPYLSLKRKGAQNPELIRSIDLKEIEETLIESVKLITMAPELEGFSHAQEMIQKRGITLSLGHTDATYEDMERAYNQGCDRITHFPNGMNTLHHRELGCVGAVLSLPFSVEMIMDGIHSLPGFVKLIFGIKGAEKIMIVTDTIDATAMPDGEYELGGQKVILKNGRPTLEDGTIAAAVLVFSGAVRNFREFTDCTLKELAMVSSLNALNSMGIKDRGRISKGYRADLVLLDETLEVQETILNGKTVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C1</accession>
    <name>I2F8C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pheromone shutdown-related protein TraB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489455.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08174">
        <property type="protein sequence ID" value="AFK08174"/>
        <property type="gene ID" value="Theba_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2574"/>
    <dbReference type="eggNOG" id="COG1916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032780_1_0_0"/>
    <dbReference type="OrthoDB" id="639131at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005230">
        <property type="entry name" value="TraB_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PTHR21530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00261">
        <property type="entry name" value="traB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="389" mass="42863" checksum="FC3A642EED9674F5" modified="2012-07-11" version="1">MSETVHRIMLDDKELIIIGTAHVSKNSAEEVKAIIEEEKPDSVAIELCNSRYQSIQDQDKWKKTDIAKVVKEKKSFLLLANLILSSYQKRMAKQIGIQAGQEMLQAIESAKETGAELVLADRDIQVTFARIWGNLGFWGKTKLFFTLVLSIFSDEKITEEDLEKMKSGDMLTSALSELAKSFPQLKESLIDERDKYLAQKIKTAPGKKVVAVVGAGHVPGLKEAIKEDQDLVALTKIPPKKKTGKIIGWTISIAIIALIVSTLIVNRDAGFDQILSWILWNGSLSALGTLIAFGHPLSILTAFFVAPVSSLNPLLAAGWFAGLVEAIVRKPKVSDFENLNEDVNSFKGFWRNRVTKILLIVVFANVGSSVGTFIGGAEVVRIFINSFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D3</accession>
    <name>I2F8D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731902.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2586"/>
    <dbReference type="EnsemblBacteria" id="AFK08186">
        <property type="protein sequence ID" value="AFK08186"/>
        <property type="gene ID" value="Theba_2586"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2586"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_4_0"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="137" mass="15674" checksum="AF8F9B29D1DEB6A0" modified="2012-07-11" version="1">MKINKFFHVAVEVPDLDKALEFYIGLLGLKLVNREKLPEKKLEVAFVAGEGCEIELMCYEDSKERKFAPESQSHFQHLSFVVDDIEKAMDYLKSNGIELESPDPIPVFDGKVFYNTFKGPGGELLEIAEEKRPRLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K5</accession>
    <name>I2F8K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly-gamma-glutamate synthase PgsB/CapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487265.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2659"/>
    <dbReference type="EnsemblBacteria" id="AFK08258">
        <property type="protein sequence ID" value="AFK08258"/>
        <property type="gene ID" value="Theba_2659"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2659"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041144_0_0_0"/>
    <dbReference type="OrthoDB" id="362744at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008337">
        <property type="entry name" value="Capsule_biosynth_CapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01758">
        <property type="entry name" value="CAPSULEPROTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04012">
        <property type="entry name" value="poly_gGlu_PgsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="38"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="367" mass="40444" checksum="C896573E9221BEAC" modified="2012-07-11" version="1" precursor="true">MNNIILAGTALLILLSALLAENIISRKRRARLKFVVQVNGTRGKSETVRLIHGALKANGFRVLGKTTGTVPLWITPEGKHVEIIRHGPANIQEQFLALRKSRRDKCDALVVECMAIKPEMQLASGRILDADITVITNTFPDHIEEIGSTEEETASVLSLSIAPGKACIVGSVSPEAYEKVRKTCEKIETKLIVAATSTEYLSGFKFIPHDENLSITIKAAELLGLDRSLAIEGMKEVLPDVGTFRYLKLGGKMGNAILANAFAANDLHSTSLLLEKVMRDFPEKEIIGFFNSRDDRPDRAAIFETMIRSFDRTIVKGPLPRRILNSKNVEKLDDPSQLDSLLDGSELVFGFGNIRGLVNWLNGLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R0</accession>
    <name>I2F8R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_2715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732006.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2715"/>
    <dbReference type="EnsemblBacteria" id="AFK08313">
        <property type="protein sequence ID" value="AFK08313"/>
        <property type="gene ID" value="Theba_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2715"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_6_1_0"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK08313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="195" mass="20970" checksum="9249D187A240C410" modified="2012-07-11" version="1" precursor="true">MFLLWTALGFLSGSIMYSKILYEKTTGKRISEIADGNPGSSNVIRGAGIILGLIAMALDYSKGYFPVLLACSIGDISGLGLVPVAISPVLGHAFSPFLGMKGGKAVAVSFGIWSGLTLWVGPTIIGVLMLFFTFILVPSTDGWKVILSMFGLLALLLVQRNLVLTLTWILNTSLLAFKHRDQLVFPIKLKFFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R5</accession>
    <name>I2F8R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732011.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2721"/>
    <dbReference type="EnsemblBacteria" id="AFK08318">
        <property type="protein sequence ID" value="AFK08318"/>
        <property type="gene ID" value="Theba_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2721"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_0"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="31192" checksum="E9460B48832FE462" modified="2012-07-11" version="1">MAYKTINGVKLYYEIRGNEEGEETVAFFNGVMASVNSWSLQSRVFERFGYRVLLHDFKGQLLSEKPEGPYTFKEHAEEARLLMKELGIEKVHLIGTSYGGEVALRFAIDFPEAVKSISIIDSVSELDEVLKLFVGGWKDAAKAGDPRKFFWNMVPTIYGDSFIRKNLKMLEERAMALEKASSDYFEGQIALYETFLGDVCMTDLLERISCRTLVVCGEEDILKPKKFSKTIADRIQKSEFAIIPDSGHVTIFEKPDVLNSLLLGFIMKNSNLHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K6</accession>
    <name>I2F1K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729983.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0058"/>
    <dbReference type="EnsemblBacteria" id="AFK05809">
        <property type="protein sequence ID" value="AFK05809"/>
        <property type="gene ID" value="Theba_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0058"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069346_0_0_0"/>
    <dbReference type="OrthoDB" id="667331at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="34141" checksum="378366FC93392617" modified="2012-07-11" version="1">MKDTDFTAIQVWFDQDSFGEEAFRRKMRDYVAEASLLWKGTNHIVVFPEFFATFLYPSFRKLSFEETTAKTLVKYAIKNMGLSFNPFKKAFLRDALVIEAYYHDVFEGIAKEFGTYLLAPSILLPVIDTESEKGRFIRGDKLYNLAYFYNPSGKVVARAFKHNLTKAESSIIFSRGQQELNVVHTEIGVIGIAICYDMFFQSEIEKLDAAGCETVLVPSCNFALWKGRLSDSTQERIWFRDGPIKATSGREKIRYLVNPMATGIVGRDRAQGRSSIWYGGRALAVAREFDREEILNVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N2</accession>
    <name>I2F1N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730008.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0084"/>
    <dbReference type="EnsemblBacteria" id="AFK05835">
        <property type="protein sequence ID" value="AFK05835"/>
        <property type="gene ID" value="Theba_0084"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0084"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_0"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="224" mass="25986" checksum="F73D9D9CE145519F" modified="2012-07-11" version="1" precursor="true">MGTRINLVEDEKNLNSVLTSYLEKEGWEVKSFKNGSDAFDEIDDSPDIWILDIMLPGIDGFELLREIRKRDSMIPVIFISARDKDIDRVVGLEMGSDDYLPKPFLPRELVIRVKKILERVHHSGGIIPIPPYKIDEARRTVTEEIDENQSQLIELTSMEFDLLLLFVNGKGKPFSRDQILDRVWGYDHYGSDRAVDDLVRRLRKKMPHFKIETVYGFGYKSVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q4</accession>
    <name>I2F1Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0108"/>
    <dbReference type="EnsemblBacteria" id="AFK05857">
        <property type="protein sequence ID" value="AFK05857"/>
        <property type="gene ID" value="Theba_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0108"/>
    <dbReference type="HOGENOM" id="CLU_1675809_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="16828" checksum="8932E3620F824A60" modified="2012-07-11" version="1">MTELGVFGVTIRCHPGLDPGSVPRTNNLDAQRRSEEPVFPKDGSMVWDEGRLFTTLSGFSAFKRASVLMLATRNRQLAAVLARAAELAARSATVLMFCITCVSWLFLPLLAVTGLSLKLRLAPRSGTNEGGAFTGGDDSRLLTGLRKQTGCSSLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U5</accession>
    <name>I2F1U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730063.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0156"/>
    <dbReference type="EnsemblBacteria" id="AFK05898">
        <property type="protein sequence ID" value="AFK05898"/>
        <property type="gene ID" value="Theba_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0156"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_3_0"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="21017" checksum="247FA254FACA964B" modified="2012-07-11" version="1">MYSENQRTAVFVPIVKICGDYHLLLTRRSTRISHPGQISFPGGHREENETLLECAVREMKEEIGALPSSLDEIYPLNVSTTVTSGKVITSFLGFIDDLKFRINKNEVEDIVFLSVKSLIMNAPEPIIMPNGKRTIRYRFPGFVVWGATARIIEASIERIIEIIENRGSGKSDYLNDHEVIHIREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V8</accession>
    <name>I2F1V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730075.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0171"/>
    <dbReference type="EnsemblBacteria" id="AFK05911">
        <property type="protein sequence ID" value="AFK05911"/>
        <property type="gene ID" value="Theba_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0171"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495139_0_0_0"/>
    <dbReference type="OrthoDB" id="297563at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="532" mass="58815" checksum="10873C8F817C6A47" modified="2012-07-11" version="1">MKILAGAIGSDIHTAGILNFLNLAGKEGYETIYIGSVIGIDKLLDSIEEASPDIVAVSYRLGKESCEGLLRELKMSLENRGIEKRLIFGGTVETAEIAERSGLFEKVFDGSEMPEEVVMFLRGRTDAKGEVDYPQTLLERITAKKPYPLIRHHIGLETVEATEGAVRNLAESGLLDIISLAPDQNCQQWFFQQENMISSEDGAGGAPFRTREDFERMYKASRIGNYPLMRCYSGTRDLLKFSLLFRETINNAWAAVPLTWYSQLDGRSDRELLEAIRDNQGAIAWNGGSGIPVEINEAHQWALRYCHASIEVTTAYLAALSAKRLGVKVYVAQYMFNTPPGISPRMDLAKALAKKELIESLKDENFTPVTMVRPGLMSLPADPDMARGQLVSSVYTAMKIDPEIVHVVAYCEATRRASDMEIIESVKMAKQAINEAIKGLPDFKQDKVIQDHKEYLKSESATIIEAMEKIKTGELTSSETIYAAIKLGILDAPGLSKMSVAKGAVRTAIIDGQSCAVDEEGKRIDEKERLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W2</accession>
    <name>I2F1W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730079.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0175"/>
    <dbReference type="EnsemblBacteria" id="AFK05915">
        <property type="protein sequence ID" value="AFK05915"/>
        <property type="gene ID" value="Theba_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0175"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_0_0_0"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="398" mass="43576" checksum="49E06A1C24660BFD" modified="2012-07-11" version="1" precursor="true">MRKRIVLLLTYTFITTITISMYRVVYNLYLREIGFSNHLIGNVTSAQLWGSAIIGLLTAVLADTIGKKKILFLSAIVVPVSGIALAFVVDPTLIIVLSFIKGGFTVTAFTVVMATMTSITKTGNRAKVFGLNFGINMASGVIGNFIGGAFGDLFGLQTTLIISMVAHLPAIIPVIRLEMTESRSKLKELFNFSGLQQDQRKVLTYYFISTATVGFGAGLFIHFGNLIFKDLFNMSATAIGIALSIAQLGTAAGSTLSHKLGKRFGALKFNLTMQLLVIPLMLSLVIVREPILFTILYAFRFVFMNITNPIMTSIIFSYVPDSKLSTVSGINGFLNNTVRAVAAMIFGFIVGTSISGYTELFLLSTAFYAANAFIIFLFYRDFKNEPRVLELYDSKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X7</accession>
    <name>I2F1X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin V acylase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05930">
        <property type="protein sequence ID" value="AFK05930"/>
        <property type="gene ID" value="Theba_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0190"/>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_1_0_0"/>
    <dbReference type="OrthoDB" id="636485at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="24"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="37318" checksum="1CD04E2E975172D8" modified="2012-07-11" version="1" precursor="true">MVVRLFFFSFFPCLAVFRFLAVKVEIVAARTLEFEFDLGSKIVVAPRDTFMTALTTGWEGLSWNVKYGYVGANSLGMDLVADGINQVGLACGGFYFTGCAGHQPLEKDLYKSTISHYDVIGWILENFATVEEVKSALDDIRVYGLTIMITESTMMPLHYIVYDAHGGCIVIEYVDGELNIHENPLGVITNNPTFDWHLQNLSNYVNLTPANIKSSKLGDFEIRATGNGTGLLGLPGDNTSPSRFVRAAFYSHGEVKPANAESAVTLAWHILNAQDIPEGLVVNEELGIVISRDIAYWSAVTDLTNRVYYYRTYEDLNIRKVELDRIDFSSGNKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y6</accession>
    <name>I2F1Y6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">Theba_0204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730102.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0204"/>
    <dbReference type="EnsemblBacteria" id="AFK05939">
        <property type="protein sequence ID" value="AFK05939"/>
        <property type="gene ID" value="Theba_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0204"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_0"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK05939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="233" mass="25206" checksum="A32B4F7857B8BD17" modified="2012-07-11" version="1">MYKRVLLKLSGEVLSGEGARGFDSERTSFLIEELRPVIEKEIQLAIVIGAGNLIRGRELSNMRGSRADELGILGTIMNALYLKEALCVNGFETIAVSSIAGISSLVEHRYDTIEDALNEGKIVVFGGGTYLPFFTTDTAAAVRAVEIGADVLIKGTKVDGVYDKDPKTNEDATKIDRTTFSEAIEKGLGIMDIEAFSICQRYGLSVRVIDFFNKGNLFDAIIGGKTGTVVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z1</accession>
    <name>I2F1Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">Theba_0209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730107.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0209"/>
    <dbReference type="EnsemblBacteria" id="AFK05944">
        <property type="protein sequence ID" value="AFK05944"/>
        <property type="gene ID" value="Theba_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0209"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_0"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="33"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="580" mass="65071" checksum="B950AAD3F2AD8659" modified="2012-07-11" version="1">MRFSQLYAPTLKEAPADADLISIKLLVRGGFVRKVAAGIYSFLPLGFRVLKKIEDIVRQEMNAIGSQEILMPIIQPAELWHETGRWDDYGPEMMRMQDRHERFFTLGPTHEEIITHLLRNELNSYKQLPVSLYQIAMKYRDEIRPRFGLMRSREFLMKDAYSFHGSWSSLDETYKQFYGAYSKILQRIGLEFLVVEADSGAIGGNESHEFNVLADYGESTLLYCDCGYAASDEKAEYLLQEESQEGAVADLKIVPTPNSRTVDEVSAFLEVTSRDIVKSLIYKGRKGYYMALIRGNEELNESKLKAALEDQTLVMATPQEVLDLLGVPIGFVGPIGLPKEVTIIADHTIKGLKNAVCGALKEGYHYSGVLPGRDFKIDSWHDLKMVTEGDPCPKCGAPMKSAKGIEVGHIFKLGTKYSEKMNGYVTDEKGNSIHYIMGCYGWGVSRTISAIVEQLHDENGIIWPLAVAPFDIIVTAVNIKDPIVSEKSIQLYDILSEAGFEVLLDDREISPGMKFKDADLIGIPVRITLGKKLAQGIVEVKPRTEKKPLEVSIVDGFDTLLEEIKKELSNYRPVSKMEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F203</accession>
    <name>I2F203_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0222"/>
    <dbReference type="EnsemblBacteria" id="AFK05956">
        <property type="protein sequence ID" value="AFK05956"/>
        <property type="gene ID" value="Theba_0222"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0222"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412070_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="82"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="376"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="666" mass="70228" checksum="B5E32D6B74B760B8" modified="2012-07-11" version="1" precursor="true">MPPETFTVTFNVSDSSGTLQGANVTFNGDSKATDAQGKAVFTGVLVGSRAYTVSKEGYNNSTGNVDVDGDESVDVTLTKKTYTLAVNIVGQGTVTKNPDKAAYTHGEVVQLTANPADNWNFTGWSGDLAGSTNPESITMNSDKTVTANFSIVQYTITASAGAGGTISPSGQVKVNHGSNQSFSISANTGYDIQDVKVDGATEGAIGSYTFSNVTSDHTIAATFKIKTYTVSVSSNPVEGGSVNGGGTYNHGAQVSCQATANEGYRFVNWTEGGVVVSDNSTYTFNITANRNLVANFVRVYSVTFSVVDSEGVLQGAEVSFNGETKVTDVQGKAVFTGVVTGSKAYTVSKEGYNSATGTVNIDSDKGVDITLVKKTYTLTVSSVGQGTVTKNPDKATYTHGEVVQLTANPDSGWNFDSWSGDLTGSTNPVNITMDGNKSITANFSEITYSITFSVSDSEGPVQGANVTFNSETKTTDNQGEALFTGITVGEKQYTVSKDGYGDISGSIVVDSSRTVNVVLEKKPMIEVVDSAFSVSEPLEILVRAQNLGEVDFIEIVLQFDTEYFGDSWDFRRKLPIDWQVIPSDPGNGIIHLALAITGGKTQVIDDLTSIVSIELTAKKIGTSHITFTSYTSVGNVPFETNIITAEGTRLSGSDLILDEGTITITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F240</accession>
    <name>I2F240_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730151.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0259"/>
    <dbReference type="EnsemblBacteria" id="AFK05993">
        <property type="protein sequence ID" value="AFK05993"/>
        <property type="gene ID" value="Theba_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0259"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063618_1_0_0"/>
    <dbReference type="OrthoDB" id="1427457at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="38721" checksum="E430196493A3C026" modified="2012-07-11" version="1">MARRSSGGSSSSNRSSGGRSGGSFSSSRSSRSSSSSSSSSRGSTSRPGSSFPSGIFGSSSRKKVGTSTFRIPVGGSRRPTAGGSGVNTAGCAGCGGCSLFVFGVIVIAILLIVLVASGTFSSCGSNPGNVEITKSTIAREPLPKGSVNETGYYMDELGWINKDSVLINGLKHFYQETGVQPYLYITDTVNGSHSPTADDLADFASGLYDKLFTDEAHCLIVFFEYGDGYMDRYVCGNQAKTVIDDEAADILLDYIDKYYYYDNFADEEFFAKAFSDAADRIMAVTRSPWIPVFIVIGIIAVIVLLLFWWSNVKRQENIEAKQTQEILNTPLEKFGDQEVEELTKKYEKKDEGNESKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F244</accession>
    <name>I2F244_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730155.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0264"/>
    <dbReference type="EnsemblBacteria" id="AFK05997">
        <property type="protein sequence ID" value="AFK05997"/>
        <property type="gene ID" value="Theba_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0264"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK05997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="286" mass="32455" checksum="ED28BB5D37DD5782" modified="2012-07-11" version="1">MITIQYYLNEGTILKKRYRIIEPLGRGGFGMTYLCSDFHTGNSVAVKEFFPRGAEREGNFVKPISSDLKEAYFERLSSFSEEFTIMSKIDDDRVVKVLDLFTENNTAYYVMEFISGRTLRDSVKSDGVVDESKALEIIDEILKGVSSIHERGYIHGDLKPTNVMLTDEGKIKVMDFGAACLKDVYLMNSLSKVVSLSYTCPEKFLSSSTPSYSWDVYSVGGILFFLLSGEDPIPSTERIKGIPLVLDLFPRKARRILEKSMSLVADKRYTDADHFRKALRPRLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F288</accession>
    <name>I2F288_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type transport system involved in Fe-S cluster assembly, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730184.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0311"/>
    <dbReference type="EnsemblBacteria" id="AFK06041">
        <property type="protein sequence ID" value="AFK06041"/>
        <property type="gene ID" value="Theba_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0311"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_2_0_0"/>
    <dbReference type="OrthoDB" id="422804at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="400" mass="45287" checksum="2488082FEE4DAD83" modified="2012-07-11" version="1">MEMTTELVHKNFEMVKPTRREELSIKDYDNRDFLISAEASSPAMLAFMSNRYSEYRTLAFPSWKRLKLTGMKLPEISPRRSLSYSDPFVRPLISMKSDEVELLDKLDFEGLDRKILLLGDIFFSEGSMISIPPNKSAEKSYSVAFNRDSRISSNMFVLGENSSLKVVIDSGRFGNWLLQNNRFLIKEGSSLELLVLNRVTERGHVFINNLYLLEKNAKLRVFEVNCGNASTAAFHLALLEGERALASFMPLFVARGDTVLDMQYVVRHRANWSEGRISGSGVLLDNSRSVFRGTIDIKRGAKGVKGSEYSNILMLSESARADTIPSLLVGENQVDAFHAATVGSIDAQKLFYLMSRGLTRDQSMSIIVQGKFEPTLREIDEIFPDHSGVVRDEFERDIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F296</accession>
    <name>I2F296_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730191.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0319"/>
    <dbReference type="EnsemblBacteria" id="AFK06049">
        <property type="protein sequence ID" value="AFK06049"/>
        <property type="gene ID" value="Theba_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0319"/>
    <dbReference type="eggNOG" id="ENOG502ZTU1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660239_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658477" evidence="1">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="44459" checksum="FF37215D50277852" modified="2012-07-11" version="1" precursor="true">MKKLVGILVVLLAISVAFSVTAVTLNPYLEGNLWGKVELDKTGLTTDLGFDVYSIGFGAAADVDGLTFSLAIDLVAPSVTLDSFTVENEKASASWYAAKSFGYDDGYGLSWFSYYGTTKGTTFVLNLKELGLQAATQEPDLLGASDRIALRGAWDIFSFSAQTGLKDLKWSGDVILEASLTPFKGLTVTGGVDASDLTGTPVFNYVVDVGYVLEVGLLTLNPYARYSDALGQWVGLNVGYGIGVLTIDANVQYDIAANALGAWIQPVISKDGIGYAGVKFVYNYDFVTPAQTMELGFLVKSLGWTAGPVSLDVFVGSGDFRTRDDVDLVGFGYEILTDVLADWTNISAYVKSALSLEMGSFKPTIGASGGYYIKDSASALNVNVSFPVLDLVTFSASVDILPAVDWSLGLYFDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B3</accession>
    <name>I2F2B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491911.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0337"/>
    <dbReference type="EnsemblBacteria" id="AFK06066">
        <property type="protein sequence ID" value="AFK06066"/>
        <property type="gene ID" value="Theba_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0337"/>
    <dbReference type="eggNOG" id="COG0851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187549_0_0_0"/>
    <dbReference type="OrthoDB" id="1879876at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="91" mass="10609" checksum="FF708D59C697F11F" modified="2012-07-11" version="1">MFFGLFRKKKKTEGSRKEAKDRLDSITGGRRYSVPVREVIPQDILQNSGKDMVHQIKTYVADKYKVKEENVKVQLEEHNGYVVIITNVVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B7</accession>
    <name>I2F2B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730209.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0341"/>
    <dbReference type="EnsemblBacteria" id="AFK06070">
        <property type="protein sequence ID" value="AFK06070"/>
        <property type="gene ID" value="Theba_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0341"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039510_0_1_0"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="355" mass="40453" checksum="B1EE468B4FE40234" modified="2012-07-11" version="1">MRQFSFGGLTLVGYYGYDNLGDDLLLLSSLSLIEEIEFEGPIYLPASPSINHIAHRFPSKLDVRIIKRFSIRELQTSIKNSILTVFGGGNLLQDQTSWRSFLYYYEIAKYTLKKDKPLLFLSQGFGPLSKTANRKALNKLLSDPLTYGVMRDAVSYKHFASISNKAILGTDYGPYYLRKKRIIPEKRETIAGLAVIVLKNGTSVDDVLHSLRLNNLSQVCAVGFHNHHDEQKRSELESKARSNGFKVRKPPENLEGMIEVFNNAELIITERLHGVILAISLGVPFVWKKNTKLDRFVRSLDKNCNLYFEESCESLSLSINSSLNKPVNLKEDYWSRLENTVNESKELLKKLLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E0</accession>
    <name>I2F2E0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uridine/cytidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730222.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0364"/>
    <dbReference type="EnsemblBacteria" id="AFK06093">
        <property type="protein sequence ID" value="AFK06093"/>
        <property type="gene ID" value="Theba_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0364"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_0"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="5">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="201" mass="23160" checksum="26D99731D5F336C7" modified="2012-07-11" version="1">MVLVSITGGSGAGKTSVTNMIFNHFMERAAVLSMDDYYKNLDPGTDPRQFNFDSPKAFDFELFEEHLRSVKENKSIMVPVYSMVTYRRESGICRKFIPKPLIIVEGLLVMFKKEMRDLFDFSIYIDAPADERLIRRIERDTKERGRSIESIIEQYRKFVAPSFESFIEPQKYFCDIVLPDGAANTTGLNVIINAIENMLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E4</accession>
    <name>I2F2E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="11" type="ORF">Theba_0368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730224.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0368"/>
    <dbReference type="EnsemblBacteria" id="AFK06097">
        <property type="protein sequence ID" value="AFK06097"/>
        <property type="gene ID" value="Theba_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0368"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_0"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="134"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="367"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="434" mass="48259" checksum="A358FEA70B293967" modified="2012-07-11" version="1" precursor="true">MKLGVLSLGCSKNIADMDNFMGIMANRGHEIVEDASVADLIIIDTCGFIDDAKKESVEEIFKFISLKQENPGLKVVAVGCLVQRYFDELKSEISEIDGLIGVTSPFTLADLIENGEFFYLKEPDGVYDFSSRVVSSKYSAYVKIGDGCNRNCAFCSIPNFKGKSVSRNPDSIVKETLSLIRKGVKEIDLVSQDCTQYGKDLNEKTDLKSLLERLNNIDGDFWIRVLYLHPDHVDNELVDSILSLSKVVDYFDIPVQSGSTRILKKMGRIKDSDRLRELLFGIRQKAPHAILRTTLLIGFPGESEATFNETLDFVRSVKFDRLGGFVYSNEEGTQAFGQKRTIGRKAAKEMLNSLLEEQDTISAGRLSQFKGQIMTVLVEESGSSYSLGRAYNSAPDVDGVVVLKGHNEDGVFVKARITDSYEHDMEGVILDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E9</accession>
    <name>I2F2E9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="8" type="ORF">Theba_0373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0373"/>
    <dbReference type="EnsemblBacteria" id="AFK06102">
        <property type="protein sequence ID" value="AFK06102"/>
        <property type="gene ID" value="Theba_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0373"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="327"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="511" mass="58170" checksum="FB01718F51F40C89" modified="2012-07-11" version="1" precursor="true">MMFLIGIIAGLAAGIALAYFIFTPSAVKKAKEELQLQLKSAKQDSESIIKRAQEEADHLKKKALIEGREELHRLREEQEKDFKRDREELKQWEDRISRREDNIDKKEEAIEKTRMQLDLERARVEEMKEEAEKKLFSLAELSMEEARNMVLKRAEEIYEHDLAQKLKELKDHYDEEGNRYAKWVIVNSVQRYAADYTGDVTVSAVSLPSDEMKGRIIGREGRNIRAFEKLTGSDLVIDDTPEVVVVSCFNPLRRAIAKMTLDRLVEDGRIHPARIEEMYEKSKKEIYNEIKEAGQEALMKVGIPSMHPELVKLLGRLKFRTSYGQNVLQHSIEVAHLAALMASELGLNVDKVKRGAILHDIGKAIDHEVEGSHAIIGGEIAKRYGEKSHVVNMIQYHHGETEALTPEAVLVAAADAVSASRPGARRESLDMYIKRLENLENIATGFKHIEKAYAIQAGREIRVIVEPEKVDDLLAEKMAIDIAKKIEEELEYPGVIKVTVIRERRSVSYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I4</accession>
    <name>I2F2I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730253.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0409"/>
    <dbReference type="EnsemblBacteria" id="AFK06137">
        <property type="protein sequence ID" value="AFK06137"/>
        <property type="gene ID" value="Theba_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0409"/>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_0"/>
    <dbReference type="OrthoDB" id="1835478at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="192" mass="22414" checksum="A0C917280C1FBB07" modified="2012-07-11" version="1">MNEVFRCPWAEVDKLYIEYHDTEWGVPLHDDNIWFEFLILEGAQAGLSWHTVLKKREEYRKAFSGFDPRVVSKYGENEITKLVENPGIIRNRKKIHSAINNAKRFIQIQEEYGTFDSYVWSFVNNKPIINTWKSLSEIPSVTEKSVEISRSLREKGFTFVGPKIVYALMEATGIVNDHLVGCFRYSEVLRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I8</accession>
    <name>I2F2I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730257.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0413"/>
    <dbReference type="EnsemblBacteria" id="AFK06141">
        <property type="protein sequence ID" value="AFK06141"/>
        <property type="gene ID" value="Theba_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0413"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_0"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="24991" checksum="708F56D269B49001" modified="2012-07-11" version="1">MILGICGNIGAGKSSLTSLLEETLGFRGVYEAVDENPFLEDFYSNMERWAFHSQLFFLIKRFDFLKRVVTEGAVILQDRTIYEDVEIFARNLKLMGYIDERDWRLYLDTYETLSEHLTAPDGIVYIKCTKNVLLKRIKKRGRGFESGVSEDYIERLNGLYEEWIGRVTFCRKLIIDGDKYDFVENAQDREDVLRLISRFTAELMAGVQSKLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K0</accession>
    <name>I2F2K0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hslU</name>
        <name evidence="8" type="ORF">Theba_0425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730268.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0425"/>
    <dbReference type="EnsemblBacteria" id="AFK06153">
        <property type="protein sequence ID" value="AFK06153"/>
        <property type="gene ID" value="Theba_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0425"/>
    <dbReference type="eggNOG" id="COG1220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033123_0_0_0"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="54"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="355"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="462" mass="52333" checksum="566B7744D77E2875" modified="2012-07-11" version="1">MNREELDELTPKRIVEELDKYIVGQDKAKRAVAVAMRNRIRRQKLPEEIRRDVIPKNILMMGPTGVGKTEIARRLAELTGSPFTKVEATRFTEVGYVGKNVESIIRELVDVGVNMVKQEKMGEVEGKASYQVEERILEALVPGPQTKAAGPRNIIELFQGQQQPKPSQEEAERIRNRREDYRDRLRSGDLEDLDIEVEVEDHSQQMIMIPGMEDMGIDMSGVLGGMVPKKTKRRKMRIADARKTLLPIEAEKLLDMDKVVAEAIERVQNRGMVFIDEIDKITFRSGSHGPDVSREGVQRDLLPIIEGTTVTTKYGQIRTDYILFVAAGAFHTAKPSDLIPEFQGRFPIRVELDALSQKEFLRILVEPKNAITKQYMALLETEGVKVTFTEDGLREIARVSHSLNEKIENIGARRLYTVVEKVLEEVSFNAPEVPQEIVVDVNYVNERIGEIAADEDLSAFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q3</accession>
    <name>I2F2Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492095.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0480"/>
    <dbReference type="EnsemblBacteria" id="AFK06206">
        <property type="protein sequence ID" value="AFK06206"/>
        <property type="gene ID" value="Theba_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0480"/>
    <dbReference type="eggNOG" id="COG2359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168904_1_0_0"/>
    <dbReference type="OrthoDB" id="1985350at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007347">
        <property type="entry name" value="SpoVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35331">
        <property type="entry name" value="PTHR35331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04232">
        <property type="entry name" value="SpoVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="91" mass="9727" checksum="8C8ADAEA068B195E" modified="2012-07-11" version="1">MEILKVSSKSNPNKVAGAIAGVISKNEQVELQAIGAGAVNQAVKAVAIASRFLREQGTKVYMVPGFVEIQIGEEMRTGITIKIVSEKDEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q5</accession>
    <name>I2F2Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730320.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0482"/>
    <dbReference type="EnsemblBacteria" id="AFK06208">
        <property type="protein sequence ID" value="AFK06208"/>
        <property type="gene ID" value="Theba_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0482"/>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_1_2_0"/>
    <dbReference type="OrthoDB" id="1115239at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="435" mass="45549" checksum="6FFB0E57D7F86358" modified="2012-07-11" version="1">MSSENSAYQEVREQEDRSKNLGRGGLLVLGLQHAFTMFGATVLVPYLTGVPVNVALFTAGIGTLLFHLLTKWKVPVFLGSSFAYIAPINAVILYHANAPEIYESVPEAIAAGFSITPDMIAYATGGILIAGLVQVAIAMLIKRLGVSMFEKIFPPAVAGTIIAVIGLNLAPTAISMASSNWWIAIVSLGTAVLVRLYAKGFTRLIPVMCGIVVGYVVAAITGNVTLDAVSQASWVGLPQFVLPKFSFYSLTVLVPVALAPTIEHFGDIFAVSAVVGKKYYEDPGIHRTLAGDGIATAVAGFFGGPANTTYSENTGVLAITKVFNPIVMRIAAVFAIILSFVPKVGALIQSIPTAVMGGIEILLFGMIAAIGMKTLIENRVKVDGKNLIIVSVMLVVGIGGAAIGIGPVRFEGIGLAALVGLLLNGIFVMTKAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X8</accession>
    <name>I2F2X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na+/H+ antiporter NhaD-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_0558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730378.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0558"/>
    <dbReference type="EnsemblBacteria" id="AFK06281">
        <property type="protein sequence ID" value="AFK06281"/>
        <property type="gene ID" value="Theba_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0558"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_0"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="14"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="424" mass="46112" checksum="4B7F5DF40291BCE7" modified="2012-07-11" version="1" precursor="true">MQWLFVLVVFISAYYLIISGKFNRSTVAFAAGILILLSKVIPDFDMKELGYLIDFNTISILIGMMIVVGTLRTTGFFEFVAVHVVRFSKGNVRALLIFFVVTIALFSAFLDNVTTILLFAPIIFLVADALEVSPRTFILAGVLAANIGGMATLIGDPPNILVGSASGFGFMDFMRIDGPITLFALIIALIYLDRRVFKDYREMGGKLQRIANMDPKKAIISKSALYKSLAVFFAIIVGFLLHGLIGVEPSLIALAGAAAAMILNGKSFSHLSEDIEWDTIFFFMGLFVLAFALKEVGITSVISDLLGSLSGNKIVLFLTLYWLSAIMSGFIGAVPAVTFMIPVIQEMTTKFGVPADIWWVISISACLGGSFSIAGSAANMVGVGLIEKHSKERLTYGDFLRFSMPITLITLVAGTLYILVRFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I4</accession>
    <name>I2F3I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730541.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0773"/>
    <dbReference type="EnsemblBacteria" id="AFK06487">
        <property type="protein sequence ID" value="AFK06487"/>
        <property type="gene ID" value="Theba_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0773"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_1_0_0"/>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="385" mass="43412" checksum="33D966B612B29F72" modified="2012-07-11" version="1">MAFVNGKKEGTARRLKKMKKVALIFGTRPEAVKMAPVYLALKNSPIRPVVIATAQHREMLDQVLSLFGIEADFDLNIMQERQSLAGLTSRLISKLEEIYSENVFDATLVQGDTTSTFAGALVSFYHKIPVGHVEAGLRTENIYDPFPEEINRRLNGVISSFHYPPTENAKNNLLKEGVPENKLLVTGNTVIDALLWVTENRSVLTSSFREALGVEEDEYILVTMHRRENWGEPMRQVMKAIKDILKEFPKMKVVFPVHLNPAVREVVYPELEKHDRIVLTDPLDYLPFVSLMEKARIILTDSGGIQEEAPALGKPTLVLRKTTERPEAIKAGTAKLVGTDRDFVFNETVKLLRDSDEYRRMANAKNPFGDGTASKRILKHLCENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L3</accession>
    <name>I2F3L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0802"/>
    <dbReference type="EnsemblBacteria" id="AFK06516">
        <property type="protein sequence ID" value="AFK06516"/>
        <property type="gene ID" value="Theba_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0802"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_0"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="529" mass="60259" checksum="30EBD59345BE86FB" modified="2012-07-11" version="1">MLLSLAGKDFLTFKDFYVEFSGGMNAITGESGAGKTVFLKALWAVLGFPPLWDNDGSGSVEGNFAVDGSLLSKLADMGVEINGDQLLVSVSFTGQRTIYRMNGKMVPKQIVQSAFRDRVEIHSQHSSISLLDESKHHIILDHALGGDTILTRYSELYAEYIKVRRELDSFIVDPSQIEREKDFLEFQIREIEQADLQPHEDEAIEMKYTRYRNAQMLLETFQELTDLLKDGELSIYNSLNDARATVEKIRNFGYKDWLDNLQIALEELDSLYTKIEEERSTLEIDDEEFNAIESRITIIQGLKRKYGDSVEKILVRLEEFKKELGTLKELEGRKERLKKNEEELLSSLKETGRILDQKRLVRAKEIEEQIRVHLEDLRMKGAELRFHLEPELMPRSYGTSKVTMVVKTNPGMDLMEIGSVASGGELSRFLLALESALKNQLDLKTIVFDEVDSGVGQRLGTVVSGKLEEISREIQTIVITHLPQIALSSDRHFVVRKQQVHNETISIIEELHGSSKEREIEEMSGQIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M2</accession>
    <name>I2F3M2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">Theba_0811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492509.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0811"/>
    <dbReference type="EnsemblBacteria" id="AFK06525">
        <property type="protein sequence ID" value="AFK06525"/>
        <property type="gene ID" value="Theba_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0811"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="339" mass="36104" checksum="4A91256E943F246E" modified="2012-07-11" version="1">MFLRQDMGIDLGTANTLVYVKGQGVVTNEPSVVAIDVNSGKILQVGLEAKRMVGKTPASIVATRPLKDGVIADYDIALAMLKYFMGRAIGRRTFVKPRIVIGVPSGATEVERKAIVDAAIEAGAKKVFLIEEPMASSIGAGLNVEEPTGNMIVDIGGGTTEIAVISLGSIVLSQSIRVGGDEMDDYIVQYIKEKYRLMIGEKTAERVKMEIGNVVETEEADGSYAEIVGLDLNSGLPRKISISGSEIREAIAEPVSRIVEAVKLTVENTPPELISDIVQSGIVIAGGGSLLNGMQELIQRETGIMVVIADDPLTCVARGAGQVLERVSILERIEKGNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N6</accession>
    <name>I2F3N6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">Theba_0825</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730583.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0825"/>
    <dbReference type="EnsemblBacteria" id="AFK06539">
        <property type="protein sequence ID" value="AFK06539"/>
        <property type="gene ID" value="Theba_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0825"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_0"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="124"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="243"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFK06539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="393" mass="43061" checksum="71602419C7291E80" modified="2012-07-11" version="1">MKTWLFTSESVTEGHPDKMADQISDAILDAMLTQDENSRVAVETLLATGVAVVAGEVSTKAYVDIPRVVRDTILDIGYNRAKFGFDGETCAVLTSIDEQSPDIALGVDRSYEAKKNDVDRYALIGAGDQGMMFGYATNETPEMMPLPIVLAHRLARRLSQVRRDGTVQGFRPDGKTQVTVKYQDGKPVGVTAIVVSTQHDPDLTSHEIERLVVDNVVAPVIEHDLLLEGVEIFVNPTGRFVKGGPSADTGLTGRKIIVDTYGGWIPHGGGAFSGKDPTKVDRSAHYMARYTAKNIVAAGLAERVTLQLAYAIGVAKPVSFMIDAHDTEKVDLEKLRKAVLKVFDFRPAAIIDRLNLRRPIYRQIAAFGHFGRIDVDLPWEETDAVDQLKKALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z9</accession>
    <name>I2F3Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730673.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0946"/>
    <dbReference type="EnsemblBacteria" id="AFK06652">
        <property type="protein sequence ID" value="AFK06652"/>
        <property type="gene ID" value="Theba_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0946"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="32859" checksum="F47229E507F4BD1F" modified="2012-07-11" version="1" precursor="true">MHSRFPNRFLPYLLLLPSVVVVIIFLIVPTIQSLYLSFFRVSPFGDRLIFVGWYNFSKLFKSSDYIDSLVITLVFAVFVVLIGLTLGMLLSVLLNQKLKGLQVYRTLFIWTYAISPAVAGTIWALMFSPSSGPITFLLKAIFGANVNWMMDGKVALVAVIIAASWKMLGYNIIFFLSGLQTIPQELMEASAIDGASSLRRFFKITIPLLSPTTFFLLIMNTLYAFFQVFGLIDIMTKGGPGDATQVLVYKLYRDGFINLDTGFASAQSIVLFIFVAILTVVQFRFAEQKVFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F412</accession>
    <name>I2F412_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730686.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0959"/>
    <dbReference type="EnsemblBacteria" id="AFK06665">
        <property type="protein sequence ID" value="AFK06665"/>
        <property type="gene ID" value="Theba_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0959"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_0"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="34664" checksum="998B86F4143624F1" modified="2012-07-11" version="1">MSFFELGSAKKADLKEYYDVTIIGGGPGGITAGIYAVQAGLKPIIVEKALDGGQMNNTQTVENWTGFTTISGMELSEKMADHARAFDVPFVYAEVVDIETNGLEKAVVLDNGKRIKSRVIIVATGSNPRKLGVKGEEEFKGRGISYCATCDGHFFSDKHIAVIGGGNSALDESLYLSKMVSKITVIQNLPKLTADRLLQTKLNDTGKVEYIYSSVVDSVEGDSQVRKVNIKDVNSGEITSLGVDGIFVFIGLIPNTQFLKGKLEMNEFGYIKADDFMETRTKGVYAIGDVREKEVRQIVTAAADGAIAIYHAARNYFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F461</accession>
    <name>I2F461_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">Theba_1009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730725.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1009"/>
    <dbReference type="EnsemblBacteria" id="AFK06714">
        <property type="protein sequence ID" value="AFK06714"/>
        <property type="gene ID" value="Theba_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1009"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_0"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="715" mass="74716" checksum="FCB6E761E19D953D" modified="2012-07-11" version="1" precursor="true">MNSLYLPLVAGIISTIFAFVMLRRTLGFSQGNDRMKELSKYVQEGASAFLEEEAKKIFLVAVILAAVLGIIFQSFKYPIVLLFGALVSEAAGVIGMYAATRANARVAAGAESGLSSAFKVAFSSGSVMGLAVAGFSLTGLAVVMLVFKSSFVFEGITDLSKAFGRISYIDGVMILSSYSLGASLIALFDRVGGGMYTKAADMSADLVGKIEEHIEEDDPRNPATIADNVGDNVGDVAGLGADILESYVASIVSAIVLAIFMKFADHGTMTESQYYGLILLPVLIAGAGVLSSLIGVLVVASLKSKDARKSLSFGNLFTGGLVLASVAIVIGIAAPDYPFKDAFLINPEFVSRWRLFFAIASGLIAGIIISKLSEYYTSDDYKPTRKLAKDTQSGVAINITGGLALGMGSTLWPVITLAIAILAAYLSAGVYGIAIAALGMLSFVGYIVSVDSYGPVADNAGGIAQMANLDPKVRKLTDRLDSVGNTTAAIGKGFAIGSAAFAALSLIVSYIWGSAGTAEEIINNPVINLVEPYTLIGILLGGMLPFFFTSLLIKGVADTANLMIVEIRRQFKETPGIRTGEAVPDYRRCIEITTKGAVSRMLTPGVVAIASPFIVGFLFGRSAVAGLLVGGLSSAIMIAIFSANSGGAWDNAKKFIETGEYGGKGTPTHEAAVVGDTVGDPLKDTVGPSMDILIKLMSVVSLVFGSLFPVTPFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F464</accession>
    <name>I2F464_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type uncharacterized transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730728.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1012"/>
    <dbReference type="EnsemblBacteria" id="AFK06717">
        <property type="protein sequence ID" value="AFK06717"/>
        <property type="gene ID" value="Theba_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1012"/>
    <dbReference type="eggNOG" id="COG1101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="239" mass="26414" checksum="0B213F4F54996FFF" modified="2012-07-11" version="1">MVEFKDLTVTYNPGMENERVALKNVSLTVLEGQFVTIVGPNGAGKSTLLKVILGEVQPTSGLYMIDGKTMNYMKPHKLAEFIGRVYQDPNTGIFPALTIAENLIIASKKGNRPFKFSSVKEEAISLLRDLGLGLEDRLKTKAGELSGGQKQSLAMVMAILSKPRLLLLDEHTASLDPDSASRVMELTERINREYDITIIMITHNMDIANSYGERLMRLMEGEVVNDGMRNIVPRVTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F484</accession>
    <name>I2F484_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1032"/>
    <dbReference type="EnsemblBacteria" id="AFK06737">
        <property type="protein sequence ID" value="AFK06737"/>
        <property type="gene ID" value="Theba_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1032"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
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    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="34929" checksum="FD6077758AC4BEC6" modified="2012-07-11" version="1">MAENYLVTGGAGFIGSHVVDHLISSGKIPVVVDNLSSGKIENLDPRALFYEQDITDQEMMERVFMLHRPTVLFHLAAQISVSRSVREPEEDAMVNIIGSLRLLKIAAKYGLKKVIFSSTGGAIYGDDVKRIPTDEEELPKPLSPYGIAKYATENYLRFFSSELGIKYTVLRYANVYGPRQDPYGEAGVVAIFSERMLHNQEVVIFGDGECVRDYVYVGDVARANLLAIEKCENTVINIGTGIGTSVNELFDIMKPIAGYSREAVHKEPRPGDVKKSILNIERARSLLGWEPSTQLERGIKETIEYFRSGLDSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B6</accession>
    <name>I2F4B6_9BACT</name>
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        <submittedName>
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    </gene>
    <organism evidence="6 7">
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK06769">
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        <property type="gene ID" value="Theba_1064"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="292"/>
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    </feature>
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        <location>
            <begin position="80"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK06769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="303" mass="34525" checksum="C847A3BAE55E2361" modified="2012-07-11" version="1" precursor="true">MEQIPVKPIKRKTTLKDVWKGRSGYLFILPHFALFAIFFLVPVGWGMYLSMFKYNVFSQTFVWFDNYKRILSDWLFLKSLKNTFIYTFGVVPLWLGKALLVTVLIYPFRKSIQTFFKAAFYLPHVTSTVIVSMIWLWVFNPNFGLLNYFMSLLGLEPVVWLGRSLTAMPSLIMMQVIMGGGSTIVLLSAAMASIPEYYFEAATLEGASSWAIFRKITLPLLKPTILYSLVMGTIANFQTFSNIYIMTSGGPEFSTTTVAYLIYETAFKNYNLGLASAMSMVMFAILVVLGIIQFKWLGSNVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B7</accession>
    <name>I2F4B7_9BACT</name>
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        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="276" mass="30728" checksum="0F7AB43F9D9C3239" modified="2012-07-11" version="1" precursor="true">MKAKTKTNIKKIISLVILAVLASLAFIPLYWMVATAFTQPSLTMKFPPDIIPKNPTLQNFKDLFERKIIFRWTLNSFIVAGTVTLAQIFVCAMAGYALAKKKFPGSKVIFSIYIASMMIPTQVTLVPLYILISKMGMVDTYQALILPAIAAPFGVFLMRQFMVSVPTEIIEAARIDGASEFKTFAKIIVPISKPAMAVLGIFTFMGQWNSFLWPLIVTNTSEMRTLQAGLSLLQEQVPMQYSYLMASATYSAIPMIIVFLAFQKYFLKGITVGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D1</accession>
    <name>I2F4D1_9BACT</name>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730782.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1079"/>
    <dbReference type="EnsemblBacteria" id="AFK06784">
        <property type="protein sequence ID" value="AFK06784"/>
        <property type="gene ID" value="Theba_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1079"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758174_0_0_0"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="364" mass="40911" checksum="0BE0F7EDDB468050" modified="2012-07-11" version="1">MTRHDTVKAYIDEASVEAVLFTRNSNIQWFFEGEVEPRIDTSTDMGAFWLLITSSMVIALCPNYDVHRIRDEILPKDVEVLGFDGFSNSVESAGRLCDKFSKVAVDSDLFFPSSSYVSIGRDFYEKTQLLSEREILRLRVTGKLTENIICEFAPELQPGMTELEVEKVLRAIFIESGLEVPTLCIASDERISKSPYPVSTVKKISRYLMLRATIRKQGLSVSLSRYFHFGAIPQEIEQRHERASGIAAKGAVAIMRARTMGEVYEEIKNAYASLNAANEIAYYSPGGTTGYTQNTFLFAPDSQITMKHPATYVLNPLIGGLLSEDTVLLNSDGNAEFLTLGEDFPKVKVRLESFRVHRPWIMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E4</accession>
    <name>I2F4E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730795.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1092"/>
    <dbReference type="EnsemblBacteria" id="AFK06797">
        <property type="protein sequence ID" value="AFK06797"/>
        <property type="gene ID" value="Theba_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1092"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="405"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="438"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="647" mass="73641" checksum="527BDAAAD5D5829A" modified="2012-07-11" version="1">MAENVYSEIEEKLKVEDWRVVFRLWKYTKPYVPILILALVLIAASTALDLLPPLLMRKAIDDYMDNQYSLVVVEEGDSYSFVQSEEGTFYLQQDESGMYSVTDGTTTYPITEKQLTELRVEDLNGIGQIAIFMSLILFSLFFVNYGQVYATSYMGQKITHGIRVDLFRHLIRVPMRFFDTNPSGRLATRVANDTENLAEFFTSVITSMVKDVLLLGGIIIIMLNLSTYLGLITVAILPVIAGAIFVFRYFDRVAYRKVRTRLAIINAFLAEHISGMSITQLFNQEERKKKEFDTVNKSHFKSLMEQLWVFAIFRPLLDLLYYVTIAIVIWFGVKSIIGNTLAFGVLVAFISYIDMFFRPLQDIAEKYDIVQNAMASAEKIFKLMDEEEEKYNSNESGVKSLEGTVEFENVTFAYDGEHKVLKDISFSVRPKEKIAFVGETGAGKTSIISILTGLYKIQSGKIKIDGRNIYDYNLQSFRKKVGVVLQDVFLFSGSILDNIRLFDKTISREKVIEAAKYVYAHHFIERLQDKYDTVILERGGTLSAGERQLIALARAVVFNADILVLDEATANVDTETEALIQRAMERISKEKTMITIAHRLSTIRNADRIMVIHKGMLVESGTHEELLSKGGIYSDLYRLQYELGDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F7</accession>
    <name>I2F4F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tetrahydrodipicolinate N-acetyltransferase</fullName>
            <shortName evidence="7">THP acetyltransferase</shortName>
            <shortName evidence="7">Tetrahydropicolinate acetylase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dapH</name>
        <name evidence="9" type="ORF">Theba_1105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:13085"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58117"/>
            <dbReference type="EC" id="2.3.1.89"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transferase hexapeptide repeat family. DapH subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.89" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730807.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1105"/>
    <dbReference type="EnsemblBacteria" id="AFK06810">
        <property type="protein sequence ID" value="AFK06810"/>
        <property type="gene ID" value="Theba_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1105"/>
    <dbReference type="eggNOG" id="COG2171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103751_0_0_0"/>
    <dbReference type="OrthoDB" id="752123at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047200">
        <property type="term" value="F:tetrahydrodipicolinate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01691">
        <property type="entry name" value="DapH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019873">
        <property type="entry name" value="DapH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013710">
        <property type="entry name" value="DapH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08503">
        <property type="entry name" value="DapH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03532">
        <property type="entry name" value="DapD_Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DapH_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="235" mass="24909" checksum="1CB485AAB33959D9" modified="2012-07-11" version="1">MDAEMIIRMIRDAKKKTPAVCYLSGDLRGLKHENVRFVGGKDFGILFGDLKEIEAILELHSERISAHYIEVKARNSALPLADLTKYHARIEPGAIIRDLVEIGDNAVIMMGAVLNVGAVIGEATMIDMNAVIGGRAIIGANCHIGAGAVVAGVVEPPSATPVVIEDNVLVGANAVILEGVRVGDHSVIAAGAVVTKDIPPYSVAVGMPAKVVKRFDEKTASKTSLVQELREIQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J0</accession>
    <name>I2F4J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06843">
        <property type="protein sequence ID" value="AFK06843"/>
        <property type="gene ID" value="Theba_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1141"/>
    <dbReference type="HOGENOM" id="CLU_3397370_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="31" mass="3922" checksum="7C661DCDE3284937" modified="2012-07-11" version="1">MHTFKDFFFQERERTGYKGDREGRERKKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L6</accession>
    <name>I2F4L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">Theba_1171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730858.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1171"/>
    <dbReference type="EnsemblBacteria" id="AFK06869">
        <property type="protein sequence ID" value="AFK06869"/>
        <property type="gene ID" value="Theba_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1171"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_0"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="27"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="36896" checksum="29AE2029A979E59C" modified="2012-07-11" version="1">MTEEEKGAYSSTHYSQLTTDSKIYVAGHNGLVGSAIMRKLESEGFRNIVTRTFEELDLTNQKATREFFEKERPEYVFLAAAKVGGIQANSVYPADFIYINLMIECNVIKASHEFGVKKLLFLGSSCIYPKLAPQPIKEEYLLSGYLEETNEPYALAKISGMKMCQYFNKQYGTNFISVMPTNLYGPNDNFDLNTSHVLPALIRKFHEAKVNKAPYVEIWGTGTPRREFLFVDDLADACLFLMKNYSGNDFFNVGTGEDVTIRELAELIGEVVGCKGELKFDTSKPDGTPRKLLDVTRIHEAGWRHRIGLKKGLEKTYEWFSKTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L9</accession>
    <name>I2F4L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730861.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1174"/>
    <dbReference type="EnsemblBacteria" id="AFK06872">
        <property type="protein sequence ID" value="AFK06872"/>
        <property type="gene ID" value="Theba_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1174"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_4_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="107"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="45537" checksum="0C699D679A5513B4" modified="2012-07-11" version="1">MSRETPSVLIFSEMFPKPKSSSSGVFIVERLKALTELGVPFDFAPVSTFDNFPIRLVKKLKGYSPSESVKSVNLNEKHYPVLNVSLGLRDRIGLIRQEANSWVKYARGMATAIEKNKKIQEFRLLHAHRVFPEGYAALLLSEKYNVPYIVTAHGGEIHSISNNNKAFVKEVLEKAAKVIFVSKALMRDASEKLDYDKSNGIVIPNGVDTNVFKPMDKEEARRKMSLPLDKKIVGFVGNLMEVKGADRLPAIAEELMKLRSDVFFLIVGDGPLINTLRECMPTDLTHFAGRVEYELMPVVMNGIDVLVIPSRQEGFGTVILEARACGARVVGTNVGGIPEAIGDERLLSSNSEDLSEELAQRISWIISDELEFDTVSHCVPSYDWHEIARKERDIYEEIIGETAKSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M0</accession>
    <name>I2F4M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730862.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1175"/>
    <dbReference type="EnsemblBacteria" id="AFK06873">
        <property type="protein sequence ID" value="AFK06873"/>
        <property type="gene ID" value="Theba_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1175"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721217_0_0_0"/>
    <dbReference type="OrthoDB" id="1643411at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="140"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="383" mass="44929" checksum="564F45D06C61BFE2" modified="2012-07-11" version="1">MLTRLKRYFSIRILGNPDIRNPREDDVELYKPCDVIVDWPREKKKPFVGLTRDTNENPHWTKYRRFLKNNGFDFEIFEYHRSDWLEAAKNFDLIIWSPNSGPAELDEIKRKIYILEKKLGKKCFPDYETLLLCDDKVMSTYFLKMNGLPVADTFISNDYHEIEQMKTKFLFPLVSKRFHGASSREVDLIKNPAQLSRFSRRAFSFYGKKCSNAYFRQKNYVYLQRLVNGDGLDVRVNVAGNVVTGYFRKPKRNDFRASGSGIVIKEDLPLEAVEIALKTYGLIGKAMLGVDMMRDREGKFWIIEISPFIGVITPIQMKVDNVPGCYFLLEDGTLEFKKDNYWPQELAMKNFLERNYLLPEAEWKSNFVLSVVSEKKLKRNFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N2</accession>
    <name>I2F4N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative periplasmic or secreted lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730873.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1187"/>
    <dbReference type="EnsemblBacteria" id="AFK06885">
        <property type="protein sequence ID" value="AFK06885"/>
        <property type="gene ID" value="Theba_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1187"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_6_2_0"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="80" mass="9307" checksum="DE46238C8E56B32C" modified="2012-07-11" version="1">MKLPRDITFEELLKVLTKLEYEVTRQTGSHVRLTTKRKGEHHITIPHHSTLKPGTLNAILIEIAGHFEMTKKDLLEFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q2</accession>
    <name>I2F4Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1208"/>
    <dbReference type="EnsemblBacteria" id="AFK06905">
        <property type="protein sequence ID" value="AFK06905"/>
        <property type="gene ID" value="Theba_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1208"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="189" mass="21860" checksum="136EDC3624ABD1CA" modified="2012-07-11" version="1" precursor="true">MRAKLSSRERIIRAARKAFAERGHDGVSMSEIAQMAGVKKALIYYYFPSKEDLFYEVWQYSIDELEDHVFSETSDENVYVSKLKRILRSYIDFITSKNEIKKIMDQERANLSREDNESWKRVRDRYEALKEKLSSAINDAKAAQEISKDVDPDSAADLILNGFSITEDPDGLESIREIIWRGLFSNSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T1</accession>
    <name>I2F4T1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ORF">Theba_1246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730915.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1246"/>
    <dbReference type="EnsemblBacteria" id="AFK06934">
        <property type="protein sequence ID" value="AFK06934"/>
        <property type="gene ID" value="Theba_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1246"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_0"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="416"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="631" mass="70721" checksum="0DEE0948696AFD48" modified="2012-07-11" version="1" precursor="true">MSDLYNAQNIKILKGLDPVRKRPGMYIGSTGKSGLHHLVYEIVDNSIDEAMGGFCDRINIVITEDGSVIVSDNGRGIPIDIHPDTGTSALEVVMTTLHAGGKFSKDSYKISGGLHGVGASVVNALSEWMIVEVMVDGKIYRQKYERGKALAPVEVVGETNETGTVTSFKPDPLVFTVTDFDFDILEARFKELAYLNGGIKITFEDRRIGEKRSYHFEGGIVEFVKALTKNKKSIHKDPIYLEGTYNDVKIQLAMQYTSSYDEDILTFVNNIKTIEGGTHLTGFKTVLTKTMNDVGRKHNVLKDKDPNLQGEDLREGLSAILSVFVKEPQFEGQTKAKLGNDEAFEAVMKVVKEKLEEYFDYNQKDLKAILSKALEASRARLAAKKAREMVRRKNALENTTLPGKLADCISENLDETEIFIVEGDSAGGSAKMARSRETQAILPLRGKILNVEKAGLDRMLKSETISNIIVALGTGMGEDFEIKNLRYGKIIIMTDADVDGAHITTLLLTLFYRYMTPLITNGKVYVAQAPLYKIELNRQKHYFYSDEELTTFLKEHSDRKLNYSRFKGLGEMNPEQLWETTMNPNDRKLVKITIEDAEEADRVFTILMGSEVEERRSFIQRHALSISNLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T4</accession>
    <name>I2F4T4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">Theba_1249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1249"/>
    <dbReference type="EnsemblBacteria" id="AFK06937">
        <property type="protein sequence ID" value="AFK06937"/>
        <property type="gene ID" value="Theba_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1249"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="213"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="349" mass="37067" checksum="94683D05D90831F6" modified="2012-07-11" version="1">MMSFEIDTGKKNTQIRLPSIKVIGVGGAGGNAVNRMISEGIHGVTFIAANTDVQVLESNKADLKIQLGTELTRGLGAGGNPNVGERAAEESVDEIGTFLEDTDLLFITAGMGGGTGTGAAPIVASIAREMGILTVAVVTTPFFFEGNTRLKTAHEGLRRLKNSVDTLIRISNNKLLQELPPNTSIVDAFAKADETLHHGIKGISELITKRGYINLDFADVESVLRNAGTAMLGIGVGSGERRAEEAARRALESRLLEKPIDNATGIILNVSAKNITLREMNIAAAIVRQNCSEDADVKLGLIVDPDMNDDELDITLIAAGLELDEGELMGDASDIPAIYRFGLDLSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U7</accession>
    <name>I2F4U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">Theba_1262</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730931.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1262"/>
    <dbReference type="EnsemblBacteria" id="AFK06950">
        <property type="protein sequence ID" value="AFK06950"/>
        <property type="gene ID" value="Theba_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1262"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_0"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="397"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="695"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFK06950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="789" mass="87226" checksum="FDC3E18C20DB159C" modified="2012-07-11" version="1">MKLYLEWINEFVDISDKSPQELSNSLSLSGTEVAGIEYPWSYVQGAVVGKIKSARPHPMSDRLLVTRVDAGVRELTIVTADLTVKEGETVGVLPEGSALSGTKIENKEFLGVLSEGMFLSLEELELEEKSQTIMRLEQGKPGESVIELLGLDSAAIEVELTANRGDCLSVVGMARELGAIYERKVERPCADDSIPVGDDGLLKVTLKDEGCTRYTALLMSDVTICGSPLWMKRRLVAAGLRPINNVVDITNYMMLETGHPIHAFDVDRIGSTEIVVRSARNGEKLELLDGKVVQLDSNDMLITNGETPLALAGVMGGEDSGIYSSTRKVLLEVAVFDPVRIRKTSRKLGISTDSSYRFERGIDYEDSIYVIRRLADLMERLSGASVASKIVDAGGTAPVKAIDLREEFVADRLGGVVPSEKIGAILESLGFKTERTDFGWKVTPPAFRSYDTRQEIDLVEEIGRIYGYDKIENVLPRVLPISGGVPEFLKRQKRVKDLMVANGFDEIVTYSFINPDEFDKLGTDPKHVALLNPLSMDMAVMRPSLVYNLLSAASYNYRRQNRDIKLFEIASVFNPEREQSETTALGFVATGRENPLDYSDKRILDFFTFKGVIDELCSLYGLDPVYNPLTISWLEKGKAVSVDVDGRKIGFFGAVDISAADALYEIKSGEVYVAELNISTIESLMKGFSGAKKISPFPRVFRDLSFLVPGSIAYGELEELIRRTLDGTSFEEIRVSDLYRGKGIEPGYKSITVTLGFESFDKTLTDDEINTLIELVLRKTEKIGVKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F566</accession>
    <name>I2F566_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731015.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1381"/>
    <dbReference type="EnsemblBacteria" id="AFK07069">
        <property type="protein sequence ID" value="AFK07069"/>
        <property type="gene ID" value="Theba_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1381"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_0_1_0"/>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="179" mass="19023" checksum="438501721E151B5B" modified="2012-07-11" version="1">MSEHLLIAAGFGGQGVMLIGQILATAGMFDNKHTTWLPSYGPEMRGGTANCTVVVSDEPIASPITNTPNELIIMNIPSLIKFEKEIQSDGLMVINTSVVDRDTIRDDISIIKVDANAIAEKLGNLKVANMVVLGAYLQKTGAVTLEGVKKALEEKLTGSKAALVNLNIKAIEEGMKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F582</accession>
    <name>I2F582_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731030.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1397"/>
    <dbReference type="EnsemblBacteria" id="AFK07085">
        <property type="protein sequence ID" value="AFK07085"/>
        <property type="gene ID" value="Theba_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1397"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756061_0_0_0"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="271"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="366" mass="43118" checksum="A03B610D4998961A" modified="2012-07-11" version="1">MLLERIKYIDWPAYDFLLCLMRVNCNEMIIEAYKEQDFKDQFVPDPELLEWAKETKKILPDDIKELLERFFDCETYFGAGTFSLVQERNLREPEEFIKALKSTSEKSILGRFLRTGFGTDVKSRDSSQFEELVERLTVDEKEMLLFITESTIFSSFQKANLLGFLENPAETKQDLIYLFEWFLENVFNRMRDEVRRSNEKHLKNLEEYIRKGGTSYIEKLNLLSFFDILETVQTIELSVSPFLGLDQAGLMVMKDRYLFILGYDRIEVPFREKDEKLQCIDVFSALAHKERLAILRELSREPHRPVSLAKKLRISAGDLSNHLEKLKKGRLLESVYDGEYVEYTVNAKELKRLVSESLDKLLEEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F597</accession>
    <name>I2F597_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731045.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1412"/>
    <dbReference type="EnsemblBacteria" id="AFK07100">
        <property type="protein sequence ID" value="AFK07100"/>
        <property type="gene ID" value="Theba_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1412"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_2_0"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="131"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="324" mass="36106" checksum="0900AACF1749EB6D" modified="2012-07-11" version="1">MTKIAILGIAHMHGYSYVRALKRMNDIEIAGLYDEDRSRMNKACKHLGIKPCEKPEELVARSDGVIVTSENSTHREFVEIAAGAGKHILCEKPIATTVEDAEAMIEICRENNVKLQIAFPVRYSASVRKAREIIAGGLLGEVVSLVGTNHGRMPGGWFIDPVLGGGGAVMDHTVHVVDIVRWLLDCEFTQVYATYGTLIHDIPVEDCGLEMFRLSTGQYMTLDCSWSRPKTHPYWGDVTLHIVGTEGTLFLDVFNSKIEVYSNEKGSRWEAYGDNFDCLLIEDFVEVLRSGKDPFTRGEDGLEALKVVDAAYKSFREGQEIQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B3</accession>
    <name>I2F5B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731061.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1430"/>
    <dbReference type="EnsemblBacteria" id="AFK07116">
        <property type="protein sequence ID" value="AFK07116"/>
        <property type="gene ID" value="Theba_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1430"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_0"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="33585" checksum="E27676FAEEE4BEF7" modified="2012-07-11" version="1" precursor="true">MRKNFWKFFIMMIPAFILLIVFTYTPIIRGGVMAFQRYNMFDLSDTGFIGFGNFKAIITDRNFDFVRILINTLVWVFFSLIFQFGLGFGLALLMRKPFKGRGIYSSLVFYPWAVSGFAIGLIWAWMFNGQFGIINDILVRVGIISNPIGFLSDPKFAMMSVIIANVWYGIPYFAIMLLAALQSVPNELYEASRIDGANRFKQLFKITIPYIRPTIVSTVLLRTMWIMNFPEIIYGMTGGGPANSTQILATHMINRIYQFYDYGQGAAIGFIIMSMLLLYAIVFLNISSRKEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B5</accession>
    <name>I2F5B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-lyase/cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731062.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1432"/>
    <dbReference type="EnsemblBacteria" id="AFK07118">
        <property type="protein sequence ID" value="AFK07118"/>
        <property type="gene ID" value="Theba_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1432"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_0"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="384" mass="43014" checksum="8353D0169EC4BD9C" modified="2012-07-11" version="1">MEKKYITEILHHLGEDDLPCGAVNPPIFQTSIFSFKGFDEFSTALSDETNHFLYTRGNNPTVNILEEKLAALEHAERAKLFGSGVAAIVSSISAFLKSGDHIVTVKDCYSWTSTYVTQYLARFGVEHTYVEGNDVNEIEAALKPNTKIIYLESPTTFTFKLQDLTEVSSLAKMRGVKTIIDNTWATPIYQNPIDFGIDLVVHSASKYLGGNSDVVGGVVAGSDEDVRRIFEKEFLNTGAVPDPFAAWLILRGIRTLHIRMPVHFQNAMELSRRLQKSEAVESVLYPMLESSEQYALAKKQMRGGSGLFSFKLKTRDIDRIKKFVNSLRFFRRAVSWGGYESLISPYAVSHRDPGDNVSLIRIHAGLEEIEVLSEDLDRAMKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C3</accession>
    <name>I2F5C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731070.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1440"/>
    <dbReference type="EnsemblBacteria" id="AFK07126">
        <property type="protein sequence ID" value="AFK07126"/>
        <property type="gene ID" value="Theba_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1440"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031277_0_0_0"/>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="47624" checksum="78E1AF7E4E941450" modified="2012-07-11" version="1">MSDFRPFRAVRPAEGIEQKVNCPPYDVVSFEEAREIGRNPESFMHVIRAEIDLPVDSDHYSDLVYEKARENFETMLQSGVLVQEEEPLYYIYWQKMKDHIQIGVVGGASVDEYQKDLIKKHELTRQDKEEDRIKHIKTVNANTGMVFLTFRSNEKLETLLQSYSRKLPLSMRVIDENDVEHRLYAVKERDGVEEIREAFKEIDCMYIADGHHRAASSSRVRELLKESNPGHTGNEEYNFFMAVAFPHTHLKIMAYNRVVQDLNGMSENEFLEKVGRVFEVEDAPKDPYEPAMRHEFGMCLMGRWYKLTAKKGTFDENDPVSSLDVDILQKNLLSPVLGIDNPRKDSRIDFVGGIRGLKALENRITNGWAVAFSMFPTSMEELLAVADEGKIMPPKSTWFEPKLRSGLVVHLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I4</accession>
    <name>I2F5I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487075.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07187">
        <property type="protein sequence ID" value="AFK07187"/>
        <property type="gene ID" value="Theba_1505"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1505"/>
    <dbReference type="HOGENOM" id="CLU_2538645_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="83" mass="10173" checksum="0BEEF8C9F9241927" modified="2012-07-11" version="1">MIFGYRSARETEEIFDIRFDERNSKRVFAEIYKGCYLLIRGEVRVRKSVYIRLRDFTVTTRPHDRDLDIDIPRILIHLRSDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M1</accession>
    <name>I2F5M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731134.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1550"/>
    <dbReference type="EnsemblBacteria" id="AFK07224">
        <property type="protein sequence ID" value="AFK07224"/>
        <property type="gene ID" value="Theba_1550"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1550"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055069_0_0_0"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="158"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="38131" checksum="57C7EAF4DA9B1CE4" modified="2012-07-11" version="1" precursor="true">MRVLLYSEGKKLFSKSGVGIALKHQMSALEKVGVEYTTNEEDRFDVVHINTVGPGAERILKKAKKSNIPVIYHTHTTYEDFRNSFTLSNAIAPWLKKRLIKLYSSADFLISPTEYAKNLIKSYGIDLPIKAVSNGVDNTRFSKNKVLAEKFLLENNIRKPLIVSVGLPFERKGVIDFCEIAEKRTDLVFYWFGAKISSLLPSKIRRLLKNPPDNVKFPGFIPQEMIIGPYSACDVFLFPSYEETEGIVVLEALATEAPIVLRDIPVYSDWMKHEENCLKAKNNKEFMENIDRLLHNESLRKKLSACGKGTALEKDLSIIGQELKKIYLEVLDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M4</accession>
    <name>I2F5M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07227">
        <property type="protein sequence ID" value="AFK07227"/>
        <property type="gene ID" value="Theba_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1554"/>
    <dbReference type="HOGENOM" id="CLU_1813532_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="142" mass="16139" checksum="A396D24A5F16A4DA" modified="2012-07-11" version="1" precursor="true">MIFSFVFLSILTFGLTGGVITRVEDPGCYLYECNCFLYSEFSYSKELIINTRFVPYAVYCCISTEARHYDANNNPLSVFASACGECRYSIDASPWSWEYVDVDCEGFGVASCNKCTIMFYFFQIEDDFEAEAVSESCFCSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T1</accession>
    <name>I2F5T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CRISPR-associated helicase Cas3/CRISPR-associated endonuclease Cas3-HD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_1620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731183.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1620"/>
    <dbReference type="EnsemblBacteria" id="AFK07284">
        <property type="protein sequence ID" value="AFK07284"/>
        <property type="gene ID" value="Theba_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1620"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009347_1_1_0"/>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="210"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="684" mass="77430" checksum="43D5439A4CDEEB9B" modified="2012-07-11" version="1">MSLAKPGVSLVEHTERVLDYAHSYLDQNKIALKNTNLDPKQISEAILTACAFHDIGKGCVEFSFDKKGFSHSLASAQIAMASLKESPIKNYILQSILGHHGSRFKDSFSSLEFQRQQATPNLELVNEFKEIKDYAKGHFRIELPDLDLQIPSPRELLKRLCNFFFGAPRDRRLYFLIQGILNLADWSASAKKSLSSASIKLDSRPLRTFQAEASTGKDTIILAPTGRGKSLAALVWTKSTGREKSTLFLPTVTTVEAMYKRYTEEVSDKTGLVHGNIAYYLYSNEGYSEDTRDRIFWMKAFDNPINVATLDQLLLMSLNWGRWEPKIVNIVNSAVIFDEIHASQPYTFGILLESIKMLNAMGTPVCVMSATLPSYMIQKLKEVLDYPVIVRDYEGESLRRITISHLEDVDPVEETKRQHKKGKKAILCFNTVKKATEAFKTLSDKIPDKEIILYHGRFNLEDRERILSRITGDSPPRIIVATQTIEISLDISYDVLITEAAPIDSLTQRFGRVNREGTTPIGEVMIFPQNENSYSVYNKNLVAKSLGLLKAHQTPSGLELREMMEDLLSEIENIEEEISAGKASWQFVREMNFQIYSMSIDQRLADDLIRRIPYKTIEVIPAEFRNDNSGKMQKLGKLVKVPVRDVIGRLEKDDDGFIYAPIIYDPSFGYLGPKEDEGSIVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5V1</accession>
    <name>I2F5V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1641</name>
        <name evidence="7" type="ORF">Theba_1718</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
            <strain evidence="6">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731201.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1641"/>
    <dbReference type="EnsemblBacteria" id="AFK07304">
        <property type="protein sequence ID" value="AFK07304"/>
        <property type="gene ID" value="Theba_1641"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07375">
        <property type="protein sequence ID" value="AFK07375"/>
        <property type="gene ID" value="Theba_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1641"/>
    <dbReference type="KEGG" id="mpg:Theba_1718"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="34930" checksum="8757ED1270536A28" modified="2012-07-11" version="1">MSLSVDGLRVYYQTLKGDIKALDGVSFDLRDGEIAGIAGESGCGKSTLSNSLIMLRLPMKLVEGSASLDGSPLPIGDQRKMNDFRYKRISIIPQYAMNALNPTVKLKRLISDLLACHGVGYEKTLPELNRRLDLVGLDSSVLKMYPVELSGGMKQRAVMVISTLLNPSLLIADEVTSALDVSTQRAVAEMIVEFRDKGFVKSIIFVTHDISILYQIADSILIMYAGKLVERAATEVIIKRPVHPYTKMLISSLPEVGVHYTDKRLKGIPGKPPQLLSPPRGCRFKDRCPIAFEKCEEEPPMVEIEPSHWVACWGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5W6</accession>
    <name>I2F5W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of uncharacterized ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1656</name>
        <name evidence="6" type="ORF">Theba_1733</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MesG1.Ag.4.2</strain>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1656"/>
    <dbReference type="EnsemblBacteria" id="AFK07319">
        <property type="protein sequence ID" value="AFK07319"/>
        <property type="gene ID" value="Theba_1656"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07390">
        <property type="protein sequence ID" value="AFK07390"/>
        <property type="gene ID" value="Theba_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1656"/>
    <dbReference type="KEGG" id="mpg:Theba_1733"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="271"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="527" mass="57592" checksum="D7623507BB1F4D7A" modified="2012-07-11" version="1" precursor="true">MFFGAPPGAPSSISRGVLPILVCNKVSKTYPNGLEALKEVSFDVKRGEIHAIVGENGAGKSTLMNILFGMFKPTSGEITFKDKQFSPKHPSEAIGLGIGMVHQHFKLVQSITVAENVVLGMEKRFQNRIGKINNAEMNSSVSSLIERLRMSISPDDRIQDLPISKKQQVEILKVLYRDTDFVILDEPTAVLAPNEVDDFLEFVTGIRDMGKTVVFISHRLGEVFAIADRITILRRGKVVGTFDKKDVNRESVANMMIGTASDLYERPENFVRDEIVLSVKQISDASGILKNLSFDLHEGEVLGFAGVGGNGQEELFEVLAGNLMLSSGEILLKGSSIESLNTLERRKAGLAYITDDRMKKGLAPDRSIVENSIAGHHKSGRFGKLAINSSKANAFTESIIADYDVRTGKNIRTPVRALSGGNMQKLLVGREIAYDPAVLIASQPTAGVDVAARKLIHDSFRRLSKSGSGIILISGDLEEIMDLANRIIVLYRGRAVAELAYPHYDTTEISYYMTGIRGSQNASCTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X7</accession>
    <name>I2F5X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731225.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1668"/>
    <dbReference type="EnsemblBacteria" id="AFK07330">
        <property type="protein sequence ID" value="AFK07330"/>
        <property type="gene ID" value="Theba_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1668"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_4_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="184"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="311" mass="34688" checksum="397A27F52A9A03A7" modified="2012-07-11" version="1">MNELREAILSNKDDFFSALENLSGAILILFDNEGKILDHSPSLISLVEKSDTLKGENICNLVVDNSQALLKRFGAKPVRIGLSDSRSNIHLVSGFVMLVDESRRLFLGVKIGLSAGDIMESMSKVTDELASLTRELARKNKELQAANKEIERLMNCDPLTGLSNRREFMNRLDKEIESLCSTCKPLSIIMADIDDFKRVNDTRGHPEGDRVLQLFADVLNEIISPRRTTVRYGGEEFIVMLPETTSEEATEIAEEVRKNFERETEKKLGLTVTASFGVATFKPSDTKSSILKRVDDALYSAKSGGKNRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F602</accession>
    <name>I2F602_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1695</name>
        <name evidence="9" type="ORF">Theba_1762</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MesG1.Ag.4.2</strain>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731249.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1695"/>
    <dbReference type="EnsemblBacteria" id="AFK07355">
        <property type="protein sequence ID" value="AFK07355"/>
        <property type="gene ID" value="Theba_1695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07418">
        <property type="protein sequence ID" value="AFK07418"/>
        <property type="gene ID" value="Theba_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1695"/>
    <dbReference type="KEGG" id="mpg:Theba_1762"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_3_3_0"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="243" mass="27247" checksum="D961078A53C70537" modified="2012-07-11" version="1">MSGVAYWTILMKDMKNYYLKPPNISWGIVFPISWTLMFFVRSGSDVEIRDILPGVMALSVLFGTTSMLAVTITFERKSRSFERLLLAPISLKLLMLAKTTGAILFGIINAFVPVLFALLIVDLSGINWFLVSVSVLLIAVTSTFLGLFIAVSASEVFEAQTFSNFFRFPMMFLCGLFIPIENLPAFLRPFSFVLPLTYGADSLKHAINRNGIIDPLASVFILLGFAALLFLISTRNIERRWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F620</accession>
    <name>I2F620_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1639</name>
        <name evidence="7" type="ORF">Theba_1716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MesG1.Ag.4.2</strain>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731199.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1639"/>
    <dbReference type="EnsemblBacteria" id="AFK07302">
        <property type="protein sequence ID" value="AFK07302"/>
        <property type="gene ID" value="Theba_1639"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07373">
        <property type="protein sequence ID" value="AFK07373"/>
        <property type="gene ID" value="Theba_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1639"/>
    <dbReference type="KEGG" id="mpg:Theba_1716"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="464" mass="52902" checksum="F3E57B5553C7F679" modified="2012-07-11" version="1">MLPYKGDEDMFGEDFLFGASLSGFQFEMGRNSPESIDRGSDWYAWAHDKLNIENGIVSGTFPESGPNYWTGFEEFHRLAADAGMKIIRIGLEWSRILPKPTFERWTDDLDDICNTEALEHYRGIIEDIRNRGMKVMVNLNHFSLPIWLHEPIRVNRYSDFTAGGWADPRAAEEFRKFAALCGRRLGDIVDMWSTENEPNVLATLGYRNRASGFPPSIIRPELAGVARDNLINAHLLGYEELKKETSSPVGLIYAMSWIDGEERAVDSALKAQFEFIDRIKDRTDFLGLNYYSRMVVESDEESDIGYKLLPGFGQGCKPNSLSRSGRPTSDFGWEIYPEGLYNILKTTMRRYDVPVFVTENGIADATDGLRPYYLIGHLKAVEKLIEEGFSVKGYMHWSLTDNYEWASGLGMRFGLVSVDFNDGSLTPRPSYYLLKEIIKQGSVNGFKKMLKEPYDIFDETLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F679</accession>
    <name>I2F679_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731266.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07432">
        <property type="protein sequence ID" value="AFK07432"/>
        <property type="gene ID" value="Theba_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1781"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48636" checksum="A34A6AEEB0E83D3D" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWRYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLKLHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTFRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSQLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F685</accession>
    <name>I2F685_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transaldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489191.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1787"/>
    <dbReference type="EnsemblBacteria" id="AFK07438">
        <property type="protein sequence ID" value="AFK07438"/>
        <property type="gene ID" value="Theba_1787"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1787"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_2_0_0"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="215" mass="24124" checksum="AEE4841E19E31BEF" modified="2012-07-11" version="1">MLYIDGICEKSVELVEQPVFAGITTNPTILKRDRPGWGLMDAMKFLSKVPGERHFVQGSLSSTEWIQKVKEFIKKSDFDPEFFTIKLPWDPQKASNIVPQLNDIGVGVCATAVYTLQQYYAAVSMEVEYVAVYFDRMVKAGIDADLRITEMLDIGDWHSNAPRIIAASIKDIESANKLISLGVHDLTLPIEIAAEYVQGSFPADDLNRFEADFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C0</accession>
    <name>I2F6C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_1822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731298.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1822"/>
    <dbReference type="EnsemblBacteria" id="AFK07473">
        <property type="protein sequence ID" value="AFK07473"/>
        <property type="gene ID" value="Theba_1822"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1822"/>
    <dbReference type="eggNOG" id="COG3548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090238_3_2_0"/>
    <dbReference type="OrthoDB" id="1399320at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK07473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="203" mass="23767" checksum="FD7F26EE6A8529A4" modified="2012-07-11" version="1">MKRESPGSEIRINRLEALTDGVFAIAMTILVLSLEVPSRSQVTSQSELVQNIMSKGYQFLSYFISFFVIGSIWISTIRRTHILNKTDYKHLWLNMLNLFFVTTIPFTTSLLGDYGEYEFAEVLFHLDILILETIALVQWQYLMNNKDLIREDAIDDSNLIYYRKVYIFHVIVPLLGIAVSVFTPVWSNLVYLVIFFRVFFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D0</accession>
    <name>I2F6D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731305.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1832"/>
    <dbReference type="EnsemblBacteria" id="AFK07483">
        <property type="protein sequence ID" value="AFK07483"/>
        <property type="gene ID" value="Theba_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1832"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_0_0_0"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="255" mass="27990" checksum="07A92CB8C782AA4F" modified="2012-07-11" version="1">MKVHIIGAGSIGGSIALRLSKRGHRVSIFDQNVVTTEMLRKKDPSIEVSSDAFTPGDLTVIALPMNSEEELLLSADFTGPAFDVASVMQPFQEIARLRKIRLISGHPMAGNVHKGPAGWDESMFDGRVFLFSPGEFATGEDLGLVLMVVSELGSSPEYLPPERHDYIVGRISQTAYFLSRTLLRLGGDFEKYSGPGYASTSRLGRQNMDMVLDMARFNGRNIASSLEEAESYLHDIRTAIEEGDLSKLEELISGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E1</accession>
    <name>I2F6E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731312.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1843"/>
    <dbReference type="EnsemblBacteria" id="AFK07494">
        <property type="protein sequence ID" value="AFK07494"/>
        <property type="gene ID" value="Theba_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1843"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078489_0_0_0"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="308" mass="36186" checksum="7FF97BA412B0DE69" modified="2012-07-11" version="1">MKIQTVGRRGVLFTFQDGDSVMGGETSVYLIEGGDRFYLCDTFLGSSFMNVVKDRIKESPRKDLVIFNSHSDFDHVWGNGAFGGCEIVAHELARRRMEERWEYDFENLERFRDGDVLKRLPNVTFSYRLVFEDDEIEFRYLPGHTLCSSVCIDRRDSVIFVGDLVEDPLPLTLWSDLVTFTESLKTVLKMSCQTVISGHSGIVAESLIRRNLEYLKSLFLGEEIDVEEGEETHSFNTKYLEFLHYEDKAREILGERFDFVQFKREFWQMLGVERESLKFESRLIRQTPSERLEEIWPQFEEQLKNRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F1</accession>
    <name>I2F6F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07504">
        <property type="protein sequence ID" value="AFK07504"/>
        <property type="gene ID" value="Theba_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1854"/>
    <dbReference type="HOGENOM" id="CLU_3404330_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="30" mass="3431" checksum="09217AEC26B6D940" modified="2012-07-11" version="1" precursor="true">MKTIVMIFFFLVFFVAVPGLTLRAGKEAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F9</accession>
    <name>I2F6F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative intracellular protease/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488314.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1862"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="AFK07512">
        <property type="protein sequence ID" value="AFK07512"/>
        <property type="gene ID" value="Theba_1862"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1862"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_0"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="176" mass="19221" checksum="756AC1D0252D2087" modified="2012-07-11" version="1">MRLEGKKIAVLVEDGFEDLEFWVPVMRLREEGAEVVIAGREKGILFLGKSGLEAFSDSDFKSIDVSKMDGIVIPGGWAPDRLRRFEEVKSLVRDANERGKVIGMICHAGLVGISAGIVRGSKAVGSEGIKDDLINAGSVWVDEPALVDGNLVWGRVVKDIPDFCRKLVETLENGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J3</accession>
    <name>I2F6J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731348.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1898"/>
    <dbReference type="EnsemblBacteria" id="AFK07546">
        <property type="protein sequence ID" value="AFK07546"/>
        <property type="gene ID" value="Theba_1898"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1898"/>
    <dbReference type="eggNOG" id="ENOG50337CQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382696_0_0_0"/>
    <dbReference type="OrthoDB" id="1883044at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032604">
        <property type="entry name" value="DUF4897"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16238">
        <property type="entry name" value="DUF4897"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="22050" checksum="ABA8B02022C80020" modified="2012-07-11" version="1" precursor="true">MKFNTLLIILVVVMVGMTAINMFMAFNNRLDIDTLSSTSNYSYDYEGRATLDIETEIIFNKPDQMTQFLEQYDKPQEEQLADFQESMTQFSESFDRLMLVESFQSTATVLSSNRVKVVEHAVIAGFAAVENGVVNTDMGDMEFDLTGDAYSLTISIPTDAKVINLDPAPTVAADGNEFIWTNTGKTIFPKIQFSRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K6</accession>
    <name>I2F6K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease, Rne/Rng family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731361.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1912"/>
    <dbReference type="EnsemblBacteria" id="AFK07559">
        <property type="protein sequence ID" value="AFK07559"/>
        <property type="gene ID" value="Theba_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1912"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_3_0"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1" evidence="6">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="490" mass="55162" checksum="DF942DDDD49B4974" modified="2012-07-11" version="1">MARIQNNRTQTIVFSRIEDEVRIASLDGDQLEEIFFEDMDSESVTGNIYLGKVENVVPSLEAAFVNIGIGRNAFLRFKDASGQPKLEKNNKVLVQVSKDPIGSKGPQITLKVSIPGRSLVYTPFSKHIGISKKITDQQERQRLTAVAKSTLENKEGVIFRTAAFGVGDETIKEELESLRTNWNQICETFRRSRKPKILYEEPSFVEYILRERLTENTKEIVVDSEELWHDVVAGISKFKSGFKPVVRYVEGDAFASEEVYEKMKILYTRMVSLPGGGNIYIDRTEAMTVIDVNSASNVSGNDVSETSLNTNLEAASEIARQLKLRNIGGIVVIDFIDMKSDEDRQKIISSLTGEFKKDKARTMIMGFTRLGLLEMTRKRSSAAIGSKLYSSCPICKGTGRIESPRAVYQRLLKDLARGFEDETISSATVQVYQNMSGILTPENQKNLAKSLKREVSVGFTWPIPTSYEIKFAKKQDKPKRTRRKTKKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M9</accession>
    <name>I2F6M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731384.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1937"/>
    <dbReference type="EnsemblBacteria" id="AFK07582">
        <property type="protein sequence ID" value="AFK07582"/>
        <property type="gene ID" value="Theba_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1937"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_5_1_0"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="134" mass="15504" checksum="FB800E0A9CF8FD75" modified="2012-07-11" version="1" precursor="true">MKRLTSLRREVLDLINNSESPLSADGIYGALKEKPNLSSVYRSLAFLEDEGLIRSISFECETRFYFSSEREPVHFLHCKKCHKTEPFYECFADSFAKKVAESRDFTITNHVFYFIGICGECKRKLLSDIEDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N6</accession>
    <name>I2F6N6_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">Theba_1944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1944"/>
    <dbReference type="EnsemblBacteria" id="AFK07589">
        <property type="protein sequence ID" value="AFK07589"/>
        <property type="gene ID" value="Theba_1944"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1944"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="339" mass="38943" checksum="3E352E716CB13539" modified="2012-07-11" version="1">MNENIIEVKDLQKWFPIRRNISQFFKGEHNYVKAVDGVTFSIKRGEIFGLVGESGCGKTTTGKLIMKLLEPTGGTMFLNGKDVTHIEKDELKIYRRNVQMIFQDPYASMNPRFKIRDVMEEPLIIHKLGEDRDERMKMIEKALREVKLNPPDEFLVRYPHMLSGGQRQRAATARTLLLNPELLVADEPVSMIDLSTRAEILHMMKEVQRDLGLTYLYITHDLSTARYFTDRIAVMYLGKIIEIGDPDDVIDNPVHPYTRALIAAVCEPVAGKVNKPKIVPIKGEIPSAANIPKGCRFHPRCPYAKEECWEKEEPQLQEIEDGHFHACRRWKEVADENRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N7</accession>
    <name>I2F6N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1945"/>
    <dbReference type="EnsemblBacteria" id="AFK07590">
        <property type="protein sequence ID" value="AFK07590"/>
        <property type="gene ID" value="Theba_1945"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1945"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="36372" checksum="6BF6C9C6A33C1980" modified="2012-07-11" version="1">MDNILTVENLKLYYYTSKGVVKAVDDISFTLKKGETLGLVGESGCGKTTTGFALLKMPTPPGKIVGGRIEVDGIDITPLRENEMRRNIRWEKISMVFQGAMNTLTPVYTIGKQMMETLQEHREMERDEARKRIEKYLNLVGLSGDIVKRYPHELSGGMKQRIAIATALFLEPKVIICDEPTTALDVIVQAQIINLLKDLKEKLDLSFIFITHDLATEAEVSDRIAVMYAGKIVEIGTNQQIYGEQGPCHPYTRNLLAATPRLHERVSELSFIPGAPPDLLEPPSGCRFHPRCSLAMDKCKEEEPPLIEIEDEHMVACWRCEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P0</accession>
    <name>I2F6P0_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1948</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK07593"/>
        <property type="gene ID" value="Theba_1948"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1948"/>
    <dbReference type="eggNOG" id="COG3506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082825_0_1_0"/>
    <dbReference type="OrthoDB" id="1485526at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015987">
        <property type="entry name" value="UCP022704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="PTHR35332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022704">
        <property type="entry name" value="UCP022704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="194" mass="22227" checksum="C2B43D6BE7BCEC19" modified="2012-07-11" version="1">MQLSSFGEGTIKHFTWLNEPKRWELQDGNLIVESEESTDFWQRTHYGFRNDNGHFLFVPLMEDFSFVLGAKFFPVNQYDQAGVMVRVSPSCWLKSSIEFEGSAPSKLGAVVTNSGYSDWSTQDVSCETRSLRVKVDRKGSDYSVFAWQDEWVQLRLARLIEDDCKLPVMVGAYCCSPRGSGYRVVFDEISLNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S4</accession>
    <name>I2F6S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731419.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1984"/>
    <dbReference type="EnsemblBacteria" id="AFK07627">
        <property type="protein sequence ID" value="AFK07627"/>
        <property type="gene ID" value="Theba_1984"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1984"/>
    <dbReference type="eggNOG" id="ENOG502ZAP1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596911_0_0_0"/>
    <dbReference type="OrthoDB" id="1533893at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="446" mass="50100" checksum="69FB705DC9999D5E" modified="2012-07-11" version="1" precursor="true">MKKTLLITLLLGFMLFVSGCFKINNPPVISLTGSVSEGQEIAPMTLVTFEWEITDFDDTEVTSEFKLYRNGAEVLSVVDTGEAMYALDEEGKYVAEVVATDSMGAQSKETISFKATNLKRELFQSGAGLMYFDYSDYFQYIEDEAFGIRFYKTASEEILPAEEVTVRKRLNLLDTDDDGMYDTWEEIPNDRPDLQTYVYLPGYLIDYDTLWVPYGFEYGEKSIRAYYAGVEGPYSGYVLFYKFAEVGFDLNTVYARWVEAHVFGNTLNDYGEAYKAFALRERYDSDEKPIISLSTPDGDIGPGDSFTVSVLTENVASFADLYDVRYVQLSLWNSEGLVLEGVEFGNFMAGLKDVGTFKSSDEAVTLYKAFLNGVDEAEAADDVFATLTFSVPEDFEGELIAVGLAYEGYWDTYGTYPDLPNPAFRDVDNGSVDGFIVDHEPIVFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V9</accession>
    <name>I2F6V9_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07662">
        <property type="protein sequence ID" value="AFK07662"/>
        <property type="gene ID" value="Theba_2019"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2019"/>
    <dbReference type="eggNOG" id="ENOG5033JXB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675811_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="17545" checksum="16284AADC9B5F5A0" modified="2012-07-11" version="1">MILHSKSSMTDAYRSLLTPLLSKISGIDEVYLFVSLGKPVESILKEIGFKVEGYSFVLKRRLISSSLETPEEIDFTTFDLEKHGETFCKIINSAFAKLAGHFDIDPNWLKSNLSISTVPDSGIQLLYKENEPVGLFFSEINSERLLEIGPLALLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X5</accession>
    <name>I2F6X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07678">
        <property type="protein sequence ID" value="AFK07678"/>
        <property type="gene ID" value="Theba_2036"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2036"/>
    <dbReference type="HOGENOM" id="CLU_2479744_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="87" mass="9879" checksum="56CE39D67221D0A7" modified="2012-07-11" version="1">MIIVKHSCMLEFTRELKRSHKPLPNPVKTGMICNRKYVLLTLPVRVIKLPKTVQFGFNTISVSEIDPEFKPAPQSQMNPMISEGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F701</accession>
    <name>I2F701_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731481.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2066"/>
    <dbReference type="EnsemblBacteria" id="AFK07704">
        <property type="protein sequence ID" value="AFK07704"/>
        <property type="gene ID" value="Theba_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2066"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_0"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="8"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="317" mass="35209" checksum="5BBB4DD3F017D300" modified="2012-07-11" version="1">MDKIFFTYKIPDEGLLLLKGYDIMINTEDRFLSKEEIIQKAKDAVALVTLLSDKIDAELIKSLPKLKVIANYAVGYNNIDVEEARKRGVRVTNTPDVLTDATADLTLALILATSRRIVEGDRFVREHRFAGWKPDLLTGPSLKEKNLGIIGLGRIGRAVAKRAQAFGMKVIYHNRKPLLTEEEERLGVNYRSLEELLKESDFVSIHVPLTRETHHLLNEKRLSMMKPGAILVNTARGSIIDEAALIKTLKNGRLAAAGLDVYEEEPTVPQSLIDMDNVVLLPHVGSATREARTEMAIMVGRNVAAVLEGKEPPNAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F705</accession>
    <name>I2F705_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2070"/>
    <dbReference type="EnsemblBacteria" id="AFK07708">
        <property type="protein sequence ID" value="AFK07708"/>
        <property type="gene ID" value="Theba_2070"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2070"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="65"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="391" mass="42868" checksum="306B24FD0EAFD51E" modified="2012-07-11" version="1">MRETKMICTMCGKEYLGEHFRCSCGEPLEIVIEKKTAVNISWRKSGILESFSDLLPELKDFNSLSMGEGLTPLTKIEHAMTDGLELFIKNETINPTWSFKDRGSYLAVLDAINKGYKHIGTVSTGNMAASVAAYSMRAGLKTTILISDSIPEEKISPIAIYGPRILKVKGDYDRLYFKSLELGKKKNIYFANSDIPMRVEGSKTIAFEIFLQLEGRVPDFVIVPTSSGGNVRGIEKGFRELKACGLSNSIPRMIVAQALGCCPIHQAFSSNDNQIEKFAHAHTIAHAIENPFPPSGNAVLRMLKENQGITVAVNEDEILTAQRQLAKRGLFGQPASAVAFASISKLRKEIGVKRAIVVAVLTGSGLKYPAILKEQPSVVEVTDIDSLQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F711</accession>
    <name>I2F711_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731491.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2078"/>
    <dbReference type="EnsemblBacteria" id="AFK07714">
        <property type="protein sequence ID" value="AFK07714"/>
        <property type="gene ID" value="Theba_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2078"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="326" mass="36622" checksum="D72DCC731F875AAD" modified="2012-07-11" version="1">MKTKISIREVAERAGVSTATVSRVLNKSLYVRPELEEKVIRASRELGYVPNRLARGLRIGSSGMIGFLIPDIVNPFFSEIVKGAEDYLREKGYFIFLASSSGDSLKEEELLKALYSRNIEGIGAIILGELPEFVRSISSNLPIVIIDNYQDWDEVSYVFSDNYDGMKKMMNYLIRGGHKSFAFLNGPANTFSSRERLRAFEDVISEENRSFEIHFGDYTFESGRDMLRKLKRIPDAIVCGNDMIAFGAIMELTEMKYDVPGRVSVTGFDDILFSSMTNPKLTTVRQDGYAMGRVSGEILLRKISGQKTNHKILLKTSLQIRGSSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F734</accession>
    <name>I2F734_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative stress-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487862.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2103"/>
    <dbReference type="EnsemblBacteria" id="AFK07737">
        <property type="protein sequence ID" value="AFK07737"/>
        <property type="gene ID" value="Theba_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2103"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099432_1_0_0"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="15905" checksum="DBF043F6126069D2" modified="2012-07-11" version="1">MSDTKRLYKSRKDKVIDGLAGGIAEYLGVDPVIVRLVFVALIFAGGAGLIIYIIGMFIVPRAPINSENNVVIMDEEGKPIEEGKKEEFSDSKSKLIIAALLIVFGIALLLGSFTPWNIFSGIFWKTVIGVVLIAGGGFVIYKSINRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F789</accession>
    <name>I2F789_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731560.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2159"/>
    <dbReference type="EnsemblBacteria" id="AFK07792">
        <property type="protein sequence ID" value="AFK07792"/>
        <property type="gene ID" value="Theba_2159"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2159"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2906">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_1_2_0"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="605" mass="65437" checksum="1F94B9444703EA58" modified="2012-07-11" version="1" precursor="true">MSNLDLLVIGGGPAGLSSAIEAAKNGLTVLVVDEGISSGGQLVKQTHKFFGNESFFASVRGFEISRRLTEQLNSLDSAKLQNESSVVAIYPDGILVHDMKNDHTSLLKPKKIILATGASERFIQFENNDLPGVYGAGAVQTLMNQFGILPGRSVLMIGSGNIGLIVSYQLLQAGVEVKAILEASNRIGGYQVHADKVRRVGIPILLQHTILRAIGEESVRGAVISKLDERWSPISGTERELVVDTICIAVGLLPSIELAAQAGCEMKYVQELGGYVPLRDEDMRTSIDDIFIAGDAAGIEEATTAMIEGQIAGLAVVSDLTKNSIQERLKYLKDTLRKFRSGPTSSKTRAGLSKLGSKFEEVSFTNGNQNDFTKYTGKMRPLIECFEAIPCNPCETSCPAGAISIGDNINSRPIIDYSKCTGCGICATTCPGLAIFMFRENKDGTCSVGIPYEFLPLPADGQYVTALGRNGETICKAKVEKVVKSANKTNLVYIRVPREYASDVRHILVPSKESGAMVCRCEEVTVDQVRKAIKDGYTDFEELRRYLRIGMGPCGGRTCRLNTLMILSEETGVPVERLSPGVFRPPSIPVSFKALGEGRVDGYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A1</accession>
    <name>I2F7A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2171"/>
    <dbReference type="EnsemblBacteria" id="AFK07804">
        <property type="protein sequence ID" value="AFK07804"/>
        <property type="gene ID" value="Theba_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2171"/>
    <dbReference type="HOGENOM" id="CLU_3154688_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="48" mass="4948" checksum="3B8559027F02FB50" modified="2012-07-11" version="1" precursor="true">MKKVAAILLIGLIALGGVTLAGPGLWKIPEGEFTVDGGPGLWKIPEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G6</accession>
    <name>I2F7G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="1">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_2239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="7.2.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731628.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2239"/>
    <dbReference type="EnsemblBacteria" id="AFK07869">
        <property type="protein sequence ID" value="AFK07869"/>
        <property type="gene ID" value="Theba_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2239"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_1_1_0"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="870" mass="94547" checksum="85905FCB8BEBEA70" modified="2012-07-11" version="1">MAWHSLELEEVLEKLNVDPNKGLSSSGVEERLARFGSNILREERKKTIFERFLEQFKDVMIAILMAAAAISFVVSLFENEGFFEPVLIMLIVVLNAVIGVIQESKAEKALDALKKLSSPNAKVIRDGEQRIVQASNVVPGDIVLVEAGDFVPADARILSSASLKVDESALTGESVSSEKKTEAKVKEDATLGDRFNMIFSGCSVTYGRAKAVVVETGMQTEMGKIASMLSAEEETETPLQKKLNVLGKYLAIAAIVACAIIFLVGLIDGIPIMEIFMISVSLAVSAIPEGLPAIVTVVLAIGVQRMVKRNAIIRKLPAVETLGSATVICSDKTGTLTQNKMTLVKAFSDYDSTLEEISSENLPEIRSLLLYATLCSDGRIIYESGEEKQIGDPTETAIVFAAKRNGIEKEKIEEKYPRLAEIPFDSERKMMTTINRIENKNVVITKGAIDSVALRCVAGDVEKGRRIAEEMGSDALRVLAIAYKHIEEIPEILDPAEIESGLTFMGLVGMIDPARPEAKESVALCKQAGIKPVMITGDHKLTAAAIAREVGILSPEEKVVDGSELARMLDSELEERVRDISVYARVSPSDKLRIVHAWQKQGEVVAMTGDGVNDAPALKAADIGCAMGITGTDVAKSAADMTLTDDNFSTIVEAVKEGRGIYANIRKVVGFLLGTNIGEILTVFAAMIIWREAPLISAQLLWINLVTDSLPAIALGMEPVEEDVMKSKPKRKNEGIFANGLGYRVILQGIMFAFLTLIGFSIGWKSTGDIVVGRTMAFAILSLTQIFHSFNMRSNHSLFKTGLFSNVFHIFATVVSLAMVAFVLFIDPVARIFGLAELNASMYLLAILLSLVPIPVIELEKLAGVMRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P1</accession>
    <name>I2F7P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731698.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2317"/>
    <dbReference type="EnsemblBacteria" id="AFK07944">
        <property type="protein sequence ID" value="AFK07944"/>
        <property type="gene ID" value="Theba_2317"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2317"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343068_0_0_0"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="103" mass="11987" checksum="712417A6ECCE9DC2" modified="2012-07-11" version="1">MGNLRDERIIRELSQRELGEVIGKDQKYISEVELGRIIPCFRKADTLARFLGVPVERIFPCFTRTSRFPGYKDLMYLYSLGYDIAVYENAMRELTTKEAQNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S1</accession>
    <name>I2F7S1_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490052.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2349"/>
    <dbReference type="EnsemblBacteria" id="AFK07974">
        <property type="protein sequence ID" value="AFK07974"/>
        <property type="gene ID" value="Theba_2349"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2349"/>
    <dbReference type="eggNOG" id="ENOG5030M0C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077332_0_1_0"/>
    <dbReference type="OrthoDB" id="1865816at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032580">
        <property type="entry name" value="SatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16264">
        <property type="entry name" value="SatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="207" mass="23063" checksum="BAB2483BE3B76392" modified="2012-07-11" version="1">MGLYAVITADIIQSRKQVLPFERIEQTLASFAGEHLVKSFALSRGDEIQGVVSDLSVIVSLVRRLRYVMWPLALRVGMSIGEIEDDKLKKAGTSWDLSGEVFFSARDALDMAKKSRVSNTFFLCSDELLSTALNTSLSLLETIESGWTEKQWQAVHVYEREGTYEKAARVLGVTAPAVQQHCDKAGWNVVRVAEKELARLISLSLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X5</accession>
    <name>I2F7X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489927.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2412"/>
    <dbReference type="EnsemblBacteria" id="AFK08028">
        <property type="protein sequence ID" value="AFK08028"/>
        <property type="gene ID" value="Theba_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2412"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122305_0_0_0"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="158" mass="18051" checksum="48A2D0FF16E55034" modified="2012-07-11" version="1">MIVIEKMRSDEFSVYLRKLVENYAVENVKSGRWEEKSALEKSKREVDSLLTDGLNTENHELLNLKEKDTGKKIGCVWLHIFPGMEKKGFIYDFVIDEAFRGKSYGKESLKALEEYASKLGVEDLSLHVFAHNTVAVALYRKMGYEVTSLNMAKHIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y0</accession>
    <name>I2F7Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731773.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2417"/>
    <dbReference type="EnsemblBacteria" id="AFK08033">
        <property type="protein sequence ID" value="AFK08033"/>
        <property type="gene ID" value="Theba_2417"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2417"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="259"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="464" mass="51658" checksum="2E5BDB838C111D8D" modified="2012-07-11" version="1">MRIGDMKSSFNEFWQEFRRVKSGMIGLVFLGLFLMVLFFEPLLLPFEGANQRWKDITYWEDNPASAAPQWTNLFSSKKSAVSIALESAKKEEKNAGPIRIIEETFVYDFQYDVAPSDIIFRASGKANPTAIISIERPDGRKIDLLRKPLEVTEGNDLRIAIDKTSLNEAYNFLKGLDAATGLSKQTMKTTDIIFSKVEDSVPFKPEALKGEYRIMVSLILQKETDLIDSTEMKIAGRVHGILGTDNSKRDIWSGVIAGVKWAMLIGLLTALISVSIGVIYGVMSAYLGGWKDSLMQRIFEIFISVPMLPVLIVMSAVFKPNIWMIIAIMCIFYWVGPVKTVRSMGLQIKEETYIEASRALGASNTRIIFKHMVPLLIPYAFASMALNVPGAIVVEATLSLLGLGDPNIVTWGQILQDAHNGGAMLSGMWWWVVPPGLAIAFMGMTFAFVGFAMDKILNPKLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F843</accession>
    <name>I2F843_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase-like glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731828.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2485"/>
    <dbReference type="EnsemblBacteria" id="AFK08096">
        <property type="protein sequence ID" value="AFK08096"/>
        <property type="gene ID" value="Theba_2485"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2485"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_0"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="605"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="685" mass="75789" checksum="D7D3EC4B1008DA7B" modified="2012-07-11" version="1">MKRLSDMTLEEKIGQLVMYGKYGEAQQKALAEGRIGSFLNNRGEETQMRQNLALDSPTGIPLIMGDDVIHGFRTIFPIPLALSCSFDLGLIEETCALSAREAAMEGINMIFAPMVDISRDPRWGRVAEGAGEDPYLGSEVARARVRGYQRNDWEDLPKTAACAKHYVAYGAPQGGRDYDGADISERSLREIYLPPFDAAVKAGVMSVMSSFNDLNGIPVSGNERAIRGILRGELGFGGVVVSDWESVEELVNHSIASDGREAARLGFKAGVDIDMNSGVYERYLKELVREGKLTVEEIDQAAGRVLKLKERLGLFGKKRFRIEDARRLSLENLAAKELALKAARESIVLLKNRDLLPLRKGTKLAVIGKLADDRPDMLGCWAGQVEVQESVTVLEGLENLGEEFRYERGCEINSDIEGGIDRAREIASKVQVVLMVLGETSSMSGENRSRADITIPAAQRRLLRSVMEVNENVVLVVVSGRPLVLSWEEANVPAILQLWQPGHQAGNALAEILYGIHNPSGKLTLTFPASVGQIPVYYNRKNTGRPLFKKYIDIQDEPLFPFGWGLSYTDFDYEDLALSSGSPKMGEELKVSARVTNRGDHDGSETVMLFVRDVTASVTRPVMELKGFEKLFLKAGQSKNVQFDITGEMLSFLDENLKPALEKGRFEVFLGRNSVEHLKGYFELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F898</accession>
    <name>I2F898_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731876.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2550"/>
    <dbReference type="EnsemblBacteria" id="AFK08151">
        <property type="protein sequence ID" value="AFK08151"/>
        <property type="gene ID" value="Theba_2550"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2550"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787099_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="203"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="352" mass="40113" checksum="D147803CCCE25EE9" modified="2012-07-11" version="1">MEPIRVYIVDNGTAEIKTLSERISKLRWNMHVETVSEDPLVGETSWSNKFYTLNKYLKRKYEGFASLIDDMIFLVSLDDPMRPGRIVEANNSAAEKLGYSYDELLEMSFYSVAGDLDSQIKKIRADLQIKGMCTTDSFLTMKSGEKLQVEICLKVLDLQNSIVTMVVARDTSAYRKVAAELQWRQNFERVISEVSGALKEYENIDDAIEKALGQLGELTSADRSNVFLFDYRTNSTRNTHEWCKEGVKSAKPHLQNMPFEEFSWWIKEMKKGGVHSYVVSELPEEASREAEILAQQGVVSLVVIPIFSRQMPVGFVGLERLSGQFDWSRADIELLEVFAGLISGVIEYSRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B0</accession>
    <name>I2F8B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731883.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2563"/>
    <dbReference type="EnsemblBacteria" id="AFK08163">
        <property type="protein sequence ID" value="AFK08163"/>
        <property type="gene ID" value="Theba_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2563"/>
    <dbReference type="HOGENOM" id="CLU_632841_0_0_0"/>
    <dbReference type="OrthoDB" id="1936887at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="433" mass="48348" checksum="1C6AD8751F2A5F93" modified="2012-07-11" version="1" precursor="true">MVGFLFYFGRTKAGCSIYFVLPVLLFTTTILLIGVLRTDVVQSLSALGSIVGVILSMDRSVRLAVPGLFMVGVSLSFSPNLFQTGAYITLAVILVRLLMTRNVPRLFLLLSILIPLLSLSLLGNYRGGILSNEERTSTANLVESEKELFPEEGLTKDATVLTSRPSSRGSADDFDFLVLEEVAEVRLIDSVFLFGFYTIALILVIVVSRKAILEMGRWSRLIPPSIVLLSIVAVLIGGFMYLRSLPLSEEIVLGTGGPSNQTSFAPSQSVTGLPEENEEDEPEAILNKSAAYNILRWSTLAGILLLSALLAYFVTVIARKNQTVSSTLKSKDTILTEVRQSASVPPKFSEDREFIISSYKWLREFYFEEYCQLTPFELIQETEASLKHLLIELTEIYVPVKYGNLEPEIYQCREFHKLLLGLKELLDRKKRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8B1</accession>
    <name>I2F8B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731884.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2564"/>
    <dbReference type="EnsemblBacteria" id="AFK08164">
        <property type="protein sequence ID" value="AFK08164"/>
        <property type="gene ID" value="Theba_2564"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2564"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_666904_0_0_0"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="196"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="423" mass="48708" checksum="6E6A7F4FF213879F" modified="2012-07-11" version="1">MKRLELEEIRSRKGPLIIATGFSVGWSLFFFNVYSAMFLTLSAVVWIYYYLSKLILKNLTIDRSVDRERLFPGETLTLVHNIQRVPFISLSLTVIPVIRAEREYAAPRESSISLSSTEDSRVESKVVFRRRGEKDLSRLIVACRDPLGLFSHSATYYTPQSVLVLPKVMDLETFPLRLRELLPGRESDFRLMEDPIDFKGIKEYERESLNRIHWNASAKLGKLMSKEFGYTAVSKTVLYLDLNLSREVFARDVWERIRIDYEEIAVQLALGLIRLSYRSGGSIRLVSVGEEVLRLSDRGRDWIDFAEALSNTKGIDHGSQLCEIIEDDLEQFDPSTTVVLISLYLGEEILPQLLRARSHASRVVVLIIPFSPREPWMKRNVSYQMLPKTIDELKKRAAFLEEEQIIVRVVGDDQSIQEVLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D1</accession>
    <name>I2F8D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731901.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2584"/>
    <dbReference type="EnsemblBacteria" id="AFK08184">
        <property type="protein sequence ID" value="AFK08184"/>
        <property type="gene ID" value="Theba_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2584"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="255"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="507" mass="56496" checksum="165CBBC252C31795" modified="2012-07-11" version="1">MPEEKTVIELEGINKTFPAVRALDNVSLSVKSGEVRGLVGENGAGKSTLIKIITGAYTKDSGTMIFEGNEITRNSPLISKGLGIYAVYQDVMVTPDLSVAENFFLGQQPKIGPFINWKKMYKESMEFLENIGLDINVRKSIKELSIAESEMITISKALWQKPRLVIFDEPTAVLTRNETKILFQIIDELKNQGTAVIYISHNLEEVFDICDTVTVLKDGATVGTYTTEELENVEKLIPLMVGRSIEEMYLKKDTEPGRELLRVENLSGERFENISFHVRAGEVVGFFGLVGAGRTEIARALFGADLLKEGKIVVEGKDVSIKTPKDALMKGIGYLPEDRRKQGIFLQQDIDFNINIINFDKVMTGPIINYGKAHSQAREYIDKLSIKIGSIFQPVSELSGGNQQKVIIARWLCKNTDVLIFDEPTVGIDVGTKSEIYKLFGEILSSNKGIILISSYLPELMGMSDRIYVISNGRMAGEVHKKDFSEEFLLTLAMKNIVSREKVKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G8</accession>
    <name>I2F8G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2621"/>
    <dbReference type="EnsemblBacteria" id="AFK08221">
        <property type="protein sequence ID" value="AFK08221"/>
        <property type="gene ID" value="Theba_2621"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2621"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645428_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="47828" checksum="D00C6D9F4E0474B1" modified="2012-07-11" version="1">MSMMKKEFMWIAGIEDTFVTKTDRTSARSLDEYELTQHYSNWEGDLEIIADTGFKYVRYGIPWYTVNPEKGRFDFSWTDRVFDFMGERGLIPIVDFIHYGTPHWMDNGFLNSCFPDYMADYELEVLERYKKSIDLFTPMNEPFITQEFCGRQSIWPPYLSGDDGFVKLLIATAKGIMKSVSSIKRELPNKYALHVEASGIFFSAERELQEEVKKMNEMRYLTYDLIQGKVDTKHCLFDYLYKNGVGSEDLDWFTENRITVDGFGVNYYPQLSVFEVSKEKGKIRTTPFYGGTEYLEKLIVSYHERYGGPIFLTETSINGEPDHQILWWRESLKLVEDLIDRGIDLKGYTWFPAIDLINWDYRYGSEPVEKYLEPMGFVSLKMDPFRQFRRSTGELATVMRNDLRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H8</accession>
    <name>I2F8H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731938.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2631"/>
    <dbReference type="EnsemblBacteria" id="AFK08231">
        <property type="protein sequence ID" value="AFK08231"/>
        <property type="gene ID" value="Theba_2631"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2631"/>
    <dbReference type="eggNOG" id="ENOG5030YAD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085039_0_0_0"/>
    <dbReference type="OrthoDB" id="1092932at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="30233" checksum="6CD30BEEFDE4F1B5" modified="2012-07-11" version="1" precursor="true">MKIRLVLIVVLLIAVVSSAGLLNNPENRFKLELDYEIGFTGVIFHTIQFGQTGTVLNYVKDGGQDVLFPYQRYTAGLSIGKHTVYFLYQPLTVQSKVQLKNDLIVDGVTFPAGSGILLNYGFPFYRISYTYDVLRKGNSYLALGLSLQLRNADIYFDSLDGTKFVDNKNVGPVPIIKVKGAYWLNEKVYLATDIDGFYASSSFINGADFDFEGSVLDASLRAGLLLTDYLETYFNVRFIGGTAKGTSENSDSPDGFTDNKLATINFSIGFQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I0</accession>
    <name>I2F8I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731940.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2633"/>
    <dbReference type="EnsemblBacteria" id="AFK08233">
        <property type="protein sequence ID" value="AFK08233"/>
        <property type="gene ID" value="Theba_2633"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2633"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_7_1_0"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="204" mass="23730" checksum="146EE7DEB4BAD0DD" modified="2012-07-11" version="1">MNGPRRVSEEEYEKAVEILTEAFFEDPMIKYVFKDRERKEIRRLYGVMTKAYAPSSDIYFDSEESSGVIQWIDSEKELGVMAWLRSGAMRMIGSPISSLFRLMKTGMEIFKTQKECMKGHNLHLILLAVLPRKQGMGIGKKLMNLFIQEADSRGLPCYLETQNPSNLRFYESFGFSVVKEIEISLELRSWSMVRPIPLQEHENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L6</accession>
    <name>I2F8L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731965.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2670"/>
    <dbReference type="EnsemblBacteria" id="AFK08269">
        <property type="protein sequence ID" value="AFK08269"/>
        <property type="gene ID" value="Theba_2670"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2670"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_0"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="945" mass="108309" checksum="4E1781CBEEC81BFA" modified="2012-07-11" version="1">MRVTSIDLENFRSHSRYSETFEKGINLILGRNGSGKSSIIEAIGLALFGGGLRDKQEDAIKWNERRSRITVTFLADDGLEYRVEKVFGTGSSHELHQGDLLIARGKENVIEKIRIICGLQGDISKTFENVIVAFQNRIADQFLGSPAARRDYFNRVFQVDLYRKISTDFMRSYLTDLRNENEAIEREIAFMEQQLERKAEVEERVKTLSGDLSRAKEELKSLEDALNKVKAERLRLEEIGRELSSKRAQFEQQMKSLRDEAASLKGNLRQKERAVEAKEIVDRSREGHDLYERLLEKENVLSAEKRRLEGLGERSAAIEKRIAELQTEVARLSGALSNSEERLEESEKQFEELKKEREELRVKMEEAEREGGKKRETHNLSISRKEAFKVIIEEYRKPERRLAALEDLLRSLGKPEGSEELNERLTKIDEIIERVKQEVLLLEQLNEDIVSMASRRKALVEYRGSLAVGICPLLDEKCKNIENRRDYEGYIEGLINQLASGERELSKKIAEVKESPARLGKLAEERALILNTIEETDRKLKEKSNLEKEKLDLTERVNSFLLQLSTISGVSGEIDEMSESVEEDIRNTSTELELQKKHISTLKNQIEERDSRLEEIKSRIKSLNELKKKTEEEVTSRSSESDAQKSIVKEFAEELRKLPGLRAEIEEIRRAMVINRSDYEGFNKYVNLAGYLEEYSSLCRASLERCRKKAAGVTGLRKEIIALEKSFDYDRLEELKAGEKKAEESYALKRDETISIGRDIVSLRAELKNFAEMEEKKKLKKRAGEKTSRKIKLSEMIRDNLNLTGERITAGFRDAIEQKATLDYQRISGTEESIRWNEDYEVSVKASEYGDGSVRSFSNLSGGEQVLVSLCLRAAMTGVLSGARFAVFDEPTSNLDKERKELLAHSLRELFGELDQSIIVTHDDVFSEMAQKVIRLNGRDKGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M1</accession>
    <name>I2F8M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487289.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2675"/>
    <dbReference type="EnsemblBacteria" id="AFK08274">
        <property type="protein sequence ID" value="AFK08274"/>
        <property type="gene ID" value="Theba_2675"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2675"/>
    <dbReference type="eggNOG" id="ENOG502ZM8D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1446099_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657699" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="187" mass="20347" checksum="8FF04F9894640BDF" modified="2012-07-11" version="1" precursor="true">MKKVALVALLLFAVSLGFSTPKALIGGAFGINATNPVYQPERWGAGAFDLSLQLPFTDKIGAMLSAQAAIRYPSNKIGLFNADIYFQIFETLNLKARLLVSVGSVQDSNFGEQSWEIGILDLGAPHLAIGGGFQVMTPISDKVILNGFARGYRVKDYQTRQEGDFPGGDYWPLPEFFSVGLGVLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H6</accession>
    <name>I2F1H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729959.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0024"/>
    <dbReference type="EnsemblBacteria" id="AFK05779">
        <property type="protein sequence ID" value="AFK05779"/>
        <property type="gene ID" value="Theba_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0024"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046680_0_0_0"/>
    <dbReference type="OrthoDB" id="595291at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004729">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01319">
        <property type="entry name" value="glmL_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="456" mass="49409" checksum="3BA3927F488BB790" modified="2012-07-11" version="1">MKVEFLTAEIGSTTTVLSAFSCDASGSMRFVGQGESYTTVNENDVTIGIDNALRNLKRSLGCDNLEWSVFLASSSAAGGLRMTVHGLVYDMTVKAAREAALGAGGVIKLVTAGKLSERDLKKIEAANPKLILLAGGVDYGEKETVVHNAEILRDLDQNIPIIFAGNVAAADDVLEIISTNGRDVHIVDNVYPRIDELNVEPTRQVIREVFSKNIVNGPGMEKVYSVIDKPIIPTPAAVMLATELFSQVNDDVIVVDIGGATTDVDSVTDGDPEIASILLAPEPRSKRTVEGDLGIYVNASHVIEQIGRDELGKEFPDLENILRNLTPYPKNDRDEAFSLRLAAYCFETSIRRHAGTIKQLYGPTGRTEVAYGKDLTAVKSVIGTGGILSRSKFSSKIMKIVRTLSAKHEKELLPKSSVRLFRDRNYIFGAVGLISTVDLPSARDLVENSLEELNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J8</accession>
    <name>I2F1J8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729976.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0049"/>
    <dbReference type="EnsemblBacteria" id="AFK05801">
        <property type="protein sequence ID" value="AFK05801"/>
        <property type="gene ID" value="Theba_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0049"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_0"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="102"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="441" mass="49437" checksum="A36B37AF7603270C" modified="2012-07-11" version="1">MTEKELIQKCESGEIGFVRLQITDINGMLKNVEVPARMLPTILEKGAMFDGSSIDGFVRIEESDMYLRPDLSTFAFLPWDNCQGKTIRLICDVYKPDGTPFEGDPRYVLKRVIQRAKSMGFETYAGPEPEFFIVKRDHDRGKPIGAFLDTGSYFDLLPVDGGEEVRKQIVLSLQEMGFEVEAAHHEVAPSQHEIDFRYTDILKTADNIQTFKWVVKTIAIADGFHATFMPKPFSGVNGSGMHIHMSLFSDGNNAFYDSSKDHGLSQTALSFVGGIISHAKEITAVTNPTINSYKRLTPGYEAPVNISWALGNRSAMIRIPSTRGEGTRLEFRSPDPTCNPYLALALTLAAGLDGVEKRIDPPNPVDENIFKMKGSRRKELMIENLPGTLINALEFTRNSEFVKSTLGDHIFNTFVRSKEGEWSEFCASVTDWEISKYLELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M1</accession>
    <name>I2F1M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA ligase D-like 3'-phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729997.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0073"/>
    <dbReference type="EnsemblBacteria" id="AFK05824">
        <property type="protein sequence ID" value="AFK05824"/>
        <property type="gene ID" value="Theba_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0073"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_5_0_0"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="200" mass="22767" checksum="787A11E2DBDDD4C5" modified="2012-07-11" version="1">MNEREEKLDKYVEKRDFSKTSEPDGREATVEWSNERPVFVIQKHAASRLHYDFRIEVDGVLKSWAVPKGPSTDPSEKRLAVPTEDHPLEYGDFEGNIPEGEYGGGTVLLWDRGSYRNLKEDPESNPLLKQIEDGHITIWLEGRKLRGGYALVRTGKGSKARWLLVKMNDEEADARRNPTATEPDSVKTGRTLEEIRDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M3</accession>
    <name>I2F1M3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Theba_0075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729999.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0075"/>
    <dbReference type="EnsemblBacteria" id="AFK05826">
        <property type="protein sequence ID" value="AFK05826"/>
        <property type="gene ID" value="Theba_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0075"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_0"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK05826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="490" mass="56178" checksum="8FA77A5CF68EF1A4" modified="2012-07-11" version="1">MENDPKKEGKLTTEAGAPVVDNQNSMTAGPRGPMLLQDVWYLEKLAHFDREVIPERRMHAKGSGAFGTFTVTHDITKYSKAKLFSEIGKKTDMFVRFSTVAGERGAADAERDIRGFAMKFYTEEGNWDLVGNNTPVFFLRDPLKFPDLNHAIKRDPKTNMRSAKNNWDFWTSLPEALHQVTITMSDRGIPYSYRHMNGYGSHTFSMINAENERVWVKFHFKTQQGIKNLTDAEAETIIAKDRESHQRDLFESIERGDFPRWTMYIQVMTLEQAEKMPYNPFDLTKVWYKGEFPLIEVGYFELNKNPENYYLDVEQAAFNPAHIVPGIGFSPDKMLQGRLFSYGDAQRYRLGVNHDQIPVNRPRNPYNSYHRDGQMRVDDNAGSTLGYEPNSYGAWVEQPEFKEPPLKLSGAADNWNFREDDDDYYTQPGKLFNLMTPEQQQVLFENTARNMGDAPKEIKIRHIGNCLKADPAYGAGVAKALGISLNEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P2</accession>
    <name>I2F1P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00341 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFK05845">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="165"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="339" mass="36842" checksum="86E66BD6CBD2FD65" modified="2012-07-11" version="1">MAERLIEVFSGSDPEKDLKEMLEEKSIIDYWTVKTSEELWQTKILALAENSEKILDSLEQRFTQDESFRAILFQVEASLPRAQEEEKEEENQATEEENKPKKGIFKRISREELYHDISEMISNDAVDIAMIVLSAIVATIGLVRNSPAIIIGAMVIAPMLGPNVAQSFATTLGDFGLLAKSVRTNLIRIGLGFAFALVFGLLFRLDYTTNEITSRTVANLGDIVLAFASGTAAALSISSGVSTSLIGVMVAVSLMPPLAAAGLLLGSGNIDGFSGAILLFFVNIVCINLASIITFRLQGIEPRSWWEANKAGKAVRVTIIGWVVVLGLLALSLFLSEVL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
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                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
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                <person name="Dlutek M."/>
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                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
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        </source>
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            <dbReference type="EMBL" id="AFK05873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="101" mass="11367" checksum="89FACB4B016EC53B" modified="2012-07-11" version="1" precursor="true">MLNCIQITGCNTFLGPEAVILTMLLVRIPVSREKWDLGNCQSRFSLTAISVSRQVSSALRTEMLKQVQMIEYGVGMSNQRLQPFLSSCHSEMILLRISLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V7</accession>
    <name>I2F1V7_9BACT</name>
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    </gene>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
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                <person name="Bruce D."/>
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                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="entry name" value="6PGD_dom2"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="359" mass="39327" checksum="F4E7E8FEEB036004" modified="2012-07-11" version="1">MKIAVVGAGNGGQALSAVLAMRGHDVSLYNRSQKRISPIMTDRKIRVEGESSGKAKLRYVGTDMKKAVDGVEAIMVVVPAFAHAQIAAELADCVTEGQIIVLNPGRTGGALEFDKIFREKGAREKVVIAEAQTFVFASRISGPGMVRIFRIKNAVPVSVLPSKDNEAILPIINEIMPEFTLAKNVLYTSFNNIGAVFHPGAILMNAGWIETKHGDFQFYLEGISPSVARVLEELDKERCEVTSKLGVVAMGAREWLDYAYDVKGDDLYTAIHSNEGYRGIMAPISIENRYIMEDVPMSLVPMSCFGRKLGVETRIIDSVINIAGAVIGRDFWKEGRTLENLGIDRLSVEDLLKYVEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W3</accession>
    <name>I2F1W3_9BACT</name>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="63"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="398" mass="43562" checksum="3583AE387BC60E07" modified="2012-07-11" version="1" precursor="true">MRKRIVLLLTYTFITTITISMYRVVYNLYLREIGFSNHLIGNVTSAQLWGSAIIGLLTAVLADTIGKKKILFLSAIVVPVSGIALAFVVDPTLIIVLSFIKGGFTVTAFTVVMATMTSITKTGNRAKVFGLNFGINMASGVIGNFIGGAFGDLFGLQTTLIISMVAHLPAIIPVIRLEMTESRSKLKELFNFSGLQQDQRKVLTYYFISTATVGFGAGLFIHFGNLIFKDLFNMSATGIGIALSIAQLGTAAGSTLSHKLGKRFGALKFNLTMQLLVIPLMLSLVIVREPILFTILYAFRFVFMNITNPIMTSIIFSYVPDSKLSTVSGINGFLNNTVRAVAAMIFGFIVGTSISGYTELFLLSTAFYAANAFIIFLFYRDFKNEPRVLELYDSKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F206</accession>
    <name>I2F206_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730121.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0225"/>
    <dbReference type="EnsemblBacteria" id="AFK05959">
        <property type="protein sequence ID" value="AFK05959"/>
        <property type="gene ID" value="Theba_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0225"/>
    <dbReference type="HOGENOM" id="CLU_1775245_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="15795" checksum="4988FA65C594C26F" modified="2012-07-11" version="1" precursor="true">MKRLIFTILIITLVLLSGCVFKSNPAGFVEIAGTWALAGRVVYGSTDVSGTGTLYITRQEGSDFSGTGWYFLLSAPVEGTVSERPENYLVMHATVNYGGNERTVLFTGHVLEADDGVSVEDGEIFLDDLTKKIGTWTGEWTPPPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F235</accession>
    <name>I2F235_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491714.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0254"/>
    <dbReference type="EnsemblBacteria" id="AFK05988">
        <property type="protein sequence ID" value="AFK05988"/>
        <property type="gene ID" value="Theba_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0254"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473370_0_0_0"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="183" mass="21058" checksum="4E003C47EF15D788" modified="2012-07-11" version="1">MRGQETRERIMEAAIQVIAEETIEGLSTRKVSGIAEVNLAAIHYHHRSKEGMLIDLSRHILNNYVLPRIEPLIDQGKQPVEITRDLYAELLKLYSERPDIMVSLVYLWLHGMKNKRVREILINARADFYDRLERALGSSMSMRRASKVSHRLLSYIAGKIMEMAVDGEMPDEKEVDEIAKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F245</accession>
    <name>I2F245_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730156.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0265"/>
    <dbReference type="EnsemblBacteria" id="AFK05998">
        <property type="protein sequence ID" value="AFK05998"/>
        <property type="gene ID" value="Theba_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0265"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_1_0"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="31996" checksum="F65A3A3C86F506EF" modified="2012-07-11" version="1">MKLAEFSPFFNCKLKNFLDELHISKPFKDVVSYTPLAGGKRLRAYLIWELSRYTGFGEENALKAGIAVELFHSGSLIHDDLPAIDNDTIRRGLPSSHIKFGESKAILAGDFLMLFPGRVFSSLDLETRYIHPILELWQETSLKVVEGEFDDVFPEDESREQMERIHAAKTGALFGFCFAAPFIREKREKIDEMYKLGVRFGKLYQMMDDIKDVISTESELGKTPGKDGKQNKLTILSFESLEEAQIEVKESFHSILGEIDSFTDLKKEMRDIYYLIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F248</accession>
    <name>I2F248_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ORF">Theba_0268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730159.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0268"/>
    <dbReference type="EnsemblBacteria" id="AFK06001">
        <property type="protein sequence ID" value="AFK06001"/>
        <property type="gene ID" value="Theba_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0268"/>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_0_0"/>
    <dbReference type="OrthoDB" id="773697at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="56"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="404" mass="45601" checksum="940FB107A53C96CE" modified="2012-07-11" version="1" precursor="true">MNRFVVVRYGEIALKKGNRKLFEKVLVNNIKRQLGRSTVERIRGRIIVSVPSERLRSSIEIMSRTFGIQNFSVGTWTSYDLEDIYLTSVDLAKDEMKRGRKTFKVETRRLDKRFPLKSVELNPLVGERILEELPETSVDIHNPEFKIEIEIRDEGVLISSGKTTASGGLPVGVSGRALLLLSGGIDSPVAGWLAQKRGLDLDAIHFSSPPYTGERSFDKVLSLAKTLSIYNGGREFRLYSMHFTDAQIAVHKHVEERYSLVCQRRLMMKIASKIAEAQRIIAIVTGENLGQVASQTLENLRVIEEQTELIVLRPLLSYDKIETIELAKQIGTFETSILPYEDCCTVFVPSNPVTKARLFDINRVEAGLDLECLAKDIIEKSKMYRIKNGDILEVKSIEIPEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F250</accession>
    <name>I2F250_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730161.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0270"/>
    <dbReference type="EnsemblBacteria" id="AFK06003">
        <property type="protein sequence ID" value="AFK06003"/>
        <property type="gene ID" value="Theba_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0270"/>
    <dbReference type="eggNOG" id="ENOG502ZR1T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641739_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="161" mass="18027" checksum="09EDF78539B8871E" modified="2012-07-11" version="1" precursor="true">MIYRIIFSLFLLFIMPFLNYSIMLSAIVVSLVLIGVILGSKTERVARIQNLTLTLFYVVILFGYFQDTAGMVYRSEVVILAVAQGVSGFYGLFHHRRSLSVVLSLGYWILVGTALSRIAWMRLGSGGLILGIALIALVAFQDIRRIYKPLVRSPFEQDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F256</accession>
    <name>I2F256_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0277"/>
    <dbReference type="EnsemblBacteria" id="AFK06009">
        <property type="protein sequence ID" value="AFK06009"/>
        <property type="gene ID" value="Theba_0277"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0277"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="269" mass="29382" checksum="743B653101EA3C53" modified="2012-07-11" version="1">MNPKEMAERMETIRDNVKSIKNKILVMSGKGGVGKTTVAVNLALALADEGFKTGLMDIDLHGPNVARMVGLKKQPEVVEGQIFPPEALPNLKVISISSFVEEDAPVIWRGPMKTTAIYQFLGDVMWGELDFLVIDSPPGTGDEPLTVLQTLTDLVAVVVTTPQAVAVQDVKRAINLVKTMHRDILGIVENMSYLRCPHCGEVIRLFGEGGGKELENLFNIPLIGSLPFDPALVGFSDTGKSIVTNMRGSELETAYRETVREIVKRVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C7</accession>
    <name>I2F2C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bacterial cell division membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730215.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0351"/>
    <dbReference type="EnsemblBacteria" id="AFK06080">
        <property type="protein sequence ID" value="AFK06080"/>
        <property type="gene ID" value="Theba_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0351"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_1_0"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="362" mass="40593" checksum="010732D2CC415BF4" modified="2012-07-11" version="1" precursor="true">MKRRVEFLLPIIMVSLMIFGLVVLYSATFGESEAYLFGRQLVWVLLSCAVFVFTAYVVKKELWKSLSFPFIILSTVSLAAVLYLDSGEASRRWIDLGIASFQPSELAKFSLIIFLGNVYSRDAKHRFGLFSLGIFFTLVFVGLIYLEPDLGTTIIVLIIWYFMTLISKRYDRLMIAITVLIAFLAPIVFMYGLKPYQRDRLLSFLHPEEYASGAAYNTIQAIRAIGSGGLKGTGYLQGTMNRLGYVPADHTDFIFSVLGEELGFIGAVSLLVLYLLLLWRVWSITRKTGSEFGRIVLSGIFAVFAFHVVENVGMNLGLLPVTGIPLPFVSYGGSSSMLFALQLGIVHSYSVKEIEYDKEQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C9</accession>
    <name>I2F2C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">Theba_0353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730217.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0353"/>
    <dbReference type="EnsemblBacteria" id="AFK06082">
        <property type="protein sequence ID" value="AFK06082"/>
        <property type="gene ID" value="Theba_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0353"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_0_1_0"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="67"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="404" mass="43947" checksum="2C513CD5E41A7F4C" modified="2012-07-11" version="1">MVKADLAILNIGQIASPKKAGPIRGKEMSSLETRHNMHIAIEGGKISYVGRENVEAREYIDGTGLVAIPGFVDSHTHIPFVGSRSKEFLMRLSGKSYMEIMKTGGGIRSTVKEVRKASASELVAESLRHLDRMLSLGVTTIEGKSGYGLDKENELKQLKVLKTLDSIHPVDLVPTFLGAHAVAEEYESSDSFLYSMAEMLDDVSEYTDTVDIFCENGVFSENQSRWYLKRAKEKGFKLKLHADELSASGGGRLAVELGALSADHLISADDGTLELLSNSNTVATILPGTSFFLNEAFAKGRELVDRGAIVALASDFNPGSCNIYDPFFIIFLAVSRCGLSVEEAIIAYTVNGAKALCLEDRKGRIEAGFDADLVLIKAGDYSEIVYNFSRNIVSGVIKSGKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E8</accession>
    <name>I2F2E8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="5" type="ORF">Theba_0372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730228.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0372"/>
    <dbReference type="EnsemblBacteria" id="AFK06101">
        <property type="protein sequence ID" value="AFK06101"/>
        <property type="gene ID" value="Theba_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0372"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_5_1_0"/>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="145" mass="17048" checksum="34CECE70AA8AD76A" modified="2012-07-11" version="1">MLSDPMKDAVRYIRYRMRSRKEIEDQLLKKGYSQEEVDEVIEKLEEQKLVDDRVFARLYVSDGLNVHHKGPFRIRQELFKLGILEEIISDSIEKELENCDLKEIAKIAIGSAERTDADKIRRKLYRKGFSSSLIDEVIDEIDEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F0</accession>
    <name>I2F2F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="8" type="ORF">Theba_0375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730229.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0375"/>
    <dbReference type="EnsemblBacteria" id="AFK06103">
        <property type="protein sequence ID" value="AFK06103"/>
        <property type="gene ID" value="Theba_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0375"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_0"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="463" mass="53414" checksum="022BC40C944037AF" modified="2012-07-11" version="1">MDNFELEVLRFVKEWDLVREGQRILVAVSGGKDSMALLNVLNNLKSTLKIELFAANLNHGLREEGPQEEARMIEQFCEDRFIDFFHEKRDVREYMRTKKGESIESAAREVRYGFLRDVKSMIGADRIALGHNRDDLVENTLLRLVKGTGMKGVIGLRPSNGDLIRPLLFSDMQRIIDYVTINKVTFMEDETNAEDGFERNFLRLRVIPELRKINPALNKAIWRFFENIYDGYSLIDSRVETLMSRFGKADGIYFAKLSELREIEKPLILELVRKIVSMMSFDNYPPSRQRALAFFDLFSKDEGRWTVEFKENLKASRIGKYVFFYRGTLEFHGHEKSFIESIPFVCEAEGWQIKVESKAGISSENYGEFDGAFKSICSDSRIIFPLSIRGMNNKDKIIPFGMKREKKVVDILSDKGLKGFSSMIMVLENAFGEILWIPGVVTSELCRVGPSSRNNVVFSLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G4</accession>
    <name>I2F2G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730237.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0389"/>
    <dbReference type="EnsemblBacteria" id="AFK06117">
        <property type="protein sequence ID" value="AFK06117"/>
        <property type="gene ID" value="Theba_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0389"/>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882358_0_0_0"/>
    <dbReference type="OrthoDB" id="1414332at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="219"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="36920" checksum="CD2A2B294B27F2E1" modified="2012-07-11" version="1">MRSIFRDFTYDYFGILSYPKERWFDFWTSYREKHPRVLEEYMFKNNLDEEELSLSLDKLERREIDRLSHYWEIQGPIEKSRVLKELGKMSPQLHLEREDFVIHILGALGRQQHLIVPTSRGNVVMIDLLFCWKEGSIKDFSSVILAALKDFLEYSRVNVRHTMDSGKRSERFDLILDVIEREIKGRSFKEKMAMISKLLDKYVDYYNWTGFYLVNEERSLVLGPYVGEPTEHVKIAFGSGICGQAAETKKVFLVPDVSKENNYLSCSSKTKAEIVLPLIVDGKVIGELDIDSHFQNSFDRLDEEFLEKVCGLLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G7</accession>
    <name>I2F2G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730239.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0392"/>
    <dbReference type="EnsemblBacteria" id="AFK06120">
        <property type="protein sequence ID" value="AFK06120"/>
        <property type="gene ID" value="Theba_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0392"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908531_0_0_0"/>
    <dbReference type="OrthoDB" id="1902407at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="306" mass="35352" checksum="891FDBCF346EBDAB" modified="2012-07-11" version="1" precursor="true">MIRLSPYIFFVGGFLTYASIFFSSATVSMTMSVIGMTISLYIWYILAWNRDRHLATMKKKGYVKPQNCAEQKIAGNSRIWVILYSASYLTMNFAGLYIIRAIIENIDMSLDTMSMEELITLLGSGYVLSSWLFFITGIASIFLYGKLITMLYNDEMKIQSLESKQRNIPVLILKPLSVVIMVIFTLITYGLFSWFMRYRLAAIQRFHNQIEKKLDELEESFKDKAKNIKKEKEEQPSKSISEEILEKYSRSLASSEESDDRKLIIASLFKDLGNLKSDQARSLLNDLLSKQLLTENEFNRLTRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L4</accession>
    <name>I2F2L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730282.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0440"/>
    <dbReference type="EnsemblBacteria" id="AFK06167">
        <property type="protein sequence ID" value="AFK06167"/>
        <property type="gene ID" value="Theba_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0440"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_0"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="399" mass="44625" checksum="5E11D9B286520971" modified="2012-07-11" version="1" precursor="true">MKISQRGIFMPSSPIRKLVPFAQKAKDRGVKVYHLNIGQPDIQTPKVFFDYVNKLSDSVVSYSPSDGIKELKEAFSKYFRSWEIDVSADELLVTSGGSEAILFALAAVADPGDEIMLIEPFYANYIGFANMLGLKVRAATSRISNGYRLPDDEELSKALTARTKAILFSNPSNPTGVVYTEDELRRLIEFARRNDLYVICDEVYREMVFDGIKPSSIMTIDSGQDIIIVDSISKRFSSCGARIGCVATKNNEVYRTMMKFAQARLSPPTIAQLGTIGLLTLGKEYTDSVRREYELRRDVVFEELSKIDGIEMQKPSGAFYISVKLPVENAEEFVTWMLTDFSYDGSTVMVAPLEGFYSSEGVGRKEVRIAYVLSSEKMKIAIEVLALGLKEFNRSFATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L8</accession>
    <name>I2F2L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase possibly involved in lipopolysaccharide synthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730286.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0444"/>
    <dbReference type="EnsemblBacteria" id="AFK06171">
        <property type="protein sequence ID" value="AFK06171"/>
        <property type="gene ID" value="Theba_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0444"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914681_0_0_0"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="124"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="304" mass="34422" checksum="A9C3C6E64EBF12B4" modified="2012-07-11" version="1" precursor="true">MMNSLFYLIDLLLALPLLMNGLGAFIAACCTSVLISFSMRGYEGITISDKEKQMASTLGSAVMSCFVFPVFLPVSPFVALPALGATVVRNFILYKRVKSQFKEESFMLTSNDPIEPKVVYDSFKRLLDVGIGVIMLVLFSPIIVIVSLISLLMEGRPIFICQTRIGKDCKQFGMYKFRTFDTKGNKETITKLGKFLRPLRLDELPQIINIIKGDMSLVGPRPELPSFHKLGMDNIVDYSSRLLVKPGLTGWAQINYKYTTTLEEYRIKTAFDLYYVKNRSFILDIKCLFKTPFAVFLTLLKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P7</accession>
    <name>I2F2P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type proline/glycine betaine transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0474"/>
    <dbReference type="EnsemblBacteria" id="AFK06200">
        <property type="protein sequence ID" value="AFK06200"/>
        <property type="gene ID" value="Theba_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0474"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="213" mass="22420" checksum="88AC28F686BA3A14" modified="2012-07-11" version="1" precursor="true">MEVLEYMFENSGYIMERLLEHIFIFLTSWSMAVVAGVAIAIFVTRPGHRKAGKLVLSITGATQAVPSIAVIALVFLFMGIGAAPAVVALFLYSLVPVVFNTASGLMNVSMMMKEAAKGMGMTNRQILWKVEMPVTVPTMLSGIRSSATINIGTAAIAASIGAGGLGEIIFTGLRMTRGPMIIAGAIPVTILAIAVDIILGFSEKALTSKGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R5</accession>
    <name>I2F2R5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730326.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0492"/>
    <dbReference type="EnsemblBacteria" id="AFK06218">
        <property type="protein sequence ID" value="AFK06218"/>
        <property type="gene ID" value="Theba_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0492"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658495" description="Dipeptidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="518" mass="58936" checksum="B0349269447D827A" modified="2012-07-11" version="1" precursor="true">MKLKLKAFLVLVILLVFLSSTALTCTILAVGKDASVDGSTIVTHNDDSSSADFRLWIIPAIDWPEGSMRDIVIDSHNYIDYGDFPFVDVGDKGVVVGQIPQVEHTYQYFHSRYSFIKEMGVAMGESTAGVRRELREARGWIDCWTAQDIALERASTAREAVRIMGDLVEQYGWYGSGEIMNVTDGDEVWIAEFYGRDLWVAVRMPDDCVFVGANTMRIRDVDFEDTENVMYSPNLISYAVEQGWYDPNSGEPFRPADVYAPRSSGNIREWRAFSLMAPSMGYEYLDVHYPLWIKPDKKLSVWDIFTISGDWYEGTEFDLTKGIGAGPFGDPFASYRVGGRQRPIGIYLSCYVQISQIKNWLPPVIGSVVWFGYGGGGTQYHTPLWPAMSELPEFYQVGSRYEDFRRDSGWWTSTYVQEMTRLRFKDAIVDLRNFRDPKMQAVYQTVPKIQELATELYETDKDAALAIISDYAYNTAVAWQADWLKFGDYLVGKYCADRINFGTGLPKEWGELLDSLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S2</accession>
    <name>I2F2S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730332.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0499"/>
    <dbReference type="EnsemblBacteria" id="AFK06225">
        <property type="protein sequence ID" value="AFK06225"/>
        <property type="gene ID" value="Theba_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0499"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862779_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="322" mass="35856" checksum="B3850C2500C885EC" modified="2012-07-11" version="1" precursor="true">MRRVILLGIVSFFSSISLASGFYIGSGFNGLVEVIAGNQEWNMRVIPVTSLSSGGIVAGKLIFNVLRDKGFAVIPALQPEGYRVVDTFHCEAIEVNIERLEVFVADGTHGVEVFKFYGSSFYKHIQTMPLKGWVNSLAYLDDYLLVGSELDGLFVIRRGENGFELIDHIYPRYVSDLEEGVIVNAIAAWEDSFYVAAGERGVITFEIGDSAFVKKAEIKVGYAMDVSVSDGDLFVVDSRVDEILVFDTDDLSLKERHVVNGKLREAVPIVDWQNHNKLLVCRLDDSVAVIDRNTSQEIFSLKGSFFGLVEARYFLGHPFLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U7</accession>
    <name>I2F2U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="2" type="ORF">Theba_0527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730357.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0527"/>
    <dbReference type="EnsemblBacteria" id="AFK06250">
        <property type="protein sequence ID" value="AFK06250"/>
        <property type="gene ID" value="Theba_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0527"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067790_0_0_0"/>
    <dbReference type="OrthoDB" id="896350at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="229" mass="26520" checksum="BE7E662E73831B9C" modified="2012-07-11" version="1">MKIDVLDRGFVELVDKMGDDYSAVQAARTSYGKGLTNKERDDRLIDYLMKNGHQSPFEHIIFKFHLKLPIFVMRQLVRHRIASINERSGRYTEFSEEWYLPSVIRIPDKDNRQGSIVCKDKEMNERAISIISEAYENAYAAYKRLIEMGVAKEMARIVLPTSMYTEAYWTVNARSVMNFLNQRADSHAQAEIQEYAIAIAEIFKTGCPVTFDAFIRHSYTGDLLNREAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F320</accession>
    <name>I2F320_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492248.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0604"/>
    <dbReference type="EnsemblBacteria" id="AFK06323">
        <property type="protein sequence ID" value="AFK06323"/>
        <property type="gene ID" value="Theba_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0604"/>
    <dbReference type="eggNOG" id="COG1553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151801_1_0_0"/>
    <dbReference type="OrthoDB" id="1997912at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13162" checksum="1879CCFFF2CD1F57" modified="2012-07-11" version="1">MRITIQVFAPPYSYEDLDSAIKIAEAGLNKGHEVTIFLFADSILSINSKVKPIRVDRDIPRKLESMIKEKGLKVEICGICMDYRGVTKDMIIEGSNPSGLPELASLIFNSDRFVNLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F322</accession>
    <name>I2F322_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur relay protein TusB/DsrH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730403.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0606"/>
    <dbReference type="EnsemblBacteria" id="AFK06325">
        <property type="protein sequence ID" value="AFK06325"/>
        <property type="gene ID" value="Theba_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0606"/>
    <dbReference type="eggNOG" id="COG2168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166087_1_0_0"/>
    <dbReference type="OrthoDB" id="1995110at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007215">
        <property type="entry name" value="Sulphur_relay_TusB/DsrH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37526">
        <property type="entry name" value="PTHR37526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04077">
        <property type="entry name" value="DsrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03011">
        <property type="entry name" value="sulf_tusB_dsrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="87" mass="9543" checksum="56E81B15962405CB" modified="2012-07-11" version="1">MYLIVVKNGPNNSAERVKISASKEGDSVVLIQDGIFWALNDIETEAKCFAIKDDVEARGYTADDVTVPLISYDGFIDIIEKCDKSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F327</accession>
    <name>I2F327_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730408.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0611"/>
    <dbReference type="EnsemblBacteria" id="AFK06330">
        <property type="protein sequence ID" value="AFK06330"/>
        <property type="gene ID" value="Theba_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0611"/>
    <dbReference type="HOGENOM" id="CLU_1967949_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="127" mass="15045" checksum="F45DFF6F545A605B" modified="2012-07-11" version="1">MKKTDLDLERLSSTSWKWLNSEEAEVSGGENSRQPQAMYFFTDEKNRSFCRRYNREVNFKRDVEDIGLCDKCGMRFRTYRAAQICVFAPAEAYYTIDTRDEAKEIEEFPDKDFAERGVSDFESKSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F353</accession>
    <name>I2F353_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsgA</name>
        <name evidence="10" type="ORF">Theba_0638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730433.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0638"/>
    <dbReference type="EnsemblBacteria" id="AFK06356">
        <property type="protein sequence ID" value="AFK06356"/>
        <property type="gene ID" value="Theba_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0638"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_1_0"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="79"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="88"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="35071" checksum="1D3D4C551AE4DB00" modified="2012-07-11" version="1">MWSVKAEKKGIVLERRKGVVVRFGSRNMEVVDAETGGRLICTMPGRFRLQGIRPIVGDRVEYALSGDGQGRIESILPRKTELLRPRISNIEQILLVLSLKEPAVQNLITDRFLVLAEYAKLPVTIVVNKIDLINNEELDRFSDVYGEHYEICPVSSKNRINLDRLREVLKGKISVMAGMSGVGKSSLLNSLNPGLKLRVSEISRGLERGRHTTSYVELLQFEFGGLIADTPGFANLELPVIAPENLDKCFPEISQEQGMCAFSDCVHVDEPGCYVKELVEAGSIHRSRYESYLIMYNELKEREQEKGGRKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A4</accession>
    <name>I2F3A4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">Theba_0690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730470.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0690"/>
    <dbReference type="EnsemblBacteria" id="AFK06407">
        <property type="protein sequence ID" value="AFK06407"/>
        <property type="gene ID" value="Theba_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0690"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_0"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="61" mass="7233" checksum="C8D6205BD17E6ABB" modified="2012-07-11" version="1">MAKKSIVEKWKREPKFKVRKYNRCNLCGRPRAVYREFGLCRVCFRQLASEGKLPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D6</accession>
    <name>I2F3D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Positive regulator of sigma E activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0722"/>
    <dbReference type="EnsemblBacteria" id="AFK06439">
        <property type="protein sequence ID" value="AFK06439"/>
        <property type="gene ID" value="Theba_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0722"/>
    <dbReference type="eggNOG" id="COG3086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124911_1_0_0"/>
    <dbReference type="OrthoDB" id="2057471at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026268">
        <property type="entry name" value="RseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007359">
        <property type="entry name" value="SigmaE_reg_RseC_MucC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35867">
        <property type="entry name" value="PTHR35867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004923">
        <property type="entry name" value="RseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="144" mass="15757" checksum="C1AE332F97A6D317" modified="2012-07-11" version="1">MRELAIVKELKGDVVLLEKARTEACSTCGSRSSCSISSSDKKITIRALHNGVEVNPGDTVEIEMSNMSATRVSMIVYGIPLAVFLVTLIVMNMVLKSEGLALVVAFASIAVVYALIALYDRKNREKLMPKIVRKVELPDGFIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D7</accession>
    <name>I2F3D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="10" type="ORF">Theba_0723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730498.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0723"/>
    <dbReference type="EnsemblBacteria" id="AFK06440">
        <property type="protein sequence ID" value="AFK06440"/>
        <property type="gene ID" value="Theba_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0723"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_0"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="708"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="511"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="331"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="768" mass="85987" checksum="ED14669B7D531A2E" modified="2012-07-11" version="1">MDSLFDDSIRLLEFDSVLADIAQKATSKYGKERVKSLRPKAEDAEILYTRSSEFNEILLREGEPPFTVFHDLSDYITKVKRGFSLGGEELFRSAVTMDNVCRLREFFDRVSPDFPAVYEVAALLSCERGFIGEVRKKISEDGQIKDNASPLLKEIRNELKNLNRNLRGRLDSIMNRYKDSLTDSLILTREGRYVLPLSASKKNEHQGVIHGASGSGATVYFEPQELITLNDSMRILLSREEEEIRRILRELTTLFFSTFERLEPSLEALGVLDGLYAACRYSKSRRGVFIEPSPSRHFLLKDARHPLIDDEVVVPITFTMEEGVNGVFITGPNTGGKTVAMKTIGLSVLLMLCGLPVLADGLSKIPLFSRLFADIGDEQSIEQSLSTFSSHISRIIRIIRNADENSLVLLDELGAGTDPVEGSALSIAIIERLLERSRLILTTHLTPIKLYAMERPDVVNASVEFDISTLKPTYRLLMGIPGSSNALEVSSRLGLPQEIVDRARSYIDSEARDLEAVIGKLHRERSLLEEERRDLGKTKRELEGRTKEFEEKLSMIKEKRYREVSKEIDELEKKLESIIKDVEMAISLSRAPGEREKVEAVKRLNNLRREVRNFGASYPEKTDSQIPEVGDKVKLLESGAEGIVSEIDGDRVVIDSGKITLKVPLSRVRLVGKPVVESEMSSFELDSGNSSQEIDIRGNITEDVPILIDDFLQMLKASGKKQGYIIHGKGTGKLAEGVWAYLRRSKEVKSFRIGTPSEGGSGVTVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E2</accession>
    <name>I2F3E2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein Theba_0728</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730503.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0728"/>
    <dbReference type="EnsemblBacteria" id="AFK06445">
        <property type="protein sequence ID" value="AFK06445"/>
        <property type="gene ID" value="Theba_0728"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0728"/>
    <dbReference type="eggNOG" id="COG2052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165326_0_0_0"/>
    <dbReference type="OrthoDB" id="1786332at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="99" mass="11004" checksum="EEE3EDBF1ACBCDA9" modified="2012-07-11" version="1">MYGLINVGFGNVIIGDRVIAIVNPESAPLKRLKEVAKDEGKLIDATYGRKTRAIVITDSNHIILSAIQPETIASRFMQTFSDIEKLLEDIRVSGQNFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H6</accession>
    <name>I2F3H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ORF">Theba_0765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730533.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0765"/>
    <dbReference type="EnsemblBacteria" id="AFK06479">
        <property type="protein sequence ID" value="AFK06479"/>
        <property type="gene ID" value="Theba_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0765"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_0"/>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="190" mass="21518" checksum="16D40048CBE56DB9" modified="2012-07-11" version="1">MTVKSTELVRTVFSKGEYPPPLRREIAFAGRSNVGKSSLLNSLFGRKLAKTSSTPGKTRSINFYGVNREIYFVDLPGYGYAKASMSEREKWKKLIIDYFESREELSLVVVLVDIRHPLQPADIQMLEWVTYYTIPFILVLTKADKLSRNQQIIAEKSIKDELASLGVYPPVFVVSAVKKQGIEELLIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J4</accession>
    <name>I2F3J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730551.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0783"/>
    <dbReference type="EnsemblBacteria" id="AFK06497">
        <property type="protein sequence ID" value="AFK06497"/>
        <property type="gene ID" value="Theba_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0783"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_1_0"/>
    <dbReference type="OrthoDB" id="1068600at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="30780" checksum="D9FD5812A506406F" modified="2012-07-11" version="1">MIYLGTSGYSFPDWVGTAYPAEISSSQMLRYYHSVWRFNSVELNFTYYRMPTYKTVTGMIRKIPGEMIFAVKAPGRVTHEIWKNGLNELEEISDEFYNALFPMKEEGRLGPLLFQFPWSFKNNKENMSYIKAVAKTFSSDKNLLAFEFRHESWAAEEVFETIDRLGVVPVTVDEPSFGGLFPYLPRSGSRGAYFRFHGRNPDWFNSKGSERYNYDYPKTDLRRFALDVLEFHKHDLPVYVFFNNCYMGRAVHNALLMRDILGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P5</accession>
    <name>I2F3P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730589.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0834"/>
    <dbReference type="EnsemblBacteria" id="AFK06548">
        <property type="protein sequence ID" value="AFK06548"/>
        <property type="gene ID" value="Theba_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0834"/>
    <dbReference type="eggNOG" id="ENOG5031XAC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1703140_0_0_0"/>
    <dbReference type="OrthoDB" id="1786129at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="152" mass="17262" checksum="4EE33FF2FECBACB5" modified="2012-07-11" version="1">MKQTPDFDRIQENMRAGNITGPGFLGDDDRNLVDIISEDQITVKELGLTNEIIADKLEMLMKEGERGFGSPVKVDDRFVVIVEESRGYIPCPFRHGHLSKKVNVNVRNIALKEEIDYSPISIHLIREHGFFQGKGSPYRLDPTRIAKILELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P8</accession>
    <name>I2F3P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloendopeptidase-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730592.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0837"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="AFK06551">
        <property type="protein sequence ID" value="AFK06551"/>
        <property type="gene ID" value="Theba_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0837"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_3_0"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="30973" checksum="01D487B450A96E28" modified="2012-07-11" version="1" precursor="true">MNRRVILLFLFMSSLLMTRSFAYFLVTYVVRAGDSIHTISRDLDVSISTIIDFNSLKNPNSIKAGDTLRIPQPDGLIYEVQSGDTFDYIAKLFFSPVDELIAANNLKPDSVINPGQRIFIPMSLVNLYQYIPQSSPFRWPIYGVISSDYGWRTHPVTGQPSFHSGLDIAAPEGTPIFAGSGGTVVFAGVNGGYGNMVEIQHDNGYLTRYGHMSKISVYVGQRVDAGSLIGRVGSTGVSTGPHVHFEVRDPRANTMNPLSMLPTRDLMYVIRREDDGTAAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S7</accession>
    <name>I2F3S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730618.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0870"/>
    <dbReference type="EnsemblBacteria" id="AFK06580">
        <property type="protein sequence ID" value="AFK06580"/>
        <property type="gene ID" value="Theba_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0870"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825860_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="333" mass="36443" checksum="B5DDA26D12028258" modified="2012-07-11" version="1">MKCLVFGENLSGWNTGSSFILADVSDPAKISVIARAKASGNCMAFLVDSGRLYCLEREFFEVFDITDIENIRMLKRIEGYCGGYILFDKMKELLYLSNWRRGIAILDVSKRDDPIPLGSADCDCVDLHPVGNDGPYGMSSGLCLRGNFLFGATMDYVTSRNLGALYMYDVSDPSNPKKVTKIPTPDFRAHGMDSKGNYVFAVGAHGVLSFDISIPEDPMTVGELKTGNHFLVSARLADDFLFAVGVIHSSVEHNGILDVVDISNPLHPRLIGEIVLPLSFFGDSITIDNEIAYVVCDSGVAIVDIGRPESPRLLSARNAPEGKWNSGIHIYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T4</accession>
    <name>I2F3T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730625.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0877"/>
    <dbReference type="EnsemblBacteria" id="AFK06587">
        <property type="protein sequence ID" value="AFK06587"/>
        <property type="gene ID" value="Theba_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0877"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_0"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="435" mass="46665" checksum="580C88352279C555" modified="2012-07-11" version="1" precursor="true">MKKGKATFVLFLLLFMMVFLNADQMVMSPNMGEIEAEFGITKADIGLIQGSFTIVGALISLLWGFFADKYNRKLLLLLSVLVGEIPCFLSAFVQTFPQLFVARALTGIGVGALFPVVFSYAGDAFKESQRAKVNSFLSTAISLGAIVGMVIAGFTGASLGWRIPFIIVSLPNILLALLFFLFAEEPKRGAAEVAVGDLVDKGVNYIGKVRLSDYKNLFKVKTNLILFIQGILGTIPWGAIPYYLVNFFETSKNLSKESATMIFIFFGVGNVLGIFFGGLIGGLLYKKKPSYMPLFSGIMTIIGTFVALLALNFPPVEGAGGFVMLGALGMVAAASASMTGPNMKTMLMNVNAPENRGRIFSIFNLTDSLGTGFGQFFAGTLATAVGSLGVAMNVSALFWLPCGLVLLTAALVFPKDIASLNKKMKEAALTMEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y0</accession>
    <name>I2F3Y0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">surE</name>
        <name evidence="7" type="ORF">Theba_0927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730656.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0927"/>
    <dbReference type="EnsemblBacteria" id="AFK06633">
        <property type="protein sequence ID" value="AFK06633"/>
        <property type="gene ID" value="Theba_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0927"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_0_0"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="272" mass="30440" checksum="8A236E87E755B81B" modified="2012-07-11" version="1">MRILLTNDDGIESTGIRSLAKKLSAAHEVTIIAPESNRSGVSHSITWLTPVKIRERSTVENVSSFCTSGTPADCVVAASVIKGLGNFDLVVSGINYGQNLGVDVRYSGTLSAALEARIHGIPAMAVSIASEENPDFLAAVDFSENFVREYDWKKLPKHTVLNVNVPAVPRNRIKGINCTRPGGLLKRRWFEKKVNEWGEEEFWMKKEILYDSHEEDLDYVSIDRGFISVSPIDFFGSCEESFRLSLEEDLKIFEARWLNKGNEKFSMASFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z0</accession>
    <name>I2F3Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_0937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730665.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0937"/>
    <dbReference type="EnsemblBacteria" id="AFK06643">
        <property type="protein sequence ID" value="AFK06643"/>
        <property type="gene ID" value="Theba_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0937"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_4_3_0"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="359" mass="38836" checksum="8C10F9D0CEAE54F3" modified="2012-07-11" version="1">MKLATEIAGIHLENPLMPASGPLTGDQRKMRAIEAMGVGAMVTKTISTVAAKVPRPCIIAERDFVINTELWSEFSPEKWLNEFLPDYRKESALPLIVSLGYSPEDLRKLVPRFAKFADAFELSTHYVADDPSLIRELISAVKAGTEKPVFLKFDPSVPDPAEMARVVQESGGDGIVAINSLGPVYPMDRRVNRSYLGSRDGFGWISGPVIRRLSLSSVRRIREGCTLPIIGVGGIVSADDVVDFLCAGASAVQMLSGALIRGKGIFKRILESLPSALEKRGFKSVEEAVGSAKDQKESFTVRNPVIDHDKCTRCGLCVEVCPYFALSLQEKVEVDSAECFGCGLCESICPVAAIGGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F400</accession>
    <name>I2F400_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sn-glycerol-3-phosphate transport system permease protein UgpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730674.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0947"/>
    <dbReference type="EnsemblBacteria" id="AFK06653">
        <property type="protein sequence ID" value="AFK06653"/>
        <property type="gene ID" value="Theba_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0947"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015794">
        <property type="term" value="P:glycerol-3-phosphate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030165">
        <property type="entry name" value="UgpE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43744:SF8">
        <property type="entry name" value="PTHR43744:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="70"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="276" mass="31466" checksum="75FB34B68BBD3B34" modified="2012-07-11" version="1" precursor="true">MKQRKSSIFLSYLFLTIALVVIMFPIYYAFTMSTFDEKEAYSFPPKFIPSIHAVDNFATAWKTVNMGRLIFNSAFISITVALAKIFLSMLAAFAFTYFGNFKGKYFFFAVILITHMLPLPIRIVPTYELMRTFGWVNTYRALTIPFFASATGTLLFRQLFMTVPSSLSDAARIDGAGPMRFLFNVLIPLSKTNVGALFLIEFTYMWNEYLWPMIVTNSNNMRVVQIGIKMLLASEAQAAEWNIIMAGAIIAMVPPLIMLLLFQKTFMEGFSLKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F409</accession>
    <name>I2F409_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protease subunit, stomatin/prohibitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730683.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0956"/>
    <dbReference type="EnsemblBacteria" id="AFK06662">
        <property type="protein sequence ID" value="AFK06662"/>
        <property type="gene ID" value="Theba_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0956"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_0"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="34695" checksum="537159AE71808591" modified="2012-07-11" version="1" precursor="true">MVFWLILAAVIFIIAASGIKIIRPFEKGLVERLGKYRRDANPGLQFIIPFIERMVKVDLRETVIDVPPQEVITKDNVVVTVDAIIYYQITDAFRVVYNVSNFEIAAIKLAQTNLRNVIGEMELDQTLTSRERINVTLREVLDEATDKWGVKVTRVEIKKIDPPQDIMDAMSKQMKAERTKRAVILEAEGYKQSEITKAEGDKMSAILQAEGQSESIKRVAEANKFKLIAEAEGQANATINVFKAIHEGDPTKDVIAIRYLDALKQIADGKANKVFLPFESSAMLSSLGSMAEIFKDGKDSSSVNEKESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F416</accession>
    <name>I2F416_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic component of amino acid ABC-type transporter/signal transduction system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730690.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0963"/>
    <dbReference type="EnsemblBacteria" id="AFK06669">
        <property type="protein sequence ID" value="AFK06669"/>
        <property type="gene ID" value="Theba_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0963"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_0"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="29"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="5">
        <location>
            <begin position="29"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="255" mass="28961" checksum="562666AD0155EF66" modified="2012-07-11" version="1" precursor="true">MKKLLLVLVLLCMTLAFGSLIDDVKQRGVLRVGQDAGYMPLYGTNPDGDRIGLEVDILKKMAEILDVKLEFVVVNWDGIIPALVSNKFDIIWSAMTITPERALRVNFTDPYLTVGQIILYNTNKYELPPTEEDLNDPDVKIAVQLGSTGAEAANRLLSEAQIFMFETIDEAAFQVASGRADAMIFDSIYARFMAKKYDQLEVTEDLLTREDFGVAIPKGDFETLQWMNTFIQWIKTTGTLQELQDYWFVEYEPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F424</accession>
    <name>I2F424_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492701.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0971"/>
    <dbReference type="EnsemblBacteria" id="AFK06677">
        <property type="protein sequence ID" value="AFK06677"/>
        <property type="gene ID" value="Theba_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0971"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="32619" checksum="6531259F3DD76F88" modified="2012-07-11" version="1" precursor="true">MALRKAKFRHFSYFILPALLLLVIFVLYPTFNTIFLSFVDSEGNLSLSNYREVFSSRDILDPRGLERGFPFGSLIHNLMWIAIHLPLTTLVGLFLAILLRDVKGGGIVKSIIFLGMVMPMIVGGIMIRFMFEENVGVVNLVLQTLGLEGKTWTAYPETALFALIFGSVWLWTGFSMILYSAGLETIPNTYYEAAQIDGASKFKMLLKITIPLLKPITVVVLTMTLLWELKVFDIVYIATMGGPGGSSNVLALQMYLYGFREWDFGKSAVVAVLITASTLLAAIPMMKSAGDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F471</accession>
    <name>I2F471_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730734.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1019"/>
    <dbReference type="EnsemblBacteria" id="AFK06724">
        <property type="protein sequence ID" value="AFK06724"/>
        <property type="gene ID" value="Theba_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1019"/>
    <dbReference type="eggNOG" id="COG1528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065681_1_2_0"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="161" mass="18919" checksum="6148498359011735" modified="2012-07-11" version="1">MITARMEKEINNQIKAEFESAFIYMSMAAWSHKNGYFGAENFMWKQAKEEEEHAMKFIQYLKDVDATAEIPGIEKPNGEYESLLDVFEKGLEHEKYITSRIHNLVKISEEEGDYATNDFIQWYVTEQVEEERNFRDVVKRLKMVGNQANGIFMIDSQLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A6</accession>
    <name>I2F4A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">Theba_1054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730761.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1054"/>
    <dbReference type="EnsemblBacteria" id="AFK06759">
        <property type="protein sequence ID" value="AFK06759"/>
        <property type="gene ID" value="Theba_1054"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1054"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_3_0"/>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="31376" checksum="99F30C906F4AB48A" modified="2012-07-11" version="1">MNLNLTKSDKIFLGVISGGYIAVLIYMVVTDYKFQLEGVGQRWIYQLPFGEGPLSRVNPLTIIMTWVVMGLIIFMVTRVKVFKIIPGKKQSLLESLLEYVYDLVKDSVTRKEYVRPIFDIAASLFLFILVSNIIGSFPGINAFPTENGGVTFTILADTWYAPTSDLNMNLMLALFVFVMSHVYAIRVKGLKSWVKSFFEPIWWMFPINIIGEIAKPISHALRLFGNIMGGAILVLILGYLVKYFVLPAALWGIFGLFFGAIQALIFTILAIAYISSLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G4</accession>
    <name>I2F4G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_1112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730813.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1112"/>
    <dbReference type="EnsemblBacteria" id="AFK06817">
        <property type="protein sequence ID" value="AFK06817"/>
        <property type="gene ID" value="Theba_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1112"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_51_1_0"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="188"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="498"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="532"/>
            <end position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="741" mass="82242" checksum="EAA0417C0D1C0138" modified="2012-07-11" version="1" precursor="true">MLKLIRYLKPYTVFIIVAVALLFVQAMAELALPDYMSNIVNVGIQQGGIEDAVPEAISKEAFDNVSLFMSGEDRQKVLSHYDLITKDSATYEENLKKYPALESKDVYVLKPGEIEDRQALSLIFGKALMAYSGVKNGMTGSNGSFAPPEGFKIPEGANVFLLMRLMPEAQRLEMLNQIDSMVEVMGENVVSQSAALVVKEIYEELGVDTTKLQSDYVLSTGLVMVLVTLLSTLSTIMVAFIASKIAAASARRMRRDVFEKVENFSNSEFARFSTASLITRTTNDITQIQLVIVLIIRMAFYAPIIGVGGIIRALEKSTSMSWIIALAVIIMLGLIGIVFAIALPKFKKIQKLIDRLNLVTREHLSGLMVVRAFNAQEFEEERFDAVNKDLTRTDLFVHRVMVVMMPAMMFVMNGTMLLIVWVGAHQIEASTMQVGDMMAYIQYAMLIIFAFLMFTMMFIMIPRASVSAARVSEILEVDPQIKDPKNPKKFGSDFKGTVEFKNVCYRFPGAEKNILNDISFTALPGQTTAIIGSTGSGKSTLLNMIPRFYDVCGGQVLVDGIDIREVNQHELREKIGYVPQKGILFSGTIESNLRYANENASDEEIKRAAEIAQALEFIRAKEEGFDSPISQGGTNVSGGQKQRLSIARALLKRPKILLFDDSFSALDFKTDAALRRKLKRETGDSTMIIVGQRIATIKNADQILVLDEGNLVGIGKHHELMKSCQIYREIAQSQLSEAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K6</accession>
    <name>I2F4K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730848.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1161"/>
    <dbReference type="EnsemblBacteria" id="AFK06859">
        <property type="protein sequence ID" value="AFK06859"/>
        <property type="gene ID" value="Theba_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1161"/>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066201_0_0_0"/>
    <dbReference type="OrthoDB" id="798280at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="38614" checksum="79149FF5B6A6EEEB" modified="2012-07-11" version="1">MYRIANETSSNLRAIFGNTATRRGISPAIIEKDFWVCFLLEVLFHHSKYSKHYAFKGGTSLSKVYKAIERFSEDINLIVDWRLLGYSLTQPWESRSRTKQESFNQEAALRTERFVATEFVPSLEESLSSFIKDFDLHVDPDDSQTVLFRYPQIFADQSLLQEIRLEIGPLAAWSPSGDKPITPYAAEEFPKAFRMPSTLVRTVEAKRTFWEKATILHREANRKNGRLPLRYSRHYYDLHMLCNTSIKREALEDIELLYKVVAFKDKFFHCAWAKYEEALPATLRLVPPNNVLKKLEEDFEKMKPMIFGSVPSFEQILATLREFEQEMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M4</accession>
    <name>I2F4M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730866.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1179"/>
    <dbReference type="EnsemblBacteria" id="AFK06877">
        <property type="protein sequence ID" value="AFK06877"/>
        <property type="gene ID" value="Theba_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1179"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_0_0"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="175"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="379" mass="42685" checksum="3D3E499A1F1E6D26" modified="2012-07-11" version="1">MKKLRAALIGCGRIGTKKHIEAFAANSDLIDLVAVCDLVPEKAERAAEEYMKRREISLNRGDEERIGEKNETKNDQNEFSSSPASEPDLQRPRVISDYKELFSSQIDFVTIATESGNHYKNTIDFLSAGKHVLVEKPMALASEHMDQMIALSREKNLKLAVCVQNRFNPPVQELRKAIDSGKFGRVFTATARILWNRNEEYYKQASWRGTWAMDGGTIMNQCAHNIDLLQWMLGGEVQEIFAMTENYKHPYIETEDFGAAIVRFKNGSIGIIEGTANVYPRNLEETLSVFGEKGTVVLGGLAVNKIQTWKFEGEESHPFMYLPDPDTVYGSGHMTAFKDFARAIIDDREPFVNGEEGKKSVEIILGIYKSAREGIPVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N5</accession>
    <name>I2F4N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730876.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1190"/>
    <dbReference type="EnsemblBacteria" id="AFK06888">
        <property type="protein sequence ID" value="AFK06888"/>
        <property type="gene ID" value="Theba_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1190"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087902_0_0_0"/>
    <dbReference type="OrthoDB" id="1485176at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiEi_1" evidence="1">
        <location>
            <begin position="74"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="257" mass="30055" checksum="025259D322E3E921" modified="2012-07-11" version="1">MKYYEQLARLGVFTKSDVEKLVGKSETAGSLLQNYKRRGLIDQVKRNLYVTKSLETGQAIAGRYRIASKIKPRSYITHHSAFEYYGYANQVYYEVYVSAETKFAEFSYHDVRYRFISPRIHDGVVMNPDGVRTTDVERTTLDSINDFERIGGLEELLNCLDAVPSLSERRLVSYLGQYNKRFLYQKTGYILSHFQEKFRLSKGFFELCEHEKGKSVRYFYNAIRFESPTYDSRWKLLVPQELLEIVSKGVKDTGEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U6</accession>
    <name>I2F4U6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730930.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1261"/>
    <dbReference type="EnsemblBacteria" id="AFK06949">
        <property type="protein sequence ID" value="AFK06949"/>
        <property type="gene ID" value="Theba_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1261"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_4_0"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="29862" checksum="21973A759C3A555B" modified="2012-07-11" version="1">MDNLLLNNFSKKIRVYLPELWRKVSKEEFSIERKSGYKDIVTSVDLEIEDNLRVFLHDLYPEAAYLGEESGPDVRSSTMWIVDPVDGTTNFSKSNPHYSTQIALYSEGRVVLGVTYDHNRRETFHAIEGQGAYLNNKRIWVSKTRELREATSHVGMQYSSETAFERITRRINRAIKICRGLRITGSACLDFAYVASGRADIFWEETLKPWDVASGILLVKEAGGFVGSCVEEDFDLFNPNVLVANNSPELVKEFRDRVLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F541</accession>
    <name>I2F541_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730990.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1356"/>
    <dbReference type="EnsemblBacteria" id="AFK07044">
        <property type="protein sequence ID" value="AFK07044"/>
        <property type="gene ID" value="Theba_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1356"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="163"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="224"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="425" mass="47030" checksum="3714385E6FF6E09C" modified="2012-07-11" version="1" precursor="true">MSDRRKLSTATQVAIYSVVLIVSILFASAIFVYGVSESVFIRNYSAEMRKIFMDSPMGKGFRYGVGRMAIGRGTTEFYVSVDGNVVQNPTGLSSVPDVEGYVKTRIDGSSYLLYGFLNGEEKVILGARMDDLDFFLESLATTLLLSVLVGVVLSIIGGLFLGSRVSKPIKETSRLLKEITLNDLSRRLESDPKTSELAELKKALNRALDRIQDGYTRQEQFSSDIAHEIRSPLTSILGFSRLILRWGSDDPEVVKEAAESISDTATKMMTITESLLFLSRPEIELNETSFNLRELVLEITNSVPADQSAEMKIEIPDIEVRTDRVLLKIIVKILVENALKFGKNGPIEINWSDGTLSVRDHGMGINEDEKERIFNRFYRGDSSRGGEGHGLGLSIASKICKVLKLSIDADNCEDGGAVFKVEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F548</accession>
    <name>I2F548_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1363"/>
    <dbReference type="EnsemblBacteria" id="AFK07051">
        <property type="protein sequence ID" value="AFK07051"/>
        <property type="gene ID" value="Theba_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1363"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="27301" checksum="21303C5D6A3F8D28" modified="2012-07-11" version="1">MINLKKALITGASSGIGEIFSYELAKRGFGTVLVARRYDRLEAISNRIERDYGIVSTPLKADLTSESDLLRVSESLNEVDLLINNAGFGMIGQFEDLETDREMQMINLNIGALYYLTKKYTLCRVGIGGGVINVASTAAYLPVPGMAVYAATKAFVLSFSEAISEELKSKGFKVMVLSPGPTKTEFFDVASGGRKKLPGSMSPEEVVRRALDSFEKGKRSVVSGVINKVIATGSRLVPRAVALKAARRAFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F583</accession>
    <name>I2F583_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1398"/>
    <dbReference type="EnsemblBacteria" id="AFK07086">
        <property type="protein sequence ID" value="AFK07086"/>
        <property type="gene ID" value="Theba_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1398"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_0"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="91"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="36922" checksum="3F4C28C43E8A7005" modified="2012-07-11" version="1" precursor="true">MCILEKLLIVFFGICALGANFFRTERLFAYETKEVSSNCALNVNMRSEEHRTHKSDRRDLVMERSIAEQYVRIVDKKIFYLETVGDDGIPVVFVHGNFASSKWFEPALKILPSGLKGYAIDLPNFGRSDRLEEVSIDNYANYVINFILEMELDGVVLVGHSLGGAVAQSAVIKRPDLIDRVILVDPAPPDGLKTPEEVYPYLEMYRGNRELLKKALIGVMPTREVDEFLEQLVDEALLMDGRCFVENARALEKYDFTEALSEIEVPHLVVVGKLDNIVTEEMARRFERILRDVEIRVLPDYGHSVILEDTELFVKILEDFVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F591</accession>
    <name>I2F591_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731039.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1406"/>
    <dbReference type="EnsemblBacteria" id="AFK07094">
        <property type="protein sequence ID" value="AFK07094"/>
        <property type="gene ID" value="Theba_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1406"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058230_0_0_0"/>
    <dbReference type="OrthoDB" id="1482719at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="392" mass="45503" checksum="16C119E8D0174317" modified="2012-07-11" version="1" precursor="true">MKVSRSERTRLQIKEAAEELFSRLGFEMTSVANICRTCGLSNGAFYRHYTGKEQVFKEIVQDIKTRFESASASVMGNTVEEKLYNLYRKVFDILWQSRRKFIAFHEAEYRFPEVENSVDKTYKDALLSTVINDRSPLSMPELWFLIGSSRFAAIYWIIYNDTRVPDSTVRSLVDFTLNGFVKSEELDRRSLEFTLDRVRANGEGKAKEVILLAAEKLMGEKGYFGTSIYDITSKAGYGQGTFYLHFESKGKLLQELVYQANRNLRRTMRDAVSGVEGRLNKEIRSFKAFLLFMDVHKELYNIVRESEFVQPETGRFYYERLLTSYIRALEEARLKDEIRSIDSRDLGVFLMGIGHFMGLDLLFKLKKDYEKWNEYLLELASLMAKGYGGAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C0</accession>
    <name>I2F5C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731067.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1437"/>
    <dbReference type="EnsemblBacteria" id="AFK07123">
        <property type="protein sequence ID" value="AFK07123"/>
        <property type="gene ID" value="Theba_1437"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1437"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449640_0_0_0"/>
    <dbReference type="OrthoDB" id="185609at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="201"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="607" mass="68092" checksum="CFD9F26FBFCCA142" modified="2012-07-11" version="1">MNQAWERKARVLVVGDVFLDKYVYYDPNLSRPSLETGLMTITGVREEYSPGAAGNVAKNLATLDGKVILLAPVGLDARAVELERELNRYGICTQFLVKSERQVTPLYMKFINALTGKEDLPRLDIPPAGLVEENRRKIVEMLEFLVPQVDAIIVQDQSEIPGTGCIDEEVRKQLIVLRKLFPEKLFVADSRNWLETFSGFLLKPNLGEFSQILERAGLVDDNNRCPDQILVQKHLAEVSKLVSSPVVVTASEDGSFCFKNGILNRIFNLEGEVRDVCGAGDAFIAALTLELCVKKVSLLDSAKTATKAASLCVSQKGTGVLLRESISKLEEPNAYRVEDPSIFRNTRRLPGKTRYVLFDFDGTISLLREGWQPIMRDLMIHFITGDREIEEETRKKIKEEVNDFIAETTGLQTILQMEGLQRLVIDYGFVSEKEILNPHQYKQVYTGHLKEIVRKRINEDSRDRYLVCGSLEFVKSLHERGITLLVASGTDLEDVIEESKYLGVYDFMGGGVYGALSSFEEYSKKKVIQRLLTDRKLQPDELIVIGDGPVEISVGKEAGAFTIGVASDERKGFGWNKEKFNRLKRAGADVLIPDFSPLSALIELIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E4</accession>
    <name>I2F5E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731081.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1462"/>
    <dbReference type="EnsemblBacteria" id="AFK07147">
        <property type="protein sequence ID" value="AFK07147"/>
        <property type="gene ID" value="Theba_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1462"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_0"/>
    <dbReference type="OrthoDB" id="944891at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="29202" checksum="51BFB69077B24AC7" modified="2012-07-11" version="1" precursor="true">MIQYGDSILIMLEHEEAKYFSEVKRGSVLKTHYGNLIMDSLVGREFGEKIRLGLRDAFLIKPSMIDGIFSLKRSTQIVYPKDVAFILLYLDIKPGDVVYEAGTGTGVMTSAFSRAVCESGKVVSYEKRQDFLEKAQKNVRHLGHIERVTFVSGDVAECKESQKADAFFLDVPEPSASLESAVSILKKSGRICILCPTANQVQETVTILGTLGIIDIQVWEILARSYKANPERFRPEDRMVGHTTYLVFGIKVEGRKLNGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E9</accession>
    <name>I2F5E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731086.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1467"/>
    <dbReference type="EnsemblBacteria" id="AFK07152">
        <property type="protein sequence ID" value="AFK07152"/>
        <property type="gene ID" value="Theba_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1467"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_4_0_0"/>
    <dbReference type="OrthoDB" id="900869at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="1">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="206" mass="23366" checksum="ED4B67DAB915D11E" modified="2012-07-11" version="1">MTYAIGDIHGCLSPLKRLISALDLKDDDSLVFIGDYVDRGPNPRGVIDFLIALSANYECHFIRGNHEQMFLDYLNGVQGSTIWAYNGMETTIRSYGTIRSIPEYHIEFLNNTVLYYEEKSFIFVHAGVRPGIPLKKQDPKDLLWIREPFLESSYPIKGRTVVYGHTPLISGPLIQEGKIGIDTGCVYGGFLTAYRVDDNFYLSERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F3</accession>
    <name>I2F5F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1473"/>
    <dbReference type="EnsemblBacteria" id="AFK07156">
        <property type="protein sequence ID" value="AFK07156"/>
        <property type="gene ID" value="Theba_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1473"/>
    <dbReference type="HOGENOM" id="CLU_211547_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="57" mass="6331" checksum="F0083F73B81DF17B" modified="2012-07-11" version="1" precursor="true">MLNSSSVGLRISTDPVQEMTVKYPRVLVIKAAFCLLKDGKSIEHRDLEKTLQTLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F4</accession>
    <name>I2F5F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">Theba_1474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731090.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1474"/>
    <dbReference type="EnsemblBacteria" id="AFK07157">
        <property type="protein sequence ID" value="AFK07157"/>
        <property type="gene ID" value="Theba_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1474"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_0"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="11"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="406"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK07157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="628" mass="69957" checksum="AB81DA7FFFD2C8A3" modified="2012-07-11" version="1">MRSNKRDYEFDIIVIGAGHAGIEAAIAGARMGMKTLILNINLDTVGWTPCNPAMGGPAKGIVVREIDVLGGEIAKSTDQASLNIRILNTSKGAAVRALRAQVDKIRYSQTMKRSMEMQENLFIQSGIVKAIETEKGSVKGVITNFGLRYSARSVIVASGTFLGGKIFIGPHEFPAGRLGEFPSTELTGSLRSIGFEVRRFKTGTPARIAGRSIDFAEMERQGTSETPLCFSHFSEPYVLEDDHPCWLTRTNKETHDIIKRDLHFSPLYGDLKLIDSRGPRYCPSIEDKVIKFSSKDSHQLFVEPESAYSNEYYLNGLSTSLPYETQLEMIRTIPGLGRAEIVRPAYAIEYDYINPTQLYSTLESKVVENLYFAGQVNGTSGYEEAAGQGLIAGINASAKLLGEKQLVLSRSEAYIGVMIDDLVTKGVDEPYRLLTSRAEYRLLLRHDNAHIRLTEYGYRYGLVPAWFKERVDSLTREIKTQLIRLQKINVRPSEGLNELLISKGSSKIDLPVKFSSLLKRAGVGYRDISMFDPEPILDDDVIGQVEIEVKYSGYIDRLKAEVKRLEEIEEDLIPSTMDYDAVSNLSTEAKEKLKKTKPASVGQAMRIPGLTPSDIMNLSFHLKHEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J2</accession>
    <name>I2F5J2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">Theba_1513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731116.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1513"/>
    <dbReference type="EnsemblBacteria" id="AFK07195">
        <property type="protein sequence ID" value="AFK07195"/>
        <property type="gene ID" value="Theba_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1513"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_0"/>
    <dbReference type="OrthoDB" id="347113at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="187"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="694" mass="76778" checksum="4C282998371A8883" modified="2012-07-11" version="1">MPKARVYELAKRLNITARELLDELEELGVTVKNHMSVLDEETVNIIVGLYEEEKKETLRKAEKAKSKIQEKEAKKLEKKLVSIEEPPTEKKIPVEHKARTIKLKSNEFKLDVLAKKMNVPVSKVIKDQFMNGIILRPGQILSVEDAMNIAKNYEWEVELIHEQEINPFDAIVSAYSDAYKESSRLVQRPPVVTVMGHVDHGKTTLLDRIRKAKVAEDEIGGITQTIGAYQVEVRNKKITFIDTPGHEAFTEMRARGAQATDIVVLVVAADDGVMPQTIEAYNHAKTANVPIIVAINKIDKPNANVDLTKQQLASKLGLVPEDWGGDTVMVPVSAKTGKGVEDVLEMILLVAEVADIKCIPEGNARGIIIDSRLDKAVGPLATLVIKDGVLKPGSYVVAGSASGRVKALINEYGKRVKEANPSDPVQIIGFDEVPDVHSIVYAVDDLDTSRSLADFAKSQAQKEKSVTTKRHVRLEEFLSMTGTTDEKKELKLILKADSFGTVEALKQAMAKLENSDVKIEVVHSGIGSVNSSDVMLASASDAVIMGFKVKPDAMARKQAEVEGVQIKVYEIIFNLIDDLKKALEGLLEPEEVDEVIGHGHIKQLFKISKVGTIAGVQINDGYVLKKGKMRVYRRNEEVADLAIEVLKHYKDDVSRVDAPKECGIKAVGFDDFQEEDQLEFHSKKSVKRTIDFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J7</accession>
    <name>I2F5J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sugar phosphatase of HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731121.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1524"/>
    <dbReference type="EnsemblBacteria" id="AFK07200">
        <property type="protein sequence ID" value="AFK07200"/>
        <property type="gene ID" value="Theba_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1524"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_0"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="29126" checksum="DFD7C9BC53AB4821" modified="2012-07-11" version="1">MLTNKRLFVSDMDGTFYLGDGLLKGSLEFANAVHRLGSKLVFLTNNSSRTPEEYIRKLTKMGVDRTLFEVYTSGEATISFLKRDFPNKRVFLLSTPSVREMFRKSGVNLDDNSPELLVLAYDTTINYERIRKAALFIRQGIPFIATHPDVNCPTEDGPVPDVGSFLSLFEASTGRRPDNIIGKPDPTILKMVMDDFGYGPEETVMIGDRIYTDIECGLSAGVDTYLVLSGETTADMVPDSHSYEVVNNIGSIIEIIERGNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K7</accession>
    <name>I2F5K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family 31 glycosyl hydrolase, alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731127.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1534"/>
    <dbReference type="EnsemblBacteria" id="AFK07210">
        <property type="protein sequence ID" value="AFK07210"/>
        <property type="gene ID" value="Theba_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1534"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_0"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="4">
        <location>
            <begin position="665"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="749" mass="85625" checksum="9A1CFDD1916CDC1E" modified="2012-07-11" version="1">MKKRFFRYLNSVVKVSVVREGKTKLKSGAVIIEPEEELDELGACQLLGVLDLGQARTFVSRAGNEMNVAENDAGYVVNITLQKNQAVLGLGETMGPLNKRGSIYEMYNTDEPDHSPSKRRLYSSLPVFHIVSPEEQFALFLDHPGYSSFDIGFENRDTIKISIEGDGFDLFIFVGSPSDTIRRIFKLTGNPLLFPAWSLGYHQSRWSYANEEAVLEIAENFRRRRIPCDAIHLDIDYMDDFKVFTWDKNRFPNPSSLTAKLSSMGIKTVAIIDPGVKAQDGFDIYEEGQKKDLFCLRKDGSPFRAAVWPGESRLPDFLNSAAREWWGQHYDRLIKNGVSGFWNDMNEPAIFYTPESLLELKLMAEELHDSGIETEFLFGKIISKKKYYDHGVDFVQKDDDGNTHSHREVRNIYGFNMARSAYEGIRKSKSDLRPFNITRSSYPGIQRYAVLWTGDNASQWEQLLNEIRLIQSISLAGVSFTGCDVGGFGDDCSGELLVRWTQFGAFLPFFRNHSAIGTRNQEPWAFDKEVEELVREAIELRYSLLPYLYSVHKQSANGEMTMVRPLALIWPGDSETYYADDQFMIGPSIMVAPVYQRNSEGRHVYLPGEEWLDLNTRKVVNSGHSWAKAPLNIIPYFLKKDSLIAMTDGLQFVKSGSWKTLKFLGFVKDRAEFYLYEDDGLTEAYKRGEYSSKTIIVDNTSNGLKVEVKPQEGSFKCDERRIEFEIHDGRKLYKRSIIDSPDGYEFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N4</accession>
    <name>I2F5N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1565"/>
    <dbReference type="EnsemblBacteria" id="AFK07237">
        <property type="protein sequence ID" value="AFK07237"/>
        <property type="gene ID" value="Theba_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1565"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022176_3_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="398"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="521" mass="59022" checksum="A6F218B5C2EBB539" modified="2012-07-11" version="1">MDHIKQEKSFADLYEEYLSKDESEFDSRISFLKRIQRSLVDSGETQIAFEIVGRELEKIGNQCSSELGFVYNSMIRISCQSGEFSKALEYAASAISVFDELGDDSRLPMIYNNIAGVYLKMGEFETSLEYIDKAIDLSQRNNDNHSLAKYLNNKGIAVENIKGDGSGAVFIEKAIELKEENSLKSDLPNSYMNLADIYTYTGKEDEAHSLLKRAREVANEIEDEFSLAEVCRYEANYYRAVGELGSALESLNTSLEYHKSKGNKSEILQRLTVISEIQEIVGDVKGALETHREISKLNAEIFKEEEARMVAKLQSSFSTMQKLKEIESMARRNRQLDEANRLIVQKNEELLEMQSQLSSANQLLKERAETDSLTGLMNQKKMFEIVEYEINRAKRYGNRLSIIMLDIDDFKVINDTFGHQKGDGILESLSSLIISSIRKIDYAFRYGGEEFVILLPSTGVEGAFSTAQRISESLKRTNEIPVTISIGVAEWSDESVNDLLLEVDTLMYEAKNTGKNRIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P8</accession>
    <name>I2F5P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_1581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731157.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1581"/>
    <dbReference type="EnsemblBacteria" id="AFK07251">
        <property type="protein sequence ID" value="AFK07251"/>
        <property type="gene ID" value="Theba_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1581"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001114_1_3_0"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="317"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="969" mass="110678" checksum="06479F5885B1263D" modified="2012-07-11" version="1">MNKDIFVTASAGTGKTFSLVKEYVGVFDRSFRIGERLDVHNVVAITFTNKAAREMKDRVITEIDHRIASGHPGSWKPLRNKMSYAWISTIHSFCERILRESALFAGIDPGFQILSGMRRATLEEKVVRTYFEDNLESLEPLIQLTGLDKAFRIVKEAISSKRHSLALNPSPVGSLLGDSIISDDEIIEGSKSFAAAYSEILSDYRDRTVRSGFLDFDQLLTETRDLLLKMPEVQEKYRDRFKFIFVDEFQDTDELQSEIIRLLREESKNRVFFVGDSKQSIYRFRGADVSVFNKTMKSFQNNGGELRNLRINRRSHPDLVTFQNKLFGKIMKRDFENEFFRSIYDEDIESLPYQRDIESSRVRIIRTESSDDSREVARSVRALIEEELVFKTKTGEYEKRRIVPGDIAILLRTFSKISSYENALEKLNIPFYTVGSRNFYEQPEVSGLLSWLDLLVDPLDNNNLVSFLLSPAFGASLDEVLTLRSKRDLRRLPLYFALMESKEDRFAHLIDLLKKFGKLKYILSPSEILEKFVQETDYLPKLATLKSGERMIANVKKLLELAKDLDRMGSSLRELSSNIKAFIDSSDESEAALETEESDSVKILTVHKSKGLEFPIVIVGDTFWKKKNSDRRLFFHDGGFLISKSKPDREEGLIGSLASLEEEKEFEEEKRTLYVALSRAREMIIISLNGRSDSSRPWSKMICSSLLQSESDKVEASFEGIVKHFYPIDLPSIQETVYIEEPLLPEVTSVLPLTDSSYIKYLSPTSITADDEFELQSESYAGSPGLVKNAAGIGLLAHYLLEPVGVISKRGSVTTLESILNGGRPVSVDRINFNEYDLSEVKKVLSTLVAHPLIKEIEGAERVFSEFHFQHGFGKYVLMGIVDKLYLKDGKWRIVDFKFASLNKRFINKYRFQMNLYLYILKDLLSPIEATLLFLRDGKTEKIMLEDSDSFEKELLQMISKAGGGKNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P9</accession>
    <name>I2F5P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731158.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1582"/>
    <dbReference type="EnsemblBacteria" id="AFK07252">
        <property type="protein sequence ID" value="AFK07252"/>
        <property type="gene ID" value="Theba_1582"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1582"/>
    <dbReference type="eggNOG" id="COG3857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010384_0_0_0"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="748"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1025" mass="118382" checksum="9372F88CA434A0D3" modified="2012-07-11" version="1">MKITLFIGPLASAKTERLLRELETVHWRDPFSYFFVGPSGDHVRYFRENFISRVGTIPASRFLAMDQFAVEVFRRLNPNSIHVGNHLMRLEIGDILDQMGKGELADSPVFVEYLLEMIHDVKENRGFDRIFSTEDEAVSVLESIYNELDSRFSRRNIFDTFDAYTRIEEHKDELINEEFGDTLFLDGFHDFSPALKIFFKTIIPTYREVFITITQEPDKESLFSNIDSILETIDEIAENSTDLEIKRIFFEKSPSSSGLNGFKEALFSPGKVEQNCDSVSVVVYPDIFAEVEGVSRFVKESIISACEPGDISIVSSDFNLYSKLLSDKLNEYGVPHRIEGDEELHSSLSIRRLILPLETAVLGFPPEKIIAMADSGYGGEVDSSFIESAAAMSRIIYERPNMWLSLEKRRSSWDERLSRLVDLMKERRNAIISLADDELEMSAAEELDEAIERIDSEVVPAVQRIFRLLDSFRSLRKRDVGNYRKMFITWEKELSLIQSLTGYESEVKDREMDAIVRFFEYTLPYLERLLYFMGKSSVSPKEYYRYLMLLLKHDKFPLSRNKANRVEIQSLINSRFSKKRMKVFVGFVDGAYPHVEMNPLYSFTQFGDSRPRDLLLDEETHERLNLYLSISTAEESVRFSLPESTIDGEPILPSPYLKNVAESSGCETTREGRKVGRRSGYIPELRASMSQSELKISAAKFFLNEKWDLLKSFPPLSNLDTVLSNFRRDFSWSVQNRRRLEEVVGNVFSFSRLKSYHDCPFSFFLSYVVGLDVSPEHVFELTPLDEGNIFHSVLKDFFSGKNRDWQDSLAENIKRHLMHDSNIVFRFEFERLSEVLHEYITVREGKRPNFMGDNFIPYAFEKAFGIGETEPVKLLENLYLRGKIDRVDIDRSSSSVYLIDYKRGDSGDERQLLLYSLVAEKLLEDESLDVAGGVFKTLTGKTVNKAAFRTISSEGGKVWEFAGKKKDNRIVKESDLLKWLKEVHEGIYSGEFTPSFTVSASKCYSCRFSEIKRSITWREGRKEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5U1</accession>
    <name>I2F5U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731193.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1630"/>
    <dbReference type="EnsemblBacteria" id="AFK07294">
        <property type="protein sequence ID" value="AFK07294"/>
        <property type="gene ID" value="Theba_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1630"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598268_0_0_0"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="210"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="457" mass="52260" checksum="64AD635FFDB7C464" modified="2012-07-11" version="1">MRVFIVEKGFEEHELRVLKEIVDSLVSSKEDLREKVEIVELSEFREEQGIMIISQQVIGELNPERSSGQLFIMFKGGLESNIVGFAQRMGAVGIFPIDRFYGERMEYGEISRFENVLKNVLRDRLSTRFPEWDFKKRIDWKMKLDDKAFEDEDAYISLFGDEITHKNVKKTNEIITSVMPYVKELKTFRLKSKRVLEELKKKELSEDPKLEGARIAIRKLNDLTSEMKFRKPVCILLTGPTGCGKTLLAKYIANSLFGSLETFSRISLVNMGDNLLESELFGSFPGSWTGSSYKVGKMVSMAGGAVFLDEIGEISPAIQAKLLTYLDDMKVLIEGLSDTSGVRVPVLIIAATNRDVRKEMSLGNFRSDFYQRFAYEIHMPSLSERKSDFRYILSHLLQVKKKILNLSIDEISIAAIEKLEGYEYPGNYRELERVVTAAMMSAKMDGREIVLSRDVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X5</accession>
    <name>I2F5X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731223.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07328">
        <property type="protein sequence ID" value="AFK07328"/>
        <property type="gene ID" value="Theba_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1666"/>
    <dbReference type="HOGENOM" id="CLU_1060931_0_0_0"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="28005" checksum="97DC0E53975B857C" modified="2012-07-11" version="1" precursor="true">MKRFFVPLMIVVLIFLLSGCIWGDKPLPKIVLIDDSHANRFGGEESEFFDGIIAILAAKGYDYKYSSVEGFEPQNYAIVILSMPGASYSTSDIDKLETQLSKKGKIIMMDILAEVPPASTFFLDALSDGLNTGIGFVWGLVTDTVNNIGGNKMMITTDNFTTHPLASTLSAKIAMMMATKLTVEGNATVAIFAESSAIFTTYVPSGDEVTYVPEATPPIPIVVASNIGGGKVVAISSAYAFTGTLMGIVPGNTDLFRAAVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F609</accession>
    <name>I2F609_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1703</name>
        <name evidence="3" type="ORF">Theba_1770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731256.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1703"/>
    <dbReference type="EnsemblBacteria" id="AFK07362">
        <property type="protein sequence ID" value="AFK07362"/>
        <property type="gene ID" value="Theba_1703"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07425">
        <property type="protein sequence ID" value="AFK07425"/>
        <property type="gene ID" value="Theba_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1703"/>
    <dbReference type="KEGG" id="mpg:Theba_1770"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_0"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="270" mass="28938" checksum="F83E66BCF43D832D" modified="2012-07-11" version="1">MNNSKKAKNHLQISSDSIPEIALLPGDPARVYEIAECLSNVEEIGNNRDYITVTGTYKGLPLTVCSSGIGGPSTEIAVVELNRLGVKTIIRVGTSGGLADDVKPGDLIVLSSCIRYSGTANLFIPENFPAVADYRLLTALISACEEAGVDYHVGIGLSLDSFYATKPDLLREDFPSSIYGKLEEWIAAGALQLDMEAATLYVLSSLLKINAAAICTAGSNISRGERPETPPSNKNAIRAACEAAYKFNNWKKISVKRGRNFTLPPIAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F680</accession>
    <name>I2F680_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731267.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1782"/>
    <dbReference type="EnsemblBacteria" id="AFK07433">
        <property type="protein sequence ID" value="AFK07433"/>
        <property type="gene ID" value="Theba_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1782"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="80"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="542" mass="61807" checksum="DA2FD117A88B62E2" modified="2012-07-11" version="1" precursor="true">MRRLFLVGILLILLTSSFAEVLKRRGTEEEFSYSELAGGSITLPVDTTFRFIPGFELSEGDFWVTFAIQDPLFRWASGDELSPCLVEKYELLNSNKSLIIKLRDDIFWYDGTPITSADLEYSIKAWKSTESSPVYEALNDPRFGWFSVVDGKTVVFNFNDSYPEFLNSLRTGILAKHIYSDRLGIEPESLEENMEMDKPPVEATSGSFMLDPASVKGNIILKRNPNWHGGSGDDLFPLVFESWPGKSLLDEIRLVEVAEPLDRIEMFDAGELHLLFSEPDHNESLLSEAASGKFKSGSFPDGSYHVILINHRNALLAERGVRQALKMSLDYESLLEALPNSIGTFIPVDPRTSIFKTLQAQIVDLPYDPDKAKTFLSNAGYPGSITLSIKVYHGIENILLEELQKSWDKIGVKLEVERLDWGSLLRDIDEGDYELVYLRVEAFDYPEIAPWTNEYEHDLKTGWEVGYVNPQIFRIMRRAAIETDWRKRAPYYLGSYRIWTNDVPVLVLAYNLSYAFWNSQLSGPVPGRGELYENLAEWYLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6A3</accession>
    <name>I2F6A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase 20 kD subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731286.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1805"/>
    <dbReference type="EnsemblBacteria" id="AFK07456">
        <property type="protein sequence ID" value="AFK07456"/>
        <property type="gene ID" value="Theba_1805"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1805"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_0"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="179" mass="20594" checksum="B7F68EC19A4FECF2" modified="2012-07-11" version="1" precursor="true">MSEERKAWEKVANMLRSRSLWMLYYCTGCGAIELPPTMTSRFDMERLGIGPMATPRQADIMLITGYLSTKTLRRVIYSYEQMQSPKYIVGFGSCTLNGGIYYDSYATINKLDLYVPVDLYLAGCMPRPEAIVSGFTALMSKIDKGEANGWKEYKEKNDWYKRNQIEALGEVYVHDEFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6A5</accession>
    <name>I2F6A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase 49 kD subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1807"/>
    <dbReference type="EnsemblBacteria" id="AFK07458">
        <property type="protein sequence ID" value="AFK07458"/>
        <property type="gene ID" value="Theba_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1807"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="122"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="370" mass="41783" checksum="6255AEC0B1D481E5" modified="2012-07-11" version="1">MKMSKEVKLFLGPNHPGMHGNSSVHLYVEGDTVVRSRLVPGFLHRGFEKLMERRGWMQNLALIPRICVPEPDINEMVYAMAVEALTGTEVPERAHWIRMIILELARIASHLMALGGVGGSTGLYTISHWTLADRDRILDIFEKITGARIYHMYIVPGGVRKDLPEGIESEIVEFLDYIESRSDEFENLLLKNRIIRTRTEGLALLTREEALEIGVTGVGLRATGLPYDIRKIDPYAKYDSVAFDIPTATEGDAFARFTLKYYEMMQSIRILRQVLEKMPEGPVNAKISSGSALRWRVPEGTVYTHIESSRGEYGYFVVSDGGERPYRINVRGASFPQGLYGVEKLLAGTRIEDVALWLTTMDFCPPEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I2</accession>
    <name>I2F6I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hexose kinase, 1-phosphofructokinase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1887"/>
    <dbReference type="EnsemblBacteria" id="AFK07535">
        <property type="protein sequence ID" value="AFK07535"/>
        <property type="gene ID" value="Theba_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1887"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_0_2_0"/>
    <dbReference type="OrthoDB" id="1323781at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="12"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="309" mass="33732" checksum="2225022381364020" modified="2012-07-11" version="1">MVIFSLTLNAALDRFLYTDALIEDDTVRVDRVKDYPAGKGVDVSRVINELGGHSVAVAFLGGHTGKVIEEMLDDEGVVYATVRSEEETRTNILVQTGSGQYRMSLPGPVISVKEVYKLYKTIDVLLRKDDYLLLCGSIPEGVSSDIYAQLCSRMRKIGVNVYIDSDKEPFSKGVEAKPRGIKPNIHELQRLLNRELIGEIDFRKAISEVSNKYSIEEILLTMGAEGAIASVSGEFYRIRVPKVPVKSGVGAGDSFLAAYCMYRELGETVKTALKMAGAASSAAVMTPGTELCRFDDVMSLASKIAVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K9</accession>
    <name>I2F6K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg chelatase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731364.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1915"/>
    <dbReference type="EnsemblBacteria" id="AFK07562">
        <property type="protein sequence ID" value="AFK07562"/>
        <property type="gene ID" value="Theba_1915"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1915"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_0"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="1">
        <location>
            <begin position="292"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="503" mass="55494" checksum="10954835F8FCDF40" modified="2012-07-11" version="1">MRYSRVRTVTTVGLKVLDVLVELDIDSRAVIQEMDIVGLGDTVIKESKKRVKSAVKNSGIELPNGRITVNLAPSDVKKEGSYLDLPIAVGLLKATSKINADLSDFVFFGELGLDGSLRRVRGVLPILLSLSRRAKGMKIVLPAPNRQEASIVDNLTIFTADNLNDLVGFLNGYIEKSPIAYSQPELGNVSGPDMSEIKGQEFAKRASEVAAAGGHNISLRGSPGCGKTMLARRIPSILPPLTMEEAIETTMIYSVAGLLGEKGLIKERPFRSPHHTASTTSIVGGGNDAKPGEISLAHNGVLFMDEFPEFRRDVIEALRQPLEDGVITVARAKLTATYPARFMMVAAQNPCPCGWYGDKTRECTCSWYDIQRYNRKISGPMEDRIDIFVDMPRLDFDKYMENSTTESSDEIRKRVIAARKRQSERYEGMSIFSNSQLGHALLKEYVPLDTASRSLLSAAMDKMKLTARAIDRVLKVALTVADLEESKVEARHIAEALQYRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M7</accession>
    <name>I2F6M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731382.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1934"/>
    <dbReference type="EnsemblBacteria" id="AFK07580">
        <property type="protein sequence ID" value="AFK07580"/>
        <property type="gene ID" value="Theba_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1934"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_9_0"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="35265" checksum="FF5D9DAB2AD15078" modified="2012-07-11" version="1" precursor="true">MKFIVIVVSLLSVVLIAPFLIPVRDLEGTVDPLLLADEDSMFVNIKNINIHYKSAGEGSTLVLLLHGFGASTFSWREVIGPLAEEYFVVAFDRPGFGFTSRPLGKDLEVFNPYSMEGQVELTVSLIEHLGYEEAILIGNSAGGLTALEVAASYPQKVKGLVLVDAAVYTNDADNPFFNLLTNTPQGRHLGPLVSRIFLGNSRNLLDLAWYDTSKLTPDILEGYEKPLKAENWDRALWELTLARKPYDYSKIPVIYVPSLVITGDNDRIVPVEDSVRLAKELPLAQLSIIPDTGHLPHEESPGEFLEIVLPFLRSLATMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P8</accession>
    <name>I2F6P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine-1-phosphate uridylyltransferase/acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731396.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1956"/>
    <dbReference type="EnsemblBacteria" id="AFK07601">
        <property type="protein sequence ID" value="AFK07601"/>
        <property type="gene ID" value="Theba_1956"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1956"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065567_2_0_0"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="239" mass="26668" checksum="3FB47574214713A9" modified="2012-07-11" version="1">MLVPVILAAGKGKRLKSEVPKPLVKIKGKPMIIHVLNKVSAFCESKCSIVVINPDFEKEFREVLDENTLLAYQNSPKGTADALKRSLHLIPDNSDILVMYSDLVLIAKGSLKSLVELHRNGDCDITFLSGITQEKFPYALVERNENGKVVSFEERKIPDFPPPWEFYIGPIIIKKEIVQEYIGQLVPNKETGEIYIADIVALALSDNKSVCGFSTSHKEEFLGINTPEDLQTAEKLLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q3</accession>
    <name>I2F6Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731401.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1963"/>
    <dbReference type="EnsemblBacteria" id="AFK07606">
        <property type="protein sequence ID" value="AFK07606"/>
        <property type="gene ID" value="Theba_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1963"/>
    <dbReference type="eggNOG" id="ENOG5033Z0V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150806_0_0_0"/>
    <dbReference type="OrthoDB" id="1928601at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="26851" checksum="9CB30B37599FC6DF" modified="2012-07-11" version="1">MKIHVGGYGFQGLASIEYLGDFESESRMVLNGLAGYYVAAERAMGKKEALYRLSKFVDEFFVTLEVMDGGALSSKKRVSGKLERIRHCRIWSKSNHIYGIAARDSYLDGIAGKTELSAEVFNLETRKVELIRDDMREVAAACISIPGLFAPYNDVYVTTTYLSQIPVSFLSEGDTVILNLRDLSTDKPSTASEVVFRAMEIRSLNYAKIILANSSCVSVGVKTRVHSDNVFNYLDRVKRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W6</accession>
    <name>I2F6W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2026"/>
    <dbReference type="EnsemblBacteria" id="AFK07669">
        <property type="protein sequence ID" value="AFK07669"/>
        <property type="gene ID" value="Theba_2026"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2026"/>
    <dbReference type="HOGENOM" id="CLU_3329962_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="38" mass="4824" checksum="6F677E98394D83E5" modified="2012-07-11" version="1">MKEVRKMRGRERKVHYRERETYSNIIEDSIRSRVMNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z5</accession>
    <name>I2F6Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487937.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2060"/>
    <dbReference type="EnsemblBacteria" id="AFK07698">
        <property type="protein sequence ID" value="AFK07698"/>
        <property type="gene ID" value="Theba_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2060"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490788_0_0_0"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="241"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="565" mass="62489" checksum="40739B89EC0DE5F2" modified="2012-07-11" version="1" precursor="true">MSQRLDGKKVKSLIEMLSGYHRMRGSRDYKESMNSITDYLIRSGLPENRFRVLKYPADGVTKTGNIVSTLAWEPVYGELWLENPERVFVTSTKVTKVSLVSGSGSSKGWESLPLVVYDGKGDYSGKAVLASEDPVKVFQHAVVEGGARCLILCHMRKVFEEIGRSLNDLPQMTNFLTIPHDRDSADRNAVAFSVTKEKYDLLFNYSKKGSAIVGFRAETNMSKGSFDVLQIDATGFNDGPQVLITAHLCHPSPGADDNGSGAALAVEIARVLNDENFPYSVKIALVPEYLGSVPYALQLKSENNLPIYTINLDMVGADQNKTGSTFILSKVPPYLPQRWGNILEFYIKTLMPSNAGYPLKRFGEIPFMAGSDHCVFTTLGIPSPFMGHLPDRYYHSDLDTPQMMDEKELEWVGLSALNTLDQLVKPDQDLLISVRSKMIGELFGILNRISGREGSDDVFDLLISNYEGEVLRKVFNNSGNLPSLSPLEPTFDSSLGLEWIRTFPQELKDELEIDFASIADFVVGGAAVVGGREAVELLASIHYGVEIGKVRVLTGWMIEKGLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F714</accession>
    <name>I2F714_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731494.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2081"/>
    <dbReference type="EnsemblBacteria" id="AFK07717">
        <property type="protein sequence ID" value="AFK07717"/>
        <property type="gene ID" value="Theba_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2081"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_0"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="25"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="292" mass="30372" checksum="E61B3D0EC83386A2" modified="2012-07-11" version="1" precursor="true">MKKLLVITVFLVAASAFLFGATYRIGLSLSTLNNPFFVTLRDGALQAAAGLGVEVIVADGRDNPAKQLGDIEDFVQQKLDLIVINPTDSDAIVTAVEEANKAGIPVITVDRGASGGMVIAHIASDNVAGGMMAGEYVAMLLGGKGNVVELEGIVGTSAARDRGEGFGAAISKYPDIKIVAKQVANFNRAEGLVVMENILQANPNIDAVFAHNDEMALGAIEAIKAAGLLDKIKVVGFDAIDDAVAAVNAGEMAATVAQQPFLMGQLAVVKAFEYLTIGTIYIPVDLQLVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F793</accession>
    <name>I2F793_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2163"/>
    <dbReference type="EnsemblBacteria" id="AFK07796">
        <property type="protein sequence ID" value="AFK07796"/>
        <property type="gene ID" value="Theba_2163"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2163"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="246" mass="27508" checksum="B573510658C2ACD2" modified="2012-07-11" version="1">MNFRPLILGHRGMGTGEGENSLLSLIRAVQVGADGVELDVQLSKDGVLVVNHDSSLKRTLGVDVEIKDTTFRSLRKMKLVRPDGITTLERVYLELPEESFINVEIKDPLAADLVVPLVKSFNAIDRTLFSSFWHECLRKVKEKDEKAKIGLLIGEDARGKNPVEYFEELLAYHPYSINLPVQLFDEIGFELGMSLIRFVRAKGVKVALWTLNDPALLIKIRGEVDIIITDNLRGIMAALGGKGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A9</accession>
    <name>I2F7A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731577.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2179"/>
    <dbReference type="EnsemblBacteria" id="AFK07812">
        <property type="protein sequence ID" value="AFK07812"/>
        <property type="gene ID" value="Theba_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2179"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_6_2_0"/>
    <dbReference type="OrthoDB" id="2068669at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="45"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="114" mass="12756" checksum="284A03EA5DEADFAD" modified="2012-07-11" version="1">MFEFKKANDEIGVISLVKRARITGEMSANFRKWQETVDLKSCSTVIVDGNNIEFIDSMGIAALISIYKTVSAKGSDLILVNLSEEIKKLLNTLRLDRLFIIKNCSVVEAIKDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G3</accession>
    <name>I2F7G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731625.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2236"/>
    <dbReference type="EnsemblBacteria" id="AFK07866">
        <property type="protein sequence ID" value="AFK07866"/>
        <property type="gene ID" value="Theba_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2236"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="409" mass="46059" checksum="0966452FF0D9551E" modified="2012-07-11" version="1" precursor="true">MRKLMVLVLALVLAVGFSFGITITMMSPLTGADGAYMDEIVARFNEEHSDIEVVHVVVESSLDMKNKLSMGIASKTAPEIMFIRKFDMPLYLEHFKGFTKQEWLENYGIDTDDIFPGVLEGLVVDGKVVGIPMDIWLFYMAYNKGNFAKVGLDPNNPPKTREEFISAMEALLPITPEGLTPYYENPAWTWIWFHLLWQHGGEVLTDDFKAPAFEKAGIEVCKLMLEMQDKGILPMQVADPGVSFQSGESSVLITGIWTIKPWMEQLGEDFGYAVAPQLGNTKAVFGGSHVLAMPAVMVEDPKVLEAATTFIKYLWDHSIDWYEAGQTPARKSIAESEELKERLPHIYAVSQDSEYVRQFQMFPLISEIEAEIAVYLEEILVLHSMSPEAGMKEAAFAVQEILDDYWSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H6</accession>
    <name>I2F7H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731638.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2250"/>
    <dbReference type="EnsemblBacteria" id="AFK07879">
        <property type="protein sequence ID" value="AFK07879"/>
        <property type="gene ID" value="Theba_2250"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2250"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_4_0_0"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="247" mass="28229" checksum="F6605DBA227AC1AD" modified="2012-07-11" version="1">MARRKSLYEIIYSQIEREVQKMSDGTQLPSIEKLCEQYGASKTVLREVITALEKDGLVVRRQGLGTFVVKDSGLVHTGIEYLRGLTRIISSSGKSPELIYDKFREVKADRRLAEKLEMPENESLVLTERVYAADGIPAIFARTYIASERIPGKTEALLRTLEGRKAKELVLFDLLEENFKDPIRFAIAEIESRLVDEELAGLLEMRSGESIVLLKEVHRDIKNIPMLYSEDFINTSVFRIHVLRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H7</accession>
    <name>I2F7H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731639.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2251"/>
    <dbReference type="EnsemblBacteria" id="AFK07880">
        <property type="protein sequence ID" value="AFK07880"/>
        <property type="gene ID" value="Theba_2251"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2251"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_5_0"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="399" mass="43926" checksum="2206B425AB6D94FF" modified="2012-07-11" version="1" precursor="true">MVSKLTEIRTSEILKIIRERKSTSRVQISKLTGLSKPTISSIVNDLVEEGVVRENGLGQSKASGGRKPINISFAKDYRNVLSVDIGGTKTIFAMIDLDGNILKRDTITTDLLRTERGLVDELNERLKSYIEEVGKEKVLGISIGIPGTVDRTTQKIKYMPSFDIGNLDLKTPIEKRFGISTLIENDVTLSAFGESWIGSARQFNDVILVSIGTGIGSGIVINDSVYRGCVGGAGEIGEFVTDWSTESKMNEGFGRLEQWFSGYALESFCRNNGWEFSVKDLFEKMDSDERILERITGGCQHLALAFANAIMLLDPARLLIGGGIGFNQYDRIFPIIDSTLRKVLPKELYRPDLLVRAALEPYSVVIGGAYFAQKELLLKEVLGGTSGFLMQDTTRGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I8</accession>
    <name>I2F7I8_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731650.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2262"/>
    <dbReference type="EnsemblBacteria" id="AFK07891">
        <property type="protein sequence ID" value="AFK07891"/>
        <property type="gene ID" value="Theba_2262"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2262"/>
    <dbReference type="HOGENOM" id="CLU_2683579_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="74" mass="8127" checksum="664B4A836CA076C3" modified="2012-07-11" version="1">MSFRKNNVGNDKPLERGFRSRARKSRVWGLVRAEVMLGRTSQEVMPGVASGEVRLAARGSDAASQGATKRKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J0</accession>
    <name>I2F7J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2264"/>
    <dbReference type="EnsemblBacteria" id="AFK07893">
        <property type="protein sequence ID" value="AFK07893"/>
        <property type="gene ID" value="Theba_2264"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2264"/>
    <dbReference type="eggNOG" id="COG0834">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1508899_0_0_0"/>
    <dbReference type="OrthoDB" id="413371at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658585" evidence="2">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="45"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="178" mass="20062" checksum="F0909F330D7C1989" modified="2012-07-11" version="1" precursor="true">MKKLLVLLFVAVSTIMFLSSPCFAVDGKITLTEDEIIFVNEHPVIRLGVDPAFVPFEFIDKDGRYKGITADLLSLVSDRTGLRFEITPGLSWPEAYDLALSGEVDALPAISRTDERETLPFLRTLLLLQEGNRNQRHRQGYLRNRRPGRINSGCAKKQFSSQLLNILSEDKPESVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P3</accession>
    <name>I2F7P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731700.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2319"/>
    <dbReference type="EnsemblBacteria" id="AFK07946">
        <property type="protein sequence ID" value="AFK07946"/>
        <property type="gene ID" value="Theba_2319"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2319"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697925_0_0_0"/>
    <dbReference type="OrthoDB" id="2076707at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="395" mass="44501" checksum="D0597AB4FCCEE12C" modified="2012-07-11" version="1">MNYIELINNFWIANKIHKFNSLETSFYFFVLDYANNARWPESFVLPNGIVQSVFGCSRDQLIRARKKLCKFGLLAYETGDRHNPGKYTVIAHPTPTRDLPEADTRPTQDTPPCGLSKVSLNGQENCVIGDESISKTDSKPTGDLPEAYPTPTSNINKTKLKKSKVNKTGNKNILSPYGETKVSLSQSTGEGVKNEEISTGIEPESGVPEKGKTDPKEAPPCELNVSSSEIKSNGKETAQDKGGPPEVPAEGCLVVPLFEMNDPGEKQSEEDQEDFSYLESCSRYERDVMETWEAIIGPFEREWIPLLREALRKCYPSQIKTAIIAIDRSKHEVLEEIGFEYLMQPLLRGAFGRRVKKNGRKDWSDSEPFRDPIEKFKNPAREKPKTLEELLKYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T9</accession>
    <name>I2F7T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731738.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2372"/>
    <dbReference type="EnsemblBacteria" id="AFK07992">
        <property type="protein sequence ID" value="AFK07992"/>
        <property type="gene ID" value="Theba_2372"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2372"/>
    <dbReference type="eggNOG" id="COG5361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027269_1_1_0"/>
    <dbReference type="OrthoDB" id="547506at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1254" evidence="2">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="1">
        <location>
            <begin position="337"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="467" mass="52526" checksum="E2986563624F6521" modified="2012-07-11" version="1" precursor="true">MGMKNSLALISAILVFAVIIGAESTSVTSNYEEAREVARQAYIFAFPMLENYRTMVLQAVIPNSFNEFEHLQGLLGPEFREIARPNNDMLFSAAWLDLRNEPVIIEIPSICERYFSVQFIDMYTHNFAYAGTRTTGCRKLTVMISGPSCFVEIPNEIDEVFTSEGNFVFCKVRISVNPELEGDIDAVAKIQDSFKIRPYGAFCGSQTSSAVEPIAFPPFSQEKAESAGFISYLNFLLGQLEIHPSERALIERFSLIGIGPNLPFSENDLQPEMIIAIEKGIEDAMRIIFRPSEKMGVTKNGWNLTKRIFGSRQQMQGKYEIRAAAAYMGLYGNDLEEAYYPTSYVDADNEAYDGSKYDYRIHFESHEIPPTEPGGFWSITVYGDDEFMVPNPIDRYSIGNRSRLLYNDDGSLDIYIQHDSPGIDLESNWLPAPDGPFSLSLRMYLPSPGALDPLYCPPGVEKGRPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z1</accession>
    <name>I2F7Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <shortName evidence="4">Xylulokinase</shortName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylB</name>
        <name evidence="7" type="ORF">Theba_2429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731782.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2429"/>
    <dbReference type="EnsemblBacteria" id="AFK08044">
        <property type="protein sequence ID" value="AFK08044"/>
        <property type="gene ID" value="Theba_2429"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2429"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_2_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="258"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="503" mass="55758" checksum="160F8CF200ED062F" modified="2012-07-11" version="1">MRQGVLSIDLGTMGVKLSLVSLEGEIQKSAYTEYPIISESPGQAEQDSALWWEGIIDCVKKLTDSDNNLPHLIKAISICGQMHTHVYLDSEDKPIGPSITWLDQRSSEIIEEWQSDGRAARLFDLTWNFPTTTYAAPQICWVKKHRPGVFSRTKSILIAKDYIKFLLTGNKVTDPSDASGTAVFDIRTNQWSREALELIDLDGDLLPEVIPSARIIGHVTEKAARETGLIQGTPVVNGGSDHSVAELGSGLLGEGEVSCIVGTAGVVAACTSKPVIDPKKRIMCWSYPLEGYWDILGITQTAASSLTWFRNTFDKERNSEVFDEYSSLAKGVSLGSEGLVFLPYLMGERTPLWDYKARGVFFGLTMKHSKAHMVRAIMEGVSFSIKDCMKVVEELGVKFDSVNVMGGGSKSPIWRKIQSDVYGKKVRTLETQDTGAIGNLILALLATNEIGDPREAAKLIRHVETVIPDPIRAKKYENLFGIYKEIYENTRSIMEKLEAYTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F823</accession>
    <name>I2F823_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type proline/glycine betaine transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731808.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2465"/>
    <dbReference type="EnsemblBacteria" id="AFK08076">
        <property type="protein sequence ID" value="AFK08076"/>
        <property type="gene ID" value="Theba_2465"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2465"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_0_0"/>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="247" mass="26138" checksum="55BF8CF48ECEBAC1" modified="2012-07-11" version="1" precursor="true">MTGKNSRLSSWIFLGIFLLAFILLISNMALWENFLGWLFPEEREVLHPRGTLLELVAEHMWMVLVSSGLATIIGISIGVLVTRPMGRQYLPLVSNLSSLGQTFPPVAVLALAVPLLGFGFKPTVAALLLYGLLPIVRNTIAGIENIPPDVREAAYGMGMSSWQALFKVEFPLALKVIMSGIRISVVINIGTATVGATIGAGGLGSPIIAGLVAENPAFVLEGAIPAALLAFSVDAFLGNLEKTISSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D0</accession>
    <name>I2F8D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731900.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2583"/>
    <dbReference type="EnsemblBacteria" id="AFK08183">
        <property type="protein sequence ID" value="AFK08183"/>
        <property type="gene ID" value="Theba_2583"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2583"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_0"/>
    <dbReference type="OrthoDB" id="1756160at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="231" mass="26254" checksum="3C006534ED3A512D" modified="2012-07-11" version="1">MNRDIPFNRRFDNTLLNPESKWEDIESFVDDTLEYNFRNVVVPWYAIPTYVIEKVEGTEVGINVGPGGFPLGMVPTELKMREIEYYMSLGEAVTDFDIVINVSAVKSRNWDLMKREFVTLSERVKKGNRVCKFIIETSRLTEEEIVKVCELIVDVPTIDFVKTGTGFGPRATSYRDVELINSIVSGKKQIKVSGGVRTLEQVERFMKLGATVFGSSSSVSIYKEYEKKYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D7</accession>
    <name>I2F8D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-ribose pyranase</fullName>
            <ecNumber evidence="2 5">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsD</name>
        <name evidence="6" type="ORF">Theba_2590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RbsD / FucU family. RbsD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2 5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731906.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2590"/>
    <dbReference type="EnsemblBacteria" id="AFK08190">
        <property type="protein sequence ID" value="AFK08190"/>
        <property type="gene ID" value="Theba_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2590"/>
    <dbReference type="eggNOG" id="COG1869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135498_0_0_0"/>
    <dbReference type="OrthoDB" id="1750843at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01661">
        <property type="entry name" value="D_rib_pyranase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="133" mass="14613" checksum="80CE045F1A3C55B5" modified="2012-07-11" version="1">MKKSGILNKEICNLIGSMGHTDLLVISDSGLPIASDRYRIDVSIVGGKPGVFDVLDPVLEELEVEKVIFSEEMKTVSPKCLEETLKHLPEGIEVEFVPHVKFKELTNTQSKGVIRTGEQIPYSSIILVGGVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K2</accession>
    <name>I2F8K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487256.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2655"/>
    <dbReference type="EnsemblBacteria" id="AFK08255">
        <property type="protein sequence ID" value="AFK08255"/>
        <property type="gene ID" value="Theba_2655"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2655"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760328_0_0_0"/>
    <dbReference type="OrthoDB" id="1485504at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="364" mass="40743" checksum="691EF58E573C0622" modified="2012-07-11" version="1">MKRRLPGDKLIWRALRPILRVPFIKRYNLYGIGMEKLPRPPFILIGNHAYFIDAVLIEALTSFPIVWAVAAGNFDNPFSGPILRAAGAIQKRKGVPDIPAMRKMIEVVSNGGVLGLMPEGSVTWDGEFGEVPPGTDRFLERLDVPVVAARMSGAYLTKPRWADHHRWGRIEVEFKSFAGKEALDFLSEASDWRWQEEKKVMFKGRNKAEGIEKIIWFCEKCGEFQTVKASGDSAICDKCGTSLTVDDYGLVSGRTVPEIIGIQREILAEHIALNGGIEVGEGTVTEMEIGSGAKTSYAGRVSMNSRELRIGERSYLLPKIRGLSNFLKRITEFNYEHSIVRLMTGSSSLLLFWAHRYFSHPHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L7</accession>
    <name>I2F8L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731966.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2671"/>
    <dbReference type="EnsemblBacteria" id="AFK08270">
        <property type="protein sequence ID" value="AFK08270"/>
        <property type="gene ID" value="Theba_2671"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2671"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_3_0"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="452" mass="50404" checksum="3B56FC41B203EE3A" modified="2012-07-11" version="1">MKTVLKNIDYLVTMNEKREELKDAYVVVEDGIIIDVGKGTPPPGDVEIDLAGRIITPGFVNTHHHFYQSLFRSVKEVASAKLFDWLVFLYERWKNLDNEAIYVSSKVAIYEMMMSGVTTTTDMLYLHPKGRSEFIDSEIEAARSTGVRFHPTRGSMSLSRKDGGLPPDTVVQSEREIIEDSVRLIEKYHDREKHSMLRIALAPCSPFSVTEESMVRTAELAGQYDVLLHTHLAETRDEDDFCIEKKGLRPVDFMEKVGWLNERSWFAHLVWLSDEDIKKLAGHDCGMAHCPSSNMRLGSGIARVKEMKEAGMRIGLAVDGSSSNDTGNMLLEIRNALMLQRVLKGADALTPRDVLEFATLGGARVLRMDDFIGSVEVGKSADLAAFRLDTLSMSGGLSDPVASLVLCDPHKSDMVMINGKIRVQNGRVIDSELPGLIKRHNEISSKLIGGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R6</accession>
    <name>I2F8R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732012.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08319">
        <property type="protein sequence ID" value="AFK08319"/>
        <property type="gene ID" value="Theba_2724"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2724"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48682" checksum="9AB4069BECAFB1C9" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWRYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLELHPEKTRIVYCKDDKRKDEYPNTSFDFLGYTFRVRSCKDRNGRIFYGFNPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRKFEMYTVLSRLHKALVQWVRNKYKKRRGRTKAGKWLEALARREPHLFVHWTMGIFYSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R7</accession>
    <name>I2F8R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732013.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2725"/>
    <dbReference type="EnsemblBacteria" id="AFK08320">
        <property type="protein sequence ID" value="AFK08320"/>
        <property type="gene ID" value="Theba_2725"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2725"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="35191" checksum="4EEF3926240B3DC0" modified="2012-07-11" version="1">MKRATLREVAKKAGTSMMTVSRVINSKDSVRDETRNRVLRAISELGYEPHKDARILRGGKTGRIGIVVSDIRNPFYSQVVGDLEDLAEENNMAIIVSDTSKKLNQERKAIKSLLDIKVDAILVAPEGYESSHLIDVINSGTEVVSFGVHFENDEISEVSIDEITGAAKAGAYLKSVGISDVVMMMGNPRKFTTRGRMEGFMRGFGHVPEDRVIYCEVDWKASCATVSEMQRLPQAFFCYNDMMALGVMKALEERGVELGSEVKVIGYDDVYMAEIAGITTLRIPIRSMVKEAFKTILGDEVRKMVFTPEFIRRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G0</accession>
    <name>I2F1G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729946.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0008"/>
    <dbReference type="EnsemblBacteria" id="AFK05763">
        <property type="protein sequence ID" value="AFK05763"/>
        <property type="gene ID" value="Theba_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0008"/>
    <dbReference type="eggNOG" id="ENOG503420P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459528_0_0_0"/>
    <dbReference type="OrthoDB" id="1523735at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="21172" checksum="BE9CDD9D62269D01" modified="2012-07-11" version="1" precursor="true">MKSLALVAFLFFGMTVFCFTSTFVSWEMPELEEYKGLLERLVGKPVTGTYRLIIASSTGEFMELSGLGYWFIAAAEDSTIFVQPLSLVPNVTQTVAHEMCHLFLRQYRLPYWLEEGIVCCVTGEWIGRKELILDRVESLDYSGMDFMTYRSYSFSCWVEVSKILRERTFGELVVALGEGVDEQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L9</accession>
    <name>I2F1L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729995.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0071"/>
    <dbReference type="EnsemblBacteria" id="AFK05822">
        <property type="protein sequence ID" value="AFK05822"/>
        <property type="gene ID" value="Theba_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0071"/>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024057_1_1_0"/>
    <dbReference type="OrthoDB" id="1309809at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="414" mass="47235" checksum="576698F30929ED12" modified="2012-07-11" version="1" precursor="true">MLIALIILSIVTLISFLFVIASVRRLSRSIKKNQELQLSLKDLERDVSDRDEKLKWLTSAKEELESTFKAISSDVLNSSTENFIRQANDKFSGLLKLQKEDWGSQKKDFESLVSPVRDNLEKLEKNVKELESKREGAYKALEEQLKMLSEANTDLRQGVTDLKSALRNRSTRGRWGEIELRRIVELSGMTEHVDFVEQESIDNGRPDMIVKLPNNAFIPVDAKVPLDSYLTALEEEDESLRKQLMGNYAKNVRDTVNRLAGKKYSEAFSRTADFVVMFVPLESAINAAFLADPELFEYAVSRKILIASPVNLVALLKSVAYGWQQYSLTENAERLVQASKELYERFRVFFSHYSRLQGHLKNAVKAYNDGVGSFESRLLPKVREIEALAEVKEKLEEIEEISDEPRSTNLAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N3</accession>
    <name>I2F1N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC-type transport system, periplasmic component/surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730009.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0086"/>
    <dbReference type="EnsemblBacteria" id="AFK05836">
        <property type="protein sequence ID" value="AFK05836"/>
        <property type="gene ID" value="Theba_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0086"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_2_0_0"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="2">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="349" mass="38997" checksum="807EBB6C5F78BA0E" modified="2012-07-11" version="1" precursor="true">MKGIITVLFILCAVILASEPFSIGFIYVGSVNDGGWTEKHDEGRLYLEKTFGSQIETSFIENVTEGEQDLEVLRSYAERNVKLLFSTSFGFMDDVLEIAKDYPDTIFMHCSGYETAENVGTYFGRIYEPAYLTGLIAGKMTKSNIIGYVATFKIPEVIRGINAFANGIGKVNPDARVHVIWTETWFDPSSEEEAADALLDLGADVIAQSQDSPAAVQAAGQRGVYAIGYNTDMSAFSPDTFLTSPIWNWGVFYERVVKEVMEGKWTSYQYWGGIEDGVVDIVMSNLVPADLQELMNKERSRIIEDDYHPFEGPLQDQDGKLRYSEGEEPTDEELLTMDWFVSNVIGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R8</accession>
    <name>I2F1R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05871">
        <property type="protein sequence ID" value="AFK05871"/>
        <property type="gene ID" value="Theba_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0123"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_0"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="71"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="299"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="448" mass="52551" checksum="0C6F22AC9FACC01B" modified="2012-07-11" version="1">MEFFDREDEMAFFEGLTKRKSKKMVALFGRRRIGKTALLKKVYPNARYFFVDTRSSETLLKDFSSQIFEGSFDNWEGFFRALFRLQEVVIFDEFQNFMRVDQSVFSILQKVWDENSGRSLLILCGSYVGMMKRIFLDQKAPLFGRCDHKVELKQFRFRDALEMIRSFGYSFEEAVEWYSILGGIPQYLWLLEEKASFDKKIRELFFDRFAPLREEGKNLLIGEFGTEHPGYFSILEAVGYFDRDVGEIVDRTGMERTKAMKYLSELTNNYGIIGKVENLLSKSKRGLRYTIKDNFLSFWMKYIYSRQNTVEFDSEQALSYTIENLGEYIGRAFESIVKSLIPDLYRAEKIPLLPERVGKHWGKIPGTRNKTYEIDLIGESRDRILVFECKWRKDPVGPEVAEELIEKMQYIPDKRIKVPVVISKSGFKANIPKEVLLIDLRDLEESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S7</accession>
    <name>I2F1S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730045.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0134"/>
    <dbReference type="EnsemblBacteria" id="AFK05880">
        <property type="protein sequence ID" value="AFK05880"/>
        <property type="gene ID" value="Theba_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0134"/>
    <dbReference type="HOGENOM" id="CLU_1553456_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="172" mass="19438" checksum="8B112F7D5FB1129A" modified="2012-07-11" version="1">MNNYTVIREEPDSERNLELLLEETERIFYYQLELSDKLDAKATSFILFYSILFGAEAIIVSTFYEMMKSTYLLSMHLLASSVILSFLGLFFAVLGLRPKVFAISMISRAEIDCTASKSYDDLCKHLIAYYVDKVQPNKLSNDKKASCLSISSLLGVLNLSVLASFLVVIIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T8</accession>
    <name>I2F1T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730056.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0149"/>
    <dbReference type="EnsemblBacteria" id="AFK05891">
        <property type="protein sequence ID" value="AFK05891"/>
        <property type="gene ID" value="Theba_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0149"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_0"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="288" mass="32472" checksum="C47F81FB939C8900" modified="2012-07-11" version="1" precursor="true">MSKLAREEKTAFKMVLPYLLIIVLLFVYLIGSNIYSSFTTEEGAFTLQNYSSVFTDPVVGRSMINTVVWVIGSVLGQLLLGLLVALLLNESTKGQIIFRSIILILPWATLDIVAGVMWKWMYNDMYGVLNDVLVKMNIINDYIPWLATENMAMISVIIANIWKGFCLSGMFFLAGLQTIPPDLYEAAEIDGANSIRRFWRITIPQLKPVIMTTLMLTVIWTINYFPLIYIMTGGGPGYGTETVVTYIYKLGFRFLEFNKAAALSNILFVAIFAIAFVFLRSIAKEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F224</accession>
    <name>I2F224_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterial nucleoid DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491697.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0243"/>
    <dbReference type="EnsemblBacteria" id="AFK05977">
        <property type="protein sequence ID" value="AFK05977"/>
        <property type="gene ID" value="Theba_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0243"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_0_0"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="90" mass="9804" checksum="D0E045C2624DB698" modified="2012-07-11" version="1">MNKKELIAEIAEKTGVTKKDAGKTLDTVIDIIEKTLSKGDVVRLVGFGTFMVASRKARKGVNPRTKKPITIPGGKVPKFVPGKELKEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F253</accession>
    <name>I2F253_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">Theba_0274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491740.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0274"/>
    <dbReference type="EnsemblBacteria" id="AFK06006">
        <property type="protein sequence ID" value="AFK06006"/>
        <property type="gene ID" value="Theba_0274"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0274"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_3_0"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="67" mass="7479" checksum="40AF447BA910753D" modified="2012-07-11" version="1">MGNKVKMKTHKASAKRYKVTGSGKIMRNQSGTGHNTGKKSESSRREARKWKLVEGGYEKKVKKSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D1</accession>
    <name>I2F2D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0355"/>
    <dbReference type="EnsemblBacteria" id="AFK06084">
        <property type="protein sequence ID" value="AFK06084"/>
        <property type="gene ID" value="Theba_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0355"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_0"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="291"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="455" mass="51544" checksum="A35F24837880D217" modified="2012-07-11" version="1" precursor="true">MEDPTSSGDPVSILLNLLLLGFLLYLSGVFSGTETALMSMGKLKLRDLVDSKEKRFSKSVKFFVQNPNSVLTAILVMNNVVNILSSSLATLLALQVLPDNSAGVAAALVTGIMTFLILIFGEITPKIYARENSERLFRRTITFISAITIVLKPILWLLLRISSFFIVIIGGKKAEFAPFITEDEIKSAVDAGHKEGVLQSEERMIMKRTLELKDISVKEIMTPRVEIVALEEEQPLIDLMELVQSEGYSRYPIYRENIDRIVGVCYAKDLLNFILDRKDNDVLQTIRVEEIMRYPYFVPETKKVDDLLREFKEKKNHLAVVIDEYGGTAGIITMEDVIEELTGEILDEYDEESEEIMIERLGEREYIVDGMTPINDIERELEQPFPETEFETIGGYLLEVLERFPEVGEKIIVDGFTFEVLAAGKNKVEKIRLIVDRRSVDDRQIGGEGTNTESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D8</accession>
    <name>I2F2D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC-type transport system, periplasmic component/surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491942.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0362"/>
    <dbReference type="EnsemblBacteria" id="AFK06091">
        <property type="protein sequence ID" value="AFK06091"/>
        <property type="gene ID" value="Theba_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0362"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_0"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="340" mass="36626" checksum="C716BBDA72437D0A" modified="2012-07-11" version="1" precursor="true">MKLKLLLVFSLILMFALPVLAMKVIMVTDVGGLGDKSFNDGTWEGIVKASDFLGLEREVVQSKEQADYIPNLSNAAKEADIVFGVGFMMADALYKVAPQFPDTYFIGIDIDPIENMPNNVATYLFKEQEGAFLVGYVVAAMTKTNMVGFVGGLPIPPVERFRYGYEAGIRVYEELHGKTISILQGYTMDFNDPKKGKDLAIAQFAEGADIVFHAAGACGNGVIEAAAEKGEGFFAVGVDVDQDYMAPGRVLTSSVKRVDMASYQAVMSIALGTFEPGAKTLGIKDEGVGISPMTYTKDIVGPTILSQVEFLKGLIKAGTLVVPDTQEKLDAFVVPEITLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S1</accession>
    <name>I2F2S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730331.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0498"/>
    <dbReference type="EnsemblBacteria" id="AFK06224">
        <property type="protein sequence ID" value="AFK06224"/>
        <property type="gene ID" value="Theba_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0498"/>
    <dbReference type="HOGENOM" id="CLU_1650140_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="160" mass="18578" checksum="00A464CD8C83E044" modified="2012-07-11" version="1">MSKKEFLKRILSEGRSADEIADLFGITAERLENYLEDPSRSKLAVAEIKTELRRLESLPLETKEDILLFSFRVILESINFLFSDIERAASDKREERLPCLIRKLIDGAYLLLAISRLEKVGKNLSSMKFDERFLRACQNKALVVDRLMDLAELIDREIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T4</accession>
    <name>I2F2T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730344.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0514"/>
    <dbReference type="EnsemblBacteria" id="AFK06237">
        <property type="protein sequence ID" value="AFK06237"/>
        <property type="gene ID" value="Theba_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0514"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_0"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="337" mass="36656" checksum="9C5AAA18C65B2618" modified="2012-07-11" version="1">MNLARLLVDLSNAFGPVGYESEVHSVIKEAIDPFVDETYTDEIGNLIAVKKGDKKRIGVFTHVDEVSLVISKIDERGFARFEELGGIDPKVLISQKVKIKCRDGEERAGVIGMLAPHLQKKETRGEVPSFDELFIDASINPDFEKIDVGDLAVVDFSAFEMNGKVSGKALDDRACAAISIETARELSKYSLTPTVYFVFTTREEVGAIGAKGAAEALELDLGVAMDVTHHNKENDVELGKGPALTVGGPNIHKKYFELLNNYAKDNEIKVQYEFGSGRTGTDADNVQIAGTGIPTLLLSLPEMHMHTPVEVVQISDIASTARLLAGFFVSLKGDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T9</accession>
    <name>I2F2T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730349.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0519"/>
    <dbReference type="EnsemblBacteria" id="AFK06242">
        <property type="protein sequence ID" value="AFK06242"/>
        <property type="gene ID" value="Theba_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0519"/>
    <dbReference type="eggNOG" id="ENOG50331P7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128031_0_0_0"/>
    <dbReference type="OrthoDB" id="1680138at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="2">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="246" mass="27467" checksum="296ABC10663D3A58" modified="2012-07-11" version="1" precursor="true">MSEESHDYVLKTLIVVVLGLSAIVFILGGYAILLREENRRAKLVIEEIRSSVFTPSTDQPEVSENPVEIPTGTQIIREAISVPETQNFFLETFDYRRLITNSFDFLAEGSEFGYVVVEEGTAFKLCVEKGLGKYFITRVGDQFGVMFLGENPLTGLYDSKTAYGIQLVSHTVSDGIAPQVMDLRSAGYPAFVYKSITTDGRTFYAAILGVFPDANAARNYSSEVDVQSLQRITGWNITDRFPRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U1</accession>
    <name>I2F2U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxyqueuosine reductase QueH</fullName>
            <ecNumber evidence="5">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Queuosine biosynthesis protein QueH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the QueH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730351.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0521"/>
    <dbReference type="EnsemblBacteria" id="AFK06244">
        <property type="protein sequence ID" value="AFK06244"/>
        <property type="gene ID" value="Theba_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0521"/>
    <dbReference type="eggNOG" id="COG1636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088177_1_1_0"/>
    <dbReference type="OrthoDB" id="1078220at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="PTHR36701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="260" mass="30134" checksum="EF73E900F6A12E1D" modified="2012-07-11" version="1">MNVLHVCCAPDLVSTVFKMEELRDSKFFFYNPNIFPEEEFFRRYKAFKEVCESLSVVCPEPSYHPEDFSKILDSYVDEKEGGIRCSKCIELRLKKTAEMAKSIGAESFSTTLLASPRKSVKLITLIGDKIANDLSIEFISGNFRVDRGKLNTLIRGIYKQDYCGCQASLSEKEKEREIRDARDRERLERDFGDLVDLWRFRGEVVLRSEIPVNDISELKKLIGIIKPATLFDDLEDAELKNKRWLKTGTYNCRILKEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y2</accession>
    <name>I2F2Y2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730382.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0563"/>
    <dbReference type="EnsemblBacteria" id="AFK06285">
        <property type="protein sequence ID" value="AFK06285"/>
        <property type="gene ID" value="Theba_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0563"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097916_1_1_0"/>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="176" mass="20462" checksum="B87689DDA52585DD" modified="2012-07-11" version="1" precursor="true">MTKDLFLGFGSNMGERLNLIIKAFSMLIERGITLQSVSSLYLTEPLGIIEQNEFLNCVGKFEFKGDPHFLLEEIKAIERSIGRVERFRWGPREIDIDILLFGEMILTTDKLSIPHKDIIRRKFVLVPLLEIDEELRDPRDNSLFSDHLESLGKEGWPELFLEAVLFEKLIELEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F315</accession>
    <name>I2F315_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0599"/>
    <dbReference type="EnsemblBacteria" id="AFK06318">
        <property type="protein sequence ID" value="AFK06318"/>
        <property type="gene ID" value="Theba_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0599"/>
    <dbReference type="HOGENOM" id="CLU_3292250_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="40" mass="4820" checksum="BDD7EA1DD6631E27" modified="2012-07-11" version="1">MTKKGLNLFIERAMVYSNEKVINKQLIILSKKRWNSVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F330</accession>
    <name>I2F330_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730411.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0614"/>
    <dbReference type="EnsemblBacteria" id="AFK06333">
        <property type="protein sequence ID" value="AFK06333"/>
        <property type="gene ID" value="Theba_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0614"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_0"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="340" mass="37400" checksum="D5C5D39237E71AA9" modified="2012-07-11" version="1">MSRVVTFGEIMMRLASPLGERFEQTKNFEVVYGGAEANVAVAIAKYGGKSRFVSKVSADQFGDAAIGNIGVHGVDTNYVLKDIGRLGKYFYEYGYSQRPSKVIYDRDNSVFANSKPGDFDWEEVFSDATWFHFTGITPALSDGLIETCEVALREAKKRGITVSCDLNYRSRLWSKEKARKVMTSLMNNIDVLFANEEDSESVFGIKAEGTNVSDGRLSVEGYRDVATKLRDTFDLKAVAISLRESINANFNKWSAALLTGGEFIVSTKYDINIIDRVGGGDAFAAGLIFGLDNSWEPLKSLEFGVAASCLKHTIKGDFNIVSRDEVEKLLGGNASGRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F333</accession>
    <name>I2F333_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730414.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0618"/>
    <dbReference type="EnsemblBacteria" id="AFK06336">
        <property type="protein sequence ID" value="AFK06336"/>
        <property type="gene ID" value="Theba_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0618"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_1_2_0"/>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="92"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="28115" checksum="BA9612629E47BBE0" modified="2012-07-11" version="1">MKEQIAYCCKKLRLGRKIVDVFEEVEADNNQEYLMKILQIALDNRETSRKNRLVKQAGFYAMKTFEDFSFEEIRLPQDLSPEELKKASFVDEKKNLILYGNVGTGKTHLAQAIGLEACKQNKVVRFFRTAALVNRLSEAQKKSELNAFMKTLMKADLIICDEWGYVPLDRDGSKLLFQVISECYEQRSVIITTNLEFSKWVHIFYDEQMTSAMIDRLVHHSHLLLFEGQSFRIRNSLMKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F336</accession>
    <name>I2F336_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730417.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0621"/>
    <dbReference type="EnsemblBacteria" id="AFK06339">
        <property type="protein sequence ID" value="AFK06339"/>
        <property type="gene ID" value="Theba_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0621"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358180_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="248"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="647"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="782" mass="87898" checksum="D2B45DC63CC48E1C" modified="2012-07-11" version="1">MESDRRNLFSSVRRIISVLVGNEKSLQKIKKALSIIGDSLSVNSLTFCTVESAHHSSSYIKMVCDWRKESDSVICVSSSRSGDSRKSKLENLIRKSRANTVSEAGKGVLLIKSPPGLPECVLVLEIELHERNLSVEEKDFVKCAIQLLALMTGEEFSEETGNNEKSLLQERLLRSDELLKNFEGNVLDILAVVDGGLVFTYVSPSVVNTLEFMPEDLVGKNALDLIDSRDRKRVVEESKVLLREKKHGCFRYRARTKSGGILWMETAVSPLFNGKEVEGWTMSSRDVTGEMKLQAELKARDSMMVFMNDLYVLILSGDNLHEAASKIVNRAYEEKGMVGCKITFSEDEYLDLEVSRGDTEAFPLNLMKDSKAQETLRENRIIVQNTAIEGKELRYICIALESNNEIAGYFETLTERVTGLSEESINLYRLVGTTVSLSLTKIKNLVATRRNHITSQSLIKATEAITKDLNMRTVIESIVRGLRQVIPFYSAAVELVEGDHLIIVGGSWPGKNSFVGTKFTMEEGSPGFDVVRNKKIILAEDAQRAYQQFNRPDFKFIKSWMGVPLVIGDETIGMIAVDSEEGGKFKNRHLDALKAFADIAAIGINNARLHEEVRDLSVRDYLTGAYNRRGLFEHGEREIEKAKRYDTKMGLIMFDIDNFKNMNDMLGHLAGDFVLKRVANICTKILRAADIFARYGGDEFIILLPMTDITNTEEAATRICRSLEDSRIIYKRIPIKVRASFGIANFEGHEDELEDMIRRADRNLYVSKRSGGNKVTGGRNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F347</accession>
    <name>I2F347_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730427.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0632"/>
    <dbReference type="EnsemblBacteria" id="AFK06350">
        <property type="protein sequence ID" value="AFK06350"/>
        <property type="gene ID" value="Theba_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0632"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_8_1_0"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="239" mass="27633" checksum="90FBFC9ACB3BB510" modified="2012-07-11" version="1">MEHIINRIRYADRILEVGCGTADYLSILSELLYAHGFGFDTSPSMISEASKKNQRIELELATADKNGPFPYGNSEFDFVFNINLVHYISDLENLFKESFRVLQNDGSILTVTDSCKDISERTLTNYFPETLDIDRGRYPGNSSIISAMKKAGFEGIYTTKMKTPFEFKKQHFEQYRNKAYSSLRLIPEERFEEGIKRPESDMERGLVLGKKAYTQIWDIKIAKRDFDLPMIYTTSFTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F378</accession>
    <name>I2F378_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">Theba_0664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0664"/>
    <dbReference type="EnsemblBacteria" id="AFK06381">
        <property type="protein sequence ID" value="AFK06381"/>
        <property type="gene ID" value="Theba_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0664"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="28891" checksum="D9CA9347ABF01921" modified="2012-07-11" version="1">MIMKRFAAIVSYDGTDFFGFQNQPGLRTVQGKFEEALHRIHKFCISSQGAGRTDTGVHGFGQVIAFDSNLDRLEATTMRDALNANLPSDMYVRKVHEVDENFSPRFAAKKRIYHYYIQTSSEPDIFRRRFVWWFPYSLDIKSMRRAAVNLLGEHDFAAFRTGKDDRNPVRTITAIRIIRYKPYIILIRVEGISFLKRMVRNIVGTLVKVGTGSVSEESVSEFLSSHDRSTLPGTAPPQGLVFYKVIFDEFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E1</accession>
    <name>I2F3E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00255 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730502.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0727"/>
    <dbReference type="EnsemblBacteria" id="AFK06444">
        <property type="protein sequence ID" value="AFK06444"/>
        <property type="gene ID" value="Theba_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0727"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076609_1_0_0"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="206"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="33134" checksum="9990C83E59B4E1D8" modified="2012-07-11" version="1">MLRSMTGFARVEKTVREVNVFVELKTVNSKYLNVDVNIGDAFSELEMNVTRVIKENLKRGTVRARIDISLVNSDDLLQPDFGIASSVYNSLKSIKERFELAGDVTVDSMARFKEIMRSKPSEDLAKKIWSVIEELLMEAISVLNSDREREGENLASALNEYLCELESIGRELQDSSKDMVLYYRDFLKKKVEQISDSQLDDNRLEQEVALLAERADISEEIVRLISHIESFREVMASEKESGVQLDFICQEMHRELSTIASKSKKLAITNLSVEGRTLVNKIREQVQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F3</accession>
    <name>I2F3F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="11" type="ORF">Theba_0741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730510.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0741"/>
    <dbReference type="EnsemblBacteria" id="AFK06456">
        <property type="protein sequence ID" value="AFK06456"/>
        <property type="gene ID" value="Theba_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0741"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_0"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="384"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="974"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1564" mass="176733" checksum="CCD16569408B87C8" modified="2012-07-11" version="1">MPVSTYKRKVNKLEIDIASPERIRSWSSGEVKKPETINYRTFKPERDGLFCEKIFGPTKDYECTCGKYKGKKYEGTVCERCSVRVESKEARRRRMGHIELAAPVTHVWYLKSAPSVLSSLLNIPAKDLENIIYYGSKRVIERLYVVTDPKDTDFFPGMTMYQTEYEIYTKKLSFEVEQGYKVKAPHGPVTTDIDGKVRIERLDSSTERELNWVVVTNETGIEKKYPVFEGSLIYVQNDDEVHKGDTLADRFLFEDEVLSATEYKIFDEYYPGKFEVETDTESDRPIVIITEIDPTVSEETGRSIGEVLIENEYEAYKELYPGKVTCDYGAAAIKKLLQSIDLEELQVAIEHELKTIPKSSARALKLLRRLKYVKDFIASSNKPEWMVMDVVPVIPPDLRPMIQIEGGRFATTDLNDLYRRVINRNNRLAKLLQIGAPDIIIRNEKRMLQEAVDSLIYNGRVGKAVSDKSGRPLKSLTDLVKGKKGRFRRNLLGKRVDYSGRAVIVVGPDLKIHECGIPKRVAMELFKPFVLSKLLHGSESSKTARKLKKTIIEKEMPEAWEVLEDVIKGHPVLLNRAPTLHRISIQAFIPRLVEGNAIQLHPLVCAPFNADFDGDQMAVHVPLSAAAQAEAKFLMLSRYNVISPASGKPISMPGKDIIVGVYYLTTVDHEYEKKEKEIMDYDARLREDEKISEVEARRKVREKALEWVDWKFSSAGEALLAYDSGYISLHDPILVQLDPSSGELTLTTVGRIIFNTIVPEKLRDYMKKFNKKAIKKLIYDCFHEYGIDRTADLLDDMMSLGFHYATTSGLTISINDIVVYPQKDKVIEAAQERVDQIENLYKSGFLTEEGRTEEIIRIWSDTTQEIMEKTYTEFEKYPFNPIYMMVDSGARGNIDQLKQLAGMRGLMADPSGKTIEVPIKSNFRDGLTELEFFTSTHGARKGSADTALRTSFAGYLTRRLVDVSQTITVTTPNCGTHEGIEAVELMADGVTIEKLEEFLFGRVLAADVINPLTGKVLKNEKTGKEYFRDTMIRDEDAAFLSGYKAKVEVAREEVLSIAKVTRLINYTELDEDIKINDKEYKKGTHIGSDLLHQLKNSEIEEIKVVAFPCVNQIFVGDPIKNDSKEMLVKYQEKIDELTAKNLQKNEIEKVFVRPTIKVRSVLTCESDNGVCAMCYGMDLSNHEIVNVGESVGVVAAQSIGEPGTQLTMRTFHTGGIATGQDITRGLPRAEELFEARKKLKDPEALFIEKGDGGFVKDLVSDDKGRRKVYIETKTGGISEYDLSSNIKPKIEIGDKVTEGEAITTGTVRPRKLMEKLGLVQTALYLLTEIKRVYAEQGVEIHDKHFELIIRQMLSKVEVTDPGDTDFLPGDLLDIVEIRKINKSIEEANSRVGENREYVIGKRLARRVLGEDEDGKIQKIAAEAEPISEELLEKILKGGIKQILIYDVDEDHYQKLVDDFNPDTVIPEKNIQIMPKDPIKFKRKLLRITKASLESEGWLSAASFQQTPQILTEASVAGKSDFLQGLKENVIVGQLIPAGTGLDMYANLQVEEAVVPSQYQEEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H3</accession>
    <name>I2F3H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730530.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0762"/>
    <dbReference type="EnsemblBacteria" id="AFK06476">
        <property type="protein sequence ID" value="AFK06476"/>
        <property type="gene ID" value="Theba_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0762"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_0"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="252"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="486" mass="54419" checksum="942712CD02E25EB7" modified="2012-07-11" version="1">MNYILAIDQGTSSSKAVLFDHELYQVAVAQEEFKQIYPKPGWVEHDPRDIILSTMSTIERVVSDARISFREIAAIGITNQRETVVAWDALTDQPLYNAIVWQDRRTAGRCKEIESSYGELIRRKTGLKPDPYFSATKMEWLLENVPAVRDAANRGRLRFGTIDSWLVWNLTRENLHVCDFSNASRTMLFNIEELKWDNDLLNLFGVKEEYLPTVVESCKLLGPSIYGPRIGGMAGDQQASLFGQTAFQTGDAKCTYGTGSFILMNTGKKPKISEHGLLTTIGWKSKEEIVYAVEGSIFATGALISWLKDGLGIIDSPSETESLAREVADNGGVFFSGALTGLGAPYWNSSARGMMIGLTRGTRKAHIVRAVLEYIAFRTREILDLMEEETGIRLNKLLVDGGVTRNNFLMEMQANVLNIPVDRSLIKETTALGAAMLAGICTGLWDLESLKNKRISEVVFEPSGDRMEEEFRRWKEALKRSMNWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H8</accession>
    <name>I2F3H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730535.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0767"/>
    <dbReference type="EnsemblBacteria" id="AFK06481">
        <property type="protein sequence ID" value="AFK06481"/>
        <property type="gene ID" value="Theba_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0767"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="47962" checksum="BA01536E2DBCB912" modified="2012-07-11" version="1">MLSFPDGFMWGVATAGHQIEGANVFSDWYAWEHQGKVKNGDTSDVACGSWEHLERDLEAIKALGVNAYRFSVEWARIEPKVNRFEDSVIERYKDFVTMLIENGVQPILTLNHFVLPQWFSEIGGWEDRENLPYFRRFVSRIVSSMGENIHYWVTINEPNVYAVMSYLMGEWPPEIKDMGRAMRVLANLLYAHSEAYDVIKESNPLSMVGVAVNMMPFFPLRTFHPGDRIVSKYLDRVYNYSFLDSLKNGKMIRPLGTGEAVSGISSKLDYLGINYYTRMFAKYAKPLPEIVVGDEFEKTEMGYEFFPQGIEDLVLKAYNRYELPIMITENGIADGTDKRRWEYIETALKSLRDAMDKGARVFGYIYWSLMDNFEWKEGYSMKFGLYETVRENLELRPRGSADKFRDFIRESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J3</accession>
    <name>I2F3J3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="3 6">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PduL family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730550.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0782"/>
    <dbReference type="EnsemblBacteria" id="AFK06496">
        <property type="protein sequence ID" value="AFK06496"/>
        <property type="gene ID" value="Theba_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0782"/>
    <dbReference type="eggNOG" id="COG4869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080676_1_0_0"/>
    <dbReference type="OrthoDB" id="1156172at2"/>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="197" mass="21211" checksum="04615934DDA4D27C" modified="2012-07-11" version="1">MKLKQPAIKTGVSNRHLHLSAADIESLFGKGHELTPVKDLGQPGQFACDEKVILVGPKGAITGVRVLGPARKATQIEVSRTDSFTLGIKPPIKDSGDHTDTPGLTIVGPKGTVVLNSGVMLAKRHIHMTPEDAEIFGVKDKDIVMVYAKGSGTRKVVFDDVLVRVHSSYALEFHVDVDEANAAILNNDDPVYIVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K2</accession>
    <name>I2F3K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-asparaginase/GlutRNAGln amidotransferase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730558.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0791"/>
    <dbReference type="EnsemblBacteria" id="AFK06505">
        <property type="protein sequence ID" value="AFK06505"/>
        <property type="gene ID" value="Theba_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0791"/>
    <dbReference type="eggNOG" id="COG0252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_1_0_0"/>
    <dbReference type="OrthoDB" id="1659551at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asparaginase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="9">
        <location>
            <begin position="208"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="331" mass="35917" checksum="E9FD4E93E533A2C4" modified="2012-07-11" version="1" precursor="true">MKQRVVIVTTGGTIAMITDPATGASVPAQGLNKHVADVDGLKDVACTEHYEFSNIPSPYINPETMWALSKVVQKLLDREEVCGVVITHGTDTLEETAYFLDLTVRSEKPIICTAAMRNIDEMGTDGPRNVLSSVRVAVSPLAIGMGTMVCLNDEIHAAREVTKTYTSNVATFDSPGHGPLGIVDEDTVIFFRKPLLRAVFNVEKIESRIALVKTFTGDDGSILRILPDLGFKGVVLETFGRGNVPVEVYHVVKYLIEEKGVPVIITSRCFKGRVLGVYGYVGGGKSLADIGAIFAQELSPIKARIKLIVLMGITKEISEIERLFKLPLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3K6</accession>
    <name>I2F3K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730561.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0795"/>
    <dbReference type="EnsemblBacteria" id="AFK06509">
        <property type="protein sequence ID" value="AFK06509"/>
        <property type="gene ID" value="Theba_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0795"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_3_2_0"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="8338" checksum="93B4EE665D17E1F4" modified="2012-07-11" version="1">MPFYRYKCEDCGEEIEAFQKMSDEPLTICPACGGHLKKLVNNVGVVFKGGGYYSTDSKKSSASKSSSKPSTSTSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N3</accession>
    <name>I2F3N3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">Theba_0822</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730581.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0822"/>
    <dbReference type="EnsemblBacteria" id="AFK06536">
        <property type="protein sequence ID" value="AFK06536"/>
        <property type="gene ID" value="Theba_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0822"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_2_0"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="177"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="400" mass="45388" checksum="E6BF9A88EB356FF0" modified="2012-07-11" version="1" precursor="true">MKTEILGELQELARTAGYYVTESVVQNLDYPDPRHYLGKGKVDFAKRMIEAFGVSLAITRHELSPSQAMNLERLLGIHVIDRTQLILEIFAEHATTKEGKLEVELASLKYQLPRLKGFGRMLSQTGAGIGTRGPGEKKLEIDRRQAQDRISRLRKEIEELAKRREISRKKRQSSSVPLVSFVGYTNVGKSSLVSEISSEDLIIEDKLFATLDTRVRKAKLPAGMQLLVSDTVGFIRELPHELMESFKSTLDEVKYSDILVVVSDASDMAIKDKYSVVDRTLREIGAGEIRRIHVLNKIDLCTNERLAELEGSFPDSVMVSALRSYNIEGILNEITRKLFGEKSRRTLRLTPAEFSNFMRFRNSVEVLSESFDRELIEIVYLSSDEINERLISSICEEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N9</accession>
    <name>I2F3N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492531.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0828"/>
    <dbReference type="EnsemblBacteria" id="AFK06542">
        <property type="protein sequence ID" value="AFK06542"/>
        <property type="gene ID" value="Theba_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0828"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172543_0_0_0"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="86" mass="10007" checksum="1464FC4E45C0FA4A" modified="2012-07-11" version="1">MSRLHELSFFSLAEAKTHFSKVVDDCEKADIIITKNGLPKAVVMDYRKYVLFNRFLERVYDLYLMDAGDEAMDVEIKDLIVQVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S2</accession>
    <name>I2F3S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730613.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0865"/>
    <dbReference type="EnsemblBacteria" id="AFK06575">
        <property type="protein sequence ID" value="AFK06575"/>
        <property type="gene ID" value="Theba_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0865"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825860_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="343" mass="38148" checksum="FE009CDFF7104171" modified="2012-07-11" version="1">MKRVVVTADSHFPSKSDCGFALIDVSNPLEPVVLSRSKLPDHCGSFASSNGFLYCTLPGSFMIFDISDPFAPRLLSRLAANGGCQIVISERRKKAFLADWKNGVLIIDINDPYEPRMIGRMGCNGDERNNGEIHPYGVSGLAVHNGLLFASTMDYDMLQNREALYVFDISRPRSPKWIARVNTYPCRGHGIVLKRNYVVIVGLRSTMVIDISRPEEPATISLIETPDRFGMNPWLSGDYLYVPEIVYEPNKKLAGLRILDISNPLHVESISELLIPARAATNVKVVDNLAYLSCQCGLAIVDVADPEKPKLLNLCTPCEVDKIAEGIEVIDYRDEVFKEERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T3</accession>
    <name>I2F3T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730624.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0876"/>
    <dbReference type="EnsemblBacteria" id="AFK06586">
        <property type="protein sequence ID" value="AFK06586"/>
        <property type="gene ID" value="Theba_0876"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0876"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_3_3_0"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="105"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="230" mass="25594" checksum="7A65E4AEF8631459" modified="2012-07-11" version="1" precursor="true">MHSKRRIVLSTIVMLFATLGLSLTICIDPGHQKEADFTHEQIAPGSETTKARVSTGTRGSSTGIPEYVFNLEFSFMLRDRLLEEGYDVVMTRESHEVNVSNIERAEIANEAKADLCVRIHANYSSDSSLKGFMLLVPSSSSVHTAPIYEESRKAAEKIHASLLQISGIESLGIRVRDDMTGFNWSKVPVIIFEAGYMSNPEEDVLLSTQDYREKLVEALVTGIADYFLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V1</accession>
    <name>I2F3V1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">Theba_0894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492600.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0894"/>
    <dbReference type="EnsemblBacteria" id="AFK06604">
        <property type="protein sequence ID" value="AFK06604"/>
        <property type="gene ID" value="Theba_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0894"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_1_0"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="194" mass="22047" checksum="06C2F6A1D7695D5E" modified="2012-07-11" version="1">MIESMCSGNRIGIFGGSFDPVHNGHIIVAILAIEQLELERLYVTPAYIPPHKVSSTIAPYEKRMKWLEIAFEGVECAHVSDYERDRGGVSYSLFTVRHFSRVHNCKPFLVIGEDSLASLDSWYEYESLLREATIAVYPRNSIEVETALKAEIVWLDAPRFEISSTEIRRRLSEGKSVRGMVPDSILDEVEDFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F411</accession>
    <name>I2F411_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730685.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0958"/>
    <dbReference type="EnsemblBacteria" id="AFK06664">
        <property type="protein sequence ID" value="AFK06664"/>
        <property type="gene ID" value="Theba_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0958"/>
    <dbReference type="eggNOG" id="COG3634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082677_0_0_0"/>
    <dbReference type="OrthoDB" id="1300544at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="134"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="23581" checksum="E5F3B7A908656F7C" modified="2012-07-11" version="1">MAKLLPDNITKQVKEIFSNMEGSVKALLFKSEKNCDYCSTAEQMLQELSELEAKISYEVHELDSEMADKYSVELAPSIILLTPDGDDKGVRFLGIPAGHEFGSLLQNIVSFSKGAIPELSEESIKKIETISSPVDIKVFVTTTCPYCPKAVLTAHNIAMVNENVTAYMVEANEFQELSKKYGVSSVPQIVINDKVTFVGAYPEGQFVDQVMKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F418</accession>
    <name>I2F418_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730692.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0965"/>
    <dbReference type="EnsemblBacteria" id="AFK06671">
        <property type="protein sequence ID" value="AFK06671"/>
        <property type="gene ID" value="Theba_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0965"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033147_4_0_0"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="523" mass="57170" checksum="4E1678C96DA9AF37" modified="2012-07-11" version="1" precursor="true">MKSRHRVPRIATQLLFLLLVLYISVGHYLSEKGIAELAGTTSLHAVCPFGGVVTLYNLVSDGTYVQKIHPSNLFVLGGLLISLVIAGAFFCGWICPLGSVQEWIGKAGRKLLRSHYNKVPAGLNKILSLGKYAMLIFVIVQTARIGTLSFSSFDPYYNLFNIWTDEIALSGYIAVFLTLGASLFIERPFCRYACPLGAINGLFNRFSIFRIRRQSSTCIDCGLCDKVCPAGINVSKVSSVNSPACNRCMKCVDICPANSNSTLTIEVGLSKKSSKASKTVSVKTYIILALSAFLVPVGLSVLTGKFETEKTRVYIVPDDIKGSTSFEEIVENYPISKEQLFNGLGIPEMVSVELKVKDLTGILGFIGEEEVISREHLSALIGKLGEPISSLAEHSKVDFENIIEFVQSSGLDESTVVSEVMASGPPGLFTYLFSGRWPFETSGDGAVIEEKETGSENHGQSASVDIKGSTSLLEIERMVPDFEAFLEYFGLPIDEPKSSLLKDLKTKYQIEISDIKDYVSNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F428</accession>
    <name>I2F428_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492705.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0975"/>
    <dbReference type="EnsemblBacteria" id="AFK06681">
        <property type="protein sequence ID" value="AFK06681"/>
        <property type="gene ID" value="Theba_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0975"/>
    <dbReference type="eggNOG" id="ENOG50330XX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233832_0_0_0"/>
    <dbReference type="OrthoDB" id="1233799at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045706">
        <property type="entry name" value="DUF6062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19538">
        <property type="entry name" value="DUF6062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="224" mass="25481" checksum="8D85EB634EB54629" modified="2012-07-11" version="1">MLLKADNVLESEIISLLEEGELCPVCRSMEKSVDGWIVGAFSNLLHNEGARMELRRNGLCTVHLKRIVEVAKERSEVGSLAVSIMFKEILAAQVSWLDEKDVGFLSRKKPKSGSCVLCSVASNSERIYLSAFVKFLQRDEVQRSYENSRSVFCVNHSRYIIKNMRNSCGQWLAGTQRNKYEDLTAEMENYISKHDYRNTTPVGQERHAWLNASKLIGERDAKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>I2F493</accession>
    <name>I2F493_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">Cytidylate kinase</fullName>
                <shortName evidence="13">CK</shortName>
                <ecNumber evidence="13">2.7.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">Cytidine monophosphate kinase</fullName>
                <shortName evidence="13">CMP kinase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
                <shortName evidence="12">HMBPP reductase</shortName>
                <ecNumber evidence="12">1.17.7.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">ispH</name>
        <name evidence="13" type="synonym">cmk</name>
        <name evidence="15" type="ORF">Theba_1041</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the IspH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="13"/>
    <dbReference type="EC" id="1.17.7.4" evidence="12"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730752.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1041"/>
    <dbReference type="EnsemblBacteria" id="AFK06746">
        <property type="protein sequence ID" value="AFK06746"/>
        <property type="gene ID" value="Theba_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1041"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537252_0_0_0"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="14">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="436"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK06746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="507" mass="55911" checksum="BCB778E2C3AD865F" modified="2012-07-11" version="1">MRIAIDGPAASGKSTVARLVAEKLDFVYIDTGAMYRALALKAKKAGISFSNADEMAELMSHTYFSLSDSGIILDGSPLGDEIRTREVSLLSSDIAKYSYVRDFLTEQQRTLSKQGNVVMEGRDIGTVVIPEAELKIFLTASAGERARRRVKQLKSSGVEATYDEILAEIERRDLNDSTRSVAPLKAASDAIILDTTGMSIEEVVSRIVSLAEKRQRVHLARSVGFCYGVDRAVSEAVKLLKSGKKVYATGEIVHNEKVMDDLKQLGLEVIDDCILSGRHEGVAIIRAHGIDPASEEKLRRVFDEVIDLTCPIVYNVFSLAVDLQRQGSFIVVYGKKNHAEVTALSGRLNRYLIVEPGENYEEVLKKLEGLDQIAIVSQTTMSSLEFENFSGFAKSRLGERVAVYNTICKVTIQRESEAERLAKISDTVIVIGGKNSSNTKKLVEIVQRLGKRALHVTELTDLPQGDMGKVAIISGTSTPYEQIQKILDYIDNKREVTNNGRENESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K5</accession>
    <name>I2F4K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730847.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06858">
        <property type="protein sequence ID" value="AFK06858"/>
        <property type="gene ID" value="Theba_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1160"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067316_1_0_0"/>
    <dbReference type="OrthoDB" id="1488991at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045738">
        <property type="entry name" value="DUF6088"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19570">
        <property type="entry name" value="DUF6088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="211" mass="24873" checksum="F0B12FE88C69C11E" modified="2012-07-11" version="1">MKEISTREKISNYIKRNPKSRIYSISDFSRFGTYDSVRKALSRLEIEGRLIRVSRGFYKSQEFNILVNEEVASDPDQFARAYAESYGWKIAPHKETALNMLGLSTQVQNVFQYVSDGPYRTVSLNDGRKIEFRHRTIREISKLSYKEAALLEALKTLGKERISPDVRSRILRRFSKKELEALRKRVQKSRKWIYEEICRLIERSENSVSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P4</accession>
    <name>I2F4P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative toxin-antitoxin system toxin component, PIN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1200"/>
    <dbReference type="EnsemblBacteria" id="AFK06897">
        <property type="protein sequence ID" value="AFK06897"/>
        <property type="gene ID" value="Theba_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1200"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1893733_0_0_0"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="134" mass="14920" checksum="EFB8B7860084E16A" modified="2012-07-11" version="1" precursor="true">MKVVIDTNVMISAALGSKTCSKTVLKALEQGVIEPQIFVLELQRFIMKLKGKEKYGHIQLEGLSNFIDYFLMTVEIVDDYKLVTYSTDFPDNHFISLAAARNALLITGHKLCLKSALGGNVNCRTPAQYLSDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S1</accession>
    <name>I2F4S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="7" type="ORF">Theba_1236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1236"/>
    <dbReference type="EnsemblBacteria" id="AFK06924">
        <property type="protein sequence ID" value="AFK06924"/>
        <property type="gene ID" value="Theba_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1236"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="174" mass="19963" checksum="085C921624D5115F" modified="2012-07-11" version="1">MKIQKTPLCRWAVTHSKVQTKRKGEIEKTLGYLVDHNGNKIEKKWYVVDATDVPLGRLAGQIAMVLMGKNKPYYTPHLDTGDFVIVVNADKVKLTGKKLDQKKYYRYSGYPGGIKERTARQMMEKFPDRVVRLAVKRMLPKKALGEKMLKKLKVYAGPEHEHAAQKPELIELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4W4</accession>
    <name>I2F4W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1279"/>
    <dbReference type="EnsemblBacteria" id="AFK06967">
        <property type="protein sequence ID" value="AFK06967"/>
        <property type="gene ID" value="Theba_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1279"/>
    <dbReference type="HOGENOM" id="CLU_2735347_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="71" mass="8260" checksum="4302D23A8D587A33" modified="2012-07-11" version="1" precursor="true">MRLEVRRSSSYRSFNLFPLTSAFTKNLDAQRRNEEPVFIGGDAVPLTGKWFSSAYSGFMLLSEQRLSRPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X1</accession>
    <name>I2F4X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730950.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1286"/>
    <dbReference type="EnsemblBacteria" id="AFK06974">
        <property type="protein sequence ID" value="AFK06974"/>
        <property type="gene ID" value="Theba_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1286"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="276"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="534" mass="58913" checksum="8843E13DCF8B915C" modified="2012-07-11" version="1" precursor="true">MDEKQYLLKMENISKEFFGNQVLKDVTLRIGKGEIVGLVGENGAGKSTLMNILFGLPVIHETGGFQGRILLDGVEVNFASPFEAIEAGIGMVHQEFILIPGFTATENILLNRESTNYNIFVEVFGERLRTLNREEMHKRAVAAIEKLEVQLDPDMLVSEMPVGHRQFTEIAREMDRKSTKLLVLDEPTAVLTESEAETMLTAARRLANKGLSIIFISHRLSEVLKIADRLVVLRDGQVVRELESSKTTPREVASLMVGREIKDSSSVRANIGEEPEIVLDIKDLWVDMPGEQVNGVNLQVHKGEILGIGGLAGQGKLGIANGVMGLFPAEGEVYYKGERLPLNNPVGVLSRGIAFVSEDRRGVGLLLDEPIDLNIVFTAIQIQGRFIKNLLGGLIKWRDDKEISRVAREYVESLQIKCVSEKQQAKELSGGNQQKVCLAKAFVLEPDLLFVSEPTRGIDVGAKSVVLETLRTQNREHGTTIIMTSSELEELRSICDRIAIVSEGRIIGILPPTADPADFGLLMLGEQEEVKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F525</accession>
    <name>I2F525_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="12" type="ORF">Theba_1340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486754.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1340"/>
    <dbReference type="EnsemblBacteria" id="AFK07028">
        <property type="protein sequence ID" value="AFK07028"/>
        <property type="gene ID" value="Theba_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1340"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_0_0"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="46792" checksum="30283359C059BF37" modified="2012-07-11" version="1" precursor="true">MAKKVVALILAGGQGTRLGLLTDEVAKPAVPFGGKYRIIDFSLSNCVNSGITAVGVLTQYRPHILSRHIGIGRPWDLDRKDGGVVILPPFIAQGDSNWYKGTANAVFQNIDFVDDFDPELLVILSGDHIYSMDYNEMIDYHLSKGATGTVACMRVPLSEAHRFGMMITDFENKITDFQEKPKEPKSDLASLGIYVFDWKFLRERLIQDEKDPESDNDFGKNILPKIVQDNAGKLFAFVFEGYWRDVGTIESLWEANIELTRPIPPFNLHDPSWRFYTQTEEYLPAYVGTSSYVRNSLINEGAEIYGRVENSVIFQGVQIGEGSLVKNSVVMTNSKIGRNVVIERGIVGEGTFVKDGVVLGYGDEVPHETQPHIYNAGIVVVGSDVVIPQNTKIGKNSAILNHVREEDFEGDVEGGKTISPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F547</accession>
    <name>I2F547_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730996.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1362"/>
    <dbReference type="EnsemblBacteria" id="AFK07050">
        <property type="protein sequence ID" value="AFK07050"/>
        <property type="gene ID" value="Theba_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1362"/>
    <dbReference type="eggNOG" id="COG4902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051317_1_2_0"/>
    <dbReference type="OrthoDB" id="1938827at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01048">
        <property type="entry name" value="Ferritin_like_AB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019243">
        <property type="entry name" value="DUF2202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09968">
        <property type="entry name" value="DUF2202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657764" description="DUF2202 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2202" evidence="2">
        <location>
            <begin position="26"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="187" mass="20941" checksum="9E3C150D262B0ABA" modified="2012-07-11" version="1" precursor="true">MKRLFSAILMVLIIGTMTLASGLTAEEDGIVFMREEEKLARDVYTVLYEIWNVNVFKNIAESEQQHTDAVLSLIGEIGLEDPVGENDIGVFTDPELQKLYDELIEKGSKSLLDAVEVGLLIEEIDIADIEELLAGEIGSRTRTVYENLLRGSESHLRAFLRQYEKLAGSYSPEVLSVDRFNEIVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F569</accession>
    <name>I2F569_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731018.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1384"/>
    <dbReference type="EnsemblBacteria" id="AFK07072">
        <property type="protein sequence ID" value="AFK07072"/>
        <property type="gene ID" value="Theba_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1384"/>
    <dbReference type="HOGENOM" id="CLU_1658738_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="159" mass="18356" checksum="264BA5A1B1602A5F" modified="2012-07-11" version="1" precursor="true">MSDEKRIQLKNRGIQLHSSFQNERREAAEEKADLRDALELYDFSLKSRVVSGYSVESLVSLSSIKKMCDNLEKKLDRQQKSFRPHSVVMKGESVTPVEIILKETPLKQWYTTGKTLGSLASIGAKVALQLLKNQKDEKSFRKLRLLEIEIMHRKLNEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F573</accession>
    <name>I2F573_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731022.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1388"/>
    <dbReference type="EnsemblBacteria" id="AFK07076">
        <property type="protein sequence ID" value="AFK07076"/>
        <property type="gene ID" value="Theba_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1388"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_0"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="100"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="341" mass="37498" checksum="D50F0FB8E90F2E31" modified="2012-07-11" version="1" precursor="true">MKLKREILIIATSCVLLCPTNFSAYSLSEIGELAELLKQLFLASRTARDFSLESLKVDTEEFPAVDFVVKEDVVYSEVDGEILTMDVYYPARTTAPRPAILYVHGGAWITGDKRSGPGVVVTGELIRAGFIVFSIDYRLAPKWKFPSQVIDVKTAIRFVRENSTELLIDPEAIGGFGTSAGAHLVTLAALTANTGMFSEDKYSGQDENLFCVADLYGPTDLEALFEGIEREVAELIFGNEEGILRKASPINYVNKDSPPFLIVQGDSDLVVPVDQSKRFFEELTAAGCYSKLVVVENAGHGLVPDGGEIKPSLIDVAKIVVGFFQRQMIIQQSRINLLLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F588</accession>
    <name>I2F588_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731036.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1403"/>
    <dbReference type="EnsemblBacteria" id="AFK07091">
        <property type="protein sequence ID" value="AFK07091"/>
        <property type="gene ID" value="Theba_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1403"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_4_1_0"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657617" evidence="1">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="44716" checksum="E33DEC1C58326AAD" modified="2012-07-11" version="1" precursor="true">MKRVLLVLLVVAVTAFVAFAATPIKIGAVVPLGDITGDQSAKAMKLAIDEINAAGGLLGRPLELIVVDSELKPEKGAAAIEKLATVDKVDFFVGGMASSVHLAQIPVMKRYQKITIWSGAASYLCENAVGPDADWYFHLHPWDYQQGASYGLGWTELAEAYPDIEIEKIFLAYEEGGFGSASHESYLVLQSQANQGEGAWAAVMGDYMGVSFKSAALGGGDYRAMLQQAKAYDPDLFVWAGYDADALPMLQQAKEIGFAPKFFVGAPPGWPAHFGDSPLAEAVTLYGMWAPTINKVSPTAEHFWNAYIEKYNEEPATYFAPLGYTNIYFLAEGIKAAGTLDKAELIKALEEVEYASPIGEVLKMSPSNVIKHQGFTGQKILQWQGGEQQVIWPLNLKTAEPIYPFPSWEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F599</accession>
    <name>I2F599_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731047.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07102">
        <property type="protein sequence ID" value="AFK07102"/>
        <property type="gene ID" value="Theba_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1416"/>
    <dbReference type="HOGENOM" id="CLU_2035313_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="121" mass="13931" checksum="A3417052BA4ECE9C" modified="2012-07-11" version="1">MNLDKRHIGIVLHGSFCQQRLAVDLVLEDAKVIALREKEKEIVKRQIKELVSEYAEKVLCSKAEAILDSNLLKDEEIEDLIQDGRAYTLAIALISDWLLSLPYPLEGKSYKKLRKLLEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B4</accession>
    <name>I2F5B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486940.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1431"/>
    <dbReference type="EnsemblBacteria" id="AFK07117">
        <property type="protein sequence ID" value="AFK07117"/>
        <property type="gene ID" value="Theba_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1431"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="30902" checksum="9552D6C14B3A9A9F" modified="2012-07-11" version="1" precursor="true">MKTVMKVLGKVFKVIALGLYLIAALLPLYWVVVTSLKGPREIYTFPLKYLPSKLSFESYSKLFGFANFGVYFRNSAIVALAAALAAMLISMFSGYALSRIRAKRFRNGTLLAMYFTQMVPPFILMAPLFVMLANYGMTDRLSTLFILYVTMVIAFSTIMSKSFFDRIPVSLEEAAVIDGCNTLQALFKVVFPLTRPGLAAIFSFAFVNIWNELFLASMFIFSDEKMTVPVALNSFISKAGISWDVLSAGLVVSLLPTMIVFAFAQRYIIAGLTEGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D8</accession>
    <name>I2F5D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">Theba_1455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1455"/>
    <dbReference type="EnsemblBacteria" id="AFK07141">
        <property type="protein sequence ID" value="AFK07141"/>
        <property type="gene ID" value="Theba_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1455"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="424" mass="48706" checksum="8385635D1F88C4E1" modified="2012-07-11" version="1">MHNIMITRIKGTQDITFDNIGYWHYVEEAIRSISHRYSFTEIRTPIFEATELFKRSVGESTDVVQKEMYTFEDKGGRSITLRPEGTASVARAFIENSLVNLGAPIKLFYNGPMFRYEKPQAGRLRQFHQFGAEILGSESPLADFEIIEMANSFLKELKVSKTKLFINSIGCPKCREDYKTALRDYYRDKLPGMCTDCRRRFDTNVLRLLDCKIDKELAKKAPSILDYLDEDCRNHFEELQWYLEKADIEYEVDPLLVRGLDYYSRTAFEIRSSSLGSQDQIVGGGRYDGLVEYIGGNSCPAVGFAIGLERIVMLLKSEKVNVNVPKIPQVAILAFGREENIRGFDYSRRLRKMGISTYVDVMERNMRNKMKHAARIGAKISLIVGKEEIERDIVTVKIMSDGSQFQVDSDYMSDYVVDKLRDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E1</accession>
    <name>I2F5E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Parvulin-like peptidyl-prolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731080.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1458"/>
    <dbReference type="EnsemblBacteria" id="AFK07144">
        <property type="protein sequence ID" value="AFK07144"/>
        <property type="gene ID" value="Theba_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1458"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030639_0_0_0"/>
    <dbReference type="OrthoDB" id="744756at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="222"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="733" mass="82862" checksum="9A3D014F996E7447" modified="2012-07-11" version="1" precursor="true">MPNRKSRGNSNFMKSVQRPIVWAVAILFGVGIVWWSVAQYLGGSSQGNEQGTGTEISFTETVGGLTKDGTPLSNSDYWITYSEYETSVRDTLTNLRSQGYNLDPYFETENYPSEMGIRYDLFKSLIDQKTLLFYATENGVLPTAEQVDAETNRIVDEYVADEETKSAIIYQYGSVDAFSELVRDYVVTQMLATNVTQKAIPDMEERFENYVNENMEDLKINYEKVDANHILVSDEASAVEIKSMIDSGEISFTDAATQFSIDTDTAINGGALGEFGRGQMVQEFEDASFDATPGLVIGPVESQFGYHLIRVNSKTTFDTFEEFASTSAYQTELGRFENEEFNKWIADYRQQNNLSYTINDPDLQMYARYDEAISDPEKSSALLEELEKDYFDESGNLLIGDSYLPVVFYTELAENEITKLRNQIFDLEDLQDLLLTLPSTATSLTIDEIDSRLETIPSTDTEARSVLTDAKRAKEYMSEFNVETPEEIEEALTEKRSLLDSKNLRFENSVRYLYSVMPNSARVINYMYQIDGDNPEVVYMYNETSYNTNIRPLLESPELLDSYLEYYGQYFGAQARSLLLDSPIQGIESDLNQKVINSTEAATDLKMSALYLLVDIYEKMANMEQNEQLTQIYLLSEKHYLEKLAELYPEDETIRSLIETIKFQISELNAQNNVDAIPTADATSTETSTETLIDTEIGTGELEVPLGNDEHSSIGDVDLDVNFDSEGATETVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J8</accession>
    <name>I2F5J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein (DUF2207)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFK07201.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07201">
        <property type="protein sequence ID" value="AFK07201"/>
        <property type="gene ID" value="Theba_1525"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="415"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="435"/>
            <end position="454"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK07201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="533" mass="61237" checksum="23B9901F95DFCBF5" modified="2012-07-11" version="1" precursor="true">MKRKFERKYFFIIFMMVSGFFIFIALGNGFWRESAPYKIDSVEINAKLDEQGDLHVEELSVYILSRNNRTASKKLHLSYPSVLKSYSVEIPNDAGFVKEISSSPGGFDARIFLEQEVSEFVMNTEYVISGVVEVGSDIAVLSYRFWEPNSDAMTRDISLAMELPETIISRLTEDDISVRPFKEASFEIEGNLVKLQMKSVLSNASGEIKISFPKSIANTMPNAVNTTISKSALRKEHESAMFQQAFLSGLIGFQIAVPFFVIFFTFILFGIEPQVKSEIGYRLYDVPGYLLNAVIKNPFQEIDHNGFLSTIMEMHNSGEIQIGENTISFETSEKGIPTQQKWALQTLKSLRRNEDGSIEIPDAESDAFSFDEFKEQYGFWRKHAMRVVKSGRFYEYLGSTVMSVFSILYLIIWSLILKFVFGNWQVYLSFPDESLAISIVLYADWCLGWLLLVLPKNIFARWTPSGRLFYMEWKKTEKELLSKQSWTNDDIAKLVALGHLQDIISNRKRVSDQQLTLLRQLQRLEMIFNKVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L2</accession>
    <name>I2F5L2_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1539</name>
    </gene>
    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1539"/>
    <dbReference type="EnsemblBacteria" id="AFK07215">
        <property type="protein sequence ID" value="AFK07215"/>
        <property type="gene ID" value="Theba_1539"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1539"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_1_0"/>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="219" mass="24527" checksum="2C5324362F214B96" modified="2012-07-11" version="1">MDFDRLINCIPHIKEILGVVEKAFENYDDPAHDISHVLRVTESASEIAIREGANLEIAVIAALLHDIKRPEEDFTGIDHAESGAKYAFQLLNEMGFESQFTFEVSEAIKVHRYSSGLNPSSMSARILQDADRLDAIGAIAVARVFSFSGKTGTPLHSPKLKPGDSYKGYSSTAINHFFEKILKITPESFWTKTAKEIAENRYRFVVQFVKQFLSEWGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q2</accession>
    <name>I2F5Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP-type C4-dicarboxylate transport system, large permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731161.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1585"/>
    <dbReference type="EnsemblBacteria" id="AFK07255">
        <property type="protein sequence ID" value="AFK07255"/>
        <property type="gene ID" value="Theba_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1585"/>
    <dbReference type="eggNOG" id="COG4666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645132_0_0_0"/>
    <dbReference type="OrthoDB" id="929438at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="17"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="454" mass="48444" checksum="2BDF688363551876" modified="2012-07-11" version="1" precursor="true">MTAIYTPEVWYFLVMLATFVGLAIIKIPISVSLMFSALAGSIAFGEFFPLRHLVEGGFGYIDTILVIGSAMIFMESIKVSGLLDTIAGNMTIAFHKKPTFLLVLMTFFIMIAGMITGSSTATVLTTGAIAFPVLKTLGLSKRRAGSIIAMSGIYGMIAPPINLPAMIIGQGVDMPYIGFTNPLLLMTFPLAIVTSLIIGVRQVKPVDLQEFVRTREREPIKGFAVYLPLIIMVILMVLENVSWGFSLGLPLIFMISAIVASLTGARGNLFKISLSAVQNSLGILSILIGVGMFIQIMTLNGVRGLIVGFLNGLPQGALLVGIALGIPAFGAVSSYGSASVLGVPFLLAFLGNNDIVVCSALSLLAGLGDMVPPTALAGIFAAHVVGEKNYFKIWLSSMPAFFITMIFATLTIIFSNEIGRFANSWLFYPLFIAGLVVVSVALLLVDKRKEMSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R2</accession>
    <name>I2F5R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489366.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1600"/>
    <dbReference type="EnsemblBacteria" id="AFK07265">
        <property type="protein sequence ID" value="AFK07265"/>
        <property type="gene ID" value="Theba_1600"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1600"/>
    <dbReference type="eggNOG" id="COG5361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027269_1_1_0"/>
    <dbReference type="OrthoDB" id="547506at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657772" evidence="1">
        <location>
            <begin position="24"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1254" evidence="3">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="337"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="467" mass="52210" checksum="89AB5792D51BA5EC" modified="2012-07-11" version="1" precursor="true">MLCRKHIALLIITLSFLSLLLSSENEFTTDCDEAREIAKQAYIFAYPMLEDFKTMTIQAIGPGLFNKFYNSRKLRGPDYKEVVRPNNDNIYSALWLDLRSEPVVVSVPAVEDRYYSFQMIDMYTHNFAYVGTRATGTGARTFVISGAFWQGSVPTGVDDVFRSEGNFVLCLVRIAVDMEVEGDLDKVLEIQKGHEIQPLSSYLGEEAPPAADPTIFPTYDTTKAESVEFISYFNFLLGQLEVHPSEKELIEQFGKIGIGPNLPFDFNSMPLGIREAVEEGIKGALETIRNPGEMVGISKNGWNLTKRIFGSREEMQGKYEVRAAAAYLGLYGNSLEEAYCPNGLVDGDGDVYDGSKFKYVLSFDSDELPPVEPKGFWSITMYGEDQFLVANEINRYSIGDRTNMKYGEDGSLVIYIQHESPGADKESNWLPAPDGIFSISMRIYLPSEVALNPLYCPPPVMKSGMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S3</accession>
    <name>I2F5S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas10/Cmr2, subtype III-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731175.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1612"/>
    <dbReference type="EnsemblBacteria" id="AFK07276">
        <property type="protein sequence ID" value="AFK07276"/>
        <property type="gene ID" value="Theba_1612"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1612"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012640_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038242">
        <property type="entry name" value="Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024615">
        <property type="entry name" value="CRISPR-assoc_Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013407">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12469">
        <property type="entry name" value="DUF3692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02577">
        <property type="entry name" value="cas_TM1794_Cmr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="466"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="790" mass="88533" checksum="1B7D7C73956BFC88" modified="2012-07-11" version="1">MNWEKKIIALMHDPLFKAMDIRGHESSSAEILKALGISPDKVKEEDWIASAMDRLAIPWEKSNQVRVSLDDTGGFVHSLSSSKLDVLKHLPNLDSARSQFMANLRVISEGNKKENLFHALWWQLPDMMEGSAFLPADTRIPNHSIVDHLDSTSSLAGTIENGKIKASLISVSVGPVQSFIAAARKTMDLWSGSYLLSLITYKGIEYVGQKYGFDCVIFPSLRNIAFVKKSLSEWGVKFTVDSKVPKPSTRVASLPNRFVAIVPTSEVKETLKNVEKAIKDGWKEIYSVSLKAGKPLDETNLQMQLDTFPEVFTTSQELIEIENAKEIISNLYNDSGIKDEIDNLNSLSTQHGAHKPNAGALYSYSYRLLRSRADARKTLRTFSHFTDNSSVNGKTLQGDQFNGDMKAIFKLKDGEKTDHLNAVNAVKRLYASEINEKFPSVDEFAGKNEQKFIEFTGNMPESYKNSYYAILLMDGDRMGKWIGGEYAPQITEVIAEPLRTAIVSSDLPTKMKDYILMRKTVQPAYHRTVSRTLNIFSSLVQLAVEKHGGELVYSGGDDVLAFLPAVSVLECADEIRRMYSGTGDVELDSPAGKLQFKDEMLWIKGKPHSPMMGWKATMSAGIAVVNKKFPLSQALRIARESEHIAKDGLGRDSFVVSIVRRSGQISRNGAKWSTKDGSFNTIKSLREMIKKMDSSGFGSRSLRKLFGDDLILSNDEYVNKYIPYVLKKAGSRKEDDGSFERMFKNYFRKMIDLEKGIEAITEENSDLFEARKRAVDLLLVQDFLLRGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Y4</accession>
    <name>I2F5Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1677</name>
        <name evidence="3" type="ORF">Theba_1744</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731232.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1677"/>
    <dbReference type="EnsemblBacteria" id="AFK07337">
        <property type="protein sequence ID" value="AFK07337"/>
        <property type="gene ID" value="Theba_1677"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07400">
        <property type="protein sequence ID" value="AFK07400"/>
        <property type="gene ID" value="Theba_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1677"/>
    <dbReference type="KEGG" id="mpg:Theba_1744"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362352_0_0_0"/>
    <dbReference type="OrthoDB" id="129736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="116"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="693" mass="79483" checksum="C58154E14B114B24" modified="2012-07-11" version="1">MLLTDHVDIPTELIRAQEEERLVVFAGAGVSMASPSNIPGFVDLAKAVAKSYGQKYYVKQQRVQPPDVFLGSLNSKNGGQGVHEIVKQIMSRETSRPSQLHNLIPLLFKSARDLKIVTTNYDAHFLTVLKNYGERYDGFDIFRAPALPRGDDFRGIVYLHGNVEQDSRWLVVTNRDFGRAYLTEGWARDFLRDLYLSDYTILFIGYSHRDTIVDYLARGLDIRQSNRYALVSASDAERWKEINVIPVSYPLTPEKKKVHYELQKALENWTSLASSDLEIHTDRIKSIAGKKPGIDQKVDSYLTYCLNREDLTEVFCRFAEGFAWVEWLDSKAMLDNLFREEEPLTEIEKSLTRWFVKTAFVSSSQEHLTFLASRRSSLNPYLVSSIVEQMADSDLEIPDTCQAEWLNLILNNWHKGETPCLAMLKALKKVDVTTNPWIITKAIQSFFSLSQTGKPAKLSLFHRQYDLEPLVKTDCLKKFWSEIIEPNLDILHEDILSILTSQLMKAVTDMSVINGSVREYDSICSARKTIEESEPESSPEWLHIYIDFVRDTILHLIKTDNKDRNFYYEWWRRSRAPILWRILLYAVSEDPSCSDDDRVRIVLDNGWLINPVLKAETAKIISNSLRTTSTSVLMKVVETIERELDRLSRVPNLGDGQRSNPAIGEILLAIEKSGVDSPEIKKLVKPLKEKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F626</accession>
    <name>I2F626_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07379">
        <property type="protein sequence ID" value="AFK07379"/>
        <property type="gene ID" value="Theba_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1722"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540588_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="504" mass="57269" checksum="1E71DCD44E1A7F39" modified="2012-07-11" version="1">MGGFWLDKYRLFSSYFLSLNGKRVSPTSFQNKVSERIVNYPGADLRILAHPERPLIAIRIESRAKIEFCLRQEMDLVWLEDRPSGNISLRVENQDRDTIVWRELEGMSSFVKVNGKATSEGDWLKLSRRGRLEAVIALGRPGKEGYEQYLLEREEHNRRYLPPFQDTIPFWARAGALELFFERDVGCGFVAGLGEFPWWFGIDGVYTCLGLLDTPMLELVGKTVDNLAKFGNGLAPHEVTTAGRIYAYGRMNEIIAFAYLALKYAVKTSKKEYLELVDNALSHVSGHLSRKLYPQGEGIVEVPISGEFALLDSACWLYSMLKELRDSNMMKDLKNSQFAAWLLERYDREFLKDWYGKDGLFYDALTEKSGNFEGHFIQIYPLSMGLIRREIGERLLAKMEKIGYFKEPGLIHSLPLKTFEAGDYGEGDKNDIVWSLPTLLAIEAGIRYGRPDLSEKFILSLENSLKSEMYGALPEILPAGGCTIQAWNAYAIPLIEHMNSPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F646</accession>
    <name>I2F646_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1676</name>
        <name evidence="3" type="ORF">Theba_1743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731231.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07336">
        <property type="protein sequence ID" value="AFK07336"/>
        <property type="gene ID" value="Theba_1676"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07399">
        <property type="protein sequence ID" value="AFK07399"/>
        <property type="gene ID" value="Theba_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1676"/>
    <dbReference type="KEGG" id="mpg:Theba_1743"/>
    <dbReference type="HOGENOM" id="CLU_2936261_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="60" mass="6385" checksum="8E5570699061C262" modified="2012-07-11" version="1" precursor="true">MSRTVLMLAGVVVLVMALLASFNVGGIVIPAWYVSLKWIGGAIMILVAYMDKGKKAKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F688</accession>
    <name>I2F688_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731272.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1790"/>
    <dbReference type="EnsemblBacteria" id="AFK07441">
        <property type="protein sequence ID" value="AFK07441"/>
        <property type="gene ID" value="Theba_1790"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1790"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_0"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="32734" checksum="98AC5BDCDE68AF25" modified="2012-07-11" version="1">MPAVDIAIDVGGTKTLVSAFDEKEVEPYSSEEFPTRPAEGIDSFFERLSNICLRMKGSRNINRWGLCTAGAVSPEKGKLIWSPNLGWKDVELFKRASSFLGTEGVIENDCNAAAFGEWEFRKDIESLIYVTVSTGIGMGMVVRGKILRGASNAAGEIGHTIVKADGPLCTCGRRGCLQAISGGRGLEIRAHDSLGIEIGTKEITDRAELNEPVFKEMITEASETLGRFLCNLIDSLDPSVLVIGGSLGKNRYYFDRILKTIEENYYRVPGKKVKIELSSIEPNPNILGILSLSRKTHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F690</accession>
    <name>I2F690_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07443">
        <property type="protein sequence ID" value="AFK07443"/>
        <property type="gene ID" value="Theba_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1792"/>
    <dbReference type="HOGENOM" id="CLU_2437395_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="90" mass="10342" checksum="132F7D00EC90EA9D" modified="2012-07-11" version="1">MTWLFSPETLGSFAIIFKLYREWEGEEKAVDIRVFNVEMDDRTLSECIPDYVTVLDSSPGFISRVIYSQPLLRKTYRLDFHGACGAIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B6</accession>
    <name>I2F6B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">Theba_1818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488416.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1818"/>
    <dbReference type="EnsemblBacteria" id="AFK07469">
        <property type="protein sequence ID" value="AFK07469"/>
        <property type="gene ID" value="Theba_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1818"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_0"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="248" mass="28474" checksum="6F73D13283673BBC" modified="2012-07-11" version="1">MTKLVLVRHGESTWNKENRFTGWTDVDLSEKGREEAENAGKVLKADGYDFDLAYTSVLKRAIRTLWYIMDEMDLMWIPVIKDWRLNERHYGALQGLNKAETAAKHGEEQVKIWRRSYDIRPPALEESDERFPGHDPKYRSLSDEELPRTECLKDTVARFLPLWKNEISTQIKSGKKVLIVAHGNSLRALVKYLDNIPDEEIVGLNIPTGIPLVYELDDGLKPIKHYYLGDPEEIAKAQQAVANQGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D8</accession>
    <name>I2F6D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFK07491"/>
        <property type="gene ID" value="Theba_1840"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="113"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="135"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="33422" checksum="72547F9B0C82FD34" modified="2012-07-11" version="1">MEGFKVCKSSETIETVAQKNSSLSLLAHGDGVEISMYELRSGVVTFLDTFSGGDLLEFFYIIEGTISCNYSEKEVNLGPGDYFYAHNLKSPVELKPQTDVRLLHVSSRPLFKYVSNNMGVMKDILSKVEIKDSYTHGHGKRVRDVSLAIARKLGVPSEKQEVIAMGALFHDIGKIEIDDSILKKPSRLSREEFEIIKLHPVTGCEMVKGNFLEETQDIIRHHHERLDGSGYPDGLKGSELSLEARIVAVADSFDAMTSRRPYREAMSCNEALQELKSKAGLLYDSKAVKALEECIDEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6F5</accession>
    <name>I2F6F5_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR33677"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10514" checksum="948710A2E25D7C07" modified="2012-07-11" version="1">MDNHSHHKHSGALKILRTARGQIDGIIKMIEEERYCIDISTQLLAVISLLKKANTTVVNKHIETCIREAIDSGNVDEKIGELETLMKYIEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J9</accession>
    <name>I2F6J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosylase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFK07552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="gene ID" value="Theba_1904"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="33860" checksum="2A92B4D5DC6F9DAB" modified="2012-07-11" version="1">MIKLERHPLNPLFSPISQHHWESKYVFNCAVIKRQGLFHMIYRAQGEDMVSRMGYAVSLDGVRFNRLEKPVFTPGSQWELYGVEDPRLTEIEGKVYMQYTAYSPKGVRISMASTTDFLRWERHGVIIPDVNNKDAALFPAKVKGRYLMFHRIEPDMYLAYSEDLRTWTEFTPIAGPRSGKWDNLKIGVGAPPIETEYGWLVLYHGVENTASPTYRLGFMLLDLENPEKVVKRSDEPILEPEEEWEIFGGVPNVVFSDAMVEHEEKYFVYYGAADNHIALATIDKETVVNWIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K3</accession>
    <name>I2F6K3_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1908"/>
    <dbReference type="EnsemblBacteria" id="AFK07556">
        <property type="protein sequence ID" value="AFK07556"/>
        <property type="gene ID" value="Theba_1908"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1908"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="35864" checksum="567F7D9AB3C21164" modified="2012-07-11" version="1">MSAKLSDVAKLAEVSTATVSRVLNKSGYVSKKSREKVMLAVEELEYKPSKVASFLASRKLAFNIGIVAGKRLFRVLSDQSDQFYTIVLKGIEEFFAGNNMRGSLVPSNNFSEDYDGYLLIGGEITEEDIKKAKETKKPVVLIDQYLAGVKVDCVVSDGYDGAIYGMKKLISKGLKKIVNIHGPLSHFGFKDRFDGYISAMEGAGYLPKAYEYDEDNDNMSAIIDLLLSRYGLPDAVFGCNDTAAIRAMEELQARGIKIPEEVSILGFDDIVNSSATTPSLTTFKIFKHEMGVVGSRRLQSLLIGNEPRPTKISLFTEFVQRESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P7</accession>
    <name>I2F6P7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731395.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1955"/>
    <dbReference type="EnsemblBacteria" id="AFK07600">
        <property type="protein sequence ID" value="AFK07600"/>
        <property type="gene ID" value="Theba_1955"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1955"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125830_3_0_0"/>
    <dbReference type="OrthoDB" id="1634402at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="20113" checksum="D944E5E3A766C62F" modified="2012-07-11" version="1">MNAIDYALKLEKDGKAYYTKQAQCSEDIQLKKLFEMLANDEQRHYEIISGFKDKNYKYKGTYTFKTTRNMFSEMLIDKKCFEIDATNLEAYEHAVEMEKESVKLYLDQAKQTSEPSEKEILLKLAAEENKHQIILENLMDFVRKGLDWTESPEFSHLEEWDKFTDLDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q2</accession>
    <name>I2F6Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731400.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1962"/>
    <dbReference type="EnsemblBacteria" id="AFK07605">
        <property type="protein sequence ID" value="AFK07605"/>
        <property type="gene ID" value="Theba_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1962"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_4_2_0"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="272" mass="29451" checksum="A543B615DD9E3879" modified="2012-07-11" version="1">MIKVLVLGGGGAKGFAHVGVIRALEEKGFVPDLIIGVSAGALVGAGYALLSDSKRLWEISLEICRKSKKLIRFANSAARENRGLLFNAATCIHINTFRALPFGLYFNALKKGLKGYRFSDTRIPFKCVSTIMDSGELFVHEEGSIFEALRASMAIPGIISPFSHKGFSLADGGIVNNIPASIAKEEGCTLVVAVDLSSNNRKVGIDTSNSILETIDGYKVEEFQRKELAVADVVISPLNKRNIGLLDFSSCIELMNESYEETLKFDLIGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R7</accession>
    <name>I2F6R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP-type C4-dicarboxylate transport system, large permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731412.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1977"/>
    <dbReference type="EnsemblBacteria" id="AFK07620">
        <property type="protein sequence ID" value="AFK07620"/>
        <property type="gene ID" value="Theba_1977"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1977"/>
    <dbReference type="eggNOG" id="COG4666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645132_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="434" mass="45990" checksum="23EBED7693B96BEE" modified="2012-07-11" version="1">MSADAIYMQTIIAGIVMVGAYAVGKFLKFSTELCMFVAVIGGAIAGGAGFDTFRHIAEGSVTYLDIGLIFVFATIFMNIIKESGGTNYIVRKIIGAFHNKRILMLILLMLVILVPGALTGAGSISVLVVGGTVAAALNAMGLSKVRISALIFIVAGLSAAAPPVNIWAMMTCAGTAIPYVGFTMPLLIPVLILGLFTVLFFGRGAGNIDKEKALKEIPDPKGLSGWSVGVPFLVLIFLLGAPRIWPFDFPVLGLPLVFAICALVAWLMNFKRVDILKVSRETVAQLTPLIATTAVVGMLIQVMSFNGVKGLISMWIVTAPLAIVWILLPFIIPISEGLLTYGGATVIGIPLIWMLNSNGINPVIVLAGLSLLWPLGDGLPPTALIGRLTVSTVGYKGSYGSFLKECVVPWIAITVVAMILVIFANKFNFLMMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T9</accession>
    <name>I2F6T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488054.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1999"/>
    <dbReference type="EnsemblBacteria" id="AFK07642">
        <property type="protein sequence ID" value="AFK07642"/>
        <property type="gene ID" value="Theba_1999"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1999"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_1_3_0"/>
    <dbReference type="OrthoDB" id="992687at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="115"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="29939" checksum="006967BA7C7CCF18" modified="2012-07-11" version="1">MGEEFRITEKLKAMIKGLNPAEKKAARYIIDFPDDVIHHSISELSVLAGTSETTIFRLSKKLNFNGYQALKIQLARELSRESPPISADKNKLISDLIEALNQQNQLIDDVQLDRIAGKIVRANRLIFFGVASSGIVAEFGATLFMRAGFSTAFYTDPHLQIMTAVSLNRGDIVFGISASGNIRDTVKSIEVASDSGAYTVAVTGGIGSRIVSVSTETIYVAQGGHETGIPLLQPRVCQLTVIQLLLEKSIKLRNGTLQTLEKVDRTLDKKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X6</accession>
    <name>I2F6X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731460.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2038"/>
    <dbReference type="EnsemblBacteria" id="AFK07679">
        <property type="protein sequence ID" value="AFK07679"/>
        <property type="gene ID" value="Theba_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2038"/>
    <dbReference type="eggNOG" id="ENOG502Z7HP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053973_0_0_0"/>
    <dbReference type="OrthoDB" id="444212at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009976">
        <property type="term" value="F:tocopherol cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025893">
        <property type="entry name" value="Tocopherol_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309">
        <property type="entry name" value="PTHR35309"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14249">
        <property type="entry name" value="Tocopherol_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="36703" checksum="5A5CDFA85FE060C6" modified="2012-07-11" version="1">MNLYALFNSSLYHGTSSRKGFFEGWYFKFVDRKKEKSFAVIPGVSLNSSREDAHAFVQFLSGGKNESGNFNYPLGEFHSGKKHFSVEISKNHFSAGAVILEMCNENHRIAGNIRILEPYLWPRKFYSPGIMGPFSFVPFMECYHGVVSMDHKLEGEVRIDDELIDLSGGRGYIEKDWGRSFPKAWVWMQSNSFDLERTSFMLSIATIPWLGRSFTGCLCAFLFKEKLYKFATYRGAKIDRVEALDNEVFLQLRQAGFSLNVSAKKTSGARLISPVEGSMSGKIDESLTSEITVRLFRNDAVLFEGTGTNSGLEVVGELKLKEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X9</accession>
    <name>I2F6X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2041"/>
    <dbReference type="EnsemblBacteria" id="AFK07682">
        <property type="protein sequence ID" value="AFK07682"/>
        <property type="gene ID" value="Theba_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2041"/>
    <dbReference type="HOGENOM" id="CLU_3374593_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="34" mass="4021" checksum="02467B6262A79D66" modified="2012-07-11" version="1">MKNKIRGSKSVFIDGLVDKQKIEIESRFSRPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y4</accession>
    <name>I2F6Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium ion-translocating decarboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731467.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2046"/>
    <dbReference type="EnsemblBacteria" id="AFK07687">
        <property type="protein sequence ID" value="AFK07687"/>
        <property type="gene ID" value="Theba_2046"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2046"/>
    <dbReference type="eggNOG" id="COG1883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036168_0_0_0"/>
    <dbReference type="OrthoDB" id="662061at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="365" mass="38912" checksum="600ED54AC6E95B69" modified="2012-07-11" version="1">MNLLSNFSIPVGNLVMFAIGAILIYLAIKKEYEPMLLLPIGFGAILTNIPGSSAIGEHGVLTILYEAGIANELFPALIFIGIGAMIDFGPLLQKPVMFFYGAAAQLGIFLTIIVAALLGFDIREAISIGIIGTADGPTSIYVASRLAIHMLGPISVAAYSYMALVPVVQPPIIKLLTTKEERRIRMDNRTEKVPKYVRVLFPILVTLLAGIIAPVSVALIGMLMFGNLIRESGVLNKLSNAAQNELSNIITLFLGITIGSTMTAEAFLNSRTLLILFMGLVAFVLDTMGGVVFAKILNVFRKQKINPMIGAAGISAFPMSARVVHRMGLDEDPNNFLIMYATGANVAGQIGSVLAGSIVLALFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y9</accession>
    <name>I2F6Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="4">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731472.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2051"/>
    <dbReference type="EnsemblBacteria" id="AFK07692">
        <property type="protein sequence ID" value="AFK07692"/>
        <property type="gene ID" value="Theba_2051"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2051"/>
    <dbReference type="eggNOG" id="COG1866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037428_0_0_0"/>
    <dbReference type="OrthoDB" id="146648at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="550" mass="62221" checksum="83C6B7CEB81956B5" modified="2012-07-11" version="1">MSTSSRFVRERIGRDNPLFSMSRVTIETAFYGNNVVPVVSPSEAYKLAKNSAGTIVTDLPVYKPEKAGLDSDSKVLLFNDGAVTGRCASARRIVGEPGVNETEYGAKLREAVYKTRNRKMYHAQAYIGLDRDFMVKAHLLVPETHENLIYNWLLNFQPINEFYNEMYESSERCENEGDIFVFSDPEWHHPDHPLGLSFFDPEHNCAAILGMRYFGEFKKGTLTLAWGCANRHGFAACHGGQKRYNLQDRKFVVGFFGLSGSGKSTLTHAKHNGKYDVTVLHDDAFVISSSDGSSVALEPSYFDKTSDYPLNSEDNKFLLSVQNVGATQDDEGRIVIVTEDIRNGNGRAIKSKIWSPNRVDKFDEPVEAIIWLMKDPSIPPVVKVNDPVLASVMGATLATKRTSAERLAPGVDPNALVIEPYANPFRTYPLSDDFNRFLELFTHRGINCYIFNTGHFGEKKVPKELTLQILESIVENRAEFLPWEPFEELEIMFIEGFLPDLSDESYKKLLRERLVDRYNFLRSREVERGGFDRLPQEAVESISSLMKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F754</accession>
    <name>I2F754_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487834.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2123"/>
    <dbReference type="EnsemblBacteria" id="AFK07757">
        <property type="protein sequence ID" value="AFK07757"/>
        <property type="gene ID" value="Theba_2123"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2123"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_2_1_0"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="16039" checksum="C1263DF019E37E9C" modified="2012-07-11" version="1">MPDASFRVKAISESAARVSVKARNFTMIVDEPPNLGGEDKGANPVEYVLAALAGCLNVVGHLVADEMGFNIRRLEIDVYGPLNPARLYGKSYEDRAGYKEIIAEMKVDTDAEEETLEKWVKSVEDRCPVSDNLSNPTPVKVIAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F782</accession>
    <name>I2F782_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07785">
        <property type="protein sequence ID" value="AFK07785"/>
        <property type="gene ID" value="Theba_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2152"/>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_3_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="85"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="364" mass="42172" checksum="36E5B78154249F57" modified="2012-07-11" version="1">MQKPTYLTSVEKIEELNDEQITEMKKVTDVYPFRANDYYLGLINWNDPHDPIKRIILPDFEELDEWGDLDASQEHIYTVAPGMEHKYKDTALLLVSKVCGSFCRFCFRKRLFSTENKEVVNDVTLGVEYIRKHKEITNVLLTGGDSLILSTEKLGDIVRQLREIDHVGIIRFGSKMVAFNPYRIINDPDLPDMVKKYSTPKKRIYIMAHFNHPRELTDEAIRGLNILRDAGAVICNQTPMIRGVNDSVEVMTELFRKLSFIGIPPYYVFQCRPTKGNHTYAVPAENGYEIFKKSIDSVSGLAKRARFVMSHATGKIEYVGLDEKKIYMKYHRAADPRRYDLFMAFNRNPDAYWLDDYVDPDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D9</accession>
    <name>I2F7D9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 2</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcvPB</name>
        <name evidence="5" type="ORF">Theba_2211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. C-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731603.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2211"/>
    <dbReference type="EnsemblBacteria" id="AFK07842">
        <property type="protein sequence ID" value="AFK07842"/>
        <property type="gene ID" value="Theba_2211"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2211"/>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_0"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00713">
        <property type="entry name" value="GcvPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023012">
        <property type="entry name" value="GcvPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="482" mass="53327" checksum="0114BB947A505219" modified="2012-07-11" version="1">MTIFELSKEGRKSFFLPKEESYGYEPSELLPEESVRKNEPLLPQLSELQLIRHYTGLSKKNHSVDSGFYPLGSCTMKYNPRVNEKIANLDGFSQIHPYQSEDTVQGALEVMYNLQNSLCEITGMDSFTLQPAAGAHGELVGMLLMKKYFELKGEDNRRKVIVPDSAHGTNPASAVMAGFEVIEVPSGRNGRVDLKSLEEILDESIAGIMLTNPNTLGLFENEICEIQELAHSKGSLLYYDGANLNAIMGHARPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPVGVKSFLADLLPVPVVRFNGRRFSLDYDLPNSIGKVRSFYGNFGVFLKAYAYILTLGGDGLKRASEMAVLNANYLRARLTKLIPTAYAGICMHEFVLKGSKLVSDYGVKTLDVAKRLLDYGIHPPTIYFPLIVEEALMIEPTETESKESLDIFADTFEKILNEAKKDPEILRAAPKFTAVGRLDEATASRKPKTKWSKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F1</accession>
    <name>I2F7F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731613.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2224"/>
    <dbReference type="EnsemblBacteria" id="AFK07854">
        <property type="protein sequence ID" value="AFK07854"/>
        <property type="gene ID" value="Theba_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2224"/>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694047_0_0_0"/>
    <dbReference type="OrthoDB" id="801007at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="269"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="397" mass="45856" checksum="25B6CAAD23235A6E" modified="2012-07-11" version="1">MINEELMERAVFELGKDSPFYNFLLLFIDRIPSVAVRTLKLRVSSRGRFQLLYNPDTLRNKPLAFTKALLKHECLHIVNGHILIPVSKSREKMLWDLSMDAAVNQFIRELDAFSLPMDSILKEGCGTDNERFFVGPPMQYPGMTAEFYHDWGLDFMKKNKTIDLELLDSNISRPDSHEDFGKFELPKEFVEDLLKQVISETMEKAKTGMPEGLEGVMKLVLDNPVLDWRNMIRRFFGSSMQVGRYRTPMRPNRRYDDQPGWRNDYAAKLVVVVDTSGSIIEEEFNSFFSEIDEVTRVTDSRVWLVQVDETVQSVMKYGKGMWRDLKLMGRGETDLQPAVDYAQEKLRPEGLLLFTDGFTDLPTVSRRVLFVLPKSHNSDFAEEAKSIYGRSSVVFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K3</accession>
    <name>I2F7K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731665.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07906">
        <property type="protein sequence ID" value="AFK07906"/>
        <property type="gene ID" value="Theba_2277"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2277"/>
    <dbReference type="HOGENOM" id="CLU_2753185_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="70" mass="8058" checksum="0524AC6148F8A591" modified="2012-07-11" version="1">MREERLSLAVGNVYKVKNTFDSIGAKELYEVFVAFQKTVAGERGEEIPALEKRFTLLLRKLLEEIGRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K9</accession>
    <name>I2F7K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487577.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2284"/>
    <dbReference type="EnsemblBacteria" id="AFK07912">
        <property type="protein sequence ID" value="AFK07912"/>
        <property type="gene ID" value="Theba_2284"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2284"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="99"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="326" mass="35792" checksum="F78343845B4BAED9" modified="2012-07-11" version="1" precursor="true">MAYFARKIGLLLFALFVAVTLNFFIPRMMPGDPAQDLMDKMQGIPLESLEAIKAAFGVDSTDPLLLQYGKYLLNLIKGDLGISISRFPTPVGRVLQVAVPWTVGLMGTATIISFFLGTIIGIGVAWKRNTKLASFTVGLFIFVRSFPYFWLGLLLIYFLAFRIPIFPLGNAYTPQLERGTLEFFLSVVKHAILPALTIVISSMGAWILTMRNNMINVLAEDYITVAEAKGLPLRRIKTLYAAKNAILPSITGFAMSLGFVVGGGLLTEMVFSYPGVGLMLYQAVQSKDYPLMQAIFLFISVAVLVANFIADIAVLILDPRVRDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M4</accession>
    <name>I2F7M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR type III-B/RAMP module RAMP protein Cmr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731682.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2299"/>
    <dbReference type="EnsemblBacteria" id="AFK07927">
        <property type="protein sequence ID" value="AFK07927"/>
        <property type="gene ID" value="Theba_2299"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2299"/>
    <dbReference type="eggNOG" id="COG1336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047795_1_0_0"/>
    <dbReference type="OrthoDB" id="972874at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013410">
        <property type="entry name" value="CRISPR-assoc_RAMP_Cmr4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
        <property type="entry name" value="PTHR36700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="34194" checksum="136783A49063B635" modified="2012-07-11" version="1">MSNELYSEEKFIFMTLDPIHIGTGGTNLGIVDNTIIREAGSNIPIIPGTSLSGAAKMYAAMLMGDLDAAGSKKPKSTENPVSYTFGYINSSGSKQTSKAGVVSFSDARIVLFPVCSSEGTIWVTTRAMLNEIGFDMKDLGPDEEKAYHLGGTDENSKIKIGWLFIDVENITIEKPKLGGLAEKDEWKVVEQKIYIVSDKLFTQIVNDNLETRTSVAINPETGAAEDQALFTYEAIPRATWLISAVIQDDYKIEGFSDSMKEDKYKENGKINCWKSPMDVVRAGFKIIEFMGIGGMTTRGFGRMKIISGGDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M5</accession>
    <name>I2F7M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731683.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2300"/>
    <dbReference type="EnsemblBacteria" id="AFK07928">
        <property type="protein sequence ID" value="AFK07928"/>
        <property type="gene ID" value="Theba_2300"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2300"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007515_0_0_0"/>
    <dbReference type="OrthoDB" id="140901at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1005" mass="115502" checksum="69C075257C904C49" modified="2012-07-11" version="1">MTKSLKILKDNRDNLLKIELAGWLHDMYKCSDEHVDKQSVEPVLSMNVGKAFYFGLMNDFDISFKGSLKESVRVTELIEKGRPGKTTMEDKNLSLLVKYLGRCHGAAHIEKEESKTSLESAELKELMKNKNDSKRKLKNVQRSLSDKEKNADSVLRKHGFVNPELVAKIEEDKAKIKLISNELQDIENMINLVSKKQKVDSVKQNRHDTFISSIFGYESRIVSNLTARFKEILDNSKPPEYGDVGAISRVFSEALGDTRRPANEITLEDWSFIVATLFKSAVAGALLETENGREPVSADKLRWRFLSVRISGEQALGNSTSISDLLARKNWINEGLSRVKKLLEEEYPLGNEVYRDENGSIFVVPDIEDILEYVLDDTTETLEKRIRVKLDFRGEITPEIAISEPWWGQKPILPSGISPEAWQEGDKIPPIGTIISKQPFSPADPEEISTYWSQNQRNQICRISWLRPEEDKTRHVSEFWASEIKGRAETWLKEKNTTIWIDEIADSNSKIALVSAKLAISNWIGEEPGKLSLIRTLNYETPPVSKHFEKCAKTPSFARVRRVWETTSKFWDEALAEIKEVIDPITERLVLKVRTNNLSLPTNNAYEAKVNETKFNETKFTETKFTVFYENKNPKGADGLENFVIIENLELLAKKLPVEIKTDSRKDLVDALLEGLKGKNIDFFNSNDPSVVLASSRIDGIEIESCNYTPVIEITKDPERFMVLVPADKALEAAKKIKEKYEREMGKVRNRLPMNLGIVYAGYHTALPAIMDAGRRMMQIDNEEKTWILMKQPEELSDYFELTFQGNQFWKIPSKMGDCSEDVWYPYFYVLNAEAKPEKRLLSFKGPSGNWLVHVSELKEGDIVQVTPSYFDFEYLSSASQRFEISYTNDCRRRSNDRKQRPYYLDDLDEIERVWAIISTKLSNSQIKKLNTLVEEKRRDWALSTENEDDTFNSYVENVVENLKWKQPLSKHEKEKLVDFCVNGKFVDVLEIHMSIMKDKSEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T8</accession>
    <name>I2F7T8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Prephenate dehydratase</fullName>
            <shortName evidence="9">PDT</shortName>
            <ecNumber evidence="3 9">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="12" type="ORF">Theba_2370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2370"/>
    <dbReference type="EnsemblBacteria" id="AFK07991">
        <property type="protein sequence ID" value="AFK07991"/>
        <property type="gene ID" value="Theba_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2370"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_4_2_0"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="32865" checksum="00004DF3DD1BE506" modified="2012-07-11" version="1">MPHEQGSSLKRSIVFQGEHGAYSEQAIRKLFGESPTTIPCRSFREMLKLVSEEKVDCAMLPVENSLAGTVIPAYDALIESELFVHAEVMLRIEHCLMAPEGVKIEDIRYVISHHQALSQCMRHIEEEGFEAKEYYDTAGSARDLATLKMPFTAAIASELAAKTYGLEILRMGFEDLDTNTTRFFLMGREARKCEGRCKTSMIFTTEHKPGALFKVLGELSDRNLNLTKIESRPFTKEMWHYLFFVDFEGSVSEKRVEEAVNAISSRCSYFKLLGSYRSANDVELNSNQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U1</accession>
    <name>I2F7U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2374"/>
    <dbReference type="EnsemblBacteria" id="AFK07994">
        <property type="protein sequence ID" value="AFK07994"/>
        <property type="gene ID" value="Theba_2374"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2374"/>
    <dbReference type="eggNOG" id="ENOG502Z9MX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1268232at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="44000" checksum="B55E521F36B7E84B" modified="2012-07-11" version="1" precursor="true">MNLTKVFSESELSLEVVILMIAGLILLITGILLFPVATGGLPYYENGLYGLLLVMFSLQIISMGKTPFGDLRRSKFVVLAGLIVGGIGTITCFIPDAFNDIPRLLLFLFFGPGGALLLLQMILSKDKLKAWSKYGGIFKHLIAGCTVAYVSSILISVLLWNQSLLSVQMTAILVLIYGVAVVYLSFVLRKIYSTYPQEQKSKDGEVELPIDRAMILFTSVFMIILGVLLIPVNLGLLPFSGSAQLGLLMMIFAIQMIASGSTPIGVFPRSLPVILIGFVFAALGTVSCIIPEVLVYPLTVLVGVLNILGGAISIGKFLGRRVSSTDQQKGKIPKILVKLNVSQLILNVLAIAFGLSMLISHLLPGLVIGVVLAANGVVLLYLLYILFIIDRIQKEMGTESSLEIYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U2</accession>
    <name>I2F7U2_9BACT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_2375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    </dbReference>
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        <property type="gene ID" value="Theba_2375"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="268" mass="30122" checksum="85790CF96408C583" modified="2012-07-11" version="1" precursor="true">MNGYFEKKVAVVTGAASGIGLGLAEGMLSRGAKAVFMADVSQENLDRESERLNSKYEGEAVPFLTDVTKEEQVEKIIKSARKYEGHLDFVFNNAGIGMTIPTEMVTLEIWKNLIDINLWGVIYGTYQAIPIMREQKSGHIVNTASIAGLVPVPYQALYAGTKSAVKTITESLYYELQNEGLRFSVVCPGNVRTAIFRGLTPPPDSVSVEEAVSYIFEKMEKGDLLIVFPQKYRDFDEMYRTDREKFDEFALNLAAERLENYRTKGNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V6</accession>
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        <submittedName>
            <fullName evidence="3">Phytoene dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">Theba_2391</name>
    </gene>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2391"/>
    <dbReference type="EnsemblBacteria" id="AFK08009">
        <property type="protein sequence ID" value="AFK08009"/>
        <property type="gene ID" value="Theba_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2391"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_3_0_0"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="490" mass="55166" checksum="9DAAE9262B5D4445" modified="2012-07-11" version="1" precursor="true">MSKIAIIGSGIGGLAAGCYARMNGLESVILEKADKPGGLCTSWDKGDYIFDGCIRHLAGLKPGTPLNNMWKDIGAMPSDIYFPEELVKAVDEKGNELTVFYDLEKLEAEMKRISPEDSELIEDYIRAIRRLSNTDLMEVGFWGFRDWLRNISVLIKNRKVSKYSMLSFAQRFKSPVLREFFPVIQYGWANIPLTLNLGVMAGSVGKRYGRYLGGSAEFIKSVADRYSSLGGEILYNSSVERIIEDSGKAVGVRLENGTEISANYVISDAYGYDTFMKMIDERHLTDRLRSMYSKPIDRMMMGLHVSFGVNMDLSDKPNTISFFLDEPIEIAGDNCSIINLLNYSYDKKLAPKGKTSIKAMYDTYYSYWEELSKDQKKYEEEKAIIASRTIEAIERFIPGIGEAVEATDVATPITTERFTSNARGYGSKEDFRLRDTLKGFLNKPMTLKSLKNFFVIGHSIGGTNLYGCAAMGRNTIRRICKMEHRNFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W4</accession>
    <name>I2F7W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731759.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2399"/>
    <dbReference type="EnsemblBacteria" id="AFK08017">
        <property type="protein sequence ID" value="AFK08017"/>
        <property type="gene ID" value="Theba_2399"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2399"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_0_1_0"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="196" mass="22415" checksum="1471357FEA819249" modified="2012-07-11" version="1">MNLKGSETVENLMKAFAGESQARNRYTFYASVAKKEGFEQISAIFKETADNEKEHAEVFFKHIIDGMKDELPVMVHVDADYPVDLRGTKENLKAAAAGENEEWTKLYPTFADVAEKEGFLDVANSFRQIAKVESRHEARYLKLLENVETGKVFKREEKVLWKCGNCGYILEAKEAPEQCPACKHPKAYFELFVENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X4</accession>
    <name>I2F7X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731768.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2410"/>
    <dbReference type="EnsemblBacteria" id="AFK08027">
        <property type="protein sequence ID" value="AFK08027"/>
        <property type="gene ID" value="Theba_2410"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2410"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_6_0"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="112"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="480" mass="52277" checksum="3206A3F5E89A6295" modified="2012-07-11" version="1" precursor="true">MIALVFLPVLGGVICLVLKKRKNVSLIIAIVTALVGGSVLPFVIFDNASIDIGNWGSLGIGLAIDELAIPFLLSTFIVMLAVILNSIKKGYDGFFYALILILYGTLNSIFLSRDLFSIFVTVELASIISFILISYEKKPRQAWASLKYLLLSSLGLNFYLLGIGIVYMETGSFAMDSLEQVSTIATVLIFGGLAVKSGLFFFSMWLPDAHSNAPIEVSPILSGLIVKLDVYLSIRFITYSSFGWMRDTYMFIGIVSAIVGVVFAVNSKNAKRVLAYHTISQVGFMLVNCDKSSAWHGFSHAIFKTLLFLVVGNISERLGTKEYTKWSGKITRVEYAFLLIGSLAIAGFPMTSGCVTKEIIIHGACCPSLKILLLIASAGTAMSFSKFIFLKPGKSSSRPAANTVAAYSILSGVIIVHGIIGFEIYMFESLFAVIAGVAAYLLLRKFLRPLPVYFERIDSALSSYLVLFLISIVLAIILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y2</accession>
    <name>I2F7Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731774.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2419"/>
    <dbReference type="EnsemblBacteria" id="AFK08035">
        <property type="protein sequence ID" value="AFK08035"/>
        <property type="gene ID" value="Theba_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2419"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="38530" checksum="BD82654E556DAE0D" modified="2012-07-11" version="1">MNENIIEVKDLQKWFPIRRNISQFFKGEHNYVKAVDGVSFSIKRGEIFGLVGESGCGKTTTGKLIMKLLEPTGGTMFLNGKDVTHIEKDELKIYRRNVQMIFQDPYASMNPRFKIRDVMEEPLIIHKLGEDRDERMKMIEKALREVKLNPPDEFLVRYPHMLSGGQRQRAATARTLLLNPELLVADEPVSMIDLSTRAEILHMMKEVQRDLGLTYLYITHDLSTARYFTDRIAVMYLGKIIEIGDPDDVIDNPVHPYTRALIAAVCEPVAGKVNKPKIVPIKGEIPSAANIPKGCRFHPRCPYAKEECWEKEEPQLQEIEDGHFHACRRWKEVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F833</accession>
    <name>I2F833_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731818.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2475"/>
    <dbReference type="EnsemblBacteria" id="AFK08086">
        <property type="protein sequence ID" value="AFK08086"/>
        <property type="gene ID" value="Theba_2475"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2475"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="301" mass="34164" checksum="BE54CFE8D15E0388" modified="2012-07-11" version="1" precursor="true">MNVPRLNRKVKTAAGIASVYFTLLLIGFVFIYPVIYIVSYSFMDTEDLVNPLVRWLPTKLYIGNFSEAASVLDFAPTLMKTLIVTVLPSILQTISASIVGYGFSRFRFPGKKIMLAALLATFIIPPQVTMIPQFLMFRDLKLLETIWAFILPATFTQGIRSAIFVLIFYQFFNMLPRSLEEAAKIDGASTFKIFYRIAVPSATPAYIIAFLFSLVWYWNETTLTALYLGEKWATLPLKLQNFAVTFRRLYPADPYSVVGKNLNEAIVMAGTFLTLIPLLMIYFFTQSWFVESIDRTGITGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F872</accession>
    <name>I2F872_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2520"/>
    <dbReference type="EnsemblBacteria" id="AFK08125">
        <property type="protein sequence ID" value="AFK08125"/>
        <property type="gene ID" value="Theba_2520"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2520"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="280" mass="32064" checksum="C5556A7E6F2F695F" modified="2012-07-11" version="1" precursor="true">MRKIKLLMLVSMLTYLYIFARSLDDSSFVRVRRGKFVMGDLSQSGFDNEWSPHFVNISHDFLISKYETTFSEFDEFCAETGREKSPDNGWGRRERPVIFVSWWDAVEYCNWLSEKQGLPPAYNSLGDLIDVKGEIVSSPSKAVGYRLPTEAEWEYAARGGDSAGDTIYSGHDQPGVVAWYNLNSDWKTSEVGMKEPNEIGIYDMSGNVWEWCFDWYESYPDSEQSDPCVLSKGNYRVIRGGSWHDFERYLRVSARSAYTPTGAAYDVGFRVCRTLCSVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A4</accession>
    <name>I2F8A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489483.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2557"/>
    <dbReference type="EnsemblBacteria" id="AFK08157">
        <property type="protein sequence ID" value="AFK08157"/>
        <property type="gene ID" value="Theba_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2557"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="29301" checksum="25BE2EC0A4ADA087" modified="2012-07-11" version="1">MSLLTLENVTMKFGGLTAVKDVTLRVEEGEIFGLIGPNGAGKTTIFNMITGHYKPTDGRILFRENEITALQPDKITRTGIARTFQNIRLFRDLTVLENVMVSQHHTIASNGKAVSWFFKSVTRLGYSEKEREMRNKALELLSVLGLEMLANEKSSALSYGSQRLLEIARAMATGATLLLLDEPAAGMNASETAGLVDTIRRIRDDFGLTVLLIEHDMKLVMGLCERIMVLDHGRTISEGDPAFVQKDVRVIEAYLGREWVTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A5</accession>
    <name>I2F8A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489481.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2558"/>
    <dbReference type="EnsemblBacteria" id="AFK08158">
        <property type="protein sequence ID" value="AFK08158"/>
        <property type="gene ID" value="Theba_2558"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2558"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="25481" checksum="1FD722CCF3C875C8" modified="2012-07-11" version="1">MANEILSVDELQVSYGVIKAVKGITLSVEEGSIVTIIGSNGAGKSTTLGAVSGLIRPSGGKVSFRGNNINRLGAARTAKLGISLVPEGRRIFSNLTVRENLLMGAYNRKDKEEIEGNFEAVFSLFPVLKERLKQSGGTLSGGEQQMLAIGRSLMANPDLIMMDEPSLGLAPIVVEEVFQAIQTLNSRGVTILLVEQNAAKALEISKYAYVLETGKITLQGSAKELLESEEVRKVYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A9</accession>
    <name>I2F8A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="gene ID" value="Theba_2562"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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            <end position="64"/>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="66" mass="7255" checksum="1D419E9F5013A6E7" modified="2012-07-11" version="1">MTGTVKWFNGTKGYGFITKDDGGDVFVHFSAIEMDGFKTLDEGQRVEFEVEDGPKGPQAAKVRIAK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Bruce D."/>
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                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
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                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK08244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="228" mass="26048" checksum="3F10C75A2508C03D" modified="2012-07-11" version="1">MKLLVVEDEKKLLENVAAFLERKGFLVDTAQDAEDGLDLALERNYDCIILDVILPGMGGYEFCRFLREEIGSDVPIIIITALGEIDSRIEGLKIGADDYLPKPFDLRELEARVRALIRRNQLRSEPVIRYGPLTYDSRSGVFSCSKKELSLTSRESSILELFLRNPGTVFSREEITDKIWETGFESRSNIVDVYIRYIRRKLEAAGILDIIQTVPRKGYGLRRLRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J8</accession>
    <name>I2F8J8_9BACT</name>
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        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">Theba_2651</name>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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            <authorList>
                <person name="Zhaxybayeva O."/>
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                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
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                <person name="Land M.L."/>
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                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="TM_effector"/>
    </dbReference>
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        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="423" mass="45851" checksum="FF2D1040B64E64EA" modified="2012-07-11" version="1" precursor="true">MANSLLCLLHSRMGRAFPALKVKNFRYFWIGQLISVMGTWMQTAAQSWLVLTITDSPFLLGLLGVAQFTPVLLFSLPAGVFVDRFPKRSIVLLTQTISMILALILAILVFTDSVQYWHIFLLALGLGMVKTLDIPARQSFMIELVGRDVVLNAVALNSTVMNLGRVVGPAVAGVVMALVGAGWCFLVNGVTFLAVIFGLLKIDVEPVIKKRPKGTVIPDIKEGLVYLFSKPILTTTTLILAIVSTFGMNYSVLIPVFARNQLGLDAQGYGLLMSALGVGSMLGALIVASSSSRGPNRVRLFVVPFITSSLFMIMAFNRSYAFSALLIGLMGFANIFFTTTANSLMQINSDNEFRGRVMSVYSLVFAGSTPIGNMFVGSIADKAGGGSAFFWAGVVTFFLVAATIIAHKIRKRSVRVKPEQHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L2</accession>
    <name>I2F8L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487278.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2666"/>
    <dbReference type="EnsemblBacteria" id="AFK08265">
        <property type="protein sequence ID" value="AFK08265"/>
        <property type="gene ID" value="Theba_2666"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2666"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_2_0"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="138" mass="16132" checksum="6793CF60789B2549" modified="2012-07-11" version="1">MKSYRKELFFNTKMRREIINITDDVEGALLESGIREGLVLVNAMHITASVFINDNESGLHQDFERWLERLAPEKPYSQYEHNGFEDNADAHLKRTVMGREVVIAVTEGKLDFGPWEQVFYYELDGKRRKRVLIKIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R8</accession>
    <name>I2F8R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732014.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2726"/>
    <dbReference type="EnsemblBacteria" id="AFK08321">
        <property type="protein sequence ID" value="AFK08321"/>
        <property type="gene ID" value="Theba_2726"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2726"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_4_0"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="405" mass="46541" checksum="31BCA3FE57718449" modified="2012-07-11" version="1" precursor="true">MKRVLLVILFVSVALVGLGIQQLVVNSYMSDPEPKRVFEELVQQFESMYPDFEVTVNTFAHEDFKVLLRTWLTSSNPPDVVTWFAGERMRYFASKDLLEPIGDIFENGFEADFPKAFVSASSYEDRIYFLPQSWYWWGVYYRKSVFEELGITVPLTWKQFLDVCETLKANDMIPITIGTKYLWTAAGVFDYLNMRVNGIDYALKLTNGEIPYTDDGMKAVFEYWKQLVENGYFIEDATSYTWQEAATYLFTGEAGMYLMGQFIKDVAPPDVKDDLDFFRFPIIDGNLGLYEDTPIDGFMMPANAKNKEAGKTFLKFIASKEAQEYFATELGRLAANKHVPAPDDHAKKGLEMILSSDGVMQFYDRDTDPEMANAGMNGFVEFMTFPSRLDTILKNLEAERNRIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S0</accession>
    <name>I2F8S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732016.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2728"/>
    <dbReference type="EnsemblBacteria" id="AFK08323">
        <property type="protein sequence ID" value="AFK08323"/>
        <property type="gene ID" value="Theba_2728"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2728"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="272" mass="31200" checksum="2717D52092F5303A" modified="2012-07-11" version="1" precursor="true">MKRTLFYIFATLLVLVWLMPFVITMFTSVKSMDELMMGRRWWEPPKELRFENYATAWQDANMGRYFMNTFIITVPSVLGALFLSSLGAFALAWYDFRLSKTILMIFVGGMLIPFQMLLIPVYRMSISFGIYDSYIGVILFHIAFQLGFCTFFLRNFMKTIPASIFDAAMIDGAGHFLIYRRIVLPLVVPAMAALGILEFTWIWNDYLWSLILIQSDRFKPVTLGLVNLQGQWITSWNVMAAGSIIAAVVPLVVFLLFQRYFIEGLTVGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H2</accession>
    <name>I2F1H2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="10" type="ORF">Theba_0020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729955.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0020"/>
    <dbReference type="EnsemblBacteria" id="AFK05775">
        <property type="protein sequence ID" value="AFK05775"/>
        <property type="gene ID" value="Theba_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0020"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_0"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="17973" checksum="FC3057CAF29B1160" modified="2012-07-11" version="1">MKCPFCGGDSTRVLDSRPTDENTSIRRRRECEKCGARFTTYERYERLPFLVVKKDGRREKFSREKLLNGLLRACEKRPISVDTVNEIVDSVENEVVKSGKHEVVSSEIGEMVMTKLKSLDRVAYVRFASVYKEFRDLDHFMDIIEELRDDRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H3</accession>
    <name>I2F1H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ORF">Theba_0021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0021"/>
    <dbReference type="EnsemblBacteria" id="AFK05776">
        <property type="protein sequence ID" value="AFK05776"/>
        <property type="gene ID" value="Theba_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0021"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK05776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="17874" checksum="69B5946142150938" modified="2012-07-11" version="1">MKKKVIYLTQEGFNGMKEELESLRKKLMYDIAERIKEARELGDLSENSEYDEAKNEQGRIDSRIKQLEEILNNAEIIEDDGDLSTVKLGYVVELLNIDTNEKSQFRIVNAQEANIFEGKISSDSPIGRGVLTHKVNEVVRVKTPAGWAKYKILTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M0</accession>
    <name>I2F1M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729996.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0072"/>
    <dbReference type="EnsemblBacteria" id="AFK05823">
        <property type="protein sequence ID" value="AFK05823"/>
        <property type="gene ID" value="Theba_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0072"/>
    <dbReference type="eggNOG" id="COG1738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075503_2_1_0"/>
    <dbReference type="OrthoDB" id="1462872at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="231" mass="26476" checksum="16F0A6BD790DE095" modified="2012-07-11" version="1" precursor="true">MNEILWFVMLVVNFALITIAYRWWGKTGLYVWVAIAAIIANVQVIKTVSLFWMAATLGNIVYATSFLATDILSENHGKKEARKAVYIGFFSLISVTVIMQIALAFEPHPSDFSQEHLSVVFGLLPRIALASLAAYWCSQLHDVWAYDFWKKRFPEKRHIWIRNNASTMISQLIDTAVFTVIAFAGVFSAGVWWQIFWSTYILKWVVAVLDTPFIYLARKMKDDGKIRDLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S3</accession>
    <name>I2F1S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730041.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0129"/>
    <dbReference type="EnsemblBacteria" id="AFK05876">
        <property type="protein sequence ID" value="AFK05876"/>
        <property type="gene ID" value="Theba_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0129"/>
    <dbReference type="eggNOG" id="ENOG50305F3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530024_0_0_0"/>
    <dbReference type="OrthoDB" id="1700311at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="175" mass="20016" checksum="66B1AEA8AB8413A4" modified="2012-07-11" version="1">MPRLRKMLNDLNASYIKLLMRQIETQSKTTLANWAIDYSERIILPLWLKYCPDDLRPKFALDSARLWLNGKIQFQQAKKKILRCHEAAREAESNHVAHIAARAIAQSASTIHAARHCIGLALYGALAVAYDELGTEAPWERLEIRAEQECEHMLAALCEISVVDEPNPANIDWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U4</accession>
    <name>I2F1U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-dependent oxidoreductase, alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730062.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0155"/>
    <dbReference type="EnsemblBacteria" id="AFK05897">
        <property type="protein sequence ID" value="AFK05897"/>
        <property type="gene ID" value="Theba_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0155"/>
    <dbReference type="eggNOG" id="COG1979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_0"/>
    <dbReference type="OrthoDB" id="717704at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="10"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="42919" checksum="2334FBF4C9443B62" modified="2012-07-11" version="1">MLDFTFHNATKIIFGRNTEKKVGEEISKLGKKVLFHYGGGSIKKTGIYDRVVESLKKAGVEIFELGGVKPNPRLSLVKEGIELCRKNGIDAILAVGGGSVIDSAKAIGIGVPYEGDVWDFYSKGKKVEEMLPLGVVLTIPAAGSESSGGSVITNEDGWYKRSTNSVNMRAKFAIMNPELTFTLPNYQTAVGAVDIMSHVMERYFTNVKNVDFTDRLCEATLRTMIRNTPIALKEPENYDARAEIMWAGTIAHNDLLSTGRIGDWATHGMEHELSAIYDIAHGGGLAIMWAPWMTYVYKHDIERFAQFAYRVWDVEPDFRNPEKAALEGIKGLKEFFASLGIPVTLTDAGIPDDRFDEMAKKATEDGPLGQFVKLYKDDVKKIYELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V9</accession>
    <name>I2F1V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730076.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05912">
        <property type="protein sequence ID" value="AFK05912"/>
        <property type="gene ID" value="Theba_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0172"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101329_0_0_0"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="196" mass="23017" checksum="32F0E6F671A5AC9E" modified="2012-07-11" version="1">MEHNESLVKRRSIRLKEYDYSRTGAYFLTICTHRRQCLLGSMVDSRVILSSIGKIVVEEWLRSAEVRKEIELDAFVIMPNHLHGIVAIHGGEREIVSNCLEAERRTIKPKTIGSFVSGFKAAATVRVNELRGTPGKSIWQRNYYEHVIRNEKELNRIREYIENNPLRWQIDRENPYRKTSQVLSTIEEDDLYPWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y8</accession>
    <name>I2F1Y8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">Theba_0206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730104.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0206"/>
    <dbReference type="EnsemblBacteria" id="AFK05941">
        <property type="protein sequence ID" value="AFK05941"/>
        <property type="gene ID" value="Theba_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0206"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_0"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008771">
        <property type="term" value="F:[citrate (pro-3S)-lyase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00764">
        <property type="entry name" value="Citrate_ly_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Citrate_ly_lig" evidence="7">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK05941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="158" mass="17973" checksum="791725AB2E9D74B9" modified="2012-07-11" version="1">MKAVYPGSFDPITYGHIDLVERCSKIFDEVLVLVMENVNKKHFFSHEERIEMVRCGVSHLENVTIITYSGLLVDFAKANDVKIIIRGLRAVSDFELELQMAHANKAMLQELETLFLMTDTSNSFISSSMVREIAAFGGDISKWVPPCVQEEFRRKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z7</accession>
    <name>I2F1Z7_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">Theba_0216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="Theba_0216"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK05950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="399" mass="44592" checksum="C92CB6974B9ACF26" modified="2012-07-11" version="1" precursor="true">MSNDNKSKLLLRTDNLVKYFPVKAGVFRRVVAQVKAVDDVSFSVYEKETLGLVGESGCGKTTAGMTVLRLYEPTSGRIIVGDEDTTHFFMPSLKARKYIKQTYIEKFSDLKEKSGSVEGAISSIEDGFDKKMAEKYFKEFNEDAGEFVKSLLGNREEKRKAFRRDAQIIFQDPFSSLNPRMRVKNIIGEGARIHGLATGRDVMDKVADIMTKVGLSKDHMSRFPHEFSGGQRQRIGVARALILNPRLIVCDEAVSALDVSIQAQILNLLSDLQKDFGLTYLFIAHDLGVVKHVSKRVAVMYLGKIAELADKKKLFDNPLHPYTVSLMSAIPEANPEKKKQRILLEGDVPSPINPPTGCRFHPRCPIAKDICSKEEPKLQDIGGGHYVSCFFPGELKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F249</accession>
    <name>I2F249_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">Theba_0269</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="Theba_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0269"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155232_0_0_0"/>
    <dbReference type="OrthoDB" id="1069317at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="27922" checksum="C94516262FC9FAB7" modified="2012-07-11" version="1" precursor="true">MKKMLVIIFLIVFSSVFFASEYEALLSEFVQIRAMEDTEMMAEFIEKLESEDLEDIEILTLLADCHREYANWIEDKKTRETHYNKARELAEQAIKMDDSYGMAYYVKGAAIGQLAQMAGIIQSMFLISDFDKSIDKAMELMPDSPFPFIAKGMRDRDTPWPYRNYGKSEERFMKAIENDPGYLNSYYELAVLYQVWKKKDLAAQYYRKVLELELQPDFIVQGQEAKENAQKWLEDNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A8</accession>
    <name>I2F2A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730202.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0332"/>
    <dbReference type="EnsemblBacteria" id="AFK06061">
        <property type="protein sequence ID" value="AFK06061"/>
        <property type="gene ID" value="Theba_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0332"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053520_0_0_0"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="342" mass="37326" checksum="87D5DD46EAA05320" modified="2012-07-11" version="1">MNYSELYIVKELVDLVNIPSPSGFTDSIIGYLDSELKRLGFSPRRTRKGALVVEIGGRGNPIVLAAHVDTLGAMVKSLKPNGRLEITNVGGFTMNSIENENCIIHSKTGKTFSGTIQSISPSVHVFENARSLERKIANMEIRVDEELKNAEDLQKLGIEAGDFVSFDPRATVTKNGFVKSRHLDDKASVAVLLDFARRVSEGKVTCSRKTYLFFSNYEEVGHGASAAMPDDSEEIISVDMGAVGDTLRTDEYVVSICAKDSGGPYDSTVVRSLIESAKRVGADYSVDIYPFYGSDVEASLRAGYDVRFGLIGPGVEASHGYERTHYKALENTLKLIEGYVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B5</accession>
    <name>I2F2B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730207.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0339"/>
    <dbReference type="EnsemblBacteria" id="AFK06068">
        <property type="protein sequence ID" value="AFK06068"/>
        <property type="gene ID" value="Theba_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0339"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_0"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="392" mass="43633" checksum="0DE69FF43ADB3ED7" modified="2012-07-11" version="1">MSARVVLKRSIKRRIAFGHPWIYDNEIEKADSVEGGCIVDVLTNSGQFLGRGYYNPDSSIRVRLLTRRNCSIDTDFFAQKLKRSLAMKSSLLRYGNALRVTFGEADGLPGLIVDKFSDWLVVQFNTLGIGVLKNEIIEALIATLKPKGIFEKSEGISLTKEGLESKEGWLFGNGPELLPFSLNGVTFFADTKGQKTGFFLDQRDNAEKLSKYANGRNVLDVFSYTGNFSFHCLSQGASRATLVDSSERALSVARETAEINGFISRCEFVRANAFDYLREESLAGHSLVIVDPPAMAKSPSSKKSALRGYKELNLRVIKKAVSGSLLASSSCTQIISEDDWMRTINDAFHDSKKVGIVSFRGGQPLDHPEVSSIFETRYLKFCLFRVFELCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C3</accession>
    <name>I2F2C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730212.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0347"/>
    <dbReference type="EnsemblBacteria" id="AFK06076">
        <property type="protein sequence ID" value="AFK06076"/>
        <property type="gene ID" value="Theba_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0347"/>
    <dbReference type="HOGENOM" id="CLU_616492_0_0_0"/>
    <dbReference type="OrthoDB" id="1664413at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="444" mass="48449" checksum="864623922E0039A8" modified="2012-07-11" version="1" precursor="true">MRRFMVLALLVIGALSVASVGTMSGRLPAQSHTVLIVEDLENNYNVSKKAVLMDMVLNQLAIEQLIAQYVEMLAYNNGLDPKDIYKAFDGDLGLAVWVDSEGTDRLVIVLGPTENPKALKAAIEKILPQLLPSEIELNIAVDQEYLFIGDIEQYAVTEKGFNLSLVTEGLTPGFAYFYSSVGDVVQKGSLWNEEGILIAEALSVPLSEETRERFSSALEGASVVELEAGYHLPLVSGFAKINDLSFLSDLNIEQLGLLPLELGELKIGTQDITEFSEEMTGEIMVDANISVDDIFASLMGSEGTTSGATDSVGYSYVLRAGYSGTLDDLKFRLEKADPDLKILVIENGLSIEDQYIWVSDGWLYVSSSNQVKITKELQEGAIVSDLEVYNELLKFSGSEGFARLFLDSGYILTGLMGVEIESGVLVNSQYVREIGGIRSTIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F6</accession>
    <name>I2F2F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730232.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0381"/>
    <dbReference type="EnsemblBacteria" id="AFK06109">
        <property type="protein sequence ID" value="AFK06109"/>
        <property type="gene ID" value="Theba_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0381"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_0"/>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="433" mass="46922" checksum="26BD6F20F978534A" modified="2012-07-11" version="1">MRIYDIIMKKRNGFPNTREELDSLIMGFVEGIVPDYQMAAWLMAVYFNHLNAEERFHLTEIMIESGDRIDLSSIKGRKIDKHSTGGVGDKVTLVVGPIVAAAGLVFAKLSGRGLGHTGGTIDKLESIPGFVTSLDIEQFKRQAERIGIALAGQTAQVAVADKKLYALRDLTATVDEISLIASSIMSKKLAVDSDGILLDVKIGTGAFMKDLDGAKTLARAMIDLGRKNGRATKAVISDMNQPLGVSVGNSLEVVEAIDTLKGRGPQDFSSLCRIIAGQMLVAGGMKSEADALRTVDRLILSGEALRKFDEFVYAQGGPEGFSASYAVHFKEAEIVEEVRTSVSGYVQSVDAESIGLICMRLGAGRERKEDVIDPSVGIRILKRIGDRVEKDEVIAVIYANDKRNADNEAKKLVDSFVISEQKTSPPPIVYEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G6</accession>
    <name>I2F2G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730238.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0391"/>
    <dbReference type="EnsemblBacteria" id="AFK06119">
        <property type="protein sequence ID" value="AFK06119"/>
        <property type="gene ID" value="Theba_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0391"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986267_0_0_0"/>
    <dbReference type="OrthoDB" id="1593269at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="31513" checksum="6ECCA132B4D2D6CF" modified="2012-07-11" version="1">MIRFRSATITLIIINVIVYLLVAFMGLFRGPQGISYRDLITVYGGVSRFALSNGLIYTPLTALFLHGNLMHILFNMWALFQLGHVVEGVYGSKWYLLFYFVTGISGSLSAAAFSTAFTIGSSSAIFGLVGILFTLGLKKDTPVVLRSITGYSLLPIILINLFLGFSIPGISNAAHIGGLVVGAIIGWFAKPAYARSARSRRVYTRVKEKTPEEASRDILVKYIPVLNGMKDNRSEERTIRIAQLRSELSSLKDQEIGSKVLWELYKRDLLSQEEFERLRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K4</accession>
    <name>I2F2K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0429"/>
    <dbReference type="EnsemblBacteria" id="AFK06157">
        <property type="protein sequence ID" value="AFK06157"/>
        <property type="gene ID" value="Theba_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0429"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828487_0_0_0"/>
    <dbReference type="OrthoDB" id="8482at200918"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="335" mass="38208" checksum="78F860B1842AE29D" modified="2012-07-11" version="1">MVSSGGLILKGFDSEDKVYLEGDLADPLSVVGGEHSGDLLCVGDSAILVGDRDELKEYLVSRPERLEKLFVDVEKDLSLCSGKGPFDLDEFTASLVAKKQCWLEEYPPLLFGEKSLYRKGIRLIERKEYPSAQEVLRSYLDQYQNSPLSRPVKLFYAFSCFLNDFLEDALASIMDILESAEDEISRIARFFVCHMGLFESGFKFLYKGPRYSSDLFRILKADYRRIRKADSDRIVFEEGRKAGSVLFLLKGEIALLKKRGDKNSVLFTIKSPSSIGEIQVLSRSKWDTTLKIKSNSEYILIDRDKLVQYLIHKSPQDGFRMVEYLLGYIRQTSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K7</accession>
    <name>I2F2K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0433"/>
    <dbReference type="EnsemblBacteria" id="AFK06160">
        <property type="protein sequence ID" value="AFK06160"/>
        <property type="gene ID" value="Theba_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0433"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="286" mass="30974" checksum="786B3544D894E87A" modified="2012-07-11" version="1">MIGIICDSVVDLPVELAERDDVYVVPIMVVLGEKSYREGVEISKSEIADYLDYNFARTSLPSPADVTEAFETMYSKGYDELLVVNLSSGLSGTYNLFKTIGEQFVSEHHSVKVESIDSLSLSGGIAMLVHKAIRMKERGDSLRVIASDLRSRAGIKNIVYFVLPTLKYLKQSGRIGKLQGSVGEILDVKPIGTINSGGIFILSGRARGMKKAVEKMVDRLIVAVKGKRVLCLALYHSGNDSDTLALVEWAKRKIISLSETLLTGELSSAILVHGGRGIIGVGALIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K8</accession>
    <name>I2F2K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730276.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0434"/>
    <dbReference type="EnsemblBacteria" id="AFK06161">
        <property type="protein sequence ID" value="AFK06161"/>
        <property type="gene ID" value="Theba_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0434"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_0"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
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        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="37525" checksum="254E8055C9F11BFD" modified="2012-07-11" version="1">MKKPTIKDVASLSGVGTGTVSRVLNGGSVKETTRIKVMKAIDKLGYQPNQVARTLAGGKTKRILFLMPEIRTEFHWRVMKSFDEYLDKMNYEMVIYPVFSDKRLKKLRSDPSLIQNIDGAVICTMNIEFLSRKYIDFGTNVVLFESQSDEFDCVYLDNVLGGRMAAELLIECGSTDLFVISFDEENTILATENFEKRILGFTSYLKEKGYEFNEEKLVYTSFFFETAHERIASILSEYDRPGIFALADNFALEVLQMASAMKKIPGKDFFLVGYDNQSWTERAGLTTIEQPMEDMGRKTAELIIQKIENPGQYVQPVKFLPSLKRRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R8</accession>
    <name>I2F2R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0495"/>
    <dbReference type="EnsemblBacteria" id="AFK06221">
        <property type="protein sequence ID" value="AFK06221"/>
        <property type="gene ID" value="Theba_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0495"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_2_1_0"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="231"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="707" mass="78109" checksum="1FC8692A8BB16738" modified="2012-07-11" version="1">MIDPRLNQKLVDLFSYRYRWQSLREIQSKTIPPVLDGKNLLLIAGTASGKTEAVMIPVVNRLLELSAGLKCIYFAPLKSLINDVASRLELILRPFGMVVGKWHGDLTKSEKFSTAKEASILVTTPESVEGIFLSENIDLLSKIEFVIIDEVHAFIDSPRGAQLASLMERIKILSGIDQQRIAMSATVGNPELLMEWLSGSSNRESEIVTDDSKSKRTIEVLTEGEISPAEYLARLLEETDDKILLFSYSRAKAEDFAASAKALGLAIPVHHSSVSKSLRVEIEEEFKRDKKLRAIVATSTLEMGIDIGDIDRVIFLEIPPSAASFLQRAGRAGRKKNKSTISVFIEDPQSLYNLLGILDMLEEGSVELLKPSSFHLPLLGHQLIGLTKTAGSLCKEDLTVLKRAFPFRQIGSADFEIVLDHLVKESFLARRGNAITSGAATAEMIGSGKEKMDFVVLFPGGFDYSVIFNGHEIGKIHPAVLSTSSDDEVSFLLGGRSFLVKEVSPARKTVHVVLGDSGKPPSWFGSSSLMTKEFARAIKSSLAEIKIPDGVVLSQDASQTLLDFIDNHRASSISISLRNSRKSVIIETFAGDMSNIFLSLCIKAVSGIKKISSSWHSVIVKDGIDIDELHEMLLAISRMEENEIKGILSTYLRENPNELKKLYELLGEKLDRFVPQQLLVKYVIHRFFDSLLLKELSEAVMVTDADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T6</accession>
    <name>I2F2T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730346.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0516"/>
    <dbReference type="EnsemblBacteria" id="AFK06239">
        <property type="protein sequence ID" value="AFK06239"/>
        <property type="gene ID" value="Theba_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0516"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_0"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="36263" checksum="00BCEC40E9069133" modified="2012-07-11" version="1">MKKLIEKVVTVSSPSGRESAIREAIVEEIKPYVDDMKIDPLGNLIGMKKGSSGKKLLLDGHMDEIGVVVTHIDSNGFLRVDSVGGLSPYMLLGSRLIFETGASGVVDVEGETAKELGETIKNLDYDHVFVDIGAIDKKDAENKAPIGTFGTYDSTFVDLGKRIVSKSMDDRIACAIMIQVLKELDKPKDDVYFVFAVQEEVGIVGASVAAFDIMPDMAVAIDVTAGPDTPKSFKRMGFKLGGGPTIKIKDRGSVSSARVVSRLKEVAEKKEIPTQYEVLIFGGTDARGYQTTGRGIASGTVSIPCRYVHSPHEMVDYDDVLNAVRLLKGLAEEGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U3</accession>
    <name>I2F2U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730353.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0523"/>
    <dbReference type="EnsemblBacteria" id="AFK06246">
        <property type="protein sequence ID" value="AFK06246"/>
        <property type="gene ID" value="Theba_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0523"/>
    <dbReference type="eggNOG" id="COG0122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_3_0_0"/>
    <dbReference type="OrthoDB" id="1781735at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="127"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="297" mass="34483" checksum="BF4D6CFFA52323CB" modified="2012-07-11" version="1">MIEFSFRPEKPIDLDSTLDCGQTFRWVKDGEWWKGVVRDTVLFMKESLNEITVKSSSSSLLGMDISTGIIHYLGLEDDLDEIHSTLRRRLSRFNRSARDISERALSEASGLRILRQDPFEMIVEYILSTRNSIPMIRWMSDSLSAAFPENRVDFCGETFYKFPSLGQAKLISEELLTNLKIGFRVPWLMKLFSRIDQESYFSQLIPLTVEEKLEELIRHDGIGYKVGSCVVLFAYGELNAFPVDIWISRVMKDIYGIEGSTKKIMQFGMNSFFPYGGYYQEALFRYYRTHKLGRILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F370</accession>
    <name>I2F370_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">Theba_0656</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730448.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0656"/>
    <dbReference type="EnsemblBacteria" id="AFK06373">
        <property type="protein sequence ID" value="AFK06373"/>
        <property type="gene ID" value="Theba_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0656"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_0"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK06373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="28264" checksum="18321B1CF8F64190" modified="2012-07-11" version="1">MSETLSYLILGAIQGATEFLPVSSSGHLTIFSSFLKVPLDSESKAAFFAVLHLATFFAVLLFTFKDVWGILTGLSKPEKRKISFRFIVLLLVATIPAVLVGFLLEDEIKSLFSDVAFASIMLFATAAALFISDRLKGERKILDLSVAGALSIGIFQAAAIAPGLSRSGLTIFGALVIGMIRSDAVRFSFLLSLPVTFGAGILELSKVSLPISTVLLSCLLAFSTGIVGLWLLKKLVLKRRLRFFGFYCIIIGIVGLIFRGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F371</accession>
    <name>I2F371_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730449.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0657"/>
    <dbReference type="EnsemblBacteria" id="AFK06374">
        <property type="protein sequence ID" value="AFK06374"/>
        <property type="gene ID" value="Theba_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0657"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_2_6_0"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="PTHR23200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="206" mass="23029" checksum="6B7D5896DF64EA2B" modified="2012-07-11" version="1">MDLNLLFPGSLVYVPGMMDAPTSSCVLLVEDYKKILIDPGGFASMKVLEDGLTSLGLSPDDITDILLTHFHLDHAFSSVFFSKATIHLHESFSTRDYSSFGPIIGSVYSKIIDSWKSIETFSGGERILGAIDVLSSPYHSRDHVSFFLQTENHGRVFICGDVCARQIHYHEMRKGMRSDPAAAFVLKHFERADAVIFSHDLPLFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F374</accession>
    <name>I2F374_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ORF">Theba_0660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0660"/>
    <dbReference type="EnsemblBacteria" id="AFK06377">
        <property type="protein sequence ID" value="AFK06377"/>
        <property type="gene ID" value="Theba_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0660"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_4_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="99" mass="11678" checksum="D11C32662B1EB760" modified="2012-07-11" version="1">METKVSDELLKHLEGLAKLELLEDERIELKKDIEEILQYMTLLDGVDPDAEEMVTPVEKSLEPREDELVEFKESRLIRDLFPETEGSYLKVPRIYKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C6</accession>
    <name>I2F3C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">Theba_0712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730487.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0712"/>
    <dbReference type="EnsemblBacteria" id="AFK06429">
        <property type="protein sequence ID" value="AFK06429"/>
        <property type="gene ID" value="Theba_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0712"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084630_2_1_0"/>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="16725" checksum="6B85D92455AB1ECA" modified="2012-07-11" version="1">MRIRVGIGYDIHSIKPGDRGMYLGGVKVSDTFYLVGHSDGDALCHAIVDAILGSTSSGNIGISFPEDEKNRDRRSIEFLMEVAESIRGRWRILNVDAVVVIEKVRLAGFVSSITENVARALGIESEQVNVKPKSGNGSSPGFVQVHAVCLLEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D1</accession>
    <name>I2F3D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730492.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0717"/>
    <dbReference type="EnsemblBacteria" id="AFK06434">
        <property type="protein sequence ID" value="AFK06434"/>
        <property type="gene ID" value="Theba_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0717"/>
    <dbReference type="eggNOG" id="ENOG5034514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376757_0_0_0"/>
    <dbReference type="OrthoDB" id="2166076at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="22229" checksum="064911553EA76D1F" modified="2012-07-11" version="1">MNEKNGFNFEEMKAPAGAEPFEGSDSFFIHRDYANKLNRRLSFLDKKGINSKLAFWSLIALTVLGFLFLVILYSYSTFENTSLLIDEVNGLESAYLEVQLLSRVRNEALGSMSTRSYLNDLEEKIPIGSKPGDYNGIIASGNSRDILDLVEMIVNEPRILVKKLELRSNLGFPILPESNIPSNLSLELKIDLNVTGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E0</accession>
    <name>I2F3E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730501.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0726"/>
    <dbReference type="EnsemblBacteria" id="AFK06443">
        <property type="protein sequence ID" value="AFK06443"/>
        <property type="gene ID" value="Theba_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0726"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_0"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="3"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="374" mass="41506" checksum="A54ADA1285F5E44C" modified="2012-07-11" version="1">MRYFDNNATTKMESDLAERFAKLCVEEYANPNSMHSFGLREARYLEEARRKIARSLSSDPREIYFTSCATESINWILRSSVLFKGRRKRIVTTSIEHKAVLNTLKDLKASSDIDYRTVGPERNGIVKVAKLLDEVDEETFLVSLMAVNNVTGAIQPYEEIGEELRRRNVLFHLDAVQTIGKIPIDFVSCFCDYASFSAHKFHGPKGVGVTYVRQGTPIRPLITGGGQERGMRSGTQNVPGAVIAATALQRAVECTQESSSRLREYQHRIKETVEELDGVVNTPENSISNTVNASFAGIRSEVLVNALSEEGVFVGTSSACSSRGDGGQYVLDSMGLDFSLASSSIRISMSRFTTEEDVAFLIEKLKKTVPLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F0</accession>
    <name>I2F3F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="7" type="ORF">Theba_0738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492414.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0738"/>
    <dbReference type="EnsemblBacteria" id="AFK06453">
        <property type="protein sequence ID" value="AFK06453"/>
        <property type="gene ID" value="Theba_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0738"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_2_0"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="180" mass="20259" checksum="DAAD1270D14FE4DA" modified="2012-07-11" version="1">MLTRERKEEIVESLTKAYKDSSLILFADYKGMKVENITTFRDKLYENYKERAQFTIKKNTLVRLALNKAGFEESEWKDSISGTTAVLTVEDVDPIAALKIITDFNKNNKTLPLIKAGYLEGRFFTGDRASDLAKLPSREQLIAMVVGGFAAPITGFVYTLNGVLTKFLYALNAIKDKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F1</accession>
    <name>I2F3F1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">Theba_0739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492415.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0739"/>
    <dbReference type="EnsemblBacteria" id="AFK06454">
        <property type="protein sequence ID" value="AFK06454"/>
        <property type="gene ID" value="Theba_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0739"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_0"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="59"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="128" mass="13504" checksum="1B6394AF991ADEFE" modified="2012-07-11" version="1">MTKEELISAIKEMTVAELSDLVKALEEEFGVSAAAPVAVAAAPANGGAAAEEEEEQTEFKVVLKSFGAKKIDVIKVVRSITGLGLKEAKDLVEKAGTPEGVVKENLPKAEAEELKKQLEEAGAEVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L1</accession>
    <name>I2F3L1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="7" type="ORF">Theba_0800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0800"/>
    <dbReference type="EnsemblBacteria" id="AFK06514">
        <property type="protein sequence ID" value="AFK06514"/>
        <property type="gene ID" value="Theba_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0800"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="142" mass="16867" checksum="A09E18CA20ABE24A" modified="2012-07-11" version="1">MNLRDQSLSKNERLRRKADFDRVFKKGKSIVDPFFVVLYVKNGLPFSRIGISIRRKFGKAHLRNRLRRLVKEVYRTNKQVFPEGYDILFIARKDLSDLFKKRKVGYFDIVQIIKRIAEKIGETSDEKDTTVSDRFLQKKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N0</accession>
    <name>I2F3N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730579.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0819"/>
    <dbReference type="EnsemblBacteria" id="AFK06533">
        <property type="protein sequence ID" value="AFK06533"/>
        <property type="gene ID" value="Theba_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0819"/>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093128_0_0_0"/>
    <dbReference type="OrthoDB" id="1696461at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007536">
        <property type="entry name" value="16SrRNA_methylTrfase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112">
        <property type="entry name" value="PTHR36112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04445">
        <property type="entry name" value="SAM_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="260" mass="30135" checksum="ADB7ED36D4F71AFB" modified="2012-07-11" version="1">MRFVVTTSHKPTREEVVNARTLAEELGVKYVSRGRLREFEKESPVDFYYVFDKNGQLSIKAGQSVFFFHPGMSKVRYKNIKLQNSDYLINSMELSGEEVVLDTTFGLGNEALLIAHFLPRGKVVGLEASEHIFRVVAHGLRNYPYTDEWIREASTRIELHNINLREFVKSCADNSYDIVYCDPMFDRPQLSSHSINPLRPFAVYERIIRSDVDEMIRVASKRFIIKSRTRDTLFEELGLHFDRLWGSKKSGVLYGVIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q7</accession>
    <name>I2F3Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">Theba_0846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730601.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0846"/>
    <dbReference type="EnsemblBacteria" id="AFK06560">
        <property type="protein sequence ID" value="AFK06560"/>
        <property type="gene ID" value="Theba_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0846"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="466" mass="50631" checksum="84EC5F55280B45ED" modified="2012-07-11" version="1">MTKNPLNLRLSEIISLGDTYKFYRERIDKYNNELNAFLQVRTFSEERQGFPYAIKDNILAVGTRTTCASRILENYDSPYDATVTQKLNSKGGQLLGKTNMDEFAMGSSTENSAFGPSRNPWDLNRIPGGSSGGSAAAVAAGLAPFALGSDTGGSVRQPASMCGIVGFKPTYGLVSRYGLVAFASSLDQIGPMTRCSQDAADVMSMISGHDSRDSNTIRHALSFDTSLGGNLKGLKFAVPSEMLSYPGLDEEVKEKFLSITRDIERSGADVEVISVPSVEYAVATYYLIAPAEASSNLSRYDGIRFGPRQQSEDYEGLTSKSRDRGFGKEVKRRILLGTFTLSATYYDAYYRKALKTRRVMAGELSKVLDEYDFILNPSSPVVAPRIGEINDPLAYYLMDIYTIPANVAGLPSISVPAGFVNGMPVGVLITGKRFSDVSILDAAKGIEDLSPSFSNGLAIIAERWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S8</accession>
    <name>I2F3S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0871"/>
    <dbReference type="EnsemblBacteria" id="AFK06581">
        <property type="protein sequence ID" value="AFK06581"/>
        <property type="gene ID" value="Theba_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0871"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825860_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="357" mass="38901" checksum="C42E86E5101B9C40" modified="2012-07-11" version="1">MKRFMITSESELPIEPSDPAFVVLDVTDPRKISFVDRIRTLGTTVSFASHNGLLFCSEIGHLEIFDVSSLPKISRVSMFEGNHPGNTTQYEVSEKRLYLSSYQHGISVIDVKNPTSPVLLGSCDCDISVEPGAGIGPYGISQIVKRGHYVFGVAMDYVATKEREALYVYDVSDFENIRKAARLSTTPVKGHGMAIAGSHLFAVGACGILSIDISSPEEPLTIGELPLEGRFGVFARDYRNRLLISGRILEFAEEESSAKADSKLSSKPLLSSDRSQNGFFQVIDVSNPIHPRLLSETRIDTGEGFGLLVDKDIAYLACSNGVATVDVKDVNNPAVLALFDELDQTKEYIGAAIVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T6</accession>
    <name>I2F3T6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="9">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="9">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyS</name>
        <name evidence="11" type="ORF">Theba_0879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730627.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0879"/>
    <dbReference type="EnsemblBacteria" id="AFK06589">
        <property type="protein sequence ID" value="AFK06589"/>
        <property type="gene ID" value="Theba_0879"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0879"/>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007220_2_2_0"/>
    <dbReference type="OrthoDB" id="213210at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="567"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="678" mass="77897" checksum="C32D39E6D60C5239" modified="2012-07-11" version="1">MSDHKALLEVGIEELPSSEVQGIKTQLKERIERSLDNNRLGYGELEVFVASRRFGVLIHGIELKQSDFVEKKKGPSEKIAYKEGEPTRALLGFLRGSNAQLEDVSVEGGYVYVQREIIGKMAEELLPQIFSESLRSLEFKKPMRWGDGTYRFARPVKWITAMLDTEILDMELFGKRSSNKSRGHRFFFDEVEVSPENYFQNMRDALVIARESDREERTLSEIRRIESDIHSQIPVDQELLAEVVSLTEYPTAVLGNFMEKYLSLPPEVIIVTIKHHQRTFPVYKEGKLTNNFVAFQDGPADPLGNIRLGYEEVINARLEDAFFYFEKDKERPFEQYVDGLQGILFQRGLGTLRDKTERTTALSSEISRRLKAKSDELFEVERTALLAKADQITRVVQEFPELQGIMGRIYAEASGEKSGVALGIEEHYRDILVPTTLTGAVVGVSDRIDTLAGNFAIGNIPSASKDPYALRRKASFIFRTMHHLGWKLDLLELLERALNNLNKTSEETLDSLKDFFSSRYEAFLLERGFSMNIARSVKMWWRFPYLGVRAAEAISEYVKNEDFNDLLIAYQRVHNISRGHSGNSFDGSKFIEQAERDLLNNYLKCFDDVMEALERDDFEKSLQLLTSLKPHIDRYFDDVFVMAEQEDIRLNRLGFLKSVDQLFLKIGDLSLLLEEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V8</accession>
    <name>I2F3V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-threonine 3-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0901"/>
    <dbReference type="EnsemblBacteria" id="AFK06611">
        <property type="protein sequence ID" value="AFK06611"/>
        <property type="gene ID" value="Theba_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0901"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="8">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="37967" checksum="E2C1E9724814DB0D" modified="2012-07-11" version="1">MESETMIAIVKERPAPGLTLKRVPVPRELGPHDVLVKVKRASICGTDVHIYNWDAWSQERIRPPQIDGHEFTGEVVSIGGDVSSVKVGDSVVSETHIPCQKCLQCRTGKMHICKNMQILGVHRDGVFAEYVRVPEVVLWKVDPSIPLEYASIMEPFGNAIHTALVTDLTGKNVLITGAGPIGVMAVAVAKVSGAAQVIVSEIKEFRKELARKMGADVIIDPTKEDLTKKVKAMTEDNGADVLLEMSGNTTAFKQGLDSLTNGAVVSLLGVFPGELSFDINGLFTFKGLTMYGITGRKMFETWQVATQLLKNKRIDLSPVVTHVLPAEKFEEGFDVMIRGVSGKVILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y3</accession>
    <name>I2F3Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730659.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0930"/>
    <dbReference type="EnsemblBacteria" id="AFK06636">
        <property type="protein sequence ID" value="AFK06636"/>
        <property type="gene ID" value="Theba_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0930"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_1_0"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="770" mass="83997" checksum="111DE3B0337C3D10" modified="2012-07-11" version="1">MTDSFVTVGKPKRKVDGLAIVRGKPVYTPDYDMPDALVVKLLRSPHAHALVKNIETEQAKLINDVVDIFTFSDVERIPYTRAGQGYPEPSPYDTFLLDRKVRYVGDPVAIVAAKTEKAAKDALRNIKVEYEILDAVLEMKEATKEGAPIIHDESECAGVYDKSRNIAAHYEMDLGDVEETLKTCDVVIERTYHIDTQLHAALEPHNALTYLDSVGRLIVITSTQVPFHCRRILSHILNKPIADIRVIKPRIGGGFGGKQSVIVEPYAAFVTLRTGKPARITYTREEVSMATNIRHEMSFDVTVGAMKDGKIKAISLNGMSNTGAYGEHSLTTFMVSGSKTLPLYNKVEAVHFGGDIVYTNLPPAGAYRGYGAPQGLFPLDCAIDELAYEIKMDPLKLKEVNSIREGETSPIFEIMGEGREGVPQTIKSCKLQECIDLGKNEIGWESKRGKKIRNGSKVRGVGCALAMQGSGIPKVDMGAATIKMNEDGSFNLLVGATDLGTGSDTILAQIAAEVLTVPLERVIVYSSDTDITPFDVGAYASSTTYVSGNAVRLAAEKVKDRLFELAGKYLERSVSELSLQSGIITCKDGPSVSLSELCTVHMYTFNQQQISESASFVGEESPPPFAASFAEVEVDTDTGKITLLNFVSYADCGVALNPIQAIGQLEGASMQGIGWALFEDIIYGKNGRMLTNDFFTYKVPSRMDYGKLTCRLVDSYEPTGPFGAKSIGEIGIDTPIPAIANAIFDATGIRLRHAPFKSERVLFEILNMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F413</accession>
    <name>I2F413_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative MccF-like protein (Microcin C7 resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730687.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0960"/>
    <dbReference type="EnsemblBacteria" id="AFK06666">
        <property type="protein sequence ID" value="AFK06666"/>
        <property type="gene ID" value="Theba_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0960"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_3_1_0"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="183"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="35056" checksum="8C7BE95FCB8FEC6F" modified="2012-07-11" version="1" precursor="true">MRRVWLILMLCVGMFLTSSVLISKEIRTIFVTAPASFPERSKLEAGVSALRNVGYRVIVGRSCEVSLSSREKANELNDAFANPEYDAIIAARGGYGSYNLLDWLDWEVIASNPKPLVGYSDITALLLSIYFKTGQTTFHGPMVAVELGSDTRSVQNIAAIFNGERTIRFNYQSIPVIEGKMIGRLIPANLSLFQALQGTEYLGSLKDAILVLEDVSETKESLERMIWNIAHLDDFSSLRGVVFAGFTEIKNGDLDDIKRMIHDYFLDKEIPVWIGLPSYHGDFPKVVLPVGRWVEIDMEKGTIEIVSVPEAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F451</accession>
    <name>I2F451_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0998"/>
    <dbReference type="EnsemblBacteria" id="AFK06704">
        <property type="protein sequence ID" value="AFK06704"/>
        <property type="gene ID" value="Theba_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0998"/>
    <dbReference type="HOGENOM" id="CLU_111486_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045407">
        <property type="entry name" value="DUF6512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20122">
        <property type="entry name" value="DUF6512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="176" mass="19155" checksum="D0603AF49DD5EE0F" modified="2012-07-11" version="1" precursor="true">MRKTSFPSCEVVGFSFVFIVGTLLHMAYDWSGDDAIVGIFAPVNESIRELLKMVFTPGLILLFLELLFCSEIPTASFLSGKAVGIYVMCVTILGGLYSYSLVIHYGLILDVLLMVIAIALGQLVSFKISPRIAADSTAGIISLVMLVLLGASFVVFTFLPPHWEFFRDSITGAFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F499</accession>
    <name>I2F499_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpC</name>
        <name evidence="10" type="ORF">Theba_1047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1047"/>
    <dbReference type="EnsemblBacteria" id="AFK06752">
        <property type="protein sequence ID" value="AFK06752"/>
        <property type="gene ID" value="Theba_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1047"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_1_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="8">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="132" mass="14997" checksum="7F961751C464FBFD" modified="2012-07-11" version="1">MALKIRIITPYGIEWEGDADFISFRSTEGEIGYLPERAPALMELTVDVMKVRSGSNTLQFAVHGGYVLQEREGLTIVTDAAETPEEISVERAKQRLKRAEELLQVSKSRRERARNEAKLQRHMLRIKIGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A4</accession>
    <name>I2F4A4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="14" type="ORF">Theba_1052</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492794.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1052"/>
    <dbReference type="EnsemblBacteria" id="AFK06757">
        <property type="protein sequence ID" value="AFK06757"/>
        <property type="gene ID" value="Theba_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1052"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_4_5_0"/>
    <dbReference type="OrthoDB" id="2229351at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK06757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="161" mass="18570" checksum="F31C7581B9B472AD" modified="2012-07-11" version="1">MIELNLTAILSILNFLLLFFVLKKLLFDKFFDIMKQRKEKISGEIAEAEKLRTEANDLKREYEAKIQEARSSSNEIISQAERQAEEIVRQAREGAQQEIQRMYKAAELQIQREREEAAGEIKGAIVTAAVAMVGKFLQKDMDEAARKQYARRILESMGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A7</accession>
    <name>I2F4A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492800.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1055"/>
    <dbReference type="EnsemblBacteria" id="AFK06760">
        <property type="protein sequence ID" value="AFK06760"/>
        <property type="gene ID" value="Theba_1055"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1055"/>
    <dbReference type="HOGENOM" id="CLU_2093955_0_0_0"/>
    <dbReference type="OrthoDB" id="1916175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="12564" checksum="147C95ACD85E2A0E" modified="2012-07-11" version="1" precursor="true">MIETRTMMIKTATILAALAIVESGILAFIPLPGSELGVFYGTAFSLLALLLINYDAHIMITEKKRAPTGFLVRYAFYGICFATASTVSPGFFLGSFLGIMNLKIAAIAFGRWLCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A9</accession>
    <name>I2F4A9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="16" type="ORF">Theba_1057</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730762.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1057"/>
    <dbReference type="EnsemblBacteria" id="AFK06762">
        <property type="protein sequence ID" value="AFK06762"/>
        <property type="gene ID" value="Theba_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1057"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_0"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="14">
        <location>
            <begin position="3"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="13">
        <location>
            <begin position="303"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="15">
        <location>
            <begin position="656"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK06762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="896" mass="101802" checksum="E7FDE94390A2B660" modified="2012-07-11" version="1">MPGKLYLFDGTAIFYRGYYGIDVTLTNSKGEPTNALFGTARMLSKFTRERMKNGDYAIFAFDRKELTKRHVAYESYKATREAMPDALVAQLKDVPELVEAFGIKFLSIAGIEADDIVATAAKKYRDKVDEVLVITGDKDLLQLVDDKVHILRFVTGLTDLDLYDREKVLSRYELEPERLHALLSLAGDSSDNIPGVPGIGIKTAQKLLKEYGDIEGIYANIRKLSPGLRKKLIDGRSSLELSMELVKLLDNEDLNIELDDIKYEGFRKNDLRKIFLKLEFSSMMNEFNLTDKADDSFAEIDGYRLVKSENELERLFEKLVSNPIFAIDLETSSLDPHCAKIVGVSISIDEGSGYYIPIAHESDGWQADRDYVLKNLKKLLEDRSTKIIGQNLKFDYSVLAVNGIHPVVPDFDTMLAAYLLSPDAKRFNLDELAMKFLGYKTIKFEDLMKKNQLGDDFTKVPLEEAARYSVEDADISLRLSSVLRKKIYEQELEEIFRKVELALIPVLADLELNGVYFDVPSLKNLSEKYGKILDKILEELFDLTGEQFNPNSPSQVGKVLFERLGLTPSKKTKGGSYSTSADALEEIADEHPAVQKLLDYRKYQKLKSTYLDSLPELVNKVTGRIHTSYHQTGTGTGRLSSSNPNMQNLPIRDEEGKEIRKCVIPQKKGWKIVSADYSQIELRILAHLSQDKQLLDAFKNDKDVHSLTASNLYGIKESEVSEEQRRIGKMINFSIIYGISSYGLASRLRIPTNVAEEMISNYFKAFPEVRAFIRDTISEAKEKCFVRTMFGRKREIPQFKTKNRNVIQEGERIAINTPIQGTAADIMKMAMIKIYNLLKEKEMESFAILQVHDEMVYEAPEKEIEKLKEILKEGMSEVVELSVPLDIEISVGDYWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C3</accession>
    <name>I2F4C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">16S RNA G1207 methylase RsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730774.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1071"/>
    <dbReference type="EnsemblBacteria" id="AFK06776">
        <property type="protein sequence ID" value="AFK06776"/>
        <property type="gene ID" value="Theba_1071"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1071"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_7_2_0"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="202" mass="22569" checksum="BB81FB6C4B466E84" modified="2012-07-11" version="1">MKEDFQHYYTDQTEPPKSIRSVYLRLRNGHSYTFKSPEGVFAFGKADRASLLLIENCILEGQESILDLGCGYGAVGITLKLEHPDLKLHMSDVNTRALTFSKINARDHNILADIRKGDLFSPWEKTSFDSILSNPPIAAGKAVWQRMITEAPEFLNEGGSLQIVAYHNKGGSRLEAIMRETFGNVITATKSGGVRVYVSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C5</accession>
    <name>I2F4C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalt transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730776.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1073"/>
    <dbReference type="EnsemblBacteria" id="AFK06778">
        <property type="protein sequence ID" value="AFK06778"/>
        <property type="gene ID" value="Theba_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1073"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="29198" checksum="BAFA1DA89EE920B5" modified="2012-07-11" version="1">MLTVKEVSFAYKGHGNGSQVSALKRVTFDIADGSFVILTGRTGSGKSTLLQLLCGLIEPDGGEIHCGDGDLSSKSAMIFQYPEDCFFNPTVIEELEFGLKTAGKKGSERLNGITEVIGFDLQKFGSRTPFSLSGGEQRLLAIASMAVLDKAILLLDEPTSGLDDTAVQRVRKLLLSESRLGKTIVVSTHWPAEFMDMATHVMNLEDGSLEYFVTVEEYVESNLHNKQLEEKEKYLLDYYKRFKTFPDNDEELIEFARREKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4E8</accession>
    <name>I2F4E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492836.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1096"/>
    <dbReference type="EnsemblBacteria" id="AFK06801">
        <property type="protein sequence ID" value="AFK06801"/>
        <property type="gene ID" value="Theba_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1096"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_2_0"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="373" mass="41340" checksum="324B6CDD4AFAEC39" modified="2012-07-11" version="1">MKAMILAAGAGTRLRPLTNRLPKPMLPIIEKPVIEFILELLSKYDVKEIMINVSHLAGVLQNYVRSGYRFGVRVGYSFEGHFEKGQLVPEPVGSAGGLKKIQEESGFFDETFVVLCGDAIVDFDLAEAFEFHKASRSVATIVSKEVQMDKVSNYGIIVSDSSGRVESFQEKPPAEKAKSNLANTGIYIFEPEVLEYIPKNQFFDIGGELLPLLVQKKERVFSLDTKIDWYDIGRNSDYLEILAKALEGEIKGFKPSGKEVTKGLWRGTGSLLEKTTKIITPVYIGPGSVIEKNVKLEGPVMIGANCRIHEDVELSNVFLGDYIRIKPGFKAKNLLITPEYYVGSDGKGGMIADSNLKRYVSDVRTMEANPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F5</accession>
    <name>I2F4F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">Theba_1103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730805.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1103"/>
    <dbReference type="EnsemblBacteria" id="AFK06808">
        <property type="protein sequence ID" value="AFK06808"/>
        <property type="gene ID" value="Theba_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1103"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_0"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="32008" checksum="519F87959F802266" modified="2012-07-11" version="1">MFRGTGTAVITPFKDGAVDFGSFRRFLRFQLENGIEALIVLGTTGESPTINESERTKLIRIAVDEAGGKVPVIVGTGTNSTEKTIKSSLKAFDEGADGVLVVVPYYNKPTQEGLYRHFGEIATRVQGPVIIYNVPGRTGANILPDTVIRCLEFNNIVGVKEASGDQYQVDYLISALRSKESDFKVWSGNDDQAFHLCCSGGDGVISVISNVAPMKTSTMIHSILKGDLHIARGLHLELLPLMKALFVESNPIPVKYALSLMNYCQNELRLPLYELSEGNRNVVRKALQESGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I7</accession>
    <name>I2F4I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06840">
        <property type="protein sequence ID" value="AFK06840"/>
        <property type="gene ID" value="Theba_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1136"/>
    <dbReference type="HOGENOM" id="CLU_1738345_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="17111" checksum="B57432BA19BA33B0" modified="2012-07-11" version="1">MHLFHLTLTNLEQILPLEERASFSSLTSALFGERWTADGQRRLHSDQRVFSRVGIDGDRRQEPVSTLFEMLRDDNVRRLCGSFVGANGCSPEKALVEMSAFYAKNVADRRSIWEPVRLRLARIAMRTAFSRPDPVQTHHGMTAEGGFRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K8</accession>
    <name>I2F4K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1163"/>
    <dbReference type="EnsemblBacteria" id="AFK06861">
        <property type="protein sequence ID" value="AFK06861"/>
        <property type="gene ID" value="Theba_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1163"/>
    <dbReference type="eggNOG" id="ENOG5033EYG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975943_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="32987" checksum="641132F7AA3252B0" modified="2012-07-11" version="1">MMHPKSFRKLIVDNAVGMLWSQWVNLGAWSRAEQRVNSFSDPESAIAFSSYFCKYEKRLDKISLDWSKVNLQYINHSRLKRLRKTVTDHIELPDDFYEVQAATTSSKYITEPNAKDMANLLVRLRLLFGSTTRADVIFHLLTKGSANSNQIATYRFLNQKAVLLELEKLAKAGVLVERRSSRERLFSAQRQFAKFFEFEIQPISSPWFLLASLLMLEGCLTDELIDDEYLVFSTFMDNKRKLSDYLQKAGECNLTLEGSTADEFYENVTEYYTCLCPVCESIHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M6</accession>
    <name>I2F4M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730868.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1181"/>
    <dbReference type="EnsemblBacteria" id="AFK06879">
        <property type="protein sequence ID" value="AFK06879"/>
        <property type="gene ID" value="Theba_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1181"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_0"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="327"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="434" mass="48105" checksum="4753AA6C057481E5" modified="2012-07-11" version="1" precursor="true">MLKERILDKSAIVGVIGLGYVGLPLAVEKAKAGFKVIGFDIQESKVKMVNEGHNYIGDVVNADLEKIVSEARLRATADFDELAGCDVIAICVPTPLDVFKQPDLTYVINSTENVAKRLHKDMLVVLESTTYPGTTEDVMKPILEETGLVCGKDFYLAFSPERVDPGNLRYKTKNTPKVVGGVGPESTEVAKLLYESVLDAEVFVVSSPKEAEMTKILENTFRIVNIALINEMAVVADKMGINIWDVINAASTKPFGFMPFFPGPGVGGHCIPIDPFYLTYIARKYDYHTRLIELSGEINDSMPEYVVTRVMKALNERGKCMNGAKIVMLGIAYKEEIEDMRESPALKVLEHLEENLAHVSVVDPYVPEFTWEGKTVKTVNLTEELIKESDAVIITTAHKKLINYSMIVKNAKYIFDAKNVLSKMDIAGENIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X5</accession>
    <name>I2F4X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730954.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1290"/>
    <dbReference type="EnsemblBacteria" id="AFK06978">
        <property type="protein sequence ID" value="AFK06978"/>
        <property type="gene ID" value="Theba_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1290"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="253" mass="26987" checksum="FDF30927A30EF437" modified="2012-07-11" version="1" precursor="true">MKRFEGKIVMISGGSSGIGAETAIAFAEEGAKVVITDVNEEKGRKLAEEINESGGTAVFMKHNVADAKQTKEIINKIVEKFGKLDVAFNNAGIAGPSLPISEYPEEDWERVISINLLGVYYGMKYQIQQMLKQGGGAIVNNSSILGKVGFNNASAYVAAKHAVVGLTKAAALEHASKNIRINAVNPAFIKTPLIENAGMKEGTEMYDMLVGLHPIGRLGNPREVANAVLFLSSEDASFVHGESLMVDGGYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z2</accession>
    <name>I2F4Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate/sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730967.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1307"/>
    <dbReference type="EnsemblBacteria" id="AFK06995">
        <property type="protein sequence ID" value="AFK06995"/>
        <property type="gene ID" value="Theba_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1307"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_0_0_0"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="313" mass="32094" checksum="9AFFF90204E498C7" modified="2012-07-11" version="1" precursor="true">MILALLPAVFFGWTLGRNDAANIYGTTVTSGILRYRSAALISALAVLIGAIIGGAGGMQTLSKLSSHTLLSASVNAAAAGISVLLLNRIGLPVSSSQAVVGSVVGIGLISGGVDWLAVLKIVACWITTPLGAAIAGYISYRFFGFWFRKIPSILAQDIILKSSAIIIGGLGSFALGANNVANVTGSFAEIIGVDKAVLIGGLSISAGAIMFSRRVMYTIGTKIVALEAFASIIASLAQSVTVLIYAFIGVPVSVSQAIVGAVIGVGLARGTKNFDSGMTRRIVYGWVFTPVISGVISIVLYLSLSSILVTLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F529</accession>
    <name>I2F529_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnfD</name>
        <name evidence="11" type="ORF">Theba_1344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486763.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
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            <end position="301"/>
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    </feature>
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        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="33948" checksum="4FDC4B4E5C299337" modified="2012-07-11" version="1" precursor="true">MKLSMMAAPHLRSEDSVRKIMLDVLIALAPAAVWAVVSFGLKALVLIVVCTAGAEVLDFFVMRFIRRKKNFKPDLSGSVTGLLLALNLSVAVEWWQALIGVFVAIVIAKAVFGGLGKNFFNPALVGRVFLLISFPVQMTTWLSPFDMQTTATPMAILKQGGPRVFSLQEMFLGTIPGSLGEVSALLLLLGFGWLLFRKRVSPFIPVAYIGTVVIMAAIFNGVNPGFGSPLYHVFGGGLMLGALFMATDMVTSPMSIKGHVIFGVGCGAVTMIIRLFGGYPEGVSFAILVMNAFVPLIDMGTKPRIFGKPKKVKSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F539</accession>
    <name>I2F539_9BACT</name>
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        <submittedName>
            <fullName evidence="3">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
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    </gene>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
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        <location>
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            <end position="82"/>
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        <location>
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            <end position="112"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK07042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="32057" checksum="6E71835A111C250C" modified="2012-07-11" version="1" precursor="true">MKLKSKAYVNLLLVVIFWGLTFPVQKNILEGLSPVFYNALRFSIALLILIPLRKKLGLKITNKSLTQGLILGLFLSGGYVFQTWGLVYTTASKSAFITSLYVGLVAIIGPVVDRRIPSRYQILALGVSLIGLYFLTTPETGFNFGDLLTALCAVSFALHVVLISYFTQKEDVDEMELLVPQFVVVLLVNMALIPFVKGSVFINGSILFVALFSAVFATIFAVAVQLKYQRFLGSVGASLIYVGEPAFALFFAMIILREIPGKMEVVGLLLMTAGMVLGGISSFVMRDRSVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F578</accession>
    <name>I2F578_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="23613" checksum="A4951D1F2D55D129" modified="2012-07-11" version="1">MSGLSFDDLYQKASEVLEIYDDACRTIRDIQIETGLRCLPSCRECCKTSGDSIQVTITEFLPLSLRLWNEGRADDLLRRLEDVPDSDRCILFEGSGEIRNEGGCTEYAFRPLICRLFGFSGVIDRLGRVAPVICKYVKTGYPLSVERFTEKFSSGLEIPVFSDYLKRVQGIDPHMGSRTYSINSALRKALEYVGMRFYYSSKGFDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D6</accession>
    <name>I2F5D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">K+ transport system, NAD-binding component</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">Theba_1453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07139.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07139">
        <property type="protein sequence ID" value="AFK07139"/>
        <property type="gene ID" value="Theba_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1453"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_2_0"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="219" mass="24199" checksum="72EF23F3186A5D23" modified="2012-07-11" version="1">MKIVLIGGEKIAYHLARRFLTKGHNVMLVNKNERFCDEMAKKLRAIIVRGDGSKRYVLEQLELDPTDLFVALTPYDQDNLVACLTASRVYGIERPVAMVNDPDNKAVFEKMGIKSVVSPTEILGVALEDSLFREHITNLLPSSEKVSILRIEMTDKSPILGEAIKDIPLPDESVIGAIVREDEVVIPRGNTVIETGDVLLVLSSPTVQSSVFETLLGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H2</accession>
    <name>I2F5H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487044.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1493"/>
    <dbReference type="EnsemblBacteria" id="AFK07175">
        <property type="protein sequence ID" value="AFK07175"/>
        <property type="gene ID" value="Theba_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1493"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_1_0"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="332" mass="36462" checksum="08A8A496EE2ED02A" modified="2012-07-11" version="1">MNLDRLTEVVFVPGMTGREEMIRAKIIEMLPEGVEPFVDDLGNVVLEVGNGDSTIAFAAHMDEIGLLVTGVNSDGSLSFKKVGGIADELLVGRHLDVITSSGESIDGVIGMTPPHLREKTDLSWQNQVIDVGTSSKEETASLGIEVLDYAVFRKQISILNDKYVAVRSLDDRSGCLALLDLLDMLMETDLDRRIVFAWTVQEEIGLIGARALSERLKPNLFFPVDSFACCSRLTGDVKPGNGPVLRMSDTSSLGDYGLGKRLMEFSRERDIPLQMGVTGGGTDGIPFQQKGKKMVPLAMAVKYLHSETEYISMEDYDNLVRLMFLISTEFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I8</accession>
    <name>I2F5I8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487083.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1509"/>
    <dbReference type="EnsemblBacteria" id="AFK07191">
        <property type="protein sequence ID" value="AFK07191"/>
        <property type="gene ID" value="Theba_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1509"/>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_1_0"/>
    <dbReference type="OrthoDB" id="1628990at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="215" mass="24090" checksum="3E80BE3C55A562CF" modified="2012-07-11" version="1" precursor="true">MKTKALLFVGGQYISTMEFYFRKLNETSFVSAADSGAEMLKSLGRHPDLLVGDMDSVSQETLQWCRGRGSLVLIYPPEKDDTDTQIALQALEERGFSNVEIFGATGLRLDHFMGTLASIYGLRHTLKATIIEENVEIGMVSREMTLFVNRGEIWSLFPYGGQQTIVSLEGFKFPLTDASLDYGKPLGVSNETVDEEIQISCKGGTALYFRWLKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K5</accession>
    <name>I2F5K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731125.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1532"/>
    <dbReference type="EnsemblBacteria" id="AFK07208">
        <property type="protein sequence ID" value="AFK07208"/>
        <property type="gene ID" value="Theba_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1532"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_0_0"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="309" mass="33733" checksum="4387F215A6722CA8" modified="2012-07-11" version="1" precursor="true">MAEKERDRLLAYFAGIGSSVIFGLSFLFTKNALEYTNPMYFLSYRFSVAFVTISLLRALGVIKVRPYKSIFKDLLLLSLVQPVMYFIFENVGVSLSTSSEAGILLSTIPIFVLIFARVFLKERLAAPQVFSVLTALLGIVLITAGKGLSTGGSVLGPIILLGSTVSAAFYNILSRKASVRFKAWEITYHMMTMGFISFTLIAVVTSLIKGEFSFYILGLGTPQVAIAALYLGTLSSVGAFFLINFMLSKLEASRSTVFVYLSTVVSLLAGVVFRGERFGPLQVIGISLILLGVWGANALARRKTREESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R5</accession>
    <name>I2F5R5_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07268">
        <property type="protein sequence ID" value="AFK07268"/>
        <property type="gene ID" value="Theba_1604"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1604"/>
    <dbReference type="HOGENOM" id="CLU_2666862_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="75" mass="8374" checksum="0E4FAD5E0FC1926C" modified="2012-07-11" version="1" precursor="true">MTTFDAFSSGLQLATWNIQLVTALSKDGSVISGRSTEDFSQRRSEFSGSLTLSLQRLFDARSRADPSRDDSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T4</accession>
    <name>I2F5T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731186.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1623"/>
    <dbReference type="EnsemblBacteria" id="AFK07287">
        <property type="protein sequence ID" value="AFK07287"/>
        <property type="gene ID" value="Theba_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1623"/>
    <dbReference type="eggNOG" id="ENOG502ZA73">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632840_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="433" mass="49528" checksum="F7822EE79A0FCF2C" modified="2012-07-11" version="1">MRVHIRSFWQMAGAVAIKRYTADCTITGNLFETQTPKKTIFENALKDMLNKNGKPWAPNLRPFLKQYTVLDKVSKILEENKIGSKVCSLCGSRVSTLEKLSMLGDPLSVKAENFQSFFSFGSGSGEVCLNCQFLGMMAGLALFYTSYKDGQDYVITYLFPESDTLESTYNTFLWMKDLHEPGSWRNLKVKARFYPQEPYETLLLSLHTLFEKTRFIPRSSFKVMQVSNTGRNNSFLNFDSFERVEELTTFFENVETLGGDFSKFMDSLVIPGSPSADVSRREEISRMILSFKPLEERLQMIIFDFDYPVHSIYEVIVASNTMKGVNGLDQMTIDLSKKAGEVIGNAVFEAQSFGDLYSLRNSRSLEDLLLTLADLEFKYAKEDWKIRIPEEFIRILNEESWKKPKALLVIFAVNKYLSRHYASSQNGGEKIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5U2</accession>
    <name>I2F5U2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR-associated endoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731194.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1631"/>
    <dbReference type="EnsemblBacteria" id="AFK07295">
        <property type="protein sequence ID" value="AFK07295"/>
        <property type="gene ID" value="Theba_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1631"/>
    <dbReference type="eggNOG" id="COG1583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089858_1_0_0"/>
    <dbReference type="OrthoDB" id="908607at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005054">
        <property type="entry name" value="PF1131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="259" mass="29390" checksum="EB01B6938344400A" modified="2012-07-11" version="1">MRVKLTLSGLKNKAVPRDHFHQLSGLIYAMIQKANPDYSKWLHDEGFLDGSKSFKFFCFSKLIPEKNAYIKAGDNGEMIVFTKDIAALYISSPVREIMQHLVDFLLLNREIRILNHNLVIQNAFASTESFESEEELFKCITPIVLSTRNDEHKTPFYLRAYQDPAQFGEFLTKNAREKFRVFSGRESSVSIVVDGEYVEKVGRKSNIRINIVDDIEVFGSVVPVKISGTGEEIAFLYDTGLGEKNSLGMGMIEIAGKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5W9</accession>
    <name>I2F5W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1659</name>
        <name evidence="3" type="ORF">Theba_1736</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731217.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07322">
        <property type="protein sequence ID" value="AFK07322"/>
        <property type="gene ID" value="Theba_1659"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07393">
        <property type="protein sequence ID" value="AFK07393"/>
        <property type="gene ID" value="Theba_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1659"/>
    <dbReference type="KEGG" id="mpg:Theba_1736"/>
    <dbReference type="eggNOG" id="COG3056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193818_0_0_0"/>
    <dbReference type="OrthoDB" id="31161at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="108" mass="11803" checksum="B0424B8798A6E6DF" modified="2012-07-11" version="1" precursor="true">MKSEIFSFCLLVLIAAVVLFISRCPPVPNTLPTITKASSPSGAISQNSSTFSWNGSDPDGTISKYEYRKDGDSWVRMARAQAIHGVDTLKACTHSKARLRTTKVLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X0</accession>
    <name>I2F5X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1660</name>
        <name evidence="2" type="ORF">Theba_1737</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">MesG1.Ag.4.2</strain>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07323">
        <property type="protein sequence ID" value="AFK07323"/>
        <property type="gene ID" value="Theba_1660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07394">
        <property type="protein sequence ID" value="AFK07394"/>
        <property type="gene ID" value="Theba_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1660"/>
    <dbReference type="KEGG" id="mpg:Theba_1737"/>
    <dbReference type="HOGENOM" id="CLU_1862816_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="137" mass="14815" checksum="0A80BAF25F88F340" modified="2012-07-11" version="1">MGSPVQSHPELVSGSGFDPLGGAGRSLTDNVVFSSVHPLFPREAGIATWAVLAQPCVQCSTTVSLLNGVGSASAEGFLRTKSKALSSRMKIYLIAKKAGLTECKKWSHERTKEAIYRKYIGILSEMGTNFPKGYRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F638</accession>
    <name>I2F638_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1657</name>
        <name evidence="8" type="ORF">Theba_1734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
            <strain evidence="8">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731215.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1657"/>
    <dbReference type="EnsemblBacteria" id="AFK07320">
        <property type="protein sequence ID" value="AFK07320"/>
        <property type="gene ID" value="Theba_1657"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07391">
        <property type="protein sequence ID" value="AFK07391"/>
        <property type="gene ID" value="Theba_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1657"/>
    <dbReference type="KEGG" id="mpg:Theba_1734"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_3_0"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="344" mass="36968" checksum="8139B8E1400E2B21" modified="2012-07-11" version="1" precursor="true">MQAARTLSLRKLLLSLLLVVCILSVWALIIWFGGESPFKGFSFIIEGSLGNHYQLLSTLNKMVPLILAAAAVAVPAWTGMWNIGGEGQLLLGAFGAALVGFSIDFGAGIVNIVVALLVSAAFGMAWAAWPAIFKIKLRMDEVVTTLMGNYIAAQLIAYLINKPFRDPRSPLAQTPYIKSNYVIPYLFEGSQFSATFFIAIGIVLVLFVFRKKFIMGYEFEITGSNSVFAELSGVKVKKIKLLSMLIGGALAGLAGGLLVLGMTQRVMQSFPPGYGFTGLLICLLAFNDPLIIIGIAFLFSVLQTGSVNLQLFSSVPAEISGVLQAVMVLFVAAFKTFIVGRGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F699</accession>
    <name>I2F699_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multisubunit Na+/H+ antiporter, MnhC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731283.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1801"/>
    <dbReference type="EnsemblBacteria" id="AFK07452">
        <property type="protein sequence ID" value="AFK07452"/>
        <property type="gene ID" value="Theba_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1801"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_1_0"/>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="11955" checksum="EC23CAE8D45B0F88" modified="2012-07-11" version="1" precursor="true">MIQYFSMMLVAVGLYGLLSQKNLVKLIISLNIAEIGVNLFIVSIGYIEGGAAPILSSVSDNSSLLFVDPLPQALVLTSIVIGVGVTALALSLIVSVSKSRGTIDISELSSGGGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E9</accession>
    <name>I2F6E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488334.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1852"/>
    <dbReference type="EnsemblBacteria" id="AFK07502">
        <property type="protein sequence ID" value="AFK07502"/>
        <property type="gene ID" value="Theba_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1852"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1307838_0_0_0"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="211" mass="24497" checksum="972745C1866C8388" modified="2012-07-11" version="1" precursor="true">MTNRKAAALRVIVEVGFLFLFFFLLRSRDLQKWFLIFGIGLVGALFLGRFYCGWICPMETLFRPINWLYSKLRVKRLKTPAIFKNNVFRWSILVLFLLLMVAVRIFKIKVNLLLYITAFSVLITLVFEEEFWHRYMCPFGTLLSLFSRKPLFGMKVEKPPCVSCGICQNVCPVSAIETEEDGMKIDTSECLVCLKCKESCPKISIKYSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G0</accession>
    <name>I2F6G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-Pro dipeptidyl-peptidase (S15 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK07513"/>
        <property type="gene ID" value="Theba_1863"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1863"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658688" evidence="1">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S15" evidence="2">
        <location>
            <begin position="44"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="33571" checksum="EEA68B48C9443616" modified="2012-07-11" version="1" precursor="true">MKKQSLLSALLIMLMISLSISCFATSIDSNHIVTESEVHFFVEGERINGILTRPESSEGPVPVVVLLHGFLGHMDDLTVYGSEESLYRMTARLFAEKGLASLRFDFRGSGTSDGEWKDTTFTKQISDAISSIDFLSLAEDLDSRRVGVVGLSQGGLVAACLAACDSRVKSVALWSAVAIPVHTYSALLGKDSVDRAIEADPLEEITAEISWGGTTVLRKEFFDELFLIDPVAEIVSYDGPLLVVSGSKDDLVFPQPEVSNLFTMYHKGVDRLLQQDSGHIFDLFERQDKVLEIIDATLEWFLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G8</accession>
    <name>I2F6G8_9BACT</name>
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        <submittedName>
            <fullName evidence="1">HEAT repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1871"/>
    <dbReference type="EnsemblBacteria" id="AFK07521">
        <property type="protein sequence ID" value="AFK07521"/>
        <property type="gene ID" value="Theba_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1871"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028098_0_0_0"/>
    <dbReference type="OrthoDB" id="1502828at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="425" mass="47287" checksum="16DD999D8E70AF91" modified="2012-07-11" version="1">MNPKDIRKMLQAIEEEIFSRAEMNVKDMLESPSAYVRARAIKSAVERDMKIENIESFLDDPSPDVRKNAVSSMAKFGEDRDSILKALDDPSDLVRSATAKELVEFGYEDEELARKIAADPSKKVRKTFVISLAEAGESELLQEFNGDPSTDVRRILSAYNGELQLDEEVLSSLSGKFQKLAIHSRLGKLDSTSSEKLLGLIKDFRISKTKQILVESLEPFPEEVSVPALRKLVESEDSNVAITALKTYRKIKGYDVSLLQAAERFMDSDDEEMRFVGAQYVKGLLEPSAVDILREGLNDPSDRVRAICIEALANLMDNSISDVIDESLRSTSSRLKKASLRAVKKLKTLDVGDHVSRILSNRKEELQTRILASSVTGLLKLDGLLPCLEEIVVDASSESRLRLSSARAMARINPSRLADLFGFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N8</accession>
    <name>I2F6N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488164.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1946"/>
    <dbReference type="EnsemblBacteria" id="AFK07591">
        <property type="protein sequence ID" value="AFK07591"/>
        <property type="gene ID" value="Theba_1946"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1946"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="259"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="464" mass="51455" checksum="6EA7F9A0303C0EF3" modified="2012-07-11" version="1">MTMSDLRRSASDFWKEFRKVRSGMIGLIFLVVFICILIFEPIIVPYPEVNEKWRDITYWQDLPSSAPPSWINLFTSKKRAVSETIEKYTFSETLAGAMRIQEYVFEYDYSASVAPSDVVFHASGVGKPTVVISIERPDGLSVDLYRKQLETSPSQDARVSIDRSAQTSAMNFGKKYSPSEGVPLQTIKTTDVLFSKAQEGIFRNPEPLVGTYRLKVTLLLQKPDERIDNVFISIAGRVHGILGTDNSKRDIWSGVIAGVKWAMLIGLLTALVSVSIGVVYGVISAYVGGWKDSLMQRIFEIFISVPMLPVLIVMSAVFKPNIWVMIGIMCIFYWVGPVKTVRSMGLQIKEETYIEASRALGASNTRIIFKHMVPLLIPYAFASMALNVPGAIVVEATISLLGLGDATIVTWGQILQAANSGGAMLSGMWWWVVPPGLAIAFMGMTFAFVGFAMDKILNPKLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q0</accession>
    <name>I2F6Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731398.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07603">
        <property type="protein sequence ID" value="AFK07603"/>
        <property type="gene ID" value="Theba_1958"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1958"/>
    <dbReference type="HOGENOM" id="CLU_2142932_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="112" mass="11736" checksum="41B72A1967A2E1A3" modified="2012-07-11" version="1">MDMKPFVWSNGTSTPNGVMTVTNGGLAGHSGKDVNLNNITVSFKFPVNSSAVILYYGEYGGNINVEINGILENVQDFLDINGKVIGGVTVTLTIVSGPGGVLNLQGTITSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T8</accession>
    <name>I2F6T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488056.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1998"/>
    <dbReference type="EnsemblBacteria" id="AFK07641">
        <property type="protein sequence ID" value="AFK07641"/>
        <property type="gene ID" value="Theba_1998"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1998"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052035_0_0_0"/>
    <dbReference type="OrthoDB" id="550571at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="399" mass="44812" checksum="441BD08C33E707E8" modified="2012-07-11" version="1">MPGLSHDSYDIVVGIPSFNNETTIKYVVETAAIGLKQYFPSMRGCIVNADGGSTDRTKEMFYSASSNGVDLLSFVYEGISGKGSAMRSIMEKSKSYGAQAVLFLDSDLRSVEPFWIERLASPILEEGAAYVTPYYIRHKYDGTITNSICYPLTTALYGKKIRQPIGGDFGVGRELLEYYTTVPENTWRSDISRFGIDIWMTTSAVNEVKGSIYQAALGTKIHDVKDPGKQLGNMFKEVVGTLFSLMQKYEDNWKTVGDYSDSPIYGDVVTGIPEPLEVDLENMISKCYEGIHSQEDFIKDILGAKIARNLLLLGKSDAMIDDDLWVRIIYRIASGYRKLALRDRLIELLVPLYFGRVASFVSRTEKMTQEGAEEEIDKLLKKFVETKDELISIWEKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U2</accession>
    <name>I2F6U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488048.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2002"/>
    <dbReference type="EnsemblBacteria" id="AFK07645">
        <property type="protein sequence ID" value="AFK07645"/>
        <property type="gene ID" value="Theba_2002"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2002"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="224" mass="25383" checksum="046396133BA1F0DE" modified="2012-07-11" version="1">MKVLIVDDDLDILNIVRTACENESMQTSTAANAEELWSSLRSEKPDVILLDIMLPDANGLDLVKKIRTMYSRIPIIFLTARKSDLDMILGLELGADDYVTKPFNPRALVARIKAVMRRTEISGTLEDKLTIGDAVVNLKSYTVTKNGKSEELTRREFELLKLLAENPGRVFTREELLDKVWGMDFFGDFRTVDVHISKLREKVGEGFIKTVRGVGYKFVIGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U4</accession>
    <name>I2F6U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731431.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2004"/>
    <dbReference type="EnsemblBacteria" id="AFK07647">
        <property type="protein sequence ID" value="AFK07647"/>
        <property type="gene ID" value="Theba_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2004"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="28464" checksum="01CB07C0866C7C0A" modified="2012-07-11" version="1">MDEPIFKIEKLNVYYGDKHALKDVTCEIPKKKVTAVVGPSGCGKSTFLRVLNRMNDLIPSYRHTGSVKLLGNEILDMDPVILRKHVGMVFQKPNPFPKTIQENVTYGPRIHGIKNRKTLREITEKSLKQAALWDEVKDELKKNATNLSGGQQQRLCIARALSVEPDVLLLDEPTSALDPIATQRMETLIEELSDKYTIIIVTHNLQQALRISDYVMFFYVGDLVEFDTTEKITSNPRDQRTSEYLRGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W4</accession>
    <name>I2F6W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2024"/>
    <dbReference type="EnsemblBacteria" id="AFK07667">
        <property type="protein sequence ID" value="AFK07667"/>
        <property type="gene ID" value="Theba_2024"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2024"/>
    <dbReference type="HOGENOM" id="CLU_3404329_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="30" mass="3642" checksum="674D3E7719F86052" modified="2012-07-11" version="1">MKKRNMKEVDRIVLQVRESAFSSLMMNPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X7</accession>
    <name>I2F6X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731461.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2039"/>
    <dbReference type="EnsemblBacteria" id="AFK07680">
        <property type="protein sequence ID" value="AFK07680"/>
        <property type="gene ID" value="Theba_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2039"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089201_1_1_0"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="26"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="276" mass="31193" checksum="B32D3F2F4F3F90E7" modified="2012-07-11" version="1">MNSQAIARELRASWAFIERNFNFTKRYWKWELVFFVYTMANSVTMGFIGKGVEAFSGTKLDTSYLILYMLLGSILWGYLSILFEIVAETVAWERWEETIEYTFMAPVRRATHLLSTCGYAILYGILRSGLILVVVSVFFDLDLGRANFLSAAGILAVSSFSFVGLGIVAAVLPLISPEKGVQVVHIFQALLLMFSGVYYEIDVLPVWMQQVGKLSPATYALRGMRSSILEGRTMAEMWNDVWPLILLGALLLPFGLVFFKRMEVWAKKRGVLKRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y6</accession>
    <name>I2F6Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731469.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2048"/>
    <dbReference type="EnsemblBacteria" id="AFK07689">
        <property type="protein sequence ID" value="AFK07689"/>
        <property type="gene ID" value="Theba_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2048"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_3_0"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="286" mass="31093" checksum="8D969D66AC8DB1F3" modified="2012-07-11" version="1">MIGVVVDSGCDLPDEVKAKDNVREVPLKIVLDGKEYRDNIDISTSDLLEYMENKFPKTSLPRPPEIGEAFESLYEKGYNEILFIGISSGLSGTLDQVKSYVRDFSEKHGDSKIEVVDSKNISIGSGLLAMKAIELIKSGESFEGVVKDILGSVRKAKVFFCIPVLKYLRAGGRIGKVTATIGDILDLKPVITVGEDGVYHSVSKERGMKRAVKSSVEKLIHFIDGNRVLNIAAYTSDKSEKTMELFRMAVSEIKAAGLSHIITGQISQSLVCHTGPGLIGVAAILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y7</accession>
    <name>I2F6Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
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            <end position="160"/>
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    </feature>
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        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
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            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="449" mass="49664" checksum="C193950DF70CBDE6" modified="2012-07-11" version="1">MDRNSQTRILSVFEGAIYNGFFLITQGFLGTGLALEFGASEPVIALIGVLPSVSQLIQLIAPFILRLVGNRKKAMMICASAGRLSTAFIPVTLALGINKQSLLLVILAFFSFAASLAGNFWVSIIRDVVPPDKSARFFSLRNVIFTITNMLITLLYSFILDHSSGKTGFVIITTMGAVSALVSLVLLGLHNDPPHEISYGSGLFKAVTRDKKFMTYLRFYSFWSFSIAIASPFFAYHELVNMELDYSFLSLLNIFSSTLTMVFYLLWGRIADRIGGQAVLEFGILGAFLKTFLWLFMDRGTVYLLYIDTFIGTASWSAINLCLFTTMLELLNGVDAETYYALLSFSNGASALAGSLVGGVLAFYLNKFTWTLGGHTFFGIQILFLVTLVLRGVSFLLLKRVKTKKVVSVPGMVFNSAVVIANRLAARPREFIEVMIEKNKSRRRSDNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F718</accession>
    <name>I2F718_9BACT</name>
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        <submittedName>
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        </submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07721.1"/>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
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        <property type="gene ID" value="Theba_2087"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657809" evidence="1">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="320" mass="35186" checksum="8DCBFF873C661823" modified="2012-07-11" version="1" precursor="true">MKKAFVLTILVVFILSAFAMAAEKIKIGVAIPSADHGWTGGIVWWAQRAIKDWSEKDPDIEFFLVTADSPAKQVGDVEDLMVKGIDALVILAHDSEPLTPVVEKAYNSGVFIVSVDRGLTKPVENVYVAGDNPGLGRVSGEWLAEALNYKGDIVVLEGIPCVINSERVDAFNEVMAKYPDIRILDSQPAYWDTARGLEIMENYLQKYPKIDAVWAQDDDVLVGVLQAYKESGRNDIKLFLGGAGSKQMIKKIIDNDPLVKADVTYPPSMIATGISMAVFALRGQPLEGFYQQQIPSKIILAAELITAENAELYYEPDSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F720</accession>
    <name>I2F720_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">Theba_2089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AFK07723"/>
        <property type="gene ID" value="Theba_2089"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="251"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
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        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="497" mass="55573" checksum="7041C24149804D63" modified="2012-07-11" version="1">MGEVLIETKGISKEFSGVRVLDNIDIGIERGEIFGIIGENGAGKSTLVKILSGIYTPTEGKIFFEGKEVEIKDPLHAKMIGISIIPQEFNLINELSVYENIFLGSEITRKGFLNTREMKRRTISLLEELKKSIDPEEKIERLSVAQKQMVEIAKAIAYDSKLLIMDEPTTVLTLNEIEILFDLMRSLKERGVTIIYISHKLKEVRKICDRVMVLRDGQMISVSQTGEVDEEEMAKRMVGRELSQIFPDKVSPSDEVVFEVENLTINGLLENISFGLREGEILGFAGLVGAGRTELAEAIIGIRKRDSGKISIKGKPVEIKSPNDAVKNKIAYLSEDRQGSGILTSFDLIKNTTLISLPAYSKILINSKKEREKTKKYVDKFNIRAASLKTRLEFFSGGNQQKVSLAKSLDPEPDIFIFDEPTRGIDVNAKREIYRFMNELVNEGVSCILISSELEEIIGMCNRVVVMKEGRITGILEGEHINEEEIMLHATGLKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F745</accession>
    <name>I2F745_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2114"/>
    <dbReference type="EnsemblBacteria" id="AFK07748">
        <property type="protein sequence ID" value="AFK07748"/>
        <property type="gene ID" value="Theba_2114"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2114"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149200_0_0_0"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="131" mass="14610" checksum="14DCE187C74C5CB5" modified="2012-07-11" version="1">MMTKVMIRLRMSLNDAHYGGNLVDGARILQMFGDVATELLIRNDGDEGLFKAYDNIEFIAPVYAGDYIEATGEIISSGNTSRKMLFQAFKVVQTRPEINDSAAELLSEPVLVCRASGTCVVPKSRQRKRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G9</accession>
    <name>I2F7G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731631.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2243"/>
    <dbReference type="EnsemblBacteria" id="AFK07872">
        <property type="protein sequence ID" value="AFK07872"/>
        <property type="gene ID" value="Theba_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2243"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_0"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="37973" checksum="3FCD5237A684BC58" modified="2012-07-11" version="1">MKFGRLRVALIGAGQIAEVTHLPVLSEMSDRVELVGIADPAVERAVMLSSRFGIDNTFGDYNEMLSSLNPDAVFVCTPNKFHSAATVSALRSGSHVFCEKPPAINAREVQEMMVASKEAGKILSFNFHYRFRSEAIAIKKFVDSGDLGEIYFCEATALRRRGIPGWGSFTNKEIQGGGPLVDIGVHMLDLALHMMRFPQPKSITASAYCKIAKRSGVGLMGGWDPEKYSVEDSAFGFVRFHNGASLILKTSFALNMKDRSIMNLQIFGDRAGATVFPPEVFAESHGELTNTAIPFAESKDCYKRSVESFIDSCLGKESTIPTPEEALAVQSILDAFYLSAESASTVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H5</accession>
    <name>I2F7H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731637.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2249"/>
    <dbReference type="EnsemblBacteria" id="AFK07878">
        <property type="protein sequence ID" value="AFK07878"/>
        <property type="gene ID" value="Theba_2249"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2249"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_1_0"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="28974" checksum="F0BE58045C1F22FB" modified="2012-07-11" version="1">MEDYREPVGLEGRFQYHIECSAGDIAPVVIVPGDQGRVDKIVAGLSEARKIAENRGLITYTGKYKDYPVSVTSTGMGGPSASIVYEELINVGARVLIRIGSVAGLQEYVNEGDIVVPYGCVRDDGASNYYVPPNFPAVPSPDVYSSLTTSARERGREIVTGINWTHSCFYKRDPEYFQSWSKRRIVSLEMEASALFVISYLRNVKAGFIGICYANRYKQSAGTKVDLSVKNPRRDVIENSVKETIEITLTAIKKMYDEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K2</accession>
    <name>I2F7K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731664.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2276"/>
    <dbReference type="EnsemblBacteria" id="AFK07905">
        <property type="protein sequence ID" value="AFK07905"/>
        <property type="gene ID" value="Theba_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2276"/>
    <dbReference type="eggNOG" id="COG5361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027269_1_1_0"/>
    <dbReference type="OrthoDB" id="547506at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658419" evidence="1">
        <location>
            <begin position="23"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1254" evidence="3">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="337"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="467" mass="52132" checksum="6847E03BA0397F70" modified="2012-07-11" version="1" precursor="true">MASKKLLILCVLFITFLSTVYSSQHDLTTDPYEASLVAKDAYIFAYPMLENYRTMYGEAVDSGVFNTFNHVKTIFGPQSRTVVRPNNDTIYSTAWLDLRAEPIVISLPAVSDRYFSLQLVDMYTHNFAYAGSRTTGTGAVTVMVAGPYWDGEIPSGIDNAFYSEGNYVYCVVRAAVNSERPGDLQTILQMQQKYSLQPLSTYCGEPEPSPLEAEDFPLFDQTVADSVGFIGYFNFLLGQLKIHPSEEALIERYSEIGVGPDFVFNPADLTEPVNEAIESAIAQARQEIYHPGTAIGSITNGWSLPGRIFGNRERMQGNYFIRATAAHMGLYGNDLEEAYYPSSFFDSDGEPLDASKYNYMITFSQDQLPPVDERGFWSITMYDADQFMVENPLDRYSIGDRSELVYGDDGSLVIYLQHKSPGESKESNWLPAPDGKFTTTLRIYIPLPEGLDPLYCPPAVRKAGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L8</accession>
    <name>I2F7L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731676.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2293"/>
    <dbReference type="EnsemblBacteria" id="AFK07921">
        <property type="protein sequence ID" value="AFK07921"/>
        <property type="gene ID" value="Theba_2293"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2293"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408695_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="699" mass="79210" checksum="83D302E68BF1EE12" modified="2012-07-11" version="1">MATVKIEDQKFKVDGKEISMYSGSVHYWRSKPEAWSGILDKVKDMGFNAITTYIPWEIHELQRGVFDFGEVEPSRDIDRFLTLCEEKGLYFAVRPGPQINSELTWFGFPERILEDPKLQARNAKGGKVVLTQVPRPIPALAYHSEEFLAEVDLWYDAIFSILEKHQPPKGNLVAVQVDNEMGFFFNVNPYSTDYSDSSKALYRSFLKEKYNTVSELNKMYSSNYSGFDEIDPPGRFEGTRKEELRYYLDWIEYREFYLITSMENLGNRMKSRGIHVPLFHNYPHPLGPGGAKGAPTTPFNLPALEEKLGFVGFDIYSRKELYDHVKTIASYVSGCSRFPYIPEFIMGVWPWYIKPGDVTDEVFVTKEALMHGIKEFNRYMLVDRNKWLGSPINRKGVVKEDSYAAHKKVGTNLMKIRWNDFAKCDDVLLVVNRDYDRLEAATTLLPVVGDFLEPVFGFSEYPSSVIVSDENLGFRRPIQQHKSTWFDAFYRALTEGGVVFSLGDTAQSVEALKKHKVLVISAFDYIGKKTADKLAEYIETGGTVVLGPEVPKLDDTFSSESALSKLVSSTTGKPVLNSNGMEIGKKFACGKGSLIQIFELESVSSGLIEILDSVKVFRIDKGKSVADLVLYKGKTSDEYILFVANPSDKKIEIDIPLPSVSESITDIWEEKKEQISAGRLVTEVCAHDIRIFSWKAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R2</accession>
    <name>I2F7R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">X-Pro dipeptidyl-peptidase (S15 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731715.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2340"/>
    <dbReference type="EnsemblBacteria" id="AFK07965">
        <property type="protein sequence ID" value="AFK07965"/>
        <property type="gene ID" value="Theba_2340"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2340"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_0"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S15" evidence="1">
        <location>
            <begin position="151"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="45371" checksum="7D417CC6484300F1" modified="2012-07-11" version="1">MEDNSKGVSRGSLDVRILRDVEFDFQLYRSLGAVSYEGGTVGEILSLVPHIDCDDPDSWVKSFKELATKLKNHALVVLQKGNNESARQEFLRAASYFRAAEYFGDPRDSKTRYLGMESRDCFVYAFRTTDIQFEAERIPYGEDFIPAYWIAPTTGGKKKTIMMMSGFDGTSEEMYFQAGSAALQRGYAVVLFDGPGQVGMRRFSPETPLRPDYEVPISKVVDYALSKEDVDPSKLALYGISLGGYFSLRAAANDSRIRALISNSPITDMYKYMSAFAGEAINSPEDITLETVDLVPTEYLSKAQKLQLVNIMLKYGRHSMFKAFERMKDFVVGDSIKNIQVPFLAMVSEGEGEEALSQAKEASDSVSGKSTMRIFTREEGADSHCQVTNLPLSNSVLLDWLDEVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z9</accession>
    <name>I2F7Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489886.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2439"/>
    <dbReference type="EnsemblBacteria" id="AFK08052">
        <property type="protein sequence ID" value="AFK08052"/>
        <property type="gene ID" value="Theba_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2439"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="32029" checksum="9ED063B2FD80BD85" modified="2012-07-11" version="1" precursor="true">MEKTVKVSKPFMDDLKHTAFLWRKSRLTMIGSAIILVFLLMAAFAPLIAPYDPVHQDLQIKLQAPSWQHLFGTDQFGRDIFSRVIMGSRIALWIIFLVSVISGSIGIIVGVTAGYFGGIVDEVLMRITDMFLAFPSLVLAMAFAAMLGPNLTNTIIAISIVTWTTYARLSRAEAIKVKSQPYIEAIRAAGGGNLRIMFLHVLPMCISPVLVQLTLRMGTIILTAASLGFLGLGVQPPTPEWGAMVSDGRNYLIDQWWISTFPGIFIAFVVLGFNLLGDGIRDMLDPRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F803</accession>
    <name>I2F803_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731791.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08056">
        <property type="protein sequence ID" value="AFK08056"/>
        <property type="gene ID" value="Theba_2443"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2443"/>
    <dbReference type="HOGENOM" id="CLU_1832792_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="140" mass="15931" checksum="3353E1D24E8F032D" modified="2012-07-11" version="1" precursor="true">MKRIILITSFMAILLMLLSGCFFIDPMVKVTKLVSDFEEYWEDENAVGLAGLYTDPALINTAMKSYLQIIDAYSSRFEGRDVVSFNRGDVDVHFNVGATEATVEFSAVIDWTSGPDDHRTYSWTVKKMSGNWFISRSNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F808</accession>
    <name>I2F808_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489863.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08061">
        <property type="protein sequence ID" value="AFK08061"/>
        <property type="gene ID" value="Theba_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2449"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050659_1_1_0"/>
    <dbReference type="OrthoDB" id="1497065at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="402" mass="46719" checksum="F6FBDE0CCE79BD85" modified="2012-07-11" version="1">MEIRRIDSSYKDKIVEIFLMSFEYFEPEESEFFFSDPSLWKYVWGAFDDEKLVAAYISYKYLAKIRTKPFECRYVEAVATLPEYRNKGITKAILLKDIQEALQSGVNFLMLDPFKHDFYVRFGFGLGFESLDFKFDFSLLSDEIEEDNLNIVSGKLLNSAEMQELIEKARKVLWETSRYTEAIEINACSQEIFHMKDLFGAVAVDKAGMPHAMMVYRKKERKMKVSNFSFIDLAGLFALKRFMLNHRDQIATFEMNRMPPDFPVELFFHSRWQAGKDLKIEDASSRMVRILDPLPVIKELMNRSISETVVIKIKDKLLPQNNLTIEIGKGTARLSEAPNDLEITISDLTPLLTGRLSPTRLWRHGRLRTDSWKNVPWGISEVPEKVKVLESIFPPFITHNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F835</accession>
    <name>I2F835_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731820.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2477"/>
    <dbReference type="EnsemblBacteria" id="AFK08088">
        <property type="protein sequence ID" value="AFK08088"/>
        <property type="gene ID" value="Theba_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2477"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014011_0_0_0"/>
    <dbReference type="OrthoDB" id="827189at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043751">
        <property type="entry name" value="DUF5696"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18952">
        <property type="entry name" value="DUF5696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="709" mass="79035" checksum="B4ABB613DE0C07CD" modified="2012-07-11" version="1" precursor="true">MRVNRAVVGYAIKIALLVLATVLLGLLLDYEPGESLGTPPVAFVQRPYTFESPVFEKILGNENLELYFDKRSAGIKLVDLRNGKVWHSVLEEADRSLNNVWQAFFSSGVTLEHIDARNTVRRLNSVRDGETGFVDLSSDSFSVAIAFPDVGAAIEVKYTLGVDSLDISVTRVEEGAIKLTSLYLYPFMGASKGTVPGSFLIPDGIGAELNLSKKTIATSPFIARVYGRDEGFTDIPTTFSLDMVTDPERITLPFFAITAGDSAMLGVIAGGDLYAEVQAYKSGIVTPFNWITTRFIYREMYRKLLNKKGEGVSIPQAQRNAVSPTLRFYFLDGKNSSPSGIAAKAREDFLRRGLIPSRRLEQVVPLKLEFLVSESEKTTFGRKVHIMTPQSELEKILTDVRRYSQRTVVVLRGYTSGGLSTSSPDHLPLERKAIEDISRLSDFYFYVDYLTAYEGSGGVSRARYAQNRSEQIMIDGPRFIIDPRETASFVLEELESFSKLGIEKFALANLAELAFSTRDSNRTENVEALLETVSLFDGPILYNPNLYMISRASHVSDIPVSNSGYLIEDSVVPLLPLVLRESFWLFTAPINLTSDFRRELLRAVDYGLFPGFYITFESSMKLVETASSDLFSTGYESWSEKIEFAYDFVSKALENTVGSRLVERVEVADGLFRNTYDNGTSITLNYNENPARAGDLEIEPLSYVVEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A6</accession>
    <name>I2F8A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ORF">Theba_2559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731880.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2559"/>
    <dbReference type="EnsemblBacteria" id="AFK08159">
        <property type="protein sequence ID" value="AFK08159"/>
        <property type="gene ID" value="Theba_2559"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2559"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_4_0_0"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK08159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="22690" checksum="19350BDAA5E162F1" modified="2012-07-11" version="1" precursor="true">MEILFSALLAYLIGSIPTAFLIGKSLYGFDIRKQGTGNMGASNMVAVKGWKIGILTGAIDFMKGLGTILIIKGVSPHWTYQMLFIAASFAAIGHMYPVFLRFKGGKGTATLAGGLIGLDYQVALICMVILLAFIAITDYAAPGIIAVSSVMIFLFRIFGYRWGISLLLIPIAVIMIARNLENIQRILRGEEPGLRAHIRKKKRAPQKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C5</accession>
    <name>I2F8C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731896.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2578"/>
    <dbReference type="EnsemblBacteria" id="AFK08178">
        <property type="protein sequence ID" value="AFK08178"/>
        <property type="gene ID" value="Theba_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2578"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_0"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="468" mass="50783" checksum="789BB1B80B02404D" modified="2012-07-11" version="1">MNYGRLNADLIEELQSLLNIPVKYDEESLDRYSRDETAELKAVRPEVVTFPVSTQEVSEIMKFANRHLIPVTPRGAGTGLSGGAVPSYRGIVMSFEKMNRILEFDEANMMITVEPGVITGEIQKLADRHNLVYGGDPCSSESSSIGGNVAENAGGNKVMKYGPTGYHVYGLEVVLPSGEITYFGGKRLKDVSGLDFVHLMVGSEGTLGIVTKITLRLLPKPKYSVALLVPYPDIDTAIAAVPGLMSGSGVVPTSLEFMDGSSIRAACSFLNIEFPYADAGAHLIIEVEGNSKDSIFDDYVKLGEAAIEAGGLEAFVADNRNTRDKLWKARKSIAEALAAISPVHSMEDVSVPMANIPKLIKRSEEIAKKRGLEMIAFGHAGDGNVHVTFIKGDLPQEDWDRNLPLAEKELFDETTELGGCISGEHGIGIKRKKYLASIVDEAQLDLIRGIKKAFDRNNILNPGKIVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E1</accession>
    <name>I2F8E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731910.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2594"/>
    <dbReference type="EnsemblBacteria" id="AFK08194">
        <property type="protein sequence ID" value="AFK08194"/>
        <property type="gene ID" value="Theba_2594"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2594"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_0"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="173"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="342" mass="37615" checksum="A8D01536B38AC850" modified="2012-07-11" version="1">MKAAFVKSPFKFEIREVELPPLKPNDVLLKIKASGICGTDLHTARTEAKDWQTFGHEIVGIVEEIGSCVENVKVGQSVLVESGSFCGTCEDCRNGRVDLCHDRAPNVFIRAEKENLTMGFAEKVIIDKQNAVPFEGVPFEEASLVEPMGVALDLTYTVDPRLNDDVLVVGLGPIGLMAVQIVKAMGARRIFVANHSRSKIRIDVAKSFGVEDVILVDKTPISSYKFPKGGVDRALVTAPPYVIPEVLDVMNFGGVVGFIGIDYGEGRFIKFDANKFHFNKLQLRASHAVPALYFPRCVDMIKSGAVNVKPLITDTFKLEDIGEMMVRAENEKDKVIKAVMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E9</accession>
    <name>I2F8E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489419.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2602"/>
    <dbReference type="EnsemblBacteria" id="AFK08202">
        <property type="protein sequence ID" value="AFK08202"/>
        <property type="gene ID" value="Theba_2602"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2602"/>
    <dbReference type="eggNOG" id="COG2377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038782_0_0_0"/>
    <dbReference type="OrthoDB" id="736294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="371" mass="40574" checksum="98C87E5D0047BA4D" modified="2012-07-11" version="1" precursor="true">MIWNEIRDLLSSGTRSILGVMSGTSADGLELAIVNCSGSGKSMKVKLLEHSSVQFESSFHDEIVKTFDPSLSGVDRVNSMNFLIGKRHADAIKSFLNGTEVKVDAIAYHGQTVYHDPAVHATLQIGEADIVSSETGLPVVFDFRKKDMVFGGEGAPIIPYFDWIYFESGIYAVNLGGIANVSYVAEKLEDMKAFDTGPANCLIDLVAKRYFNMEFDEGGKIAARGSVDSAILDVLIERDRRYFERQPPKSTGREIYNETFLEGISFSSPENLVRTLVRFSVFQLVQSINSYLPLGKRIVVTGGGALNPVMIEDLKQLSGLDVEVPDKTFLQAKEAIGMAVLAQEFFNGVEANVPSVTGARKRVVLGKLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I2</accession>
    <name>I2F8I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731942.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2635"/>
    <dbReference type="EnsemblBacteria" id="AFK08235">
        <property type="protein sequence ID" value="AFK08235"/>
        <property type="gene ID" value="Theba_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2635"/>
    <dbReference type="eggNOG" id="COG5421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022426_5_1_0"/>
    <dbReference type="OrthoDB" id="995276at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="523" mass="61263" checksum="6FA49D16E885BD29" modified="2012-07-11" version="1">MFLRLKHFKNKDGSTRSYLQLVENIRVGNKTRQKVLVNLGRVDDLQNSGQIDRLIESLRNFSTKEWIRKEALNVNQTYLWGPVIIFEQLWKELGIERVLRRLLGDTDAVSDYVEAIFAMVLNRLVEPRSKRGVDRWVSKVYRPEFEQLSLQHYYRGLDYLEKFKEEVEEELFSNVKTLFNLNLDLVFWDTTSTYFQGEGPELSMYGRSKDHRSDCKQVMIGVLMTKDGFPVAHQIFPGNTADIDTFRIALEDIRRRFNIDRVIVVADRGMISNGLIEEIDKAGLSYIFGVKMRRSKRVEAVLNQPGDYEEVEENLKVKEVLHEGERYVICFNPFQAERDRIKREEIVKNLTKKLKQGPKSLVGNRGYRRYLSMQKTDVKIDQEKMASEIKYDGKYVLRTNTKLTNREVAQSYKLLWKVERAFRELKSGLDLRPIYHYTDTRVKGHIMICFLALVMETALCRKLKEIGSTFSYAEILEDLKEIRAVEITVENKRFLARTETMGNAYDAFKALKIRPPDLLKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I5</accession>
    <name>I2F8I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731945.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2638"/>
    <dbReference type="EnsemblBacteria" id="AFK08238">
        <property type="protein sequence ID" value="AFK08238"/>
        <property type="gene ID" value="Theba_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2638"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="34867" checksum="83575A6A2CB0E698" modified="2012-07-11" version="1">MPRTVVEVKDLKKYYGETKAVDGIEFDLREGEVLAILGPNGAGKTTTVEMLEGLRKPDHGTIEYFEERLPPSSDRVKEEIGVQLQSSSFFEYLSVKETLDLFRGLYRKSIPSKDLIREVSLQDKEKTYTKNLSGGQLQRLAVAVALVNDPRVVFLDEPTTGLDPQARRMLWETISVLKQRGKTIILTTHYMEEAERLADRIMIMDQGKIIARGTLFELIDSIEVENIVTFSVRGDGPIPNEFLEIEGLQHTENREYSVTTRDVERTLGRLFERSKRFDLLLDDVTIRKPNLEDVFITLTGKKLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J5</accession>
    <name>I2F8J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_2648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487248.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2648"/>
    <dbReference type="EnsemblBacteria" id="AFK08248">
        <property type="protein sequence ID" value="AFK08248"/>
        <property type="gene ID" value="Theba_2648"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2648"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OrthoDB" id="1071222at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="574" mass="64320" checksum="325DABC9EF7403C6" modified="2012-07-11" version="1" precursor="true">MENEKKTVRRFVFKLFKVYWKRELLAAVLVGVMIALAVVFPLLIRLLIDVVIPSGDMDLLVKYVLLVVGLWFGSLIFTYFGEVVFETTALMAKSDLRKQLLEKMFVLPFDFFHKNKTGELVSRLISDLELVGTVIAQVFPILLLGVVQITAILAIMFAFNWKLTLLPLGFIVFSFLVIMFFNIMVEKRSKVEREKFGELAGVTSNIIDNMKLIRIAMPFAWVMNFFDRFQGDHIYAGKRFIKSIKIAGTLKTSINGLISFSLLAYGGYLVMKGEITVGILMTFWAYVQSLFNPIQLLMQVNILLRQSWGGLLRTIEVLEAPEEERSNSSPKLEDVRSISLENIAFGYGNKQILKGLSLELRKGEITTLVGESGAGKTTTLNILMGLQKPQSGTIYINGDPVSNSALLRPYIGFVEQTPTLFEKCTLLENITLGRSISKASLENIFERTNLDVLLRRFENGLDTLVADIQLSGGERQLVALARALVSNPRLLILDEITANIDSKTEEIIQNTLLGLRSEGIIVLMVAHRLSTVLLSDRVALISNGVIVASGTHNELLKTSSEYKKLYSLQLIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M3</accession>
    <name>I2F8M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate/lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731971.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2677"/>
    <dbReference type="EnsemblBacteria" id="AFK08276">
        <property type="protein sequence ID" value="AFK08276"/>
        <property type="gene ID" value="Theba_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2677"/>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_3_0_0"/>
    <dbReference type="OrthoDB" id="1374098at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="360" mass="38976" checksum="81029B032BC80455" modified="2012-07-11" version="1">MGKPVAYENLRRLCEEILLSENFGIEAAHEIVDVLLEADLRGIPSHGVARLGRYIKERDSGNILLDSKPSIVHDTPVSATVDGNGGPGQCVSNYAMDLAIRKGKESMIGLVSVRNSNHYGISAYYSEKALSKKMIGIAMTNSYPLVVPTFGKEAVLGTNPFSVAIPGLKKNFILDMATSVVTRGKLEVYDRLGRDIPNGWAVDETGRNTTSPRRVLNNFNSRNPGGILPLGGSEEDFGGHKGYGMALLVDLLSAGLSLGRWSAETYSGSQAGVSHFFGCFSLELFGDRSSLIEHLEHIVDGVVSSKKADGHNKIYYHGEKEAMARERAVTSGIDLDQKTRDSLVSLAKKHSLSIPVELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P7</accession>
    <name>I2F8P7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sn-glycerol-3-phosphate transport system permease protein UgpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487334.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2701"/>
    <dbReference type="EnsemblBacteria" id="AFK08300">
        <property type="protein sequence ID" value="AFK08300"/>
        <property type="gene ID" value="Theba_2701"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2701"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015794">
        <property type="term" value="P:glycerol-3-phosphate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030165">
        <property type="entry name" value="UgpE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43744:SF8">
        <property type="entry name" value="PTHR43744:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="31081" checksum="C62BAFE41BFA72BC" modified="2012-07-11" version="1" precursor="true">MKKSTRKLVNTIIIEIILITVSFIFIMPVILAITMSLQPPQSVFSFPPKFFPTAFHIQNYFDAFKTVPFARLLLNSAIVSLAITLGKLVTGTLAGYAFSNFRFAGRGLAFGFLFATLFLPAETIMIVPLFSLMNKFGWVNTYWALTIPFMASATNTFLMRQQFMTIPLSLEDAARIDGAGPIKYFLKILLPLSKSIIAGSAIINFVYSWNIYLWPLIVTMEDKMKTVQIGVKMLIDAESANNWGIIMAGTMVAVIPTLVVFFLLQNLFVKSLVGTGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8Q5</accession>
    <name>I2F8Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732001.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2710"/>
    <dbReference type="EnsemblBacteria" id="AFK08308">
        <property type="protein sequence ID" value="AFK08308"/>
        <property type="gene ID" value="Theba_2710"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2710"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890942_0_0_0"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="307" mass="35534" checksum="B991866F51C834C6" modified="2012-07-11" version="1">MKIQGYSKDFKQRMLDIQLDYERNHPDAEKFTADDFRNPLLNGRKNILLAVDNGRVLGFSRFFARQNFSREFFHHIWLEIILEHFADPDLMSALYKASIPLIIESTKGFFPAAGKRICVKIADTEKTKSDFFSSVGFTHWIDFIYMEKDLSEEISSYSLPEGLNIAKLKPRREPEILQYLRVEQICFPDSPLEYKYLNYFFSRAEWRREGVIIAAIDAGGNIAGSVMIYPDAQNSDKCYTEEIFVVQEWRGKGVARALLATSLTYLKKLGKTRAILSVTSDRTSAKKIYEEAGFKFRLKRRVLALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R2</accession>
    <name>I2F8R2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoaspartyl dipeptidase</fullName>
            <ecNumber evidence="1">3.4.19.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation allows a single lysine to coordinate two zinc ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M38 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732008.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2717"/>
    <dbReference type="EnsemblBacteria" id="AFK08315">
        <property type="protein sequence ID" value="AFK08315"/>
        <property type="gene ID" value="Theba_2717"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2717"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058216_0_0_0"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010229">
        <property type="entry name" value="Pept_M38_dipep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001238">
        <property type="entry name" value="IadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01975">
        <property type="entry name" value="isoAsp_dipep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="55"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="372" mass="40310" checksum="A6015CB37CBA9E67" modified="2012-07-11" version="1">MITLFKNVEVFTPKPLGKKDILVSGERILEIDERIDESAIVSLNGRVLDLSDAYAVPGFVDGHVHLIGGGGEGGFSTRTPEGSSKQFLEVGTTTVIGLLGTDGITRDHISLLAKARDVQNDGLNAFMLTGSYRYPLKTITGDIMRDIVLIPEIIGVGEVAISDHRSSNLSAKELQRFAMDARVAGMLSGKAGVVVLHLGDGQEKLKPLYEATSDGTLSPTQLIPTHICRTEELLSQGIDWVSSKGGYIDITANEDNTHLVLSDIYRRKIRFDRICVSSDGLGSLPKFDSEKNLVGIKPAPVDTLMKSFIKLISEEGLPIDEALRPFTINPARFFHLAENGIGTLKKGGIASIVFLHRDLSIDHVVSNGRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R4</accession>
    <name>I2F8R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mntP</name>
        <name evidence="9" type="ORF">Theba_2719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732010.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08317">
        <property type="protein sequence ID" value="AFK08317"/>
        <property type="gene ID" value="Theba_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2719"/>
    <dbReference type="eggNOG" id="COG1971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096410_3_0_0"/>
    <dbReference type="OrthoDB" id="1857762at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="182" mass="19451" checksum="1A8F84D3682AD4E0" modified="2012-07-11" version="1" precursor="true">MENLLVATGLALDAFAVSICTGISLPGVTGRHVFRVSFHFGFFQFGMPLIGFLLAAGFRDFIVDFDHWIAFILLAIIGGRMLYESFENQGEEICKDQTKGLTLISLSVATSIDALAVGSAYEFVEKPVIETAKMTGVITASLSAIGVSGGQRISQKMGRAMEAVGGTVLIAIGTKILLEHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J3</accession>
    <name>I2F1J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0043"/>
    <dbReference type="EnsemblBacteria" id="AFK05796">
        <property type="protein sequence ID" value="AFK05796"/>
        <property type="gene ID" value="Theba_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0043"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672136_0_0_0"/>
    <dbReference type="OrthoDB" id="991466at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="195"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="46183" checksum="BBE1D090DF717E57" modified="2012-07-11" version="1">MTKERYVVHYTENAVKIVQTQVSSVRKKDILRTSIRLYDGKSMGVAGALGECNEEELVAKAKESLKLAIPYPYEASRELVREERHRSDLQGEEELLEATEEILQKLRRDQPHFSFSHLFKSARVESSMQNDLGLDLKSSREFISLELVIKDKKSSNIIDAMTGYEGRKFHKDSFIGLTNMICDAYMNQLPDIEEGVYPVVFRSDDMTYYKKLYESLNGMLFGSGGSLLSGKIGKKVFSDKVTLFQTRNVEDGFFEPFFDKEGTVNDSDRFALIEDGVVISPYTDKKTAATFNLTHTGSAGGEYDGLPELGMPMLKFAESHKTAKQLLDGQKAIFILIASGGDFTQDGRFATPAQLAFLFDGDRFIGRLPELSLSSHIFDMLGKDFRGVSSEDFLGIENAKLTIMDMNVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K5</accession>
    <name>I2F1K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729982.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0057"/>
    <dbReference type="EnsemblBacteria" id="AFK05808">
        <property type="protein sequence ID" value="AFK05808"/>
        <property type="gene ID" value="Theba_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0057"/>
    <dbReference type="eggNOG" id="ENOG502ZUWV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2826126_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="66" mass="7018" checksum="3543A11DFB3D2951" modified="2012-07-11" version="1" precursor="true">MNTFLAIVGALFLLYLAIRFFPALIMIVAGVGVIMIVIFAIAGLVAFFLPILLVVGLILVIVKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L5</accession>
    <name>I2F1L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729992.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0067"/>
    <dbReference type="EnsemblBacteria" id="AFK05818">
        <property type="protein sequence ID" value="AFK05818"/>
        <property type="gene ID" value="Theba_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0067"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787097_0_0_0"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="352" mass="39630" checksum="1C367825701313CB" modified="2012-07-11" version="1">MKPAPDFSVILDVFRRNGEPCRVPFFELFADDEIMEEVMGYKLAKLEEDPDRYFDQLVGFYKEMGYDYVPFYQAPRFPTPDYIHGEDTATYRRESRKWMNEKGGPIKTLKDLQEADWPKPEEAVDFDLFRKLGDHLPEGMKVVGGASGGPFEHSSFLMGVENLSMAVYEDPELVNTLNEKIGNVLVGAAKIISSMDCVGAYCFGDDLGYKTSTIFSPRHLRRLVFPWYKEIASVVHANGKPFVLHSCGNLTTVMDDIIDAGVDAKHSFEDQIMPVTEVKRRWGERISILGGIDVDFLCHASVEQVRKRTLETLEQCAPGGGYALGTGNTVANYIPVKNYLAMLEAGNEFNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X3</accession>
    <name>I2F1X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730090.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0186"/>
    <dbReference type="ESTHER" id="9them-i2f1x3">
        <property type="family name" value="Bacterial_EstLip_FamX"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05926">
        <property type="protein sequence ID" value="AFK05926"/>
        <property type="gene ID" value="Theba_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0186"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033707_0_0_0"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657562" evidence="1">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3887" evidence="2">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3887" evidence="2">
        <location>
            <begin position="139"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="537" mass="59911" checksum="11DFBBA3E52CCB7D" modified="2012-07-11" version="1" precursor="true">MFRRILVSTVLIASVLSFASIDVAEQYFNSFFNGKYPEAYELQNAEMKKAQPLSAMRNLRGQLRMQVGDFLRVLDINEVPQGDLVSYLFACEFKAGIFDVIITLDAEEKVAGFFIRPSSYVEPETETVMIETGNEVVDTYINGFFSGKFEEIFELQTEQVKASLSPEALKGAYANIVSMAGEFEEVLNLESSKSDGMISFVLACRFANGIFDITVTLDKDEKVAGFYFRQSAYSERELPDYADPSAYTEQDITVGKEPYYLPAKLMVPNGLESYPLVIILQGSGTLDIDGTLGPNKPYRDIAVGLASKGIATLRYPKKYLVYPDKMDEIGTTAEAEYVDDALVVIEQMKSIPQFSGIYLVGHSMGGMVAPWIAEEAGVDGVVVLAGSPVKLAQISLDQNLDLAGDQMTEEQKAQTIEFFTQLLNGEIPEETELSPGLTAAYYYSLDRYFCMPVLEKTELPVLIANAELDFQSPKHYFDIFVEELGDRPNVTLELLEGLNHLFMETNGKIKSVEEYNRPGYVSAELIDLIVEWIKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z3</accession>
    <name>I2F1Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730109.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0212"/>
    <dbReference type="EnsemblBacteria" id="AFK05946">
        <property type="protein sequence ID" value="AFK05946"/>
        <property type="gene ID" value="Theba_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0212"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_2_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657737" evidence="1">
        <location>
            <begin position="21"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="85"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="613" mass="68382" checksum="45913C8E02AC5463" modified="2012-07-11" version="1" precursor="true">MRKILLVTLTVLFFSLVAFASDPETFVNLTIGEPETLDPLHSYDTASGEVILNLYDNLIQYDGESVTDYLPMISTEVPSVENGLINPEGTVYTFPIREGVKFHTGNVLTPEDVKYSFHRYILGDPSGGPQWMIIEALTGGAHASVESWFEAYSGMPYSEAVDADKNVVSEEARQKLISFYEEVVSPKVKIEGNSVVFTLDAPWGPFMNTIAHFGSWAAITDSKWGIENGAWDGKADGWWKWHDLEPQESPYHNAEAGSGPFKLVEWDSAEQKVILERFDDYWAGPATIKNVMIWGIDEFSTRKAIFEAGDADIAYFGSSYLDQAEALAAEGKAVVTKGYPTASITSLHFNWLVAEGSEYLGSGKLDGNGVPRDFFSDIHVRRGFAYCYDGTTFVDEVLNGNGVLVPTDLPKGFLGYDETLPLPEFNLAKAAEEFKKAWGGEVWEKGFKIQLLYNTGNDERQTIAEMLAYFVNSINPKFKVETLGVQWPTYLAAQRNGFLPIFTIGWLADYPDPHNFIATYYASYGAYASRQGVPFQEWAAANVDAEISAAAVSVDNEERIKLYRSIQEKVIDAAIGIPLYMPTGLNVRAPWVEGWYPHLVRSGFYYYQLSKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F205</accession>
    <name>I2F205_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730120.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0224"/>
    <dbReference type="EnsemblBacteria" id="AFK05958">
        <property type="protein sequence ID" value="AFK05958"/>
        <property type="gene ID" value="Theba_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0224"/>
    <dbReference type="HOGENOM" id="CLU_796465_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="38380" checksum="7A013FEA11D082BF" modified="2012-07-11" version="1" precursor="true">MKMFRYFAFVVLMAILLSGCYIKPYEENGVETKFADDDIVFILRSKADAIELLIDEKIDFSTVVVPDGYLKIVKYVNEKTLIALAKGSEINRGEEILRIEGLEEENLITLIKIWDIDDIYYESNGTDPKLLGDFTGDGQVEGFDFIPFAQSYGNALGAPGYEAIYDMSSLENPASKAFSGIWGKIFSQEGVSDGKIDGPDFIVFANNYGYANPYLGTWTFTGTIDYNSSSFGQVDATGNGTATIESLNYNFTGNVTMSFEADYEDESGNPLHSEMTTTINNVSFDFDNLVMAIDATVDDFTGSGNTYDVRLRGALKTVGDAVYAQVPSGDIYLLNPERRIGTWSGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F231</accession>
    <name>I2F231_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730144.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0250"/>
    <dbReference type="EnsemblBacteria" id="AFK05984">
        <property type="protein sequence ID" value="AFK05984"/>
        <property type="gene ID" value="Theba_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0250"/>
    <dbReference type="HOGENOM" id="CLU_591621_0_0_0"/>
    <dbReference type="OrthoDB" id="2202576at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="459" mass="51580" checksum="7157A6095132BD78" modified="2012-07-11" version="1" precursor="true">MSKCCLSLLMLIIPLMILGSTGLHVTLSPSLSLDNIPSVASNYVPDLEDLDRYMRIPAIFSGGMEIAIGNSKLYVNMDLRQEFSDYLMGDWLSNLPLSTTSFLPAIDVNFPRLGYFERRDSNSFISLGRRKLGLGVSTYSFVISNFLPYFDHLWIELNGQAKSGEYLYDFFAVSADRTISGGPKTLLGHRFGYMNENLKVTFGEENLVYGVYPDLQDLGPFLIYHHTYQSNSNVTATLAAEVKLSDAMAYGEFTLDDFRLTSESSNSNPTAFGWVAGFLWRISDGRPYTGPKLDESEHEIRDKTLLQDGGLRVRMEHYHSTTYLYNRGTNIGKFTYPYRFNVLHLDSWPVITGFYGFPYGPDSTLTLIGIEYESQNVSLKIAAELLRAGSVTIDSPYSPPFDPEWYGPKKPITTSFILTGEGFYAANQNTTLFVAGKLTFSRKVDFGINVGFIRMFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F242</accession>
    <name>I2F242_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotransacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730153.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0262"/>
    <dbReference type="EnsemblBacteria" id="AFK05995">
        <property type="protein sequence ID" value="AFK05995"/>
        <property type="gene ID" value="Theba_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0262"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056531_0_0_0"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="3">
        <location>
            <begin position="77"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="298" mass="31046" checksum="D0C227D8A19E9301" modified="2012-07-11" version="1">MKDFSELVSLAKAGGTRRVVLIGSEDREGIRALKHAFDEGIATPVFVGREVETLEILKEEGLEGELIPASSPEEACEKGIKLVSSGKADVVMKGLLKTSILLKAVLNKEWGLRSGRVLSHIAAMDVPVVDRVVFVTDGGMIIRPDLQTKVSIIENAVAFLKSIGYEKPKVALIAAVEVVNEDMQETIDAAVISKMSQRGQISDCVIDGPLGMDNALSLAAAQIKKISGPVAGQADLLVVPDIASGNFVGKSAVYLAGGTIAGLILGATAPIVIVSRADSAASKLASIALASYSIGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F264</accession>
    <name>I2F264_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">Theba_0285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491753.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0285"/>
    <dbReference type="EnsemblBacteria" id="AFK06017">
        <property type="protein sequence ID" value="AFK06017"/>
        <property type="gene ID" value="Theba_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0285"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_3_0_0"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="8436" checksum="85BEE94D714C5F1E" modified="2012-07-11" version="1">MKEVLEHILKGIVREPDRITVTEAVDENGNMVFEISAAEEDVGQIIGKDGRTIKSINVLLNALAGSSKESFILKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A0</accession>
    <name>I2F2A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730195.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0324"/>
    <dbReference type="EnsemblBacteria" id="AFK06053">
        <property type="protein sequence ID" value="AFK06053"/>
        <property type="gene ID" value="Theba_0324"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0324"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658256" evidence="1">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="574" mass="65097" checksum="5D10FEEE9C54714C" modified="2012-07-11" version="1" precursor="true">MKKLSVLLVVLIAAGFLFAATEYHVEETWNGKPGGTFYYWGLGDPKTFNYDWAQETSSTDPLGFILATLIESDEGGMPTLPGLAKKWWFSEDGLTFFVQIREGLQWSDGEPFTIDDVYWTFVDVSFIPENTANGNGSYLDSNDQLPVVEIVDDTTISFTWTVPMVTALRQIGFRPIMPKHVLEEVVANGTYPEFWTIADFDKLVGMGPFVITDYIEGVRIVFERNPYYWKVDGNGVKLPYFDKLNYELLADQNTSLLRFEAGELDLYGPTAEQFPRLAEMAAEKGWITGVGGPALGSQFVTFNFNATDPVKREWFRNDGFRRAFVYAMDRDAIIESLYNGLGSPLYGPVSPSSGFYNPEIEKFAYKYSITRARLELKRGGFDWLADGTCVDANGNPVEFELLTNAGNVVREAISNIIVDGAAKLGIKVNFRPIDFNTVVSRLTDATYEAVVIGLTGSVDPGTGWNVYRLDGGLHFWNYPPDYNPDDHITEDMYILPDWEKRVDEIYRLQTSAVDDQDRYDLFAEFQMIFAEYQPVVFTMAQNFLYVYKNNIKMPVEKLTPATGLLYQLEGWWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B9</accession>
    <name>I2F2B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730211.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0343"/>
    <dbReference type="EnsemblBacteria" id="AFK06072">
        <property type="protein sequence ID" value="AFK06072"/>
        <property type="gene ID" value="Theba_0343"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0343"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_1_0"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="155" mass="18161" checksum="75EDE90DA06C98B0" modified="2012-07-11" version="1">MRNDQLKAELKKRNQRMTAQRELILRLFLEAGTEHLSADEIYHKVQGKNFRISKATVYRTIELLADIRLLRKIVFEDGVVRYELVEKGEHHHHHVICSNCGAVVEFHLDNLEELEELVKSRTGYTIEDHQLKFYGLCPKCQNAMKDKKSTSNEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E1</accession>
    <name>I2F2E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="8" type="ORF">Theba_0365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730223.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0365"/>
    <dbReference type="EnsemblBacteria" id="AFK06094">
        <property type="protein sequence ID" value="AFK06094"/>
        <property type="gene ID" value="Theba_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0365"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061534_1_0_0"/>
    <dbReference type="OrthoDB" id="1872374at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="217" mass="23664" checksum="A56ECF2D85D3E71D" modified="2012-07-11" version="1">MDSRKIPKPTIKRLAIFHRCLENLVISGVSSISSKDFADRLGIKASQVRKDLSYFGEFGKRGVGYNTELLLDSISEILGIRKRWNTCIVGMGNLGMALANYPGLSKSGFVAKALFDNNPNKIGMPMPNNLMIESTAKLKEIVKSRNVEIGVITVPASAAQSTADLLTEAGIKGIVNFAPIRLSLPQEIINEEIDISASFRSLAFSMTYGSSKKGRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E2</accession>
    <name>I2F2E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491950.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0366"/>
    <dbReference type="EnsemblBacteria" id="AFK06095">
        <property type="protein sequence ID" value="AFK06095"/>
        <property type="gene ID" value="Theba_0366"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0366"/>
    <dbReference type="HOGENOM" id="CLU_2155334_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="111" mass="12682" checksum="88887593AB067797" modified="2012-07-11" version="1" precursor="true">MEKRVVLKSQFVLVLMLIISLFLFVETLYIIRYVKESRSAEFEVIFYDNTTPIRILLDDEGYVLQPGESLMLSIGRNDEVIVEQEVAGRYTVRGGGKIVNVSIPRVKVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F3</accession>
    <name>I2F2F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0378"/>
    <dbReference type="EnsemblBacteria" id="AFK06106">
        <property type="protein sequence ID" value="AFK06106"/>
        <property type="gene ID" value="Theba_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0378"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="205"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="491" mass="56491" checksum="AD09E3EAADC9D4B9" modified="2012-07-11" version="1">MRKPRDRKSWSEYEIVSRLRSRERFVKEIRGFGDVKVAIIYPNSYKVGSASLSTHVLMTKFNELGSIRAERFFFHEGFSKYYSFDSLTPLDEFVIWSFSVHFELDLLNVFEILNKFSIPLRKEKRNRFHPLILIGGALTYFNDSLVSEIADVVYRGDLGEKFLEQLSAIDHRMSKEEMVSTLETEHQETIFSNCLGESAFISPDSVFGDRYLIEIGRGCFRKCKFCVAGYKFGRPRFRELKDTIDLMDSVAGFTKRFGLIAATVTDYPDIDEIAEHCIEKGYELSVSSLRLDSLSDTLMRSLKLSGQSFFTIAPEGGSQKIRNAFAKGISEEDITEALELGRNNDFHRVKMYYIYGAVFETQDDRTEISKTVHQALKMGYSSVVLSLNPLIPKPGTPFENMPMESVGVLRKLEREIRSELMMEGVKLDFESLKESRLQFALASIDREKGRELLELVERGIDPTPILNKYAEDVNSERKEWKEHGKEEYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J2</accession>
    <name>I2F2J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730260.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0417"/>
    <dbReference type="EnsemblBacteria" id="AFK06145">
        <property type="protein sequence ID" value="AFK06145"/>
        <property type="gene ID" value="Theba_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0417"/>
    <dbReference type="HOGENOM" id="CLU_959108_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="32157" checksum="274C3096A5DF8B40" modified="2012-07-11" version="1" precursor="true">MEENKPLRSLYLSMVIVFIALPHSEITFANSQIMEEFYYVTPEASVSGFTGIIVGTENNYDLLIIANGHLKRYSLSGAEIPQYESTDSNSKKCLNLIRNTIGLEAIVHEVTTSEEASAYVWILLDGEVYLIQSIIVSSGLSKAVDGGEIELVPAEEYARERSLGIWAEESEVLESAVEGIPETEEVQEVVEEDSRGAARLTISKIDIFDNGEHALLTLAADKGGYLEGSEVSILSRADRTTDEDVFSLDSQEPIETAEELRILITLDRSRTTSFEYDFFGKVIWIPEAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K2</accession>
    <name>I2F2K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-1,6-bisphosphate aldolase, class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730270.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0427"/>
    <dbReference type="EnsemblBacteria" id="AFK06155">
        <property type="protein sequence ID" value="AFK06155"/>
        <property type="gene ID" value="Theba_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0427"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_0"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="314" mass="34275" checksum="C0F17CB7CD987C5D" modified="2012-07-11" version="1">MPYVNTKEILERANKEFYAVPALNINNLEFLQAIIDAGVEEHSPVIIETSEGAIKYAGNGDIKLGAKLFVSMVESYARNVDIPVSLHVDHGKNFKIIMAAIQAGYSSVMIDASEFPFEKNVAETKKIVEIAHSLGVSVEAELGRLVGIEDNVAVESHEAALVDPDEAKLFAEETGVDFLAPAIGTSHGAFKFKGEARLDFARLKKVKDLTGLPLVLHGASSVPEDIKKLAETYGADFKGAKGVPGEILAESVKFGINKVNTDTDLRMAFIASLREFLSKNPGEFDPRKYFKTPKELVKNVIRERLRLLGCSNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T0</accession>
    <name>I2F2T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730340.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0507"/>
    <dbReference type="EnsemblBacteria" id="AFK06233">
        <property type="protein sequence ID" value="AFK06233"/>
        <property type="gene ID" value="Theba_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0507"/>
    <dbReference type="eggNOG" id="COG3877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2093953_0_0_0"/>
    <dbReference type="OrthoDB" id="1943427at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018658">
        <property type="entry name" value="DUF2089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09862">
        <property type="entry name" value="DUF2089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="13226" checksum="A722E5A3E5B6D284" modified="2012-07-11" version="1">MKKRLDKCPSCGTDLQITEYAYQNCKAKIIGSFSQGELSSLPEELLAFLKAFIKNRRNLSEFRKELNIPYSTARSKTGITGNRSRIRSCQPSSSQSIQNNQEARRVELTMKRSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2U8</accession>
    <name>I2F2U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DRTGG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0528"/>
    <dbReference type="EnsemblBacteria" id="AFK06251">
        <property type="protein sequence ID" value="AFK06251"/>
        <property type="gene ID" value="Theba_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0528"/>
    <dbReference type="eggNOG" id="COG4109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140224_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="121" mass="13000" checksum="C6C676BE5245BA24" modified="2012-07-11" version="1">MMTLSRIIEILGCEILYCGDGDPEVESVGAADLMSDVLAFGGPGMILVTGLNSPQCVRTASVVGATAVVIIRKRNVPETTIELAKELDMPLVHARMSMYRACGILFNENLGDSLEEGKHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W3</accession>
    <name>I2F2W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492172.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0543"/>
    <dbReference type="EnsemblBacteria" id="AFK06266">
        <property type="protein sequence ID" value="AFK06266"/>
        <property type="gene ID" value="Theba_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0543"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="121" mass="13780" checksum="95FFB1F6405A76BA" modified="2012-07-11" version="1">MKRVLIVEDEKNLRLLIEEELTESGFEVKSTGTAEEALEILSTNNSFDLMTIDIEMKGMNGLELAGVVRKRFPNMKIVLLTAYTHYKHDLSSWAADAYVVKSPDFSELKKVIESLLREDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X5</accession>
    <name>I2F2X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0555"/>
    <dbReference type="EnsemblBacteria" id="AFK06278">
        <property type="protein sequence ID" value="AFK06278"/>
        <property type="gene ID" value="Theba_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0555"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="82"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="317" mass="33776" checksum="3C25BDEFA301FE86" modified="2012-07-11" version="1">MNQQRQSLTEMLGIKYPILQGGMAWISEHNLAAAVSNAGCLGIIAGGNLSPEDLLYEIRETRKLTSRPFGVNVMLLSPYAQEQIEIICRERVPVVTTGAGSPSSFIEKLKTAGTKVIPVVASSGLARRLERQGVDAVIAEGMEAGGHIGKVSTMVLVPAVVSATRIPVIAAGGIADGRGLAASLALGASGVQMGTRFICTTECRAHSRYKERILLSNELDTVVTGNSNGHPVRGFRNRLTRHIEELEKQGSGFEEIEKIAVGALKRAVENGDINDGSMMAGQSCGLIGEILDVSQLVQSIIDEAEETIRFLGGIKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F335</accession>
    <name>I2F335_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial capsule synthesis protein PGA_cap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730416.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0620"/>
    <dbReference type="EnsemblBacteria" id="AFK06338">
        <property type="protein sequence ID" value="AFK06338"/>
        <property type="gene ID" value="Theba_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0620"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739275_0_0_0"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="71"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="374" mass="41428" checksum="5A46B8ADA91BCB9B" modified="2012-07-11" version="1" precursor="true">MSRKFAMGFALALFLMTHGLVFSFPVVCGDLGRFTFTDAIFYLRKLIFGTISRPYEENYQAELPDLACAITLTAFGDLMYSKGLVIAGDPYSSVEKSLFKSEIVFANLEFPIDTRFPESAFPKFNGSSEYFEKVVTPLGINVMNIANNHSLDRGNEGLRSTRTFLNDRGIHCVGFGEESRFSIIPFDKVRIAVSGFTFGTNGATVDSESSLNVANLNTFEDAETALSKIIPIVESMSEEASVIVLSLHWGLEFENKPTEMQVEVARKLCDEGVDLIIGHHPHVLQPLEVYLNARGSTSLIIYSLGNWISSMKAKDCRITASLKIELSEDGSVCGIKVFPYFFNLSKMQLVPLSNPALIPESFAYYLDSSPNCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F339</accession>
    <name>I2F339_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0624"/>
    <dbReference type="EnsemblBacteria" id="AFK06342">
        <property type="protein sequence ID" value="AFK06342"/>
        <property type="gene ID" value="Theba_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0624"/>
    <dbReference type="HOGENOM" id="CLU_3027037_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="55" mass="6028" checksum="F5EE781DA861E727" modified="2012-07-11" version="1">MNVFIVILAIFGGLVFLGLAVKLAFFGLRVIFGLAFVGLIVFAIIWLLSKVLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F386</accession>
    <name>I2F386_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsL</name>
        <name evidence="8" type="ORF">Theba_0672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492338.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0672"/>
    <dbReference type="EnsemblBacteria" id="AFK06389">
        <property type="protein sequence ID" value="AFK06389"/>
        <property type="gene ID" value="Theba_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0672"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_0"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="124" mass="13787" checksum="C94FC0E17D6D4952" modified="2012-07-11" version="1">MPTINQLIRHGRKQLKQKSASPALENNPQKRGVCVRVSTMTPKKPNSALRKIARVRLSNGTEVTAYIPGEGHNLQEHSVVLVRGGRVKDLPGVRYKIVRGTLDAEGVANRKQSRSRYGAKRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F391</accession>
    <name>I2F391_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">Theba_0677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730463.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0677"/>
    <dbReference type="EnsemblBacteria" id="AFK06394">
        <property type="protein sequence ID" value="AFK06394"/>
        <property type="gene ID" value="Theba_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0677"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_0"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="210" mass="22775" checksum="E3F89C05A557179F" modified="2012-07-11" version="1">MKGILGRKLGMTTIYKDGKAFGVTVVKAGPCTVVQKKTSDGGEYDAIQVGFEELTPERAKKVLTKPLVKKFEAAKVKPHRILKEFKVGNINDFNVGDIIEARVFSEGEKVDVTGFSKGRGFSGAMKRWNFRGGEASHGSKFHRELGSVGNHTEPAKIWKGKKMPGQYGNEKKTVKNLTVVKVDAENGLLAIYGAVPGARGGLLVIKSANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B7</accession>
    <name>I2F3B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="9" type="ORF">Theba_0703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492374.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0703"/>
    <dbReference type="EnsemblBacteria" id="AFK06420">
        <property type="protein sequence ID" value="AFK06420"/>
        <property type="gene ID" value="Theba_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0703"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_0"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="128" mass="13736" checksum="CE9B31EE2188723F" modified="2012-07-11" version="1">MAKRPAAKKKRKLTTDRGVVHIKSSFNNTIITLTDPEGNTLMWTSGGTAGYSGSKKSTPYAAQLGADKIAKEAIKLGITRVGIEVKGPGSGREAAIRTIQAAGLTVETLKDITPLPHNGCRPRRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C3</accession>
    <name>I2F3C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0709"/>
    <dbReference type="EnsemblBacteria" id="AFK06426">
        <property type="protein sequence ID" value="AFK06426"/>
        <property type="gene ID" value="Theba_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0709"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="33123" checksum="FDABA15396EE89C5" modified="2012-07-11" version="1">MVRRVIGIDLGGTETKIGIVEEDGKIVEKKVIPTRVSEGRTTVVTRIGEAINELLVQSGIDSKQIIGIGVGSPGSIDHDTGTVLFSPNLPDWSGFGLAAMLERVTGIRTFVENDANSFILGEWAFGEFKGSQHMVGLTLGTGVGGGVITHGILMTGSKGYGGELGHTIVEPEGPVCGCGSHGCLEALASATAIINLAREYSKRFPQSTIFASPEINAKVVFDAAREGDLAATLIVERATRALAIAIGNFIHVFNPEHIVIGGGISRAGDLLINGIREKLPAFVMTSFNGTFSITLSKLVENAGITGAASIVFYRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D4</accession>
    <name>I2F3D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Theba_0720</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730495.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0720"/>
    <dbReference type="EnsemblBacteria" id="AFK06437">
        <property type="protein sequence ID" value="AFK06437"/>
        <property type="gene ID" value="Theba_0720"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0720"/>
    <dbReference type="eggNOG" id="COG1355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_0"/>
    <dbReference type="OrthoDB" id="1070303at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="30555" checksum="1BC39DFED8CC2564" modified="2012-07-11" version="1">MIRRPVVSGKFYADNEEELKSQIRNCFFHPVGPGSLPHGWEKNEGPIGLIVPHAGYMASGPVAAWSYWRAGALVKPSTVLIVGPNHTGLGTKLSLWLEGAWETPLGSVEIDHEFGRSLMAESNGMIMPDTSAHLYEHSIEVQLPFLQFLYSDFKIVPLIMTDQRVEVALSLSEIIKKELSRRNDVLVIASSDLNHYEAHEVTMEKDNELLSLILDGKYRESYELSQEKRITACGLGPIVAVRNSFESMEVLCSTTSGEVMGDRYRTVGYVAALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G0</accession>
    <name>I2F3G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop ATPase, MinD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730517.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0748"/>
    <dbReference type="EnsemblBacteria" id="AFK06463">
        <property type="protein sequence ID" value="AFK06463"/>
        <property type="gene ID" value="Theba_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0748"/>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067767_1_0_0"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="291" mass="30994" checksum="B0403BE93319B5B0" modified="2012-07-11" version="1" precursor="true">MFQIAIVSGKGGTGKTTLSGSLSVLFDSIVMADCDVDAPNLHLILENKLIEKYEYFGGKKAEISDSCISCGICEKYCRFDAVIRGGPYSVDPYACEGCGMCVAVCPADAITLKDNKSGDYFLSQSNGIPLVHALLTPGEETSGGLVAEVRKLAIKVAEEEKKEVIIIDGAPGIGCPATSSITGTTYVLVVAEPTVSGNHDLARIVETIKHFKRDFGIVINKWDLNKSKSSFIESWCGANGIEIIGKIPFDEQVERATIMGKPVVSIKGSKAAEAIVRIAQRLKRKISGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M4</accession>
    <name>I2F3M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">Theba_0813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492511.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0813"/>
    <dbReference type="EnsemblBacteria" id="AFK06527">
        <property type="protein sequence ID" value="AFK06527"/>
        <property type="gene ID" value="Theba_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0813"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_0"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="603" mass="67493" checksum="904B1A940640ABFC" modified="2012-07-11" version="1">MYKRDRIRNISIIAHIDHGKTTLVDRFLDITDTVDRRNKKDQFMDSMDIERERGITIKSKPVKLNYLADDGITYEINIIDTPGHVDFNYEVSRSLAACEGAILLVDASQGVEAQTVGNTYLAIENDLELIPVLNKIDIPNANIEETLAEIVDLIGYSPEDCLQASAKTGQGVKEILEAVVKRVSPPSGMLEAPLKALIFDAIYDKYRGVVIHVRIFEGSVKAGDRIQMMASGEIFEVVEVGYFLPQMEITDSLDAGEVGYIIAVIKDVSSAKIGDTVTSANNPTDTALPGYKEAKPMVYAGMFPGMPEYYDELRKALDKFKLNDASLVFEPENSPALGFGFRVGFLGLLHMDVVRERLEREFEIACILTAPNVVYRVTLQNGEVAEITNPASFPEPGEFLRVEEPFVDLSIITPSEYMGNLIGFITSEKRGDFKAVENAGKNRVVLRFEAPLSEIMFDFFDRMKAISRGYASMDYEILGYRESDLVKVTILVNKETVDSLSFIVHVDKEYSVAKKVVDKLSELIPQHQFQIPIQAKSRGRIIARSDIKALRKDVLAKCYGGDVTRKMKLLEKQKEGKKRMREIGQVTIPQNAFLAILRIGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3P4</accession>
    <name>I2F3P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730588.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0833"/>
    <dbReference type="EnsemblBacteria" id="AFK06547">
        <property type="protein sequence ID" value="AFK06547"/>
        <property type="gene ID" value="Theba_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0833"/>
    <dbReference type="eggNOG" id="COG2871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_7_2_0"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="366" mass="40811" checksum="94D2ACCCBCA8891D" modified="2012-07-11" version="1" precursor="true">MQIVISALVIGGISALLAAILTIADALVNNYGEVSIRVNDSKDLKVKGGATLLSTLASEKIFIPSACGGKGSCGLCRVKVLTDVGPILPTELPYLSEKEKKNNIRLSCQIKVKSDISIEIPEELFNIMEYIASVSSITDVTHDIKEVFFDLEDEIEFKAGQYVQLIVPAYGDIKGETMRAYSMSSQPSVKSGVELLIRLVPNGIVTTYVHKMLKVGERIRILGPFGDFYLRDTDSDIIFIAGGSGMAPIKSIIFDMMEREVKRNAYYFFGARSKRDLFYLEEMKEVERKMPNFHFIPALSDPLPEDNWEGETGLITDVVDRYLSEQGDEIDREAYLCGSPGMINACIRVLTRHKVLEEKIFYDKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q4</accession>
    <name>I2F3Q4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730598.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0843"/>
    <dbReference type="EnsemblBacteria" id="AFK06557">
        <property type="protein sequence ID" value="AFK06557"/>
        <property type="gene ID" value="Theba_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0843"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_2_2_0"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="379" mass="44141" checksum="65157C9BDF474A94" modified="2012-07-11" version="1">MGMGLYIHIPFCARRCSYCDFCTVEYDGNLVRQYHDLLKKEVEMYPASERVETLYFGGGSPSLYPVELLRDLMSFISCSFDAAPVEVTIEANPWELNLKNLKQWRDIGFNRLSIGIQSSEREILERCDRPVPKNLRDRLMASRDIFENLNLDFILGLPGENESNVAGNLEMISAINPDHVSYYVFDSDHETKLMRLVHDDIIDLPRQEIVEGLHDIILDSLSKMGFSRYEISSWERGRRECLHNLKYWRNEQYMGFGVSAGSHFDRKRYVNTSDLLEYRYLVNLRRRPVFELRENSVIQEVFETLFMGLRLMEGVDLSKLELPDELNNTLVSELRAHLGDYLSPDNSRIRLNDNGMDFSRSVLEKLIDIKEEMVIAFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q5</accession>
    <name>I2F3Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730599.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0844"/>
    <dbReference type="EnsemblBacteria" id="AFK06558">
        <property type="protein sequence ID" value="AFK06558"/>
        <property type="gene ID" value="Theba_0844"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0844"/>
    <dbReference type="eggNOG" id="ENOG5033YMM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003933_0_0_0"/>
    <dbReference type="OrthoDB" id="2048759at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="30085" checksum="E2E5E7CDF89873F8" modified="2012-07-11" version="1" precursor="true">MKRVLCLSLVLLSGILLLSETQLKLNNAGWSVSADIRAYEDIYLTLALATGIPYVGVTYVDSWEEYSTGFLKLKIQDGVFRGSLLASHEGLFMGVRYVSNTNQIPIFSHTALELELSTVSKMKYLVRNWVRLPLGQLNGGLSVFLHGEDSFSFNDVGLYLYAKEYERSLRIRNMESNVVATVDLKTNDSLGEVGYGIGIGMNYLSFDPGLAFAGSFIVPAGDLRLMLSPTVMVSMRGIDAQILISKLGSDDSIFAGISVTNFNLNGIFMRLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Q6</accession>
    <name>I2F3Q6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ORF">Theba_0845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730600.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0845"/>
    <dbReference type="EnsemblBacteria" id="AFK06559">
        <property type="protein sequence ID" value="AFK06559"/>
        <property type="gene ID" value="Theba_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0845"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_0"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="331"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="480" mass="54165" checksum="55247D4E848D27A7" modified="2012-07-11" version="1" precursor="true">MLRTVIGLEIHAQLKTETKAFCSCRADVFDLEPNTAICPVCTGQPGTLPVLNKKVVEFAVLAGIAMNCTINKRSVFDRKNYFYPDLPKGYQITQYFFPIAEHGYLYLENEEEKRKVRIRRIHIEEDAGKMVHQGTDSITGSSGSFVDLNRCGVPLIEIVTEPDLRSPAEARIFMELLRDTLRALEVCSGDMEKGALRCDANISMVDETGRSSNRVEVKNINSFKFVEKALEFEQERISKALASGEDVAKETRSWSFSSKETFSMRSKEEENDYRYFPEPDLPVLVVSDEVIERIKGNLPELPWEKIDRFVEQYSLPRYDASVLSSDGDIASYFEEVAQVTGKPKESSNWIMGEVLRLMNDKGLTIEEVKVSPEHFKELFDLMDKGKISNKIAKDIFPTVVEEKKSPKEIVKEKGLEQIDDAEVIEDALQKAMANNPAAVKQFREGKEGVLGYFVGAVMKATRGKANPSKVNEIARRVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U1</accession>
    <name>I2F3U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">Theba_0884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730632.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0884"/>
    <dbReference type="EnsemblBacteria" id="AFK06594">
        <property type="protein sequence ID" value="AFK06594"/>
        <property type="gene ID" value="Theba_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0884"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_0"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="114"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="29591" checksum="30C0DE7B26E1E848" modified="2012-07-11" version="1">MILDGKIVSKSIYDEIKEKIGNRTGELPSLVLFCDEPDPSNKTYMKSIRKQGEKLGIEVIVRDSGSNPVEEISELNKDKSVAGIMVMHPLKNANEKAVLAALDPGKDLEGRTVSNLGGIINDEEFFAPPTAEAVMEILDYYGIEVKGRDITIVGRSNTVGKPLALLLLKKGVDGTVTVCHSRSRDISEKTFNADIVVSAVGIAKFIEREMIRPGAVVIDVGINFVDGKLVGDVDFDEVSQIAAAITPVPGGVGSVTTALLFRHYYRSIERMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U9</accession>
    <name>I2F3U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492598.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0892"/>
    <dbReference type="EnsemblBacteria" id="AFK06602">
        <property type="protein sequence ID" value="AFK06602"/>
        <property type="gene ID" value="Theba_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0892"/>
    <dbReference type="eggNOG" id="COG2052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165326_2_0_0"/>
    <dbReference type="OrthoDB" id="1786332at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="79" mass="8941" checksum="CAEB987B57FB5A2F" modified="2012-07-11" version="1">MDRVVNVGFESFVVKDRILAVLPVESSAVRRLKQLGMETGKIVNLTFGKRTKAILITNSGHVIFSFLPPKRIIEKLFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V4</accession>
    <name>I2F3V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730639.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0897"/>
    <dbReference type="EnsemblBacteria" id="AFK06607">
        <property type="protein sequence ID" value="AFK06607"/>
        <property type="gene ID" value="Theba_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0897"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="257" mass="28326" checksum="428ADB784A69C452" modified="2012-07-11" version="1">MSLLKLEQVTKRFGGLTAVSDFNLDLQEGELVGLIGPNGAGKTTVFNLITNTYYLSEGKILFEGKDITGLKTDRIAAAGIVRTFQNIRLFGELTVLENVLTACHLRLRSSVFSAVFGFPGYMREELAMREKARSLLKTLGLEKYERDQAGSLPYGLQRKLEIARALATQPKVLLLDEPAAGMNPEETLALGALILKIRKEFQLTILLIEHDMSLVMTICERIIVLDHGVTIAEGLPEEIQNNPDVITAYLGTGDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F401</accession>
    <name>I2F401_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730675.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0948"/>
    <dbReference type="EnsemblBacteria" id="AFK06654">
        <property type="protein sequence ID" value="AFK06654"/>
        <property type="gene ID" value="Theba_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0948"/>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096350_0_1_0"/>
    <dbReference type="OrthoDB" id="1918210at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="133" mass="14152" checksum="31CDCF7A0786D959" modified="2012-07-11" version="1" precursor="true">MKGRTLIKVLVTVGILIAALLIIMFAFVVPKLEAGLKELDTLEFAPLNLSELDDGYYEGSFGAGIVSATVRVAVSGHEIKSIEIVKHNNGRGKPAEAITASVIENQSVEVDVISGATYSSKVILKAIENALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F419</accession>
    <name>I2F419_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730693.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0966"/>
    <dbReference type="EnsemblBacteria" id="AFK06672">
        <property type="protein sequence ID" value="AFK06672"/>
        <property type="gene ID" value="Theba_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0966"/>
    <dbReference type="HOGENOM" id="CLU_1720165_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="152" mass="16443" checksum="1B3834AF88A7C70B" modified="2012-07-11" version="1" precursor="true">MKKLLLILVVFGIAVAVFSEPLLVWPDKTHGKPLVAGLYSPVYGEAKLDVFGNITGWTGPNLGLGWTWKTYFSPLELQKVNFYYEFGTNVVIFPYIGVGFDYALVLQNNQTLLVGAGASASPFTVLGFFFEGPAAILSSVLSSVILSVAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F426</accession>
    <name>I2F426_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492703.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0973"/>
    <dbReference type="EnsemblBacteria" id="AFK06679">
        <property type="protein sequence ID" value="AFK06679"/>
        <property type="gene ID" value="Theba_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0973"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2807463_0_0_0"/>
    <dbReference type="OrthoDB" id="2009179at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="67" mass="7983" checksum="5F5B7E4CD66C4A87" modified="2012-07-11" version="1">MEDGYCINYHECPVVRAYENGKINREWIEMYCEKDWTECARFRLDDLLSVSTDFVLPDGSIEERLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F449</accession>
    <name>I2F449_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492734.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0996"/>
    <dbReference type="EnsemblBacteria" id="AFK06702">
        <property type="protein sequence ID" value="AFK06702"/>
        <property type="gene ID" value="Theba_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0996"/>
    <dbReference type="HOGENOM" id="CLU_2789086_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="68" mass="7987" checksum="934214657158246F" modified="2012-07-11" version="1">MDALERIEIRYGKVFDFLQSMYRLTNEERLTKRFSELSPGYAPVGKIDEWVKSSRANQRTGIILSIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F455</accession>
    <name>I2F455_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730719.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1003"/>
    <dbReference type="EnsemblBacteria" id="AFK06708">
        <property type="protein sequence ID" value="AFK06708"/>
        <property type="gene ID" value="Theba_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1003"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_0_0"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="159"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="504" mass="57676" checksum="B09DC2D7484E872E" modified="2012-07-11" version="1">MRVLMVYPEYPETFWSFKHALKFVSKKAAYPPLGLMTVAAMLPKEWEKKLIDMNTDTLRDEDIEKSDYVMISSMDIQFDSTKNVIQKCKDLGVKTVAGGPLFTTRPEEFSEVDHLVLGEAEKTLEPFLLDLEKGQAKHIYKSDDFPDIESSPIPDWSLLDMRKYSSMNIQYSRGCPYNCEFCDIVLLNGHIPRTKSAEKLVAEMEALYKVGWRGGVFLVDDNFIGNKVKLKREILPAIAEWMKKRNYPFVLNTEASIDLSDDDELMRLMVDASFGTVFVGIETTEEESLVECGKFQNRNRDLLSSVRKMQEFGLQVQGGFIVGFDHDKPSVFSNMIDFIQKSGIVTAMVGVLTAPTGTRLFQRLKKENRIVSEFSGNNTSIMTNIVPKMGMKNLVDGYYRILKSIYAPKPYTQRVITFLKNYKPNSVKHVRPFTDSIKAFLKSLWVLGIKDKGRMNYWSLLLWTIFFKPSLFPLSVEFAIYGYHFRKSLSFGLQAENEAQPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F476</accession>
    <name>I2F476_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730739.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1024"/>
    <dbReference type="EnsemblBacteria" id="AFK06729">
        <property type="protein sequence ID" value="AFK06729"/>
        <property type="gene ID" value="Theba_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1024"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_2_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="341" mass="36348" checksum="EAFBECBD2D624CC6" modified="2012-07-11" version="1" precursor="true">MSNSDVSFEGRKTLTRKRTSILKSQWFYLLVAEIVIAVITGLVNPRFFSTSNIMNVLEQIAVLGVVSSGMTLLIISGEIDISVGANIGLSSVVMAMIIKAGQPYLIAIIAGIALAVFNSLLVGITARAFKAPSFITSLAFISVFQGVALAITKGTFQTIYGKFEFIGTYRLWEIVPLSFLISIAAYIVMHFLLSYTKLGRRTYAVGSNPSAAYLSGISVNKAKLSAFALNGLFIGVAAMVLLSRIGAAQPSTGTGIELKAIGAVVIGGTPLAGGKGRIIGTFFGVLLMGIISNSLNMLRVNPYFQTVTFGLLIIASLAVSVLSSYRKKEKIKPHSSKEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F478</accession>
    <name>I2F478_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730741.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1026"/>
    <dbReference type="EnsemblBacteria" id="AFK06731">
        <property type="protein sequence ID" value="AFK06731"/>
        <property type="gene ID" value="Theba_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1026"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962449_0_0_0"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="50"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="289" mass="32198" checksum="39B82D3AE18EB242" modified="2012-07-11" version="1">MKIGFHTDAFNSAVFSFEKALQWAQKNDVHYIEPGIIDGVSWIHGLGYFPHISLSEDPLKTKLKLQEYGVRFSQIDSAFPLSGNEGFYNGVPYVLKSIPWAKLAGCENIATTDGLKKPLGFSEDEALELMKRAYRIIVETAELYEININIEVHGYFTTNPDLLDKMLNFVQSDRLGLNLDTGNSFIAGQDPVAFCGRFIDKIKHVHIKDVSKDLADAMRGKDTGIGISHSAIGDGVNADNIKTIIAMLRDYGYNGTLSMECEGMGGPLIERSLQWLRKTLEELGIEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F498</accession>
    <name>I2F498_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730757.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06751">
        <property type="protein sequence ID" value="AFK06751"/>
        <property type="gene ID" value="Theba_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1046"/>
    <dbReference type="HOGENOM" id="CLU_2093954_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="13356" checksum="E4708AD9CE49BA43" modified="2012-07-11" version="1" precursor="true">MTPPNVILTMLLVRIPVPREKGTPFFTKEREQEREEERKREKGREEREKKRLKTREKSRLLVSEANSRTYALSALVSVQRSAKSGSLKSGSLMKDPVQEHYEMTEEEFVGADSTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C2</accession>
    <name>I2F4C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730773.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1070"/>
    <dbReference type="EnsemblBacteria" id="AFK06775">
        <property type="protein sequence ID" value="AFK06775"/>
        <property type="gene ID" value="Theba_1070"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1070"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_0"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="112" mass="12606" checksum="07395694BD610E8B" modified="2012-07-11" version="1">MDCIFCKIASGEIKSSFVGENDWFVAFDDINPVAPTHVLVVPRKHVKSLEELAKYDTECMRSFFELVEQIVELKGIKTSGYRLIVNQGSDSGQEVEHLHFHILGGRKLGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I8</accession>
    <name>I2F4I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730832.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06841">
        <property type="protein sequence ID" value="AFK06841"/>
        <property type="gene ID" value="Theba_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1137"/>
    <dbReference type="eggNOG" id="ENOG5032SNM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090993_1_1_0"/>
    <dbReference type="OrthoDB" id="1866297at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025591">
        <property type="entry name" value="RloB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13707">
        <property type="entry name" value="RloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="22581" checksum="9C293321871AA706" modified="2012-07-11" version="1">MKRKQRRSRKTKDTIVIVCGRTKTEVNYFKSFGLKIGRLGKVRVEVIGTGSNTAEPIALVKNAISLKDSDSSIAAVWAVFDKDNFDLGPAIDEARDSGVSVAWSNQAFEIWFILHFEFFTREINRAKYSEILEKHLGSKYEKNDRNLFDKTFAMIENAIENAKKGHQQHITFGHDPDSACSCTTVYKLVEELLKWIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K2</accession>
    <name>I2F4K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730845.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06855">
        <property type="protein sequence ID" value="AFK06855"/>
        <property type="gene ID" value="Theba_1156"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1156"/>
    <dbReference type="HOGENOM" id="CLU_378907_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="718" mass="82517" checksum="D90A5B13DBABDFD5" modified="2012-07-11" version="1">MDRETVKLTLLAEALEMSWNSYVVYGPLAELDAFLDKDAAVKLAEALKSGFMLEESVEKIMDDGFFRGYLAGMMLHNDSISLESKEAIARILEDNLLSLLKSADESLPSVDKFYGEPGDYDKRFFPFFEDKDKARSKSSLRENLSLFWYYSKDSYYIPLILWGNELASFLSKNAHKQELNGQAAEKLKKIMVTAEASYAMSDAVRSIVGFQVPKAESDTSSQLPMFSLIMNKNVSTEEIVELIKSITQYSVVNLMYAPVAMTRSDITEESERAREIVFRVFDSLENSILAFLLNGGDELTINGFLYQIVLQYDFAKLFDRLTSLLEMLTVEFADAALLAIASALIEKEETKENVERFIEYMKAFKDSFGLLTAGFLLSRKYELEDDSFSTEIRRDRKPDETDYYLLLELARGFLDDLEVAYQEMVGEYNHLGDLEDVFEELEEITEPCFVSADGSDEEVEYSRVPMYTLINAVIRNNDLDDAIEAIEAYCDRYIFNFEFVNTLLYMPSKSIDKVMQLLLFSGEMAVGFIDDIADQDDEAYLLSKEESPSNREYLDLIEKYIEKLIDDKKYREASRAIAAVDPFVDPEDVDNLFTSMIIVRWRTKDFENLKTMLEAIDEESDPRALIVKALMNYFNKEVDAAEGIIIDILQELPDFIQYLLENDEPDEEDFDRADDGDVRSQKKIDAKLLAEEFREDWFKLKGGKDWLKKVQKVFDEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q1</accession>
    <name>I2F4Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730891.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1207"/>
    <dbReference type="EnsemblBacteria" id="AFK06904">
        <property type="protein sequence ID" value="AFK06904"/>
        <property type="gene ID" value="Theba_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1207"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_1_1_0"/>
    <dbReference type="OrthoDB" id="1680141at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="117"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="281" mass="31345" checksum="7B101416A2C29653" modified="2012-07-11" version="1">MSSLIQSYNEALGLFTQTEEKIAGFIMTNPEAALELSVNDLASRLNVSPSMVVKASQKMGFTGYSQLKLAVASELNVLVQREKSTILIEDLDAYEDLVSSTIREAYSRLSEDDLKKAAELLVESENIDIYAFGFDAVAGHDLYLKMLQSGKRVKLIENGYEQMISAYNLKDDSVVVAISSTGTSIDLLDALKFSEKTGASVITITPVGSRLSTYSNVNLESYYSKLIFPEGGLITRVVQLMILDVLYLKFLQISGKNFEEKYSKFREVLDFKRRGTKKERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V4</accession>
    <name>I2F4V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nth</name>
        <name evidence="7" type="ORF">Theba_1269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730938.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1269"/>
    <dbReference type="EnsemblBacteria" id="AFK06957">
        <property type="protein sequence ID" value="AFK06957"/>
        <property type="gene ID" value="Theba_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1269"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_0"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="24713" checksum="95748544F93A8EB4" modified="2012-07-11" version="1">MSRNDCSPEAVSSWIVGNFPREQEYGDPFKVLVSTILSQRTRDENTEEASRRLFSVYPDPQSLIDAKPEDLYDLIKASGMYRQKAARIINCARMIVESFAGVVPDTLEELVTIPGVGRKTANIVLNVSFKKEALAVDTHVHRIANRLGWVKTKTPDDTEFALMKILPPSIWGPVNGSMVEFGREICRPIGPKCNLCGISQCCEYFSLVSEQTTERQKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z8</accession>
    <name>I2F4Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1313"/>
    <dbReference type="EnsemblBacteria" id="AFK07001">
        <property type="protein sequence ID" value="AFK07001"/>
        <property type="gene ID" value="Theba_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1313"/>
    <dbReference type="eggNOG" id="ENOG502ZS3S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545825_0_0_0"/>
    <dbReference type="OrthoDB" id="2205647at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="173" mass="19595" checksum="EBB3426ADD2B7F34" modified="2012-07-11" version="1" precursor="true">MIRNSEARSRGLTMTEMLVVMALSFIVVSVVLIVGNVAAREIRKINANMEVNEEISRFQLSLKQIVTRSWTGLGDIEVENTTIGMLTSVPYARKNEIYEQTPATVTFDQVRNEVVYSFHDQNNVVSTDVLAKGVLDCRFKYESVFLTYDATFSTYSEDMPVVIKNVKGAVRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F510</accession>
    <name>I2F510_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1325"/>
    <dbReference type="EnsemblBacteria" id="AFK07013">
        <property type="protein sequence ID" value="AFK07013"/>
        <property type="gene ID" value="Theba_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1325"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="394" mass="43043" checksum="0C0230E5E57D05E9" modified="2012-07-11" version="1">MSKPLEGISVLDLTRVLAGPFCTMLLCDMGANVVKVERPEGGDDSRSFSPFVGDDSAYFMSINRGKKSITLNLKTVEGKKLLERLIERFDVLVENFRPGVFERLGFSAQRLREINPRLIYTCSSGFGHSGPMSHRTAYDLIIQGLSGMMSITGPDENSPTKVGSSIADIFCGTFACIGILAALHSRNLTGKGQKVDVAMLDSMVSVLENAIARYAATGEPPVPIGNRHPSIAPFASFKTLDGIINIAVGNDVLWEKFCKAIGRPEMCDDPKFVNNPARVRNLEELMEILGGELEKRTSDEWLGVFGKLDIPSGKINNIADIFEDEQIRAREMIVEVPHRCGNVKMPGVPIKFSDTPASIAGPAPLLGEHNREVYAGMLGLSDLEMEELKRKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F545</accession>
    <name>I2F545_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-peptide hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acylaminoacyl-peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730994.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1360"/>
    <dbReference type="EnsemblBacteria" id="AFK07048">
        <property type="protein sequence ID" value="AFK07048"/>
        <property type="gene ID" value="Theba_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1360"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_3_2_0"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="7">
        <location>
            <begin position="386"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="597" mass="67626" checksum="21B48C3B714AF63E" modified="2012-07-11" version="1">MAEKKYTIEELMQNETIASFAVSADSRKILYSSDKTGNYNVFELDQEKGRHRQTTSLDENALVSFIFEDGSFIFAMDKGGDELHHLYLFSDEEIRDLTPFEKTKSGFHMSVGDKVYYYSNRIDKSRFDLYRFNEGDLTSELVFENKDLFELGPISSDERFIALRKLRTANDSDIYLYNFVNGDIKLLSPHQSEANFKPLFFSIDSLKLYYVSDSAGEFMTLWEMNIESRVSEEILDLEWDIIAGRMSEDGENAVLVLNRDGFSELHVIETKSNSLKMPPIKTSGVVYDQCFSKDGQLLYYLCDSATSSPNIFSINLETKKTKKLTDSMSRNVNSNDLSEASVLRFVSYDGLEVPGIFYPPKNVPAGEKAPAVVWVHGGPGGQSLPKYSPEIQFIANHGYAIYAVNNRGSSGYGKSFFRAADHKHGEADLDDCVEAARFLATLDFIDEERIAINGGSYGGFMVLAALAFRPKEFKAGIDLFGVSNWVRTLKEVPAWWKAIKDLLYTKIGNPFEEEEYLKSISPLFHAERIERPLLVLQGVNDPRVLKVESDEIVESLKKNGVPVEYVVFEDEGHGFKKKVNRIKGAKAMLAFLDKYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F554</accession>
    <name>I2F554_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731003.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1369"/>
    <dbReference type="EnsemblBacteria" id="AFK07057">
        <property type="protein sequence ID" value="AFK07057"/>
        <property type="gene ID" value="Theba_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1369"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_0"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="159" mass="18411" checksum="4B09D1C946CDA344" modified="2012-07-11" version="1">MSIYDFELTTIDGWNKSMEDFKGKVVLLVNTASKCGYTPQYEGLQQLYEEFKEKDFVVLGFPSNDFLRQEPGSDEEIKTFCSTNFNITFPMFSKIHVKGKNIHPLYEYLTSGGGKKEFSGKVKWNFTKFLIDRNGEIIGRFEPKEEPETFRSAIEEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F568</accession>
    <name>I2F568_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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        <property type="gene ID" value="Theba_1383"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_ARSR_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="269"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="363" mass="42175" checksum="E7EF218F75F3CFA4" modified="2012-07-11" version="1">MNWLNKVEVRSSTACDLLHGMFRLNNNDRFLELFASPQFKGKFEPYRNIQTWVTETRELLTSDIVEKLKEFFDWETFLGMCLLPDITHSNLESASQLIEFVQEMPERVLLIHFIYSGYGPRMGTIDMDAFDKIMKNDRDMLLFVSNDMSFSIERKAILFEMLSHPERTKEDLLYLLEWFYENVFSTIEPRIAKIHSKAVNEIEREISDSGEKFLRAIIKNIDYTRNEVLERTVICPSYFSEFLISNASIPFVKEDMYTIGFRFKEVMAIPKEALEITAETFDALAHEKRLAIIRYLSAGRSSGNELARALNLSNYEVGEHIGILREAGMVLAEKANQVTYFTLDKAIVRQEISRALEDLLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F570</accession>
    <name>I2F570_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07073.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1385"/>
    <dbReference type="EnsemblBacteria" id="AFK07073">
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        <property type="gene ID" value="Theba_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1385"/>
    <dbReference type="HOGENOM" id="CLU_870986_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="37311" checksum="2AB7E3438B4FDCB8" modified="2012-07-11" version="1" precursor="true">MLFLLIVVAILLGYVAYRLILREGGIFLGPYAIKFRKEPGPEDYLRRLKELQQRNQDFESRLVLGAATSKFPENLEFFKLAMDKVFSDLRDAKSEKEVEEVFLRGERLLKEFGAASSTNSIGVVTEYSKRLVQAQQEFYSLRKERDMELERKRYERNEEILKELESVLEGIRASNDEMAIRDEMNNAARLETGLDLSILDEGQNERYREVKNGFYRMAEEKVESLRSARYARYNRKAVERLKKLIDEFSENEKELSKSGSSLPVILKERIGSLNTSYFDGPTMQYFNYVYGYIFSLIDEDLKFEVTRIMTETEKDALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B7</accession>
    <name>I2F5B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1434"/>
    <dbReference type="EnsemblBacteria" id="AFK07120">
        <property type="protein sequence ID" value="AFK07120"/>
        <property type="gene ID" value="Theba_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1434"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="309" mass="33071" checksum="18B7B89344CDB8C1" modified="2012-07-11" version="1">MELIEERTLLGIDVGGTKTAVVLGDEALNILARAEFPTEPELGFQSFIKRLSSEIIGLTGDLIPSRVGISVGGPMDCKTGTLFNPPHLRWGTVNIVQPLVERFGFSITIEHDGRAGALAEGILGAGRGFLNIVFLTLGTGLGAGIIINGNIYSGSTGLAGEVGHMRVAVDGPSLYGKNGSWESFCGGTGISLYAHYRFPERFKRGTTTQDISHLALKKDPNAITVLEESGAYFGKGLAVLLDILDPDRIILGNLAWRLPKIWLEAALKMAAEEALIGDEARNRVVITELKDRIGDYAALIVASGMGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D9</accession>
    <name>I2F5D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731079.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1456"/>
    <dbReference type="EnsemblBacteria" id="AFK07142">
        <property type="protein sequence ID" value="AFK07142"/>
        <property type="gene ID" value="Theba_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1456"/>
    <dbReference type="eggNOG" id="COG3330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1065321_0_0_0"/>
    <dbReference type="OrthoDB" id="1711249at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032585">
        <property type="entry name" value="DUF4912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16258">
        <property type="entry name" value="DUF4912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="245" mass="28017" checksum="6CE6204D9E80B534" modified="2012-07-11" version="1">MSNEEIQTFLSKDPTIQDLRRYAKMMGINLKRTMKKKDITRVLKKFAQKSRQTSSTTTAKSSPSEILRPSKPVDAQIPSSYSRDFVVIHPVNPYWVYVMWDMSSWTARSVSDHSSKLLVRVSDITNIIYDGKNAHRFKEANISPDAGNWYFQVDFPDADYIAEIGYYVGGNFNSVLKSKITRTPRNSPKFSDYEIWVDLKKGSRKEYKASHEELVFERATKSSGPTGNPSSEEFIKTISKSKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F0</accession>
    <name>I2F5F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731087.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1468"/>
    <dbReference type="EnsemblBacteria" id="AFK07153">
        <property type="protein sequence ID" value="AFK07153"/>
        <property type="gene ID" value="Theba_1468"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1468"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_0"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="182"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="417" mass="45877" checksum="BE34923FAF48B472" modified="2012-07-11" version="1">MAETSLFQNALKQFNKAADVMDLSQSMRQVLSFPKRELTVNFPVRMDNGEIRVFTGHRVQHNVARGPAKGGIRYHQNVTLDEVKALAFWMTWKCAVVGIPYGGGKGGVCVNPQELSINEIERLSRRYFSEIQIIIGEGEDIPAPDVNTNAQIMAWYMDTYSMNIGHSVLGIVTGKPLEIGGSKGRTEATGRGVRVVAEEALRYKDMDPKKAKVAVQGFGNVGSYAAKLIAEEMGSRVVGLSDVSGGLYNPDGFDIDDLMAYRDQNNGVIEGYPKGQKISNEDLLSLDVDILVPAALENAITEKNARNVRAKIVVEGANGPMTPEAEDMILANNIFVVPDFLANAGGVTVSYFEWVQGLQHYFWDVEDVRRALHKIMKEAFGSVISTMNKYSIDMRTAAYVDAIEKVALATKLRGIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I9</accession>
    <name>I2F5I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1510"/>
    <dbReference type="EnsemblBacteria" id="AFK07192">
        <property type="protein sequence ID" value="AFK07192"/>
        <property type="gene ID" value="Theba_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1510"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="172" mass="18612" checksum="EF30C87C3E7CDE6C" modified="2012-07-11" version="1">MLSDTHGALSPLTRILQEVDQNTLIMHSGDFLYHGPRNPLPEGYDPKGLATLLAKFSGRIVGVRGNCDSEIDLELVGLENAASALTLLINDLGIFISHGHMKHEVPFERGIVISGHTHISLLRKDNGIIFMNPGSLSLPKDQTGGSYGTIDFKKGIISLRNGNGFELKTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M0</accession>
    <name>I2F5M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731133.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1549"/>
    <dbReference type="EnsemblBacteria" id="AFK07223">
        <property type="protein sequence ID" value="AFK07223"/>
        <property type="gene ID" value="Theba_1549"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1549"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039146_0_0_0"/>
    <dbReference type="OrthoDB" id="1201040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="37218" checksum="A7ABF6CEE72108A2" modified="2012-07-11" version="1" precursor="true">MKKSTRNFMIAISLSLLIILIVLFATDFSKSISYLSAANPGWIFLIFCLTFGTWLFEAITLKLFAAMRNLAIPFLFLFKITVIGTFFNGITPFSSGGQPAQIVFMQRRGISIGESTAMLVSRFLIYQTVITLLGAVAVFKAYPLVSQKISNLAVLSIFGFALNSVVLVGLVLFSLSPKLTDKLIHFVISFLHKIRIVKEKESLIEKAMRELRFFHSSMKELVRRPFVLTSASLSTLAQLICMISIPYFVALSIGTPVNYLEITAVQLILFLVVSLIPTPGASGVSEGGYVLFFKSFFGEGIGAALLIWRFFSYYANIIFGGLLSAHEIGFKSRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M8</accession>
    <name>I2F5M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731140.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1559"/>
    <dbReference type="EnsemblBacteria" id="AFK07231">
        <property type="protein sequence ID" value="AFK07231"/>
        <property type="gene ID" value="Theba_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1559"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="235963at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="448" mass="49391" checksum="6C8B88F28F3F06B9" modified="2012-07-11" version="1">MGILETKGLGKNFGENNVFRNADIELESGLLTVLGGINGSGKSILVKTISGDILPDSGKVIFEGSPVDLTSIAEARRLGISAIYQEYMLVPDLTVAENILLGSDKFTISRRKMNDQVSRFLEQLGLEFDPSSKVSSFSSDDQVLLEFAVAAFSRPKVLILDDLFSFVRGATRVKLLEMIDSFKKGGVAVLVTTSDPEVMVLGDRLFFMDYSGIKPLPLQTKESDIWKMLGVSPEYSVAPVGGEPLIDIENLADTGLDLRLKRGEVLCISCDNGVSVREFTRALTRQDPFSENSVAMLREAKNFFERFSSRGHSSEAEKYFSSNVKNTGLVSQIMLKKSRKFTSNRSLKKSFILNKESLVSVKSFLAGLGRAPGFSGLMRDDDTKLSHLRFDACDLFIFIRPLIGLDPVSTRALAEVLQEIADRSKAAVVISDEIMSRKLCTRIMNKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S5</accession>
    <name>I2F5S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CRISPR-associated protein, APE2256 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1614"/>
    <dbReference type="EnsemblBacteria" id="AFK07278">
        <property type="protein sequence ID" value="AFK07278"/>
        <property type="gene ID" value="Theba_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1614"/>
    <dbReference type="eggNOG" id="COG4006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747889_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013442">
        <property type="entry name" value="SSO1393-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09651">
        <property type="entry name" value="Cas_APE2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02619">
        <property type="entry name" value="TIGR02619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="354" mass="40169" checksum="31BE1C77C6D04ABB" modified="2012-07-11" version="1">MRKLCNMTSSGITDRLLNLNDPIGNREFGAEINSLASILSQSVLSSRDYLYFLTSDTEEGKKIGDALKLFFDCSKDMSFKNVSVNAISDLDDSRPDDFQNKGLRNLVKRIAEIYKHHMDNLLINATGGYKAQIALSLAFGMGVKIPVYYRFETFDGVIKLPPMPLSLDVELWLENKGLLDTLEMNSVINEKDLEREYDYRINFSSLPAEIKLLIDREQDSVGHMLSLSPMGEVFVQACRLSLGKLDVEASLKDSSVPIENRLKKSSKEAHSNKMISDNQSFIDKLVSIPFIEEVLVRGSSQKFDRNEFVCKQFGEIIKARYSTRGGTLYMEIRTTARNPYELEKAVEEIKRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S8</accession>
    <name>I2F5S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07281">
        <property type="protein sequence ID" value="AFK07281"/>
        <property type="gene ID" value="Theba_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1617"/>
    <dbReference type="HOGENOM" id="CLU_3119629_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="50" mass="5351" checksum="912713CB5F22987A" modified="2012-07-11" version="1" precursor="true">MSLPYKLFIGIIALAGVLGILGLISGTWSGLIIGLLCALFAWTMDQNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F632</accession>
    <name>I2F632_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1651</name>
        <name evidence="3" type="ORF">Theba_1728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731209.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1651"/>
    <dbReference type="EnsemblBacteria" id="AFK07314">
        <property type="protein sequence ID" value="AFK07314"/>
        <property type="gene ID" value="Theba_1651"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07385">
        <property type="protein sequence ID" value="AFK07385"/>
        <property type="gene ID" value="Theba_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1651"/>
    <dbReference type="KEGG" id="mpg:Theba_1728"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_2_0"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="238" mass="27341" checksum="A90AAA6B81F85E5F" modified="2012-07-11" version="1">MIPIYLKIRNYMIKQIEKGILIPGDRIPSERELVDLFKVSRMTVRHAIDQLVNDGILVRMVGKGTYVSSEKFATELNVLRSFSEEIISTGHRPSAKLIRIERGQAGNSVTSLLRIDSSHEVMRVERLRLVDDLEMAITVSYFPLSRAFPVDEIDFSATSIYNQIESLGLRIEKATETVTAEAADKRTANFLRVKDKAPLLKITRLTFISNNVPIEYMEGLFRPDRYFISQELYRQEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F645</accession>
    <name>I2F645_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1669</name>
        <name evidence="6" type="ORF">Theba_1742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
            <strain evidence="6">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731226.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1669"/>
    <dbReference type="EnsemblBacteria" id="AFK07331">
        <property type="protein sequence ID" value="AFK07331"/>
        <property type="gene ID" value="Theba_1669"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07398">
        <property type="protein sequence ID" value="AFK07398"/>
        <property type="gene ID" value="Theba_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1669"/>
    <dbReference type="KEGG" id="mpg:Theba_1742"/>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047250_1_1_0"/>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="132"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="224"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="382" mass="43082" checksum="16B4B8A35DFB4338" modified="2012-07-11" version="1">MIPDQFSSNSPGKVKKIVGPSFTYWAFVPNPLPPKLVYDNDLLFFLGEANRAMGEFSGFLSGSPGSRLLIRPLFRREAVASSQIEGTTSDIEDLYFFEADQNSVPLADDVREVSNYLKALEYGLERLKSLPISTRLFKELHSVLMSGVRGGYSYPGELRRTQNWIGKPGCTLNEADYVPPPPEELNDCLGELENFINSESRLPPLVRLALVHYQFEAIHPFVDGNGRVGRLLISLLKTYWGLMDQPGLYLSGYFEANRQEYYSRLRSVSFEGDWNGWIFFFLKAILQQSELGKNKLKEIMDLRSNWIGRLKPVSSALPLALIDSLFENPVITIPLAAERLNVTYVSARRAVTALCEKGVLSQTDQSKYGKKYIASELIEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F676</accession>
    <name>I2F676_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731264.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07429">
        <property type="protein sequence ID" value="AFK07429"/>
        <property type="gene ID" value="Theba_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1777"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_1_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="48956" checksum="2934948341B1170C" modified="2012-07-11" version="1">MKYYSLIDKVYSEKNLLKAYGRVESNRGAPGIDGVTVEIFAEKLPEEIERLSGEIKRGEYKPMSLRRVEIPKADGKTRQLGIPAVRDRVVQQSLKEVLEPIFEEGFHPSSYGYRKGRNAWQAVEKAKAFASKYGLCNVVELDLSECFDTLDHEKIIDSVAERVSDGKILKLIRAILKSGVMEDGVWKATETGSPQGGVISPLLANIYLNEFDQKMKARGIRIVRYADDILIFSKTQEEAREFLAIAINILEIDMKLKVNRNKTRITTLEDGFHFLGFEIKGERVGIEKSRLKRFKEKVRKLTRRNQSRPVKEIVKQLNPLLRGFASYFRIVDFQSILRGLLSWIRRRLRAIILHQWKTTKKLNRVLRRTGWKEKVNMRMNKWRSSHSKAANYAIPNRFFEEMNLVDMTKYHHPLSKFPILDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F698</accession>
    <name>I2F698_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit Na+/H+ antiporter, MnhB subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731282.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1800"/>
    <dbReference type="EnsemblBacteria" id="AFK07451">
        <property type="protein sequence ID" value="AFK07451"/>
        <property type="gene ID" value="Theba_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1800"/>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069132_3_0_0"/>
    <dbReference type="OrthoDB" id="1836204at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="121"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="26249" checksum="FA087F1EE8590717" modified="2012-07-11" version="1" precursor="true">MKRMISALIALLFFFMIVTVLNSDSSDSMGIPRYGEVKLSERVSAKYIEKSVNGNEDEINFGVTADAETGSANMVTSIVVNYRSFDTLGEVTVLFISATGVGLLLGGGRKRVGSAISVSPVVKIASRVISPLLMVLGIYVFVHGHLTPGGGFPGGAIIAAGFLLLVAVDDEKRASKGLKILEGTMGLLYVLIGIAGLLISGSFLKNFLPTGVVGELFSAGIIPVVYSVIGIKVGAELSGIVDDFISEGGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6A2</accession>
    <name>I2F6A2_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Formate hydrogenlyase subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1804"/>
    <dbReference type="EnsemblBacteria" id="AFK07455">
        <property type="protein sequence ID" value="AFK07455"/>
        <property type="gene ID" value="Theba_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1804"/>
    <dbReference type="eggNOG" id="COG0650">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_0"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="302" mass="33152" checksum="888076A7FB2FB317" modified="2012-07-11" version="1" precursor="true">MFMNIVITILSGIALLIVAFVYTVTLEGIARKIDARIQRRYGPPFWQNFIDIFKSLTKHSISHGFIFDFGLLMALGGTIATVFFVPAGSLAVFPGIDNVFVVIYLLAIGLLGMAMSAVGSGNPNASIGIGRALAQMLGYELPFMIVILGVFFHHGTSSLSDLVSIQIAQGAYNAWLMPIGGVVAFISLIGMLGKKPFDTFIAPAEIASGPLVEYSGKYLGMLMIQHAFATFIEIGLFVNLFLGGGRTLWEFLLKFLIVYFSIVIISATIPRFRVEQAIKFYWKWPLILSFVQVIIVVFVMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B1</accession>
    <name>I2F6B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GHL10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1813"/>
    <dbReference type="EnsemblBacteria" id="AFK07464">
        <property type="protein sequence ID" value="AFK07464"/>
        <property type="gene ID" value="Theba_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1813"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768775_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GHL10" evidence="2">
        <location>
            <begin position="12"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="337" mass="38977" checksum="30CE86E6823CB684" modified="2012-07-11" version="1">MSGFRPEVWVPSKELVSRESLSRMIEKLDGINAFRAYIQVVNRADSYYSSNMLPPAEELVQDFDALQMTIEKACGREFKISAWMNVNLVWGFGKQRPLSEKHVLNRRPEWITVDESGNSMLECSSSNLEEVFGPYIDPGIPDVREFTAQIASEISNYDVEEVHLDFIRYPFKSFGYNPLALAEYRKWLNREELIESKDTFVRFRIYSITRQVSMISEVVRAKGKKLSCAVYDDYSERAVSERLQPWIEWLKSGLIDSAVVMAYGKEPDEVITRIEKIRSLHGSLKDIKIGLGAFNYTGRWDEFAELIKRVQKLRPDEITLFALGSVDEELRKKLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G5</accession>
    <name>I2F6G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00725 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1868"/>
    <dbReference type="EnsemblBacteria" id="AFK07518">
        <property type="protein sequence ID" value="AFK07518"/>
        <property type="gene ID" value="Theba_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1868"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107614_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="176" mass="18814" checksum="D46F045BDE40B6E7" modified="2012-07-11" version="1">MMLHVTVIGYSGSISASPVKELHGICEEVGRTLARHGHVVMTGGRDGVMELVSRAVSKEGGRVIGVLPAGDEGNTHNEIRIRTGMDFALRSLILTKSADVVISIGGQAGTLLEIISSYSYGHPVILMGGTGGWTDRIGSVLIDGKYLDERRTAEVMRANSIEDLERLLEEAENGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q6</accession>
    <name>I2F6Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731403.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07609">
        <property type="protein sequence ID" value="AFK07609"/>
        <property type="gene ID" value="Theba_1966"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1966"/>
    <dbReference type="HOGENOM" id="CLU_1045122_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="266" mass="30947" checksum="EB61564E4659D7D7" modified="2012-07-11" version="1" precursor="true">MRLNKDLFERRLGVFFMVLWILILFFYLTWDGWLYEWCDCGYNGPSQHFDLDITDMEYSRSPDNEITYLSTNNLHNLIYLCYLVFLIGWLGLLFDLEWAKQGAMATMGISFVAALSTLNLSDHVYLLQVVYDIVHLSGLVMGAYLFSKYYLKTSKSLPVVLGTWAIYLVSHVIFTPWPFWENVGQAYFSVNQINDLPFFLFGMEYIVVVVILLAVNTLIVKLNGRTSNRFLRVLIPLGLYFLLFMIMYSTDLIIVQNVNMNTCALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S6</accession>
    <name>I2F6S6_9BACT</name>
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        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731421.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1986"/>
    <dbReference type="EnsemblBacteria" id="AFK07629">
        <property type="protein sequence ID" value="AFK07629"/>
        <property type="gene ID" value="Theba_1986"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1986"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1576656_0_0_0"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="19191" checksum="E1498930BE4154A0" modified="2012-07-11" version="1">MSRYWETMRAFFDRGADSCESHMKNNVKESAAFYGEMARLVPVTTGIRILYLGCGTGLEIDEIFKLNSTARVTGIDLSEKMLEILRSKYEGKKGTTNLLPVPTSKSNCRWRDSTLPFRFNRCTTSDKNKSYRSTGRFSAVRGVIEHISKPITLSVLRLRRWSCSTDTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T3</accession>
    <name>I2F6T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488061.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07636">
        <property type="protein sequence ID" value="AFK07636"/>
        <property type="gene ID" value="Theba_1993"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1993"/>
    <dbReference type="HOGENOM" id="CLU_2206908_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="107" mass="12088" checksum="8E1D15E2BE1F9900" modified="2012-07-11" version="1">MYIVCDLTYAVSESRSTEALKMILETLSKKLLLGAQGDTLNMRAETEDTIEVQIMALKGSCSFEEVVPRINEYLSLISRALETSFPDYRVVSSYIYLDGEETPYLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F716</accession>
    <name>I2F716_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731496.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2085"/>
    <dbReference type="EnsemblBacteria" id="AFK07719">
        <property type="protein sequence ID" value="AFK07719"/>
        <property type="gene ID" value="Theba_2085"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2085"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294371_0_0_0"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07484">
        <property type="entry name" value="Peptidases_S8_Thermitase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034084">
        <property type="entry name" value="Thermitase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Flg_new_2" evidence="7">
        <location>
            <begin position="121"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="7">
        <location>
            <begin position="453"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="663"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111414" checksum="7F53A8E9D0D06C8E" modified="2012-07-11" version="1" precursor="true">MKRKLLLFASLTVFLILMLTGCPNGSKSFTLTIMTLPDAGIQIIVDLVNKVTPFSQKYQEGTNVEVQITSPQERDTSAFVGGDDTKYTFQQWNDANNTNPRNVTVNSNVTYTAQMGVQYKVETSSNPAGAVVTGGGWHNKNANATLTALVMDGYTFSHWLVNGTNSGSSITIGVTINEPKNIVAVYTTDPVPCNFTVTTSPDLALDIEIDGVSFTSPKGMIVNSGTTKQIAVITPQEKDISPWLSGIDSRYIFDQWNDGNTSHTRNVIVNTDITYTANMDAEYRVTVDSSPSEVSEVANFWTARGNVWLFDFSGDLGPYNFSYWYVNGQNLGSARPIEIVVDKPYHVTAVFAEQETQYTLTVTTSPETGLNIIIVGIAYVSPKTVVLNSGTEAEIEVVSPQEKEKSGQVTGTDTRFTFVRWSDTNTNNPRTITLNSDMTYTAEMKVEYKVTTGTNPAGGTVDGAGWYVAETVKNFTAPVRAGYTFSHWVINGANMGDANPIAVNVNSPKNVIAYYNAETTTKNIFGTVTPYTGNIKTADLNKIEILSNTEIRTTYDRPEFIENEYLLKVESFKEVESSFSSASIASIDVIERIENYYGELKYLHVRTTASEEELKRLPGVVQVSKNSLFYALSTTPNDPSYPVQWNYPVMNLPQAWDYTVGSRSVVVAVIDSGFSTSHPDLSGIFESGYNFIDSNTDVSEPLESEDSHGTHVVGTIAALTNNALGVSGVTWGGLGITLIPIRGIKDAAALMNSLIYAVDHGAKIINMSLGGAVDSPAVHDAVKYAARNGVVMVAASGNNGDGNILYPARYPETIAVGAIWEDEGTIKISPYSCYGSELDVVAPGGYMRSGTDPNGIYSTGWTPSGNTYMYMQGTSMATPHVTGLVALLMGAGLTDPDDIRNVLHNTAIDLGSPGRDDDYGWGLVDAEAALDSIASPQEFKVFLRNPSTGTNIASTNLSDSGAYHFSDVSSTQVKIFAWRDMDESGTIDTGDLLGYFNYSGGTPDLDNAQTVTLSGGDNWVDFEFAPIVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F735</accession>
    <name>I2F735_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731513.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07738">
        <property type="protein sequence ID" value="AFK07738"/>
        <property type="gene ID" value="Theba_2104"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2104"/>
    <dbReference type="HOGENOM" id="CLU_959109_0_0_0"/>
    <dbReference type="OrthoDB" id="2074345at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="31822" checksum="0F0D323F6704D4DA" modified="2012-07-11" version="1" precursor="true">MKIALGLIFVLVGVLLIFGLFTGDTLLNALVNLANFWPIILVLVGMSILASIRGLRWIRYLNTILIVAFVLFVFFWPSPFLAGKKAVSDTVVLESSDSAASIEIQVDLAMSNISLEPLRDEVASSTVAVVDYAVRGSGLKIEQDITQLSQRFIMKPESNVSWLGTSTVVMKLNPAYDYVLKFNGAVMNCNFSLGELRVDELRINGAIVKAIVSMSAAGFTNMKVNAAIINSEIHIPENIRAILKPSAAIKNVKTDLPYTGNEEYVFESVSFDFSSYITLESAIMNLKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F736</accession>
    <name>I2F736_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731514.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2105"/>
    <dbReference type="EnsemblBacteria" id="AFK07739">
        <property type="protein sequence ID" value="AFK07739"/>
        <property type="gene ID" value="Theba_2105"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2105"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_0_0_0"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="32838" checksum="80E85064E15E3745" modified="2012-07-11" version="1">MKTLVVVNPNASHGEAGRDFEKSISSLLREEIADYDIHITTGPEDALSFVTKNPNYDRIISVGGDGTLNEIVNGMIKGKSNASVGIIALGSGNDLARTINLKHNYREMVKIAAGENVRKIDLLKVSYVDMNGVKASRYAVNVVGAGFDAAITVRMIKSRFKTSGKMAYLLSFLIEFFTSKTYPLTFIVDGEETSGSYFFLTMANGNYFGGGMRIAPKALVDDGYFDVVGVSKMSKLRLLYHFPKIYRGEHLVVNTVSYRTAKNISLKSDRDVIIQMDGEVVGSLPMEISICEKALKIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F742</accession>
    <name>I2F742_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine 2,3-aminomutase</fullName>
            <ecNumber evidence="5">5.4.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Theba_2111</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine = (3S)-3,6-diaminohexanoate</text>
            <dbReference type="Rhea" id="RHEA:19177"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57434"/>
            <dbReference type="EC" id="5.4.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the radical SAM superfamily. KamA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731519.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2111"/>
    <dbReference type="EnsemblBacteria" id="AFK07745">
        <property type="protein sequence ID" value="AFK07745"/>
        <property type="gene ID" value="Theba_2111"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2111"/>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_0_0_0"/>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022459">
        <property type="entry name" value="Lysine_aminomutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00283">
        <property type="entry name" value="L-lysine_2_3-aminomutase_(LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03820">
        <property type="entry name" value="lys_2_3_AblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="112"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK07745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="49034" checksum="B722935797FDE9F6" modified="2012-07-11" version="1">MRDYREIPMWRDVTPAQWSDWRWQVANRVKTVDALRQIIDITEEEAHGVAECLRTLRMSITPYYATLMDPNNQRCPIRRQAVPTDKELKIDKWDMIDPLHEDEDSPVPGLTHRYPDRVLFLITDQCSMYCRHCTRRRFAGQLDRARTRKEIDDAIEYIRETPEVRDVLLSGGDALLVGDDYLEYILNELREIPHVEIIRIGTRTPVVLPQRVTPELVKMIRKYHPVWINTHFNHPLEITPDSTRACEMLADGGIPLGNQSVLLRGVNDSPYIMMELVHQLVKIRVRPYYIYQCDLSQGIGHFRTSIRKGIGIMESLIGNTSGLCVPTFVVDAPGGGGKIRVMPQYNISESDRVVVLRNYEGVITTYHEPDDTSSDVDDRVYREKYEFTGVSDLLYGNSMSFEPTTLQRRDRIKKWKEKKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F778</accession>
    <name>I2F778_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731549.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07781">
        <property type="protein sequence ID" value="AFK07781"/>
        <property type="gene ID" value="Theba_2148"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2148"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228179_0_0_0"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="219" mass="25292" checksum="22E591ADD9F4074C" modified="2012-07-11" version="1" precursor="true">MVRGIIFDLFGTIVSNARLFRPVCSKMAEESSAEVAEIERDFVNLYGHYFKDCHKMPFQPERYYYYLLISDLIDKYDLPGDMEAYCNFMYDSFSKFRAYPDARILRAIVNKYSVAILTNADNSFAEKVVKRNKIPHHFLLTSESARSYKPCEVIFEKLLSMMEIEKRHVIFVGDSIQVDMLGASAAGIKGILIDRSRSYLDYAPRIESLEELPSLLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D3</accession>
    <name>I2F7D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487685.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2203"/>
    <dbReference type="EnsemblBacteria" id="AFK07836">
        <property type="protein sequence ID" value="AFK07836"/>
        <property type="gene ID" value="Theba_2203"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2203"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_2_0_0"/>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="130" mass="14178" checksum="43E42D3CE04C2AD1" modified="2012-07-11" version="1" precursor="true">MFSVLSFIAYAPAGDVAAPSTDPGAATSGGFSGIIIWLVLMVAFFYFLIIMPQRKRDKQFKQMMEKLKVGDRIVTAGGIIGKITMIKPDSLRIRTGTGTELDVTRKAIAVVVNKGENDKEEVEPDVNVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E4</accession>
    <name>I2F7E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pfkA</name>
        <name evidence="17" type="ORF">Theba_2216</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2216"/>
    <dbReference type="EnsemblBacteria" id="AFK07847">
        <property type="protein sequence ID" value="AFK07847"/>
        <property type="gene ID" value="Theba_2216"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2216"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFK07847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="320" mass="34259" checksum="2C4A946DA46C9601" modified="2012-07-11" version="1">MIKKIGVLTSGGDSPGMNAAIRATVRTAYTDEIAVVGIRRGYSGLLDEEFIDMDYSSVGGIMEKGGTVLRSSRCEEFRTEEGRTKAADLLRSNGIDALVVIGGEGSLNGAKLLMDENGIPVIGLPGTIDNDIAMTDMCIGVDTCLNTCVETIQKLKDTASSHERAFVVEVMGRNSGYVALASGMAVGAEAIIVPELPVDYEAIAEKIWNERKRGKINCIIVVAEGAASAYTVARHVEHRIGYETRITILGHIQRGGSPTAFDRVLASRMGYASVKALEEGKAGMMMSLNGGKIKGIPLEEVLSHKKELDMELMEMAKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F6</accession>
    <name>I2F7F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ORF">Theba_2229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731618.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2229"/>
    <dbReference type="EnsemblBacteria" id="AFK07859">
        <property type="protein sequence ID" value="AFK07859"/>
        <property type="gene ID" value="Theba_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2229"/>
    <dbReference type="eggNOG" id="COG2160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_0"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="371"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="508" mass="57297" checksum="8CBBEB89ED93F646" modified="2012-07-11" version="1">MRKGGLIIISTDSLEVWFLTGSQELYGKEVLRKVEENSKKLVNALNEKITAPAKIMWKPVLKDAIQIKATIDEANSNNKCIGLIAWMHTFSPAKMWIAGLKSVDKPFLHLHTQFEQKIPWDTIDMDYMNTNQSAHGGREFGFISTRLELKRKVIAGHWTDKAVIAKLEDWLRAALGWNEAHRLKVARLGDNMRDVAVTEGNKVDAQIDFGYEIHGFAVGDYIEGYFKKVKKSEAEELVKEYLKEYPVVKSTVSEEEFQASVREAARIEISLRRFLEDGGFKAFTTTFEDLHGMKQLPGIAVQRLMRDGYGFGGEGDWKSAALVRIMKVMAEGIDKGTSFIEDYVYHFEPGNVKELGAHMLEVCESIADGTPSLEVHPLSIGGKEPPTRLVFNAKAGPAVQACIVEFGDRFRMIVNELDVVKQEVAMPKLPVARALWIPKPDLSTAATAWILAGGAHHSSMSYTVTTEQLEDLCEMFGIEIVVIDENTDIREFKKELRYNEIYYKLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H9</accession>
    <name>I2F7H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731641.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2253"/>
    <dbReference type="EnsemblBacteria" id="AFK07882">
        <property type="protein sequence ID" value="AFK07882"/>
        <property type="gene ID" value="Theba_2253"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2253"/>
    <dbReference type="eggNOG" id="ENOG502ZBA5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721127_0_0_0"/>
    <dbReference type="OrthoDB" id="1274457at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="403" mass="45466" checksum="0365E2F55B8B4627" modified="2012-07-11" version="1">MSEAGKINILSQLFLNEELSKDNSRSLTERLSKAKKAGLQKLIIWSVRPEYLSSLVSICRGVGISPHLWYPMLADAPVDFDTDAFKIVRTLDDGRSEILESQKAGGEEFEFLCPNKVRQEEAFLSRFEKILGLADFDGVFLDRIRFPSPANGIGEMLTCFCDTCKEMSSATGSAFEEAVHGFVKKLGSKIGMDEVLETLKEFYRITGEFLEFRKSSVLQLLASYADRARNLGLEVGVDLFSPSLRNIVSQDYERISRHVDWMKPMVYCKTMGPAGLPMELLSLAKILVEHASRLSEREALEIIGELTGLLLPESFDEIRMKGIDQKNYELELNKIDQMNLNPVIRIFPGFEAVNLPPVCSVGLEEVRNYVDATLRKGHDGFVLSWDIRHISDAILEYVGDRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7K7</accession>
    <name>I2F7K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2282"/>
    <dbReference type="EnsemblBacteria" id="AFK07910">
        <property type="protein sequence ID" value="AFK07910"/>
        <property type="gene ID" value="Theba_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2282"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="36564" checksum="A2D974C67B6C23F7" modified="2012-07-11" version="1">MMNRQKSEQLLQCRNLVAGYRIKSGFVHAVDDVSFDLERGGFLGIAGESGCGKSTLAFAIMRLLKDNATIENGSLFFKGTDLVGLREEEMKKIRWVDISMAFQSAMNALNPVLSIGEQLTDVIHAHGEVRQSEARDRAIEALKLVDIPRDRFNSYPHQLSGGMKQRVMIAMALILNPDLIIMDEPTTALDVVVQRTIIEKIQELRKSLGFSVIFITHDLSLLVEISDTLAIMYAGKIVEYGNSDELFNMPLHPYTIGLMNSFPSLTGKITRMGGIEGKPPDLLNPPEGCRFHPRCPHAMDICEKSCPALQKVDPRHSVACFLHKGAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N4</accession>
    <name>I2F7N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, TM1802 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731692.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2310"/>
    <dbReference type="EnsemblBacteria" id="AFK07937">
        <property type="protein sequence ID" value="AFK07937"/>
        <property type="gene ID" value="Theba_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2310"/>
    <dbReference type="eggNOG" id="ENOG502Z952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466766_0_0_0"/>
    <dbReference type="OrthoDB" id="709504at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013389">
        <property type="entry name" value="CRISPR-assoc_prot_Cas8b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09484">
        <property type="entry name" value="Cas_TM1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02556">
        <property type="entry name" value="cas_TM1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="584" mass="67555" checksum="63368832741428F5" modified="2012-07-11" version="1">MLKSTYEIGRIVSRGKDETQMYTTDIGETYIHELTIVLENNGETIRYSGCDKREKTRRNYLFREKKGNIKVPMSLTLRDAGKGSKAIIEKFINFGTQNKTPFAEKVAAALVESEEIISATLDEMAENLPKKEGRFYTVVIKQGDRELYPGDLDEFRQIFLRNVVSAASNTFGTCFVCQEEKPIGMKASDIFKFSSFDKPGFAHEMNDKNYYVNMPLCQDCFSKIALGKKVLDEELSMNFYASRVYIIPRFHSSESALIEGAVDQIRDIKRISNLKDTVHKANRFKGFETHMLCEISEGLYSSLNFIFYTVNNQEMKINLSVLDVPPSRLRNMSQKISDIEEELRTVFGNEEYLPSVLFGSMYDVFKDNRLRTFFDYIEALFKDQPVSLTPLKRGTLEFIGSRKLRGEPYATRAKQLITVAFFIDRLQKNAEGGVPLMGKDREDRIEEFFNKYPAFFRTDEEKFLFIVGQVHSRISRFQREKNIASTVDLRLKAYNMRPLDFMNHFKDLKWKTTQYSKEMDPVRVRGPIMNLLQIADKYLIPSGYEWKASIEDLNYAFLAGELATGVFRRESDPFEAEIVQEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7V1</accession>
    <name>I2F7V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2386"/>
    <dbReference type="EnsemblBacteria" id="AFK08004">
        <property type="protein sequence ID" value="AFK08004"/>
        <property type="gene ID" value="Theba_2386"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2386"/>
    <dbReference type="HOGENOM" id="CLU_896608_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="34613" checksum="F5D81D94473C7BC0" modified="2012-07-11" version="1">MERLKKYLDDVRTFLPGTNPKKVDEILREIESHVLERAEREHGEINDTAVAMTIKEYGSPEEVAARYYEGGPIIAPHLKNYLFMYTGILFAIHLGLHLIAFVFGENGAIFDFRGTDLLSLLSQLPVTFIFDFGLVSLILYFVTQAKATAKLPHFTYFIRAEKTPSMGKRIGALIGSLVGAGITFLAFTYGPFYLGGGELTEIAIIALDSFKFALFLAFGLLVIDSVSNLINIFNYSRFSKIVSNTLGLVFLFLAVSPDYKPDIASYLSLNPSSIDHPLLVAILFLMAIVIIVDLVFETIKFWVSRIVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W7</accession>
    <name>I2F7W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate formate lyase activating protein-like uncharacterized Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731762.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2403"/>
    <dbReference type="EnsemblBacteria" id="AFK08020">
        <property type="protein sequence ID" value="AFK08020"/>
        <property type="gene ID" value="Theba_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2403"/>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_0"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
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        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
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        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="74"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="308" mass="35259" checksum="BE20DE4CDC4DFEE2" modified="2012-07-11" version="1">MDSNAERLVKVQKAIENTRERLHSCDLCPKKCRINRFEVPGFCMQRIEPRVSATVLHFGEEPPLVKEGGAGAIFFSGCSMSCLYCQNFAFSQKNSGKVFSFEELSRHFMKIQEEGAACIDLVTPTPNLYGFLKAYELALKEGFSLPVVFNTSGYEEVSTLLLLDGIVDIYLTDIRYTDDEVGKKYSLVPDYWTVTKKAVKEMFRQTGSFREENMRGVIVRHLVLPEGIAGTEEMAEFVAFELSSSVPISLMSQYRPVYRAREYYELSRRISEEEYDHALNVIDAFGLTGWMQHFESNEGYRAKPLRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y9</accession>
    <name>I2F7Y9_9BACT</name>
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        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2427"/>
    <dbReference type="EnsemblBacteria" id="AFK08042">
        <property type="protein sequence ID" value="AFK08042"/>
        <property type="gene ID" value="Theba_2427"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="244"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="496" mass="55479" checksum="44796AE7EEC852F2" modified="2012-07-11" version="1" precursor="true">MAEKLLEMRNISKRFGGVLALDSVDFEIEKGEIHCLVGENGSGKSTLIKIISGIHSPDPGGEIYVDGRRISHQKSSNSVREGIQVIYQDLSLFPNLTVAENIAISSRVETGSRLMKWKETEEESMKTMDKIGVSLDPRREVSELSIAERQVVAICRAINAKARLVIMDEPTASLSKKEVQSLIRVINELQNREISTIFVSHKLDEIMEVAQRVTVLRDGKKVGAFDASELTRQRLSFLMTGKEFEYSKLTPYSGHEVILEVRKLSRRNNYKEIDLKVHKGEIVSITGLMGSGRTEFVLSLFGMNRPDDGEIFVEGKRVNPGSALDAMRAGIAYVPEDRLQHGLVMEQPVSKNIVLTVLKRILSRIRLLSKVKERTEVRRWVDELSIKIPSVDSPVNTLSGGNQQRVVIAKWLAINPKVLILDSPTVGIDVAAKDSIYKIIRELASEGISIIMITDEAEEAIYHSNTTYIMSSGRIIGKYNSSELTEKELYEKINGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F813</accession>
    <name>I2F813_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2454"/>
    <dbReference type="EnsemblBacteria" id="AFK08066">
        <property type="protein sequence ID" value="AFK08066"/>
        <property type="gene ID" value="Theba_2454"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2454"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="31137" checksum="8B460FC5824F684C" modified="2012-07-11" version="1" precursor="true">MKKAVLLTAFILLLAILMLARSGQLVLVEKGRFTMGDTWGDGYDNEKPTHQVTFTYDFYVGKYEVTFDEYDAFCEARGIVKPDDEGWGRGSRPVINVSWWDAIAYCNWLNAKYKLPKAYDDDGNLLDKDGRVTADITKVVGYRLPTEAEWEYAARGGNKSENYKYSGSDNVGYVAWYDSNSESKTHEVGKKLPNELGIYDMSGNVWEWCSDGHINYSGWADTNPIMSLLARGRVRRGGSWVNFATYARVAFRSFYKPDSMYYYLGFRVARKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F836</accession>
    <name>I2F836_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731821.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2478"/>
    <dbReference type="EnsemblBacteria" id="AFK08089">
        <property type="protein sequence ID" value="AFK08089"/>
        <property type="gene ID" value="Theba_2478"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2478"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024978_0_0_0"/>
    <dbReference type="OrthoDB" id="627025at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="660" mass="74524" checksum="B2194D4E62E206AE" modified="2012-07-11" version="1" precursor="true">MKRLITLVFLLAAAVLCASVSYNTYTVGIGSFLVKSQEAFEPTEVLYGEFLSPEDLFVRDGKLYVADSGNSRIAVLDGKEVSYLAEWEVLNPQGIYVDETGTLYIADSWARNVYKYDGQGVQTGVLSRPDSPLYGKSNDFIPLKVAADRRGNVYVLSQGVTNGLVVFNRDGKFVGFFGANEPDVTLRMILQRLFFTQSQKEQLLRIKPPSPGNLVVEDSGLVWTVTTGLTDKAIKRFNVAGTNIYGDLDFSSSDFIDLDIDAFGNVYALSSTGLIFIYDSYGNLLFLFGGQSYYENRRGLLRSPVAIDVAGDGRIYVLDKEDGTITVFSPTAFGSLVLKGVSYYNQGMYLEGEAIWREIQKLNSSFLLTYKVLGNIEFKRDNYGQAFDYFSLAQDKRSYSEAFWHLRNDWLQKVVGLLFVALVALAVFDLVRSVLKRQGKIKPRSRAGREIRFRLFRELKASLKFLKNPFDAVYEMKRNGAVSFSTATLLYIWMYVQNVLILYLASPLFVGFRARNIDFLALFYDTYRLLFLWIVGNFLVSEISEGEGTFKHIYIGTIEAFLPILLFALPLALVTNLLTLNEAFIYTFSMQALNVWSLVMLLIIISQVHNFTFGETVKNVLLTLFAMLLLALLIFLVIILLREEIDFFVSIVQELIFHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F838</accession>
    <name>I2F838_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2480"/>
    <dbReference type="EnsemblBacteria" id="AFK08091">
        <property type="protein sequence ID" value="AFK08091"/>
        <property type="gene ID" value="Theba_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2480"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="286" mass="32115" checksum="904F49A83A9F2BCC" modified="2012-07-11" version="1" precursor="true">MAFLGPYAVIFTIFIIVPIIIAVLLSFTNFNTIQFPDFVGLKNYISLFTYDDVFMQYVLPNTIKFALIVGPLGYALSFFLAWMLAQIPRVPRTILALIIYSPSMTVGVAMQVIWLTIFSGDKSGYLNSLLMNLGLINQPVQWLQSPQYLMITMIIVTLWSSMGVGFLAMLAGVLNTDPELYEAGYVDGISKRWQEIFYITVPLMKPQMLFGAVMSVVSTFQAGYIGVLLSGSNPTPQYAGQLIVNHIEDYGFLRYEMGYAATISVVLLLMIWISSKFVWSIFGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F847</accession>
    <name>I2F847_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2490"/>
    <dbReference type="EnsemblBacteria" id="AFK08100">
        <property type="protein sequence ID" value="AFK08100"/>
        <property type="gene ID" value="Theba_2490"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2490"/>
    <dbReference type="eggNOG" id="COG0731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058377_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040084">
        <property type="entry name" value="GTPase_Obg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01083">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="35994" checksum="6A96FC5B01027CC8" modified="2012-07-11" version="1">MSHVYGVVPSRRLGRSLGVCTIPFKTCNYACVYCQLGRTTNMTNTRQTFYPPEEILSEARRFIEAHGEESFDVVTVVGEGEPTLYKPLDAIVRGLREMTGKPLVLITNGSLLFDRELVEEIKDFDIVMPTLDAKDEESFKRINRPFGKLTYEKVYKGLLDFSKEFKGEIWLEVMLIKDYNDSDGFLRELKKKIDQIKPARVYINVPARPPAESGIEVPSESAIEFARTLLNAESIENLPVSSFTTSEKEALDAVIEIIKRHPMSDKDIRSFVESQFKEESVTGLLKRLAENPNVEKKTYHGNNFYRYVLATRRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F873</accession>
    <name>I2F873_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08126">
        <property type="protein sequence ID" value="AFK08126"/>
        <property type="gene ID" value="Theba_2521"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2521"/>
    <dbReference type="eggNOG" id="ENOG5032YJ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1729582_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="17751" checksum="9C7FE84933B767BE" modified="2012-07-11" version="1">MDSEKLTEQEWHKKQAIVNFNLTWDLIDKKDRTAEDDLLMIHAAHASRFHWGVVGTPIEFARGEWQVSRVYSLLNMAESALYHGELSLKYCTDNAISGFDLAFGYEAVARAYMIAGKRDRMDEYMKLAREAADLIEDEQDKNYFLSELESIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F874</accession>
    <name>I2F874_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489561.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2522"/>
    <dbReference type="EnsemblBacteria" id="AFK08127">
        <property type="protein sequence ID" value="AFK08127"/>
        <property type="gene ID" value="Theba_2522"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2522"/>
    <dbReference type="HOGENOM" id="CLU_1271057_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046272">
        <property type="entry name" value="DUF6305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19823">
        <property type="entry name" value="DUF6305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6305" evidence="2">
        <location>
            <begin position="47"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="217" mass="23380" checksum="8DF3F81DD7B0E00B" modified="2012-07-11" version="1" precursor="true">MLHLDSAIEDCGGEYMKPKISLFLSVIFITFLISPLYANAIEPLARPPIIATAIGDGAASDVLALVCEIHGIDYENILQLKPEEFMEKLDSKNAPGTLAIAPGAMVEGDLYTLCGVEEIDVGQEISRIEELISIAKARGVPVVAIHIEGGFTSPDNDPRQSFDLLMPKADYIILVSPEGPSEYFSALSEQTGVQLIVVDKAERILDALDLLFSMSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F2</accession>
    <name>I2F8F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase-like glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731915.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2605"/>
    <dbReference type="EnsemblBacteria" id="AFK08205">
        <property type="protein sequence ID" value="AFK08205"/>
        <property type="gene ID" value="Theba_2605"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2605"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_0"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="512" mass="56593" checksum="6CB7A93190A47FD5" modified="2012-07-11" version="1">MNFDEAVGRLFLIGIPGPEIDSETERTLREVKPGAVILFSKNIVDAVQVRALVDDIQRVLGYKPAIAIDQEGGIVSRLRDGFSVSPGAMAIAATGTTENSFVVGRILAREMNAIGVNWNLAPVVDINCNPKNPGIGVRSFGDSPDQVIAYARAFVEGMKSERVMSCLKHFPGKGRVDVDAHLDLPILDIPQSLLYEYELRPFKEIQADSIMPSHIYMPQLQASRVPASMSREILTDLARNVLNYRGVLVADDLGMGGVSNYFTPEEAAIQGLRNGMDYLTYCHDPVVQRRVKKILIREIEKSPELEKRFQESLQRVEKFRVEATSADRFSIEEIASQESLNAMQEISDRSITAILEDSSLLPLPIESVSGIFSVRLSRLVQVEDGPQKGVPTVAREIAQMSDCPIIDFSPNITVEEADRLAANSPGKGVRLVFTENAHLHEGQRKLLLKLSQRTGRTLVIALRNPYDAFLEGVKNCIISYGYEAVSQRSLKKILDGTIKAQGKLPIKIPQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H7</accession>
    <name>I2F8H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2630"/>
    <dbReference type="EnsemblBacteria" id="AFK08230">
        <property type="protein sequence ID" value="AFK08230"/>
        <property type="gene ID" value="Theba_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2630"/>
    <dbReference type="eggNOG" id="COG0121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105001_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="215" mass="24271" checksum="6363D16776AB8F78" modified="2012-07-11" version="1">MIAFKADKNIDTNWILDILKGISARGISSPHSDGWGYAVRGEGRETYNSSGAIFDSDKKLPQSRVGIIHSRKASKGYTVNLEHVHPFYTTVRGRNYAFCHNGTIYDFASDEGTTDTQRYLELLVSNLEIYETKRALEITSVFVAENYRYTSINALLTDYENVWAIRQNAETNDTEHALFLYERDGVRIVSSEPVEKFGDLLGNSIEIKNGESIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I1</accession>
    <name>I2F8I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like enzyme, predicted cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731941.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08234">
        <property type="protein sequence ID" value="AFK08234"/>
        <property type="gene ID" value="Theba_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2634"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539281_0_0_0"/>
    <dbReference type="OrthoDB" id="353872at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="462" mass="53150" checksum="BACA88E4FC9F297B" modified="2012-07-11" version="1" precursor="true">MKLKLVLVIVLISTVAFGDFFQRSDEYLRRQNELKSTLEFSLTFQQAKEIIVKHYPELKSDEEVREFIIERDIQRAIVDGVEMYYCDMEHNLFTRDPELVEREPEWSAGNVLLVRYLLEEYGPKQTPFASFKPAHSPYFNPKNYLVEYEVHTERSLLPDKGSLRIWFPLPLQTATQENISLLEVTPKEAVVGLPRTTGDIAYVLFEFDLSSLVEDLDISVKFTFTHYQQQFDIDPDQVGEYDKESSLYKDYTKSEGSIYFDERFEQLARSVVGDESNPYLQAKKIYYYVVDNIKYTFMAHASIEAAGIPESLYSFEHGYGDCGTQSMIFSALCRSVGIPARAPGGFQAFSGQLGSHFWAEFYLPNYGWVPVDTSAGQIATYTYGITEEERQDFIDYFFANQDPLRLVVQNSVDFLPAERPADTQLLEITLQTPFVESEFGNEEFDVTIAILDSLTMKTVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K7</accession>
    <name>I2F8K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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    <sequence length="540" mass="56451" checksum="87AA0E77D602318B" modified="2012-07-11" version="1">MKNGGLSLEKGSSKQLTIRSLVIGGFGSVVITTSSMYVALRMGALPWPTIFVAVMSLAILKALGRTNLNEINVTHTAMSSGAMVAGGLAFTIPGIWILEETSEVGFLSLLIVTLSGTVLGVVFTSLIRQHFVEKEKLPFPMGVASYETVVAGDEGGRKAKYLFSTMGIAAVFVAIRDGLGWIPAAWSSAWLYSKNIFFGTWISPMAVGIGYIIGPLFTGVWFLGAVLSYFLIIPVGVALGWFEDVATAAAFKDSLGIGLMVGTGLGILIKGILPRAKEIYGKSQKREKGRLGRQLILAPIFFAVVAVFLTTLTEMTLIPSLLTIVGVWLTTAMAASITGQSGINPMEVFGIIILLGVKVVSDIGTIEAFLVAGVVAVACGLAGDVLNDFKSGYLLKTDPKAQIIAETVGGVIGAVVSVVVLFIMFRAYGTMGPGTELPAPQAYAVSTMVGGLPNTPAFFFGLMIGILIYLIGLPGMTLGIGMYLPMEISSAAFLGGMISLISVKLNPKSKENGLVISSGLLGGEGITGVVLAIIRVLTGS</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
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                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
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                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
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                <person name="Swithers K.S."/>
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                <person name="Bruce D."/>
                <person name="Detter C."/>
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                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
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                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="30" mass="3510" checksum="26BB674AEE3F2649" modified="2012-07-11" version="1">MPWEIAGVCEPGLRCNKEEVNEKLKRFCDD</sequence>
</entry>
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        <submittedName>
            <fullName evidence="7">Putative nucleic-acid-binding protein (Contains the HHH domain)</fullName>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729964.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0032"/>
    <dbReference type="EnsemblBacteria" id="AFK05786">
        <property type="protein sequence ID" value="AFK05786"/>
        <property type="gene ID" value="Theba_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0032"/>
    <dbReference type="eggNOG" id="COG1623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787128_0_0_0"/>
    <dbReference type="OrthoDB" id="1139866at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="6">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="359" mass="40454" checksum="562E52E0DA2E6C3F" modified="2012-07-11" version="1">MERSELIEKIKKIAPGTPLRHALDDIQDANVGGLLFFVDDYKKYSHLMQIGFLLNCQFNPNKLYELAKMDGAIVVDDDLTTIVGANVQLIPDHTIPTNQTGMRHRAAERMAKETGRMLVAISKRRNTMTIFLGDFAYTLNNVETLTSKITQTIRTAEKYKEAFIEALQGIEFMERTGSLTLYDVVKTIQKGLMVALICEEAEFTIAELGNHGRFPSMQLAEILVNVNEEIESLILDFHEELLDQDSLEEVFDKMRSLGEKEISSFGVILRNLGYDINTASQAVEYFIRSRGIRFARHIPRIPLQVAINLGKEFGTFSNLLESSEDELKDVDGIGEKRASAIRHAIDVYKKSGEITVPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L6</accession>
    <name>I2F1L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729993.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0068"/>
    <dbReference type="EnsemblBacteria" id="AFK05819">
        <property type="protein sequence ID" value="AFK05819"/>
        <property type="gene ID" value="Theba_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0068"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039162_0_0_0"/>
    <dbReference type="OrthoDB" id="432299at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="1">
        <location>
            <begin position="293"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="493" mass="56874" checksum="F1055C42660B155D" modified="2012-07-11" version="1">MRLITKKMFLEYDYCPVRGWIERNEPREFRPTIAEDFRMKEGLDVGRRARSLFPEGILIEEPDPFEASFITERIIGDRRSVTLFEPAFISGDFVSRADVVRKEGEELDVFEVKSSLAGSSNTKDYIRDLSYTVSVVENSGYRVKKACLIMISRMYRKGDDDRKLFEIIDVTGEVSEQKIEIKAKLESASAVLTSTLIPSGLLGYKCRDCEHLRRCFGLERKQSIFELPRLGADKTDALIEKGYFYLEELPQEALGDKPLLQRVFRGAKSGRLVLDEPEELREKLNSLKYPIGYLDFETAASVIPLYDGLAPYEGIPYQYSLHIRREASGVLEHREFLYDDPSRDESLLLAERLVEDLKDCRTLMAHHASVERNILRWLSNRYKDFPELSEQLISFSEIFVDSELLVKNHIYHPDFGGSFSIKKLLPALVEGVGYEGLFIHNGDDARYVFVNMALGNYRESEIEKIRRDMLEYCKMDTLAMVEIHKFLCDLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N9</accession>
    <name>I2F1N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730012.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0093"/>
    <dbReference type="EnsemblBacteria" id="AFK05842">
        <property type="protein sequence ID" value="AFK05842"/>
        <property type="gene ID" value="Theba_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0093"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_0"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="441"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="649" mass="72855" checksum="F054196C2D8F7CD5" modified="2012-07-11" version="1">MKKLKLEDLYKYSAVGDLHIFPGGKNFVFVRKTMNKKENQYESNIWLGNMKNEEVRQLTRGGKDGSPVVSPDGKSILFVSKRDKEAKGTGLYLLPLEGGESRLVKTLKGGFSSVSWIDSETVLFMTKHAPGEDPEKIEEDEPPEKKVYEIDRIPFVSNGAGFTENRVGHLYKMKLENGKMEPITAVGGDIESIVLSPERKSVAVITTEDREKRPIWSSLYLLDLQSETAKRIGDDSLSFYHCEWSDDSELFAVATDFKKGFPTNPFIVHVDLESFTLTTLAREMDLYFGNSLNSDVRGVSPNTSMKVVEGKLYSLVTAGSQIKLVSMDKEGKVEEIAVSSGSIDCFDVAGEELLLSEMTTTEPLEIYSLVKGKKKKLTSFNSWMKGIKLSKPEGFEVEASDGQKIEGWIMRPVDFEEGKKYPAVVEIHGGPKTAYGGGYIHEFQTLASEGYAVIYCNPRGSAGYGTDFADIRGHYGERDFEDIMEIVEYVINEYDFVDEERLGVTGGSYGGFMTNWIVGHTDAFKAAVSQRSISSWISFFGTTDIGYFFASDQTGGDFFDNLEGYLRQSPLMSAPNVVTPILFIHSLEDYRCWVPEAMQFFTALRHLGKEAKMVLFPKENHELSRGGLPIHREKRLRAILEWFDSYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P5</accession>
    <name>I2F1P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730018.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0099"/>
    <dbReference type="EnsemblBacteria" id="AFK05848">
        <property type="protein sequence ID" value="AFK05848"/>
        <property type="gene ID" value="Theba_0099"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0099"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056539_0_1_0"/>
    <dbReference type="OrthoDB" id="1179665at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="315" mass="34897" checksum="03A4BD5DC364B601" modified="2012-07-11" version="1">MIDIRKVFLSLRRLLPFLGIALFTVSIYVLVRELSRYTISDIAAKVGEVPASRLVIAVFLTFLTYLNLSFYDLISSRRAGVKLKFTSTALVSFVGYTFSKNIGFTFLSGTSVRFRLYGKWGVAGGKILLIIILNYLTFWLGFFALSGILFTLWPPVLQSAVRVPFGSLKVIGIASAGIYVLYMVVVSFRKRPFRIRGKSFTLPGRSFTLVQTGISILDWLLSAGVFFMLLPPEIGYFEVLGVFLLSQFAGLSSQVPGGLGVFEALTVVILSPSLKPDILVAALIIYRIIFYLVPFIIAVVSFAVNELLYRGSEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R0</accession>
    <name>I2F1R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730029.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0114"/>
    <dbReference type="EnsemblBacteria" id="AFK05863">
        <property type="protein sequence ID" value="AFK05863"/>
        <property type="gene ID" value="Theba_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0114"/>
    <dbReference type="eggNOG" id="ENOG5032Y2U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194452_0_0_0"/>
    <dbReference type="OrthoDB" id="1961566at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="65" mass="7819" checksum="3D5A8C09A6B95B4D" modified="2012-07-11" version="1">MQCEVDRNLEKCNYTYPGCPRKGKCCECIAYHRRNGELPACYFTEEQEKTWDRSIEYFVKVNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S2</accession>
    <name>I2F1S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoesterase or phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730040.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0128"/>
    <dbReference type="EnsemblBacteria" id="AFK05875">
        <property type="protein sequence ID" value="AFK05875"/>
        <property type="gene ID" value="Theba_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0128"/>
    <dbReference type="eggNOG" id="COG4186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092313_3_1_0"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="171" mass="19664" checksum="74037B2B7D40F02F" modified="2012-07-11" version="1">MKVFFISDTHFDHKNIIAYTSRPFPDVETMNQKLIDRWNETVAEGDLVYFLGDFCMRPKQNARRFRRLLNGSIILIKGNHDGKAAIYLEAGFLEVHKRLVIEHPERNDVKILLTHRAQPNPGADIALNIHGHIHDSALSGENYTGRYFNVSVENIGYRPVELRRLLELAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T4</accession>
    <name>I2F1T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730052.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05887">
        <property type="protein sequence ID" value="AFK05887"/>
        <property type="gene ID" value="Theba_0141"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0141"/>
    <dbReference type="eggNOG" id="COG3613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078780_2_1_0"/>
    <dbReference type="OrthoDB" id="1251644at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="249" mass="28976" checksum="ABD4A7528EDFAEF2" modified="2012-07-11" version="1">MQEKKKCFFVCPIGPENSDLRRRSDEILDYVLKPVLERYTVQRADQIASPGMITNDIVHHLIHDDLVIADLTDHNPNVMYELAVRHAYRKPVIQMISRDQVLPFDVGNQRTIFYDIGHPSSTEELKNGLRKVILGIENGENDGLIENPIMNAELLKEMRMGTRNERALAIISERLDQIYHELMVLRDQTMQGFAESRWQEDSKNEQYGSYLRSMERLLEAFFGTKISQKTSGETSRTKLERQKQKQNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F210</accession>
    <name>I2F210_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05963">
        <property type="protein sequence ID" value="AFK05963"/>
        <property type="gene ID" value="Theba_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0229"/>
    <dbReference type="HOGENOM" id="CLU_1523421_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="176" mass="19731" checksum="1A96DEF5DB5D0D5C" modified="2012-07-11" version="1" precursor="true">MYNYPMCSESFASKYLKKFNNVFRLFVLLTALLLLTSGCWFVKKPSEEVELAFERSIITVQEGSSSSTRLIAKNFEKVYVFEIVLEASGGVEITDVESNLDCLTLIAGSHIQSMVIIHGAFPYDEQEEVRKDFFIEIIFSASENGSLSIISNYALDNDLSTVNIETLSPTLEVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F212</accession>
    <name>I2F212_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0231"/>
    <dbReference type="EnsemblBacteria" id="AFK05965">
        <property type="protein sequence ID" value="AFK05965"/>
        <property type="gene ID" value="Theba_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0231"/>
    <dbReference type="eggNOG" id="COG4870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310103_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="265"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="338"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="949" mass="105146" checksum="857606C99BAA468F" modified="2012-07-11" version="1" precursor="true">MNSKSFCLMVLCVVSVVLSGCFGGFLAPLNLEIPDQRILAGEALHLNLKQFVDCKESDDLVFRIVSGVGIICEDVYSYLPALDESGLYEVQISVNDSKDRESSCVFEIMVDPIYCDITLNASPLEGGVISGGGIFQYGDMDTVQATPSQGYSFTGWYEGNDCLASTTTFTFFVERDATLVACFFEEKYHVIREVNGNGSIEISPDKETYSFGEKIVLTAHPSYGWKFSEWVVDGNRFTDESIVVVVDGDKSVCASFEREEFALNISISGNGSVSCSPASSGCVYEYETLVEIMSIPSAGWEFEMWQGDLDGLDNPGKIIMDSEKHVTAVFVKREYLVEVTADPPAGGVVEGGGCYFSGSEVEIVAVPNSGYRFKEWSENGATFSRENKINIIVLRNFELTAHFEVDNAVPVVEKLNGPEGKVEKSKVGFVWNGTDPDGFIERYEYREDGGDWIDIGTKTYFNWSGYSEGPHTFEVRARDNQGAYSETVGWSFVYVPAYTEQGAFKVANSWGTGGWESIPDGFIFITYEAMKQNEVLCFVLDPRDNYEPRAIAVFEISHPLREECKIWVGVGDPANPLKLKSFDDFYYRGGGWPYPANKMVLDITELLPFDENIVFLKVFDGGSMSTGVIGHFSVEVYDNYPSGSPVQVFSAVETPKDTMNGSYVSVSINDVSVSSTSIGCSFASPGLPTSLLLKMKETLGTYEEGVDYNEIIEGHGTGLRPPSEEEWRAIESSWHEIEGFSPQDGLPYLVDHSSSVYFPPIGNQGSEGSCVAFSLGYYTSTFYEARDRNWNLSGAAWEGGFYGAPSDSYQDRIFSPDFVYHQINGGRDTGCSYVDAINLIARLGICSWRRMPYSVSDHTSWPLENAWREAPRYRSRNETVGVVSVEDDEDINALKLYISSGYLISISIDASKYAYLTANDVWNTKNYTNPNTNHANTIVGYDDTFDGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F237</accession>
    <name>I2F237_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491716.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0256"/>
    <dbReference type="EnsemblBacteria" id="AFK05990">
        <property type="protein sequence ID" value="AFK05990"/>
        <property type="gene ID" value="Theba_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0256"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_0"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="313" mass="34671" checksum="49A8AF9F2BDBBD99" modified="2012-07-11" version="1">MGVNLKGKSFLTLLDFTTDEIRYLLDIARQVKVEKRAGTPTSRFAGRTLAIVFEKRSTRTRTAFETSFGEEGGHAVFLSKDDIHLGVKEDLKDTARVLGRMFDAIAFRGFKQETVEVLAQWSGVPVYNGLTDLYHPTQILADFMTIEESLGSLKGRKLVFVGDSRNNMANSLMIGSAKMGLHFVACGPERLHTDPAIVSKCKEIAKQSGATVEVTEDVDSALKDADAVYTDVWASMGEEDKLQERIALLKPYQVNAEMMKKTGKAETIFLHCLPAVKGNEVTEDVFESPASRVFEEAENRKHTIKAVMIATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D2</accession>
    <name>I2F2D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_0356</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491935.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0356"/>
    <dbReference type="EnsemblBacteria" id="AFK06085">
        <property type="protein sequence ID" value="AFK06085"/>
        <property type="gene ID" value="Theba_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0356"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_0_1_0"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="130" mass="14611" checksum="D7CFEE874826ED70" modified="2012-07-11" version="1">MIDRLEEKALIQKAIEAKERSYSPYSKFPVGAALLTEEGRVFVGTNVENSSYGLSMCAERSAIVSAVSNGYRKFRSIAIVSDRKEPTSPCGACRQFMVEFGNFEVILVGEENIKRTTTFELLPMHFEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H9</accession>
    <name>I2F2H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730250.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0404"/>
    <dbReference type="EnsemblBacteria" id="AFK06132">
        <property type="protein sequence ID" value="AFK06132"/>
        <property type="gene ID" value="Theba_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0404"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021649_0_0_0"/>
    <dbReference type="OrthoDB" id="1597053at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="271" mass="31265" checksum="2C44ECC07EDC7C63" modified="2012-07-11" version="1">MIRRLQKCDGERVREIVKTIWEGDDYIPHVFEKWVEDPSCHFMGLWKDGTLVGIDNLRLLSDKVGWMEGMRIDPALQGKGFGKELGKQTLAIAKRIGLERLYFATYFDNTASIRMNEAFGFNRIGVFTNLESEVGDISDSSFAFNVDSEIPEILDHVSEDWAFLPKEIPDKARFLIQPTRIHDGDNWAVLSKNSKSESCVDINYISIVEERKARSFVHGLKCYAQSKGFERVHTMVREDLDLEPFLYNGFKPFERVRDVFLYFADSSVLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J3</accession>
    <name>I2F2J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VanZ like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730261.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0418"/>
    <dbReference type="EnsemblBacteria" id="AFK06146">
        <property type="protein sequence ID" value="AFK06146"/>
        <property type="gene ID" value="Theba_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0418"/>
    <dbReference type="HOGENOM" id="CLU_2118145_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="114" mass="13079" checksum="87755A91C1050CD7" modified="2012-07-11" version="1" precursor="true">MALAAAIYMVFTVYFYLKPVVPAIEVGSDKFLHFVGFFAGGFLFVILSREEFSKAFRKTFFSFLIVGPVILEFLQVLSPNRQFDILDMVFNYLGWTVPVVIFTFIVRLRTLSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S5</accession>
    <name>I2F2S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730335.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0502"/>
    <dbReference type="EnsemblBacteria" id="AFK06228">
        <property type="protein sequence ID" value="AFK06228"/>
        <property type="gene ID" value="Theba_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0502"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="425" mass="49019" checksum="FC914F48453FDB72" modified="2012-07-11" version="1" precursor="true">MNRRLVFVLLMVLLSLSILVANTIELEFWTHEDPNRTPLEERFIEEFQKMYPNVVIKRVTQSSSKIQELILTAFAANQGPDIFNMSIEDEFAYIANGRVAPVDYEAAGYKDMEDLLASFLPGTLDPVKYEGEIYGLPLEITNWCILLNKKVFRDAGLDPEIDYPKTWEEMMEVSEKLTIREGEIITRRGFDFRYPYYLVAFMPLVEQMGGKLVSDDGKTAIINDEAWLNFLDYMAEWGPNGRNLGSPTYKNARSLFNMDNNDIGMCTTGLYQLARIKADNPEFYDSGEFMVVPFPQFEDAVNYVPAHYYGHYYMVNSQKPKENQEMAWKFISYMLSHAEEYLEKVAIIIPTNELLESETFKNYPYSDVFISDLEKSTVVYFSESSAKIQSLIKEAVESVMLSGTSSRDALDTLRRKVQEVLDDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2S8</accession>
    <name>I2F2S8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730338.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0505"/>
    <dbReference type="EnsemblBacteria" id="AFK06231">
        <property type="protein sequence ID" value="AFK06231"/>
        <property type="gene ID" value="Theba_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0505"/>
    <dbReference type="eggNOG" id="COG1683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076318_0_1_0"/>
    <dbReference type="OrthoDB" id="1757306at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017087">
        <property type="entry name" value="UCP037004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037004">
        <property type="entry name" value="UCP037004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="190"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="322" mass="37066" checksum="7482D67B34AF39DB" modified="2012-07-11" version="1">MIHSRPQVVVSRCLGFDTCRYNGQMIPSKFVKRLKKYVQYFTVCPEFDIGLGAPRAPVRMVRKSDEIRLIQPLTGNDVTERLTDYSHRFLDGLSGVDGFILKSASPTCGIKDVKVYPGEGKVMSSGRDSGFFGGIVIERFNFLPVEDDGRLSNFIIREHFLTKLFTVSRFRELSNNLTRKGLVDFQSDNKLLFMSYNQKEMRIMGAIVGKMDSRDIREVYDEYSSHFYKTMSTPPRHTSHINVLMHGLGYFSKYISSSEKRFFLDTLERYREGKIPLSVPLYILRSYVVAFESEYLARQTFFEPYPEDLVEITDSGKGRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W4</accession>
    <name>I2F2W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492173.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0544"/>
    <dbReference type="EnsemblBacteria" id="AFK06267">
        <property type="protein sequence ID" value="AFK06267"/>
        <property type="gene ID" value="Theba_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0544"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322055_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="549"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="685"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="903" mass="102230" checksum="B985EED13851ED08" modified="2012-07-11" version="1">MLKKTNFEKSSDEVIQRILKKISSEPSSKASLFILEKYRNVFKEVNPDEAFTRTGREIRLSLNPSLKELSEDFSGEMNVVVSSHGKEFREKVFLVSLSYDGEPHGLLIMPAGAESNKSLKDWIKEIELALHYSLKRSAEEEAFRRLKLVSKLTSVLETETQVEELIRKSLEIAREMLRVRWIFYLEGQGKSLHLKAAVGNGNNPLKGIEIEISDDQLSELASEKLFVSARKSDLSSAIFKEDVSVGSFMAIPLAVEGTLNGLIVAADREDIEGEFRAYKHLDKEDLKILDDISRRMAVAISRIRLTKRLELEVRKLRQLGKKHEELINDQKDQLFKLGVLHKITEAMKRSMDRERIVRILLIGATDSSGLRFDRATYFRVDSGRSLLILETQVNSTRGNSFKDRSAYSDLTRYLQDVSLEAAQSTTNNEPSASISYPGNIILERVILRKKMVHVSPEMLRLRGEELSLMNRIIGTDEYLIAPVSGEEEVQGVLVVDNAYSRKKISSGDIEILGLLADSTGVALELTENYKRIVQMAESLEKERNLSNYYRRFVSSILQSLESAIIVCSVDGEITEINRTAGFLLNIEREELIGKKIQSMKPQLGSIIDLLSDAMRIGETITLTDQYFEAFGERYFDVRITPLREEKRKGLTGVILSLDDITRRRNLEQELKGREKLAALGEMSARVAHEIRNPITIIGGFVKRILASSDRKKTEEYAKILMDELQRLDRIVGEVLEVSRRKAKPSKEAFDLVSMTREILAGFEEKAASENVKLVLYTKEERIEYYGNRDKIKQVIINLVQNAIEASESGDEVHVTLEKDSEEIRFSAWNGGKTIPEETLKRIFEPFFTTKTLGTGLGLSICKKIVEEHGGSIHASSGSEGTVFTFRLPTKEFGRFDLEKSTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y4</accession>
    <name>I2F2Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">Theba_0565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730384.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0565"/>
    <dbReference type="EnsemblBacteria" id="AFK06287">
        <property type="protein sequence ID" value="AFK06287"/>
        <property type="gene ID" value="Theba_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0565"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_0"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="28456" checksum="68DDA23CB1512A74" modified="2012-07-11" version="1">MVLLADIGNTTTVLGLTGEKSIEEVWRLPSSRIETEDELFVILDGLLRIKGYSVGEIDGLCVASVVPRLNRTINYFTRKYLPKPAVFLRPDRFFPLGLNTDNPAEIGADRLADVLGAKECYGNNVIVVDAGTAITIDIVKDGNFVGGAILPGPGTAMSALFSHTAKLPEVELFFEDHYFGTNTEDNLRIGIVNGTYFAIQGIIDNIIEKFEEKPTVVGTGGNIDLFLIEGGLIEIADPNLTLKGLSFYYNSVKPFEEDTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y8</accession>
    <name>I2F2Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methenyl tetrahydrofolate cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730386.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0572"/>
    <dbReference type="EnsemblBacteria" id="AFK06291">
        <property type="protein sequence ID" value="AFK06291"/>
        <property type="gene ID" value="Theba_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0572"/>
    <dbReference type="eggNOG" id="COG3404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088419_1_0_0"/>
    <dbReference type="OrthoDB" id="1965647at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FTCD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="23059" checksum="D618F6B39F45BD30" modified="2012-07-11" version="1" precursor="true">MDFCTLSLKDFLKKVAEKSATPGGGAVGAVVAALAASLGSMVANLTIGKKGYEDVEGHMESCLEVFESESNYLCDLMNRDIQAFDQVLSAYKLPKATDDEKNAREMKIQQALKTAIEVPFDLARRCKNIIVNVERLAKWGNSSVLSDAESAAHLLLAVHRIAKANVMINMKSLKDPDYGAWINEEMKQLEKQIDFSYNKIIEIIGKRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F305</accession>
    <name>I2F305_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730396.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0589"/>
    <dbReference type="EnsemblBacteria" id="AFK06308">
        <property type="protein sequence ID" value="AFK06308"/>
        <property type="gene ID" value="Theba_0589"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0589"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933203_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="127"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="298" mass="33324" checksum="35DEB2114B7750CC" modified="2012-07-11" version="1">MRAAKRGIDEGLYIARALLEGNVEACAIVSSEGKIVVANSTWERLAAACFDELSFLSEEFDMKRFSDMLDEVCALRLKEFLSGKTKQVSFALNDFENSKGLPFTIVIYSVEISERLCYFISLRDNSESTVLRNILRDIIYIDPLSGFGNERSLNRFLSKKISSSKENGACFSIVCTMLSNSKEIAAMFGKRILDTVLQRLGKRITLQIEEGKSFRIMDDVYVTVLDCSDRSCVSRTMSVLTSDLEKPVAVSDTDVSPSVVSGICQFPIDGERSESLLSNCLTAIFTAQRKGLKWEFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F334</accession>
    <name>I2F334_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730415.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0619"/>
    <dbReference type="EnsemblBacteria" id="AFK06337">
        <property type="protein sequence ID" value="AFK06337"/>
        <property type="gene ID" value="Theba_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0619"/>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020626_2_1_0"/>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="125"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="503" mass="58313" checksum="DB7FAE13EA04B474" modified="2012-07-11" version="1">MAKINSIRSKYFNEGKRIVEIARETKTDVKTVKKYILKDDFNIQPPQTKKTVKSKLDPFKEEIDCWLEQDKLERRKQRHTALRVFKRLQEKHGGSFDCSYRLVATYVAQKRKELYGQNKEFYFALEHKPGEAQVDFGEADFLENGVRCHGYTLNVSFPYSNGGYLQLFKGENQQCLMEGLMNVFNHIGGVPNRIWFDNASSMVSKILKEVDRILSEHFLRFKNHYGFEAVFCNPQSGNEKGSVESKVGYHRRNLLVPVPEINDLMAFNKELLARCDHDMERPHYSKPGMIRERFEEDRTKLLTLAPNKYDESILLAVRTDAHAKFTLEKGRHTYSSAPQYAKTEIWARLTAHEVIVMDRDYKEIITHPRLYGQMKRESMNWIPYLTQLSRRPAALKYTGIYGLFPSPLQEFLEQSDRSSKKETLKILAELSEDKGFLSAVEAFLAALERGAKDSDSVLAIFRRLNTESFEFSPVLLPNDVPELPPLKNKTLDYDLFLGRSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F346</accession>
    <name>I2F346_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730426.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0631"/>
    <dbReference type="EnsemblBacteria" id="AFK06349">
        <property type="protein sequence ID" value="AFK06349"/>
        <property type="gene ID" value="Theba_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0631"/>
    <dbReference type="eggNOG" id="ENOG5032B2N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080998_0_0_0"/>
    <dbReference type="OrthoDB" id="1732155at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="257" mass="29625" checksum="2C76A97D45D734CC" modified="2012-07-11" version="1" precursor="true">MTARDVLTILGAYARSFGESLVDKPTINKSILSNNIKFYKTLKWINILASFLLFVPVFGSIRDFNLPHMVGYLIMASFGYSTWIFQGITGVPIYEETRFLTLLHLTLHSFFGIWLEFYNNFPLFDGFLHCFGGFWGGFSLFPFIFGSAIAWSNLPPKAVAWKVWLSGMSIVNMIGVFWEIGEFISDKIFGGYPGYRMAQESLDDTMLDLIFNNFGATIGILLFWWYLKRSKDINTFVRDMGNKLGEFFVKEKELLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F392</accession>
    <name>I2F392_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">Theba_0678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492346.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0678"/>
    <dbReference type="EnsemblBacteria" id="AFK06395">
        <property type="protein sequence ID" value="AFK06395"/>
        <property type="gene ID" value="Theba_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0678"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_0"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="227" mass="25475" checksum="3C1903DF2797D9BC" modified="2012-07-11" version="1">MAQADVVNIAGQKVGTVELSESVFNVEPNEDLMFRYVNMQLSGRRAGLASAKTRSEVRGGGRKPWAQKHTGRARVGSTRSPLWRHGGVIHGPKPKDWSMKLTKKMKKVALRSALSLRLKEGNLIVLDDLKFDRPKTKQLREVLNNLGLDKTQKTLFVLPWQKDEYQNVRLSGKNIYGVKVIIADNPGNKAVNSKENIDGLNVYDIVNHEKLVITADLVRKIEEVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A7</accession>
    <name>I2F3A7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="9" type="ORF">Theba_0693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730472.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0693"/>
    <dbReference type="EnsemblBacteria" id="AFK06410">
        <property type="protein sequence ID" value="AFK06410"/>
        <property type="gene ID" value="Theba_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0693"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_0"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="13634" checksum="BBB1BFF535D6885A" modified="2012-07-11" version="1">MFKHKDKKEQRRKRHLRVRSTVSGTPERPRLAVFRSEKHIYAQLIDDSKGITLVSASTVDKDVKASIEKSWNVDAAKKVGELLAKKAKDKGISSVVFDRGGFKFHGRIKSLAEGARAGGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D2</accession>
    <name>I2F3D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730493.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0718"/>
    <dbReference type="EnsemblBacteria" id="AFK06435">
        <property type="protein sequence ID" value="AFK06435"/>
        <property type="gene ID" value="Theba_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0718"/>
    <dbReference type="eggNOG" id="ENOG5034888">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1775246_0_0_0"/>
    <dbReference type="OrthoDB" id="2043358at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="16161" checksum="3A222710D8BEA8DE" modified="2012-07-11" version="1" precursor="true">MEKYVMVIVIAIFLIVTGGVILTFLLEPVEIADVAASRIKIDPINTDRVVSSVSLENHFLPLYASPSEVISSMLEVGEEAEGVRYVAYYRLNKIDYAVLESGQSQVTVRVGEQVAPSYIVYGITEFAVLLNDTSTNSFVVVKYFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E3</accession>
    <name>I2F3E3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">Theba_0729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730504.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0729"/>
    <dbReference type="EnsemblBacteria" id="AFK06446">
        <property type="protein sequence ID" value="AFK06446"/>
        <property type="gene ID" value="Theba_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0729"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_0"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="207" mass="24130" checksum="6C60F5BA88300DD2" modified="2012-07-11" version="1">MKGIVFVMSGPSGAGKTSILREVLRSNNNLDFSVSYATRERRPEEVQGKDYFFVTPEEFKRLQKEDEFLEWAKVHGNYYGTSRHQVSKSVDLGRDILLDVDIQGAMSLMSKLRDAVYIFVAPPSYEELISRLQSRGTEDTQSLRTRLEDAKWELEQVKNFQYLVINDNLKHSVSQFEAIITAERLRVDRMVREKGERFLFEEKTYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J8</accession>
    <name>I2F3J8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">Theba_0787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492482.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0787"/>
    <dbReference type="EnsemblBacteria" id="AFK06501">
        <property type="protein sequence ID" value="AFK06501"/>
        <property type="gene ID" value="Theba_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0787"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_0"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="69" mass="8024" checksum="5FD58993891A298D" modified="2012-07-11" version="1">MKKEMHPEMKLVTVKCTCGAEHKFYSTKENIKIDLCSSCHPFFRGDASSMILDTEGRVQKFRNKYGDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L0</accession>
    <name>I2F3L0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0799"/>
    <dbReference type="EnsemblBacteria" id="AFK06513">
        <property type="protein sequence ID" value="AFK06513"/>
        <property type="gene ID" value="Theba_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0799"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="80" mass="9536" checksum="FE49BD2E27D6CDD4" modified="2012-07-11" version="1" precursor="true">MKKILLFLIDFYRKKISPRTRPRCRFSPTCSTYTYEAIERFGALKGLILGIWRIIRCNSFNPGGFDEVPDHFTLLRRHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M8</accession>
    <name>I2F3M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492517.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0817"/>
    <dbReference type="EnsemblBacteria" id="AFK06531">
        <property type="protein sequence ID" value="AFK06531"/>
        <property type="gene ID" value="Theba_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0817"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="215"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="442" mass="51002" checksum="7D0BCAD2FD90DB90" modified="2012-07-11" version="1" precursor="true">MPYSRRSKKYWKETWKAYLFLLPSIIILGVFVFWPIGFSLVLSFFKWDYTSTTRYFIGFDNYKELFRLTYPVSLSFVNSLMNTVVYVVIVLVVVQLIYYLLGLMSKYDKTDKSHSFLYVIFIALLSGYVLLRNTSIGLTTIGLFAGLGLMGFGLYVLLRRKSSIQSRRMKSSQWSTLILFIVVYYVFAYQILTQSADFVQYFTLAKESSDFLKSIYNTVYYVLLSVPTQIALALIIAMLLNKNIKLRSLFRTAYFIPFVTSVVAVSLVWQWMFNDQFGLLNYILSIFNLPRIAWLKDEVWTIPTIAIVSVWQHVGYTTVIFLAGLQNIDKSYYEAADVDGASGWQKFKFITWPLLSGTTFFIMIITMIGSFKVFSQIFILYQGLPGPVNKSGLTLVYYVFDAFYNQQRMGVASAAAYVLFMIILVLTMVQLNVGKKRVHYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S9</accession>
    <name>I2F3S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0872"/>
    <dbReference type="EnsemblBacteria" id="AFK06582">
        <property type="protein sequence ID" value="AFK06582"/>
        <property type="gene ID" value="Theba_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0872"/>
    <dbReference type="HOGENOM" id="CLU_3027038_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="55" mass="6322" checksum="F8996495BDD67C27" modified="2012-07-11" version="1">MCIVVDFEVESGSFNEKSSLLFGAQELNRKLIQRLPLTHEVSKSLLALWKERDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y1</accession>
    <name>I2F3Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730657.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0928"/>
    <dbReference type="EnsemblBacteria" id="AFK06634">
        <property type="protein sequence ID" value="AFK06634"/>
        <property type="gene ID" value="Theba_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0928"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423237_0_0_0"/>
    <dbReference type="OrthoDB" id="886964at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="466"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="677" mass="74996" checksum="1A99DF2132F99D77" modified="2012-07-11" version="1" precursor="true">MSVVLPIFFALCLLSLLLRNKWSMVLPVTLILGVATIVPILWAIYISFTEYGVFQQAPVFSGLKNFEEVLGDSGFKLSLRLTALWSTLKTSIEILLSFLIALRLRKATKLSKASLILLGVGWFIPSFITVSGWRALVQGYGGYSLFNIVLGTEIDITLNAFQAFTSSLFVSIWLSLPLSTMIILGMLGRVSKELDDVMKIDGTGDIYTSSILFGEIRFLLIPYFFFQLARSMKEFTSVFLMTGNGPLLPEGFTPNTLTGSTTFLGIALFRKFSSVKDYGLLSAYAVFVGGFSLIWILGALFSRGDVPKRHRHVLFLSSAAHVFLGLFTGLNLLLLPVILGYSILPLIIPRFRKTFRLLVGTLLIYEVLITILGVVQRGVSGIVPATLLSVPLILFSLRYRFPIIDFTIPGWLKRTLMVLCLIPTALVVIYILVLSFAADSDIMPSLSEMTLANFGRVISDGLMSNILNTIIIAFWASLILLMAGIPFSYLFSQRKSMLVKGLASIILFGSLYTGMHTLLPMYFVFDKLRLTDSLFGIGIVVCIQSLPLTIILLAEFFSSVPRELREVSLLEGLSGTGYLVKILIPLSLPVIGGLLVYVMVSSFSSFSTPLILLNSQELMPFSLRIFSYVGEVRSYYTSWNLFGAASVIGVVPLLIFFRSSLRLIYSSNLRDQGIEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F432</accession>
    <name>I2F432_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">Theba_0979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730700.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0979"/>
    <dbReference type="EnsemblBacteria" id="AFK06685">
        <property type="protein sequence ID" value="AFK06685"/>
        <property type="gene ID" value="Theba_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0979"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_0"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="315" mass="34813" checksum="C465E62F09F8B7D2" modified="2012-07-11" version="1">MPYQTNEMKVFAGSASLPLAEKISNYLGIRLGDCRTKRFADGEINLKIDETVRGHDVYIIQSTCSPANENLMELLIMIDAFRRASAHSISAVIPYYGYARQDRKARGRDPITAKLVANLLTTSGASRLITIDLHAEQIQGFFDIPVDNLWSFPAFLKFFSQSDFDRNEMAVISPDIGGVKRASKFAAKLGVPLAILDKRRPKDNVAEMVHIIGDVEGKTAIIFDDIIDTGRSLVEAAKMLKSNGADKIFACATHGVFSGDAKKIIAESTIEKVFITDTIYHDDLPDNIMMLSIAPLLAEALTRVRKNLSVSILFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F462</accession>
    <name>I2F462_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730726.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1010"/>
    <dbReference type="EnsemblBacteria" id="AFK06715">
        <property type="protein sequence ID" value="AFK06715"/>
        <property type="gene ID" value="Theba_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1010"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055429_1_0_0"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="388" mass="41792" checksum="2CB1706705C70B92" modified="2012-07-11" version="1" precursor="true">MDTKKAFSLISSYGFFLFGFTSIILGSALPAIEKSFGLDHQIAGVLLSLPTLAFMASAIVVSSLSNRFGPFKLLAAGIVCIAAGLTVLSVGRSFWLLLVGSMTVSFGTGSMETSIGIAVSGLNYKKPGGALNLMHSFFAIGSIISPLIVAAFLVDYTSWWKPFLIALFVSLLLLSFIPFLYGIPFVGSDEKATHFRKEIFSKKIFWLIMVGVLLYVGYEIGFTSWLSSFMFESKGIEMRYASIFPALLWAGIFVGRLLAGIFVDKLGYELSLLMMVIIAFVSFGAALLLQSAIAIALAVVFAGFGFSGTFPTLQAILISSMKNGIGFAIGMFTVAASIGGAMSNFLVGLLGHHFGMMAGVIFILFLIFLEMVVVLLIMRVRKVRVDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F466</accession>
    <name>I2F466_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type uncharacterized transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730730.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1014"/>
    <dbReference type="EnsemblBacteria" id="AFK06719">
        <property type="protein sequence ID" value="AFK06719"/>
        <property type="gene ID" value="Theba_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1014"/>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058196_1_0_0"/>
    <dbReference type="OrthoDB" id="1729219at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="33731" checksum="A7A049FFCF49CCE9" modified="2012-07-11" version="1" precursor="true">MKQVLVCLLLLVGILGLSVQTVGITAIVEHPALDAVREGIIDVLEESGFKDGDNIVIDFQNAQGSVSTAVAIAKQFVSLKAAVMVGIATPSAQALVNASKTIPVVFSAVTDPVSANLVPAFGKNPGNVVGISDMTPVKTQLQLLKLTLPDVERVGVIYNSGEANSVTIREFAKEACDALGLELIDITGSTTAEMVASLNAQIKDVDAIYIGTDNTAASSIESISTVALREKVAIVAGDIDIARSGGLIGFGFNYYQVGRATGELVVEILKGTPPSELETKILGQDSLILFVNTDIAEEIGVEIPQSVLDLANLIVTDGVETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F480</accession>
    <name>I2F480_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1028"/>
    <dbReference type="EnsemblBacteria" id="AFK06733">
        <property type="protein sequence ID" value="AFK06733"/>
        <property type="gene ID" value="Theba_1028"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1028"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810875_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="129"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="342" mass="36169" checksum="95F2E82B7695FB31" modified="2012-07-11" version="1">MSSRRACPENYLFRDPYGISLFKALSVSTAENGGRSTDNRFYVSGIFSVAIGVANKSRPRFCALSRKIGKFSSSKQEFTKTLFAGAREIVYTIPGRGNMNELTAVATGTLGVSPMISPIVTTSVTYGSAFLGGLLSFFSPCILPLIPVFFGVLMGGAADAKARFIRGVFFTLGMSIFFFILGIGATGLGTFIRQNEVLMNVISGGLFVLFAFLYLFEIGMKGVNLNVWKFGGSAVSGFILGAVLGLVWVPCAGPILGSILVLAANQSAVAEGGLMLLVYSLGLSIPFLTLSGLVAKLTSKLSFGGESKWRKVIRVSVFVVLLAAGLLTMTGNLNLLQFATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F486</accession>
    <name>I2F486_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1034"/>
    <dbReference type="EnsemblBacteria" id="AFK06739">
        <property type="protein sequence ID" value="AFK06739"/>
        <property type="gene ID" value="Theba_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1034"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004541_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1438" mass="162310" checksum="A7CDFAA0EDA73D81" modified="2012-07-11" version="1" precursor="true">MGSIFVGLAGFIIFVSLELLYYLSDMIIRYKVGIDKLFLLIYYNLPEFIVLGIPVGILLAIFWVLSRMRSDNELIALQTHGISLKRLVIPFLLIGIIFSGFAYLLNDYLVPAASTKANEAMARFVYKQPEVTLKENVFMQDSQGRMIYVRRIDQDTKELKNVSIYEVSRGQVTLTTAESAVISSNKWILSKANIYQTDESGFLGVEMQFGTAEFEIDEDIERYLASFKSPKEKTSKELRDDIEAFKNTGINTSSLEVALQEKYSMSIAPLVIVLLGVPVSLMFNLQSKSWSVILTFLLVVIYQGSGAWLSGMGKENLINPSLAPWIPNITFSILGVIIYSLIDTKASYRLSELFTRIMKVSAIVLLLLVPGLLEGSNVKIVGGTIAGTKSGREILLGGGVKVEYFSETMNATIEASNASILNVDSTPESISFWGNVKMLSDETTILSDRLILDLTNERVESMQVYSRTELEVPAARGDTSKTGSKVPFYVFGDYVQSTMEASPTFNIGEGYVTTCDKTHPHYRFRVSSAVVTPGKGMSVQNMLMYIGNVPVFYLPAYYFPLDDPERRPFDVDLSGITEAKTRITLRYLELDWLLLQGTWYRDWISTEDAFTAKSVLYTPLGDLELFGQFGQQKETSYGAYVLLKPAFDWLRIQGGALYLSGPSLKELQTPFSGINLGETISKNKVTQLDPFAVKESMNATEMQLAYVQLLSPQDWEPELDVIGAFARYDDENLWMVNLQNLTVPSDGSIDAGFFKLSTSEFNVNGLFGQRYVNNKVLYSLRTKASVLKTESSLFGADASVDSLNFTLASNAATVTELFDPSNMEDFVLEVNKYLFTAGNLKIGGDIKSTFDASTTELNIIMPSDNKGIGRNYLTYASDDGKLKVNGRYALDFDSLHEKNKDKLFWIDPFDILYDGFVSVELKFYFESRYDKSFKIEGKKLRVYKDIELYKGEWGLLSVDVILEPAYEAGFIYDSEEGWELTKNEIPVTLKNEVTFRPFDWYYVGLQYNPVLTYDFINREWRLDHPGKLLTGIDTEIFKADYALELDYEELVASPTEMNWLGKGILTTEAEFALWEVTLGQKTETVFMPVTSQASETSYSVTFDSEVFSHSTKSKVYWQTGDKLDDFVNKERLTIKVATETSFEFTLDWTFDASPSVADDERMLKDLVFGSSIRVKDFAELGVKFRYPYLFGSRKIYDRLKIEVNDLSIGDVSWKNASIDFTTGFSEFDSKYKYPEKYFTKSETQAQFLLWQSTRLSVFSLSVGEYFIATSTASETGDTAYSFGISNVKLGNKPLLGGTNAKFDEFGLSMELRKSEDLYFTMHINELYFPMGSISDTPGVLNRLSLGIDGSGKRSFVEIGTYAGDISMWDESIAKVSPMYFDLHCMALELILRLSFGSDVTTIQDTVESIALKYYIKELKDRYFVIGLYKGAPFFRFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F491</accession>
    <name>I2F491_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative S-layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730750.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1039"/>
    <dbReference type="EnsemblBacteria" id="AFK06744">
        <property type="protein sequence ID" value="AFK06744"/>
        <property type="gene ID" value="Theba_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1039"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470749_0_0_0"/>
    <dbReference type="OrthoDB" id="554219at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658514" evidence="2">
        <location>
            <begin position="23"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="579" mass="63010" checksum="664D35CD4CC99307" modified="2012-07-11" version="1" precursor="true">MKMKVLLASLLILGLAFTSAFAAVNYVDVSSNHWAYDAVMKLSDLGILTGIVQADGKTYFNGNDALTRYQTAVMLKKTLDYVELNFARQGTVPQNGAVDGTVMSRLEALELALTDSTGRLIDTMDLQLRITALENRISSLGISTNGSVSQSTVESLRQQIMKFVEDLSLTTKKLDMLALDVQNVQNSMSDLTVMESKVNDAVRRVDTLSGNVSMIQSSISSNERAISTLDSTVRSLSSSLSDYDAKLSTIINRASANAIEIASIKESMTTLSGDVLSVRDLQNKISSLEDQIANVKLPTEAIDKLDYLSARVNAISSDYAKIGDLQNYVTKTDLKANLNLYAGIDELAQVKNSSEVLYKDLQTLRDDFASETGIIKSDIGNLQRSINAINEIVTIHENELASLKSSVSTVSTLRSDLNALNSKFNALTDQQSKNFAATQASIGDLEARINENMDMLNVTVDASLSRISLGMDTVNTQLGKNESEIKALKTRADSLESRLNTTVVNLERYLKISDLETQPVIVNLSERVAEINKATVDAATKQDVEALQKKTSPWLILSTVSSLAALGISIWVLIDSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D9</accession>
    <name>I2F4D9_9BACT</name>
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        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730790.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1087"/>
    <dbReference type="EnsemblBacteria" id="AFK06792">
        <property type="protein sequence ID" value="AFK06792"/>
        <property type="gene ID" value="Theba_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1087"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="30006" checksum="BF653E5DCC1EA9A9" modified="2012-07-11" version="1" precursor="true">MRAAQFLRRLLRSKQAAVGLFVILAILVLALFSPLIATHEVEDMDFMHIFALPGEGGHLFGTDDYGRDLFSRLVYGSRVSLMVGIVAVGIGSLLGTVIGVIAGFFGGLVDSIIMRIMDALLSFPYVLLAIAMMAVLGPGLFNAMLAIGIVMIPSFSRVVRSAVLTYRNEEFVTAARLMGGSNLWVIMFHILPNIIPTIIIYASLNFAGAIISEATLSFLGLGIQPPTPSWGSMLSEAKNYLQTAPNMAIFPGIAILVSCLGFNLLGDGLRDVLDPRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4I4</accession>
    <name>I2F4I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730829.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1133"/>
    <dbReference type="EnsemblBacteria" id="AFK06837">
        <property type="protein sequence ID" value="AFK06837"/>
        <property type="gene ID" value="Theba_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1133"/>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067323_0_0_0"/>
    <dbReference type="OrthoDB" id="798280at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="35311" checksum="EE113FDE800DB0FA" modified="2012-07-11" version="1">MNKAASVKARLRNLARKQGRSYQDLLQIYALERTIYRLSLSPHKDKFTLKGGIFLYALFEGRFPRSTTDIDLLAQRISNEKESLEKVFYDIFSVDTDDGMRFDLESMNLRTIADAKQYPGTRITITAYIERTRLSVTVDVGFGDCITPERVQMEFPVLLNDPEPVVFAYSKESVIAEKLEAIASLGFLTSRYKDFYDIFLLSRFFPFNGTTLQAAIGETFRNRGTPMEEIVAFEKQFISDSLHKRRWAAFAKKKNTTFDTSLEEVISQIKSFLIPVLEALQRDEIFASYWEPDDLSWKFRRVGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N6</accession>
    <name>I2F4N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730877.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1191"/>
    <dbReference type="EnsemblBacteria" id="AFK06889">
        <property type="protein sequence ID" value="AFK06889"/>
        <property type="gene ID" value="Theba_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1191"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_0"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="115" mass="13205" checksum="66B1417BA44FDBE2" modified="2012-07-11" version="1">MSKRETTEILEDIVDSIDRITAYADNMSYDEFMSDLKTQDAVIRNIEIIGEAAKQLPYSFTLAHSDIPWRAIAGTRDRLIHDYSGVNYDIVWAVIVSDLPSLRARIREILQTEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R3</accession>
    <name>I2F4R3_9BACT</name>
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        <submittedName>
            <fullName evidence="5">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1222"/>
    <dbReference type="EnsemblBacteria" id="AFK06916">
        <property type="protein sequence ID" value="AFK06916"/>
        <property type="gene ID" value="Theba_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1222"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025182_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="484"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="613" mass="69659" checksum="9F5E8A4E140DD802" modified="2012-07-11" version="1" precursor="true">MEARTLGLVMLSIAWWSLFYALELFSDDLESMRLLNKISYPGIVSVSVFYFLFSMALVDKRDWFDWKKIVMLFIVPIAVLFAVWTNEQHWLFYSVSELDQTSAFPLQKLVHGPLFWVAMSYNYLLLLSGIAAVFRKYLRSTGLYKGQLRTVLLGTVFPILVNINYLFDFVDIGYLDLTPFAFTFAGVFAAAGVFRYRLFDIRPVARETVIERLPDGIVILDDGGRIVDLNPMACKMLGIDASDAIGNSVQEVFSDIESLASFFTSGSERRELNARERVIEIKQSPIYSNKGKIRGHIALLTDITERKEVEDALRQSEERLALAVKGGKIGLWDLKMKKGEFSINDRYYQIMGYPAGGSVITFQQWKELVHPEDLLPCLEEMDNCYEGQTDYFDIEYRMLSKGGEWIWVHDRGEAAERDEDGRATRILGTHIDISPTKQIEEALRESQMMYKKLATTDMLTGVMNRYSLTELLKLETERSRRYSAPLSLIMFDLDNLKTVNDNFGHLAGDDALKVTCSFVQSNIRSCDDIGRWGGDEFLIVATNTDLEGAVKMAEKLRSGLSSIDKKEYGPLTISIGVTTLLENESDFDGLLRRADEALYESKRSGKNRVTSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R5</accession>
    <name>I2F4R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730904.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1224"/>
    <dbReference type="EnsemblBacteria" id="AFK06918">
        <property type="protein sequence ID" value="AFK06918"/>
        <property type="gene ID" value="Theba_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1224"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_4_2_0"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="410" mass="45665" checksum="3A86143525AF75B0" modified="2012-07-11" version="1">MIDLIMIGAGNRGYFAYGEAVLSLDGARVVAVAEPDEFRRERFAKDHSIISQNAVADWKSLLSRPKFADGVIVASPETVHVEPAIEALRSGYAVLLEKPVSADLNGIRHLISSGANTSRLFLAHVLRYSGFFKMIKSLLESEAIGKLIAVEYTEQVGYYHFAHSYVRGNWRRSELAGPSILSKSCHDMDILTWLLSSRALSVVSHGGLKYFRRENAPESSTERCLDCPLKETCPYSAVTQYLSDNTYWPVNTIGNDMSFEKRRDVLRTGNYGKCVFRSDNNVADYQNVLVSFENGVEASFSMNAFTSSKTRKIFISGSNGEISGDFDSDRVEVRLFSGKTRTYEISHDGSRHGGGDMEITRDFVRYLKGETGGLSTSFKDSIQSHLMCWAAEKSRLEGGLKIDPWSFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4R7</accession>
    <name>I2F4R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486564.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06920">
        <property type="protein sequence ID" value="AFK06920"/>
        <property type="gene ID" value="Theba_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1231"/>
    <dbReference type="eggNOG" id="COG2359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168904_1_0_0"/>
    <dbReference type="OrthoDB" id="1985350at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007347">
        <property type="entry name" value="SpoVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35331">
        <property type="entry name" value="PTHR35331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04232">
        <property type="entry name" value="SpoVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="87" mass="9007" checksum="2B61868F4AE9D906" modified="2012-07-11" version="1">MEVLKVATHSKPNAVAGALAGVLREKGVAEIQAIGAGAVNQAVKAIAIARGYVAPSGMDLVCVPTFSDVDIDGEVRTAVRFYVQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T7</accession>
    <name>I2F4T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730921.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1252"/>
    <dbReference type="EnsemblBacteria" id="AFK06940">
        <property type="protein sequence ID" value="AFK06940"/>
        <property type="gene ID" value="Theba_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1252"/>
    <dbReference type="eggNOG" id="ENOG503315M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2286677_0_0_0"/>
    <dbReference type="OrthoDB" id="1986938at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="104" mass="11511" checksum="453DA77EE056C1D4" modified="2012-07-11" version="1">MSVIKGQWVQVRRIILAAGERAPSVPEDTKEVPLELRVKGFLLEEKSEVGELVTIETASGRKVSGKLEAVEPAHEHNFGDYIPELSEAGNELTRWLTGGDNDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z0</accession>
    <name>I2F4Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730965.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1305"/>
    <dbReference type="EnsemblBacteria" id="AFK06993">
        <property type="protein sequence ID" value="AFK06993"/>
        <property type="gene ID" value="Theba_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1305"/>
    <dbReference type="eggNOG" id="COG1578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071520_0_0_0"/>
    <dbReference type="OrthoDB" id="1714760at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014444">
        <property type="entry name" value="PH1575-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006593">
        <property type="entry name" value="UCP006593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="31437" checksum="3745EAEEC802528D" modified="2012-07-11" version="1">MKIDLRCIPCNLNSLLRILDQNHAGEEEKKQVVRTFMKEVAEMDWSDTPIDIGRKVGEALEPLFGDSDAFRDIKKMSNDNLLEIYDDLKTELLKLDDPLIGALKLSVAGNIIDVAPGHKIDIHSTMKDALSRPFAIDDLQELADRIRKANSLLIIGDNCGEAVLDKLLLDIAKVPNSYFSVRTKPALNDITMKEALEIGMDEVATLMDSGADAPGAQEKTMKREFSEVYFSADVVISKGQGNLEGLSSVKREIFFLLMAKCEVIGGFLGVPKGSFVAYKKAESRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z4</accession>
    <name>I2F4Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730969.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1309"/>
    <dbReference type="EnsemblBacteria" id="AFK06997">
        <property type="protein sequence ID" value="AFK06997"/>
        <property type="gene ID" value="Theba_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1309"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068890_1_2_0"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="178" mass="20135" checksum="542D9806007D8F54" modified="2012-07-11" version="1">MKSIVVYFSYDESTKALAEAMASSIGADLLRLVPTGEFTRTYYHHVENPEQIETTPGYDPDKEHIWGSESVTMNNSPELEPYSFDPNMYDFIVLGSPVWALTYAPPINTFLQENKIQGKKIALFCTHEGMIGGALENLKKALKGNEVVQESDFESPSSRLEEYIETAKEWVREVKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F531</accession>
    <name>I2F531_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnfE</name>
        <name evidence="8" type="ORF">Theba_1346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486765.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1346"/>
    <dbReference type="EnsemblBacteria" id="AFK07034">
        <property type="protein sequence ID" value="AFK07034"/>
        <property type="gene ID" value="Theba_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1346"/>
    <dbReference type="eggNOG" id="COG4660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046659_1_1_0"/>
    <dbReference type="OrthoDB" id="1782047at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30586:SF0">
        <property type="entry name" value="PTHR30586:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="204" mass="22065" checksum="B27CF4A0FC2F3166" modified="2012-07-11" version="1">MMAESKFKILANGILKQNPTFIQVLGMCPTLATTTSAENGLGMGLATTAVLALSNITISLVRKFIPDKIRIPSYIVIIASFVTVIDMLMHGFVYDLWKTLGLFIPLIVVNCIILGRAEAFASKNDVFSSFLDGLGMGLGFTASLVLLGSVREFLGNGSIFGYHLSDVKMFAMILPPGAFIALGMLAAFFNYLGIRRSKVKKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F532</accession>
    <name>I2F532_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnfA</name>
        <name evidence="9" type="ORF">Theba_1347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486766.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1347"/>
    <dbReference type="EnsemblBacteria" id="AFK07035">
        <property type="protein sequence ID" value="AFK07035"/>
        <property type="gene ID" value="Theba_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1347"/>
    <dbReference type="eggNOG" id="COG4657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095255_1_0_0"/>
    <dbReference type="OrthoDB" id="1814639at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="193" mass="20829" checksum="B0A29EE7A663E4D3" modified="2012-07-11" version="1" precursor="true">MATRLVFIFLSAILINNFVLSRFLGICPFLGVSRKTDTAVGMSIAVTFVMILASIITWILNIALDALGLPFLRTIVFILVIATLVQFVEIFLKKASPGLYEALGIFLPLITTNCAILGLALLNVQQNYTLVETIVNSAGAGLGFALALILFSTIRERMELSEIPEPFKGTAIALITAGLLSMAFMGFQGLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F559</accession>
    <name>I2F559_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">buk</name>
        <name evidence="10" type="ORF">Theba_1374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731008.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1374"/>
    <dbReference type="EnsemblBacteria" id="AFK07062">
        <property type="protein sequence ID" value="AFK07062"/>
        <property type="gene ID" value="Theba_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1374"/>
    <dbReference type="eggNOG" id="COG3426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048716_0_0_0"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="351" mass="38114" checksum="11EBE53CB99A9A0A" modified="2012-07-11" version="1">MKILAINPGSTSTKIAVFNDEEEIVRGSIQHFSSRNDRSQDIQDRAEEILSFLKESSISFDFDAIACRGGILPPMESGTYLVNDKMVDFLLHRSAIDHPSNLAAPIGLRLSEGKIPVFITDPISVDELCEEARLSGLPQLPRVSRLHALNMKAAARQIAFDLGRDVQNLNLVIAHLGGGISVGLQLRGKMVDVNNATDEGPFSPNRTGELPVGDVVEKCFSGEYSERELLNRYLKFGGLLAYLGTDDLRKALEFAKEDDDAALVVDAMAYQIGKEIGGMVAVAGGSIDAIVLTGGMAYNTEFVQKIKEYIGKFALVVIEPGENELLSLALGAKRVLEGTEKARTFDPEVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5B8</accession>
    <name>I2F5B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoheptose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731065.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1435"/>
    <dbReference type="EnsemblBacteria" id="AFK07121">
        <property type="protein sequence ID" value="AFK07121"/>
        <property type="gene ID" value="Theba_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1435"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080999_3_0_0"/>
    <dbReference type="OrthoDB" id="1571626at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="193" mass="21340" checksum="16CDF1F7E46BC215" modified="2012-07-11" version="1">MEFNRVARMAFEESMRVKSEFIDKYEELIYEVARKIARRTGNGGTVYLMGNGGSAADAAHLAAELVGRLYLERSPIRAVSLPSNDSILTEIPNDFGYDQVFSRQLEAFLAEEDIVIAISTSGKSTNILRGLKVAIERRSLRVGLTGKTGGEMPGLCDYLFKVDSTDIPRIQETHITLGHVLCQLIEAITVGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I3</accession>
    <name>I2F5I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mgsA</name>
        <name evidence="4" type="ORF">Theba_1504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1504"/>
    <dbReference type="EnsemblBacteria" id="AFK07186">
        <property type="protein sequence ID" value="AFK07186"/>
        <property type="gene ID" value="Theba_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1504"/>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120420_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="135" mass="14997" checksum="08E48CE8CEC2AFD8" modified="2012-07-11" version="1">MSEKPRIALIAHDKKKIDLIMFVREHVDVFKKCALFATSTTGNILREKVKLELTSFKSGPLGGDLQIGSLVASDEIDFVIFLRDPLTAQPHEPDVSALLRVCDVHNKPLATNLATAEALVMEIRRFLKLSDVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K2</accession>
    <name>I2F5K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine beta-lyase/cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731123.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1529"/>
    <dbReference type="EnsemblBacteria" id="AFK07205">
        <property type="protein sequence ID" value="AFK07205"/>
        <property type="gene ID" value="Theba_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1529"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_0"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="380" mass="41261" checksum="3F8FE9CEE596C10C" modified="2012-07-11" version="1" precursor="true">MRGFNTRAIHAGEEKKINDAVSTPIFQTSNFLADDVKYMDESSEVLYTRVGNPSIGVVERKLSDLFGGTGGVFFSSGMGAITTVFLSILKSGMNLVISRNIYGGTQSLISDLPGMGVEIRRFDQSRIDELETLIDDKTGIVYVESMSNPDLILSDIEGIARITREKEAVLVVDNTFLSPYNFRPLEYGADVDIQSLSKYVNGHSDVIAGFAAFKDSGLEKRVRKVMIKLGTNGAPFDAFLVGRGAKTLGPRMELHNRNAREVAEFLSKNPKVLRVSYPSLKASVPACFSECRGFGGVVYLELESLSAAKSFIRRSELFLEATSLAGVESLATIPVLTSHASLSAEQLRDAGLSEGGVRLSVGIEDLEDLLSDLDFAMKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N9</accession>
    <name>I2F5N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731149.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1570"/>
    <dbReference type="EnsemblBacteria" id="AFK07242">
        <property type="protein sequence ID" value="AFK07242"/>
        <property type="gene ID" value="Theba_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1570"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="222" mass="24736" checksum="2ECAC64E660F9A8A" modified="2012-07-11" version="1" precursor="true">MFELKEVALIYETKKQALAALKSTNLIIEQGEEVGVFGPSGSGKSSLLFIMSTLKEPSRGEVKYEGKEITALTPSAKAELRRKEFGFVFQEHFLINHLTVRENILVPIRDKRGIKRRVEEITTALGLEDLLKRFPYELSVGQSQRVAVARALIGNPKVVFADEPTASLDDENGRKVINLLRSYCSKSGATLVLVSHSAEIIADFKRRIKVENGQVYEDTVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5X4</accession>
    <name>I2F5X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731222.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1665"/>
    <dbReference type="EnsemblBacteria" id="AFK07327">
        <property type="protein sequence ID" value="AFK07327"/>
        <property type="gene ID" value="Theba_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1665"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_10_3_0"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="58"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="189" mass="21324" checksum="1AD2A1872D154BF2" modified="2012-07-11" version="1">MWDALNQIELSVMDSLNAVMSGQFMDLFLSFMLFLERGALVWILLTVFLLLDKKYRRAGYMTSLGLGISLLIAFVIFKPVFGRLRPLEFIEGYTIIFPIPETYSFPSSPVAVAFAYTAVLWNSVKMLRVPLALLSSLIALAEVYVYFSYFSDVIAGALIGIACGILTVWLFDKYTIIKPERNDKSDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F650</accession>
    <name>I2F650_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1680</name>
        <name evidence="3" type="ORF">Theba_1747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1680"/>
    <dbReference type="EnsemblBacteria" id="AFK07340">
        <property type="protein sequence ID" value="AFK07340"/>
        <property type="gene ID" value="Theba_1680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07403">
        <property type="protein sequence ID" value="AFK07403"/>
        <property type="gene ID" value="Theba_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1680"/>
    <dbReference type="KEGG" id="mpg:Theba_1747"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1319686_0_0_0"/>
    <dbReference type="OrthoDB" id="791653at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="22900" checksum="6458A7588A9FDDC5" modified="2012-07-11" version="1">MRNGWYTDGEKLSEDLPYTFNTSDWLPTQGVTDTLPIVAWFPPVFYHFNVVANPPEGGEVMESGVFIYGAPMTLGAIPNDNYVFRNWTFEGAEFSDNPLWEGNSTFFLARSTCIGCTEFTIVGNFDLDVPDTITVNLRAEPPEGGEVSGGGKFSKGSSTTISAVPNSGYEFSGWYFDPCGSPFSDSQTLTLSNLQVDWALFASFHKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F659</accession>
    <name>I2F659_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1689</name>
        <name evidence="7" type="ORF">Theba_1756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MesG1.Ag.4.2</strain>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731243.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1689"/>
    <dbReference type="EnsemblBacteria" id="AFK07349">
        <property type="protein sequence ID" value="AFK07349"/>
        <property type="gene ID" value="Theba_1689"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07412">
        <property type="protein sequence ID" value="AFK07412"/>
        <property type="gene ID" value="Theba_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1689"/>
    <dbReference type="KEGG" id="mpg:Theba_1756"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_0_0"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007918975" evidence="4">
        <location>
            <begin position="29"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="74"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Ser)" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="536" mass="59993" checksum="7FFB7A52480670F4" modified="2012-07-11" version="1" precursor="true">MEIQSSRLLRKVLIGATGSALALTSALAANYEDTMPLETVKPAPNLEEVLPHPEQREEAMAKLAEFESRTGKRPNILVYLMDDVGWGDLGVYGGGVAVGAPTPNMDALARDGLMLTSAYSQPSSSPTRATLLTGQLPVRHGILRPTLYNEPGGLTNAVTLAQLLSDAGYVTQAVGKWHMGENPGSQPQNVGFDDFSGFLSVSDLYTEWRDPYFYPEIATSEERTEMIREWAFEKYWVHAEKGGTIEQVKEIDIEVSSHLDEYWKDYSIEFIEKMADSDQPFFLYHCTRGAHFDNYPRDEYEGSSPAKQVYKDTIVELDDILGELVAALERTGQLENTLIFIASDNGPEMESWPDSAYSPFRGAKGSTWEGGVRVPAIFYWKGMIEPGRASDGLFDIADIFNTCLTLAGATDSIPTDRFIDGVDQTSFLLAEEGLSNRKYIYYWLMSYFSAVRVAEYKYVQFAESDSGEGIVNPGGFTGYIMAFPYYHLYNLYLDPKEEHNVSIRKLVFTDLFLEAMKKHIDTFLEYPPVVEIITGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F674</accession>
    <name>I2F674_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1705</name>
        <name evidence="7" type="ORF">Theba_1772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MesG1.Ag.4.2</strain>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731258.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1705"/>
    <dbReference type="EnsemblBacteria" id="AFK07364">
        <property type="protein sequence ID" value="AFK07364"/>
        <property type="gene ID" value="Theba_1705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07427">
        <property type="protein sequence ID" value="AFK07427"/>
        <property type="gene ID" value="Theba_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1705"/>
    <dbReference type="KEGG" id="mpg:Theba_1772"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="288" mass="32840" checksum="A51EEFA62BB22925" modified="2012-07-11" version="1" precursor="true">MFRNNKVAWLFVLPALVFLLVFKIWPIGVSVIESLTMTSYTGTKSFVGFENYEYLFKHDPVFWKSFSVTLLYSIIVNPLIVLTSLLMALLLNSSHFFTKFFRTVFFLPTAISFAVVSVIWMIVLDPYNGLANSFLTMFGFKPQPFFASPDQALWGLILLNVWRSSGYWMMYFLAGLQNIPETLYEAAEIDGASTLRKTFKITLPLLTRTISFVLVANTAFNFLSFAPVYIITKGGPMGSTNLLMYESYKSAFVNLDMGRASAITTILLGIILVFSFFELRFTRARFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F693</accession>
    <name>I2F693_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731277.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1795"/>
    <dbReference type="EnsemblBacteria" id="AFK07446">
        <property type="protein sequence ID" value="AFK07446"/>
        <property type="gene ID" value="Theba_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1795"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141927_0_0_0"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="245" mass="28096" checksum="893319B23687D029" modified="2012-07-11" version="1">MPNLYFYAGSANPELYELQNELIDPERKIEKVMEEFCDFEGSVIVDVGAGSGFHSHMYASTASMVYAVEPDSGMLKQLKARQARDFRSNFCVLKGFAEDLPLKSDLADIVHARLAYFFGPPMKYTESCEEGIEEVKRVLKTGGYFFNIQNNYSSGQYADFLELSYGRDLKNLQKEISDYFASRGFLERIVRTKWRAKNRGEIEKALTLEFPIEKVGQIMKAFSGNEFSHDFSIFFFKKRTRGENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6B4</accession>
    <name>I2F6B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S oxidoreductase, coproporphyrinogen III oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488421.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1816"/>
    <dbReference type="EnsemblBacteria" id="AFK07467">
        <property type="protein sequence ID" value="AFK07467"/>
        <property type="gene ID" value="Theba_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1816"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_3_1_0"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="47173" checksum="21F5B69A337FD528" modified="2012-07-11" version="1">MGLAERVMELGKKLFRIQNVDGSGPMAFDSSPGLYIHVPFCPEFCSFCPYNKIKYDSKLTNKYLTALKRESELQRVGQFSSIYIGGGTPSYDLDLLKGVVSHFREMTDGEIALEIHPADVSSKRLEEIRETGVNFVSLGIQSFDDFTLNSMGRRRQDSVVSLNSIAATTSAGFDFVDVDLIFDYQLERRRIVEDLETAISYGPEQVSVYPMMRFADTAYKNTKNDPEKELEILEELENVALSKGYIRDSLWTFKKRNEGRKYSSVSREFFLGIGTSASSFNGKEFRTNTFSLDEYYSFLDSGKLPVSKTIKMVKFSAILYYSFWALYGGQLDLRRLEEHFGRLPVRMRYLLHSAIARGYFQREEGIVKPTRIGTRKLHIVEEWLTYSFIDRIWSDLRNKARNHSISGESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C7</accession>
    <name>I2F6C7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Shikimate kinase</fullName>
            <shortName evidence="12">SK</shortName>
            <ecNumber evidence="4 12">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aroK</name>
        <name evidence="15" type="ORF">Theba_1829</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="4 12"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731304.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1829"/>
    <dbReference type="EnsemblBacteria" id="AFK07480">
        <property type="protein sequence ID" value="AFK07480"/>
        <property type="gene ID" value="Theba_1829"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1829"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_5_1_0"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="14">
        <location>
            <begin position="209"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK07480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="495" mass="55725" checksum="2F96715F7C9FFE5C" modified="2012-07-11" version="1">MRVFLIGMMGSGKSTIGRILSSVLDKKFIDMDSEIERAKGMSISEIFEKEGEKEFRRLEKNLLKELVRSDEIVVSTGGGVILDNENRQTLKGENSIYLRLPPADLYRRVSVKGRPLLREGKESIFRIWEERRELYEQFPSVDTSSQTQWETVAAISMKIAAGERKTLNSSSHPVSISPGGFKSIGRMPNTVVSKRVQRIFSEWIPSSAFSIDDGEEAKGFHTLFQIYEYLMDRGVSRSDMVVGAGGGTVTDLVGFASSTFKRGVPITLYPTTLLAQVDASIGGKNGLNFEGCKNVVGNFYMPYETIIDPVVTLSMDEGRFEEGLVEAFKIFLITGRWYENFKSRCRDLKNRNLRALSEMLEEAVRQKDRIVAIDTRETGMRRILNLGHTLGHLYEPLAGVSHGMAVAWGLEREMHYFANLGLIDEEMYREVSETLSEIVGLDFPQLPVEDALRLLRNDKKATTSESMEIEIPLVRKPGSFEFAKVRLDDLLAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E8</accession>
    <name>I2F6E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488336.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1851"/>
    <dbReference type="EnsemblBacteria" id="AFK07501">
        <property type="protein sequence ID" value="AFK07501"/>
        <property type="gene ID" value="Theba_1851"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1851"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290661_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="144"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="220"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="615"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="686"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="809"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="857"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="879"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119296" checksum="0284C6AAD2F34473" modified="2012-07-11" version="1">MSTEEGSDNLARSVFALQERMKELDCVYRIFNELHKSSTADEAVVSALEQLPRGFRFPELTAIRIEIDGNEHRSVDQWSDERMISAEIVVNGKKIGTISVSLTEELDIKGSPFLKEEKKLLSGVAVALSNTLERVIIQRELKESLARLTFAVDASGEGIWDWDIETGKVIFSKRWKEILGFSDEEISDHFSEWEKRIHPEDVEEVKSVLNRCLKGDIPFYEKEYRLIGKNGSLVWVRDRARIVSRDSEGKPLRMVGMYTDLTQRRMDEIKLQKLNKLLTLMFRANEFLVHAKDEHSLLKGLCDIVVENGGFPLVWIAFKKSGGKMLTPVAVSGVAKGYPYEVAVAWDNSELSRSAIGKAIKTGRTFISRDIDSSPDYLPWKKTILKYGLKSSIAVPLVIGKEIIGGFVIYSTEEDAFDNEEVLLLEELGEDISYGILSLRLEAQLEHQSGVLSSIRRVNQLIVSATDVEELIKRATELMTGSRGFERCLLVLVENGDVKNWAASGFSRTQLLEVDSIFESGEIPPLLRRTMEEEGVISLTGRKSSKQCVTISDSDDLAVFAKGLRIGGNILGAMAVVMKQSFSFSKDERDLFSEIVDDISFAIHKIRIEKNERVLQKRFSLFMDKLPGAVFISDSDLKTSYFNDFAARVFGFKEDWKGKNPEANYPGELDKLILQDDRRTQNGENIVREERVLGTDGKERILYVQKFPIVSEGDKPMVGAIAMDITEWKLAEMALTRLGRVIDLSVNELYIFDSETLRFLQANKGALENSGYSLEELRKMTPLDLKLEMDKRAFEDILFRLKREPGSYEVFETVHIRKDGSKYPVEVRLQLHDNEYERVFVAIVLDISVRKIAEESVKKSLESLINTLSSLVEARDPYTSGHQKRVSELSTAIARKLFSEDEMHEDIVESIRVAALLHDIGKSAVPTEILTKPVRLNNLEYDLVREHSKKGYDILKEVYFPWPIADIVAQHHERLDGSGYPRGLTGDEIRIEARIIAVADVVEAMSSHRPYRASLGIEAALDEIRQNSGRFYDRRVVEACLELFEEGFQFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J7</accession>
    <name>I2F6J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1902"/>
    <dbReference type="EnsemblBacteria" id="AFK07550">
        <property type="protein sequence ID" value="AFK07550"/>
        <property type="gene ID" value="Theba_1902"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1902"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_0"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="37"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="228" mass="25306" checksum="674B6EB04DDB4E4B" modified="2012-07-11" version="1">MNGRIETYPRLDVFSESSEILLDGNRLIFSSEEKVVYLVNKPIGYLSAMSDDRGRKTLSDLVSDRIKERVFHVGRLDQDSCGLILMTNDGDLSNLVSHPASEIEKTYVVGIKGKLTDRDLEAVKGGLTLGDGFKTSPAKIRLVRSDGDFSKYAITIHEGHKREIREIFRVLNKSVSSLVRVSIGPLSISLVPSPGDIKRLSRKEIALLENGAHRKAPKKAQRKNNFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K2</accession>
    <name>I2F6K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731357.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1907"/>
    <dbReference type="EnsemblBacteria" id="AFK07555">
        <property type="protein sequence ID" value="AFK07555"/>
        <property type="gene ID" value="Theba_1907"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1907"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_6_0_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="48350" checksum="57A40007E36D69F8" modified="2012-07-11" version="1" precursor="true">MKRLILLTLFSCLFVGLFAVELVFWTAPNPLQESFWKEVVAEWNENNPDIQIKWSTIPAAGTSEEAILTSIASGRMPDICTNIFSGFAAQLIEADILIPLNSFPDFWELMEQRKMTSIVENWKFGDNYYVLPIYSNPIMMWWRSDILKELGYDRPPRTYSEIYEISEKYSVPYEKYGALVVMGRNWYDRWYDFITYYYAASEGAPYLDVEKARALFNNETGEKVVTFMDTMFRNNWTAVDLGSNPFYFGVVLGGIFGPWEINQARNLFPDVFDHITIVPPPVPDDYPEDKPIYTFADTKGLVMFATTKHREAAWKFIKWVYSDIEKDRKWMEFTNLPPAREDLLTNPIFQEYMEDNPKFAAYASHVAYAVPPALTTKTVEVQEILTTFLIEQIMYGKSTPLDALKDSATRVRRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q7</accession>
    <name>I2F6Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488110.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1967"/>
    <dbReference type="EnsemblBacteria" id="AFK07610">
        <property type="protein sequence ID" value="AFK07610"/>
        <property type="gene ID" value="Theba_1967"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1967"/>
    <dbReference type="eggNOG" id="ENOG5032E24">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107131_1_0_0"/>
    <dbReference type="OrthoDB" id="1592993at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046272">
        <property type="entry name" value="DUF6305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19823">
        <property type="entry name" value="DUF6305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6305" evidence="1">
        <location>
            <begin position="33"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="195" mass="21174" checksum="26FB96275C481D96" modified="2012-07-11" version="1" precursor="true">MRKIALGFLLLLILAVPCTMLFSEEIEMPVVQPPMVVTTLGQSPGALMFRLVCVRNQIACVQEDLLTVEKLVQLVEGENPPKTLVITTGTSLKGMGAAGIDMNFEVKRVEGLIAKAKELGMTIIGAHIEGMARRVDATDEKSISTVMPKSDLILVIEDSDSDGFFTNFSNETGIPLVKVKESLEIGPALKKLFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T1</accession>
    <name>I2F6T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488063.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1991"/>
    <dbReference type="EnsemblBacteria" id="AFK07634">
        <property type="protein sequence ID" value="AFK07634"/>
        <property type="gene ID" value="Theba_1991"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1991"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064060_1_1_0"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="95"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="217" mass="24569" checksum="AFEB6A798DAEF5E5" modified="2012-07-11" version="1" precursor="true">MNEIRSSFIEALDSQDKKRAVEICIDALDSGSIEVVDLYLEILGPALGNWECDYESDRMCIWNEHIRSSIVRTVMECCYPYIIGKRGGKRSAEKEVTVAVLCPPEEYHEIGARMISDIFTIAGYNSTFVGANTPLDTFLEAMKELNPSYIAISVSNYYNLINTRRMITKIREHGGKSRIVVGGKAFEKNPNYWKEVGADIFLKDPREIFSFGEGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V7</accession>
    <name>I2F6V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like enzyme, predicted cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731443.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2017"/>
    <dbReference type="EnsemblBacteria" id="AFK07660">
        <property type="protein sequence ID" value="AFK07660"/>
        <property type="gene ID" value="Theba_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2017"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044992_0_0_0"/>
    <dbReference type="OrthoDB" id="575975at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="309"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="447" mass="52175" checksum="4953131EAFE82A54" modified="2012-07-11" version="1">MDFLAAQLPEKIGLLESNGDYKGAIKEIDSELESYLPSIMTRRLLWEKERILRLKDNYPYTNSQAFEILSNSIDNFTREEFEGLCEAKQLDSMTLDGEERFERRFDKNLLFVMPEYGSRLKQKDNERDEIRALLHREIDRLISTREPSKFKVNARSSINVQSSEENVFRCWLPVSRNGEQVSSTKILNTSHDYFLSPADYSQRTVYMESDAKKDTVFSVEFEYEISEISTSLDPSRCTHPDEKRFESYLIERAPHIVFSPFMRSLADEISGKETNPYYIAKSFYDWICEHVKYTFMSEYALYPNLSEFAATNLRGDCGVKALLFITLCRIKGIPARWQSGWFASPKGASPHDWALFWLEPFGWVPADCSFGGSRKDIPAYREFYFGNLDAYRMISNSEFMAPLLPAKRFFRSDPYDNQVGEIETEKRALRSYERECSIEILSFERLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6X8</accession>
    <name>I2F6X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731462.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2040"/>
    <dbReference type="EnsemblBacteria" id="AFK07681">
        <property type="protein sequence ID" value="AFK07681"/>
        <property type="gene ID" value="Theba_2040"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2040"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="264" mass="29307" checksum="5F112E0A60409FE9" modified="2012-07-11" version="1">MADALLANNIVKAFKKSRKEIKALKGINLRIKEGEIFGLLGPNGSGKSTFIRIASTLLIPDRGSISIFGYDSVSNSASVQRMINRVSVEASFFRKLSAVENLCFSAGLYGIPRREALKKINGLAERFGLDLKRLKDPLEDFSRGMQQKVAIVRAFMTEPKMLLLDEPTTGLDPRAKRDVQSLISDVKNTMNTTMLLTTHDMDEAEKLCDYVAIIHLGRIVASGRPSELKKQLLGKVDNPSFEDVFLEFTGMSIEEAEYQEVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y5</accession>
    <name>I2F6Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_2047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731468.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2047"/>
    <dbReference type="EnsemblBacteria" id="AFK07688">
        <property type="protein sequence ID" value="AFK07688"/>
        <property type="gene ID" value="Theba_2047"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2047"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="405"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
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        <location>
            <position position="352"/>
        </location>
    </feature>
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            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="443" mass="51513" checksum="1E3BFB3D223E1892" modified="2012-07-11" version="1" precursor="true">MRAVFPEGFLWGVATASYQIEGADFEDGKGPSIWTDFSHRPGKVNSGDNGDVACDHYHRFSEDIELMKQLGVNSYRFSISWSRVLPEGRGKINRKGSDFYNKLIDRLLEVGIQPMVTLYHWDLPLELHRKIDGWESRDMRHYFGDYSSLVFSEFGDRVKHWITLNEPYCSSHVSYLWGEHAPGKRDLKTSLTVAHNLLLSHGEAVRRFREVVKDGTIGLANVSTFVEPATDSKEDRWAARIRDQFINGWFFETPITGEYPSELFKRFNDAGVQPLIEDGDMDLISTPFDFWGVNYYTRNVIRKEESSILGSEVVQGELAKTEMGWEVYPEGLEAFLYKTFKEYGKKPIYITENGMACKDKLTDGFVEDFERVDYMKRHFSSALSALKAGVDLRGFYVWSLLDNFEWSYGYSKRFGLVYVDYEKGLKRIPKRSYYYYRDFLERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z2</accession>
    <name>I2F6Z2_9BACT</name>
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        <submittedName>
            <fullName evidence="6">ATPase component of ABC transporters with duplicated ATPase domain</fullName>
        </submittedName>
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    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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        <property type="gene ID" value="Theba_2055"/>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_tran_Xtn"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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    </dbReference>
    <dbReference type="Pfam" id="PF12848">
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    </dbReference>
    <dbReference type="SMART" id="SM00382">
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
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            <begin position="298"/>
            <end position="511"/>
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        </ligand>
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        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="605" mass="69871" checksum="5B93187975828A09" modified="2012-07-11" version="1">MLITLSKVGHDYGQDFLFDEVSTSIDRKDKTILLGKNGSGKSTLMRIISGDLLPSEGEIFLSTNVRIGYQIQNRIPNSELTLMDYYMQDKSSVLPDTEEYYSFDRRVRSILVGLEFGEEDWERRLETFSGGELTRISLGKLFLVDYDLLLLDEPTNHLDLESTEWLVSFLKNYKGALLVVTHDRYLIRNVGNRFWELNGGSLWDFPGPYDRYQADREIMLKSGLRTRDNLSKEIERLDSVAKRYRLWGQEKFIKQAINKEKQRDRLIEQLESIDLPDEEIRGTKFRLPQPDRTGYSVLKIEKLSFGFGSKNLFSSATTEIHRRDKIGLLGPNGSGKTTLLKIITGNLKGYSGEVTWGHNVRWGYLSQLTEDLNSSNDVLTEIWQLMRGQPDYEVRKYLGRFGFPGDDVFKPIHTLSGGEKTKLALAKLILSRPNVLVMDEPTNNLDIWSIESLEQVLKEYEGCIILVSHDREFVQNICDRFLMIDRHKLKSVSTVDEYLSRNQSYTGSVGNDDGRVSFQERRRLSNKKKSIIEKLQQLDAEEEALSNSLEEIHARMGLYASDYERLQEFLNTLDQAEERILEILEEREILEHDLEELSTMMGDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F703</accession>
    <name>I2F703_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">Theba_2068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2068"/>
    <dbReference type="EnsemblBacteria" id="AFK07706">
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        <property type="gene ID" value="Theba_2068"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2068"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="41"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="149" mass="17788" checksum="D095A60B8EF17F1B" modified="2012-07-11" version="1">MLAIRRGSDLFRPFEEIQREMDRLFNDAFKGLSDQSRETTMFSPEVDIYEKDNSVFIEMDIPGIKKDELEIKVEDDVLSIKGEKKLEREQKERDYHRYERYSGAFQRIFRLPDYVKSDEVKAKYEDGVLKLELPKKEEVKKEAIQVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F722</accession>
    <name>I2F722_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731502.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2091"/>
    <dbReference type="EnsemblBacteria" id="AFK07725">
        <property type="protein sequence ID" value="AFK07725"/>
        <property type="gene ID" value="Theba_2091"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2091"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_17_1_0"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="155"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="387" mass="42159" checksum="32BE5502909F3B85" modified="2012-07-11" version="1">MIEGKEVASAGQLRYGMVGGGEGSFIGDVHRKAIAIDGLAKLVAGCFSIYYDDTVRTAKKLGVSDDRVYKDYKEMARKESEREDGIDFVSICTPNVTHFPIAKEFLEANINVVCEKPLAIDESEAQELADLAKKKNLLFAVAYAYSGYAMVKHAREMIQNGAIGEIRVVMGEYAQDWLATRLEDTGNMQAAWRTDPSQTGKSNCVGDIGSHIENTVSYITGLKLKSLCASLDSFVPGRTLDDNAEILVRFSNGARGVFWASQVAVGHDNGLKVRIFGSKGSIEWEQENPNYLKIAYVGEPVQILSRGGGYMLPNAASVSRIPAGHPEGYYEAFANIYRNFATTLIKKKSGEDMSGADFPTVEDGLAGVRFIGKAVESSQKGSIWVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F727</accession>
    <name>I2F727_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731507.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2096"/>
    <dbReference type="EnsemblBacteria" id="AFK07730">
        <property type="protein sequence ID" value="AFK07730"/>
        <property type="gene ID" value="Theba_2096"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2096"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_0"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="296" mass="31205" checksum="76937FFCAC4D7C40" modified="2012-07-11" version="1" precursor="true">MKRMLLVVLVIGLFALTGFAAKTIGFSVSTLANPFFVTMKEGGEAKASELGLEMIVLDAQDKPETQFAQIQDLITRRVDVLIINPVDSDAIVSAVLEANAAGIPVITVTRPSNGGVVEQHLDIDNKEAGMLAAVALAEALGGEGKVAVLEGIPGAPSAVDRQKGFMDELKKYPGIEVVASLTANYSREEGARVTEDILQGNPVLDGIYAHNDEMALGAVRAVVAAGRLDEIKIVGIDATDDAIAAIKAGEMVATVQQQPYLQMQMAVIAAQRIINGATVEPKVIIPLKLITIDVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F732</accession>
    <name>I2F732_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ribose pyranase</fullName>
            <ecNumber evidence="2">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487866.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2101"/>
    <dbReference type="EnsemblBacteria" id="AFK07735">
        <property type="protein sequence ID" value="AFK07735"/>
        <property type="gene ID" value="Theba_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2101"/>
    <dbReference type="eggNOG" id="COG1869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135498_0_0_0"/>
    <dbReference type="OrthoDB" id="1750843at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="16439" checksum="0C2B4E7CE73B3E82" modified="2012-07-11" version="1">MKTKGILHNDLSREVARLGHGDMLVITDRGFPFPRHGNTVCIDVSVGRNLPRFVDVVKVVLEELEIEKVIIADETRSVSPEIYSQLKEIVSKVKNKGNDIIEENIPHPEFKDLVLNGSLQGKEVKVFVKTGEFTPYANIILVSGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F753</accession>
    <name>I2F753_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="14" type="ORF">Theba_2122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731526.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2122"/>
    <dbReference type="EnsemblBacteria" id="AFK07756">
        <property type="protein sequence ID" value="AFK07756"/>
        <property type="gene ID" value="Theba_2122"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2122"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_0"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="12">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK07756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="462" mass="53725" checksum="06EABB9A9A46950F" modified="2012-07-11" version="1">MEIRLTNTMSRRKEIFKPLKIGEVGIYTCGLTVYNFAHIGNLRAYVFADTLKRMFLFNGYKVRHVMNITDVGHLTGDEDEGEDKMEAGARREGKTVWEIVDFYTKAFFKDLERLRIILPTVTCRATEHVQDMIDMIQKIEANGYTYIAGGNVYFDTSKVPDYGKLARLQLDEEKIRSRVENDPFKKNPFDFVLWFTRYKYENHAMQWDSPWGRGFPGWHIECSAMASKYLGERFDIHTGGIDHIPVHHTNEIAQSEAAFGHEWVNFWLHSEFLVIGEGEKMSKSLGNFITLQTLIDRGYEPADYRYYLLGAHYKKQLTFTMEALDGAKSAMKKLITRIEELKELNESETRPNDDLMNEFHEAINDDLNTPKALAVLWKVVDSEDLRPGEKLSLIDRFDEVLGLGLSEVESKTIPEEVIELANQRDAARKERNWEKADELRQLISEKGYEVLDERDGYKIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F768</accession>
    <name>I2F768_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731539.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2137"/>
    <dbReference type="EnsemblBacteria" id="AFK07771">
        <property type="protein sequence ID" value="AFK07771"/>
        <property type="gene ID" value="Theba_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2137"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="331" mass="37290" checksum="B0E72F9E1088FC52" modified="2012-07-11" version="1">MKASPMVEIRDLRKWFPVKSGFKVKSHLKAVDGVDLEIVKGETLGLVGESGCGKTTIGRTLIKIYQPTGGEFLYRGEGSPEGGIDIFSLSESKMRPFRREIQMVFQDPYASLNPRMTVFDIIAEGLRVHSVGRSKEERKAMIAEILEKVGLRPEYMFRYPHEFSGGQRQRIGIARSIILNPSLVICDEPVSALDVSVQAQVINLLEDLKHDFGLTYLFIAHDLAVVKHICDRISVMYLGKIVETAETDSLFNDPLHPYTRGLLSSIPIPNPHLRSARNREIVKGDIPSPVDPPETCRFVKRCPRAFDRCWKESPSLKEVSDGHFVSCFLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F769</accession>
    <name>I2F769_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3887 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731540.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2138"/>
    <dbReference type="ESTHER" id="9them-i2f769">
        <property type="family name" value="Bacterial_EstLip_FamX"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07772">
        <property type="protein sequence ID" value="AFK07772"/>
        <property type="gene ID" value="Theba_2138"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2138"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033707_0_0_0"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3887" evidence="1">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="426" mass="48288" checksum="988BD0B2AC685BF7" modified="2012-07-11" version="1" precursor="true">MKRIFSIGAFIFLIIATLFGSEVLADRYLQLLLRGNYHLAYEMQSVRARALYSVDNMVQEFQQLEEEYGSYLFIFSTETSVLRGYTVYIFHAQFERGFIDFNVVVDDQGKIDTFVVQPTSQPGAIAEYIDTSKFDEFEITIGEGRYRLPAVITVPKEIDRYPLVILIHDSGALDRDSTIGPNKPFRQIAWGLATQGVAVLRYDKRTFVFGERLSQTSPSIETEVIEDVIKAITAASRIPSVSSIFLAGHGLGGRVAPTIAMRDSRVDGIILMATPSRRELQVIIDKQKYISSLNKGEIGQQTQLLTDYLQIALEGKLPPGAPVLAATAGYYYELDKMSPIETIRELEIPVLIVQGDADFESTVQDYIMFMNALWTKINVYFQLLPGLDHYFMPVEGEISTPDNYYEFRHVDGRLIDTLFSWIYIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F775</accession>
    <name>I2F775_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heavy metal-translocating P-type ATPase, Cd/Co/Hg/Pb/Zn-transporting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AFK07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731546.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2144"/>
    <dbReference type="EnsemblBacteria" id="AFK07778">
        <property type="protein sequence ID" value="AFK07778"/>
        <property type="gene ID" value="Theba_2144"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2144"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_0"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="682" mass="73948" checksum="35BA33C6AB4E1890" modified="2012-07-11" version="1">MKKYRIEGLDCPKCAAKLEDQLKRSGVDARIDFSSSTLIIDGQTFKEVEEVIHKHSPEITLLESPDVEKDLPIKELVKLLFSGVLFFIALVFSPFIHGNNELLEYGLFVTAYLVAGGNTVLKAFRNLFKGDLFDESFLMTVATMGAFAIHELPEAVAVMIFYSLGELLEAIALRKSRRSVKELIDLRAEEVNQIIDGQLRTVPASQIQPGDRFVVKPGERIPIDGLVNSGSTWIDKSLLTGESSPVPVKEGDIVLAGTINKSGVIEVTASTNLQKSYTSRMLELVEEGTSRKSNRERFITRFSKLYTPTVVSIATAIAVFPPLLFGGGFSDWVHKALILLVISCPCALVISVPLSYFVGIGKASREGILFKGSNYLESLGKIDSIFIDKTGTLTKGKLEISQIETSGRYDKRELLEYAALMESYSTHPVASSFRSFIPEIPEDMKISHHSEIAGKGITAEINDKKMGIGNSSLLKDLGVDYKERGESGKIFLSIDGRVEGVFTLSDVLKVDSADAIIKLRELGIHEIVMLTGDSHDIAGSISSKLNLDGLISEAIPEDKMRAVEDAIKSGKRTAFVGDGINDAPVIARADVGIAMGFSGADAAIETADVVLSGESLSKVARAIEISRSTNRNAIQNITAALGVKMAFIALGAFGLMNMWGAVFADVGVTLLAVLNSLRMLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F784</accession>
    <name>I2F784_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07787.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_014731555.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07787">
        <property type="protein sequence ID" value="AFK07787"/>
        <property type="gene ID" value="Theba_2154"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2154"/>
    <dbReference type="eggNOG" id="ENOG5030M08">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287597_0_0_0"/>
    <dbReference type="OrthoDB" id="1824266at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="214" mass="24596" checksum="7A245647B3875299" modified="2012-07-11" version="1" precursor="true">MILNVVLIALVILLAAFILMSRRKTSFRTESIIHKVERISELSTARMTTLLIFEPERESLVPGTFQRFIFIVPFQVRGYVDLRKLKEDSIEIHEGEARRIKLILPSPRLEVTIPQSKIPDIRVINQSGVLTRIFGNKDMLKIFQSYSDKIEKQALQNASEMGVEETSRESARNFFHGLFLGMGFDEVVVLFEQDNSLETNVEIEKAGNQRKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A5</accession>
    <name>I2F7A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2175"/>
    <dbReference type="EnsemblBacteria" id="AFK07808">
        <property type="protein sequence ID" value="AFK07808"/>
        <property type="gene ID" value="Theba_2175"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2175"/>
    <dbReference type="HOGENOM" id="CLU_1473560_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="183" mass="20851" checksum="8B1EE9933A21C6C1" modified="2012-07-11" version="1">MKKVTVYYMASAGILFVLNFSKGAYFHPVFFFLPFLIIVDYLIVSGIPGRSYSIRISAFLRNIQSILTLRRTFDESTKGKIIDSENLRNLEKVVSSLEEKLKKPSELQRKLYIFSAYAAPLFPLAVMLSSVIVQRRVEIVAGLFSYVASLIIVLLSRKAFSNLEKTIEKLNEEIRKAVDDITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C1</accession>
    <name>I2F7C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487699.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07824">
        <property type="protein sequence ID" value="AFK07824"/>
        <property type="gene ID" value="Theba_2191"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2191"/>
    <dbReference type="HOGENOM" id="CLU_1946272_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658583" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="129" mass="13898" checksum="1D72067F4AC9F7CD" modified="2012-07-11" version="1" precursor="true">MRLTVVLLLLCLLSVSFANGLEQTKQTRVELPGCYIIRCYGSCFRGDQGYDCVLTGRAANFDGNGNPLAVTLHLYLDCYVVYFIVQSCSSSGEFSGIGEVEGSVGCFINTGPYEGSCFTYESSCACSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G2</accession>
    <name>I2F7G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731624.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2235"/>
    <dbReference type="EnsemblBacteria" id="AFK07865">
        <property type="protein sequence ID" value="AFK07865"/>
        <property type="gene ID" value="Theba_2235"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2235"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="303" mass="34520" checksum="C2AD92D678C27D17" modified="2012-07-11" version="1" precursor="true">MRQSHSKSPRSFRREVGSWLFLLPHLFFFILFVAVPLVFGLIISFFNWSLLKENVFIGFNNYVRTWNDSRFWPTVQHTVIFALISVPLVIIVAILFAHILKKKRFGQLWLLVAFVSPAFFGSVGILSSWKWIFASFPSGLANYYLDKVGLINKAVSWFGSTSVAWGVIILVTVWWIVGFSILLYLGALQRIPPEQYESAKLDGAGPWKRFIYITLPWIKSVLFFDVVRQAILAFGLFDQAYILSGGGPAGTTRTLVYYLYLVGFERQDFGRAAAISWYIFAIVLIFAVIQLVLVTKSIRSTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M7</accession>
    <name>I2F7M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR type III-B/RAMP module RAMP protein Cmr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731685.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2302"/>
    <dbReference type="EnsemblBacteria" id="AFK07930">
        <property type="protein sequence ID" value="AFK07930"/>
        <property type="gene ID" value="Theba_2302"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2302"/>
    <dbReference type="eggNOG" id="COG1367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058787_0_0_0"/>
    <dbReference type="OrthoDB" id="1506787at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007522">
        <property type="entry name" value="CRISPR-assoc_prot_TM1795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01894">
        <property type="entry name" value="cas_TM1795_cmr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="352" mass="40257" checksum="5D557D2E98238FEC" modified="2012-07-11" version="1">MESGPITFRVKTLTPLWTGGSDGKMDRVHETGIIGSIRWWYEVIARGLGYYVCDPTSDNRCKLSGKENDGEERISKLCPACYLFGTTGWKRMFSLSVTVDGKQPVRGNEPFSQATTNNINKNWLSKIFEKNLYDRDFFGSLELRVFPRCDRNQIEKQLKAVLSIMSNFGSLGAKPQFGYGLFELTDDAEETKESLRIINRFLKENCFVKKSGDEKGFSLKNYWKIETEVGKSLPPANLEYLGSEVKNSYIPMSFDVRYMLRKEYFGKCGSKKATAEIFGRTKGDKSASKVFVSSFYKEDQKNEKYKLRIWGFTARAVSEIIREAIERDYQTNSDGEIFSFGEMLSEVTEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R5</accession>
    <name>I2F7R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2343"/>
    <dbReference type="EnsemblBacteria" id="AFK07968">
        <property type="protein sequence ID" value="AFK07968"/>
        <property type="gene ID" value="Theba_2343"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2343"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094015_1_0_0"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="186" mass="21245" checksum="50EF5A0DF73046BA" modified="2012-07-11" version="1">MVLKALVSLLPEDLDRFVRGIWDELKTEFGFYSVFLTPFPHITFCIVEEEETGIDPLIEVIASSTPPLMARTEYLGVFSGEKPVIFIGLARNSRLASLHHALWTELRDSVNNRAIAYDEDHWIPHITVVFGDDLKRSNIGPVMERLAFRDFHHEFTIDNLTILEEVPDEGIVVRKKLKLAGQSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R6</accession>
    <name>I2F7R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731719.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2344"/>
    <dbReference type="EnsemblBacteria" id="AFK07969">
        <property type="protein sequence ID" value="AFK07969"/>
        <property type="gene ID" value="Theba_2344"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2344"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024249_0_0_0"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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            <end position="213"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="270"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <location>
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            <end position="667"/>
        </location>
    </feature>
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        <location>
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            <end position="692"/>
        </location>
    </feature>
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        <location>
            <begin position="191"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="706" mass="78049" checksum="C2CB2A1D5DBE7E58" modified="2012-07-11" version="1" precursor="true">MRRAISFIILAVVVVILLSGINGFSFDPSPAAFLSDDDSELEAFNKIAEVFGDTGSIVLILEASQTSLELLKSVTEKINSLDWVKSALSPTEAVKLGSFNLFTMSIPSGSYVYEDEGRLVLNEELLTDPVYSNLIVSSDGRYYAIMITIAEGNELKSDMMIPELRSVLDSSGVESYKLIGESVANFETFRSIFDLTFKYPPFILLAIMAVYMIKFRRISLSLLTLVPPLAAVMVIVGIMGLLKLSINSLTVMIPSFIIIIGSAYGMHFLSRFEENIHMKNAVRRTIHEERVPILFSALTTMAGFSSYILLDMKAFQEMGIFVCSGIFLSAIFTITVLPGLVTPKAGTKREVLPPRDVHPLVKRAVIWVVVATSIVSPLLIITIPMTIDQYNFFKEDSEIRESARTMKEAFGWLTNYTLMVEPAKGASISFTGDQVENLEAFEQELKGIEGVSKVLSLFDLSRETNVPLPLMIRVLNSTEAFGDSTSLLVSDNAIRFNIFSSQSDSLSAERLKAAVEKAIRKFPEMNKNFEFTLAGTTLIWESVNSSVVKNQIQSLIVSFGLIILLLFSIFRSLKSTIIATIPILLTALFNFVFMAVFRIPLSISTALISGMLMGLVIDYAIHFTIWFRRFGDSHKAYEQTARAILTNGISLVAGFSVLLLTPLLLYVDVAKLMVSGLAVGMVLTLILLPEIASRSERFLSRGKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T0</accession>
    <name>I2F7T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite ATP-independent periplasmic transporter solute receptor, DctP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731731.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2360"/>
    <dbReference type="EnsemblBacteria" id="AFK07983">
        <property type="protein sequence ID" value="AFK07983"/>
        <property type="gene ID" value="Theba_2360"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_036176_1_3_0"/>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DctP_fam"/>
    </dbReference>
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        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658599" evidence="2">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="333" mass="37751" checksum="9D294CF1206F8F03" modified="2012-07-11" version="1" precursor="true">MKKAFILVFLLLTVFVCFAVEETYTIRFNTVAAPTQPQVLAMNKFAEVVENLSGGKIVVKVFHSGQLGDQQTSLLAVMRGDLEMAGDGAPSWFADLGNMPKMGVLNAAYIFKSLDHMYSVMNSPMVKGWFDELASNTGMRVLDTWYLGMRQLNTTEKAGPVYKPEDLKGMKIRMPNNEAFMDMGRAIGSNPTPMGFGEVYLALKLGTIDGQDNPLPTDLSAMFVEVTKYIILTDHSIGMINPVINEKFWQSLPFEYKTYIIKALEVARYYMNYLVLEQESKLLKQFVDEYNMEIIVPDKEAFMNLARDFYSDEKFDKAWGEGMYETIQSYPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T6</accession>
    <name>I2F7T6_9BACT</name>
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        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2368"/>
    <dbReference type="EnsemblBacteria" id="AFK07989">
        <property type="protein sequence ID" value="AFK07989"/>
        <property type="gene ID" value="Theba_2368"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2368"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="30474" checksum="12183E2B31619D79" modified="2012-07-11" version="1" precursor="true">MSKKLFITLIIISIIFVIPIYWAAITSFKPSSEVLSYPPSLVPKQPTLAQFTKLFTAGDSIFTRYVLNTFILCGLSIGMVLILSIMGGYSLSKLAFKGSNIIFVIILSIMMVPYQSLLIPLYDLMNAMGLLDSLFGVSLIYTTYSMPFCIFMMKNYFSSLPNTLRESALIDGASEMRILFKVHLPLALPAIATVIVYVFLMTWNDFILALNFTSSNDVRNIQVGITLFATTRFTRDWGLINAGATFSIIPSILVFLLLQKYYVEGMTAGTNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W9</accession>
    <name>I2F7W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489940.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2405"/>
    <dbReference type="EnsemblBacteria" id="AFK08022">
        <property type="protein sequence ID" value="AFK08022"/>
        <property type="gene ID" value="Theba_2405"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2405"/>
    <dbReference type="eggNOG" id="ENOG502ZQ7X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2554311_0_0_0"/>
    <dbReference type="OrthoDB" id="2095061at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="82" mass="9045" checksum="61A0A4E778D88301" modified="2012-07-11" version="1" precursor="true">MTFYITMAATISSIVMLVWFAAGSNPWRLLVAYSAISTRLLIGIIFIEMVTSVDFVSSVALLFLILNTSGTIIAAYYMGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X9</accession>
    <name>I2F7X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731772.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2416"/>
    <dbReference type="EnsemblBacteria" id="AFK08032">
        <property type="protein sequence ID" value="AFK08032"/>
        <property type="gene ID" value="Theba_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2416"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="119"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="346" mass="39033" checksum="DE0B66A1316FA12C" modified="2012-07-11" version="1" precursor="true">MFWKYMLKRVFYGIFIYIILIFVFSALFNTVMEQTLRGQIDEEIRGELMALDNRSSQQIQDFIEMRRAEKYALYRLDKPIFERIVWRTWSTLTFNLGKSSSIRSAAGDRDVWSIVSEKIPRTLVLFSTAMLVDIFIGIWLGLKKAQKAGGLLDKSTSVGTMVVFGMPSWWLGMILIMFFAYTLKVFPSGGLHATPPPEGIAFFLDALYHLALPVMTLVVIGFWGRAFLTRNIVLGVLQDDYIMAARARGIPERKVLYGHTMRTSAPPIVTMSLLALLASVSGNIVFEGIFNWPGMGNLFWFALQQNDVPVLMGNLAITTGLYICGLVLLDLVYGLLDPRIKVGGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F876</accession>
    <name>I2F876_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489554.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08129">
        <property type="protein sequence ID" value="AFK08129"/>
        <property type="gene ID" value="Theba_2525"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2525"/>
    <dbReference type="HOGENOM" id="CLU_1775247_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="15343" checksum="0C4B0B2A1986A1C5" modified="2012-07-11" version="1" precursor="true">MKKGIFLAIVGAAMIIAGLFLPIVRFPGGGEATYFNGGDLYGALTMAIAIFAGIMGIVKMRSMVFLSGLASIGVVVARLITVIRDLPDENSLRTQFKALIQSNVPGSSGEEIANIIGGPQLHWLGWTILFAGGVVVLFAAFISSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D2</accession>
    <name>I2F8D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489440.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2585"/>
    <dbReference type="EnsemblBacteria" id="AFK08185">
        <property type="protein sequence ID" value="AFK08185"/>
        <property type="gene ID" value="Theba_2585"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2585"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="35034" checksum="74D24CF143561A3C" modified="2012-07-11" version="1" precursor="true">MAGRRERKTFTERNLLIILVVMWVFLAIATGGNFSSWANITNLIRQSSINGVVAIGMTLIIITGGIDLSVGSIVGLSGMVFAIFTSTRGEFQFPTIVGILLALGISALIGLVNAVAVHDGKVPAFIATLGMMTLVRGVVMYISSGRMVTAVPLEYRRFAVLEFLGIPALAWTWIILAGFMMLVLKYTKFGRNLYAIGSNEEAARLSGINIRLNMYSFYIVAALFSAIAGLMLGTRMAAGVPTGGDGYELDAIASVVIGGASLSGGVGTVLGTALGALIIQTIRNGGNLLGVDPFIMQIVIGAIIILAVFFDQFIKSRKKGEGLKKLFKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E0</accession>
    <name>I2F8E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731909.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2593"/>
    <dbReference type="EnsemblBacteria" id="AFK08193">
        <property type="protein sequence ID" value="AFK08193"/>
        <property type="gene ID" value="Theba_2593"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2593"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_0"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="37165" checksum="2227BAD697EB1F0F" modified="2012-07-11" version="1">MKYKKVEKIDEKLSALGYGCWGISGPSFWDGTTDEDSIKTIQRAIAGGINFFDVAPVYGLGHAEEVLGKAIKGLRDKIFIATKCGLLWDDQGRTRNCLKPESIRKEIEDSLRRLGTDHVDLYQLHWPDPEVEIEETMETMVELKKEGKIRYIGLSNFSIPEAKRAMKVGEVCSMQGLYNMLERNPKSYHNIPLDYRVEDEVLPFVLENGMAFLPYSPLFQGLLAGAISDKKKFSEHDVRAANPKLNSPEFKKYYEVVVKLNRLAHEIGKPLSHIAINWLIRNEAVTSVIAGAQKVEQIEQNLGAVEWDMDDGLYERIEEIVSSSNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F5</accession>
    <name>I2F8F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731918.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2608"/>
    <dbReference type="EnsemblBacteria" id="AFK08208">
        <property type="protein sequence ID" value="AFK08208"/>
        <property type="gene ID" value="Theba_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2608"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_1_1_0"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="288" mass="31735" checksum="F7206BE5A7FDCDC1" modified="2012-07-11" version="1">MTRKIIAMDGGGTNLRVTCISSEARFRKNYGTGVNITAVSSANLVSIFSLVRDDVGIPDYIVAAFSGAGDKTREEKLRQALHYVFGNIEIEVIMDIEGLYRAAVGEARGVVVVSGTGSTVYGHDREGKAVKSGGWGHIFDDEGSAYWISKELITASLKYRDGLIPHDPIFDKLVEFFEMSTIEELVNLTLMPDMKTEIASFSRVALENPTGLARRIADEGIEILAKRTLNVLEKTGEVETIHTFGGSFASAYYNNKYSEMINNHRTTLFTGNVDEILAEQAFEKLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F7</accession>
    <name>I2F8F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489409.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2610"/>
    <dbReference type="EnsemblBacteria" id="AFK08210">
        <property type="protein sequence ID" value="AFK08210"/>
        <property type="gene ID" value="Theba_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2610"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="31077" checksum="F24D9F128BC24A98" modified="2012-07-11" version="1">MLKLSLFGKIVVYFLLVVYCLIILVPFFIMIMNSLKSMREIYLQPFSFPSKVLFENYSKAWQQAGIGTGYKNSLIVAGVSVIGIVIVSSMFAYAISKYTFKGRRFLFIYSMLGLAFPARLAIIPIFILMRNFDLTNSLLGLIIIYTSINIPFSVFLLKNFIDGVPNELSEAARIDGASPMQIYWRIILPLVKPALSIVSIVSFVNVWNDFFFPLIFITDRSKATITLAVSIFFGEYVNQWHLLFSGLTLAVAPTIILFLLFSRQFITGMTQGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G4</accession>
    <name>I2F8G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731925.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2617"/>
    <dbReference type="EnsemblBacteria" id="AFK08217">
        <property type="protein sequence ID" value="AFK08217"/>
        <property type="gene ID" value="Theba_2617"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2617"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658448" evidence="1">
        <location>
            <begin position="20"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="415" mass="46375" checksum="0BA2D08CF7561E41" modified="2012-07-11" version="1" precursor="true">MKKLLVFSLSALLFFSVSAFGLVTLEYWTGFTGPDGSFMQELVDKFNEEHKDEIQVNMSTMLWADYNTKVPIALASGKGPDVGIAHVDNIRSFVSQGMLLPLDEYLEIMNMKEGDIVSSVWDAVHVDSSVYGIPLDVHPLVFYWNKDLFEEAGLDPENPPTTRDEFVEAAKLLTKDTNGDRTIDQWGTMIPVGWPNYFIWFSTFFSNGGVLFNEDLTKAAFNSPAGIDAMQFLVDLVFKHKVSPEKVQVDADIDAFKRGTCAMEFNGIWMLTDYMKVEGLNFGAGPVPQLGSEKPANWAGSHTMVIYKQRKQDKERTEAAAKFISWISNHSYEWALAGQIPANISVQNSPEFLSLPYHSTIAKGAEYVVFPPFFPKYGDATGPIWEALNLAILGQKTVEQALSDAERISNEILQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H9</accession>
    <name>I2F8H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731939.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2632"/>
    <dbReference type="EnsemblBacteria" id="AFK08232">
        <property type="protein sequence ID" value="AFK08232"/>
        <property type="gene ID" value="Theba_2632"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2632"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_1_0_0"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="255" mass="28595" checksum="D49626C01E3A5E7D" modified="2012-07-11" version="1">MEKRLPILEHNNERPAVIEPAKVISSIPEMPERAVILFYQDVIETLLNKGLLKKIVDRRSEVGLYPVYEIEYRGVKVAILNPGLGAPSAAGFYEELIALGVRKTIAGGSCGVLKREIPRGKIIVVESAIRDEGTSYHYLEPSREIAVDTEVLEKVEVSLEALSIPHIKGKTWTTDAFYRETKKIVKERIDEGCIAVEMEASALMAVSKFRNVLFGQLLSSGDDVSGEEWDRRFHPEADSHKERVFWAAIECCLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K9</accession>
    <name>I2F8K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type metal ion transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731960.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2663"/>
    <dbReference type="EnsemblBacteria" id="AFK08262">
        <property type="protein sequence ID" value="AFK08262"/>
        <property type="gene ID" value="Theba_2663"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2663"/>
    <dbReference type="eggNOG" id="COG1135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_3_0"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="37300" checksum="F9C31F3A6AC25433" modified="2012-07-11" version="1">MILRVEKLNLSFEDKSGKRKILDDVSLSVEEEEIVGIVGLSGAGKTSLLRTLNLLQPVDSGSIFFDGLDIVGLKESEVRNVRKKIGVVFQSFNLYRYRTLYQNIAFPLKIQGVSKKEIEERVMNIATELGLEHRLRAYPSQLSGGEQQRAAIARALVMDPKMILLDEPTSALDPKTTGRLLDLVVSLNEKHGITFIVVTHDMDVIKRTCDRVAYLQNGKLDFFGPTHEFFVKIENNEVSDFGKPLELEKTLLSANKKILRVLFWGTRTHEPVLWKIAKENDVMINILYGKIEEFKNGPFGTLIIGVEGEKQDLFVEKLRESVFFLEEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L9</accession>
    <name>I2F8L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731968.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2673"/>
    <dbReference type="EnsemblBacteria" id="AFK08272">
        <property type="protein sequence ID" value="AFK08272"/>
        <property type="gene ID" value="Theba_2673"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2673"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053687_0_0_0"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="370" mass="42311" checksum="5ACD32A615DBFD19" modified="2012-07-11" version="1">MLIEEFRRRIDGLREEISSRGAGAFLISKCCNFSWVTFGARSHITLNSTEGEASVLVTLDRVYIITNNIEKQRIQEVEFHEELLGEFGFLEYNWFETYGEKRLIDNLLKGKLLSDTGRYDSEYVDLTEMRTVLSVYEIETYRALGRDCDDIFSSIIPGLKRNMTELEVQGLFYEAMSKRDIEPILTLVFSEDSSLSYRHNLSRNVKLDRRGFVSICARRRGLIVSSSRSFMFEPVEEISLQHERNCFVDAVAIDSSKPGERLSNVFEKLVEAYEHVGRGGEWKLHHQGGVAGYLPREVHGNLKSDFILKRGNAVAWNPTIRGTKSEDTVLIGDFGDSNISFPQTSSWPELKYEFDGSTVRRPAILLVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S3</accession>
    <name>I2F8S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732019.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2732"/>
    <dbReference type="EnsemblBacteria" id="AFK08326">
        <property type="protein sequence ID" value="AFK08326"/>
        <property type="gene ID" value="Theba_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2732"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008645_2_1_0"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657703" evidence="3">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="307" mass="33852" checksum="3C0BD8218C489C14" modified="2012-07-11" version="1" precursor="true">MKHFVLLLLILLVSVPSFGSSAIFQKSWGVQGTKNGQFSDPQGIFVDGKDLVYVADTLNHRIQVFDKNGKYKTSFGNYGSENGEFLFPHDIVVDSKGFIYVADSQNGRVQKFSSKNKFVKSWGGKGPEPGQFDGPMYLAIDRSDRLYVGDAFNQRVQVFDNEGTLILTVGAKVGMFDAMNPGNLATVSGLNVDNNGYIYISDDIVRRIQKYDPEGNFVAEWGSGYSGKWGQPGGSTIDSSGNLHYINKMNNMVVVLDPKGSFLFEWGGSGTAHGLFTRPIDLYFSDDGSVFVLEQSGNRIQRFGISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S7</accession>
    <name>I2F8S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="1 2">
        <name>pTHEBA.01</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
            <plasmid evidence="1 2">pTHEBA.01</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003533">
        <property type="protein sequence ID" value="AFK08330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732022.1">
        <property type="nucleotide sequence ID" value="NC_017935.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08330">
        <property type="protein sequence ID" value="AFK08330"/>
        <property type="gene ID" value="Theba_2737"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2737"/>
    <dbReference type="HOGENOM" id="CLU_2700482_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Plasmid pTHEBA.01"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="73" mass="8628" checksum="52E997CCE7E9C7A6" modified="2012-07-11" version="1">MSMYKKIKRVISFSPKTWGRLDGLSNRMDTPISTLVNMGIAWWMDYNELFKRSPEVIAKLMKMKEEINGEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1F7</accession>
    <name>I2F1F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729943.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0003"/>
    <dbReference type="EnsemblBacteria" id="AFK05760">
        <property type="protein sequence ID" value="AFK05760"/>
        <property type="gene ID" value="Theba_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0003"/>
    <dbReference type="HOGENOM" id="CLU_2936260_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="65" mass="6947" checksum="8AA824331BBBC0D8" modified="2012-07-11" version="1" precursor="true">MKYAVSFLLFLVSAAAIIGTISDSQASRLRESMNEKSGAFPNMVDGVFAVSEGCISLEVIDSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K3</accession>
    <name>I2F1K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729980.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05806">
        <property type="protein sequence ID" value="AFK05806"/>
        <property type="gene ID" value="Theba_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0055"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_8_1_0"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="166"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="313" mass="34470" checksum="6AD5559A56FC6B4C" modified="2012-07-11" version="1" precursor="true">MDILKKKWMAALTAVFCSVLWGSAFPVLKLSYEEMSIAPDDVSAKLVFAGIRFLGAGIIVLMLSIPLGRKGRTRFAKKDYLHLLALGILQTFLLYFFFYNGLSYTTGMKSSIIMAGENFLVILLAHYIYKNDRLSWKKTIGMILGFAGVFLANFEVGFTLSFVFLGDGFMLIAATIGAFGTMYAKWMSSRRSPFLVSGWQLSIGGFLLLIAGFPGLKGDSLVFTLKGDLLLVYSMLLSAIAFSLWYAILSFHKAGEITMFRFVIPVAGVFLSAAFIPGEALNSYMAFALVLVSAGIVVVNWKKRVVSEDNSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M6</accession>
    <name>I2F1M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730002.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0078"/>
    <dbReference type="EnsemblBacteria" id="AFK05829">
        <property type="protein sequence ID" value="AFK05829"/>
        <property type="gene ID" value="Theba_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0078"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="374" mass="40877" checksum="7F83E42D9D1112C9" modified="2012-07-11" version="1">MSFTERRSAGVPSELRERNLKTIIDVVFRYQPVSRTNIAKLTGISKPTVSKLVGLLMSENYIVKTGKTSSGLGKRQELLSFNPEKAFVISVDVGLATTIVAKVDLSMKMTNKCEIKTSESPERFASELVDCLSDFCGAGKESPASVVISVPGLVRSDLRTAINVPLLHWTDLPLAELVEERLRLNGIVCGVSINNDSKLGVLAEVALNKDIPDSFSNIVYVLVKEGVGVGLYINGSLYVGSNHIAGEFGHMSIDPKGPECSCGRRGCWLTMVGSRELDGFIRENRLEDYIELFSVGLMNIVNGLDPNLVVISGALEQYWERVLPSLRAKLKSIALFDQSSMEIMKSALDDREGPIFGGALMVLRKYLDIETGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N6</accession>
    <name>I2F1N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05839">
        <property type="protein sequence ID" value="AFK05839"/>
        <property type="gene ID" value="Theba_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0089"/>
    <dbReference type="HOGENOM" id="CLU_2302543_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="100" mass="10637" checksum="238986F4FAD9D78B" modified="2012-07-11" version="1">MTRSAGYRLQGLGSREENWQSIQGFNATEEVVQAAVSGSPSLCHPGLDPGSALLKTVAGGSALVVGKSRRTRCPLNSSPFSEKNGCKFQVASCEKKKTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P0</accession>
    <name>I2F1P0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730013.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0094"/>
    <dbReference type="EnsemblBacteria" id="AFK05843">
        <property type="protein sequence ID" value="AFK05843"/>
        <property type="gene ID" value="Theba_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0094"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813253_0_0_0"/>
    <dbReference type="OrthoDB" id="1454254at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="343" mass="39343" checksum="A18E8B205FE6CF78" modified="2012-07-11" version="1">MENKKAGNIHVRFASIDDNEKLLKIERESAQEGSIWLVAFREDFFGRLKYFEEGFIMIAEDAYDIIGCIGVGIDNLIVNGEIKKAIYLFGLRTNPKYRLKVARWLKSIIQELQNLLGPTDFDFGYASVKADNIASKKILKHMGFSTTAILDFYACPVRKTSQEKSVFVEREVDLETILDLYKPLEKDHDLLLQGTKAFEVMITERRLWLFKTEGAYALVLDTSGEQDFGITRLSKGLRAFQLLAQGTLSPLVRIPKMNERLRSWDVLLFGWDDIRSARKIVRKIHRCAWEEGITLINFSRDRSLGSMKGAVGSLSFRIPFEIMIYEKNSINRGSRPIIRTPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R2</accession>
    <name>I2F1R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730031.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05865">
        <property type="protein sequence ID" value="AFK05865"/>
        <property type="gene ID" value="Theba_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0116"/>
    <dbReference type="HOGENOM" id="CLU_2753183_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="70" mass="7094" checksum="7936E89140D00E46" modified="2012-07-11" version="1" precursor="true">MKRITAIVLFMLFVFGIALSINGSGPGDGVPDGPDDDAGYGAPDDSCEGNGPGQGKPALDEDEIVIAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1R6</accession>
    <name>I2F1R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05869">
        <property type="protein sequence ID" value="AFK05869"/>
        <property type="gene ID" value="Theba_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0121"/>
    <dbReference type="HOGENOM" id="CLU_2538643_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="83" mass="9516" checksum="C754F2C78EE200F2" modified="2012-07-11" version="1">MALYQLQGFDSKRSRRGVLLKEFDLTLEVQRSLIRMYVVVLAKEENKNGALCLLRPRGHPMQKYYDTMVYLSSVLSLSSEAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S4</accession>
    <name>I2F1S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730042.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0131"/>
    <dbReference type="EnsemblBacteria" id="AFK05877">
        <property type="protein sequence ID" value="AFK05877"/>
        <property type="gene ID" value="Theba_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0131"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157172_0_0_0"/>
    <dbReference type="OrthoDB" id="1841820at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="95" mass="10865" checksum="7B491B094ADE58C1" modified="2012-07-11" version="1">MNPRVYEFDAVIRKVPDIDGAYIEFPYDIREEFGRGRVKVHVTFDGEPYDGSVVNMGMKNPDGTICYVIGIRKDIRSRIGKKPGDSVKVTVRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S9</accession>
    <name>I2F1S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05882">
        <property type="protein sequence ID" value="AFK05882"/>
        <property type="gene ID" value="Theba_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0136"/>
    <dbReference type="HOGENOM" id="CLU_3409652_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="29" mass="3181" checksum="BBBDC7F7869479FF" modified="2012-07-11" version="1">MIRIADLLLRTVDLINGIAMNLAETLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U3</accession>
    <name>I2F1U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730061.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0154"/>
    <dbReference type="EnsemblBacteria" id="AFK05896">
        <property type="protein sequence ID" value="AFK05896"/>
        <property type="gene ID" value="Theba_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0154"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_0"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="281" mass="30175" checksum="0DE0F6F815E83BBE" modified="2012-07-11" version="1">MPLVPLTEVLKDAQAKKYAVPGFNFHLYEDLVAIVEAAQEARSPVILMAAGTCMKHWGPTLAAALIKEVADSVDIPVVAHLDHASSLELIFKSIHAGFTSVMYDGSMLPVEENIANSKIVVKVARAFDVSVEAELGRVAKGEEGESAVEILTDPSDVVMFCEATDVDALAVAVGTVHGMQKQEAKIHLDLVDAISEVSPVPLVLHGSSGVSDNDLRYIATTGFSKINIGTRLKTVFTEGIREVLQNDPDLNDQLKLLKLAVPRVKDTVKEKIELLGSGNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V5</accession>
    <name>I2F1V5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Homoserine kinase</fullName>
            <shortName evidence="10">HK</shortName>
            <shortName evidence="10">HSK</shortName>
            <ecNumber evidence="4 10">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrB</name>
        <name evidence="12" type="ORF">Theba_0168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730072.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0168"/>
    <dbReference type="EnsemblBacteria" id="AFK05908">
        <property type="protein sequence ID" value="AFK05908"/>
        <property type="gene ID" value="Theba_0168"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0168"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_2_0"/>
    <dbReference type="OrthoDB" id="610857at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="79"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK05908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="282" mass="30941" checksum="CECB6E421A72E3C0" modified="2012-07-11" version="1">MRLRAPATTANMGSGFDVVGMALKLHNVVQFEKADRLKVLCIGRYGQEIENSEGLFEKAIKGFEKVTGKAVPGVQIIQECNIPPARGLGSSAAAIASALFIANIVTGGSIPMKTLLQIGTEIEGHPDNIVPCMLGGLVVSYYDGEKLDYEKFEMTDQRLTFLVPEFKLSTGEMRKALPESVPFRDAISNLKNVSQFISKIAKGNLIEAFRYTHDSIHQIYRINSDPRMKELISCIEGRNTNYWFVSGSGSSVCCDLEDVAGLPYLEAVIRTSPANEPFIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z4</accession>
    <name>I2F1Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491453.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0213"/>
    <dbReference type="EnsemblBacteria" id="AFK05947">
        <property type="protein sequence ID" value="AFK05947"/>
        <property type="gene ID" value="Theba_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0213"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="344" mass="38749" checksum="062404D4634A0A35" modified="2012-07-11" version="1" precursor="true">MTAYIIRRLLLLPLIMIGVTLIIFSMIWALGPDRLLASYVKSPEALKTPDAAERLIKKYGLDEPMPVQYLKWLGNILQGDFGYSMVGKKGVLPSMLERFPYTLELTIYAIVPVILVAIWLGVISAVNQNKFTDQFIRVFALVGWSLPDFVFGLLLLLVFYSILGWFPPGMVSTEFDLVMRSDEWRTITSMPTFDALLNGRLDIFIDALRHIILPVLTLAYLWWAYLLRITRSSMLEVLRKDYIRTARAKGVPERTVIKKHAKRNAMIPVITVAGGSVMGLLGGTVFVETIFSRVGMGRFLADAASLLDYWSIIGGALFFSFIMVVGNLIVDVSYALVDPRIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F260</accession>
    <name>I2F260_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0281"/>
    <dbReference type="EnsemblBacteria" id="AFK06013">
        <property type="protein sequence ID" value="AFK06013"/>
        <property type="gene ID" value="Theba_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0281"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060930_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="28504" checksum="D5792C3969FED873" modified="2012-07-11" version="1">MTDFTERSKFRALVLGGYLEDVEVSGSGHKASIVKTDGGSAFNVATCLSLLGAEVLFLSCFGVCDSDRWSFRSIPVMPDCAHGIFLFSGSDVIAVQKPQPVDVNQELVGILIDEEYDLLYSTLEIGQQAASVISSVKSRIKVVDPSPFHEFKGLDGLGKYDFILANEYMSFEKSDRRLIIKASEKGVYFAGKDFLPPVVGKNRFGSGDIFGSVFSLLLMNGASPEEAIGEAVKVSGEFCSQTRSVEQFMLGIRSSLNYVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F266</accession>
    <name>I2F266_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ORF">Theba_0287</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730172.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0287"/>
    <dbReference type="EnsemblBacteria" id="AFK06019">
        <property type="protein sequence ID" value="AFK06019"/>
        <property type="gene ID" value="Theba_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0287"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_0"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFK06019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="247" mass="28024" checksum="E2691CA444C086E7" modified="2012-07-11" version="1">MKIEVLTIFPQLFETVFNWGVISRAIKNGIIAFESVDIRDFTDDRHRTTDDYPFGGGSGLVMKAEPIIKAVASRFSDDSKPHVVYPSPQGKLFDNKKALELSKLSHIVFVCGRYEGIDERAMSSIDEEISIGDFVLSGGEIPALLMIEVISRFVPGVVGDMESVINDSFFSDLLDYAHYTRPREVNGMEVPEVLLSGNHEMIEIHRRMESLLRTIERRPDIFLKHDFDLTDKKALLLLFKELKKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F267</accession>
    <name>I2F267_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltrn_RNA_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730173.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0288"/>
    <dbReference type="EnsemblBacteria" id="AFK06020">
        <property type="protein sequence ID" value="AFK06020"/>
        <property type="gene ID" value="Theba_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0288"/>
    <dbReference type="eggNOG" id="COG4752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1414575_0_0_0"/>
    <dbReference type="OrthoDB" id="1276858at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd18085">
        <property type="entry name" value="TM1570-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019230">
        <property type="entry name" value="RNA_MeTrfase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09936">
        <property type="entry name" value="Methyltrn_RNA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltrn_RNA_4" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="205" mass="23437" checksum="C2CF962CD2645951" modified="2012-07-11" version="1">MLNNIYLALIHYPVLGRHGNIVSSAVTNLDVHDISRTCRTYNVKGYFVVSNLPAQREIVDNVLNYWLEEFGREYNPSRSEALKVVERASYMEDVLEQIEEIEGQRPDLVFTSAKRGKDRITFDAMRRIIVKSEKPHLLLFGTSWGLPGEIEKICDYALEPLRANSDFNHLSVRAAVAIVLDRLIHEDTVEVRRDKDGSVHKISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F276</accession>
    <name>I2F276_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acpP</name>
        <name evidence="11" type="ORF">Theba_0298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491769.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0298"/>
    <dbReference type="EnsemblBacteria" id="AFK06029">
        <property type="protein sequence ID" value="AFK06029"/>
        <property type="gene ID" value="Theba_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0298"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_4_0"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="83" mass="9138" checksum="3013563D926FCD5A" modified="2012-07-11" version="1">MTVDEVFDRVKTIISEKLGVEEDEIAMDSDLTEDLGADSLDLVDLVMALEDEFDFKVEDEQIENISTVGDIVESIGKGLGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F282</accession>
    <name>I2F282_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730178.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0304"/>
    <dbReference type="EnsemblBacteria" id="AFK06035">
        <property type="protein sequence ID" value="AFK06035"/>
        <property type="gene ID" value="Theba_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0304"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_3_0_0"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="80"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="318"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="455"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117229" checksum="F32217A436BCAE18" modified="2012-07-11" version="1">MRKEWLLLKPDDEAVNRLVEFMGIDAFLARLLVTRGIDNEVEAMKFLNPDKTILHDPFLLEDMPLAVRTIIETRDRNESIVVFGDYDVDGVTSTALLYLAMKRMGFNVSYYIPLRLEEGYGLSKDAIKDLRDQGHSLLITVDCGVTSFDEIKFAKEIGFNVVVTDHHEVKDLLPPADAVVNPKRPDDDYPFKGLAGVGVAFKLLVALNETLHCPIDPEEYLDIVALGTIADIVPLRDENRYIVKEGTAKIQSSPLLGLKALLSYLRIPSENLTAQDIAFKIAPKLNAAGRMDSAIVALELLISEDMDSAMNTASRLLKHNQNRQTIEAKIFEQTERDLENTASFKDDFALVIDGDNWHLGVLGIVASRLVSIHNKPVFLIATNGSDGKGSARSPAGVSIISLLNEVSGLLREFGGHEMAAGFSIDKEKISEFRSAINDAYIKLYGLKQPVFKIDVDDVLTLDSITPSILDKLELLRPFGHSNPEPKFLIKGLNIEKAKMFGSGSDHVKLILRSGDRKTLAIGYNMGTMFDDFKYVKPNLLKVDAIASIKNDNLYGLQSVKLSLSDARLYIDPVFEEEVRDKNFVFEFIRDWKNQQPGLQIKSDVSALIAELEKKVSHKCPEFMDVSAKNPWGIFGNIRLKNPFLALKILKNYQKGKRTFIVSAINGTLAHTYYSLQHYLDSIKPIFANSLYRGKLDEPVVFVTLPFFVERFNEISDSAGEIIFDEPSYILSGIFKDHPDLEGFFNNIDKVLGISGFSGSIFCDDLKEFFLDKRISHVYKPSPIKRVGIIDNRGSRKKVEQVMSIVGHGENVAVIVDSPHKTVSLAKSMGSRLSHALQNGELIFYNYLLKDFQRSVIYSLVERQKIRVLITTPSSDGLGVTLGNSNIVFYSAPRNFLEVIDAVATRPGEDSELFLNLSFNKADLVSNTSEMDRLFPTVEELEAVYQDLKEVLPASERDIKKALSFEDGISKVFLSMLEEMELLSADNGVWYSNSEAALDTTQVKKTLRYREGVAEKRMTRWFATKLSTMTTRGLLRSLTNAEEVLKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M5</accession>
    <name>I2F2M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730292.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0451"/>
    <dbReference type="EnsemblBacteria" id="AFK06178">
        <property type="protein sequence ID" value="AFK06178"/>
        <property type="gene ID" value="Theba_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0451"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_0"/>
    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="403"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="480" mass="52114" checksum="F77E65D74F9750B6" modified="2012-07-11" version="1" precursor="true">MQAVVIGGGVVGCLIARELSRFRIKVVLVEKLEDIGQGVTKANSAILHGGYDDPPGTLRARFCAPGNLMFDKLAEELKFPVKRTGSIVVAKDRNELPKLEELLQNGINNGVKDLRIVGKNELRELEPHISDEFNYALFCGTAGITEPWMVAIASAMNVAANGGEVVTGEEVIGGKINEGRVTEVFLSSGRKIEADLVINAAGLFYEKVASAFNVNVPPVHLRKGEYILLDKKASELVNMIIFPLPTAAGKGKLVVPTVDGGVLLGPTSVELPEFSPEDVSTTDSGLTSVRESGEYLIPGIDNAKWFIKSFAGLRPETVQKDFYIKRAEELANFITVGAMRSPGLTAAPAIAEFVVSMIVPETGIDLVRRDDFVPCLEERVKIKELPAGKVSEMIDENPAYGRIVCQCNEVSEAEIVQAIRDGARTIDGIKFRTRAGFGRCQGGFCSWNIAKILARELKKDLSEVRQNSEGSWIVDGKVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2R0</accession>
    <name>I2F2R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0487"/>
    <dbReference type="EnsemblBacteria" id="AFK06213">
        <property type="protein sequence ID" value="AFK06213"/>
        <property type="gene ID" value="Theba_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0487"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="216" mass="23116" checksum="6BDF1792B7A674FC" modified="2012-07-11" version="1">MMDPKERIARRIGRELGDGDLVNLGIGIPTLVSNYIPAGIRVFFQSENGIIGMGPLPEEGMENRDLTNAGGQYVTALPGSAVFDSAMSFSIIRGGHLDVTVLGGLQVDERGILANWMVPGKMVPGMGGAMDLVTGAKRVIVAMTHTSRGNPKIVKQCTLPITSNRRVDLIVTELAVIEPFAGGLLLKEKASEVTVDEVQSLTEARLFVAEDLKDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V5</accession>
    <name>I2F2V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492162.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0535"/>
    <dbReference type="EnsemblBacteria" id="AFK06258">
        <property type="protein sequence ID" value="AFK06258"/>
        <property type="gene ID" value="Theba_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0535"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_0"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="16585" checksum="EAADFFBA6556F551" modified="2012-07-11" version="1">MKIAIGSDHAAYELKSFLVQYVESKGHSVIDHGPESGSLSVDYPDFADKVCKSVTDNDADYGILLCGTGIGMSIAANKHRGIRAALCLFPEMAALSRRHNHANVLVLGGRLIGSELAGWIVDAFLNSSEEGGRHQTRVDKLETDTFENRVNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F355</accession>
    <name>I2F355_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthosine triphosphate pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730435.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0640"/>
    <dbReference type="EnsemblBacteria" id="AFK06358">
        <property type="protein sequence ID" value="AFK06358"/>
        <property type="gene ID" value="Theba_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0640"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_0"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="195" mass="21660" checksum="8B6892053FAD9F57" modified="2012-07-11" version="1">MKLYLVTSNENKLKEVRLILPEGFDVESIEAIAPMKDIVEDAGTFFGNSLKKIEAYRDVGVPLLADDSGLVIESLGGFPGVNSARFMQNSHYSEKMQIILDRMVNEENRAARFVCAALFYDPSNSVLVGVEEQVEGIIARKQTGENGFGYDPIFVPQGYSQTFGVLGDSVKKELSHRGKAFRKLFSLVHLYTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F356</accession>
    <name>I2F356_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">Theba_0641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730436.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0641"/>
    <dbReference type="EnsemblBacteria" id="AFK06359">
        <property type="protein sequence ID" value="AFK06359"/>
        <property type="gene ID" value="Theba_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0641"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_0"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="295" mass="33643" checksum="4E7069879A5C0CE0" modified="2012-07-11" version="1" precursor="true">MKRIVISIVIASASAVALFFFLRAVFSGELILNPVIVENLGPFSVRWYGVMIATGIIAAYLLGRRQGLKEGIKEDYLIEGVFIGIVFGVLGARIYYVAFNYEIYRGDFWSIFRTWDGGLAIHGAFFAALLVTFLYVTFRKKADLKFLQVTDIFTAVLPLAQAIGRWGNFTNYEAYGSPTDLPWKMFVPLRYRMPGYSEFEYFHPTFLYESLANVVIFAVLYWYLGKRKNYGEVTALYMVLYSIVRFFVEGLRLDSLYIGQSEVRTAQAVSVILLVVGIALFIFSRYKGEQVKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F357</accession>
    <name>I2F357_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tig</name>
        <name evidence="13" type="ORF">Theba_0642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730437.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0642"/>
    <dbReference type="EnsemblBacteria" id="AFK06360">
        <property type="protein sequence ID" value="AFK06360"/>
        <property type="gene ID" value="Theba_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0642"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_1_0"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="12">
        <location>
            <begin position="249"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="434" mass="50078" checksum="B9298E47BDB242E8" modified="2012-07-11" version="1">MEKSFVKKEENVETFLFAFDSEEIRKAENDVARYVNQQYTIPGFRKGKVPLSIVRNFLAESFEEMVLEVLSDKIEEELKDEKILVPAVISEQKMEGEGAVIEVKLHRDPEVKIRDYENLDLKVPKQDEVVLNYVNNRLEELRNEHAIVEPKDGPVENGDLVKIEYTIIKDGKKIAENKVQELSVVPEDDRPIVKNIIGKTKDDVVEFTRTFEDSDNEYFYSVKVLDVLRKSPLDLDDEFAKTVNAEANTLEELKEIVRREGMESFLNWKKDFLRQQAMDKINDLVEIGISDATLDYLVQRTIENSKKEKSYEKYLKQAGSEEKLIEDLRSGVFDEIKKARFIDEIASREGFRAEEEEIQAYAEEMAPYWGISAERAKEMVNTRQDVKEDIVSTIIRNKVLDNVIEKASISDMEPSSDEQLEISESGGEEAPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F390</accession>
    <name>I2F390_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">Theba_0676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492343.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0676"/>
    <dbReference type="EnsemblBacteria" id="AFK06393">
        <property type="protein sequence ID" value="AFK06393"/>
        <property type="gene ID" value="Theba_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0676"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_0"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="102" mass="11583" checksum="CDFF9B0B9374536C" modified="2012-07-11" version="1">MAKQKIRIRLKAYDHKLLDLSAKKIVEAVKLTNAKVSGPVPLPTERTLYTVLTSPHKFKDAREQFEKLVHKRLIEILDPTPKTIDSLMKVDLPAGVDVEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F393</accession>
    <name>I2F393_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplW</name>
        <name evidence="6" type="ORF">Theba_0679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492347.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0679"/>
    <dbReference type="EnsemblBacteria" id="AFK06396">
        <property type="protein sequence ID" value="AFK06396"/>
        <property type="gene ID" value="Theba_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0679"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_0"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="99" mass="11436" checksum="D089BFEDBC9F2ED3" modified="2012-07-11" version="1">MIEKKYYGDVLLRPLITEKTVASGELNKYIFEVHRDANKQTVKDAVEKLFNVKVEQVNIMNMKGKPKKRGVFVGKSRSWKKAIVTLVTGYRIKELEGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B9</accession>
    <name>I2F3B9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">Theba_0705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0705"/>
    <dbReference type="EnsemblBacteria" id="AFK06422">
        <property type="protein sequence ID" value="AFK06422"/>
        <property type="gene ID" value="Theba_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0705"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="32"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="279"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="39172" checksum="F787EA46FD175E59" modified="2012-07-11" version="1">MCARILGETMLTSIMPKNLRIEEEREDDNSYFTRFILSPMERGYATTIGNSLRRVLLSSIPSMAITRLKIPGKYHEYDVIDGVKEDILEIILNFKKVQLKPALEFSDAVKLTLETAGPGVITAGDIKTPTGVEVVNPSQYIATLNTDSVIYIELFAEIGRGFVPVSEMEIEHDVEMIYIDGIFSPVLKVNFQTENVRVGKRTDYDKLILDVWTKKSITPSDALLRATDILIRHFEVFSNGLGKPGQGLTSSALKQEEEEIISEEAEVTVETPQVEEQDSNSLGAKKVEELDLSVRSLNCLKRDKINTIGDLLDKSEADLLRIRNFGEKSMLEVVKKLREKFNIVLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C9</accession>
    <name>I2F3C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730490.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0715"/>
    <dbReference type="EnsemblBacteria" id="AFK06432">
        <property type="protein sequence ID" value="AFK06432"/>
        <property type="gene ID" value="Theba_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0715"/>
    <dbReference type="eggNOG" id="ENOG5033RJQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803657_0_0_0"/>
    <dbReference type="OrthoDB" id="1480678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="345" mass="38291" checksum="193BA4B65533AF7A" modified="2012-07-11" version="1" precursor="true">MFQSMITAVNSDEGYTEIVRAVVEGRYLKPVFSVLKLGSDSLEEASRVFEENNSLPADEIFVTAFHPKDVVFQHLEVPRVKSVKNLVSVASFKAASQFSLPPDEVNVACLNSLSSLRTGLVPAFIITKKRALYEFIGELTGKNFPEPNIVDVKPFSIFKIAQTSVFEGNNIVFIVDKSYSLLLTLRGEEIVGLNYINDGFDEVASDFKEDNSLSPNTNMQREFLIGSKAYYDSLIEEASERLESMISYQLRMYLTNTLSNSPNTSAADESLFNRFFVAGQSSLSTAVYSRAFQQILGTETEVASMPLKMKETSGITYTSAGLLMRGGELLGRRKLVFKEEAGLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3E5</accession>
    <name>I2F3E5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">Theba_0733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0733"/>
    <dbReference type="EnsemblBacteria" id="AFK06448">
        <property type="protein sequence ID" value="AFK06448"/>
        <property type="gene ID" value="Theba_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0733"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="55" mass="6601" checksum="279DCD65C1EA39F0" modified="2012-07-11" version="1">MAKKTKGNKVLVTLKCSECGTRNYYRFKNRQKKYKLDSSKYCPKCRKHTEHKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3F9</accession>
    <name>I2F3F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0747"/>
    <dbReference type="EnsemblBacteria" id="AFK06462">
        <property type="protein sequence ID" value="AFK06462"/>
        <property type="gene ID" value="Theba_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0747"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="105" mass="11442" checksum="42D177993B02316A" modified="2012-07-11" version="1">MKIAVPVKEKSMNSIPDDRFARAKYFLIYDPETGNEEYIEPDNSVAHGAGPMAVNMLTKKGVDALIAFHLGGNAIQAIEAAGIAFYEAFVGTAKENIDAVLRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J2</accession>
    <name>I2F3J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730549.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0781"/>
    <dbReference type="EnsemblBacteria" id="AFK06495">
        <property type="protein sequence ID" value="AFK06495"/>
        <property type="gene ID" value="Theba_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0781"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017878_0_2_0"/>
    <dbReference type="OrthoDB" id="942962at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="368" mass="41391" checksum="ADC71F76B728C591" modified="2012-07-11" version="1">MKCGGCGAELQHDDPAGLGYISRSVMESRLQSGKQVLCRRCFLIKHYGSLSEDDRVVHSIDNLKEYLDLAQDVIYVIDISDFDGTCRRDILRLLKEHTVHYILNKIDLLPREVKIDEIRDWAASMLKVPKETVRPVSVLKNHGLKSLFSYLKSASEEFVSVGVTNVGKSSILNGLIQSEELTVSRFPGTTVKVASKKVGGSAFTVYDTPGIFTKDRITDLLSVEDQSRFLPRKKLNKSTIQFHDVRTVFLGGFVRLDVKNESDPVGIFHVFVPESVTVHETNSDTGNEEWDRWYGGILKPPFSESIRSNYKWKSERFRLITGQELHIFGMGWINVAKGPLTIAVTTPEGVATKVRKGLIGAKKFKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R6</accession>
    <name>I2F3R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_0859</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730608.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0859"/>
    <dbReference type="EnsemblBacteria" id="AFK06569">
        <property type="protein sequence ID" value="AFK06569"/>
        <property type="gene ID" value="Theba_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0859"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_1_0"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="166"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="302" mass="34619" checksum="32AE110BD8DCED15" modified="2012-07-11" version="1">MLDMYVACIGNFDGVHLGHRAIMQKTVNIAANLDLQSTAISIVYPWGYYFPNFPGIIYPVAQRLELILATGIERVLTVNMSEIRYLEPEDYISRLMSEGMRAIVVGSDFTFGNGAKGNIELLERISKEGDLRVEIVPDALYDGRRISSSWIRESIAKGDIGLTNSLLGKRYSIRGKVYKDKQLGAKIGFPTANIHRGDERLVIPRSGVYIIMSTIDSRDYFGLLNVGFRPTVNTSEEVKYEVYFFDYSGNLYNRNLELEFLEFIRPELKFDSLGELIEQIKHDERVARRWLEIHLNMLKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W0</accession>
    <name>I2F3W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">K+dependent Na+ exchanger related-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492609.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0903"/>
    <dbReference type="EnsemblBacteria" id="AFK06613">
        <property type="protein sequence ID" value="AFK06613"/>
        <property type="gene ID" value="Theba_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0903"/>
    <dbReference type="eggNOG" id="COG0530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_0_3_0"/>
    <dbReference type="OrthoDB" id="804531at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="175"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="318" mass="33204" checksum="335750A5B32B6B72" modified="2012-07-11" version="1" precursor="true">MLVSLLMLAAGFALLIKGADYLIEGSVAIAKNLGISELLIGLTIVAIGTSAPELAVSVQAAFKGSDIALGNVLGSNIANIGLILGITAILTPLGVNKTTMSYEIPFVIIITIASSALILGNNGLHRSDGIVLITFFLIYMMYVFTMAKRDRSITDIVEVEGKRDVEILEKSPVLAWVATIGGTAAVILGGNFVVDGGSSIAQIFGVSDMLIGTTIVAIGTSLPELVTTISAGRKNRSDLAIGNVVGSNIFNLLLVLGISATISPITAQRSLAAEIIFASLLAIVLPLLLLRKKKLDRPRGALLLIIYASFLVSSIFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W7</accession>
    <name>I2F3W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic component of amino acid ABC-type transporter/signal transduction system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730645.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0911"/>
    <dbReference type="EnsemblBacteria" id="AFK06620">
        <property type="protein sequence ID" value="AFK06620"/>
        <property type="gene ID" value="Theba_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0911"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_0"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="5">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="240" mass="26509" checksum="B67909C388932FB8" modified="2012-07-11" version="1" precursor="true">MKKALLVLLALLVSTGFGFGAKYVVGTSADFPPFEYVENGEFVGFDIDLIKAIAEEMDFEIEIRDMSFDSLIAALASGNIDIVISGMTITPEREEVVSFSKPYWTADQSVVVRDDSELTVTVLFGKHNIGVQTGTTGDLWVEDNLVKTKILTGDFKRYDTYVLAMTDLVNKNIDAIVLDAPVAESFAKVRPVKIVGVIKTYEDYGIAVNKSNKDLLNLINEGIARLEESGRLNELNLKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y6</accession>
    <name>I2F3Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730661.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0933"/>
    <dbReference type="EnsemblBacteria" id="AFK06639">
        <property type="protein sequence ID" value="AFK06639"/>
        <property type="gene ID" value="Theba_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0933"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_1_0"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="30784" checksum="A277353A02C0D223" modified="2012-07-11" version="1">MSFNVLMPTSEEELVSLLSKERSHILSGGTDLIVKIRLKRVIPKIVVSLKHLKGLDTIEDLGDKIRVGCRVTISELLKSEIIDRHGRIVQMALRQIGSPQIRNRATLAGNIVNASPAGDSIVAMVLTNASLSIGSANGERYERVVDFIKGPGETTLSRGEFVKSITFEKTDALFPQFYKVGQRNSMAISVASVGSLTSESEIRLAFGSVAPTVVVPIEACEYYSAKNGSFDEERFVELAMKCVTPIDDVRATAWYRTTVVRNLIHRTLKVWRKKGYNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F402</accession>
    <name>I2F402_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730676.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0949"/>
    <dbReference type="EnsemblBacteria" id="AFK06655">
        <property type="protein sequence ID" value="AFK06655"/>
        <property type="gene ID" value="Theba_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0949"/>
    <dbReference type="eggNOG" id="COG4635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094839_2_0_0"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="157" mass="17356" checksum="6DBDE88C951E79B5" modified="2012-07-11" version="1">MKTAIIYATRSGTAEKCSAKISEMLSGESTVVNIKKVSSPDLSGYDSVIVGASIRIGKVQKEISEFVQKNLETLKAKRLGVFLCMGAGEENFNEYLSQNFPKEFLDKCKSKGFFGGEFNLERLGFLSKMMLKAASKGKPQPHIIPGNIDRFVKDFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F420</accession>
    <name>I2F420_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0967"/>
    <dbReference type="EnsemblBacteria" id="AFK06673">
        <property type="protein sequence ID" value="AFK06673"/>
        <property type="gene ID" value="Theba_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0967"/>
    <dbReference type="HOGENOM" id="CLU_1738344_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="17514" checksum="7EA47A6BFDA37FB6" modified="2012-07-11" version="1">MTPKGVVFLNEEEQINNNPLETERDSEVKAVIRKYSIIAVIVLSVFLMVFSTRDRVEVFNPESVISTIEETLLLFINQRLVKVNEDVGFLEIVSSDYEEVEWGEYTYEIQTRFALSESVENLYTLWKYRVRDDTLDLLGYSSDGENWLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F427</accession>
    <name>I2F427_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492704.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0974"/>
    <dbReference type="EnsemblBacteria" id="AFK06680">
        <property type="protein sequence ID" value="AFK06680"/>
        <property type="gene ID" value="Theba_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0974"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520546_0_0_0"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="523" mass="57118" checksum="DF8BBABB2805FBF2" modified="2012-07-11" version="1" precursor="true">MHRRLSSLLLILCLVLVIALSGCVFRRYSVVVSCTPLIEKIEVGNRERELPYSFSARKGQNIVVKAPLVPGYDFEGWLINNELRQTAEIAVEIEENTTIKAIYSPRLVHEITYGGSGYENGTGLVVENSNEILIGITSSSTDSSLILENKGKSDFWIPFLQYESNNYVVEPQLCYGGSDEESLMDTVRIAGGYVSAGWSDSSDIAYSGSGYPYHGGTDGYVIMMHNDGSLRWQTYIGGSGDDEIRSVNTTIGEKLIITGITGSSDSNFANSGYHGSKDGWVALMSSSGTLITDLIKVFGGSAEDGLLYAMQTKEGGYIVCGYSTSSDGDLNSLSRSTGEDLWVLKLDSQLEIEWQDLFGGQNDERANVIKEVNDGYIAVGFTESAGGDINENKGGKDLWVLKFSSDGDLEWSKTYGGSEDDEGFDVVQTADGGFAICGYTDSSDGDILHENRGMSDVWVIKLGYDGYLEWEATFGGSENDFARRINETEKRELIVIGTTSSSDRDIKRPIQGPSDAWLLRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F458</accession>
    <name>I2F458_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730722.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1006"/>
    <dbReference type="EnsemblBacteria" id="AFK06711">
        <property type="protein sequence ID" value="AFK06711"/>
        <property type="gene ID" value="Theba_1006"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1006"/>
    <dbReference type="eggNOG" id="ENOG503471U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2058600_0_0_0"/>
    <dbReference type="OrthoDB" id="1971665at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="119" mass="13027" checksum="51C0BC40ABD4E3C2" modified="2012-07-11" version="1">MADRAIKCSANSLDFAQKVAGFSAKAVELKAPFSGRPEAHRNQHDLYVVISGKAKVKTGELTGKVDEISEGEYRSDEMIVNEEHTLQIGESLLIPAGLAHTVIVESGVFAQWVFKIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F472</accession>
    <name>I2F472_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730735.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1020"/>
    <dbReference type="EnsemblBacteria" id="AFK06725">
        <property type="protein sequence ID" value="AFK06725"/>
        <property type="gene ID" value="Theba_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1020"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_4_4_0"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="523"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="576" mass="64392" checksum="977D293D6AC63A7F" modified="2012-07-11" version="1" precursor="true">MRKLLALILTVSVLTMAMASYFHLTILHTSFVPANTAPFDYSSGKSEDVFPARLAVFVNQMRLFNPNTLFIDTGNLIRGTPLSYYSAKIDYCNLNPFVEAMNAIGLNASLIGSEEFIYGPGFLEEAISASEFPLLSANIVFKSSGEPVFSPFEVVEIEDDGEKLRVGIVGLVTEVIPPWQEAEFFAGLSFVDPVDAAGDYLGKLREEVDVLVLAYRGSNEEAHEIMKALREIDVFLKGPQLTTKSAIVDGVVISGPGYIDESVSKIDIYLEKTGEDWKIYDRSVDEISMSGFLPDESVVEIFRGYNDQIQKLLDTRVGFAVGDFYVEDALEARLRDNPLAEFINRVQMEVTGAKISCTSIFDHATTGWKTGPITIGEIYEVYPVPSTLKVLELTGEDIKEALEFNAERFVTDDGLLTLDHWSVDDYSNYDMWEGIEYIIAIDRPVGERVLSVWHNGKPLDMAETYEVSMSSFRAGGGGYSMFENKPVVRDVKLQIFEIITDFVQERFAISPQVDNNWSVGTGFIHTVGWNETLRSISEMYDIEDSEIMKYNPDLVGVKSIPAGSELIVYRPFFQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F477</accession>
    <name>I2F477_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730740.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1025"/>
    <dbReference type="EnsemblBacteria" id="AFK06730">
        <property type="protein sequence ID" value="AFK06730"/>
        <property type="gene ID" value="Theba_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1025"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896607_0_0_0"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="51"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="35127" checksum="20BACA386364EC9C" modified="2012-07-11" version="1">MKPQNFVVINREIERRFVEEKKKNPDRFERKLSLSWSIWMFGTEPIEDSLRRLQNNGLEYVEIKGDTSISRERMKHALVSFGLRVSGACGMFSPERDLSSLNPDYQKNAIDYIREVSRYVSGIGGTYMIVVPGAVGRPKAVDNFEMERSAAALKKCAIIFEETGVKPAIEPIRSAEVSIVHTIDEALEYLRFVNEPSIGFVNGDIYHMLNGERHVGEAILKCGEKLLNLHIADSNRDAPGKGQIDIDTAIMAAYLVGMNREGRFITFEPLGPYPDPYVLSTGPCDVDLMDRLVRESVDYFREREEVVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>I2F492</accession>
    <name>I2F492_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ORF">Theba_1040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1040"/>
    <dbReference type="EnsemblBacteria" id="AFK06745">
        <property type="protein sequence ID" value="AFK06745"/>
        <property type="gene ID" value="Theba_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1040"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="150"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="534"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="588" mass="66906" checksum="33B655B2E0796BA2" modified="2012-07-11" version="1">MKKRTHTCGELRASDTGTVVTLNGWVDRIRDLGGIKFVQVRDRYGFTQVVFDPQDNELYNMALKLGNEFCISVTGSVRKRPDDAINLRLPTGEIEIVASEMGILSDAEVPPIYINIDEESAEEMHLRYRYLDLRRPKMQRNILTRHRFVQAVREYLNNNGFVDVETPILGKSTPEGARDFLVPSRLKAGKFYALPQSPQIFKQLLMVAGFDRYYQIAKCFRDEDFRADRQPEFTQIDLEMSFADEEDVFSMTEGLMKYAFEKAASADISTPFRRFTYQEVVEFYGSDKPDTRYGMKIHDITSIFEKTAFKVISDSIDKGEKVKGFIVENKADRFSRKKLDEYTAFAKESGLGGLMWLKVEGDGLKSSILKHCPEELSSLVSLFAANENDLILFSLGEGLPLSKALGQMRNKIIKEEEFSVEGFEFLWVTDFPMFSYNEEEQRIEAEHHPFTMPDLEDLEKYGESDPLKVRSKAYDLVLNGYEIASGSVRIHRRDIQSRVFDLIGLSREEATEKFGYLLEAFKYGPPPHAGIAPGLDRIIAIIVGAQSIREVIAFPKVASGADLMTSAPSEVSQKQLDLLKLQLKDTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F497</accession>
    <name>I2F497_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06750">
        <property type="protein sequence ID" value="AFK06750"/>
        <property type="gene ID" value="Theba_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1045"/>
    <dbReference type="HOGENOM" id="CLU_2569830_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="81" mass="8836" checksum="3D31D65BBC103B3B" modified="2012-07-11" version="1">MSVLLPSRHPDNAPGQDPCPSRKRDVRRIVSPYFRSRLLVSEANSRTYAFSALVSVQRSAKSGSLMGDPVQEHNGMTAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4D3</accession>
    <name>I2F4D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730784.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06786">
        <property type="protein sequence ID" value="AFK06786"/>
        <property type="gene ID" value="Theba_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1081"/>
    <dbReference type="HOGENOM" id="CLU_2717699_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="72" mass="8204" checksum="3D267BDEB88695BB" modified="2012-07-11" version="1" precursor="true">MTEEEFVGADSTGCQYYSLHVILTMLLVRISVFAVFSRPDPVQKHHGMTEEARKRDHRSRQSLFSLAAFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G1</accession>
    <name>I2F4G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM domain-containing protein,prolyl oligopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730811.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1109"/>
    <dbReference type="EnsemblBacteria" id="AFK06814">
        <property type="protein sequence ID" value="AFK06814"/>
        <property type="gene ID" value="Theba_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1109"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048353_3_0_0"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="333" mass="35714" checksum="795981B242B64BEC" modified="2012-07-11" version="1" precursor="true">MKVTRRASLVVLLIVLLGGMLFAAGSEYTVVKGDTLWEIAKAYGVDWKEIAELNGITDEFALQVGTVLKIPEAYTEISVMIPNIDHEIPAVICIPNGDGPFPLVVMLHGTGSDKNEAGGGYLLAAPALAKAGIASVRFDFIGNGESTADYINYNFTSAVDDTNIAFAYAASLPRVDGHRAGIMGWSQGGTIALLAAGQNPAYKSVLCWAGAPDLSGVGSLEAYEIAKQNGYYELTFEWRSPLKLGLQWFDEAYGTDVLQVFSNSSAPVLAINGSEDTVVDPVNAQRIVDASRNEKSKVLIIEGADHTFNIFTGDMTAFNQLIEATVDWFSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H3</accession>
    <name>I2F4H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06826">
        <property type="protein sequence ID" value="AFK06826"/>
        <property type="gene ID" value="Theba_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1121"/>
    <dbReference type="HOGENOM" id="CLU_1667324_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="158" mass="18087" checksum="74E91A9969A43D31" modified="2012-07-11" version="1">MLSLRSSSFIRKADRHEVSTFSLTATIIVVKSFLRIQVIAYISTTDHRSRSVPIFRSQRLAISVKRVFDGRSRIGALRDDSKGESRDGTLKRHPDNAPGQDPYPSRKRDRPHDPVSPYFRLQRLAFSEKRVFDGRSRTGALRDDRPLSKARTDFSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4H8</accession>
    <name>I2F4H8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730825.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1127"/>
    <dbReference type="EnsemblBacteria" id="AFK06831">
        <property type="protein sequence ID" value="AFK06831"/>
        <property type="gene ID" value="Theba_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1127"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_1_1_0"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="276" mass="30296" checksum="199F89DFB1211DF9" modified="2012-07-11" version="1">MNDNYKDEISQKVARAYEQIAKTHCSSKSYSLGHIKLKTIELIHLIRKTFCPQLSHTRPVNGEELLLEGLNTLREMIIEIRPELGEEGAGQVVKEFLAELPSVALTLVTDVRAAYEGDPAAKSVEEIMIAYPAYEAISTYRLAHILYKLDVPLIPRIMTEYAHQKTGIDIHPGAAIGNYFFIDHGTGVVIGETCTIGNHVKIYQGVTLGAKSFELDENGNPIKGIKRHPDIGNHVVIYAGATVLGGNTVVGDNCVIGGNVWLVHSLKPGEKIYNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4K1</accession>
    <name>I2F4K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486457.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06854">
        <property type="protein sequence ID" value="AFK06854"/>
        <property type="gene ID" value="Theba_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1155"/>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058017_0_0_0"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="402" mass="45221" checksum="31573F2728EAB553" modified="2012-07-11" version="1">MVDLQPFFEIQERLFSSVPTEFKRYAYELIDWNDPLLGIVGARGCGKTTMLLQKILEKGQKGFLYISGDNPLVLREGIYAIGDTFFKLGGKTLVVDEAHRQPGWANDIKALHDSYPGKQIHFSGSSRYSVMKGTADLSRRAVLSELRHLSFREFLNLEKGENFPAVSITELLENHINISRKLQKLHPLELFREYLRAGSYPFRLSYGSYYERILNTLDKAIYQDVVEQDSLRGEAATIIKKIIAFVATSVVPSISPESLCKELGISKVTLYTYLDSLERAGVLKRVLPCGRGIKGMRSGSKVFLGETNLYYALGLPQWNLEANMGTIREAFFVSQVGHLGICVPASGDFTLKEKNKEITFEVGGPDKGRRQLKDSSNGFVLRDGIEIGFENIIPLFLFGFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L1</accession>
    <name>I2F4L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1166"/>
    <dbReference type="EnsemblBacteria" id="AFK06864">
        <property type="protein sequence ID" value="AFK06864"/>
        <property type="gene ID" value="Theba_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1166"/>
    <dbReference type="HOGENOM" id="CLU_1711086_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="17513" checksum="AB85FD95054A34C1" modified="2012-07-11" version="1">MKRRTRSRAGTSRDDRRNVHQGRLYGMTPFHVILTMLLVRIWSFGFYEACTRKNGTDAKGPSVPIFAYSAQRFLGTRSRTGALRDDRRGAHQGILTKLLVKIFVYIAKNGTDVRRIVSPYFRLVIQMRNLWAYSEDGGPLTENVVFTAVSRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M3</accession>
    <name>I2F4M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1178"/>
    <dbReference type="EnsemblBacteria" id="AFK06876">
        <property type="protein sequence ID" value="AFK06876"/>
        <property type="gene ID" value="Theba_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1178"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_19_0_0"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="338" mass="37725" checksum="9A6AADF7E65A07ED" modified="2012-07-11" version="1">MVSGLELPKVSVIIPARNEEKFIEKCIESFLTCDYPGELIEVIVVDGMSDDRTREIVGEISRRDDRVLLIDNERKITPVAMNLGVKTSKGDYIFFSGAHSEIPSNYITKCIKHAIETGADNVGGVMKTEPRVRSAVGIAISKVLSSPLGVGGAKFRTGVSKPTEVDTVPFGCYKREVFDTIGYFNEKLVRNQDIEFNLRLKRAGGKIILFPDIELTYYSRSTLEELWKNNFGNGFWVIAAKKYAEVPYSTRHLVPLMFVLFLLLGSLISLIVSAFQFVYVFLLAFYVVAVVFFSISHAMEAKMADVFFAAIVSYPVLHISYGIGSLLGFLSFLFGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P6</accession>
    <name>I2F4P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C_GCAxxG_C_C family probable redox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730887.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1202"/>
    <dbReference type="EnsemblBacteria" id="AFK06899">
        <property type="protein sequence ID" value="AFK06899"/>
        <property type="gene ID" value="Theba_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1202"/>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091283_5_0_0"/>
    <dbReference type="OrthoDB" id="2083729at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="142" mass="16212" checksum="662755D00C47B0C9" modified="2012-07-11" version="1">MLEDAVGKQYSRNDAERNCAEAMVYGANDEYGLDLPQEAFFTMGAFGGGMRIKSICGAVTGSLAVLGILFNSEIYEKQERMKRIAEEFIAEFEKRYGHLECSVLRDKYRDPVIGCETTVRMAARVLEEIIQKYRREITYRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T0</accession>
    <name>I2F4T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-binding protein containing Zn ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730914.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1245"/>
    <dbReference type="EnsemblBacteria" id="AFK06933">
        <property type="protein sequence ID" value="AFK06933"/>
        <property type="gene ID" value="Theba_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1245"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160523_3_1_0"/>
    <dbReference type="OrthoDB" id="2081772at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="98" mass="11472" checksum="5C97F96F768F31D0" modified="2012-07-11" version="1">MKWNHRTIGQIFNDLAKSSSLFRKIRVFELNKDWGEIVGEPIANHSSIVDFSEGTLIIRVDDGMWLNEMKLREKILLERMNSSLGVEAIKRIRFRIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U3</accession>
    <name>I2F4U3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ORF">Theba_1258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730927.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1258"/>
    <dbReference type="EnsemblBacteria" id="AFK06946">
        <property type="protein sequence ID" value="AFK06946"/>
        <property type="gene ID" value="Theba_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1258"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_2_0"/>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="228"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="499" mass="56075" checksum="4C594FB677B89428" modified="2012-07-11" version="1" precursor="true">MVLVLVSAVLTALAMPGMLWGYLIWVALIPLFMAMKDVSPLKGALRAFVWGFVYLLLTHYWLLPVLTVNVPEVLNSFPNFIGVVVFFLMGIVMAVPFLVFGLVYGLYQRFFDRYPVLLALFAASFFTVTEYLREIGPLGFTNGRLSDALLNGQQGISQLLTIGGPLLLVFIIVFVNHYLCYLFVNRTRDRAILIVVSVAIVALVNAAIAALVPIPHSSSKYESTLYALQTNISMQMKYYQPPDETLAVVSRALREIPEGSVVILPEATFMSDIRRNSTGTQLQQIAQERNLKILIGFPTYNDHNYNQVRFVTAEGFSDEYYAKIQLTPFVESLPWPKVFGVFSFLKFLDFFDAGEEFTIFSVDEHRIGAQICFDSLYSNVARGLTLNGANVIVTATNDGWFDISTALNQHFSKSIARAIENRRYVIQVSNTGISAIIDPYGRIVKRLPTSKELNADYVIGEFQYIPTVKTTLYTRFGNWFFWFSLFLGIALIILGGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4X9</accession>
    <name>I2F4X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730958.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1294"/>
    <dbReference type="EnsemblBacteria" id="AFK06982">
        <property type="protein sequence ID" value="AFK06982"/>
        <property type="gene ID" value="Theba_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1294"/>
    <dbReference type="eggNOG" id="ENOG5030KYD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129275_0_0_0"/>
    <dbReference type="OrthoDB" id="2039235at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="165" mass="17876" checksum="47AE969C87C55ED6" modified="2012-07-11" version="1" precursor="true">MEEENVKKETAKKGSGLSQIFLGLIVIALGLVIIFVPAVLSNFWLLFIWLPGVIMEYNAFRNRNNGLLVPGGILLVVALALTLGVIFPGFYSQGGWGLFVLAPAFGLLQLYLADGRRHFGLLVPIAILTAVGVIALIPSSLSQWTMIVVGAVLIVFGLLVLFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y0</accession>
    <name>I2F4Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730959.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1295"/>
    <dbReference type="EnsemblBacteria" id="AFK06983">
        <property type="protein sequence ID" value="AFK06983"/>
        <property type="gene ID" value="Theba_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1295"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="280" mass="31668" checksum="4CE4B91D858D7858" modified="2012-07-11" version="1">MIVSVDKLRKSFSSKPVLNDISFNVEQGDIFAIVGPNGAGKTTTLRCIFGEIAPEGGELTVFGEKVTSRIKEKIAVMTEDRLTFRRFLGEDYLRMWRMLYPGWREKVFTSFAVHYKFNLNERVETYSMGMKTLFHIALTVASGADLLILDEPTQSLDPVIRQEVMGVLRDYVLQEGKTMIISSHEIYDLEEIAGSFAVVLEGKVLYSDTIDGAKETHRIIPKGQTIPSGEIIGVTGEETLVRTDEEAGRFPNFKEIVLCYLQSKKAFAPFEEEFKPRFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F535</accession>
    <name>I2F535_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_1350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486769.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1350"/>
    <dbReference type="EnsemblBacteria" id="AFK07038">
        <property type="protein sequence ID" value="AFK07038"/>
        <property type="gene ID" value="Theba_1350"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1350"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_0_0"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="503" mass="54831" checksum="17792E864DF8DB77" modified="2012-07-11" version="1" precursor="true">MLLAIIYFLLILTGIVVVHELGHYIFSRLFGVRVLEFAIGMGPKLWSKKGKNTTFRINAFPIGGYVRPAGEDLDTIDSSIPESEQIQNKPAWQRFIIYFAGPAFSLLLGFLILSLVAVIWGFQEVKIDKVEPGSPAAVSGMMPGDRIVSVNGKTLIDNTRLSEAVAKGERIDLVVNREGKEIEIAIIPELLPQEAFFVIGGVSGEPGDILSSINGGTFNGDYVGYGSVLSPESSIKLGFEDGSTLSGTLLTYSPAEERYAMGIYYANFKPQLAIDHGQFREGDILLSVNGMKTETSYDLTTMSQLLALKPDELLIQFTGKEISFAEFGFPDEFVVSVEREGQLINLTVSKNEMIALVEEAGAFAQGSSYWYPDTALEAVGLGVQWANNLLIALVKVVGSLFTGGANINEFTGPIGLVTIVDQAVSLGLRIVLYLAGFISLNLGVINLIPFPALDGGRMLLALIEMITRRRLDPKIEGLINVIGFMVLMGFMIYITFIDIGRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F544</accession>
    <name>I2F544_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730993.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07047">
        <property type="protein sequence ID" value="AFK07047"/>
        <property type="gene ID" value="Theba_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1359"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771188_0_0_0"/>
    <dbReference type="OrthoDB" id="731668at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="130"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="359" mass="38416" checksum="979772AFAC1DDE71" modified="2012-07-11" version="1" precursor="true">MMRTCGSKGLAVAGLLLGIGLLLIGIAVILRPEIARFGMSSDWSITGIKFTRSFTETITENTKFIEVETINGKVAVTGWDKDYIEILVEQSIWVSNEDLEDKYLKKTTPVISIEEGKLMIVTPVLQKTNELRGQGASIYLSVPKKHLEDIKVRTSNGAMTFKSIAASISGRSSNGGLELISASGAVTLETSNAPIFVEDSAGTMELRSTNGSFNGRRISGSFVIETSNAPVTIEDGDLNLSVSTTNGAITITESTLFGSENYLKTSNARILCDALLPETGVFEIMTTNGQVNLLVDDSLKAEFDASTTNGSVNLKDLMVAVTSSTSTSMKGNLNGGNGLLITLKTSNSNIMIENRRSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F7</accession>
    <name>I2F5F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maltose/maltodextrin transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_1477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731093.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1477"/>
    <dbReference type="EnsemblBacteria" id="AFK07160">
        <property type="protein sequence ID" value="AFK07160"/>
        <property type="gene ID" value="Theba_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1477"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_20_1_0"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032605">
        <property type="entry name" value="DUF4896"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030156">
        <property type="entry name" value="MalF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035277">
        <property type="entry name" value="MalF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032550">
        <property type="entry name" value="TM_PBP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47314:SF1">
        <property type="entry name" value="PTHR47314:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16237">
        <property type="entry name" value="DUF4896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16296">
        <property type="entry name" value="TM_PBP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="342"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="580" mass="65647" checksum="D8C555667119C413" modified="2012-07-11" version="1" precursor="true">MSRKRFVIFLFSLAILAIFNAFSLWSVYLLFADGNFGLMVTMIVLTLLIDIIALNPKGYPYRYMIPAMILLFILTLYPMYYTFRTAFTNYGTGHLFTRQQSIQKLLSDYFYIPESPEEFEFSIFIELDDYKPTDRFITLLKSKETGALFAAPRPQPVTKDAEGNITLATAKMVQVSGDSFSTGGVSYTLSISPDDKILAIRATSGERFIYFYSPQDDSTRPNAPFYFSEIRGIWLRNAEFTDSEGNQVRLFPNSLYTTFATTERKYALRTETTFDAGRAVQETVVYNRQTNRTLVEEGGFFYDIDENGNEFAVEGYISDVGFWNFVRMFRDPKISGPFFQVFGWTFAWAGLSVLFSFTIGLALAITLNDKRLKGKKIYRTLLIIPWAVPAFISALVWRNGFFNETYGVLNRFIIQGLFGLEPIKWLNDAFWAKVSVLLVNTWLGFPYMMTVSLGALQSIPEEFYEASSIDGATKFQRFRKITFPLLMVTVAPLLVGSFAFNFNNFTGIYLVTQGGPAIVGASTPAGATDILISYTFKLAFEGRGQDFGFASAISILIFIIVAGFSWINFKLSGSFEEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I6</accession>
    <name>I2F5I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">nnrD</name>
        <name evidence="10" type="synonym">nnrE</name>
        <name evidence="13" type="ORF">Theba_1507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731113.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1507"/>
    <dbReference type="EnsemblBacteria" id="AFK07189">
        <property type="protein sequence ID" value="AFK07189"/>
        <property type="gene ID" value="Theba_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1507"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_0"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Ribokinase-like"/>
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        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
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    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
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            <begin position="54"/>
            <end position="58"/>
        </location>
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            <end position="131"/>
        </location>
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    <feature type="binding site" evidence="10">
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            <position position="55"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
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        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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        <location>
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        </location>
        <ligand>
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            <begin position="405"/>
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        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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        <location>
            <position position="434"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="495" mass="52792" checksum="C4A68C866A5FBF3A" modified="2012-07-11" version="1">MRVAFPDQMRKIDKTIIEHGVPSLLLMEEAARSVFEEIRSFNLSNAVVLCGGGNNGGDGYTVARLLLCAGVHVKVVQCYVPSTVDCKANSTLYSSLGGQITIIGEKTDVEELLSKADIVIDAVFGTGFHGELESGVAQIFDFVNRLDVIRLAVDIPSGVSGFDGSISKSCFRAHKTVTFGLAKTGHFLYPGREFCGDIVVGSAGFPKNVMDSLAEPEVIDDEMVSKLIPERAPNSYKGTFGSVLVVGGSNIYTGAPYLSALGAFRSGCGMVYTYTPKGSATVIRNNLPEAIAYESRGDFLIPGDIEVLPKIMEKIDSIVVGPGAGREKESIEFILKLLQSFPDKNFVVDADGLYALSNDLSVLARSERIIITPHIGEFARMNEGKTDLKSFIQFCVGNRTTAILKGASSVLCDDKGKITINTTGNTGLAKAGSGDLLSGTIAGFASQTGELTKSAILAMYFMGRAAELSIVSEPCNSASQIAESYSLVFKELEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    <dbReference type="OrthoDB" id="1964193at2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="12593" checksum="5AFF702B526FCC3D" modified="2012-07-11" version="1">MSAEVMILAFEGKKACFLHALLNALDMSEKGIEVAIVMEGESPSLLKEIVNETDALHGLYSEAKRKGLIKAVCYGCSKLMGVLEIVEKEGLPLNGSMKNHVPLAPYVERGAEIITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5N6</accession>
    <name>I2F5N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
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                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFK07239"/>
        <property type="gene ID" value="Theba_1567"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2155335_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="111" mass="12951" checksum="38454CC9EFED49C9" modified="2012-07-11" version="1" precursor="true">MFFTLAVIIAVVVVAFLIKGLSEKDEVAKREEEREISFSQHAVQRMDERGIETDRVIRVLEEGIRVQIANYNRLKVSDDEMTVILEKRLDNFEVITVYWNDDDHKDADLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P5</accession>
    <name>I2F5P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
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            <taxon>Thermotogae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731155.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1576"/>
    <dbReference type="EnsemblBacteria" id="AFK07248">
        <property type="protein sequence ID" value="AFK07248"/>
        <property type="gene ID" value="Theba_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1576"/>
    <dbReference type="HOGENOM" id="CLU_181383_0_0_0"/>
    <dbReference type="OrthoDB" id="2032133at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36443">
        <property type="entry name" value="PTHR36443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="79" mass="8921" checksum="AD4058B36FB70071" modified="2012-07-11" version="1" precursor="true">MISPEAFEKLLVKVGLLCLAIALLLFIFRKAGLSLGRLPGDIHVSRDGFEFWFPITSGFVVSVCITGILWLWKFISKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Z2</accession>
    <name>I2F5Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1685</name>
        <name evidence="7" type="ORF">Theba_1752</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MesG1.Ag.4.2</strain>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1685"/>
    <dbReference type="EnsemblBacteria" id="AFK07345">
        <property type="protein sequence ID" value="AFK07345"/>
        <property type="gene ID" value="Theba_1685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07408">
        <property type="protein sequence ID" value="AFK07408"/>
        <property type="gene ID" value="Theba_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1685"/>
    <dbReference type="KEGG" id="mpg:Theba_1752"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787098_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="126"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="250"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="352" mass="39085" checksum="2423A67EC2EAE974" modified="2012-07-11" version="1" precursor="true">MTAISVFLILSVQRLFSREVVLAKAKPSLAAMILAFWPASAAHWLPFPSCEAASLPRMILRASLPPGSFGASLPGMLFPASLLNGVGIAPADVFQRFSIHLHSIYNRNAGSTRTGHGHSEVIRLLRILLVEDDENLANGISYALTQEGWATTLAGSVSYALEMLESGDFDLALLDVMLPDGNGFELCKKIRERSEMPIIFLTARDEEVNIVMGLESGADDYVTKPFRLRELISRIKANARRIQKRSVEEGGSLKSGPLELNTSKLRAYRSGKEIILTPTEFKILRTLMENEGIVLGRDRLLQKVWDVDGEFIDDNTLSVHIRKLREKVEEDPSKPKLIETLRGLGYRWNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F614</accession>
    <name>I2F614_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731260.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07367">
        <property type="protein sequence ID" value="AFK07367"/>
        <property type="gene ID" value="Theba_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1710"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_1_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="49056" checksum="03B896845773C2A8" modified="2012-07-11" version="1">MKYYSLIDKVYLEKNLLKAYGRVKSNRGAPGIDGVSVETFGEKLLEEIERLSGEIKRGEYKPMSLRRVEIPKADGKTRQLRIPAVRDRVVQQSLKEVLEPIFEEGFHPSSYGYRKGRNAWQAVEKAKAFASKYGLCNVVELDLSECFDTLDHEKIIDSVAERVSDGKILKLIRAILKSGVMEDGVWKATETGSPQGGVISPLLANIYLNEFDQKMKARGIRIVRYADDILIFSKTQEEAREFLAIAINILEIDMKLKVNRNKTRITTLEDGFHFLGFEIKGERVGIEKSRLKRFKEKVRKLTRRNQSRPVKEIVKQLNPLLRGFASYFRIVDFQSILRGLLSWIRRRLRAIILHQWKTTKKLNRVLRRTGWKEKVNMRMNKWRSSHSKAANYAIPNRFFEEMNLVDMTKYHHPLSKFPILDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F624</accession>
    <name>I2F624_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1643</name>
        <name evidence="5" type="ORF">Theba_1720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
            <strain evidence="5">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489297.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1643"/>
    <dbReference type="EnsemblBacteria" id="AFK07306">
        <property type="protein sequence ID" value="AFK07306"/>
        <property type="gene ID" value="Theba_1643"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07377">
        <property type="protein sequence ID" value="AFK07377"/>
        <property type="gene ID" value="Theba_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1643"/>
    <dbReference type="KEGG" id="mpg:Theba_1720"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="37114" checksum="B69E1263D34CDE87" modified="2012-07-11" version="1" precursor="true">MGAYFRRKIIIYLLTFVFAVTIDWMIPRFMPGNPITNLLSRFSTRSDTTEVIAGYLNEIYGLDKSPLHQYFAFWAGLFRGDLGVSLYVTGAPVTRVIARALPFDLALLIPAIMLSYIAGNKFGAFAARKKKLDGIVLPIWYVLTATPYMWLGILLAWFFGVALDVLPIAGAYSFSMVPNWSWTFIWDFLKHWILPFSSLFLVQFGGWAIGMRNMIIYELEAEYSRYLESLGASGRLVRQYAYKNAVLPQITGLALQLGVIVAGALATEVVFSYPGIGHLLKEAIMNQDYFLIQGCFLFIIVGVLLANIILDIAYILIDPRIRHTAEGETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F635</accession>
    <name>I2F635_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1654</name>
        <name evidence="3" type="ORF">Theba_1731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731212.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1654"/>
    <dbReference type="EnsemblBacteria" id="AFK07317">
        <property type="protein sequence ID" value="AFK07317"/>
        <property type="gene ID" value="Theba_1654"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07388">
        <property type="protein sequence ID" value="AFK07388"/>
        <property type="gene ID" value="Theba_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1654"/>
    <dbReference type="KEGG" id="mpg:Theba_1731"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_0"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="34972" checksum="2F1BD0D89D1BC25B" modified="2012-07-11" version="1" precursor="true">MSRSVLVLGDVNVDIIGKFDGFPTPGSCAYSEKPALRPGGSGLNTYVGLRKLGIDADFFTMIGEDIFGDFIKAELLTLGIEFSPKISESYSTGVVFSLSTNNERTFFSFRRGAADVHITYEDLSGTSLDSGILYLTGVSVVEGEETFETFLRVVEETKSSGTKIFFDPNIRKTDLVSISRIEKIIPFVDVFLPAQDELKALFSKSDKFRFCSDLLSTGISDIWIKRGANGCSLFSKDSCFDFPAPRVTALECTGAGDAFNAAVIWGYVNNLEEKEIGIYGNIYAGISTERIGAATSYPYRKEMLESKHYKSIKTGVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F667</accession>
    <name>I2F667_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Formate/nitrite transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1697</name>
        <name evidence="8" type="ORF">Theba_1764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">MesG1.Ag.4.2</strain>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731251.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1697"/>
    <dbReference type="EnsemblBacteria" id="AFK07357">
        <property type="protein sequence ID" value="AFK07357"/>
        <property type="gene ID" value="Theba_1697"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07420">
        <property type="protein sequence ID" value="AFK07420"/>
        <property type="gene ID" value="Theba_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1697"/>
    <dbReference type="KEGG" id="mpg:Theba_1764"/>
    <dbReference type="eggNOG" id="COG2116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036896_3_0_0"/>
    <dbReference type="OrthoDB" id="1834167at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="281" mass="30147" checksum="DBE5A88E1AA63206" modified="2012-07-11" version="1">MERSVVSPSENAESFVEIGFAKTNLTIVKEFVLGILGGAFIAFAAQGSNVAIHTIGSVGLSKTLAGALFATGLMMVVVSGAELFTGNSLIVISCLQKKSKWVSMFRNWLFVYLGNFAGSLLIAYFVLHSGQLGFSEGLLGGYTIKIAAYKTGLSFESAFFMGILCNWLVCIAIWMASASKDIAGKILAIFFPIWLFITSGFEHSVANMYYIPAGILAKANEEFAKAAISLGVSAEQIANLNWGTLFTKNLIPVTLGNIVGGAFFVGTIYWFVYLKKGKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I6</accession>
    <name>I2F6I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731341.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1891"/>
    <dbReference type="EnsemblBacteria" id="AFK07539">
        <property type="protein sequence ID" value="AFK07539"/>
        <property type="gene ID" value="Theba_1891"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1891"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_0"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="152" mass="17597" checksum="25D20CC4B483237D" modified="2012-07-11" version="1">MSVGEVKKEDAAILEKNLRTISTRIRREGRKVLRDFPITPAQFDVLQVLFFNGEKRMSDISRWLGITKSTTTGLVKRLIDADLVERRRSDKDRRSYIIDISAAGKTLIEKVIDRRVEYLKSVMTEIKSDQVKELEVIVKNLLEIMDSKKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K4</accession>
    <name>I2F6K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07557.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07557">
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        <property type="gene ID" value="Theba_1909"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1909"/>
    <dbReference type="eggNOG" id="ENOG502Z8GF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610750_0_0_0"/>
    <dbReference type="OrthoDB" id="658869at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="441" mass="49368" checksum="2C6DD1A0F9343CEE" modified="2012-07-11" version="1" precursor="true">MKRFLVLFFIVFSVFSVAETVRVPVSVSSFTGEPIAVTISMSEILDLVGVDFDANWDSLRVVQDGEELPYQIDDTDLNGKLSSGDVMAFLITGPAEITVTDDFDILPPEFDAVGKVVEEEGQWLIEIGEITAVANSKGLVKVTGFGDVEGTIVDELGIVRMSGYVGSTYYVDGEYGRHEEKTSGDFIVKEATVLPAGPVGITVVSTLEAQPFLGITQKIITTLFSNGDIISHNTFEFATYAELMKLQIMATRVLTDAAEDTVHTLPVFRRLLWADQLNITPLEYWLDRNAIMFSGNKPYIVFPAVDSMRPLWWGATYIFASQESWRANYSQSLKTGVAEINPEVPVVVADYEEWMGGLTWVYESREFRDGYFEWMPGEIDIFESTKDYVSSNWEDYVKHFVAGDVVSFKRVYSIYSADSIEDSIEFVEMKKSEIQSLKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L1</accession>
    <name>I2F6L1_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07564.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_014731366.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1917"/>
    <dbReference type="EnsemblBacteria" id="AFK07564">
        <property type="protein sequence ID" value="AFK07564"/>
        <property type="gene ID" value="Theba_1917"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1917"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_1_0"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="67" mass="7684" checksum="E4A07ED8E62783A5" modified="2012-07-11" version="1">MKNRMKEFRFKNGEMTQDNIARMAGVSRQTIIAVEKGKFKPSVKLALKLANILHCTVEELFELEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M6</accession>
    <name>I2F6M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731381.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07579">
        <property type="protein sequence ID" value="AFK07579"/>
        <property type="gene ID" value="Theba_1933"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1933"/>
    <dbReference type="eggNOG" id="ENOG5033HB3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1923123_0_0_0"/>
    <dbReference type="OrthoDB" id="2175731at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="139" mass="16370" checksum="9E1797801F345631" modified="2012-07-11" version="1">MYTWMKTLGWINFTLLVINTSLFLTRWFYRTFNKRLERFPWKGFKKLMVVLAAVHPWTGSILLFTALYHGYLATGGFVLYSGSLVFIGVFAQFIVYLLGKYVSAMKKKWRPIHKGLMIATWALFLFHIFAPYSIWIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M8</accession>
    <name>I2F6M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Micrococcal nuclease-like nuclease</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_1936</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1936"/>
    <dbReference type="EnsemblBacteria" id="AFK07581">
        <property type="protein sequence ID" value="AFK07581"/>
        <property type="gene ID" value="Theba_1936"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082132_0_0_0"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="273" mass="30577" checksum="3CE9265B5BB12E48" modified="2012-07-11" version="1" precursor="true">MKKSVFIVLSLVFFFSFFFLQGCDRSKLTTTVTSVIDGDSITVKALQGTVRLIGIDAPEVTSGSKPAGQFAEEAREFLKQMVLNNGKVTLELHGKDSYGRHLAYLFNSEGEFVNAELVRQGLARPLTYEDTSHNSAKIREAYRQAFNNRSGIFSSYNDFQVYDASEVREALYPYQLGGFLGKIVWVEFTVIDVNGLTVVGDDIVVRVRPEEATLFGQDSKDLQRLYRKKIRVFGEIWQDDSGKVLMLLRDPAIEITGISQFANSSPFLLPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6N2</accession>
    <name>I2F6N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Mn2+/Zn2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731387.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1940"/>
    <dbReference type="EnsemblBacteria" id="AFK07585">
        <property type="protein sequence ID" value="AFK07585"/>
        <property type="gene ID" value="Theba_1940"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1940"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_0_0"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="29885" checksum="46C0736CBC50BF5C" modified="2012-07-11" version="1" precursor="true">MIQDFISDIISYSFLRNAILAAVLVSALTGIFSSVVVLRKIEFIGDGAAHATFGGIAFGLLLGTNYILMAAITAVIFAVAVSYFTRKNKLSESSVIGMLLPLSMSLGVIALSFIRGYTPDVMGLFFGNILMVTSEDVWMLLVANVIAWVFFAVFYRELLYYSYDEGMAKHYGVPIGFIHYAVLIGISLSVVGSVKIAGIILVTAFLVIPAVTSKTIARSFRGMILISLGMAVVASVMGIFVSYVLDMPPGPVIVVMLFMEFLITFSLKALFRVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V3</accession>
    <name>I2F6V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488033.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2013"/>
    <dbReference type="EnsemblBacteria" id="AFK07656">
        <property type="protein sequence ID" value="AFK07656"/>
        <property type="gene ID" value="Theba_2013"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2013"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_6_2_0"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="289"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="623" mass="69389" checksum="DE3CDAC57A9CE4C1" modified="2012-07-11" version="1" precursor="true">MTKLSDLSGFKRNLLLLVVDSLIVYFAYILGMYFRYGIFTLDEPEFFVNGIYFSAFIVVSLILNGVYRIAWSYSYFRDYFIILRAVIVGYAIGFLAGRFLNLFEIRFLTVPFTVSTMAAIISVFLLIWSRFFWLSILSRNHPIVSSEERVFIVGAGDAGTSIAEELSRHPENGLVVGFIDDSPKKLRKRIRGIPVLGNTDEIMPLVEKMGVRKVIIAIPSADASTLRRIFSKIDVSKVKAQTLPSITEIMDGKAKLGYLREINIEDLLGRESVQIDLNSLKDYVVGRTVLITGAGGSIGSELCRQIAPLGPGRLLLAGKGENSIYEISQEIGSLFPDLKVSQLIGDVADRSRMRYIFNKMRPQVVFHAAAHKHVPIMEENPTEAFRVNSLGTYNIASLADEFGVETMVVISTDKAVRPSSVMGVSKRIAEEFVRSISSRSNTKFGIVRFGNVLGSRGSVIPLFKKQIQSGGPVTVTDPRMTRYFMTIPEAVTLVLQAGAFSGDGDVFVLDMGEPVKISSLANEMITLAGYIPHQEIEIKYTGVRPGEKLFEELVLTNEELIQTKHPKIFRLKMNEAMDEEALLKTVSRLRTAVEESDFEELNRITSEIVDDSTARIDDGCDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y2</accession>
    <name>I2F6Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731465.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2044"/>
    <dbReference type="EnsemblBacteria" id="AFK07685">
        <property type="protein sequence ID" value="AFK07685"/>
        <property type="gene ID" value="Theba_2044"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2044"/>
    <dbReference type="eggNOG" id="COG3481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056349_0_0_0"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="180"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="345" mass="39118" checksum="F7E27483050979FB" modified="2012-07-11" version="1">MIDGKSGSYPVLSEILREYNSALDRVENYVNSKQGFFFIFSAKRIEGSRGPYYDCLVGDSKCRTEAKAWISEQGCLEPVEGWIGLADYLIDNRFGLSIKIRKLFSISEMESYSSGSITQLLPIVEDLEKIKSEVLELVESIKDKYLNTLVKRMVSDDGVCPDFFEAPAAKVYHHARIGGLAEHSLSVVRYALALREASNSRPNIDRDLIIAGGFLHDIGKTRTYITESFKFDYSDDGYLEEHIAIGARLIELEVSKISGFPEETRRKLMHIVLSHHGELQFGSPVTPKTREAILIWLCDNIDSRLDNFESHAFSASKESRWTDFSKMLQSRLYLGKIENEEEIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z1</accession>
    <name>I2F6Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731474.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07694">
        <property type="protein sequence ID" value="AFK07694"/>
        <property type="gene ID" value="Theba_2054"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2054"/>
    <dbReference type="HOGENOM" id="CLU_1794237_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="144" mass="16140" checksum="496FEF47B111552B" modified="2012-07-11" version="1" precursor="true">MGFFEGFSKIVFVISYVLWAGGGLTVSLLMIPMKDPRTEPQVQGYLHAFWQTIRIPAAALSFVVLGTAITMAIIVSASLLWSSLFSLSWFLTFLFWLMADRFMKSGGSDPRSMVEVHKRSFHAYLVIADISIFLSMLSVAFMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F725</accession>
    <name>I2F725_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731505.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2094"/>
    <dbReference type="EnsemblBacteria" id="AFK07728">
        <property type="protein sequence ID" value="AFK07728"/>
        <property type="gene ID" value="Theba_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2094"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="32069" checksum="CCDE55804F543466" modified="2012-07-11" version="1" precursor="true">MIQVCDLYYSYGKDEEFAVNGISFEVKEGEIFGFLGPNGAGKSTTQRILTGLLPVQKGKVRVMDVDFSATTPDFYNNIGVSFENPNLYLKLTGIENLEYFASLYDVPTEDPAHMLDMIGLKDVAKKRVGEYSKGMQQRLVFARSLINNPKVLFLDEPVSGLDPSTSAAIKELIKEKKKKGTTIFLTTHNMHIADELCDRVAFIVSGKISLIDSPRNLKLQHGKKLVEIEYRKNSSLKRESLSLVYEADRQKLNSLLDHEVIETIHSKEATLEEIFIKVTGEKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F756</accession>
    <name>I2F756_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ORF">Theba_2125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487830.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2125"/>
    <dbReference type="EnsemblBacteria" id="AFK07759">
        <property type="protein sequence ID" value="AFK07759"/>
        <property type="gene ID" value="Theba_2125"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2125"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_2_3_0"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="16410" checksum="1552BE533058F303" modified="2012-07-11" version="1">MWKEFKKFISRGNVIDLAVGIIIGGAFQVIVKSLVEDIIMPFISLFLGGIDFSNIFISLSGGTYATLAEAKEAGAATLNIGLFINAVINFLILAFVIFMIVRLINKIRERQKKEEAAAAPTTKICPFCHTSIPIDAIRCPNCTSELEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F762</accession>
    <name>I2F762_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731533.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2131"/>
    <dbReference type="EnsemblBacteria" id="AFK07765">
        <property type="protein sequence ID" value="AFK07765"/>
        <property type="gene ID" value="Theba_2131"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2131"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_4_1_0"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="32734" checksum="CEBF56E826EAB223" modified="2012-07-11" version="1">MWAFLDGEFVQEKERLVQLENRGLTFADGLFEVIRTLEGRILFFEDHYSRMKKSAEFFNIEMRFPSEEARRIAVELVKRNGIEDGELYIELTRGTDPHRDHRYPPKETRSTFFMLALPLRKIDSTSWRDGVKLLTYPDLRHGLCEHKTINLLPNVLAKNFAYARGGYEALMFRESNGKKYATEGGSSNYFFVKDGVFYTPEVDNILSGITRGKVISLVEDLGYEVVEKRIALEEFFNAEEVFLASTVSRVMPVRAIDDVSFEVCGKHTAKVMRAYEDLFFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F766</accession>
    <name>I2F766_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731537.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2135"/>
    <dbReference type="EnsemblBacteria" id="AFK07769">
        <property type="protein sequence ID" value="AFK07769"/>
        <property type="gene ID" value="Theba_2135"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2135"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="34402" checksum="B973983024F1C285" modified="2012-07-11" version="1">MAKFFYKRKLDEIEEKARPVHINSYKQLVWTKFKSHKLALFGAVVLIGVAFFTLLGPLFVEVGYEDMDFSNLFSPPLTEGHPFGTDELGHDVLVRVMYGGRISLFVGFASAVITTLIGTLVGLFSGFYGGIVDRLLMRFVDVMLSIPMFPILITLTLVFGSGIMNIILVLTVFGWMGVSRLVRGLVLSIRETEYVMSARAMGVRNGRIILRHVLPNVIPIVIVSATLNMSYAILAESSLSYLGLGIQPPMPSWGNMLQRAMNYILGTTAGTNPWWLTVFPGFFIFITVLNVNFLGDGLRDALDPKFVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C2</accession>
    <name>I2F7C2_9BACT</name>
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        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07825">
        <property type="protein sequence ID" value="AFK07825"/>
        <property type="gene ID" value="Theba_2192"/>
    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_3_0"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
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    </dbReference>
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        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="156" mass="16755" checksum="0E6C61861366C0F3" modified="2012-07-11" version="1">MIPEKVMAILKANDLEFYEFPEGTTPTAITAAQMLKVKVGQIAKSILFICKSGRAYLVVCPGDRKVSLSKLKKIAGEKPRLADETTTLQLTGFSPGSVCPFGLQDINIIVDLNLREYDVVFPAAGTSGSAVETSFEELVRITGAKVADVSNPMSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7C3</accession>
    <name>I2F7C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731589.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2193"/>
    <dbReference type="EnsemblBacteria" id="AFK07826">
        <property type="protein sequence ID" value="AFK07826"/>
        <property type="gene ID" value="Theba_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2193"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="259" mass="28706" checksum="E709F5BDEA0ECDB9" modified="2012-07-11" version="1">MVEPIQIEGLHFSYGKEEVLRGIDLHLKNGEVLGVLGPNGSGKSTLMSVICGIRKNWSGKISVMGDNLRGLSTKKLARIVSYIPQSFEPSFDLKVETIVSFGRNPHLNGLGNMTNEDYRIIEESMRLTEVYEFKDRPFSTLSGGEKQRVIIAKALAQEGKILLMDEFTTHLDPGHARRVGKIATDLVRAKGLSAIAIFHDINQAVEISDRLLFINNGRVIASGKVWDIVTPEIISLVYGLKSRIMENPISGLPLVVFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F2</accession>
    <name>I2F7F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731614.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2225"/>
    <dbReference type="EnsemblBacteria" id="AFK07855">
        <property type="protein sequence ID" value="AFK07855"/>
        <property type="gene ID" value="Theba_2225"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2225"/>
    <dbReference type="eggNOG" id="ENOG50337RT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969033_0_0_0"/>
    <dbReference type="OrthoDB" id="1638577at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032606">
        <property type="entry name" value="DUF4895"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16236">
        <property type="entry name" value="DUF4895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="289" mass="33732" checksum="815A1A784B5574C8" modified="2012-07-11" version="1">MTYYSGPESYREILRRVYEGVEDSFASWAKLVGDHSDRLDNAFGHFMTLVVQTSKRNAPVLSVFVDSEGRGYVGLSNSSPFETASALYRFPNEVENPFMEAFASFFGDETELTYHRAIFQSPLKLYFLAYYGNERLLRKEILKDSLRGKDYFRLSEVIDDTLFSICRENYRKWIEFDDGEVLVFPFQNILKIAFGLPKINENIDRSITMELSRLFRIEVTKQCDVLRNSSVTPDMNISRPVATVFEIDLVDSKPVYERLEAFYKYYSKFISETIESMLRFIHTDFPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J1</accession>
    <name>I2F7J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2265"/>
    <dbReference type="EnsemblBacteria" id="AFK07894">
        <property type="protein sequence ID" value="AFK07894"/>
        <property type="gene ID" value="Theba_2265"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2265"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_104_15_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="146"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="388"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="537"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="8">
        <location>
            <begin position="679"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="2">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="776" mass="87619" checksum="BD9D53AC27BC9AA3" modified="2012-07-11" version="1">MANGTERAFVGNLATTNHLIRENGLTNLRFTAFEAEKQLALHFAVRKDWPHLISIINKALDSITQEERIAINSKWIDLESEVDYGRIIRIISIFGAFVGVAMAVSIYWIFRLKKEVRKRELIQIDLERAKREAEDANEFKSSFMARMSHEIRTPLNAITGMAYLLKKTEISLTQSMYVDRITQASNNMLSIINDILDFSKIEAGKVELEITSFSMDQIIQDVVNIVSYKIEEQGIGFRLSKDPLIPNWFFGDQKRIEQILLNILNNAAKFTSAGEVSLDVRLVAKENEKYHLSFSVRDTGIGMTEEQIKNLFMPFIQGDSTINRRFGGSGLGLSIVKNLVEMMGGKIEVFSTPGEGSTFIIHLSLDVDKEREELYAKTFSATHFKNIRTLVLEKTGASMNLIESYLGAFGMHCELTTSQESAVSMLEAADGKFAKSFDLFILDYDTPSEGGFEFAVSIRNNKRIPKTPKLIMLLPMMREDLFDKLNDYGIDMGIGKPIIPSILLNGILDIFKLKAVSATHPSVKERVSQAKLERPHQVLLVEDNKTNQLIAKSILQQVGIESILAGDGKTAIELYSQHKEKIDLILMDLHMPILNGYEAAKEIRKMSTSVPIVAMTADVILGVKEKCEESGIHHYISKPFDPDHFIQTIKEIILENEEERIQESTVLDHSAGLKNIGGDIEVYRQILKAYLEENRETVEKLSLAINEKRYSDAAQIVHKVKGSSGSIGAKELHTVSMELQKALNEEKEDKIQPLKDRFSGLLRRLIEEIDRFHAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J4</accession>
    <name>I2F7J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731656.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2268"/>
    <dbReference type="EnsemblBacteria" id="AFK07897">
        <property type="protein sequence ID" value="AFK07897"/>
        <property type="gene ID" value="Theba_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2268"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357819_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="236"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="367"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="489"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="555"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="612"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="783" mass="87714" checksum="532EBA0503D9EF9B" modified="2012-07-11" version="1">MSVDSFDSASTKEPSNVILLEIGRNGLIEWMNEEAKSLFGAVRGESFFSLENKLTDCLKTEIIDRVFTEGALFSTTCSESQQISVTPVHTNDGGVERVVLSIAECEIAKVKLQSLQLKRELHLINKISKFMWEKDRSVSSLMIFLANELPNAMSYPDLASVKIICDGKEYLSPNFRETSLSSTYPIQSEKADFGFITEYYDESSEMDPSELFNENEKSLFSTVAERAGEIVERIKTSRTFFEVLESIGDGVVSTDMEGRIVFINNVAAKMIGKEESEAVGEQINKVLKLYDSETGRRILLDTKKMITAEGSISFHPNAAIVSPAGTMRLLADSAEFVQDDDGEVIGIVHSFKDVTEERGFLKRLADNESRFRLLFDNMGMGVMICSVEGHAEKFILRDVNKAAERLEGVRREKLIGRDIVEAFHGSERFGLVEVFRKVYSSGEPAHIPATHYSDKTGSGWKEVSVFKLPSGEIVSLYQDVTQRWRYQTELEMQSHILNEVGKAIVATDSNREITFWNKAAEELYGWKSEEVIGKKASEVLMPEGNEKKVNEIFSSLLEKGIWKGVFSQKKRNGEIFIAEMTDLVVPVEDGKSRIFVNVSSDITEQKRTEETLKNTLRSTVEVLSVITESRSPFSVGHQKNVSRLASEIARKLGLGEERLGFVTLAGLMLDVGMIAVPSEILSKTGLLNDIERRLIEQHVVKGKEILEKADFFRPIIDQIYQHHERLDGSGYPRGLKGDEIILEARILAVADVFESMVSHRPQRPALGIEKALLELKSNAGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M6</accession>
    <name>I2F7M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731684.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2301"/>
    <dbReference type="EnsemblBacteria" id="AFK07929">
        <property type="protein sequence ID" value="AFK07929"/>
        <property type="gene ID" value="Theba_2301"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2301"/>
    <dbReference type="eggNOG" id="COG1604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057129_1_0_0"/>
    <dbReference type="OrthoDB" id="1171756at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="355" mass="40505" checksum="33AF21714A58EE2B" modified="2012-07-11" version="1">MILDCNSNTLFEIKKDSIISELTDELQKNKPNENVLSKILRKLGDSELLITFKYLEAIGYSDGENCVKQVYVRRRKNADYGCSFAKETFNKIDATALDILPLYSFIIEFDFTLKKPYISKDDENFTIIENSIKRERILGCPYIPGSTWKGCLRSALWHEGMKEDDEQITRIFGNERQNKESFRQGRLHFFPSFFDKVDYEIVNPHDRKTRTGTVPILIESIPSGSNSKFSLLYVPFDLAGKEKEESAKQMLEDLKVIAKGIEAMFTVYGFGAKTSSGYGIAKINDGFISINAKDNKVKIEPELPKSFSLNEAKTNLRSTLKNHLNSSPERGFIEKRFDTLMSFKESVGKAIEVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N9</accession>
    <name>I2F7N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487518.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07942">
        <property type="protein sequence ID" value="AFK07942"/>
        <property type="gene ID" value="Theba_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2315"/>
    <dbReference type="HOGENOM" id="CLU_181401_5_0_0"/>
    <dbReference type="OrthoDB" id="2034992at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021321">
        <property type="entry name" value="DUF2922"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11148">
        <property type="entry name" value="DUF2922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="69" mass="7858" checksum="3C1C98891A001B7C" modified="2012-07-11" version="1">MRNLSVRWYDSTAKKSKGFYIKEPKETLTQAEVETVMGNLVTLKVIPSSYAVDYAAVIDTQKNELFNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P0</accession>
    <name>I2F7P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731697.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07943">
        <property type="protein sequence ID" value="AFK07943"/>
        <property type="gene ID" value="Theba_2316"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2316"/>
    <dbReference type="HOGENOM" id="CLU_2617910_0_0_0"/>
    <dbReference type="OrthoDB" id="1988233at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="78" mass="8393" checksum="ACC5404123C164EA" modified="2012-07-11" version="1">MGLGTTVMVVGTEKSLSITWDTGVIEDDKPVLSRQTLSVDSAMTAQEAYDAAYNIASLTNYIIADIRLIETQTLGPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R8</accession>
    <name>I2F7R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2346"/>
    <dbReference type="EnsemblBacteria" id="AFK07971">
        <property type="protein sequence ID" value="AFK07971"/>
        <property type="gene ID" value="Theba_2346"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2346"/>
    <dbReference type="eggNOG" id="ENOG5032VX1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582580_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="500" mass="55266" checksum="15654637BACDF51C" modified="2012-07-11" version="1">MNDLKLFFKHKLFLFPGKRGNRGGLSGQLFIFAVFAIMIGTFLWEVYGSTAGVSIEGVSLGKVMAGFFLTISGFFFLISFSATSSYLFMRNEEIDMLLVLPVKRVSIIAYQIMISTVYQGLTLSVFIGIALPFHLRVDPSPWIGIPALVLVVIDTVLLASIVSVAFGKFMSRAAARKVMFVVQIIAGFMFFIIVQLVPRSTDNIPLYLQKLASAWGVLSNPMNVFTWSVKASEQPIYLLVGLGAIPVLGYIFFRVASSIKFEPVSYTKSRTKTVSFNGRSRGVLLRRELKIYKRYEQLIYYLFYPVVFGLIFGLISDDAVASIFTTVLISTIFTTIQSAFLMGREFPFIETTKTLPISLGRMIALKATLPVLLGSVLFVGVLTTSILVKGESFGYFVVVPIVFVLYITSSLLGIRGVLVSPPDQMDNPNTFMRTKFVLLNQVICMGLSFGAIMPLTTILSGASESNSNIWLILISLASLAVAILISIFSYKKVKLVINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F817</accession>
    <name>I2F817_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731802.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2459"/>
    <dbReference type="EnsemblBacteria" id="AFK08070">
        <property type="protein sequence ID" value="AFK08070"/>
        <property type="gene ID" value="Theba_2459"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2459"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_2_2_0"/>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="123" mass="13643" checksum="021399C6FF0F387D" modified="2012-07-11" version="1">MKIAIPTIDNKGLQSHISEHFGHSPFFAFVTVENNEIVSHEIEVNPFEQHEPGEIPGYVKSKGADVIITRGMGGRARQFFETLGVHAITGASGTVEELVKTYIEGELSSLEYEPEDHGKFHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F859</accession>
    <name>I2F859_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2504"/>
    <dbReference type="EnsemblBacteria" id="AFK08112">
        <property type="protein sequence ID" value="AFK08112"/>
        <property type="gene ID" value="Theba_2504"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2504"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031786_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="471" mass="51220" checksum="AF1C221C5D40AEA8" modified="2012-07-11" version="1">MKIVPMKKLIEEYFEQNKELMIRDIMRLVRIKSDKEEAKEGKPYGDGPAEVLAVALEMASEMGFKTKNYDNYVGAIDFDDQKNKLDILAHLDVVPGGDGWSVTEPFNPVVKDGRLYGRGTIDDKGPAVAALYAMKAVKDLNIPLKASVRLILGTDEECGSSDIRYYYGIEEEAPMTFSPDASFPVVNIEKGGLQGKFESRFEESTETPRIVSFKAGIKSNVIPGEATAVVEGIDPEEIRDCCEAVDKISGISFNLSTEGDKTTIKAKGLQGHASTPDKGRNALTGLLEVISRLPASQSTGFERLRALNSVFPHGDWLGEAAGVAMSDELSGKLTISLNILEYDGSSLNGTFDCRAPLCATKENLLDVIKAKLAGYGIDLQNDDIKPPHHVPGDSEFVKTLLRCYESYTGEKGYCISMGGGTYVHRLKNGVAFGCTMPGSENNMHGPDEFAVIEDLLTSAKIFTQAIIELCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C0</accession>
    <name>I2F8C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731892.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2573"/>
    <dbReference type="EnsemblBacteria" id="AFK08173">
        <property type="protein sequence ID" value="AFK08173"/>
        <property type="gene ID" value="Theba_2573"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2573"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062001_0_0_0"/>
    <dbReference type="OrthoDB" id="1187944at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="319" mass="36107" checksum="8AFDBDDE7528A0D3" modified="2012-07-11" version="1">MSNPARAEIEDLQGMVDLASLVFKSEMGKIFPVLFSQENVENMTIVKEKGRPVSMIGLLPREISFFGHRMKVGLIGSVCTHPDYRGKNYGAVTLAKAEEHAIDIGLSLLIISGGRGLYQRFGAVRPPGTKRILVKPGRTASMREAKISDIGKILDLYRMKPLRYIRNFTDFEKTFSTGYAEARKTKTYLSEKAYITVVEREDNHYVIEYGGGSKDVISLTRGYIEKLGLKGCIIVAERHFKAEESLPFEFPGTAKIISKRSFFDQMEGYFTEIMPSEDYDRFIETVERLSLAEFNQEVFCCSKFKGLPLSLPNYGFDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C7</accession>
    <name>I2F8C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731898.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2580"/>
    <dbReference type="EnsemblBacteria" id="AFK08180">
        <property type="protein sequence ID" value="AFK08180"/>
        <property type="gene ID" value="Theba_2580"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2580"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_0"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="265" mass="28730" checksum="2ED06D1568562502" modified="2012-07-11" version="1">MKILVLLKQVPDSDEVKLNPETGTMIREGVGTVINPLDLHALETALRIKETGDHSVTVVSMGPPAAEEAVREAIAMGADRAVLLTDRKFAGADTWATSMALARFAEKEGPFDLILAGEKATDGETGQVGPETGAMLGIPVATYVSRIVELDESGITIEREVEEGKEIWKLPLPSLVSVTKDVNEPRLPTLNGKKLARNASVERIGNDFLELDPSEIGLKGSPTRVVRIGTPKLSRKVEMYEGSSIRDGIDEIKKRLAPYLEVNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8C9</accession>
    <name>I2F8C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489443.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2582"/>
    <dbReference type="EnsemblBacteria" id="AFK08182">
        <property type="protein sequence ID" value="AFK08182"/>
        <property type="gene ID" value="Theba_2582"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2582"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_0"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="322" mass="35092" checksum="263A84B1DE89EA78" modified="2012-07-11" version="1" precursor="true">MRKVLMLLVMASLLFGATLGFAVYEIAFIVKATDSDFWQYTIVGAENAEHDLQGLVNVTVYGPPSESDIDKQVAILEDVVNKKPDAIVISSTSSEAPSLILDEAYKQGIKIILIDNFVYDTGYNSFLATNNKVGGALAADKLVEYLKAAGKDLKGKIGLVSAMAGVQVLTDRDDGFKTRLAEIAPDLEVLPTIYVDNDISRAANATEDLLIAYDDLVGMFADNNHTGDGVARVIELQGLQDEVIAVAYDSDPQEIDALRNGSLKALIVQDPHGMGYKGVMFAFMAINGEPLPEYFDTGVYVVEKDILDDSMWVLDPFSRKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D4</accession>
    <name>I2F8D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbsK</name>
        <name evidence="8" type="ORF">Theba_2587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731903.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2587"/>
    <dbReference type="EnsemblBacteria" id="AFK08187">
        <property type="protein sequence ID" value="AFK08187"/>
        <property type="gene ID" value="Theba_2587"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2587"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_3_0"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="32961" checksum="A81517EA0DB119A2" modified="2012-07-11" version="1">MNKVTVFGSYVMDLTTLSPHIPVVGETVFSGPFKMGPGGKGFNQAVAARKAGSDVKFMTKIGKDLFAPFVKDAFDKFGITKDYLLESDTAGTGVALIIVDENNGNNAIAVAPEACNELTVEDVIRHRDIFTSSDVFLTQFEANLDATYEAIKLARDSGARVLLNPAPVKEFDHSILKYVDIIMPNEIEASLMTGIPLDGMESIEAIASELKKSVDTVLITLGGKGVYCPSVNGGLVPACKVKTIDTTGAGDAFAGVFAAYLSRGESLERAIDYARAGAAISTTRFGTSPSMPEREEIEALVNEITGGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F0</accession>
    <name>I2F8F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731913.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2603"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="EnsemblBacteria" id="AFK08203">
        <property type="protein sequence ID" value="AFK08203"/>
        <property type="gene ID" value="Theba_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2603"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_1_0"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="339" mass="37656" checksum="FF8A3E3B5BF8E426" modified="2012-07-11" version="1" precursor="true">MIWNRVDEIVSCGIEKAVYPGAVVLVGKDTEVLYKNTYGFIAVDDNTPTTFETVYDIASMSKVVATTSAIMILVSRGELSLWDTLGDFFDVPESKKGISIFHLLTHTSGMQPYSEAWRELKGRELLKSIIDLEPETVPMEKINYSCLNFITLMAIVEKVTSVKFDEFCSQQIFEPLGMNSTTYLPKSLDHVAPTSEREGKILRGLPDDELAYYLGGVSGNAGVFSSVEDLFKFVSSLMYARLVPSRVFETFISETVSIGESKRHLGWMAPARGSSAGDMLGEEAFGHTGFTGTSIWVDPLTGLFVIMLSNRTNISRRDTIPQIQQIRRRLHNLVFGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F4</accession>
    <name>I2F8F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731917.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2607"/>
    <dbReference type="EnsemblBacteria" id="AFK08207">
        <property type="protein sequence ID" value="AFK08207"/>
        <property type="gene ID" value="Theba_2607"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2607"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_2_0"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="241" mass="27957" checksum="B90CCF6BE7370E6A" modified="2012-07-11" version="1">MIEAGAPVYYRIYKELKRRIGKGVYSKRLPTEKELCNEFNVSRLTLRRALDELKRESVIESAKGRGTFIVDEKREESISSLTGFTEEAARDKQRARSVVLSDGLMVPSEEIAKLFGIPDDAMVVLLERVRYLNDEPYGIERAYLNPLADIRILNIVNRDMSEASLYNILKNELSLVLDHALENIEVCRLTKEEAKHLKVNENSYGIRRERQTFTDKNICVEVVRSVYRGDRYRLKVVRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G6</accession>
    <name>I2F8G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731927.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2619"/>
    <dbReference type="EnsemblBacteria" id="AFK08219">
        <property type="protein sequence ID" value="AFK08219"/>
        <property type="gene ID" value="Theba_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2619"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="275" mass="31249" checksum="B8E4738DCF0023C3" modified="2012-07-11" version="1" precursor="true">MRRRGFGINIVALLISLIFLFPLYWTFLTAFRTEAQILAWPPDFLPRNLTTSNFKEVLSHPHDTPVFRWFLNSVIAAVSYASLSVFVGILAAFALARLKFRFRDTYFKLMLVSMAVPGMIHFLPNYTTVEAFGWTDSLIAIIVPGLASTFGIFLLRQFFISIPREIEEASIIDGANIRQRILYIIAPLAKESIIILWVMNFMSNWNDYLWALVVLYSPEKRTMPVGISTLQGKYVTQYGPLMAGALFVAVPSILIFLLVQRYYIKGIDISGGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G7</accession>
    <name>I2F8G7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2620"/>
    <dbReference type="EnsemblBacteria" id="AFK08220">
        <property type="protein sequence ID" value="AFK08220"/>
        <property type="gene ID" value="Theba_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2620"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566055_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="entry name" value="PTHR31451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="481" mass="55261" checksum="98AF7B8435057DC6" modified="2012-07-11" version="1" precursor="true">MKRLFVIILFLAVAFSGIASFVKISPAGKYFEHNGRAIVPVGFNDAITWPSLISLSYGNKEAAEEYFEKLSHYGVNTLRIMFEYAQDRSGLSLFESPLGTYNDTVIGIWDNIISLAEKYNIYLIITPWDPFWMYENWDVNPYNADNGGPISTMAEFLTDEEALEWQKARFKFMIERYGASEQILAWELNNEIELWYGHIFYKADYSVGNEARKWIEEISTFIRALERDLYGETHLLTVSTAKPALTGILSGKLYRFDHIDFFTTHFYFDTIKDPKDPIKIAEDVVMNINYHNYLFNDSIPFMDSESGPIDRWPQPSRFDTACYKAFSWAHLASGGTGIGMRWPYTSPHLMPDYLLQVLKPISQFIESEGIDWLDFSGINLDNEIIISSDKDIFHTCSGNSFENLTSVIGWVASKETIGNVVIKSSALDEGTYLLEIWSDSYERDVDSYILGSFKFDSKDDFSLQLSIDQSSFAYKIYRIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P3</accession>
    <name>I2F8P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731990.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2697"/>
    <dbReference type="EnsemblBacteria" id="AFK08296">
        <property type="protein sequence ID" value="AFK08296"/>
        <property type="gene ID" value="Theba_2697"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2697"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_3_0"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="768" mass="83955" checksum="76D26CEBA103092A" modified="2012-07-11" version="1">MPERHEKVVGKKINRVDAREKVSGRAKFAADVSFDRQVNCALVIAKKAHGVLKSIDASSAKKIPGVEGVFTWRDVPGENQLGDVIKDMPCLVKEGERVRFYGDVVAVVAASSKKIAEEAADLVNVEIEELKPVLTIEEAIKDEIVIHGKSNVGVSRRIRKGNASKYFENSEHIFEGDFYAHYQEQAYMETQGVIVVPDIDYGFTVYGTMQCPYYVQGAVSNVLGIPMSRVRVIQTETGGAFGGKEDIPSYVASYAAIVANNLRRPAKLIYSREIDIQTTSKRHPIKSHYKVALEGKKIKAMTIEAYMDMGAYATLTPIVIFRTLVHAAGAYEIENVDVDVYAVYTNKVPPGAFRGFGSPQVLFAVESMLDDIAVQMGFDPMEFREINTLRPGSRTSTDHLLVNSVGAPETLSRVKKASKWKELVKETEEFNKSSEEVKRGVGLSHIFYGVSLGAGGQALDKSGAHVLIDRDGSVEVRIGGTEMGQGAKTVISIIAAEELGQSMDKIVVHQPDTAFVPDSGPTVASRTTIYSGNAVKSACASLRERLASVFCELTGCRLSSVRFEDGCVYGENENKLSFDEVVEHAYKKNVKLFETGWYETPKLKFDMDNGIGEAYVTYSYASQVVQVEVDLATGYSKVIKAFTAHDVGRSVNPEGVVGQIQGGFAQGMGYAIFEDMKQKDGKIISDNFNTYIIPTVHELPKELVIDVVEDPFPEGPYGAKGIGEPSLMPVPGAVANAISMAIGKRVRRIPVTPEYVLQLLENGSSLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P8</accession>
    <name>I2F8P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoglycerol transferase family protein, alkaline phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731994.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2702"/>
    <dbReference type="EnsemblBacteria" id="AFK08301">
        <property type="protein sequence ID" value="AFK08301"/>
        <property type="gene ID" value="Theba_2702"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2702"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021310_0_0_0"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="7">
        <location>
            <begin position="223"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="612" mass="69513" checksum="00BB54826D951DFE" modified="2012-07-11" version="1" precursor="true">MKKTYQWTTKSITIIVVLILLKSLVFYGYTAELARLSVLLGTIAWMAFLLLLFWNVFNGKFFLLYCIISCILFVDFLYFQYFGFLPSVKELVHVGHVGAISESIVYVLHPISFVFIIDLIPVGLYLRKKQSRQDETPIRKPTYPDRIIAFVLLISLLIPFSSESLQSYFVFNRYGVFAYHMFDLVRVIPGVDGGITVDETVSYNGYVNKMAERGKYFSVAKDRNIIVIQLESFQDFLVNFVYNDQEITPNLNRLVSSDSIYFDEIYQQVGAGNTSDCEFVILNSMHALGDVSVYQTREENSFYALPSLLKSKGYFPVAFHGNNGWFWNREKIYPSLGFDDFISLEDMENDEIIGFGLSDSSLFKQTLGYLRGIEEPFFAFIVTLTSHNPYEIPEELRAIELLPEHEGTLFGNYIQSVHYTDAALGEFIEGLKEAGLYDSSLIALYGDHAGLYPFNKENKDILSELLACEYDFVHAMNIPLLFHIPNSNLNVLNSKPGGQIDFFPTLLNLIGIVEKSGILFGRDLLNSSSGFAAFTHYVPEGSFIDNNRIFIMSSDGILDNSEAIERRTGKMITPYSCLDGYKDSIQQIQASKYLILNNSISNLMGVSNERDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E0HVU2</accession>
    <name>E0HVU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0851</name>
        <name evidence="2" type="ORF">Theba_2023</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">MesG1.Ag.4.2</strain>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0851"/>
    <dbReference type="EnsemblBacteria" id="AFK06564">
        <property type="protein sequence ID" value="AFK06564"/>
        <property type="gene ID" value="Theba_0851"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07666">
        <property type="protein sequence ID" value="AFK07666"/>
        <property type="gene ID" value="Theba_2023"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0851"/>
    <dbReference type="KEGG" id="mpg:Theba_2023"/>
    <dbReference type="HOGENOM" id="CLU_3390221_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="32" mass="3938" checksum="EED66D4A8ACCE640" modified="2010-11-02" version="1">MRKRRENLADVDRYIDKIKTDALKRYMSSIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J1</accession>
    <name>I2F1J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">Theba_0041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729969.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0041"/>
    <dbReference type="EnsemblBacteria" id="AFK05794">
        <property type="protein sequence ID" value="AFK05794"/>
        <property type="gene ID" value="Theba_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0041"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_0"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="263"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="353" mass="38260" checksum="5E1AF62C9C43F560" modified="2012-07-11" version="1">MSRVVLKAGSNLLVKSNGEIDKKYVTELAREISLLKSSGSQVVLVSSGARAAGFGYLEGKKSNGDLYMKQALCAAGQVQLMKLYETVFDLFGERIAQILVNRDDFGDRKRFLNLRNTLIGLLELGLVPIVNENDTTSTEEIMFGDNDILASMFAIGWQANLLILMSTIDGIVDEEGKVIREFDPSKRLKNIENNSWGTGGIDTKIRAARAASASGIRSCICNGRDFRKIEEFVQGKDVGTIFSPIESPGARKTWIGFLSTPRGKITVNRGAEGAIARGKSLLAVGVEDVSGEFSEGDVVSICSVKGKEVARGISNFSASEVQKIKGVRSDRISSVLGHDCAKVVVHIDNSYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J2</accession>
    <name>I2F1J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729970.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0042"/>
    <dbReference type="EnsemblBacteria" id="AFK05795">
        <property type="protein sequence ID" value="AFK05795"/>
        <property type="gene ID" value="Theba_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0042"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_0"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="214"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="446" mass="50128" checksum="23D37D53399E9FDD" modified="2012-07-11" version="1">MYSFPDLLYSDVRIEDVSKSDIVVTLGRTDNMKEQRYSAAFIRVFDGERWYFSATTDLDSVQDELDRLASLAKKNRSIEEHGVVRKLQANKGSYLRFDGDLNVFKASLNEKYDILSSYFPHVEKSELVKFWRGQYIDQRVGKRFFSSKGANLEFDYQRVGFRLLFQMAKDEEQFMERYDLAGNELDSIKGLHEEVRKTVETSEDFIRNARPVVSGSYPVILSPEAAGVFAHESFGHKSEADFMIGDRTMMEEWKMGRRVGSEILSIVDDGNKPGVGNVIFDDEGTKAEETYLVREGLLSGRLHSAETAAALGEELTGNARAVNFEYEPIVRMTTTFISPGELSFDELLSGIKEGVYVDSLNHGSGMSTFTLAPCRAYMVRNGKIAEPVKISVVTGSVFQTLNEIEGLTEEFKLLSFALGGCGKMEQYPLPVGFGGPYVRVRSLSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1M2</accession>
    <name>I2F1M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729998.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05825">
        <property type="protein sequence ID" value="AFK05825"/>
        <property type="gene ID" value="Theba_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0074"/>
    <dbReference type="eggNOG" id="COG2832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113299_2_0_0"/>
    <dbReference type="OrthoDB" id="2047758at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007401">
        <property type="entry name" value="DUF454"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35813">
        <property type="entry name" value="PTHR35813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04304">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="146" mass="16571" checksum="A5B2FC23CD16A50A" modified="2012-07-11" version="1" precursor="true">MRLKRILLSIAGSLFLFLGITGIILPLLPTTPFLLLAAFCYLRSSKKLYRWLISHRLFGAYIYSYLHFRAVRRRARNLALLLLWSTLTLTMILISNTAVTLILVGVGVAVSIHLLQLKILTAEMLEKVREGLKNPEMIDKYPGSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1N5</accession>
    <name>I2F1N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490156.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0088"/>
    <dbReference type="EnsemblBacteria" id="AFK05838">
        <property type="protein sequence ID" value="AFK05838"/>
        <property type="gene ID" value="Theba_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0088"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="25773" checksum="28A54B19116C5E19" modified="2012-07-11" version="1" precursor="true">MKILIVEDERSLGRLLKESLEREGFVAELAVDGEEGLYMALNGPFDVIVLDILLPKLTGWQVLEKIRDSGSRIPVLMLTALDSIEDKVRGFDLGADDYLPKPFDIRELVVRIQSLLRRAQFGGAPSRVLRVGDLELDMSLKTASRGNEKIELRKKEYQILEYLMLNSGRVVPKSELEEHLWNEDDELWSDVIRSHIKNIRKKVDGGRRKKLIKTVRGMGYEISDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P3</accession>
    <name>I2F1P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation/cationic drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730016.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0097"/>
    <dbReference type="EnsemblBacteria" id="AFK05846">
        <property type="protein sequence ID" value="AFK05846"/>
        <property type="gene ID" value="Theba_0097"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0097"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080675_0_0_0"/>
    <dbReference type="OrthoDB" id="1204218at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="297" mass="32533" checksum="635B6947119D1A66" modified="2012-07-11" version="1" precursor="true">MFYLLLAILSSSSIAMIFKVTEGRSYNRLAVTTFNYLSAFLVALVMMAVERPAIGPGGGSPAEVIVKGERLFSLTSSVVWGLSLGLVSGLFFFLSFIFYQKSVRESGASLSGAFGKLGILIPMILSLLVWKEYPEALQWVGIFLAIFSIVLVNNPFGSGRQNFRAALVMLFITGGLAEFMNKLFQNYTVSGYKNVFLFSVFASAFAISAFFLKRSGKSFRKREAIIGLIVGLPNLFSSFFLIMALEEMKGSVVFPVYSAGSVVMISLGSLMFFGEKLKKLEMISLGMVLISLIIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1P8</accession>
    <name>I2F1P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized Fe-S center protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730020.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0102"/>
    <dbReference type="EnsemblBacteria" id="AFK05851">
        <property type="protein sequence ID" value="AFK05851"/>
        <property type="gene ID" value="Theba_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0102"/>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046240_0_0_0"/>
    <dbReference type="OrthoDB" id="1000643at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="356" mass="38425" checksum="9288214508808599" modified="2012-07-11" version="1">MSKVFFTNMETTPEMGLLKKVEALLKRAGLEDVVQKDKLVAIKLHFGEYGNLAYIRPNYLRVIADQIKKLGAVPFLTDANTLYKGSRSNAVDHITTASLNGFTMESVGVPVVIADGLRGSDEIDVEIEGDYIKKAKIASAIALADSLVVVSHFKGHEQTGFGGALKNIGMGSASRAGKMEQHSESKPVVREKNCVACGMCEKNCPTGAITVDRVARIDYEVCIGCGQCIAMCNYGAMSAGAGGTPESLSKKIAEYALAASKGKNALYISFINNVSPDCDCWHINRPPVVEDIGIVVGRDPVAVDKACIDLVIGRLGYDPFERAHPGISWRHQLEHAEKIGLGERSYKLEKVACFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V0</accession>
    <name>I2F1V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730067.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0162"/>
    <dbReference type="EnsemblBacteria" id="AFK05903">
        <property type="protein sequence ID" value="AFK05903"/>
        <property type="gene ID" value="Theba_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0162"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_4_0_0"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="474" mass="53461" checksum="6318AAE29E5F96EA" modified="2012-07-11" version="1">MSGIVVTLKPERKMIEGSLSYLRHRGSKTRVLKTQGEASMGAVVSNAFDENMIVFEGTRESVVFDGILRNFPGEVWPRRILELYKENRSGFLNELDGSFAFAIDTDDETFVARDPLGLKPLYYGRCNGGIAFASELKALTPFCSHVQVFPPGHFFSSNEGFSEYSSLEDLLTERQVKSEEEAAKRLRTSLERAVDNRMTAVKSEPIVFLSGGLDSSCIAAVASKLNGSLKTFTVGSEEGKDPAFAKEVSRYLGTDHREYTYDFKEMLEVLPDVIYHLESFDPPLVRSAIPNYIVSKMAAEEDSSFVLMGEGADELFAGYEYMKELPSAESVDEESLRITKNGYLSGFQRNDRMALAFGIEFDVPFMDPNVVDLAFSIPVDWKIHGPEKTEKWILRKAFENDLPESVVWRKKSKFSVGSGSSHIMKEYAEEAISDSEFERERQNNGIRSKEELLYYRIFDEQFPCRGAADTVYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X1</accession>
    <name>I2F1X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730088.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0184"/>
    <dbReference type="EnsemblBacteria" id="AFK05924">
        <property type="protein sequence ID" value="AFK05924"/>
        <property type="gene ID" value="Theba_0184"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0184"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="290" mass="33194" checksum="29B40058DFC25B20" modified="2012-07-11" version="1">MERDQLTLRIRNLQKTYSGNVKAVRGIDVDVENQRIYALLGPNGAGKTTVLKSILGLVKYSGSVEVFGRPIEEVRERISFVPEEKNLYENLDIESTLRLSSRISPRFNEKQARELIENYKLPYRKKIRTFSNGMRTALYLAVALSTDADLYILDEPTWGLDPIMRDDTLELIREKVILGKTVIYTSHVIPEVEKIADEFSIMVSGKIKYTGNLDGIKEKYRIIKMPLKDKTKPSSERCLAVAKEINRLSMIVEYSEATEEYYKNDEAAISIPDLEEFFQILVRSENGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X6</accession>
    <name>I2F1X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730093.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0189"/>
    <dbReference type="EnsemblBacteria" id="AFK05929">
        <property type="protein sequence ID" value="AFK05929"/>
        <property type="gene ID" value="Theba_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0189"/>
    <dbReference type="eggNOG" id="COG5421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022426_5_1_0"/>
    <dbReference type="OrthoDB" id="995276at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="523" mass="61087" checksum="FBBA679FEC8B86CB" modified="2012-07-11" version="1">MFLRLKHFKNKDGSTRSYLQLVENIRVGNKTRQKVLVNLGRVDDLQNSGQIDRLIESLRNFSTKEWIRKEALNVNQTYLWGPVVIFEQLWKELGIERVLRRLLGDTDAVSDYVEAIFAMVLNRLVEPRSKRGVDKWVAKVYRPEFEQLSLQHYYRGLDYLEKFKEEVEEELFSNVKTLFNLNLDLVFWDTTSTYFQGEGPELSMYGRSKDHRSDCKQVMIGVLMTKDGFPVAHQVFPGNTADIDTFKIALEDIRRRFNIDRVIVVADRGMISNGLIEEIDKAGLSYIFGVKMRRSKRVEAVLNQPGDYEEVEENLKVKEVLHEGERYVICFNPFQAERDRIKREEIVKNLTKKLKQGPKSLVGNRGYRRYLSMQKTDVKIDQEKMASEIKYDGKYVLRTNAKLTNREVAQSYKLLWKVERAFRELKSGLDLRPIYHYTDTRVKGHIMICFLALVMETALCRKLKEIGSTFSYAEILEDLTEIRAVEITVENKHFLARTETMGNAYDAFKALKIRPPDLLKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F225</accession>
    <name>I2F225_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0244"/>
    <dbReference type="EnsemblBacteria" id="AFK05978">
        <property type="protein sequence ID" value="AFK05978"/>
        <property type="gene ID" value="Theba_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0244"/>
    <dbReference type="eggNOG" id="COG3879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942710_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="295" mass="32896" checksum="54B6001452603F83" modified="2012-07-11" version="1" precursor="true">MKGLWFFLIVLIIVVALGSFFNIYFLKQFGDEMISSLSTREIESKLQLMSERVSLLNTNLDSLSSVEVREDLSRIITDFERIIADINYVSNSLSSNPVLDSIAQLSSDLKLIKRSIDSLDSGESVDYSTQIEGVRGKIVSLEWQVEELKKLLESSTADLKKSVMNVNAFSSQADQSYKEEVGKGVRIRIESGFKGSSILHDSDILMILNELYALRATEISLNGKRIMPYTYVRCVGATVIINDEPTQISPIVIEVLGEYDYLVSGLGLMKEFFAGREIDMTFLPLEFITIPAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F229</accession>
    <name>I2F229_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Serine acetyltransferase</fullName>
            <ecNumber evidence="4 8">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Theba_0248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730142.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0248"/>
    <dbReference type="EnsemblBacteria" id="AFK05982">
        <property type="protein sequence ID" value="AFK05982"/>
        <property type="gene ID" value="Theba_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0248"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_1_0"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SATase_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK05982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="191" mass="20654" checksum="C04C16C3F6897F97" modified="2012-07-11" version="1">MKAFENIRQTGIDISDDLKAYLEKDPTVSRKWHVFLFSAGFHGLLLYRISNLLWNGGLGLFARILHYFSRVAYSMDIHPAARIEGGVVIDHGSGVVIGSTASVGKGTLIYHGVTLGSKNVMTGKRHPDVGRNVVLGAGAKILGPIYVCDNARVGANSVVLEHVPHGSLAAGIPARIHVPTVERRRNQDEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F254</accession>
    <name>I2F254_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">Theba_0275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730163.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0275"/>
    <dbReference type="EnsemblBacteria" id="AFK06007">
        <property type="protein sequence ID" value="AFK06007"/>
        <property type="gene ID" value="Theba_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0275"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_0"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="119" mass="13591" checksum="4959B339ABA44364" modified="2012-07-11" version="1">MRVKGGVNTKKKKLRYLKAAKGYRGALSRRYRLAKQYYIRSGVYAYAGRKVRKRDFRKLWITRINAGARIAGTKYNDLIHGLKIAGVNINRKMLADLAVNDFGTFKEYCEIAKSALNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F259</accession>
    <name>I2F259_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">Theba_0280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0280"/>
    <dbReference type="EnsemblBacteria" id="AFK06012">
        <property type="protein sequence ID" value="AFK06012"/>
        <property type="gene ID" value="Theba_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0280"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_0"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="132"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="210" mass="23447" checksum="25D627EFDD6BC29E" modified="2012-07-11" version="1">MFDQLTVVNHPLIQHKLGIMRDDQTGPKEFRELLKEITLLLTYEATRHIPTYDKEIKTPLVKMVGQCIEDKKVTVVPILRAGLGMVEGVLSLMPNASVGYIGIYRDPDTIQPVEYYSKLPSVDENTQLFVLDPMLATGVSSSWALKVVKKAGAKQISLMCLIAAPEGVRFIEKNHPDVKIFTAALDERLNDHAYIIPGLGDAGDRLYRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F271</accession>
    <name>I2F271_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">Theba_0293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730175.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0293"/>
    <dbReference type="EnsemblBacteria" id="AFK06024">
        <property type="protein sequence ID" value="AFK06024"/>
        <property type="gene ID" value="Theba_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0293"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_0_1_0"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="25001" checksum="BBE19B9C836C0C64" modified="2012-07-11" version="1">MVFSSEFLEPSFFAKYEKLIELMLSSPHNLSSIKEFERAMTVHIEDTIIPFEGSSLSGRCIDIGSGGGIPGLVLAISFPKSNWTLLESIAKKTREIERFARDLDLTNVAVKTARAEEFAKEAGETFDSAFLRAVGRCDISLELAAPLVKVGGYIYLYKGPGWLDEKVFSDAAERVLGLRLSCEKEYRLSDGSKRFMVVYEKERATPSEFPRRSGVASKLPLGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F272</accession>
    <name>I2F272_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ORF">Theba_0294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0294"/>
    <dbReference type="EnsemblBacteria" id="AFK06025">
        <property type="protein sequence ID" value="AFK06025"/>
        <property type="gene ID" value="Theba_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0294"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="234" mass="26176" checksum="B4F7EFEC9A077FC2" modified="2012-07-11" version="1" precursor="true">MTEKKGKLWIVGTPIGNLDDMTIRGKRVFEEADLILAEDTRRMRSLLSSLGIENKDVVSLNMHNQEERLSFIIRKLDEGAEIALSSDAGMPVISDPGAKIIRVCRDRGFEVDVSPGPSAVTSAIAISGFPGSHFTFLGFLPRGKNRRRLLRKISRGSYGESLIVFFESPFRLMETLREILEIIGDREIFIGRELTKLFQESFFGCVSDAIQKFAFSEVKGEITVVLSGRDEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2A1</accession>
    <name>I2F2A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730196.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0325"/>
    <dbReference type="EnsemblBacteria" id="AFK06054">
        <property type="protein sequence ID" value="AFK06054"/>
        <property type="gene ID" value="Theba_0325"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0325"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="390" mass="44616" checksum="7A8BA8397A76D798" modified="2012-07-11" version="1" precursor="true">MKLLEVRNLKKYFPIKQGFLVERVVGFVKAVDDVSFSVDRGKTIGIVGESGCGKTTIGKSIVRLLEVTDGEMLIDEEDTTFYFMKKRRAKQYLKAKYFDTSRFNNGDNSEFEPYEKKMYDVYNRANRDASKAIDYLFEKADQKKRLLRRKAQIVFQDPMSSLNPRMTVGQMLTEPLLFHELVKNLDEAIEKVKELLVQVGLKPYHVDRYPHQFSGGQRQRIAVARAISVNPDLIVLDEPTSALDVSVQAQIVNLFQKLQEQLNAGYVFISHNLSLVRFISQEVSVMYLGRIVEQGNSESIFKNPLHPYTKALLAAAPIPDPKKKRNRKDLVGGQVPSPINRPTGCFFNPRCKYRMDICTKEYPPMVRVDENHFVACHLYSTSQEQGGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B6</accession>
    <name>I2F2B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730208.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0340"/>
    <dbReference type="EnsemblBacteria" id="AFK06069">
        <property type="protein sequence ID" value="AFK06069"/>
        <property type="gene ID" value="Theba_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0340"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_0"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="365" mass="40048" checksum="768235C4E16D9D31" modified="2012-07-11" version="1" precursor="true">MWKYFLPTRVFAGRQVIGQNGELLKEFGTKAFIVTGKSSAKKSGALDEVLRMLEALDIPSSIFDEVEENPSFFTVEKGGRLLSENECDFVIAIGGGSPLDAGKAISAVGMNGCSCEDLYRGKNLPSHPIVAIPTTSGTGSEVTQYSVLTNADGQKKGFGMPSIFPAISFLDPRYTVTMPLDVTIATALDALSHSLEGEVVNKGQNPLLKTLSREANRLIKDSLDRILLDEDDIDLRERMQFAATLAGIVIAHTGTTAVHAAGYPLSSFKNVKHGMANALILVEIFKKIAEADKDRISAAIDPFESLDELQIFIQRFISGRISLRISDEEINEWSDYTSKASHLKKTPGNFDKEFFMDLYRRINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C6</accession>
    <name>I2F2C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ORF">Theba_0350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730214.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0350"/>
    <dbReference type="EnsemblBacteria" id="AFK06079">
        <property type="protein sequence ID" value="AFK06079"/>
        <property type="gene ID" value="Theba_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0350"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_0"/>
    <dbReference type="OrthoDB" id="916845at2"/>
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        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="266" mass="29501" checksum="F7A347B42ABD8635" modified="2012-07-11" version="1">MNVREIVQMKGQSKLSVISAYSYFEAKFAEEAGLDMIIVGDSLGTLVMGKRDTLSVTMDEMIWSLKSVRRGAENSFIVADMPFGSYQCSREKAVENVVSFLRHGASAVKIEGGFETANLIKHLVDSGFPVMGHIGITPHHASLVGEYPVQGRDEKSIKRLIESVNELEEAGVFAILLEMVVEDVAKRLTEDSSVPTIGLGSGRYCDGQFLRWHDLLGINDESSPRYIKRFADLKSNIISALRRFDEEVKSGVFPEEKNAFEGTEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2D3</accession>
    <name>I2F2D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0357"/>
    <dbReference type="EnsemblBacteria" id="AFK06086">
        <property type="protein sequence ID" value="AFK06086"/>
        <property type="gene ID" value="Theba_0357"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="178" mass="19924" checksum="B689D83E097F1E00" modified="2012-07-11" version="1">MERSVGEERIFSGRILGLERHTVILQDGSLALREVVRHPGAVAIVAFVSEQLLLVRQFRFPVQKYMLEIPAGKLDAGERPEDCARRELLEETGYVPRFLHKLITIETSPGFSDEIIHIYVGEVEKSQEPCPDEGEFVEPVLVDSKEVVKMIIGGQITDSKTVSGILLAFAGRESDKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F7</accession>
    <name>I2F2F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative periplasmic protein (DUF2233)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730233.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0382"/>
    <dbReference type="EnsemblBacteria" id="AFK06110">
        <property type="protein sequence ID" value="AFK06110"/>
        <property type="gene ID" value="Theba_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0382"/>
    <dbReference type="eggNOG" id="COG4632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035800_0_0_0"/>
    <dbReference type="OrthoDB" id="1587976at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="1">
        <location>
            <begin position="389"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="557" mass="61489" checksum="7204A6567AD2BF48" modified="2012-07-11" version="1" precursor="true">MKRIIFICFLLISLVSSAKNLIYLDERGQTRVFTNSVVTDRSMDFVKLDIIGELIRGVVVSQSLRQEETIMILPSGIIVSLSHETKRATVEFGSEFDNSMIFKDGMVYINAELLAAITDKSFFSETEALILYAQPVTIKSIVNRPESVSITLDRDVLPDFFTVWWTGSGSLALTLKPAKIDPFLDAEGVTVATGRGFVKISVEKPWPDVEYEIKGRTLTLMGKSGIGRTIEQETSTDFSLNIFESYSGGQKFTMSYLEMNGSSFSFGVQLANNGIGGLEKATDILRESGSEIMINGGYFDQNQNLPIGLLVQNGKVLGLPSLGRPAIYFTEDGKTYVTRMDILYLAKFDDRFVQITGVNSPYRGEAVLYTDEYRNSIPEFDDFTYLSVKDGRIVKEGFSSKVERDTDLLVLSPSSLQKIGDTAFVGRSVSFELMNSFGVKITGAVEGGPMIIHNGRPVTNYEQNYYSASLLDVRAPRTLVGIKETGEVVFIVIDGYQHSSYGLTFKEMIEFFKDKGFESLMCLDGGKSSVMSVNGEIINSPSSGVPSLPVIITGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H8</accession>
    <name>I2F2H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amino acid racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730249.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0403"/>
    <dbReference type="EnsemblBacteria" id="AFK06131">
        <property type="protein sequence ID" value="AFK06131"/>
        <property type="gene ID" value="Theba_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0403"/>
    <dbReference type="eggNOG" id="COG3457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067103_0_0_0"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="353" mass="38394" checksum="85021DCE6E2F1A93" modified="2012-07-11" version="1">MAKVVVNTVSIGANAKRVRELAEVNGVEIAAVTKVVCGDPTIASILLNSGVKEIGESRLENISRITNAGIDSDFLLLRLPERSKFREVLDNVDTVLIGDLDSLSKLYELSSETGQEVNFIYMIDTGDLREGVMYYEAESVLEKAFEIAGENLEGIGTNLGCFGGVIATPKKFEILLSLGEFLRKKTGYSLRRYSAGNTASLPLLEKGIVPKGINHFRLGESILCGTDVTNNREVPGTLQDTFTLYGEVIEIAEKPSVPIGEIGRDAFGRIPHFEDKGKRIKAILDLGEQDVLPSGLTPLVGGCEVLHASSDHLIVDVTESEKSFSVGDSIGFRMSYGALLRVMTSPYIRKVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I5</accession>
    <name>I2F2I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730254.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0410"/>
    <dbReference type="EnsemblBacteria" id="AFK06138">
        <property type="protein sequence ID" value="AFK06138"/>
        <property type="gene ID" value="Theba_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0410"/>
    <dbReference type="HOGENOM" id="CLU_859997_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043754">
        <property type="entry name" value="DUF5700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18958">
        <property type="entry name" value="DUF5700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="37032" checksum="C39C610153CF0D09" modified="2012-07-11" version="1">MSWLNTEEIFALIDLIDSSNDSYEERFKRVLATPLASMFKQFHIRDSEARECLVAAFSRREDLSGLSKDCTELMAYMDKIRERKLELRAFFDLIIENEAGIRSKAISKAQEYLPKGVTFDGLKVFFIPMPYNANADHRGVYFDPLFALDMGLEAIEEVMAHEAHHVARNSITKERLEFGDSPLDQLVYRFVGIECEGIANMVSDASRIPSMKRIALQRTKMMGEFEKHLELLQEVFLNLSFKNISDDEARSIMERSWFSVGSLAPVGMRMALEIENELGKDRLIETVGDTVGFLKSYQEVALKKSYYLLEDETFIKLGQLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2I6</accession>
    <name>I2F2I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730255.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0411"/>
    <dbReference type="EnsemblBacteria" id="AFK06139">
        <property type="protein sequence ID" value="AFK06139"/>
        <property type="gene ID" value="Theba_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0411"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_0_0_0"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="252"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="395" mass="44073" checksum="4063FA385BFF819B" modified="2012-07-11" version="1">MGRKITDSVTWVGKVDWELKKFHGEDYSTHRGSSYNAYLIRDEKTALIDTVWAPFAEEFVENLKKEIDLSEIDYVIANHGEIDHSGGLVALMKEIPGTPIYCTANAVKSLKGQFHKDWNFVTVRTGDTLNLGSKALTFIEAPMLHWPDSMFSYLDGDAILFSNDAFGQHYATELLYNDLVDQAELFQEAVKYYANILTPFSRLVIKKIKEVLSFNLPLNMICPSHGVIWREDPAQIVKKYLEWADNYQEDQVTIVYDTMWEGTRKMAEAIAEGIASASGSTAVKLFNAGKIDKNDIVTELFKAKAALFGSPTVNKGILAPLSGMLHEVKGLSFKSKKAAVFGTYGWSGESVDVLTKMVEDAGFEIVQPGLKKLWSPDEDSLDDCREFGSGFAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K5</accession>
    <name>I2F2K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730273.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0430"/>
    <dbReference type="EnsemblBacteria" id="AFK06158">
        <property type="protein sequence ID" value="AFK06158"/>
        <property type="gene ID" value="Theba_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0430"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997250_0_0_0"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="280" mass="32704" checksum="847C207BEC2F0987" modified="2012-07-11" version="1">MNNNSFQRIQELSRVDVVNILNLVFSDYVLRMHWTLESFERDVRENNISLSESFVMNVEGIHTGIVLLSFREKRARIDLMGVIPGFRREGVGFKMVDEAIRIAKWKGCDRIVLEVPEKDKRAIAFYEKFGFRHRRELITFFIRRPGIGDFSTKESDSGKVVECALYVMDKYKRNPEWEREPASFHHLERYNFDTVIDEQGREIAYCVWQERDSVFYVKDCGPTRAASFKEAIGAICSIAKSKNLTPLFPTVPDNDPLFAEAQEFEPEILLKQSEMIFKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L7</accession>
    <name>I2F2L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydrogenase, Fe-only</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730285.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0443"/>
    <dbReference type="EnsemblBacteria" id="AFK06170">
        <property type="protein sequence ID" value="AFK06170"/>
        <property type="gene ID" value="Theba_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0443"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_2_1_0"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="586" mass="64593" checksum="07B2CAA1D95C95D1" modified="2012-07-11" version="1">MPVTITVNGKDFTVDENQSILEACREVGITIPTLCYHPALSVVGSCRVCVVEVEGARNLSPACATQVADGMRIKTNSERVTRAIRFNLGLLLSNHPNDCMTCDVNGRCEFQDLIYQYDVEDMFPKTLRNVPYDTSSPSLFRDMNKCIDCGRCVRACDELQGLSILSSVNRGYHVLPLPALGAPIAATDCINCGQCSAVCPVGAITERMEFREVVAELRKHDKVLIAQTAPSVRVALSEEFGELPGTVSTGKMVAALRKLGFDYVFDTNFTADLTIMEEGSELLERVKEGGKFPMFTSCCPGWVNMMEKLYPEFTENLSTAKSPQEMMSALVKTYFAEKIGKRPEDIYLVSIMPCTAKKDEKGRDTLTVRGTRSTDAVLVTRELGKLIKMHKIPFESLEEEEFDSPLGISTGAAVIFGATGGVMEAALRTAYELHTGEELPRLDFDFARGFDGVKEAEIDMKGTKVRVAVVHGGSNVVKLMDKIRSGEAFYHFVEVMACPGGCIGGGGQPKSSQPGYLQKRMEAIYNIDKSSVIRKSHENPAIAKLYEEYLGKPLGHLSHELLHTHYKDNKKSVIERKKELEEIAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N7</accession>
    <name>I2F2N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730304.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0464"/>
    <dbReference type="EnsemblBacteria" id="AFK06190">
        <property type="protein sequence ID" value="AFK06190"/>
        <property type="gene ID" value="Theba_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0464"/>
    <dbReference type="eggNOG" id="COG3411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126515_4_0_0"/>
    <dbReference type="OrthoDB" id="1412344at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="125" mass="13298" checksum="1A378A2A04157B83" modified="2012-07-11" version="1" precursor="true">MAKIKSLEELMKIKENAMKGLKMRNSGKRGKVIVAMGTCGIAAGAKDTLRAIVDSLEEKGIDDVSVVQSGCFGLCDAEPTIEVHLEGSDPIIYGHVTPAQAKRVVEQHIVGGKVVGDLIVKRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2W8</accession>
    <name>I2F2W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492178.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0548"/>
    <dbReference type="EnsemblBacteria" id="AFK06271">
        <property type="protein sequence ID" value="AFK06271"/>
        <property type="gene ID" value="Theba_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0548"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="298" mass="33757" checksum="76AC51581E5B5868" modified="2012-07-11" version="1">MSDLIAISVDSGCAPSRDFVREHKLFFMGMKVIIDDKEYTDDFDFMENVFYRIVENSKEFHTAQPPLGQVLEYYNDIRSRGYTELLDIHFSSKMSGVYETCVMASKMVEGIDVRVVDTRKVSIGANLVARKLIKLVETGCSLDEVFESVPRVIDNTFMEFSVPTLKYLIKNGRIGKAQGLAGTLLNIKPILSVDEEGFISPIAKLRGMKKLQEQMVQNIVEFLQNRRKSITLYSIYGSEEYLTVMHETTEWLIESIESRLGISRSDIELVSGRIWPTIACHSGPAVFGLACYGEREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y9</accession>
    <name>I2F2Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ORF">Theba_0573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492205.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0573"/>
    <dbReference type="EnsemblBacteria" id="AFK06292">
        <property type="protein sequence ID" value="AFK06292"/>
        <property type="gene ID" value="Theba_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0573"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_0"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
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        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="249" mass="26971" checksum="215BAF875497449D" modified="2012-07-11" version="1">MLKAIIEREVRRYKEEYSPIKRELPENLNIAKFIDHTLLKADATPKMVEKLCEEAIRFEFWSVCVNTGYLPLVNRSLSGSTIRKTVVIGFPLGQMSREVKGFETSWACDNGADEFDMVINVGLLKSGEYESVFDDIAKVVESACGKTVKVIIETSLLTEEEKIVACVISREAGAAFVKTSTGFSGGGATVDDVSLMKFVVGDACKVKASGGVKSREEALAMISAGASRIGTSSGINIVSEGSKENWGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F310</accession>
    <name>I2F310_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate/lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492233.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0594"/>
    <dbReference type="EnsemblBacteria" id="AFK06313">
        <property type="protein sequence ID" value="AFK06313"/>
        <property type="gene ID" value="Theba_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0594"/>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_3_0_0"/>
    <dbReference type="OrthoDB" id="1374098at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="373" mass="41379" checksum="887A090D7B236273" modified="2012-07-11" version="1">MNEIYKDVVWVDFDTLEAFMKDVFVGIGVPEEDAKICANVLITSDKRGIDSHGIGRLKPIYVDRIRAGIQNPITEFEIVRESATTAVIDGHNGMGHVIAFKSMKLAIEKAKRYGMGMVAVRNSTHYGIAGYYPIMAVENGMIGITGTNARPSIAPTFGVENMLGTNPLTFGIPTDEKFPFVLDCATSVAQRGKIEVYARAGKELPEGWVIGLDGRPRTDTQKILIDLTKGEAALTPLGGIGEETAGYKGYGYATVVEILSAALQTGSYLKMLTGIADNNEKKPIPIGHFFIAIDIEPFTQLDDFKKLAGDILRELRKSKKAPGQERIYTAGEKEYEAWQFRKNRGAPLNEVLRKQLVQLRDELRLHRYKFSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F372</accession>
    <name>I2F372_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="10" type="ORF">Theba_0658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730450.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0658"/>
    <dbReference type="EnsemblBacteria" id="AFK06375">
        <property type="protein sequence ID" value="AFK06375"/>
        <property type="gene ID" value="Theba_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0658"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_0"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="278"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="468" mass="53110" checksum="7BF4B327D74AAFDE" modified="2012-07-11" version="1">MKVLFVSYEVYPIAKVGGLADVAGSLPKYLKELGVEIDLLMPFHKSIDKNMAIKTDENISTRFVKREVSFEVYRAKLPKSDVNVFLLYNERLMDSKEIYGASNLGFQAMSFSDAAAGFAVDKGYDIVHLNDWQTALIAVYLKQREAKCKTLLSIHNLAYQGVYGKEYLDLSGIEKSNRNEIFEAGKINFLKAGLVFSDKLSTVSPTYAKEIQTKEYGAGLEDILSRRRSDLVGILNGIDYYEYDPERDERLWANFSQDNIESKKINKSNLQQLVGLPKKDDALIGLISRLVDQKGLDLIEDIKDELMKLPIQIVVLGTGESKYEDMFRILQKNYPEKVAARLTFDLDLAQKIYGGADMFLMPSRYEPCGLGQMFAMRYGTVPIVRYTGGLADTVHEFDPENNGNGFGFVDYDAKKLLGALKKALKVYFQPELWKKVVRNAMRQDFSWRVSAINYLSLYKKILEVNNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G1</accession>
    <name>I2F3G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop ATPase, MinD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730518.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0749"/>
    <dbReference type="EnsemblBacteria" id="AFK06464">
        <property type="protein sequence ID" value="AFK06464"/>
        <property type="gene ID" value="Theba_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0749"/>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067767_0_0_0"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="283" mass="30986" checksum="2991F7A1E0DC8114" modified="2012-07-11" version="1">MVIAVLSGKGGTGKTTLATNLAGAISDEFEVQLLDADAEEPDVHLFFEPNIHHEEGVELLLPVIDNKKCTRCGKCAEVCQFGALSVFQTGVMVFESLCHGCGLCTFICPEKAITERPKVIGKVQTGKINKKIDFGMGILEIGEPSPVKVIRTLKKHINRDRIVIIDSPPGTSCSVVETLRNVDYAILVTEPTPFGLHDLKLAVEIVREMDIPFGIVINRDTGSYTLVDEYASEENFSVLERIPFDRGIAESYSEGKLFVETSPIWKARFKSLAERILSSAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G3</accession>
    <name>I2F3G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730520.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0751"/>
    <dbReference type="EnsemblBacteria" id="AFK06466">
        <property type="protein sequence ID" value="AFK06466"/>
        <property type="gene ID" value="Theba_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0751"/>
    <dbReference type="HOGENOM" id="CLU_2274020_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035205">
        <property type="entry name" value="DUF5320"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17253">
        <property type="entry name" value="DUF5320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="102" mass="11757" checksum="0EB34F7303CB78E3" modified="2012-07-11" version="1">MPYGSGPMRFRDGSCRFYGYGPGYGAAYGRGMGYGRGFGPGRGYGYYGPYDYDVEISPEMERQDLREYQAFLKKELEMINEELREIEKRLETLQNTTSAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J7</accession>
    <name>I2F3J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein with ribosomal protein S1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0786"/>
    <dbReference type="EnsemblBacteria" id="AFK06500">
        <property type="protein sequence ID" value="AFK06500"/>
        <property type="gene ID" value="Theba_0786"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0786"/>
    <dbReference type="eggNOG" id="COG1098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128762_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="13667" checksum="D501FC9AFAC789BB" modified="2012-07-11" version="1">MSVKVGTVVEGSVTSVKKFGAYVNLEGGEEGFIHISKVAREYVKNIEDYLKVGQKVEAKVLGTTKDGKWELSIKDLKGKGSEEAPTSQDFEKKLAKFMRDSGEKISAYKRRLDKKRGIRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L9</accession>
    <name>I2F3L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsI/penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730574.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0808"/>
    <dbReference type="EnsemblBacteria" id="AFK06522">
        <property type="protein sequence ID" value="AFK06522"/>
        <property type="gene ID" value="Theba_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0808"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_0"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="51"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="225"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="569" mass="63224" checksum="6C2723F50C295024" modified="2012-07-11" version="1" precursor="true">MKIKRFDLFFVLFILTVGLFIYKLYDYQIVSSDKYAAQVESISHRSISLLPQRGMILDRNGIPLAWDAPYYNIEKRVVFLPDDLKRMTIDAFDDKQKAETLIKNLEMFGSVEASLPAALAERLNDFPELEVSERVIRYYQNNPGVAHVVGYIKADGEPVMGIEKQYNDLLRGTPGEQLIRVDALGRQISLEGERPPVGGKDLTITIDSQMSKYIYELINETGKSGAAVVMTTSGEILALVSVPGFENMSFTKGISNRDWERLNLDPSRPLVNRALTPFTPGSVIKPFIAMIALAEGKDATEQIDCRGSFQYKDSQGIVQGVYRDWNLYGHGMTDLSKAITVSCNVYFYQLGLELGIDTISNYAEIWDVFEPTNIDLPEESTGLMPCPSWKQEKLEENWFPGDTIQISIGQGYLSITPLQLAKMTGEIATKGREILPYIGTERVSDRAVIELGESDWNLLTEALRNVISKGGGAAEAGTAYSAFRNFEGTAAGKTGTAEQGGSKPTHSWFTGFMPLEEPEIVVTVFVHEGGYGSGLASQISRKIMDYYLQEYMQQNHSTGLTKLSSSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3S6</accession>
    <name>I2F3S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730617.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0869"/>
    <dbReference type="EnsemblBacteria" id="AFK06579">
        <property type="protein sequence ID" value="AFK06579"/>
        <property type="gene ID" value="Theba_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0869"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836277_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="332" mass="36764" checksum="75F5628D1BFEDE80" modified="2012-07-11" version="1">MRDFAISMDSDPDERGDCVFMVVDITRNQTPALVGRTPCQGFYRDLFGIGNYLVCSGNSEVDIYNAAMLPEVSLISHFKGFGGKKIAPDVHRDLIFVLNEVQGVGVISIAEREEPKLLGHIYPGNLSEDLLMTDIALLDNHLLLLVNDLSTSSHRECLLIYDVISPENPQMKEKVSIAPCKGNVLAIKGERLYISGFNNLMIRNVNDINESGRSALVERDGTRGVGLIVYGDLAYLVEHEWALRSTTAFLNVVDLRVSDEPKFMGKTLLTINFLSDYTDVSMRKIGERLILVSSFGLRVIDVSDPANPDITHLFRPSDSSRIASGLEILTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U2</accession>
    <name>I2F3U2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="7" type="ORF">Theba_0885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730633.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0885"/>
    <dbReference type="EnsemblBacteria" id="AFK06595">
        <property type="protein sequence ID" value="AFK06595"/>
        <property type="gene ID" value="Theba_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0885"/>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_0"/>
    <dbReference type="OrthoDB" id="177859at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="555" mass="60020" checksum="BFF85A26C7C3B76F" modified="2012-07-11" version="1">MLTDLEIAQKAELKEIDEIASSVSIPDKHIRRYGKHIAKISHQYLNELQDKPDGKLVLVTAISPTSAGEGKTTTSVGLAMALNKIGKKSFVTLREPSVGPIMGIKGGAAGGGYSQVLPMEEINLHFTGDFHAISLAHNLLSAVIDAHINFDNELRIDPAQLYWPRTMDMNDRALRQIIVGLGGSANGYPREDSFVITAASEIMAIICLSKNLVDLKERLARIIVGRSYDGDFITVKDLNVQGAMATLLKDVLDPNLVQTIEGTPAFVHGGPFANIAHGTNTLTATKMALKLSDYVITEAGFGADLGAEKFLDFVCPVGGLNPSAVVLVASIRALKLNGGASKKDILEEDLSALEKGFENLKVHFENIHKYGIPVIVALNEFPTDTEKEREKFDGLCKSNSIPYERSSVWAEGGAGGVDLARKLVELVDGPSDYKPLIPMDLSFEEKLDKLAKEIYRAGRVDLEPAAKSKLRLFKKQGVDRLPIIVAKTQYSISDDDKKLGAPQGYTFKVRDLNLSAGAGFIVVVAGKIMLMPGLGRDPNAKQIDVDADGKISGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3U8</accession>
    <name>I2F3U8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">Theba_0891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0891"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="AFK06601">
        <property type="protein sequence ID" value="AFK06601"/>
        <property type="gene ID" value="Theba_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0891"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_0"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="205" mass="22834" checksum="9EFEFF888E8878FB" modified="2012-07-11" version="1">MGINMAPFVPYVVEDRGRGERIFDIYTKLLSERIVFLGWPIDDEVSNIVVAQLLFLESQDPEKDINLYINSPGGSITSGLAIYDTMQYIKPDISTICIGMAASMGAILLAGGTKGKRFALPNSRVMIHQPFGGAEGVAKDIEIRAREILYLRDELNKILAKHTGQSIKKIEKDADRDFFMSSTEAVEYGMIDKVIEQKAKVKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Y8</accession>
    <name>I2F3Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730663.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0935"/>
    <dbReference type="EnsemblBacteria" id="AFK06641">
        <property type="protein sequence ID" value="AFK06641"/>
        <property type="gene ID" value="Theba_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0935"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_0"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="158" mass="17065" checksum="701FC2D736811B70" modified="2012-07-11" version="1">MKISFTLNNERLSMDVVEDMRLLDFLRDELGLTGTKEGCGEGECGACTVIIDGKAVNSCLVLLPEIDGSEVTTIEGLSKDGELDTIQKAFVDEGAVQCGFCTPGMIMSAKALLDRNDSPSDEEIMEAIEGNLCRCTGYYKIVQAIKTAAENLRKTNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A2</accession>
    <name>I2F4A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpA</name>
        <name evidence="13" type="ORF">Theba_1050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730760.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1050"/>
    <dbReference type="EnsemblBacteria" id="AFK06755">
        <property type="protein sequence ID" value="AFK06755"/>
        <property type="gene ID" value="Theba_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1050"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_0"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="12">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="11">
        <location>
            <begin position="371"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="9">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="504" mass="55242" checksum="366EEBEB4EE27CB4" modified="2012-07-11" version="1">MKISPSEITKVIQNQLEKTDIEFDYFEAGKVIQIGDGIARAYGLKGVMANELVKFDNGVYGLALNLEEDNVGIVILGGYKEIKEGDLVRRTARIMEVPTGPELLGRVVNPLGIPLDGKGPIDTKSFRPVDVKATGVVMRKPVDTPLQTGIKAIDATIPIGRGQRELIIGDRQTGKTAIAIDTIINQKGQNVKCIYVAIGQKTAALARIIDKLNQFGAMEYTTIVFASASDTAALSYLAPYAGAAMGEHFMFEGQDSLVIYDDLSKHASAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNENFGGGSLTALPIIETQANDVSAYIPTNVISITDGQIYLDPNLFYAGNRPAINVGLSVSRVGGAAQIKAMKKIAGSLRIELAQYRDLLSFAQFATELDKATRDQLTRGEKLTELLKQDQYVPMPVEEQVVVLYAGTKGYLDDLDTSRVSTFETTLLKTLRASYSNVLASIREKKVIEEETEKLLKKAIEETLKLFAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B0</accession>
    <name>I2F4B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730763.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1058"/>
    <dbReference type="EnsemblBacteria" id="AFK06763">
        <property type="protein sequence ID" value="AFK06763"/>
        <property type="gene ID" value="Theba_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1058"/>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137228_2_3_0"/>
    <dbReference type="OrthoDB" id="1925754at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="113" mass="12681" checksum="EB4B78B1C9B259AE" modified="2012-07-11" version="1">MGRLEDFRSFRERMNKRIIETGNIDTKRFFSLDGAVYEDGALDSKTKELMGLVASAVLRCDDCIAYHIIQCKATGSSREEIMEALNVALIVGGSIVIPHFRRAVELLDELEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B4</accession>
    <name>I2F4B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1062"/>
    <dbReference type="EnsemblBacteria" id="AFK06767">
        <property type="protein sequence ID" value="AFK06767"/>
        <property type="gene ID" value="Theba_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1062"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_5_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="190" mass="21904" checksum="45B553F4D9EF3BD7" modified="2012-07-11" version="1">MRLFIFDVGGVVAENTSVVPSISGFLGISKEEFVEIAEMDNLLALQTGRITVEEFVYVFSRKLGRPVPGKIWDMFFKPTPMEETVRIIERLRRKYRVVAGTNTIESHYEIHKSRGDYEVFDRVYASHLIGYAKPDKAFYSHILREENCCAEEAFFTDDTRKNVKAAAELGIVSYHFTDSTALEKRLREYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B8</accession>
    <name>I2F4B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall-associated hydrolase, invasion-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1066"/>
    <dbReference type="EnsemblBacteria" id="AFK06771">
        <property type="protein sequence ID" value="AFK06771"/>
        <property type="gene ID" value="Theba_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1066"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045651_0_0_0"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039439">
        <property type="entry name" value="SH3b1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12913">
        <property type="entry name" value="SH3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3_6" evidence="3">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="304"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="439" mass="49566" checksum="261B2F9E4A3A7710" modified="2012-07-11" version="1">MEKYIATPEGVLPEKQESDYWCRRMENPDAVWMLKDEIESFNSAIILRAREAGKLEFACSLEDCPSSVPFEEVRRSINDTIPETFFQRSLLTSEGDKVPAEIRNDIIDNATAILNQDMAVRFGLVTQRTNLRVLPTDLISCDEYIDNDMLQLTAVSIGTPFALLARSRDMSWLFVQTPFYRGWIKANDTATAKKRGAVMSFMKASPFLLATGNRVEIEPDPFAINSLGLILQMGDRLPLEKPTENENLHAQGPFSCFTVSVPYRDRLGLLGFRKALVRMSEDVRIGDLDLTGRAILDQAFKMLGERYGWGDLYNRRDCSRFVRDIYASFGIFLPRDAWAQERFGSSNKVVFEGDAEHRKSQLSSLRPGNPLYMPGHTLIYLGEENGSFFAIHDGAGYRDSKGKKVSVHGVFVVDLSVRTMNSDKSYLEQLTTALRIDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4F1</accession>
    <name>I2F4F1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flg_new_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730801.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1099"/>
    <dbReference type="EnsemblBacteria" id="AFK06804">
        <property type="protein sequence ID" value="AFK06804"/>
        <property type="gene ID" value="Theba_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1099"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442663_0_0_0"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="617" mass="67466" checksum="49B65D2111D332CC" modified="2012-07-11" version="1" precursor="true">MRRTFLFLIVLSLAIIFLVSCPALKYALTIQIGGSGTTDPSEGVHEFNKNQVVTVKAFPESGWQFDSWEGEVSTPDSTTTTVTMDKSKTIKAVFVLDQIGIIIDKLDPLTPLSFRHGEELILLVPNNIQRFLNLLEDDDPLNRWAAAYALQRNQLDQSTLDDLEDYLDDENLTIRALIAVAFLLSGDESGKSVLVNLLTEDTVMMYSIPPVLLSDFAEVILNAYYPAEYPLTSFSPQTTTVSGGPCEYTVTVKVVFHGAGASETQVEAWETDAEAIWNGADDSREWGDGCCSVKFEFDFSVLAEGAQPPDDAHVVEVKKVKSSHTSWVATPLPTPGSTETTTGEWDSLDTGPVIAHEMGHMMGLDDEYHNDEDGNYVNDNPQPEGSPPSIMAQTWGGAQPLTEHFDAIMEAADIECDCDYTLTIDPPYDVNISPGSHTVTVTVAKEDGKPAKNCDLTLNITGLHPKSDVKLKTDDAGKSQYTYQCVRPDHTGIDNINVTGECGALGDAVKKWIALWDLFPFGITPFDGQEDYPYSIPMAIIFGVEPALALEAENLAFNVSVMMGTETLFSTKTHHTEIETPLLLEPGSDFTLEIVPISLPDTEGTPTVINFSTLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G7</accession>
    <name>I2F4G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486317.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1115"/>
    <dbReference type="EnsemblBacteria" id="AFK06820">
        <property type="protein sequence ID" value="AFK06820"/>
        <property type="gene ID" value="Theba_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1115"/>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_9_3_0"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="90" mass="10404" checksum="BBE97D3D47F50FB2" modified="2012-07-11" version="1">MELVKAGRSRQVTIPKQIFDSLGLKEGDYVQVEVEEGRIVLTPVAVINKERAKSDFFQLVQRVRTNAESLTEEEIEEEIREALEESRRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J8</accession>
    <name>I2F4J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family (UPF0150)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730842.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1151"/>
    <dbReference type="EnsemblBacteria" id="AFK06851">
        <property type="protein sequence ID" value="AFK06851"/>
        <property type="gene ID" value="Theba_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1151"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184590_0_0_0"/>
    <dbReference type="OrthoDB" id="2012308at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="69" mass="7930" checksum="2A29064E8AEA02E2" modified="2012-07-11" version="1">MDTEIIFLIEEDSVSGFFARALGHPIFTEAETLEDLKKNIRDAIGCHFDESELPRIIRLHFVKEEVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4L5</accession>
    <name>I2F4L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730857.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1170"/>
    <dbReference type="EnsemblBacteria" id="AFK06868">
        <property type="protein sequence ID" value="AFK06868"/>
        <property type="gene ID" value="Theba_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1170"/>
    <dbReference type="eggNOG" id="ENOG5032YWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_0"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="122" mass="14073" checksum="18059496E963E96B" modified="2012-07-11" version="1">MFYKDLDVYKKSIDFVVDIYKTTESFPESEKFGLISQLRRAAVSLPSNLAEGSGRNGRKELINFLHLARGSLFEIGTQLEISHRLRFVSQENYAKLEERRATIQRMMNALISSLRKKGENND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q3</accession>
    <name>I2F4Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730893.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1209"/>
    <dbReference type="EnsemblBacteria" id="AFK06906">
        <property type="protein sequence ID" value="AFK06906"/>
        <property type="gene ID" value="Theba_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1209"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044700_0_0_0"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="107"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="481" mass="54878" checksum="36A9101F54985724" modified="2012-07-11" version="1">MGIVESMKTSMLRQAGKYVGSVVRNSSTENIARLFGTVAALTKEPTKSGLKKLTQMAKEEHPMIVSWQNVFKRSSPKAVEKAMTNLVVNEFALGEKIRQEKMLEHEVVIPKLVVISPTYACNLNCVGCYAGLYGRKYQLSKEEVSSIIRQSNELGIYFFIITGGEPFVWPHLLEIFEEFNDSYFQVYTNGTLITKEVAQKLAELGNATFAVSVEGFEGETDWRRGRGVFQKVRQAWTNLREAGVIYGTSVTATRLNHEVMMKDEFWQFLKDEGVSYAWVFQFMPVGMNPSMDLVPTPEQRYERFYKTEQERLGGDFAFVADFWNHGFLTNGCLAAGAKYLHVNAKGYVEPCVFQQFAVDSIREKSLLEVIKSPFFTAYKRMVPYSNNLFRPCPIIDNPKVLRAMVNKFHAIPQHDGSENVVTELAGQLDELAEGWKKYADKLYYEEGFAETHPAHRGVYDFDVRMRKYANNEEKLAIDKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T3</accession>
    <name>I2F4T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730917.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1248"/>
    <dbReference type="EnsemblBacteria" id="AFK06936">
        <property type="protein sequence ID" value="AFK06936"/>
        <property type="gene ID" value="Theba_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1248"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_4_1_0"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="430" mass="48084" checksum="2CC99982B8D0B8FF" modified="2012-07-11" version="1">MARGKDYTVSLDVGTNTLKGVVVSREQTGEMTLEAYGSVKTVGLDKGEVKDAVALKQSIQKLIEDLTGQMGKKDVEADFKISFTDGDYSVFSQNIEEVLSEDKQVMVKEQTIVGLMSRLKAEKMKTGNTNIHRSYIRKYILDDDKVVFNPVEMYAKKLNVEMVFVSSEGKSVEIFRRLFEELFGRGDFFISPALISASEAVLTDTEKQHGVVSVVLGHSFSEMVIYRENLPVYISRIPLGIRHIVLDIARVLGTSVDEAERLLVNYGHCSMFPPDAEDVVEYFGLDERTRKNVSVRRLSTVIYARVKELLNKIRKEIQLFVINNPEYSEERIPGGVVFTGGGSKLRGLTDVGVESLKMPVRIGTYETSFNRRIENSHDVANDPIFSSCLGNLVSPEEIQGEAVESVVERPKKGFASFIRSLFFGGVDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V0</accession>
    <name>I2F4V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730934.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1265"/>
    <dbReference type="EnsemblBacteria" id="AFK06953">
        <property type="protein sequence ID" value="AFK06953"/>
        <property type="gene ID" value="Theba_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1265"/>
    <dbReference type="eggNOG" id="ENOG5033XTQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949316_0_0_0"/>
    <dbReference type="OrthoDB" id="2130914at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="33223" checksum="BA68359C9F00A516" modified="2012-07-11" version="1" precursor="true">MKKLSVLVVLLLVVGLAVGKDAVEELTTLIDVLKNSSYEVDRYVQESGIVTTAKNERVIKSGPYKLVTSYSSAKGEFGWVRNSSGHFAIFRTRSIAFEPLTKIKDVEDNFIDLVNRKSYVVDLFLDLPNSRKITISSGNLSFEVTYDDSYKLLKLVKSYPFHTISASYRNYSEMSHEALSKLSNATEGMIIIRPPIYFSEAMLEKHFAWSSMDFATDGKTYLYTVLMYSIEYGRMVLYFSFNTEPDYLQKFSAQMAQANGYSYAIERLSENSAISLLGMIDTETLSSLLEDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Y4</accession>
    <name>I2F4Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SagB-type dehydrogenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730961.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1299"/>
    <dbReference type="EnsemblBacteria" id="AFK06987">
        <property type="protein sequence ID" value="AFK06987"/>
        <property type="gene ID" value="Theba_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1299"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059362_3_0_0"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="28673" checksum="FD33BA30FF3B2AAF" modified="2012-07-11" version="1">MIDRKEGRAFLSNKIWEEVDRQLKKTDQMEGKPQPPLEKSSEGYELIKLPDPNAVNLHMKDLKEIIFSRESRRIFSDDKISLESLSFLLWSTQGVKGVLKNNYATLRTVPSAGARHPFETYLFVRLVKGLKKGLYRYVALSHSLIFLKEGDFAKEVAEAALGQKFVGQCAVTFVWSVIPYRTEWRYDLTSYKPILLDAGHVCQNLYLACEALNLGTCAIAAYDQTKTDELIGLDGYDEFAIYMAPVGKPKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F581</accession>
    <name>I2F581_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731029.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1396"/>
    <dbReference type="EnsemblBacteria" id="AFK07084">
        <property type="protein sequence ID" value="AFK07084"/>
        <property type="gene ID" value="Theba_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1396"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_0"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="391" mass="43452" checksum="C97D9483B4880C58" modified="2012-07-11" version="1">MVGKKLDSENIGRSNRKLILQLLRKNPATTRRDLAVASGLNPSTVTKIIKDFLSMGLCEEVRAEETGRIGRKAIVLRLNRKAFMSVVIDIGVEETIIGKGFFDGSVSVVSRFRTPRDFDQFMDLLTKKTSLISRNIPKSRFLGYSLSVPGIVDVENSRIVYVPHLGWKDLVLRERLSRRYPVFLDNEANLSLIAEKWNNPDVVSVRDIVFVYVSEGIGCGVMFDGQIYRGRDYSAGEFGHMTVQIDGKKCYCGNFGCWETIASTEAIVNLATELGLELKGTSNNEKYLNCLRSTDASYEPLLREIERSLGVGIVNIVNSLDPEVVVLGGVASILPEVSLRNLLDFVNSRVLYATGQNVKVIRSMLHEKGMASSKMIGAALHIIDRKTVDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A0</accession>
    <name>I2F5A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731048.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1417"/>
    <dbReference type="EnsemblBacteria" id="AFK07103">
        <property type="protein sequence ID" value="AFK07103"/>
        <property type="gene ID" value="Theba_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1417"/>
    <dbReference type="eggNOG" id="COG4795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1446098_0_0_0"/>
    <dbReference type="OrthoDB" id="2050487at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="187" mass="20848" checksum="8697916741C71A1E" modified="2012-07-11" version="1" precursor="true">MERTRAGLTLVELAVVLAVFTIVLASVLLMFTDLTRRSRIALGEVERYSELFRVDSLIQAELSKAGPNVEKITLVRESEEGPAKGLRYMVSLPFVRGKVTKQFYIDEGRLFIWEKQSGQGDFPADSTADVIESFDKSEDIIFSSSSFDHVDLEFESVDGGSVSYSIMLSSPDGTRTHRSSVRLINVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C1</accession>
    <name>I2F5C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.101</ecNumber>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Theba_1438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="8"/>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1438"/>
    <dbReference type="ESTHER" id="9bact-i2f5c1">
        <property type="family name" value="PAF-Acetylhydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07124">
        <property type="protein sequence ID" value="AFK07124"/>
        <property type="gene ID" value="Theba_1438"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1438"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709422_0_0_0"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK07124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="389" mass="43167" checksum="263F72365A88B5D6" modified="2012-07-11" version="1" precursor="true">MKTKGGYSTIVAIFGILMGVIAILNYLFPLNHMPLPDGPHNVGFRSYEVSNPQPMSVAGINYSDPGKIRLEVWYPAGDVSTAPRKGWIDNDPLVFQGFEIVTGYPEELFEHIYRVKTNSFIDAPPVDDSSTWPIIILLLGWSSISELHTSLAESLASAGYLVVGIEHPGACAVVSFSNGDVHYFLGNDLLERLPEGTRESKVRMLSEYLARDVNYAIEYLNGMNEDPSSDFFERLNMNEIGLYGHSGGGAVAIQYALANKDVPMVLADPTLEGFSVQELDTAFSNKILLMSTEEWEHGISEEYSSTIAKERNESLYNLRICGMRHVDFAMVRNLSPLTFFFGETGRFMNDEDAIGYLDSAVKLFFDSVFFGGGIEELFALSESVPEFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5D5</accession>
    <name>I2F5D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K+ transport system, NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486984.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1452"/>
    <dbReference type="EnsemblBacteria" id="AFK07138">
        <property type="protein sequence ID" value="AFK07138"/>
        <property type="gene ID" value="Theba_1452"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1452"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_4_1_0"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0630">Potassium</keyword>
    <keyword evidence="1" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="16529" checksum="FE47C26E26C10AC5" modified="2012-07-11" version="1">MPFMKGAIKKDEYYVVIFGCGRLGSRMANWLSSLGCSVVIVDRNESSFDALSNEFTGFNILGDATELDVLKEAKLDKADVALVLTTDDNTNLMVSMSAKEYFEVPRVVARAYDPNNIKMFSDFGIEVICPTLLAVESIKSALYFIGGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P0</accession>
    <name>I2F5P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731150.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1571"/>
    <dbReference type="EnsemblBacteria" id="AFK07243">
        <property type="protein sequence ID" value="AFK07243"/>
        <property type="gene ID" value="Theba_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1571"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382102_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="724" mass="79681" checksum="084AFC4374BB44FD" modified="2012-07-11" version="1" precursor="true">MLKYIWLYFRRRPGRILVFIIVVALGVAVSIVLSSIFLSFGETRSRISKINENWITVQYLSDTGRKEEIDDSLKEIFADVSGISDVIQVDIAYLGYNLFGSARANFPVYGIKQTDIARILQVSQSYIVDGRIFSPKTNEIMVSDSFLKASGVGIGLVYEEIFETASTGLYNVVAALKGPSVFGIGPSGISGGKGAYGFIVLSERGFSIAVESELRSRIAGEELKVGVQGPISSRENIERSYSGYYLGVLLCNLCVALVFIIGLTMLNSVSIRERRKEYGILAAIGHSPASLGARLFFESVYQCAAGWIIGLFAGRILVSYLETRFFEPNGLFVGDIFVSTIWTLVIPAVTVVFTQVLIGSHLSRDLVGLLKSSEKKKGILKNRFKNISLPWLRFPLRSDGYRSLFVNIIVFALLVTLFGSLLSSLTDTIRDSGRFFDSCSYVQTMESGDIELPEEIVSRSRAVLPASLLNLDVKLIFGTTEIFIPVVSSKDSELVQTLVGDTSENAFYVSKGLFDLINSGEVNGYGNSSPVVLPSLYGLSGIVVEQEVAAEGLLIFHAGDDLVEEIRLFASEAGVAEVVDRRSFETKILKESQFMNLITSIIIYLQFFVVVIIAVVTVTRIVLGRRRELAIRNIIGQGRGEIALLLFGELILVLFSGATIGFILGTMSWSIFKAFFLSGVYISSFVAAKVFLKIFIMILIVLFSGLAMERYLISKQDPLSIIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P2</accession>
    <name>I2F5P2_9BACT</name>
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        <submittedName>
            <fullName evidence="4">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731152.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1573"/>
    <dbReference type="EnsemblBacteria" id="AFK07245">
        <property type="protein sequence ID" value="AFK07245"/>
        <property type="gene ID" value="Theba_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1573"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="262"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="451" mass="50958" checksum="1B9B7EB340C43645" modified="2012-07-11" version="1">MNIDGYRDFLSLLRNGIILCELTFEGRCKVIDANPAALETEGLTREAAIGMDLEHLFPPAREFSVMDGVRRVSETGIPLHIGSKHNPETRSEIWRDVSISRLSSNVIAIVYNDFDESSEARKDLKKSKLELDRLFSNLPGIAFRCKNDKDWTMEVLSGGLVDLAGYRPEEIIGNKKLSYADLIFSEDREKVWKSVQESFTRDDHYEIEYRIVTKSGIVKHVLERGKVIKNPGEDQSFVEGFISDITDLKAAKIEIEESKERLENTFKSTVNALSKITEIRDPYTSGHQRRVGLLAEAVSRKMGLERKLCENIRISGLLHDIGKLWIPSEILSKPGKLNKIEMEMIKEHPRLGSEVLKEIEFGFPIAEYVIQHHERMDGSGYPNRLKGEEISLPARIIAVSDVVEAISSHRPYRPALGLNVAIEEITSGARTLYDPSVTRACVDLLKNGFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F669</accession>
    <name>I2F669_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731263.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07422">
        <property type="protein sequence ID" value="AFK07422"/>
        <property type="gene ID" value="Theba_1767"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1767"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48636" checksum="A246C16C04BBC102" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWQYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLKLHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTFRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSRLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F683</accession>
    <name>I2F683_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731270.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1785"/>
    <dbReference type="EnsemblBacteria" id="AFK07436">
        <property type="protein sequence ID" value="AFK07436"/>
        <property type="gene ID" value="Theba_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1785"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039395_0_1_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="469" mass="52542" checksum="3886782F23804A0F" modified="2012-07-11" version="1">MIGFLAIDIGASSGKAFVGKYGRNRLVLEEVHRFSNEPIHVADLTHWNLISLYKNVVESIKAASAMGIEIRSVGIDTWGVDFGLIDSSGSIQGDPRHYRDMFKDDSMDYAIKKAGKRWIFDRAPTQFQPFNTLYQLISLKRNNSRYLEKADALLPMPSLLTYFLTGEKLTEFTFATTTQLFDPDRNDWSEELIRFFDLPDIMTPIVDPGEIAGELLPSVAEELGIKGLKVILPASHDTASAVSSMDLSDDSMFVSAGTWCLEGVLIDKPSRNDDVIENNLANEGCYGRRYRLLKNLTGLWLVQELLKEWRRSDPNLDHYALTEMALTVRSYERKIDVESEAFRKPRSMEKAILSEAEKLGISLKNRGEIVRAAIEGIAYQTEQTRKQLQSITGRSIRNIRMVGGGIRNSLLCQLVSDYTGLPVVAGPAEGTATGNIIVQMLGLGELSDLSQAHDLIQRSFNFQEYTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F696</accession>
    <name>I2F696_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monovalent cation/proton antiporter, MnhG/PhaG subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731280.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1798"/>
    <dbReference type="EnsemblBacteria" id="AFK07449">
        <property type="protein sequence ID" value="AFK07449"/>
        <property type="gene ID" value="Theba_1798"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1798"/>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_6_0"/>
    <dbReference type="OrthoDB" id="2051355at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="114" mass="12104" checksum="3A057A8B3AB41C4B" modified="2012-07-11" version="1" precursor="true">MIILDIVGYGLLSVGTFFFFLGGLGMLRMPDVFNRLQAGTKATTLGSFSVILGVGLINPQWLLKTIIIVAFIAITNPVGSSAIARTALKKGIIPITYQESHKEPDGLPKGGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6A6</accession>
    <name>I2F6A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADPH-dependent glutamate synthase beta chain-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731289.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1808"/>
    <dbReference type="EnsemblBacteria" id="AFK07459">
        <property type="protein sequence ID" value="AFK07459"/>
        <property type="gene ID" value="Theba_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1808"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_0"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="609" mass="67543" checksum="C2A4CA2DFD5FB168" modified="2012-07-11" version="1">MSVYDDFKKTFWGPTVAWKRLFTKPVTIKVPQVYREAAERYRGFHVNDWDKCSGCGTCAKICPTDAIKMVPVDITVDIGKKAQRPAIDYGRCSFCGMCVDICTTGSLNMTREYIHISDDPDSFFFLPDETGIHHDSQPIGYSRDENSELLDLERVEMEELSGEERVQSFIEFVKGFSKEQAIAEAARCVDCELCIDACPAKMDIPRYIESVFKNDTKKGVEWIYRTNPLPSVCGRVCTHKCETVCSIGNRGEPVAIRWLKRYLMDQEKTEDVIRYAKEQEIVRKGSGRVAIIGSGPAGLSAAYYLSLMGYSVTVYESKEHAGGVMRYGIPRYRLPDEALDADLEVIEALGVKIECGKTVGKDVTIEHLHEKFDAVFLGTGFMKGRSTGVKGADSEGVLMAMPLLESIRDYLRGDSSKKPEVPESLVVIGGGNVAMDVARSVARLQKMEGMPIDVKVTCLESSDEMPADLEEIVEGREEGIKFFPSRGPKEVCLKGGKVFGLSTIACTAVFDKDGRFNPRFDESDESMIEGKMIVEAIGQAPDYDYLPESIREKIQFVRGRILVNEKGQTDLPWLFAGGDIVNGPDIIHGVADGHKAAVGIDEYLSKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D5</accession>
    <name>I2F6D5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731306.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1837"/>
    <dbReference type="EnsemblBacteria" id="AFK07488">
        <property type="protein sequence ID" value="AFK07488"/>
        <property type="gene ID" value="Theba_1837"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1837"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_0"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="217" mass="24550" checksum="045516E5C19572F3" modified="2012-07-11" version="1">MIAENVKRLRSEIPDYVTIVAASKTRTASEILEILESGLKDVGENYVQEAEGKFEAIGNKARWHCIGHLQRNKVKRAIEIFDIIQTVDSFKLAEEIDKRCSYLSKKMPVMVEVNSGKEENKAGVLPENVLQLITEISPLKNIAVVGLMTMGPFTEDPEEIRPSLRLTRRLFEEISKEKIEGVEMKYLSMGMSNSYRVAIEEGSNMVRLGTIIFGERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J8</accession>
    <name>I2F6J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731353.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1903"/>
    <dbReference type="EnsemblBacteria" id="AFK07551">
        <property type="protein sequence ID" value="AFK07551"/>
        <property type="gene ID" value="Theba_1903"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1903"/>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046648_3_0_0"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="35522" checksum="CA8BBC2F091AEAAB" modified="2012-07-11" version="1" precursor="true">MKRSLVIVLLFSCVIGVAVSIDFESLYTMERASDFPLLMPQGIEWESKAVFNPAAIMVDSTIYLLYRSEDWSGTGRWNGTSRIGLAKSTDGFEFTREPSPLIYPTEPYEIPGGCEDPRIVKIDDLYILTYTGYDGGKARLCIATSKDFAEWEKLGPVFKDDTWSKSGAIVPAKIDNKYYMYFGDSSIKLAYSTDLKNWTIFPRPVMEPRQGSFDSRLIEPGPAPIITDEGILLIYNSADFSTIYRPGAALFDIENPRKIIKRTDKPLAEPELSWEKQGQVPNVIFIEGAVIKEDRLILYYGAADTYIGAFVVDLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6M1</accession>
    <name>I2F6M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1928"/>
    <dbReference type="EnsemblBacteria" id="AFK07574">
        <property type="protein sequence ID" value="AFK07574"/>
        <property type="gene ID" value="Theba_1928"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1928"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101297_2_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="159" mass="17050" checksum="553F1B36375727E0" modified="2012-07-11" version="1" precursor="true">MYSTVIYFITGSLLVISLIVSRKKTLMALEKAWRSFEGILPELIAILLFVGLLIALLNPETISQLLGESSGVWGLLIASAVGSITLIPGFVAFPTAVMLLDNGAGITQIALFISTLMMVGVVTFPVEKKYFGSRLTIMRNVMAFGFSFIVAGLMGVILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P3</accession>
    <name>I2F6P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488159.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1951"/>
    <dbReference type="EnsemblBacteria" id="AFK07596">
        <property type="protein sequence ID" value="AFK07596"/>
        <property type="gene ID" value="Theba_1951"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1951"/>
    <dbReference type="HOGENOM" id="CLU_2220006_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="106" mass="12247" checksum="1370400D68D9DAAF" modified="2012-07-11" version="1">MFEKIDYWVSAASYSDRNGTWLLEAALIHPNIGESHDYGEEWTREEIIDKCDVFVFCLITKDAKGNWKRGGQLRKIETDKGVFIRVDGLEKTGDYLGDIPFIEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q5</accession>
    <name>I2F6Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488123.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07608">
        <property type="protein sequence ID" value="AFK07608"/>
        <property type="gene ID" value="Theba_1965"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1965"/>
    <dbReference type="HOGENOM" id="CLU_3170082_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="47" mass="5309" checksum="36B7DCBDADBDA21D" modified="2012-07-11" version="1">MLRVVKNDGTMLLFPTKCDSANNIHRSLTGKGFERIRFEQPGAGFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U7</accession>
    <name>I2F6U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731434.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2007"/>
    <dbReference type="EnsemblBacteria" id="AFK07650">
        <property type="protein sequence ID" value="AFK07650"/>
        <property type="gene ID" value="Theba_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2007"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_5_1_0"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="274" mass="29618" checksum="650D8DA4261151C3" modified="2012-07-11" version="1" precursor="true">MKNFGVLIVILLLAGTMLGSTLVIKGSNTVYPVAQLWAEGFKAMNPDVEISIEGAGSSTGIKALFNGQTDIANSSRWIKASEIEQMNSDGKYFIPYVVAYDGIAIIVNKSLGISNITIQQLFDIYSGKITSWNQIDSSLPKARIVPLSRDNASGTFEYFVEHVMKGEKFAPQVQQLASTRAEVEQVMQNQYAIGYIGMGYITEEVKALTVEGVEPTVANVNAGSYPISRPLFMFVDATNGLPTGVIGEFLRYALSPEGQAAVLSVGYVNAYGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V4</accession>
    <name>I2F6V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UV-damage endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731440.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2014"/>
    <dbReference type="EnsemblBacteria" id="AFK07657">
        <property type="protein sequence ID" value="AFK07657"/>
        <property type="gene ID" value="Theba_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2014"/>
    <dbReference type="eggNOG" id="COG4294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017168_0_0_0"/>
    <dbReference type="OrthoDB" id="1036440at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="PTHR31290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="298" mass="33973" checksum="6EB72271EBE98533" modified="2012-07-11" version="1">MKIGYPCINTTLSCTSAKTFRLASYSEERLIKTVSANLDCLEEILEYNRKKDILFFRISSDLIPFASHPVCKAKWENIFRSRFESIGDRIKNYNMRVSMHPDQFVLLNSPRPDVVSNSNAELLYHAKVLNLMKLDGSAKIQIHVGGVYGDKKEASRRFIDKYNAVPEAIKERLVIENDERLYSLSDCMAINYETGIPILLDVFHHSILSDGISFADSLSLSGSTWSDEDGIPIVDYSTQQEGARKGRHTDSIDLHNFTSFLEKSLPFNFDIMLEIKDKEKSAEAAIRVARKDERFQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V6</accession>
    <name>I2F6V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07659">
        <property type="protein sequence ID" value="AFK07659"/>
        <property type="gene ID" value="Theba_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2016"/>
    <dbReference type="HOGENOM" id="CLU_1308934_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657805" evidence="2">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="210" mass="23958" checksum="A4A15150B7A25737" modified="2012-07-11" version="1" precursor="true">MKKKFVLLSLLVIFAVSAFAHVPAFLTSDDFAKGAFLVRDIDLSQIFYYVFSAAEKITFVFEGFVGQHFHMLFGVPKEIEGMDSTMDFRPEVTVYDPDGEIVEDFVLESIEPEIMYEFFGDTYSYLYVRHDSTLAKKGIYSIKVKAEDPGRAWITFGKKEKFTASQIIAVPRWIREIRSFHYLKGLAKWELYGLGIIGAISAALVLLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6W8</accession>
    <name>I2F6W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731452.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2028"/>
    <dbReference type="EnsemblBacteria" id="AFK07671">
        <property type="protein sequence ID" value="AFK07671"/>
        <property type="gene ID" value="Theba_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2028"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063353_0_0_0"/>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="237" mass="28023" checksum="46901DA2201C9572" modified="2012-07-11" version="1">MDIKCIIKERQGALAEWLNVLNECIICGSETREIYNRTLKVKYHHCGNCEFISKDPADWISEEEELKIYNRHNNSIEDPRYVAFFKDFIDSAVVPFLSKGRRGFDFGSGPSPVLATILERDYGFKMDIYDLYFSPNEVFKGKKYNLITSTEVFEHLAEPVKYFRMLSGYLEDDGLLSVMTLFHPQDHQQFLDWYYMRDMSHISFYTVRTMQVISDLVGLELLFTDRKRYTSFKLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F719</accession>
    <name>I2F719_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731499.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2088"/>
    <dbReference type="EnsemblBacteria" id="AFK07722">
        <property type="protein sequence ID" value="AFK07722"/>
        <property type="gene ID" value="Theba_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2088"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="324" mass="33939" checksum="6E122FF8A526BA1A" modified="2012-07-11" version="1" precursor="true">MAGENVKRRFEYERFGPLIALAILFVISAIASPYFLQTQNLLNILRQVSYTGIIALGMTFVIISGGIDLSVGSMVALVGGVVILALNWLLTVFGEGGEAWAILFALIIGLLFGAGLGALNGLMVTIGKIAPFIATLGTMAIFRSMALYIGSAGVFRSESNLFPDLGMGNVLGIPNPVVVFISLAVIFAIILNKTRYGRYLCAVGSNPKVAKYSAIKVNLTRFISYVAVGITVGFSAVFLSARLNSMSSTNGGLNYELDAIAAVIIGGTPMTGGAGSIFGTVIGAITLGIINNMLNMLGVSPYLQGTVKGVVIIGAVLIQRKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F751</accession>
    <name>I2F751_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_2120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731524.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2120"/>
    <dbReference type="EnsemblBacteria" id="AFK07754">
        <property type="protein sequence ID" value="AFK07754"/>
        <property type="gene ID" value="Theba_2120"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2120"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_0"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK07754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="433" mass="48945" checksum="ABC80DB4B0658546" modified="2012-07-11" version="1">MIERYALSPLKDLWELRAQYERWLEVELAVVAAYEKTGLVPQGTHDKIASSARVDLDSILKIESEVDHDVIAFIKSVTQNMGDEARYFHLGLTSSDVVDTALSLAITESGKLIIHALEKLSEALKERAVAYKDVVCMGRTHGVHAEPTSFGLKLLSFYVEIKRAIDRLKKATENCAVGKLSGAVGNYANISLEIEKIALAELGLKPTVVSTQVIPRDVHAEFFTGLAIAASSIERMATEFRHLQKTEVLEVQEPFREGQRGSSAMPHKKNPIICERLTGMARIVRSYVLASLENISLWHERDISHSSVERIIFPDATMLLYYMAERSAYLVSNLVVYPDRMRENFKASRNLVFSQRVMLSLVDRGMSREDAYQLVQRLSMNCWNNGLDFKEVVLSNEEIAQYLDSEEAIRLFEPEYYLRNVGQIFERAFDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F765</accession>
    <name>I2F765_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2134"/>
    <dbReference type="EnsemblBacteria" id="AFK07768">
        <property type="protein sequence ID" value="AFK07768"/>
        <property type="gene ID" value="Theba_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2134"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="326" mass="36931" checksum="F241E2BE7636F621" modified="2012-07-11" version="1" precursor="true">MYFLKRFLELIPIFFAISIIIFVIMNSMPGDPLLQMRMQNPRAMTNDPERMKELREYYHLDDPLPVKYFTWLKSVLTGDLGYSSMYKSPVIDLIASRLPNTLVLTITAWLIGLVFALPIGIISAVKKYSTFDYATTIFAFIGISLPGFWFALIAIIIFSVNLGWFPVSGMATYGITGFWNIFADRVRHLVLPAFVLGLVQVASWVRYIRTSLLEVLDQDYVRTAYAKGVPDRKVIIKHALKNAMIPIITIIALDIPYFFGGALIIETVFSWPGMGRLMYNAVISSDYNLAISCLMFLAIITLISNLVADFLYVMVDPRIRMGRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F773</accession>
    <name>I2F773_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731544.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2142"/>
    <dbReference type="EnsemblBacteria" id="AFK07776">
        <property type="protein sequence ID" value="AFK07776"/>
        <property type="gene ID" value="Theba_2142"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2142"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_646900_0_0_0"/>
    <dbReference type="OrthoDB" id="667641at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="222"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="424" mass="47627" checksum="67ED896F8CC7DFA3" modified="2012-07-11" version="1">MIDKISRQLKSVAISGWKIKEENVESEEYFFVKDKVDLGRSKKVSKYEVTLYKDFEDKNEKYRGSSVFYISPGMEDAEISEAIEEAFFAAGFVKNPWYPLAPALSRKFCSEEYELSELASEAVGAVFSQSKPVNSWLNSVEIFVIKNRDRILSSEGVDVSLSKYRTYIESIVSSSGREEVELYDQLLLSVPDHERISMRISRLLEMVRERANATATPAVKGVPVILTGEPAKEALRYYLMQSNAHLKYDKISEAELGNSVQSEEAGDRITLEVVPELEGSYYSLPFDNDGLLMKKRKVIENGILNSFWGDIRYSYYIGIEPTGAAMNFSVGEGSLSVEEMRKESHLEVTHFSAVDVDETTGDFGGEIRLGWYFDGSKRIPVTGGSVTGNLKSLDSLYLSRETELNGDYYGPVSLMMKGMKISGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F774</accession>
    <name>I2F774_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731545.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2143"/>
    <dbReference type="EnsemblBacteria" id="AFK07777">
        <property type="protein sequence ID" value="AFK07777"/>
        <property type="gene ID" value="Theba_2143"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2143"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183917_0_0_0"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TM1586_NiRdase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="221" mass="24902" checksum="99CFC4E208055ACD" modified="2012-07-11" version="1">MIIETIKMRHSTRKFLPYGLSSEERERLVDFFEVIPTLHSLRLKWALKDLNKGSSAIYAPCTNKPNCLVEYGFQGEIIVLEVTKMGFGSCWNAGIREAGSPAGIIIGKEDQGKVSINDILTGMGRRKELRALIDGPVPEDERLLQILESCRLAPSSMNRQPWRFSVLEGDLYIWTKANMIGGGHWLDLGIVLSHAYITALEFFKNVSIEKAAGDRYRVIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F786</accession>
    <name>I2F786_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731557.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07789">
        <property type="protein sequence ID" value="AFK07789"/>
        <property type="gene ID" value="Theba_2156"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2156"/>
    <dbReference type="HOGENOM" id="CLU_1341960_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="204" mass="22841" checksum="B700CD2851E1430A" modified="2012-07-11" version="1" precursor="true">MKRLLLFFSVILIIFLGSSCLYVISVPIPVGEGLIEPIEFELPGSILPLSGFAFGTETVPSLDEIIQEAEKETQLNLPDNFVITGMEIKARVEWVPENPDSEGSIDIDFYVFRERHSEEQFLDFFNDPDLISDRKLFSGLIYPGENTFRLHSGESAALDMILEIINGGTAEDIDWFAIYDYEAPSDSTITIHLSGTISVKRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F788</accession>
    <name>I2F788_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine/D-amino acid oxidase, deaminating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731559.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2158"/>
    <dbReference type="EnsemblBacteria" id="AFK07791">
        <property type="protein sequence ID" value="AFK07791"/>
        <property type="gene ID" value="Theba_2158"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2158"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_1_0"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="382" mass="42537" checksum="85C38385860642AF" modified="2012-07-11" version="1" precursor="true">MVMRSKYKVVIIGGGIVGTATAFYLAKSGLNDVVVIEKEYLSSGSTGRCGGGIRQQWSEKSNVRLAIRSVKHFKEFQKEVGFDIEYFQGGYLLLAYTDEEVSLFEKNTKMQREEGLDVLMLSAKETAKRFPLIDLKGIKAAAYCPSDGHANPHLTTFAYAHAAKAMGVDFSTHTTALRILTQNERITGVVTDRGKIEAEIVVNAAGGYSREVGAMAGIDLPTESYKHQIFVTEPLEHMLDPLVISFENNFYIRQTKSGNFIMGQGSKDELPGHNIEPTWTFISEMAKKMPGIFPFLRNVRVLRHWAGLYNMSPDARPIIDRSKDLENFFYAVGFSGHGFMLAPAVGEAVAEWIIYGEPRSADLSDLSLERFEHGITKERNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B1</accession>
    <name>I2F7B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of ABC transporters with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731579.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2181"/>
    <dbReference type="EnsemblBacteria" id="AFK07814">
        <property type="protein sequence ID" value="AFK07814"/>
        <property type="gene ID" value="Theba_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2181"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_0"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="337"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="569" mass="64268" checksum="8C808D138B6DD9A0" modified="2012-07-11" version="1">MLQIKDLSISFDGFEVLRKVNLDLAAGETLALTGANGTGKTSLLRAVAGEITPLEGEILLQKDIAPFFVHQECDTFSGTVKEYLFGAKPEISRIYTELCRSSDPIVYAELINAFNDAGGFELEASISSTINKFGIGIDDLDFPYRNLSHGFKRILSVIRGALSGSKLLLLDEPTNHLDIEMTLKLEEIVSSLSESGVGIIVVSHDRTFIDRVAHKTVYLKRGIAISISGGYSEMLAFLEKDFLSRKKKCVEIDKKIRQLELDVARRKSWSDSREASKRLSSDKGHEGHMAAKLAKRALVVRKRKERLVQQLEQEKPFVEKPITIKIPQYEVPNRKMLNAERISFSYGKKNIFRELSLNVDTNERIGLIGPNGSGKTTLMRCLVGILKPVNGRIYRNDSVDWVFIPQDMTRHFKKKTPFEEISDVGLDEQTTRSHLANIGFRGDRALANAELISCGERMRLAILKAILSRVEFIFMDEPTNHLDIESLEMLDKLLNDFPGGFLFISHDRQFIAEHGEKIFTIEDDGLKSLDYTKDIDIDSFTETKRNLTDSYEQSITRRKSGDSWSEFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B3</accession>
    <name>I2F7B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2183"/>
    <dbReference type="EnsemblBacteria" id="AFK07816">
        <property type="protein sequence ID" value="AFK07816"/>
        <property type="gene ID" value="Theba_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2183"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_2_1_0"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="395" mass="44033" checksum="4D5B1CCD55ED3ED6" modified="2012-07-11" version="1" precursor="true">MKTMTELMESNIKKNYVFSFLMNFRLSNGLWMIYMASRGMSLTQIGFLEGIFHVTSLMMEVPTGSVADLFGRKLSRSIGRCLSLVSILVLIGATSFFHFTIFMVLAALSYNLESGSGEALVYDSLKYLKAENNFISVLGRQEAIFQVSSVVALLIGGFLGTYSYHYAFWASSGIIAFSVVYSLSFTEPPILESVGRNSKTFRGFLKQIVDSFSLIARDRKVAFLIFFVQTILAFSACIFFYIQNYWKGLGRTEFQIGIYLAAGSFLAGLVAMKVQRLSHLLKEKKVLIILPLISVASMWGVALCSNKLPFFMVVAMIEAMLFVAGNDYINKLIPSRSRATIISFASMMYSLVMIIFFPIFGRIADTISFGVAFVSLAVMASCLYVLSMYLLKKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H1</accession>
    <name>I2F7H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731633.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2245"/>
    <dbReference type="EnsemblBacteria" id="AFK07874">
        <property type="protein sequence ID" value="AFK07874"/>
        <property type="gene ID" value="Theba_2245"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2245"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_9_0_0"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="169"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="351" mass="38072" checksum="93DA6C3895FC0FEC" modified="2012-07-11" version="1">MPRMLVATAPRKAAIVEYQDRKVAANEVMVEVEFASPKHGSEVADFRGESPLIDEFYDKDWHLILPRSAGEKKGVEFGSWNLGNMWVGKIVVKGVDVKDYSIGERVCSYGGIRETHIINAIGNDRLLKVPTGVSWKSAVCYDPAQFALSGIRDGNVRPGDYIAVIGLGAIGLMAVQLGKKIGARPVIGVDPIAIRREAALNSGADYVLDPGECDVGLEIKRLTGKLGADCIIETSGSAGALQSALRGLAYGGTVSYVAWAREFAGGINFGREAHYNYGRVVFSRAASEPNPDFPRWDRKRIEKTCWNLILDGSLSGDDIVNPVVNFEESPSAYCKYVDTNPELSIKLGVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7J6</accession>
    <name>I2F7J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2270"/>
    <dbReference type="EnsemblBacteria" id="AFK07899">
        <property type="protein sequence ID" value="AFK07899"/>
        <property type="gene ID" value="Theba_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2270"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254712_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="25564" checksum="5F9C886F9738FDAB" modified="2012-07-11" version="1" precursor="true">MENSDRKTMRHERRRQFFIKAAQELMKEGDESKLTAKSIAERAGYSASSLYDYFESLDKLLVMSVDEFMAEIGDMTEVEIEKCDRVTDCVEAAYLIFAEYFLDNPLLFRTIFLAPGSSRAKFFSNPELMPKFCEMGMKRLESLRQFDESLGLKKGSSLIIEQILTPEMFGILFMYFQGLYEVSKEEAIQMLKRNIDHVLEPFRELEEKTISSKERLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q8</accession>
    <name>I2F7Q8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731711.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07961">
        <property type="protein sequence ID" value="AFK07961"/>
        <property type="gene ID" value="Theba_2336"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2336"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_0"/>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="454" mass="49461" checksum="1CA9735478FA1DAE" modified="2012-07-11" version="1" precursor="true">MAKDIHKMLGEEKIGRLLLSLSLPATIGMLVQAMYNFVDTIFVGKGVGSMGIAGISIALPVQIFVMAFAQMFGIGGASVISRALGERDHEKARRAAGNVMVFSLAFGLVMTLLGQFFLDQLLIMLGASEAIIPYAREYLGIILLGSAFFSFGMAMNHVVRAEGKPKIAMAAMLISAVLNIILDPIFIFSLNMGIRGAALATVLSQAATSIYVLFYFLSGRSLLRVSLRSLIPEWRIMRETVSVGLSAFSRQVAGSVLAVVLNNSLVFYGGDIAVAVYGVINRLLMVFIMPMFGVNQGFLPIVGYNYGARKMRRARESVKLASAVTTMIALFSSIVMFLFARQLISIFTDETELIESTIYALRIVILATPTIGVQVIASGMFQALGKALPALFLSLLRQIIILIPLILVIPRFLGINGIWISFPLADLIAFAISLVFYLRELKIFRSGELNVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T2</accession>
    <name>I2F7T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731732.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07985">
        <property type="protein sequence ID" value="AFK07985"/>
        <property type="gene ID" value="Theba_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2364"/>
    <dbReference type="HOGENOM" id="CLU_1155351_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="240" mass="27331" checksum="49FF445F37F22C82" modified="2012-07-11" version="1" precursor="true">MKKIAVLSILMLILGVVATASPGFRNDMDGEILELRLQIQIANAINAANLSPEQLGQVYDLAKSTRDELEALKERVTNTLEETLEKAISGEEATFPEIDSTRTRMQSIVENYLSGLKSVITVEQAENLAEYFRERPLANRSEVHEKNAPIIGRIEERLPEIEEQMRQQFRNLPPEAQERLKNLDVDERTRVMKEKMTDRLNASRPGIVERPVQNKFTTQRLAMVLLSDEALEVMEKMLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W1</accession>
    <name>I2F7W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus retraction protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731756.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2396"/>
    <dbReference type="EnsemblBacteria" id="AFK08014">
        <property type="protein sequence ID" value="AFK08014"/>
        <property type="gene ID" value="Theba_2396"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2396"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_0"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="349" mass="39565" checksum="557DEAEF1D8A2A7F" modified="2012-07-11" version="1">MLIKEILSKGEQMNASDIHLTSGENVIYRVDGELIQDKLLTDEIMMKKITTELQEISEIKLQDSESKEIDFSFGFSSLRVRGNYFYSNKLPVVALRLIPKTIKTLEDLGYPPLFKEFCKPDKGLVLVAGPTGSGKSTTLAAMLENINRTRHVHLITIEDPVEYVFEPKNALIHQRELGSDTKSFYNGLKYALRQDPDVILVGEMRDSETMELAMTAAETGHLVFSTIHTNSAATTPERIVGVFPPHQQNQVAMQLANTLLAVIYQRLLRRRDGKGRIAVIEIMVVNQAIRNLIREQKFHQIESMMQAGIKYGMVTFDDALMDVFKKGIIDKDQLQDYARDPNAMLRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W6</accession>
    <name>I2F7W6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">Theba_2402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731761.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2402"/>
    <dbReference type="EnsemblBacteria" id="AFK08019">
        <property type="protein sequence ID" value="AFK08019"/>
        <property type="gene ID" value="Theba_2402"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2402"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_0"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK08019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="45538" checksum="5CE42F6E98E5E469" modified="2012-07-11" version="1" precursor="true">MSQLVVMGNTSLKGEIKASGSKNSVLPILAATVMIEEPVVIKNVPELRDVQTMISILQQIGKTVSFENETVTVMPGEILVGNVPYELVKKMRASFNIIGPLTMICGWAKVGKPGGCNIGQRPVDFHLKGLEAFGFRITEEHGDVMAVIPNSFEKEIVYALPFPSVGATEQLMTTAALMEGSTITIENAAREPEISDLQNFLNACGAQIAGASTPTIKITGVRNLHGSEYSVIPDRIETGTYLLGTIATKGDVKIHGTRSDHLISLLSILEEMGAGIEKGQDYLHAFWKGPLKPVRISSEPYPGFPTDLQPIITAVLATVEGTSVIEENVFENRFGYVDELNRMGARIKVSSSHANICGVDKLSGAEVVAPDIRAGAALVIAGLAADGETIINNVTHLFRGYERFQEKLRTLGAKITFYPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7W8</accession>
    <name>I2F7W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731763.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2404"/>
    <dbReference type="EnsemblBacteria" id="AFK08021">
        <property type="protein sequence ID" value="AFK08021"/>
        <property type="gene ID" value="Theba_2404"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2404"/>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2082018_0_0_0"/>
    <dbReference type="OrthoDB" id="2057660at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="117" mass="13267" checksum="47BC0A683AC1270C" modified="2012-07-11" version="1" precursor="true">MIFTISFFLWITFFGRFTLASVVSGVLVSVLPQYISSRLIRSGPVFATAFKIILALPIAVFQAFRLIFSRPVFTVRSEKSPENRIVEFGKIISITMTPEEIVISKDREGLLIHEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Y7</accession>
    <name>I2F7Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731778.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK08040">
        <property type="protein sequence ID" value="AFK08040"/>
        <property type="gene ID" value="Theba_2425"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_0_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="330" mass="34200" checksum="37CA1541C7E9EDD2" modified="2012-07-11" version="1" precursor="true">MLKTDTGRGRVSKHSEILSLGAILVILVLLFSLALPGKFLRPSNLQSMAFQLPELGVLAFAMMITMLTGGINLSIISSANLSGIIMAMILTGDLASGPGGAGLGWTIFLAVLAGLSISLLVGLVNGMIIAYIGVSPILATLGTMTFLEGISLVITRGYVISGLPRELLVIGNGTFLGVPVPMFILVAVAVGVAIILNKTRLGLSTYMIGSNIKATGFSGINTNKVTILVYMISGLLAGIASLIMIARFNSAKAGYGSSYLLVTVLVSVLGGINPNGGFGKVSGVFLGLILLQVISSGLNLLGISQFLTLALWGALLLGVEALRLTRRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z0</accession>
    <name>I2F7Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2428"/>
    <dbReference type="EnsemblBacteria" id="AFK08043">
        <property type="protein sequence ID" value="AFK08043"/>
        <property type="gene ID" value="Theba_2428"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2428"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658431" evidence="1">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="334" mass="35895" checksum="A93A3FF939EFA8F9" modified="2012-07-11" version="1" precursor="true">MNKKLLMLLFCVLFTVAVLAANYEIAVVVKIGGIPWFNRMEVGVKDAADELGVNAYQIGPSDADPAQQVKIVEDLIAKGVDAICVVPNDAKALEPVFEKARANGIIIITHESPEQKGGDWDVETIDNVKFGEANFEKLAQLMGGEGEFAVFVGGLTVPLHNFWADVGLAYVAEKYPNMKLVTERIPCGESVELSYQKTLELLNAYPNLKGIVGFGSLGPIGASQALNARNMKGKVQIVGTVIPSHADPYLKQGLMQWGYLWDPRDAGFAQVYLAKTLLDAKAALAEAGIPEGIVPAVVDGFEIPDLGKATLEGNIVKFDAQVDITAENALSYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F850</accession>
    <name>I2F850_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731835.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2494"/>
    <dbReference type="EnsemblBacteria" id="AFK08103">
        <property type="protein sequence ID" value="AFK08103"/>
        <property type="gene ID" value="Theba_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2494"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068947_0_0_0"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="58"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="262" mass="29710" checksum="69CC9EDE15824163" modified="2012-07-11" version="1">MENLRMHGDPPFRVVVAHGGPGAAGGVAPLARELGKKRGIVEPYQTKKTVSGQIEELRETVEKYCSPPVILLGHSWGAWLVFLFAAKYSDLVNRIILISSGPFEQHYASGIMNTRLNRLGAKEKARVEELMSLLSNAELKDREMLSEFRKLMAKTDHFDLLEDAERVEVNIDAEIYKSVWTEASEMRSSGELLESGKKIRCPVLAVHGDFDPNPAEGVEIPLSRIIKDFKFRLLERCGHMPWMEKHAREEFYRIVEAEFEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F860</accession>
    <name>I2F860_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731845.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2505"/>
    <dbReference type="EnsemblBacteria" id="AFK08113">
        <property type="protein sequence ID" value="AFK08113"/>
        <property type="gene ID" value="Theba_2505"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2505"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="675" mass="74096" checksum="65536C7FDF401283" modified="2012-07-11" version="1" precursor="true">MRNRIILIAALLICALSFAGLKDISASPYSAAIEKLFAAGIVEAEDDLFSPTEALSRADAAEWIVKTFKLSTIQSMKLEEEVEKKFVYTDPLGVIDEAFVVPSAKDIIDIEGEEYIEGLIKVRAEDVVDGLYRPFEAVTGAEFALAVAKVLFGVDEPIDYSAKLSQLVYVPSQLLSLERPLRREEAAQILSNFVDNPDFKIITMLATADIHGHIEPYLPSGAKYPVGAMERMAYYVKTERAIQPNLLLLDVGDAPYNTNVANLFEGEPVIKIMNMMGYDAMVLGNHDFDFPFNVMERNSKLANFPFLGANTLYLGESPYFLEPYIIKEVDGIKIAIVGLTDDSSAWYTHPRNVAGITFEEQYSAAKRLLDEVSPQADLVVALAHLHGGNRVLPAKVPGYDLIFEGGRDVVAFPEKINGSWVISSGKHAELISKTNLNIYNGELIGINFAHVFMSQNLPQDEEVVEVVQSYVSQLDEKLGTVIGKTEVDLDGERGTVRLKESNLANAIADSLREMTGTDFAIQNGGGVRASIPAGDITIKDVYTVLPFDNLVVAVRATGKQIWDVLEHGISAYPAAAGQFLQVSGLEYTFDASKPPYERLISVTSNGVPLDPDKMYTLTANDFLTGGGDKFTMFLGMEKVIETKSFLRDAFAEYIERHGTIAPVNEGRITIINPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F868</accession>
    <name>I2F868_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">Theba_2513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2513"/>
    <dbReference type="EnsemblBacteria" id="AFK08121">
        <property type="protein sequence ID" value="AFK08121"/>
        <property type="gene ID" value="Theba_2513"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2513"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="183" mass="21045" checksum="D1D8B0155D251A7C" modified="2012-07-11" version="1">MMTCEVLLLGNPLLRETSSPVSDFRSQETIGQIVMLKQALDEFRKENGFGRGISAPQIGILKRIVALNLGQGSFVIANPRIVDRSRATFTMWDDCMSFPHLLIRLERSLSVDVVYEDERGIEYEWKGVDQARSELLQHEIDHLDGILAIDHALDAKSIIYRSEYERNREYYDHLVDYSIEPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F875</accession>
    <name>I2F875_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489559.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08128">
        <property type="protein sequence ID" value="AFK08128"/>
        <property type="gene ID" value="Theba_2523"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2523"/>
    <dbReference type="HOGENOM" id="CLU_3137545_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="49" mass="5656" checksum="C71D69D57DCE9914" modified="2012-07-11" version="1" precursor="true">MKRLITLLAFVLFATAAVIALEKSPDYYTSQKETKSIMEFTIHSMMKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D5</accession>
    <name>I2F8D5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <shortName evidence="4">Xylulokinase</shortName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylB</name>
        <name evidence="7" type="ORF">Theba_2588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731904.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2588"/>
    <dbReference type="EnsemblBacteria" id="AFK08188">
        <property type="protein sequence ID" value="AFK08188"/>
        <property type="gene ID" value="Theba_2588"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2588"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="256"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="509" mass="56467" checksum="AC19E47C5EF89889" modified="2012-07-11" version="1">MKYVIAYDLGTTGNKATLYGIDGKLLASSFSGYKTYHPGPNQVEQDPLEWWESVKNTTPDLIARAGVNPEEIVAISFSGQMMGAIPVDRDGKLLRRAIIWADQRSVEQSARLEEVGNDFVYRLTGSRITPTYSGPKIAWIKDNEPEIYNKAHKFLNAKDYIVSRFTGEFGTDHSDASMTLLFDIENLKWSEKLVEVFGLDMEKLPNVTSSTNVVSEILPKVAEELGLSKKTLIVRGGGDGACACLGAGVVSPDEAYLYLGSSSWVSTCSTEPIFDEKSRTFNFAYPIEGFYCPTGTMQAGGASYQWAKDALCQHEEEKAKALGLSAFTIMDDLVDQTRPGAGNLIFLPYLLGERSPRWNINARGAFIGLSSTHRKADMLRAVLEGVVFNLKIVLDILETKGKFDKIRLIGGGAKGRNWKQIVADIFGKTVTIPEYLEEATSMGAAIIGAVGAGEMTFKEASTFVRDVQFIKYNPENHRYYERLFEVFDRAYSSLIETYEDLAKLRTYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8D9</accession>
    <name>I2F8D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar phosphate isomerase involved in capsule formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. PHI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731908.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2592"/>
    <dbReference type="EnsemblBacteria" id="AFK08192">
        <property type="protein sequence ID" value="AFK08192"/>
        <property type="gene ID" value="Theba_2592"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2592"/>
    <dbReference type="eggNOG" id="COG0794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094236_1_1_0"/>
    <dbReference type="OrthoDB" id="1425559at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05005">
        <property type="entry name" value="SIS_PHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017552">
        <property type="entry name" value="PHI/rmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43443">
        <property type="entry name" value="PTHR43443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03127">
        <property type="entry name" value="RuMP_HxlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="186" mass="19885" checksum="3C72932381BD3565" modified="2012-07-11" version="1">MKFEGTLDLVIDEIRSVLSGVTDESIEELSESILNARRVFLFAMGRSGLAIKAFAMRLMHLGLKVHVVGEVTSPSLGEGDLLIIGSASGETPSVVLNSKKARKFGAGIASITASKESTVAGISDIVITIPTKTPKVPDRAGVSSVQPMGNLFEQSLLILTDIVVMNLMERLSIDSETMFKNHANLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E6</accession>
    <name>I2F8E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489422.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2599"/>
    <dbReference type="EnsemblBacteria" id="AFK08199">
        <property type="protein sequence ID" value="AFK08199"/>
        <property type="gene ID" value="Theba_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2599"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="151"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="363" mass="40612" checksum="C55D60409B538B55" modified="2012-07-11" version="1" precursor="true">MQSTKSRIAKNFFKHKLGVVGLIALSIMYLLVIFSDFIAPYNYVTSHRNFVYAPPSKIRFFDEEGKWIGPFVYGMKKVRNPVTYRLEFSEDTSRPVPVKFFVRGEEYRFWGIFKTDLHLFGVEESSDIAMVLLFGGDRFGRDLFSRVLIGGKVSMTVGLVGTLISVFIGAIVGALSGFYGGTIDVVIQRFIELLRSFPRIPLWLALATILPPQWPSTWVYFGIVIVLSLIGWMGVARVVRGMVLSLREKEFILAARVSGVSNMKIITRHLIPNTISYLIVVSTLSIPGMILGESAISFLGLGIKEPMTSWGLLLKQAQSISELEAHPWLMVPGIFIIVAVLSFNFVGDALRDAVDPYRAVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F8</accession>
    <name>I2F8F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489406.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2611"/>
    <dbReference type="EnsemblBacteria" id="AFK08211">
        <property type="protein sequence ID" value="AFK08211"/>
        <property type="gene ID" value="Theba_2611"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2611"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="33571" checksum="8E40F1D991883F8D" modified="2012-07-11" version="1">MQIKLRYLLVFILPALILYSIFIIYPLFDSLILSFFSWSGVGPRTFVGLKNFQTLFSGSFSKELFNAFFHNVYFFIMLTILELGLGFLIALMLASKIKGAGVFRVVTYIPNMIPLVLVGFMWVLFLNPQAGLVNQLLRTVGLGSLAQPWLGQANTALTTIILVNVWRNLGFYVLVILAAILDISPELIEAAYIDGANNWRITWRIIFPLAFSTFRTLAILLFIWSFNIFDMVYALEGVQAGPYRSTDVLGTLFYRTAFGGLGSGAVDMGLGASVTVFIFAIVMPVSILYVFIVEKRQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H2</accession>
    <name>I2F8H2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2625"/>
    <dbReference type="EnsemblBacteria" id="AFK08225">
        <property type="protein sequence ID" value="AFK08225"/>
        <property type="gene ID" value="Theba_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2625"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760327_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="364" mass="40113" checksum="D570D609535C9A26" modified="2012-07-11" version="1">MEKKFEFDSAGIEILKISSASADLQIDLVEDGNVIAYVEVDSNDYVPEAESSGKRLSIKFQKGTNINIPFIKNLFDGGAEVKSVRLLVPKSVRELDANSASGDIVITDFDLRSLKISNVSGDVKIENCSVENLNFSTVSGDLNFIASNYRRGKFGSVSGDLSIKGLPPMERETIVSSVSGDAIVSYSGEPKFDATISSVSGDISSDVGLVKIDKKHYRSGNGESQEYLKMNSVSGDLIISTKYTGTPAKEVKVESRTVSSEEKRGHRSAVVEENLQDQETRKILLLFKEGKLTKEYTFEMLGILGYSEQEIEEMLEVDEELQKFKDSVDVVIKNEDVESEKSFEAIEKPETPEKPDTPEEPKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8K8</accession>
    <name>I2F8K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type metal ion transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2662"/>
    <dbReference type="EnsemblBacteria" id="AFK08261">
        <property type="protein sequence ID" value="AFK08261"/>
        <property type="gene ID" value="Theba_2662"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2662"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="210" mass="22822" checksum="89039E22C8DAA405" modified="2012-07-11" version="1">MLSQIFNATLETLYMLLLSGFLATFLGIPLGVGLYLCSRSRGLKGLYALLDLLVNIFRSIPFIILVLLLIPVTKRVMGTIIGPNAAIFNLTIAAIPFMARLSENSFNGVPSGIIDSSNSMGLNRWQMVTRVLIPETLPDQIGNVTVLLINLVTYTAIAGAVGAGGLGQLAINYGYYRFQWDVVLYAVIVLVAISQLLQFTGGKLAKRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M0</accession>
    <name>I2F8M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">Theba_2674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731969.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2674"/>
    <dbReference type="EnsemblBacteria" id="AFK08273">
        <property type="protein sequence ID" value="AFK08273"/>
        <property type="gene ID" value="Theba_2674"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2674"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_1_0"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="17191" checksum="812886EA89CF47FB" modified="2012-07-11" version="1">MKTVVTNKKARFQYHLMDSYEAGIELVGTEVKSLRLGGASLIDAYCKIESGEIFLVDCNISLYTHGNVWNHEPRRKRRLLMHRKEILRLDQKTKEKGLTIIPLKIYFNDKGKAKVEICLAKGKRLFDKREDIAKRDVERRMRQQADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S2</accession>
    <name>I2F8S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732018.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08325">
        <property type="protein sequence ID" value="AFK08325"/>
        <property type="gene ID" value="Theba_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2731"/>
    <dbReference type="HOGENOM" id="CLU_846792_0_0_0"/>
    <dbReference type="OrthoDB" id="2092401at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658744" evidence="1">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="38322" checksum="9B42896A5BC6899E" modified="2012-07-11" version="1" precursor="true">MKKFTILLLLVLSVSSIALAQRLLPQDSARFISIVTEGTFNNFPDNLIGESFEAFFEMPRWKYSKEGTENIVEFSGNYLDENGEAATVKMRFSVKEEDSTFIMNYWEINGVPQDNSNQFAFLEKIFLPERADVAISIVKDGYFYDYPEKIIGESFSNYFSDGSWDYFVTADNQDVVEYIGFLYEEDETVETVFQFTVNLDERTFDIEYLGIDDVSQDDAAIDSLLASIMDSKITEVKNSYFDVYYNWMTLGEAFDGFFYEPHWDYFVSTDDLHIVEFYGTFDLGGIPAEVYAQFEVYEDGTFDLYYWEIDEQYETINAFYLLLELIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E0HXB9</accession>
    <name>E0HXB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2168</name>
        <name evidence="2" type="ORF">Theba_2169</name>
        <name evidence="3" type="ORF">Theba_2170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2168"/>
    <dbReference type="EnsemblBacteria" id="AFK07801">
        <property type="protein sequence ID" value="AFK07801"/>
        <property type="gene ID" value="Theba_2168"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07802">
        <property type="protein sequence ID" value="AFK07802"/>
        <property type="gene ID" value="Theba_2169"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07803">
        <property type="protein sequence ID" value="AFK07803"/>
        <property type="gene ID" value="Theba_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2168"/>
    <dbReference type="KEGG" id="mpg:Theba_2169"/>
    <dbReference type="KEGG" id="mpg:Theba_2170"/>
    <dbReference type="HOGENOM" id="CLU_3154688_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="48" mass="5072" checksum="170F9E1C2F0824C0" modified="2010-11-02" version="1" precursor="true">MKKMIAILLIGLVSFGTVALAGPGLWKIPEGEFTVDGGPGLWKIPEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1F9</accession>
    <name>I2F1F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large extracellular alpha-helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0007"/>
    <dbReference type="EnsemblBacteria" id="AFK05762">
        <property type="protein sequence ID" value="AFK05762"/>
        <property type="gene ID" value="Theba_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0007"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249027_0_0_0"/>
    <dbReference type="OrthoDB" id="231654at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A2M" evidence="2">
        <location>
            <begin position="752"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1493" mass="166809" checksum="9507E64CAE656530" modified="2012-07-11" version="1" precursor="true">MRKVCVLLLILLLAGLTAIAFEIQRYGYDLSSSFVEFYSLDYLPSVYTDDKDSFIDIKIYDLDEEDLTGAITIGDVRVSGDPLYASRQTVKEKQRIYLPREELMGLRLIVVSSQSGTAKLMTSFRMVGAQLLAHEDGAMLRLWKKDDGSFLDHFSLYRLSDGELLGQSEEGVFVFDYLPKTEEAILVQSSEGSILWRPGEYDYYFSSRHISLTFTDRPAYKAGEVVNFRSFIREVTPSGYKIPEIDFVEIEIVDPLNRGVYAQTLEPDDLGSVVGSFRTYSEITRGSYRIIVRWGENEDYYYFQIADYKKPTFFTLAEPTTSAFRKGEPVTIDVSSEYYFGDPVSLGKVDYTIYKGTQYIDNGSARLDGSGKTVIGYTGELESGAYYAIVTVSDDTGMQSRSVVDFKIVQGSFDFLVDYRFTENEALVRIETRLNDDTPVSKEFEIKAWYEESVILMDKGEHVEKNLKINVFKGELSTDSGGKADVSIDLRQVPPDTVVYFEINGSPSGEPEIVNTYSVYTGGYYDYYGSILIDSVKSAEPGSSAEVVFYTPSPMDLWIISDFSGEFSQFPFSSTEGKNTVYIEVPEGYAYDNFMLFIVGYRDYQIIQSSLIEVQTSSRELSIETLTQERYSPGDTVNMKIQVTDSEGKPAEVGLTVSVVSQAMLSIFEGDYDQWKGSLGSPFNRGFNTISINDLYYSAYPSIAKLGDLLESQPPAAESKVTGGAPLGMGDLGGDEKSLTSDVRARKLFSDSAFWSTGTFTDENGQAELSFVVPEDLDTWTVRTLSSSANGDFSYSKSSFETWKPMTVSSFLPEFLIAGDTVNLVFSVKNNLDSTLPVITGFYLGEEVIEEKGSSIKAFESRSFSYEVNVQDLLSSEKDQKLKVKFVVKGSHGSDGVEYEIPIKPRFSYSRFGSLDFLEGNKTLEFSENSAGTITISSTIDPILLEAVRYLVDYPYGCVEQTMSRLLPALAASQLLEEADTAFINKVSRVVSEGLERLYGYQHYDGGWGWWKDDNSTPFMTAYVMLGLYLATENGYVINKDVVSMGYSEMKTLYKEDPDPFLQYVIVLFSRKLRDPVGSVVDFKGDVPSIILTSLAYEALNMDDKAEDLIEEAMEYVDLDADDVISGTSFDYFFDDIVTLSLLLKASVDLEMPSEDIFEISKRLLKMGNGSYWYRTSSTALAILSLSSVSSSLSENAQVEVSLIGGEVLYSGGLSESITIPFCEENIIVKSSEMVAVSVNGEKAVAAEEIEPENSGLIVKRVLRRKLAVPMDDTHVLTTPQIDSPYVVSSIKTLSPDEVGSLEINVSKTVENMQISIKDGELFLGEYGLGLKVYEGDVLGISNGEIIIRAFEESYYDEPTVEIYSVRLGTPGSLTAGETIVSEVHIKIPEDVPYVVVEDMLPATGISVEENLEADVLGYTKFYYFDYYWWGYTFKDARYDRIAFFFREGGEFVTKNSWRILTSGEFIIPPVQAWAMYDSNYRANTESIVLVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1G2</accession>
    <name>I2F1G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux protein, MATE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0010"/>
    <dbReference type="EnsemblBacteria" id="AFK05765">
        <property type="protein sequence ID" value="AFK05765"/>
        <property type="gene ID" value="Theba_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0010"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="454" mass="49176" checksum="A8D9CB124D4108CC" modified="2012-07-11" version="1">MARDLTQGNILKNLLVMSVPTMIGFSAQMVYDIVDIFWIGRISGEAIAGVTIFTTLFWIVDILNSIIGQSSVSLISQSFGKKDLEGTNRAIEQTITFKFIVALISALLVAAFLKPSLGFFSNDPTVITAALDYGYIRLFFLPMMFSSYSVNTALRCIGDAKSPMYIMMMASALNVVLDPILMFSHIPGTSIPGFGLGVFGAAVATVIAQTASFLLGFFILFSGKEGVKPKLSRLFRLDRHIDRKLLTIGLPTGLEGFFRNLAAVVVLKFVALYGTTAVAAVGVTGRLFGLAFMPLVGLNMGGSAMVGQNLGADDVGRARATAKTAGLIGFFIMFFFALIAFFGGEIVIGIFNDDPEIISYGASFLKYGSLGISVLAYGFGLSSVFGGSGYNFPFVVGSVVSRWLIQVPMLIVFVAFMKASIVWVWLSYVFSDIAEATVMIFYYLRGKWETRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I0</accession>
    <name>I2F1I0_9BACT</name>
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        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
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        </alternativeName>
    </protein>
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        <name evidence="3" type="primary">tmk</name>
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    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0029"/>
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        <property type="protein sequence ID" value="AFK05783"/>
        <property type="gene ID" value="Theba_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0029"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_0"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
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            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK05783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="209" mass="24136" checksum="034790ED6CAEC7B2" modified="2012-07-11" version="1">MFISVEGIDGCGKTTQIKLLAEYLSQLDVEFIIVREPGGTKAGEEIRDILLHKEYHLFSESELLLFMAARAQIVREVIRPELEKGKTVIADRFMDSSVAYQGVGRRLGREIVQAMNAFAVGGTVPDITFYIDVPTDVAISRMRKEKKNDKIEMENFDFFERVREGYEKLMVENRERFVRIDGKQSEEKVQTDIRKSLRVLFHKKNQNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1J5</accession>
    <name>I2F1J5_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Putative permease, DMT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0046"/>
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        <property type="gene ID" value="Theba_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0046"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1515911at2"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
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            <end position="252"/>
        </location>
    </feature>
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        <location>
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            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="146"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="297" mass="31874" checksum="E227E97EDA9204F3" modified="2012-07-11" version="1" precursor="true">MNRSKEKSSGTKSVILLILTGLLWSTGGLLIKNVDSNPLAISGIRSMIASLVILVALGRPKFTWSLPQIASALSYSATVILFVSANKMTTAANAILLQSTAPIYVALLSVWILKERAKLLDWITIIAVFGGMALFFFESLDSRGMAGNILAVASGVTFALFNIFMRLQKDGSPLESVLLGNILTAAIGVPFIVGSLPSPSGWISLFILGVAQLGLSYVFYSEAIKHSTALEAILILMIEPILSPVWVFLFMGEIPGRLPMIGGAVVIGAIAIRFVLRNLAGRPIFGVPRRSRRRNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1S8</accession>
    <name>I2F1S8_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0135"/>
    <dbReference type="EnsemblBacteria" id="AFK05881">
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        <property type="gene ID" value="Theba_0135"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3272600_0_0_0"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="41" mass="4558" checksum="AA4900C1C96B5632" modified="2012-07-11" version="1">MSKKSKPAKPKPNSSVLPPKPIFEGGHQKKDSGEKVEERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1U2</accession>
    <name>I2F1U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730060.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0153"/>
    <dbReference type="EnsemblBacteria" id="AFK05895">
        <property type="protein sequence ID" value="AFK05895"/>
        <property type="gene ID" value="Theba_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0153"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_4_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="279"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="485" mass="53876" checksum="C8BD5BB4F9ABB74C" modified="2012-07-11" version="1">MNVFLGIDIGTTNIKCLVLGEDGRILEVIHSLTPKNKERGVEFLDLELTRSYVESIIGKVGALHSLAAIAFSSFGETVIPVRQRKALSKPVMWYDRSTYPLWESHRESVDNLAPYRITGVENSYTFSLYKILLQKELFRPEGVENWLPVSSYLAYSLGGVPAWDMSQACRSFMVNIHSRRWNSQLIKYIGESEETMGELRYTGEPVGHTKSGIPLISAGHDHITGLYAARAFARGKEFLFDSMGSASVIAAVVSGTAESLDFAGPFMPGGTVGIAYEDHQYYIESNVRYYGKLLQSLMDLTQTDATKEGYERLNNEIEKLGQLNSRPLFLVNGDLVVGEGLQGITLLEMPIPLNKEQLMQSAYIYLSSISKRIVDNIEKITRKELPIISGGGGSLNSLLMKYKASLLGKEIWVLPTSELTALGGAFAAAHGVGADEVIEKCVNLLEPEEIHPDEHLVEPLKEIYEKNAKEYLAIERNKKLDIQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V4</accession>
    <name>I2F1V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Theba_0167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730071.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0167"/>
    <dbReference type="EnsemblBacteria" id="AFK05907">
        <property type="protein sequence ID" value="AFK05907"/>
        <property type="gene ID" value="Theba_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0167"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_0"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK05907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="37236" checksum="9BB83EC2C81A529A" modified="2012-07-11" version="1">MRGVIETYEKYLPVTQKTPRVSLLEGDTPLIHLEKASKKFGLNVYAKYEGANPTGSFKDRGMVLAIAKAIEEGSKAVICASTGNTSASAAAYSARTGLKSIILIPEGKIALGKLAQAMIYGAKVIQIDGNFDECLELAKSISENYPVTLVNSLNPYRLEGQKTAAFEIVDVLGRAPDYHFIPVGNAGNITAYWMGYREYHESGLSDGLPKMMGFQAEGAAPIVYDRVFDNPETIATAIRIGNPASWKKAVAARDESEGVIEALTDEEILEAQRLLAASEGVFCEPASAASFGGFLRKAEEGLFCSSDLVVCTLTGNGLKDPDAVLKSVDKPIVVENSLDAVLKEAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1V6</accession>
    <name>I2F1V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730073.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0169"/>
    <dbReference type="EnsemblBacteria" id="AFK05909">
        <property type="protein sequence ID" value="AFK05909"/>
        <property type="gene ID" value="Theba_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0169"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_0"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="475" mass="53412" checksum="81C137B1CC951AD6" modified="2012-07-11" version="1">MSGIAVFYGGTREMAKSSLSLLGHRGSRTTVLETGQKIGMGAVVSRAFDSKMSIFEGDGEYVVFDGFLRNHPDTAWPEKIMKLYKESGRGFLKELDGSFAFAIYTDKETLIARDPLGLKPLYYGYINGYIVCTSEMKALAPFCNEVKIFPPGHYYSSLVGFERYSSLEDLLTEEPVMRNEYEATELLRTSLGEAIENRISSINSDPIVFLSGGLDSSCIAAVASSLNGSLRTFTVGSGDGKDPKFAREVSEYLGTDHSEYTYDFKEMLRTLPEVIYHLESFDPPLVRSAIPNYIVAKMAAEEGSSFVFMGEGADELFAGYEYMKELPSSESIDEESLRITRNGYRSGFQRNDRMSLAFGIEFDVPFMDPSVVNLAFSIPVDWKIHGPEKTEKWILRKAFESELPKSVVWRKKSKFSVGSGSSHLMKEYAEEKISDSEFETERREKGIRSKEELLYYRIFDDLFPSGCAAKTVYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W0</accession>
    <name>I2F1W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730077.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0173"/>
    <dbReference type="EnsemblBacteria" id="AFK05913">
        <property type="protein sequence ID" value="AFK05913"/>
        <property type="gene ID" value="Theba_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0173"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629779_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="194"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="321"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK05913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="435" mass="50008" checksum="79D6ABC5176CFB31" modified="2012-07-11" version="1">MSRSSGFEEVSERTQSTRMKRSGGSTVDLVCKISSIVNNCSGRNELSERIQDSLLETLSYHDAKIFFSDEIIYYVDSSSQIVNHSYDYSPTEHLPACARDFLKSDKLLSIDSACKEHDCPLKSSKLENEHRFSFKLETEEKTYGVLCVNTLEHLAMDSEEFQLLKWISSEIAYALKRIEREDYLKTAKGELQKSKKSLRNLFNENLAVMIVLDPETRRFVNANDAALNFYGWDKETLLSKRIEDVNTLPAETLAEEMKKAFNREKIKFDFKHRLADVSVRDVEAFSKRVEIDGHDRILSIIHDVTDRKVAERKLQRTVGELKKITLTVINALEVTMNLRDPYTAGHQARVTALAMAIAERLSLDEERLDALRFASIIHDVGKIKVPSEILNKPGKLNRLEFAMIKEHPLVGRNLFTEVDFKVPISEIIYQHHERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W9</accession>
    <name>I2F1W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730086.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0182"/>
    <dbReference type="EnsemblBacteria" id="AFK05922">
        <property type="protein sequence ID" value="AFK05922"/>
        <property type="gene ID" value="Theba_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0182"/>
    <dbReference type="eggNOG" id="ENOG5030J0J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031634_0_0_0"/>
    <dbReference type="OrthoDB" id="1979475at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="556" mass="61835" checksum="9A45C46048BAF991" modified="2012-07-11" version="1">MRPKMVISLTSTLINAHYNIPRSLYHFKKRERLWEPALIIGVVLLMVFSLGPLYMSLLNTMYDQYEAAGMRQLFLAGPFLIANLFGLIMGVFLMISTFFFGDDMSVLIPLPLKSTEVLMSKFLVVLVDLMVISIAVILPAYILYGIRSGAGISYWIFMAIIFLLSQVLPIMLSAIIVLPLSRLFRFKRYRDSIVYLISALVVLGFLVFVSLTSRVDPNMSAEEFARIFSSEDAILNKTAGAYPPTILVTKALSKPFLEGLLWLLAFIGLHAAALGIFLFFGHKFYYSVYSSLQENFAKRSKLEEGEIAWLMGLQQTKFSALYKREWWYFLKVPAFAFNGFGNVLVFPILLVIAAVAGQTDQLGQMLDQFQQYKPVFVPVGALVAAVAGGINGLASSMFSREGDLIRELKVLPVDVNEIVKVKFLHIETLSLIGPAFGAVALSLILGLSFIEALVVFVVGGLTLTFLNILQMIIDSIKPILEWENPQRAMKQNVNVALSIPVVFGYVGGLGYLAFLLKDNISGTIMTIILTAIALVGIVVTWPILIKRANRLFARDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F208</accession>
    <name>I2F208_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730123.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05961">
        <property type="protein sequence ID" value="AFK05961"/>
        <property type="gene ID" value="Theba_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0227"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278203_0_0_0"/>
    <dbReference type="OrthoDB" id="1951820at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658248" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124729" checksum="FBE7CD27330A2B72" modified="2012-07-11" version="1" precursor="true">MKRLFLFSTAILLLAVFLSSCFQPQKKVEVIDLGIVEYTQEIIFLTQEDSGEYVFFIRSPDSFVEVDGEFIGKMTYWVDYDTKELVVNHTFESDWMLTELWLGYSLSVQGLDKNGDGELEKDDLDDHVIVNPKSANFTYRKSLESFIQEDTTVFYFGVHLFLEKEVEENVFSSKLFKYEHGVCKFHVTYFNENGQKDPWLNGFIDGDAKGSKSGEYDWILTKTASPTVVPNFPSSSGTEKQIEYILEAKRLPLKEGTTFSISGSAGVLNSGDATAKNVQVELQLQKSVGATWQDIGSPKMRSLGDIDPGYKSVPFSFSFSGNEGDYFRVSMKITSDNFPTTFVYETFLMPKPAEMQPLDANATVEDQPFPPTGFEVLNHSSAGWPWNIADTSLATKTYFVTIRSIEQLQAGEYWLTNMATLTESDTKDKRVDDAIVQIIVIGGSEDSGTLQATTTHEIVWNREIEYDWELEKRVLPDSVTLTQGASQTFVYTLSATRLETPVASGSDVHSLTGEVEVLFTSTGITTADNLKIHVQLESSINGSDWSTEGATVSVDTSSKNSFSSGEEHTYPFSIPGFTPIEGKFYRVTAYVKADGSLPTQDTSNHSGPHYPNITKKYDEEASVDDLLDNIEDEIGNLVTGFSITDIVNHPSWPTDISTNTKYVYSIRIENIEAAQGTYFLTNNATLTEKDTKEKKDDSQTVVIIVPDPSVETGSIDASVTHEVLWTNEIPYEWDLEKSVEPEHATLADGQTASFDYSLIVSRIEGQTTGTATYSITGIATATNVGDLPLTEVLLEVEFDGETKTLISASDSVSLNPGESVDRTFTFVRSSLSSPVSVTVIATGTAVTDYSDTDSSTSDIPESPTSTDYLNESAYLVDEFTNLNEFKLHGFTVVSTPLTWRVHIDSSNLDGNGEAAFHYPVDITNDSANFQNSPYSLHNIATLYKEDTGDAYYATDDATVTIYTPTEGGFRTQTQGGWGSSASGNNPGTYRDANFASTFPSGLVIGDATGYKAIFTTSASIENFLPAGGTSGSLDQNYTDPTATSAGTLAGQAVALTLSVGFDLYDPNFCTSSYNLKDLVIVTGIFKDWTVAEVLAEANRYLAGLGSSFTASELNDVLDAINQNYVDGTHDNGFLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F228</accession>
    <name>I2F228_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730141.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0247"/>
    <dbReference type="EnsemblBacteria" id="AFK05981">
        <property type="protein sequence ID" value="AFK05981"/>
        <property type="gene ID" value="Theba_0247"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0247"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_0"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="172"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="296" mass="31645" checksum="36BB1EEC8608B270" modified="2012-07-11" version="1">MNLFDAIGNTPLLELSSFGHSAKIFLKIEKNNPGGSIKDRTVLGMILDAERKGILKKGMTIVEPTSGNTGIAIAMLAAPRGYGAVLFMPESASIERVKIMEALGAEVVKTPSEKGISGSYDGAKTYLKNNTDSFMLDQFNNQSNPGYHYASTGPEIYSQVGEDTDAFICGMGTGGTVSGVGRFLKEKKPDVYIAGIEPEGSPFISKGRSGSHKIQGIGPGFKPQTLDLSLLDEVMTIEDEEALSVMKWLHKKEGLLVGISSGANVAGALQLSKKGFKRIATIAPDTYERYLSVDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F261</accession>
    <name>I2F261_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ORF">Theba_0282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730169.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0282"/>
    <dbReference type="EnsemblBacteria" id="AFK06014">
        <property type="protein sequence ID" value="AFK06014"/>
        <property type="gene ID" value="Theba_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0282"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_0"/>
    <dbReference type="OrthoDB" id="1279539at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="190" mass="21152" checksum="E35C8E5A70201784" modified="2012-07-11" version="1">MSGKLTVVVGPMYSGKTSTLLSMIEIYTLGKKRIKVFKPVIDDRYSSDHVVSHSGQMAEAINVYDSSEIKEIVSKEKGKLDAIFIDEINFFDENLLRIVEEIIFSGVDVFCVGLDLSYKHRPFAVTANLMAAADEVIKKKAVCHICGEYNATVTHRISGPTDSEIDIGGMEKYIAVCRDCYKKLNAKDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2B4</accession>
    <name>I2F2B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491912.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0338"/>
    <dbReference type="EnsemblBacteria" id="AFK06067">
        <property type="protein sequence ID" value="AFK06067"/>
        <property type="gene ID" value="Theba_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0338"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_0"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="270" mass="29294" checksum="1BA06646FB197685" modified="2012-07-11" version="1">MAKVYVVTSGKGGVGKTTITANIGCALANKGAKVCLIDADIGLKNLDITLGLENRVVHTILDVANGKVTASEALVRHKQIKGLYLLAASQIATKEMLSPEDMKKMVAELYPKFDYIIVDSPAGIERGFRNAIAAAEKALIVTTPELPAITDADRVIGLLENSGMQETNIRLLINRFKIQMVKRGDMLTREDIQGNLAIDLIGIIPDSDEVIIATNKGVPVILNGNGEGIGKVFENIALRMQGEPIPVEHDILEHGSKGFLEFLKRIFRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2F8</accession>
    <name>I2F2F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor EF-G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491972.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0383"/>
    <dbReference type="EnsemblBacteria" id="AFK06111">
        <property type="protein sequence ID" value="AFK06111"/>
        <property type="gene ID" value="Theba_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0383"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_0"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="690" mass="75871" checksum="073F57E061CA3870" modified="2012-07-11" version="1">MDKIPVDAKRDIVLIGHHGSGKTQIVDAMLFNAKLIDRIGILATDSEEVEKEKKASFSMGVTSLPHNDKRIYVIDTPGMSDFYAETANGIFASENVVAVINSTAGLEIQTERFGSIAKELKKGIIAFFNMLDKERAGYEETLSDLADTFERTPVLVQLPIGREADFRGIVDLVKMKAYIYENEGAFKEEDIPADLKSAAEESRTKMIEDIVQNDEELMMKYLEGEELSTEELITALRKAYLANEVIPVLLGSAGKNIGISQLLDFVSAVGKGPSEASPKAATLLSGEKIDVVPAEEEPLVAYIFKSVVDPFVGKLTFMKLLSGTLKQGDSFYVVDQDSSEKVGHVMLPEGTKEIEVDEATVGDIVKLSKLKKSAAGNTVAHKDRQLKLDLPVMPEPMISKSIQPKSKGDIDKISGGLARLAESDPTFKWENDPETNETVISGLGSVHLDIMIERLKKLFSVDVEVGKPKIAYRETVRKTVEAEYKHKKQTGGHGQYGHVQIKIEPNERGAGFEFIDKIVGGVVPKNYIPAVEKGIVEAMKKGVLASYPVVDAKVTLFYGSYHDVDSSDMSFQIAARQAFKNGMAEANPVILEPLMDVEVFVPEESTGDIMGEITSRRGRPMGMEPQGKGTSKVVAQVPLAEMLDFANKLSSITSGRGYFTMKFSGYQETPPDVQQKIILERQRELEEQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2G0</accession>
    <name>I2F2G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730234.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0385"/>
    <dbReference type="EnsemblBacteria" id="AFK06113">
        <property type="protein sequence ID" value="AFK06113"/>
        <property type="gene ID" value="Theba_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0385"/>
    <dbReference type="HOGENOM" id="CLU_675794_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="45496" checksum="434E5980F1A337A4" modified="2012-07-11" version="1" precursor="true">MKKILVSLMLVFLASISISQQLYIFSGFSIYSGEVVFENGTAIIELPYGADIVPESLSVFGAPERTHIRYLPADSLKSLYEKQIGRWIKFLFDDGRSEMLEVISDFPVFRNSYGEILVNPKGSPVFTGEYTPAGQFLLETQENYNGHARFAYQTTNNNWTARYSLSVDDFSMTGLMIVDLGVEPPSTITLVSSNPEFGYSARESSSKMANASYSISPTTSGAETRLYEISVPLSRGINYISFLSRFVEGEKRLVFRANWGASNYTGVDIDVRLKEVPLDLPSGIIDIWSDSVYLGSAGIGNIAEGENISLESVAKSIEIAGKKISETMKTDSTYRYIRNTYYVRNLSEETSAVVIEDYLGQNVDQINMENNEKFEYVKAEGKWSAVITVEPDQIAEVKVDYRVRYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J1</accession>
    <name>I2F2J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pullulanase</fullName>
            <ecNumber evidence="3">3.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-dextrin endo-1,6-alpha-glucosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pullulan 6-glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.</text>
            <dbReference type="EC" id="3.2.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0416"/>
    <dbReference type="EnsemblBacteria" id="AFK06144">
        <property type="protein sequence ID" value="AFK06144"/>
        <property type="gene ID" value="Theba_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0416"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004744_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011840">
        <property type="entry name" value="PulA_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02104">
        <property type="entry name" value="pulA_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="390"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="850" mass="96030" checksum="E9D0E8DE85CE7CA3" modified="2012-07-11" version="1" precursor="true">MKRVLFFLLLIFGTTIFAFTGESMGKSAEDYDAATVIIIHYHRYDDNYDGWNLWVWPDKPKSMDGKSYSFDRRDEFGVVTTVKFSEKHSRLGFIVRLREWEKKDITADRFVDIPDSGVAEIWVIEGEEDFLTSPDRIDLTPRVKMAFLDSLSEIYASLSAPVDTKTVLPEVLLDGSPVKVQSFEKADPTDVSVTNYVKITLTEPLAPKSVSKRLSLEIEGFLPGNIIVRKALDNSEFFYQGELGSIYSEKETVFRVWSPVSSSATLILFDDLYSDSFIEVPMKRIEAGVWEAIVQGNLHLRAYKYRFVSYGKERETVDIYSRAVTKNSERSVVVDPAKTIIEGWAQQKVPIFNKPEDAIIYEIHIGDMTSDPNTNVENKGKYLGLTETGRTGPDGVTVGIDHIVELGVTHVHIMPFNDIHYLNEGEEGEYGWGYDPYLYMVPEGHYSTDPYSPLSRILESKAMVMAFHEIGIRVILDTVYNHTATTGSSSPFDQTVPYYYYRTDATGAYLNGTGVGNEIASERPMMRKHILDSLKMWVNEYGIDGFRFDLMGLIDKETVLAIDRELHAIDKTILLYGEPWGGWGATVTFGKGDQRGTGVAVFNDNLRDAIRGSVFDEKVKGFSLGSRAKERRIMRGIVGSIEYSSDIKDFADDPSETINYVSAHDNQTLWDKNSAAMPDASRELLTSAQKLSNAIVILSQGIPFLHGGVDFARTKFGNDNSYNAGVDLNKMDYSRKAEFIDLFTYYKGLIELRKNHPSFRMSTAEEIRKNLKFLDAPRNIVAYVIDGKSAGDSWEEILVIFNGNLEPAEITLPDESWNLVVDRDRISEKPLERLSGKVKLEPISTYVFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J4</accession>
    <name>I2F2J4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">Theba_0419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730262.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0419"/>
    <dbReference type="EnsemblBacteria" id="AFK06147">
        <property type="protein sequence ID" value="AFK06147"/>
        <property type="gene ID" value="Theba_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0419"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_0"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="63" mass="7020" checksum="07B2E037C1F38A17" modified="2012-07-11" version="1">MSKVCEICGKSPTTGNMVSHSNKKAKRWWKPNVHKVRAVVDGEVKRIRVCAKCLKAGKVTRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2J7</accession>
    <name>I2F2J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">topA</name>
        <name evidence="12" type="ORF">Theba_0422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730265.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0422"/>
    <dbReference type="EnsemblBacteria" id="AFK06150">
        <property type="protein sequence ID" value="AFK06150"/>
        <property type="gene ID" value="Theba_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0422"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_0"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="739" mass="84225" checksum="9B5F1701BE9B56B0" modified="2012-07-11" version="1">MPDKLVIVESPAKAKTISRYLGKNYEVTASKGHVRDLPESNIGLHPETLEPTYEILKGKEKVVQELSKKSKGKQVLLASDLDREGEAIAWHISELLGLPQNEKNRIVFNEITESAIKEAILHPREIDMSKVEAQVARRVLDRIVGYKISPILWRTMKRGLSAGRVQSVALKFMVELEKKIVVFEPHRFFKIFAKVGEDRFSLSRIEGKKFTNKSVITEEKRDEIISELSNTIFHVKNVKERTSKRNAPMPFITSTLQQSAISELGWSASKTMKIAQQLYEGIETDQGQIAFITYMRTDSTRISNQARDKAVEIIESKFGKEYVGPIRPGKKGKKIQDAHEAIRPTYPENDPEKARQLLSGDNLRLYALIWNRFIASQMASAEYSVTEVELEDENDKYILSLTGERRLFDGYEKIVSRSSKSEIDRDYKIGEKIKPSMIEWEEDTTKPPSRFSEASLVKELEKKGIGRPSTYATIITTLLDRKYVLRQSRELRPTLLGAIVNEFLNEYFPDVVDMNFTANMEEELDDVENGAKKWRDVVMGFYSGFKTDLDEIDKRIKKGELRIEFPTDKECSCGGYFKVVFGRYGGYLKCESCGKNESVDMTSFTCVIDGKVMLKDVAANQKIEIEIEEKCPECGSPLVIRKGRYGEFIACSAYPKCKYTRNVRIDAPCPKCGGVVEKLRSKKGKNYFKCSSCGELFWNEPTNEKCEICGSYLFLKVKRGGKKVLYCEKCKKEFEIGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2K3</accession>
    <name>I2F2K3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">Theba_0428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730271.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0428"/>
    <dbReference type="EnsemblBacteria" id="AFK06156">
        <property type="protein sequence ID" value="AFK06156"/>
        <property type="gene ID" value="Theba_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0428"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_0"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="409" mass="45242" checksum="1C1CD2F16DB371C0" modified="2012-07-11" version="1">MKILVINCGSSSIKYQLLDAASENVLAKGLLERIGISGSKLSHRKGEKKYEFEKDIADHTEGLELIIEVLQSEETGVVKNINEIEAVGHRVVHGGERFASSVLIDDEVVSEIEANNFLAPLHNPANIEGIVAAKKILPSVPHIGVFDTAFHQSMPESSYLYAIPYDLYRKYKIRKYGFHGTSHRYVAERAAVMMERPLKELKIITAHIGNGASVAAVKNGRSVDTSMGFTPLEGLVMGTRSGDIDPAIVPFLQEQEGLSAGEVNDLLNKESGMYGLTEGRFSDMRDIEERAMKNEPTCKRAHDIYEYRLAKYIGAYAAAMNGVDAIVFTAGVGENSPYLRANVIDKYLGYLGISIDVEKNKIRGKETMISTTDSKVKVFVIPTNEELVISRDTSRIVKNGLKELKLWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L3</accession>
    <name>I2F2L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pfp</name>
        <name evidence="10" type="ORF">Theba_0439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730281.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0439"/>
    <dbReference type="EnsemblBacteria" id="AFK06166">
        <property type="protein sequence ID" value="AFK06166"/>
        <property type="gene ID" value="Theba_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0439"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_1_1_0"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="8"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="45157" checksum="713B3E229895CF9F" modified="2012-07-11" version="1">MKNAVYAQSGGVTSVINASAYGTLVAALESKEIDRVFAGINGVKGILNEDLYDLTEEARSEIDRIPYTPGAVFGSCRTKIDSDEDFEKLFKVFDAHSIRYFFYNGGNDSMDTAHKISKKAKEIGYELQVVGIPKTVDNDLLETDHCPGYGSAARFTAISIMEATRDLKSMYSDSTKVFIMESMGRNSGWLAASGSLASTDRFHGPQIILLPEVPFMEDSFIAKVEEVVKKEGYCSIVASEALKRPDGSFISTAGYYDSFGNVQLGKIGQYLEKIIRDALKCKVHVALPDYLQRSSRHVASLIDWQEAVEVGALAVREAIRGESEVMISINRLRSKPYLKEYTTVALELIANGTKDLPVEFISEDGFYVTDEFRSYALPLIQGEAPNLYLNGLPMYENLQKIRARKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L5</accession>
    <name>I2F2L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0441"/>
    <dbReference type="EnsemblBacteria" id="AFK06168">
        <property type="protein sequence ID" value="AFK06168"/>
        <property type="gene ID" value="Theba_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0441"/>
    <dbReference type="HOGENOM" id="CLU_3345762_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="37" mass="4378" checksum="DFE3E871EB25EA1D" modified="2012-07-11" version="1">MIEKELKKVESDKQNVLELETDRTLNLLEVTFEDRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N9</accession>
    <name>I2F2N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">Theba_0466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730306.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0466"/>
    <dbReference type="EnsemblBacteria" id="AFK06192">
        <property type="protein sequence ID" value="AFK06192"/>
        <property type="gene ID" value="Theba_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0466"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_0"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="170" mass="19107" checksum="533AE1F3A004EE5A" modified="2012-07-11" version="1">MDLESFVRDVPNFPKEGVVFKDVTPLLKDPLAFRECILRLSEKAMKVDFNIMVAPEARGFIFAAPLAFEIGKALVPVRKPGKLPYKTKEIEYELEYGRATLQMHVDAINRGDRVLIVDDILATGGTMQAIAEMIEESGGEVVEILCLAELGFLEPRKRLSRYSVETLITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2T8</accession>
    <name>I2F2T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730348.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0518"/>
    <dbReference type="EnsemblBacteria" id="AFK06241">
        <property type="protein sequence ID" value="AFK06241"/>
        <property type="gene ID" value="Theba_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0518"/>
    <dbReference type="HOGENOM" id="CLU_2862626_0_0_0"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="64" mass="7483" checksum="96334EEBA91F7289" modified="2012-07-11" version="1" precursor="true">MRQLWNRNWPLRIDLSSLVDLIEQKGGLKISTPDGSLDGTYFVGYSSFERFIREKTWRGLESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z2</accession>
    <name>I2F2Z2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730388.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0576"/>
    <dbReference type="EnsemblBacteria" id="AFK06295">
        <property type="protein sequence ID" value="AFK06295"/>
        <property type="gene ID" value="Theba_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0576"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_0"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="187" mass="20839" checksum="A8EBB246B854C50C" modified="2012-07-11" version="1">MARLILGSSSPRRRELLHLLRVSFEVIPPKGVEENLSERFCEKELCELSHLKAKNVMLRNPFSTVIAADTVVVLDGLVLGKPSSVEEAYEMLLVLSGRTHSVFTSVSVMYEESEFSFVEKTDVTFREVPSEVLKEYAESGLSLDKAGAYGIQDYGALFVKSIAGDFYNVMGLPIGRLWHELHARGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F307</accession>
    <name>I2F307_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730397.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0591"/>
    <dbReference type="EnsemblBacteria" id="AFK06310">
        <property type="protein sequence ID" value="AFK06310"/>
        <property type="gene ID" value="Theba_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0591"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372062_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658271" evidence="5">
        <location>
            <begin position="19"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="747" mass="82058" checksum="40EBC1C4AD30142B" modified="2012-07-11" version="1" precursor="true">MKKIALLASLLFSVVLFSIEYSPDSKAFSATSVAVSLDGEKLVAGYIDNTIKVWSLLDGKLLNNLSFNSSWVTAVAVSPDGKKGIAGYDDGMIIVWDLATGRKIKSLSSHTSTVNDLIVTKDSKTLFSCSSDATVKIWSLADLAFIRTLRGHSGSVFSIVDWPEQSRLYSASEDGTLRIWDSSTGQQVKVIRAEIGALTAVSMDEGRSILILGSEAGQLKSYDVKTWSSLKTTRAHNAQITKILIDNEVVYTASSDRTIKLLSLPSFSLIKMITGHTWDVTEIALSMDGHVLYSSSTDGKLKVWDIEKASAIGTLIGFGDGEYFSYNSQGNWVSSSLAKERVTCENGSSPAEVGKELSSILLQLDKLPRIYTTSEQEINLEKSTVSFAVSQPVIRVTVDEEEVAIGEDGGVVFSPDGEGTYTLRAYDSSGSYDERILTVHFEETVMYVVKEISSYQRGDKVLVDNYRNNEFLVNGEWVDETFLSISPPDLEPPIIIGERTQKVSIGKDKYLTFSVSDNGTLTAAEVIAPDLTVSRRTLNSTSTEVVIEVNGTGVYTVNAYDSDGNKTVATFYLEGEEEPFWVSKDYGSLRKGQQVKVAEEGESCYYVSDYGWVEKDCLSRSPVTTGEPIIDGIPVQYASSAGEKILSFKVSDDVNVKEVVVSGKAYPVNEREREMHIIVNEYGEHLVVAKDVEGNSSEAIFTLSAPDKNEKSNRSLFLLLIPILTLAVLIYIWVVRSSRKKNRKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F326</accession>
    <name>I2F326_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730407.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0610"/>
    <dbReference type="EnsemblBacteria" id="AFK06329">
        <property type="protein sequence ID" value="AFK06329"/>
        <property type="gene ID" value="Theba_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0610"/>
    <dbReference type="HOGENOM" id="CLU_2396247_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="93" mass="10358" checksum="67A5069DC9B46EA6" modified="2012-07-11" version="1" precursor="true">MKNFFRLLLLFSATVTVIFSLSSCIVVDNPVVFRVPFEELKGGAYYGGSLLFSPSDMLISHLGEGTPIAFQDLRMEWAPEEGSSIAERNYGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F342</accession>
    <name>I2F342_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06345">
        <property type="protein sequence ID" value="AFK06345"/>
        <property type="gene ID" value="Theba_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0627"/>
    <dbReference type="HOGENOM" id="CLU_3201875_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="45" mass="5013" checksum="8DFE8D04E9A994CE" modified="2012-07-11" version="1">MDSFEPHAFARIGAGKFVVVGAKSTDENGRQAYWILVDFQESFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F359</accession>
    <name>I2F359_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein Theba_0645</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492300.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0645"/>
    <dbReference type="EnsemblBacteria" id="AFK06362">
        <property type="protein sequence ID" value="AFK06362"/>
        <property type="gene ID" value="Theba_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0645"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_0"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="27703" checksum="1690F422BDA9BB8D" modified="2012-07-11" version="1">MSGHNKWANIKHRKGAQDAKRSKVFTKIIRELMVSAREGGSDPNTNTSLRSAIEKARSANMPKDTMEKAIKKGAGELEGQSFSEALYEGYAPGGVALLIRCLTDNKNRTAQEIRHTLSKYGGSMAESGAVSWMFERKGVITVAKEQISDLEEFQLLAIEAGAEDIKDEEDPIIIVTSPESVSDVKTALEENGYTLSYEMSYIPSNSLKVEGSDAAKLLKLLDILEDNDDVQEVYDNSDIDETEMEALAEQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F363</accession>
    <name>I2F363_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730442.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0649"/>
    <dbReference type="EnsemblBacteria" id="AFK06366">
        <property type="protein sequence ID" value="AFK06366"/>
        <property type="gene ID" value="Theba_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0649"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_0"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="203" mass="23030" checksum="8292E73F918D204A" modified="2012-07-11" version="1">MYIYFVRHGETEWNNSNRWQGRSDIPLSEKGRKQAEITGTFLKKHVPSVAAIYSSDLKRAKETAEIIAVSYAETPVANPVLREADVGLWNGLEISEALKCYGNLIEKWRKDPWANIPGTEPLGEVQRRAAGFIRYLSGNFQGKHVIVVSHALLIRTAICYAAGLPLENHYRLSLHNCSISTIKIEGAEMRLLEVNLWRHMEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F398</accession>
    <name>I2F398_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="9" type="ORF">Theba_0684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730467.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0684"/>
    <dbReference type="EnsemblBacteria" id="AFK06401">
        <property type="protein sequence ID" value="AFK06401"/>
        <property type="gene ID" value="Theba_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0684"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_0"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="141" mass="15715" checksum="19DB8E319903A582" modified="2012-07-11" version="1">MLMPKRVKYRKQQRGKMNGKAKGGTIVHFGEWGIKALEPHWITAQQIESCRIAITRTLKRNGNLWIRIFPDKPITSKGIGVRMGKGKGDVEGWVAVVKPGKVMFEIGGVPDQLAKEALEKAASKLPIRTKIVPRYQIGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B0</accession>
    <name>I2F3B0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">Theba_0696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730474.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0696"/>
    <dbReference type="EnsemblBacteria" id="AFK06413">
        <property type="protein sequence ID" value="AFK06413"/>
        <property type="gene ID" value="Theba_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0696"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_0"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="148" mass="15834" checksum="770C938AB5CCC14E" modified="2012-07-11" version="1">MAFKVEDLSPTPGSRTSEKRIGRGIGSGMGKTATRGHKGQGRATGKVAARFEGGQTPLFRRTPIKGFKNRGAVVYATVNISTLEERFESGSEISPEILVQRKILKDLKDGVKILARGELTKSFIVKANAFSATAKEKIESAGGKAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3C5</accession>
    <name>I2F3C5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Theba_0711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730486.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0711"/>
    <dbReference type="EnsemblBacteria" id="AFK06428">
        <property type="protein sequence ID" value="AFK06428"/>
        <property type="gene ID" value="Theba_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0711"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_1_0"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="130"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="245"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="367" mass="41164" checksum="9C520E7C79234C3E" modified="2012-07-11" version="1">MKFVAARSEILTRLESVSGAVAPKSVKPILSGIYFSMKDDSTVKLQATDLETAITTELRPKHIDGRCDFVIDARLVLEIVRNLPEGEVVFETEDTNVIIREGSARFTLPTMDPEEFPIVEPTSGGLEFTVSVSSIELMIDRVIFCAARDEFMRNLNSVYWEFEDGYLRLVAADGFRMALSEERIDLSIDDHFLLTLKSMKDLQNSLKAAMSDLLKVTYDGSRVQFLFDGTEIVTKVVDAEFPDYKKVLPKSFKARLVLSTEVFSDAVRRASIAARLGSDSVKFEIDDEQFKIVARSPDHGESIEILDANKEGDNIVIAFNPRFLSESAKKIDSDTVELNFVDSNSPLQMNPVDVQGYTYVIMPIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3D5</accession>
    <name>I2F3D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730496.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0721"/>
    <dbReference type="EnsemblBacteria" id="AFK06438">
        <property type="protein sequence ID" value="AFK06438"/>
        <property type="gene ID" value="Theba_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0721"/>
    <dbReference type="HOGENOM" id="CLU_1600765_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="166" mass="17961" checksum="F89D2C9F95F02080" modified="2012-07-11" version="1" precursor="true">MKAVISLLIVFLMSSLGLASLIIDGIHYSGFGSEDKLVYDGINVAYVLSQTGKNSLELGGNFSFVSPVSSEDFYINGHFNTLLKLFAGQAYDLTEESAVGLRVVSRAGLITTNVDKFGIFFSITPIAYVRVGFLSFGAAVGLELEKFFGMETLPVFHAGGEISYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H1</accession>
    <name>I2F3H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease, DNA polymerase III, epsilon subunit family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730528.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0759"/>
    <dbReference type="EnsemblBacteria" id="AFK06474">
        <property type="protein sequence ID" value="AFK06474"/>
        <property type="gene ID" value="Theba_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0759"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_7_2_0"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="182" mass="20220" checksum="BF97333309C29CA4" modified="2012-07-11" version="1">MEFVVIDTETTGMNPYRGAKLIEVAGVRVKNWELCRDDFFDSLIDPECIIPIAITALTGISNLTVKDKSTVCDVLRGFYSFAGDATLVIHNAPFDLSFINFYGDKCGLGKLRNQFIDTIEVSKAVFRYGRNNLDILLARLGIIPESRHRALGDALATAEAFVAMLNRIGTNNVTRFIKKPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H4</accession>
    <name>I2F3H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730531.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0763"/>
    <dbReference type="EnsemblBacteria" id="AFK06477">
        <property type="protein sequence ID" value="AFK06477"/>
        <property type="gene ID" value="Theba_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0763"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_0_0"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="21311" checksum="FF9C9A959051A419" modified="2012-07-11" version="1">MERGAEEIYELGELDLREFERIAKKIGEMLEGGETVLLFGDLGSGKTTFVKSMADGLGIDRDYVRSPTFNIVNSYPRLSSRKEDNENPVEVERPGLIHVDLYRVESEEEMLDLALHDLVDLDTVVAVEWPELYVKYVSQPYLIVRLEHCDESTRSVRIEPHGRKMKSLLNRLVTIINEDERREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I9</accession>
    <name>I2F3I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730546.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0778"/>
    <dbReference type="EnsemblBacteria" id="AFK06492">
        <property type="protein sequence ID" value="AFK06492"/>
        <property type="gene ID" value="Theba_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0778"/>
    <dbReference type="eggNOG" id="COG1875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022283_2_1_0"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="428" mass="48509" checksum="D14FB846FD78A068" modified="2012-07-11" version="1">MIKDFILDTNVLVHDPYCFDNFEDNNLIIPFPVLEEIDKLKKNSGSVGQNARKVNRFLDSLRSKGRLTEGVRLESGGTLRIAVFNEFKSQLPPFAASGYKDNAILLYMKELELVDKLPVILVSKDINMRVKADIMGMKAEDYLHDKVEIDDKLSGVHTFDDSALRDKFIDRDELSVDELSDSVGANEFVDFGKGIFGRVTPDGEMIVPLEVTMDTSNWGIKPRNYEQMMAMELLLDDRVRVVFIPGIAGTGKTLISLACGLRKVVDEKKYERLLVARPIIPMGQDIGYLPGSMEEKIDPWMTPIYDNLYLLFSNRHMDMDSFLKKREQLEVEVLSYIRGRSIPNQYFIIDEAQNLSPHEIKTIITRVGENTKIVVIGDPYQIDNSYLDAYSNGLTYAASRFRDKELAGHITLMKGERSELASLAADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3L2</accession>
    <name>I2F3L2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="6" type="ORF">Theba_0801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730567.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0801"/>
    <dbReference type="EnsemblBacteria" id="AFK06515">
        <property type="protein sequence ID" value="AFK06515"/>
        <property type="gene ID" value="Theba_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0801"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_0"/>
    <dbReference type="OrthoDB" id="2069770at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="44" mass="5265" checksum="EC2486C012507F38" modified="2012-07-11" version="1">MKRTYQPSRVKRNRTHGFLVRSRTVGGRRVLASRRRKGRKRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M6</accession>
    <name>I2F3M6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_0815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492515.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0815"/>
    <dbReference type="EnsemblBacteria" id="AFK06529">
        <property type="protein sequence ID" value="AFK06529"/>
        <property type="gene ID" value="Theba_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0815"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_0"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="293"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="527" mass="60020" checksum="8A9D18B0506DC324" modified="2012-07-11" version="1">MKKYVVVTGGVISGIGKGILSASIARVMKECGVEVNTLKIDPYLNLDAGTMNPNQHGEVFVTEDGYEADLDLGHYERFLGKNMRRENNMTAGQVFKSIIDKERKGDFLGATVQMVPHVTDEIKSRIRKVPGDLIMIEIGGTVGDIEGEIFLEAVRELWVEEGPENFLFIHVTYVPYLRVTNEFKTKPTQQSVQLLRRIGIQPQMIVVRSELPIEENELGKIALFGGVERQMVYNLPDSENVYDVPRIVYSHGIHRKIASWLNIEIEERFEWNYPKSFAPTRVAIVGKYLGTDDAYKSISESITLCGASKPEVIDSQCFEDMTDAQIKAELRKYDGIIIPGGFGKRGIEGKIAVIKAAREEDIPILGICLGMQLMVIEFARNVCKLENANSTEFDPSTPYPVIDLMEEQKAILKLGGTMRLGAQETPIEEGTTLYEAYNERLVYERHRHRYEVNLERFPDLFRTPEETDESKLRISSRATFVEAIELPEKRFFVGIQYHPEFRSKVGRPNPIFELFLTRVREKRRIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3N1</accession>
    <name>I2F3N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">Theba_0820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730580.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0820"/>
    <dbReference type="EnsemblBacteria" id="AFK06534">
        <property type="protein sequence ID" value="AFK06534"/>
        <property type="gene ID" value="Theba_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0820"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_0"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="306" mass="35020" checksum="D7E5F95FFDDFFB60" modified="2012-07-11" version="1">MIPLVLGPTAVGKTSLLLEIAGRLPIEVISVDSRQIYRFMDIGTAKPTRTELSLLKHWLIDIRNPDESFDVMEFRKLSLEFIAEIKSRGKIPVLAGGTGLYADALIRGLADVPARDENIREALLQIESQKKGFLRELLRKVDPKAFETIHENDLKRTVRYLEVFLRTGKPLTEFHKESEMSGEFGIVILQRERDELHRRIEARVHRMIDSGLAEETERLLEMGYAPELNALKTIGYAEMVQYIKCGVSLTDTSERIIVNSRRYARRQIIWFRRYREALRIDLSTLGNEAAQVLENTILSVWGGKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3T5</accession>
    <name>I2F3T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">Theba_0878</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0878"/>
    <dbReference type="EnsemblBacteria" id="AFK06588">
        <property type="protein sequence ID" value="AFK06588"/>
        <property type="gene ID" value="Theba_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0878"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_0"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="300" mass="33874" checksum="955270525D5359D4" modified="2012-07-11" version="1">MSVKSGTVALVGKPNVGKSTLINTIIGEKIAIVSDKPQTTRNRIGGILTTKKGQIVFYDTPGIHKPLHRLGQYILKVATSSLAGSDLLLVIVDPTDGLRESDRLVANHVNQSRIPVFLAINKVDEYKNERLLQDFQAKAEELFNDIRRTFLISAKKGDGVEELLETIFDFLPEGKMLFPEDLITDRSSRFMASEVIREKVLQNTRQEIPHSVGVVVQEFSDEGNILKIRADVIVERSSQKPIILGKGGSMIKIIGTEARKDLEYIFDQKIFLDLFVKVREKWRDKDTLIQEFTNLRDELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X4</accession>
    <name>I2F3X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_0920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730650.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0920"/>
    <dbReference type="EnsemblBacteria" id="AFK06627">
        <property type="protein sequence ID" value="AFK06627"/>
        <property type="gene ID" value="Theba_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0920"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354446_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
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        <property type="project" value="UniProt"/>
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    </dbReference>
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        <property type="term" value="P:signal transduction"/>
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        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
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        <property type="entry name" value="HD_GYP_dom"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="5">
        <location>
            <begin position="310"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="7">
        <location>
            <begin position="601"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="623"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="792" mass="87992" checksum="4AE26415369F72AF" modified="2012-07-11" version="1" precursor="true">MPLMRGPSSRLSKRLTGFAAGLSGFAVVVISVVLILLLGVLLSFAEIARGRREFSDRLLRQGRFVQSGLNLDELSRLSGSIDDLDKPEYWRLKSQLEQEYALFPEYRFIYLMGQKENGELFFFIDSEPYGSDDESLPGDIYVDATEYDLEVFREKKAKVLPVITDSWGTLVSVMVPVIDENSGRLLAVLGIDVEANDFWKTVLSYAIKPAVFSLVLVLMAILSGFFIIRRGKLSQEKKGKRVQRYLEAIVFAAFGLAATVMVSSLVRDRQEAARNDAFADLAATHVTSLSRAMKNTRDFQVEALARFFESSSFVSRQEFRNYVGSLSKSNELISWFWIESVSSGGIESFEEGIRREGFPDFFVWEAGNSGAKERVPYRESYYPIQYIEPLESNRNLLGLDLGSLGSAHEVIEEAAGSKLMWASDPVVIPTDEEKDLHFIVFKPILAESAQGHAGFVGAIFHSHAFHSAVPILPSDGDPTVILGLYQIGSGGNPVLLFSSAQESDSHVHENAETSIWHYPENRNIIAVPVMLFGRLFVILAHPGPDFGIVYPTNNWIFILAIGLTVTLSLAILIGSLGNRSFHLEREVGKRTEELRESLEIVSKTMEASVNVLASAVDLRDPYTSGHQRRVAELSVAIGRKLGFEENSLTGLRLSAMIHDVGKIQVPAEILNTPRKLTNLEFDLIKLHPTAGRELFKDIEFPWPVADAIYQHHERLDGSGYPEGISGDQIILEARIIAVADVVEAISSHRPYRPSLGLQSALDEIRSGKGKLFDPEVVDACLEVFDEGFSFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F406</accession>
    <name>I2F406_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="10" type="ORF">Theba_0953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730680.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0953"/>
    <dbReference type="EnsemblBacteria" id="AFK06659">
        <property type="protein sequence ID" value="AFK06659"/>
        <property type="gene ID" value="Theba_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0953"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_0"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="151" mass="16789" checksum="EABDDBD94864ED1B" modified="2012-07-11" version="1">MKVILLKDLSNVGKAGEVKNVSDGYGRNFLIPKGFAVEANAKEMAKLKQTQKQKEEKEERIRKASEELLHELQKHHFTIKAKSGVSGKLFGAVTSGDISNHIRSVIGVDIDKREIDLEDHIKQTGEYKVDVKLPGNVKGKIALKVEGLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F422</accession>
    <name>I2F422_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730695.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0969"/>
    <dbReference type="EnsemblBacteria" id="AFK06675">
        <property type="protein sequence ID" value="AFK06675"/>
        <property type="gene ID" value="Theba_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0969"/>
    <dbReference type="eggNOG" id="COG2379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_0"/>
    <dbReference type="OrthoDB" id="1358712at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="302"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="44438" checksum="540C95D5CEB17F04" modified="2012-07-11" version="1">MRELKKEAKYIVERSIETVQPESSVKNALEKLRLKGPIFLLAVGKAAWRMTKAAMDKLGEEVSAGIVITKYGYSQGDIERVEIFEAGHPILDRKTVEATDYALKRIEELKPEKILFLISGGGSALFEKPLEGVMLEDLVDVNNRLFRSGASIVEINTVRKHLSSVKGGRFAKLVSPSQVYTLVLSDVLGDRLDSIASGPAYPDSSTSDQALAVLEKYAIDVDSRIIEALMVETPDRLFNVQTEIIGSVARVCESAATFAREIGYNATILTTSLDCEARDAGVFLASIAREEAHNRPVEKPAALIIGGETVVHVRGRGLGGRCQELALAFSLGIGEMGGVTLACVGTDGTDGPTDAAGAIVDGRTVRKMLDAGIDPQLFLLDNDSYHALEKSGDLFITGPTGTNVNDLIVLLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F431</accession>
    <name>I2F431_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="17" type="ORF">Theba_0978</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492711.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0978"/>
    <dbReference type="EnsemblBacteria" id="AFK06684">
        <property type="protein sequence ID" value="AFK06684"/>
        <property type="gene ID" value="Theba_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0978"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_0"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="241"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFK06684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="449" mass="48531" checksum="66F8BF224CF3BB26" modified="2012-07-11" version="1">MTGIVLAAGQGKRMKSRFPKVVHKILDRPMVNWVISALRQAGSDRIVVVTGFEAAMVEAVLDKDIISVRQTPQLGTGHAVMTALDYLDDEDIVVIAGDEPLVLPSTLKKLVSRRIEGDFDVVFLTMKPADPTGYGRVVKDGKKIKIVEHRDADSETRMIDEVNSAIYAFKGSFLSSAIKSLSNNNDQNEYYLTDTISLADKADTIVVENAQEVLGVNDRIQLAEINKIAQKRINVEHMRNGVTIVDPDTCYIGPEVEIGADTVIEPMVFLSGKTRIGNCCSIGPLTRIDSSVIGDDVEILRSEVSNAEVHSGARVGPFSRLRPGAVVMNEAHVGNFVELKKTILGRGSKAQHLTYLGDTDVGEGVNIGAGTITCNYDGKRKHRTEIGDGAFIGSNTSLVAPVRIGKNSVTAAGSAITEDVPPDSLAFGRARQVVKEGKYSKNRGQEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F446</accession>
    <name>I2F446_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0993"/>
    <dbReference type="EnsemblBacteria" id="AFK06699">
        <property type="protein sequence ID" value="AFK06699"/>
        <property type="gene ID" value="Theba_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0993"/>
    <dbReference type="HOGENOM" id="CLU_3390222_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="32" mass="3752" checksum="8B2F39A0FD67F0BD" modified="2012-07-11" version="1">MNLLRRDDLTPKCPYCEGELTELYYKTKGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I2F452</accession>
    <name>I2F452_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">Theba_0999</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492737.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0999"/>
    <dbReference type="EnsemblBacteria" id="AFK06705">
        <property type="protein sequence ID" value="AFK06705"/>
        <property type="gene ID" value="Theba_0999"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0999"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_3_0_0"/>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="88"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="217"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="445"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="678" mass="75566" checksum="4563A44B71B78E21" modified="2012-07-11" version="1">MLSSEEIFKSMEIKLEDTLPPDPEFKPGIRRAPKRELTLSKKEIELALVNALRYIPVRLHEKLAPEFLNELLTMGRIYGYRYRPRGEIKGRPIEMYKGKCIEGKAFQVMIDNNLDFDVALYPYELVTYGETGQVCQNWMQYRLIKRYLEELTEDQTLVVMSGHPLGLFSSNKSSPRVIITNALMVGMFDNQEQWIRAQALGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRLKLGIGDEGDLGGHLFVSSGLGGMSGAQGKAVKIAGGVGIIAEVDRSRIETRLEQGWVDEVIEDPSEAFALAIEKMKSRESQAIAFHGNIVDLLEYAVNNDVHIELLSDQTSCHAPYDGGYCPQGLTFDERTELLRSDRKRFIELVDKSLVRHFSLIRMLVHKGTYFFDYGNSFMKAVFDAGAKEIAKNGTDTSEGFIFPSYVEDIMGPMLFDFGYGPFRWVCLSGKKEDLLKTDAAAMSLIDPDRRGQDRDNYIWIRDADKNRLVVGTQARILYQDAAGRRDIALKFNEMVRCGEIGPIMIGRDHHDTGGTDSPFRETSNIKDGSNIMADMATQCFAGNAARGMSMVSLHNGGGVGIGKAINGGFGLVLDGSERVDKIIRTSISWDVMSGVARRAWARNENALSVASEFNRQKRGSEQITLPYLVDEGIISKAIKEAETEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4B1</accession>
    <name>I2F4B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1059"/>
    <dbReference type="EnsemblBacteria" id="AFK06764">
        <property type="protein sequence ID" value="AFK06764"/>
        <property type="gene ID" value="Theba_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1059"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="270" mass="30402" checksum="BC75CED5534676EC" modified="2012-07-11" version="1">MVTSFMSEPTPDFSSLKLVDTHAHISFPQFDSDRDRVIRQIEDEEVSLLVEIGTNVDDSERAFRTVEGLRNAFFSAGVHPHDSSGLDKEGLIKLETLLLNDKGVAVGEIGLDFFRNLSPVEDQVRAFKEQLELAARLDLPVVVHVREAYSEAYEILKEFGHFKGVIHAFSADLEHARKFVQMGFFLGIGGPLTYKKNEGLREVVRQISLDRLVCETDCPYLPPVPFRGKRNEPYYVGYVIKEIANQKGISPISCSENLLNNALRLFSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G0</accession>
    <name>I2F4G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ORF">Theba_1108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730810.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1108"/>
    <dbReference type="EnsemblBacteria" id="AFK06813">
        <property type="protein sequence ID" value="AFK06813"/>
        <property type="gene ID" value="Theba_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1108"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_0"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="15"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="375" mass="41315" checksum="64C78A2D7572B1DF" modified="2012-07-11" version="1">MIDFQKLANEFGTPLYVYDAEKIRKRIKKAKTVFEGLDAEIVFALKANNNPALLKIMAEEEIGADVVSRGELLASKMAGMKRILWNGNGKTHEDITHFVNQGLNIVCIDSLQELPLWDGVNVIKLLRVNPDVDARTHPHISTGLRAHKFGVPIEKVSEVADRIDGIHLHIGSQITDVEPFFDAYSKALDCAKQYGFKYIDLGGGWGIDYEGKELDIERLQKGISGIFAGFDGKLIAELGRFIIGPAGYLVTKVVSVKPSEKIFIVTDAGMNALIRPVLYDAHHRIQVLASTKKTVTADVVGPLCESGDILARGRKLEVPIPGTAIVLENAGAYGFSMANNYNGMPFPAEVLVDGEEVKLIRRRQSIEELFTNVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P0</accession>
    <name>I2F4P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730881.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1196"/>
    <dbReference type="EnsemblBacteria" id="AFK06893">
        <property type="protein sequence ID" value="AFK06893"/>
        <property type="gene ID" value="Theba_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1196"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011771_1_0_0"/>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="410"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="610"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="756" mass="86266" checksum="2A36ED0D1A3BD47C" modified="2012-07-11" version="1">MDNDLQRLKSRIAEIEEANERLRNNSETPRTGNYMVSHYSSPAEKIALFRSLFFGRQDVYALRWESADGSSGYQPVCKNIWKKGICRKPQIKCSQCESREFAPLTDQVIYNHLSGRISVGIYPLLEDETCRFLVTDLDGDGWEEDAKVFANVCTSLSIPLYIERSRSGNGSHLWLFFKDAIKASIARKLCFELLNRVLESRPRLALGSYDRFFPNQDMLPKGGLGNLIALPLQGASRKNGNTVFLDDDFAPLADQWAHLSSIERIDFSKIADVLRELENSNTEKAINQVRQSKEIFPEQVTLKMDSMISIEKGSLPSSLINEILKLASFDNPEFFRAQAMRLPTYNKPRRISCADEEGDYFQLPRGCLYDSLDLLEKNGVRVNLIDNRSKGSDIEFAFLGKLTRDQDRAASEMLHHDFGILCAPTGSGKTVVGLELIAQRNRGTLILVHRRELLRQWQESACEFLQIPPEEIGQIGLGKNTAKGVLDIALIQTLARNEKTLKGLPDYGQVIVDECQHIPAFTLERVIKSIPAKFITGLTASPKRRDGHERILFMQCGPIRHLMGRKGKIFSERTYVPRQTNLETKADCKPKEIYRAIETDESRNALICDDITRAVEAGRYCLVFSERVQHIEILYELLCHLQNKVFLLHGKQPSKTQDESLDRFQHEINGAALLSTGRYLGEGFDDPRLDTLFLTFPISWKGVLQQYAGRLHRENFGKHEVRIYDYVDENVPMLKKMFENRKRGYKALGYREVVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4P2</accession>
    <name>I2F4P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1198"/>
    <dbReference type="EnsemblBacteria" id="AFK06895">
        <property type="protein sequence ID" value="AFK06895"/>
        <property type="gene ID" value="Theba_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1198"/>
    <dbReference type="HOGENOM" id="CLU_3218469_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="44" mass="4923" checksum="4C1AB720C643845C" modified="2012-07-11" version="1">MPGRAYQEVMPGETSGEVMLLRRKLVKQDVNGSPTRTKSQIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q7</accession>
    <name>I2F4Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">Theba_1214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730897.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1214"/>
    <dbReference type="EnsemblBacteria" id="AFK06910">
        <property type="protein sequence ID" value="AFK06910"/>
        <property type="gene ID" value="Theba_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1214"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_0_0"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="265" mass="30225" checksum="2FAFDB7FEFE33901" modified="2012-07-11" version="1">MGEKSINIRLNKALGQNFLKSDRVSRRIVESVELNPSTTIVEIGVGSGSLTSILLEKGYRVIGFEIDTRFSEGNRRLEGERCELRYEDFLKADLSTLPDSVTYVANIPYYITSPIIERIMFDGPSFDRAVLMVQKEYADRLTATPRTKEYGILTVNVNTFSEVRELFQVSRKEFIPQPEVDSMVIELSLLENPPIGEARRDQYRKFVRHCFSQRRKKLKNNLKSIVDLPEELLGSMAIGVDVRAEELSVDDFVSLFKNIYPEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4V5</accession>
    <name>I2F4V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type Fe3+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486615.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1270"/>
    <dbReference type="EnsemblBacteria" id="AFK06958">
        <property type="protein sequence ID" value="AFK06958"/>
        <property type="gene ID" value="Theba_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1270"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_5_0_0"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="28"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="309"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="508" mass="55710" checksum="C18D08F1DF0478EC" modified="2012-07-11" version="1">MPLFLAFGNLNFETIFSVVSSPSFKSIAGFTVKQSLLSTLLAMIVGFPAAVHYARSSGRLSSLLGITTYIPFFFPSISMAIGFLSVYGRNGIFNNFLSSLGFERVQILYSLGAVLLGHVFYNAPIVILVLGNALRKLPSDVLESSKIDGSGRIMRLLRVELPLVTPAIINSALLIFTYCFTSFAVVLILGGAQFATLEVSIYMNFRLLAAPQNAVVLAVVQFIFIMLFGLLISASEKSATFEQGEQYKEKNRFTAIYSWTFLLFEWLPILGALLSSFYDWTRGEFIFSRISKLFGEKLVLIGAGLTNTLINSLTLSALAALVTVTIAFLLSWQARKTIKGSKQLRIISLIALSVTPSILAVSYLTVFGGFPVPILILLLYIVISLPVVLNYISGQVIGAELNFLEAAQIDGASKIERLRYMIIPFFRSTIIYAATVVFAISMGEFGGSLILGSKDFPTFAVAIYRLNGSRYLLEARFLSSALGIIIISVVSVSRWFAQKPERSIRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z6</accession>
    <name>I2F4Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730971.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1311"/>
    <dbReference type="EnsemblBacteria" id="AFK06999">
        <property type="protein sequence ID" value="AFK06999"/>
        <property type="gene ID" value="Theba_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1311"/>
    <dbReference type="eggNOG" id="ENOG5033XT3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503244_0_0_0"/>
    <dbReference type="OrthoDB" id="2130793at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="564" mass="62428" checksum="F4649F10A1061D4F" modified="2012-07-11" version="1" precursor="true">MLANTNRKGFVLPFTLMMLGFTSIMLIAFGSQIGRLGSRLNSYERVSEIQLSTRNIIEIAAAYLVDSLEESVTFTSGNDWEDFDEFLEFASTRGGMEGTYWATVLRTLDSDDIEYWNLSNEADFVSHLNTDPSVFDTQDKGAVIYRHDKDTYSLISWTGTENTARRYSYGLFIRQYKLENPALELGSFERVLNQYRSGDDTTLWGDVVFGDVIIFDTITIADLSDPRKIFLGTVSASEVIPAFEGFDFTKPSTPVADYFEGLKNEHIDSLPSTTVEINLSSDDRVLPLVLDSNALPLDDETLLVVRIDPSIESVHKIRVEFEEDGDLVLSTLEVKNKKIEVKTSRRITGRDHKLFVRFDSDILVGDGDAKKMDLINGEYSITVVGDIDVTKSLVYEPLKSLFNNGNSINAQTDVSNKPLGQTEVNVSEVNSTLIAESSLIEGISLELVSIGGDINFFKETTSSHGVGVMHGDFKAFGNVNDDNPFDDYDDPLFPLTGGSIGLVVESEIDSKGSEFWVYGSLVGESFSSEDLSDFLKRFIAISRSEGAGSSSVSKGFSVVGIRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F521</accession>
    <name>I2F521_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">Theba_1336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486746.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1336"/>
    <dbReference type="EnsemblBacteria" id="AFK07024">
        <property type="protein sequence ID" value="AFK07024"/>
        <property type="gene ID" value="Theba_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1336"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_0"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="16632" checksum="0CCF1D6E025E4367" modified="2012-07-11" version="1">MERTFAYLKPNSIQRGLVGEIIRRIEEKGFKIVALKMLRISESRARELYREHAGKEFYEPLLAFVQSGPVVAMILEGEDAVKRLRVLVGKTDPTEAYPGSIRGSFGVSVRKNLIHASDSVESAEREARIFFDESEINDYSLVIEGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F530</accession>
    <name>I2F530_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion-translocating oxidoreductase complex subunit G</fullName>
            <ecNumber evidence="6">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rnf electron transport complex subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnfG</name>
        <name evidence="9" type="ORF">Theba_1345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnfG family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486764.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1345"/>
    <dbReference type="EnsemblBacteria" id="AFK07033">
        <property type="protein sequence ID" value="AFK07033"/>
        <property type="gene ID" value="Theba_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1345"/>
    <dbReference type="eggNOG" id="COG4659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155350_0_0_0"/>
    <dbReference type="OrthoDB" id="1381933at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00479">
        <property type="entry name" value="RsxG_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01947">
        <property type="entry name" value="rnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="8">
        <location>
            <begin position="122"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="6">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="240" mass="25782" checksum="6D8B77B3F1F4F21B" modified="2012-07-11" version="1" precursor="true">MRDYLKTGITLMVITIIAALVLSVVYTIVEEPIANAELGAKLKAIREVLTDSDTGELLIDEESIPQTATELAKFEWLPQGFSPSEGIIYRTEDNQGKVESPAYKFVKEDGTEIFIAIGIAVGYGGDVKSMAAFVKEPDGVKLNGIKVLEYSQETPGLGANIANADVQKRFYPVSKEGLDKGIRVDKDAGVTPVGDQIDARKREDGIVTVSDVMTGATITPRAVASSLNAISEFLDKAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F538</accession>
    <name>I2F538_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PEGA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486773.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1353"/>
    <dbReference type="EnsemblBacteria" id="AFK07041">
        <property type="protein sequence ID" value="AFK07041"/>
        <property type="gene ID" value="Theba_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1353"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775696_0_0_0"/>
    <dbReference type="OrthoDB" id="1105830at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658648" evidence="2">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4384" evidence="4">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="3">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="3">
        <location>
            <begin position="259"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="357" mass="39413" checksum="1953E53C9FD5F641" modified="2012-07-11" version="1" precursor="true">MKKALLLAIVFLSVSLFATSVSYDPQGLMFLSRPGASINVNVSLNKGMGSTYYGGESLGLSFSVDRSAYVAVLDIDPSGQIQVLFPNVYDQDNYLQGGRTYTLPTDKATTRYNLQVQSQRGRETIVVVASTSPLNFLGNVFSLFDRYPFPYLSQSINNLSVVIDPVFNTSWGLGYTYFYNSYVPFTVRTTINADRKDANVYVDGIFMGKSPVTTTLEAGPHTVYVYTERNLVYGPATINVQPGSSDFYFSLLPNYVYGYLEVTSIPDGQVYVDGQYAGDTPYKDFEKVGSHTVTVSKWGYHDSKQNVYINKDMVTSVSFTLTEKTEEEKKTDNIILFSIIGVLIAGVVIAVILGASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F557</accession>
    <name>I2F557_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731006.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1372"/>
    <dbReference type="EnsemblBacteria" id="AFK07060">
        <property type="protein sequence ID" value="AFK07060"/>
        <property type="gene ID" value="Theba_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1372"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_0"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="158"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="407" mass="43753" checksum="77733ADD293CC84F" modified="2012-07-11" version="1">MNERALKLHKDLRGKLEVRSRVKVDSMEALSLAYTPGVADVCRTIERKKELAYDYTNKWNYVAVVSDGTAVLGLGDIGPEAGLPVMEGKAVLFKEFANVDAFPLCIDVHTAEEIIFFVKALAPTFGGINLEDIASPKCFFIERELQRSLDIPVFHDDQHGAAIVAVAALRNALKVVGKKIEELKIATVGVGAAGGATIKMLLAAGARNIVAVDKNGILNRKDSRTLLNEFHSEIVREINPENLSGNLEDAVKGADLFIGTSVAGLLTPEMVRQMAPDPIVFALANPVPEIMPDLAKGAGAAIVATGRSDFPNQINNVLAFPGIFRGALDTRSREINEAMKLAATKALSSAVPEENLSSDYILPKPFEPGIARRVALAVAKASIESGCSRLSGNIDLDELIDRGLKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F571</accession>
    <name>I2F571_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1386"/>
    <dbReference type="EnsemblBacteria" id="AFK07074">
        <property type="protein sequence ID" value="AFK07074"/>
        <property type="gene ID" value="Theba_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1386"/>
    <dbReference type="eggNOG" id="COG3594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811171_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="323" mass="36626" checksum="6B73FB1F8BD44C33" modified="2012-07-11" version="1" precursor="true">MALVVMYHTLPPQIAANLINPAACTFFFLSGLISRDIPLKDSISKRFKQIMIPYYTMALANTAIWLIAKAIVPRQEMNFTLGSVIANVLTVRTAVGIIPLNIIPLWFLPAVFVMEIYYSLLRRLRILIVGITIGFVSMYFFYGSLPFKLDVALAVLPYFALGKFVRSRDLFSKRLSFLFTALACSLYIITSAFCNEVYLMEDYFGTLPFLYVIAALIGIIAVSGLSQILQKSKAVRNVLSLFGRRTLFVLGYHIAAGFLVYPLFDLIGDPIEIMERFWFAYWIINMGVLYLMIRYIPEPVITALSGSFLAKWQRNPEKLTHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F584</accession>
    <name>I2F584_9BACT</name>
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        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731032.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1399"/>
    <dbReference type="EnsemblBacteria" id="AFK07087">
        <property type="protein sequence ID" value="AFK07087"/>
        <property type="gene ID" value="Theba_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1399"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="234" mass="25741" checksum="5ADD5DE986DF18F0" modified="2012-07-11" version="1">MLEVKNLFVSYGRIQVITDFSFNVGAEAVGLFGPNGAGKTTLINSIIGLVKPRSGEILFEGESLLPYETHSIVRKGISVVPQDGELFPIMTVLENLKIGASYIKEARDKVNERLEFVFGIFPVLKERAYQLAGTMSGGQQRMLAVGRSLMAVPRLLILDEPSVGLQPTLVTELFEKLSMIKSEGVSMILSEQNVRQGLKVIDRGYVIENGTLAIESTADDLMHNEHVKRSYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A6</accession>
    <name>I2F5A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1423"/>
    <dbReference type="EnsemblBacteria" id="AFK07109">
        <property type="protein sequence ID" value="AFK07109"/>
        <property type="gene ID" value="Theba_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1423"/>
    <dbReference type="eggNOG" id="COG3181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045683_1_2_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657765" evidence="2">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="35357" checksum="55FE86C2C85AFC8A" modified="2012-07-11" version="1" precursor="true">MKKVLLFSLVLVIAASVLASYPNRSVTLVIPWAAGGITDRVGRAFAPYLEKYLGVPVVVLNQPGASGAIGTDFAYSKPADGYTLLLSAETPGVFRVMGTGKLGFDNFEGIMMLVEDTKVVVVPGNSPYQTMDELVTAIKENPGKIKMSYSGPGASGHIQGLLLEEVGLDVSMTPFGGGSPAMLATISGQVDFTFGNIGTVLDYLKTGDLRALAVYTKGERSPAIPDVPPIADAIPEMARYLPLTFPNCILVKEGTPPEIKQVILEAAQKAVQDPGWIEFTESSFYNRMHDVQGDAVIEYWKRWTSIVAWLLYDAGVAPNSPADFGIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C6</accession>
    <name>I2F5C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate starvation-inducible protein PhoH, predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006486967.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1443"/>
    <dbReference type="EnsemblBacteria" id="AFK07129">
        <property type="protein sequence ID" value="AFK07129"/>
        <property type="gene ID" value="Theba_1443"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1443"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_0"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="112"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="326" mass="37164" checksum="CB04049848E92D51" modified="2012-07-11" version="1">MAVRKLSLPMGVEVAELFGEYDRKAKYIQKKLDVRISIIGNEIWIKGEDGNGIDIAEKIVDELVQMSRDGHLVEWREFEYIVDQHLQHDEDDDSFKGVYNEVKETTLLSNRIRPKTIGQKNYMETMKERELVFSIGPAGTGKTYLAVAMAVDFLKSGKVQRIILTRPAVEAGEKLGYLPGTLLDKVDPYLRPLYDALMEMIPAEKLSYYRDSSIIEVVPLAYMRGRTLNNSFIILDEAQNTTYQQMKMFLTRIGFGSRVVVTGDITQIDLPRDSGSGLVVVQRVLKSVATIGFSYLTDQDVVRNPLVKDIIKAYDEYEREEKTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G0</accession>
    <name>I2F5G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal bacterial protein YeaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487026.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1480"/>
    <dbReference type="EnsemblBacteria" id="AFK07163">
        <property type="protein sequence ID" value="AFK07163"/>
        <property type="gene ID" value="Theba_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1480"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_0_0"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="219" mass="24476" checksum="D068490AD57F24FE" modified="2012-07-11" version="1" precursor="true">MKYICFDTSSRTLLLSAVSNAAEMDIRCRDIDRYGSMLAVIMRQAIENLKIDVSELEFVGVGIGPGSLTGLRVGISTAKGLAFPHGIPAVPFNSLDVLAKTVDSDRYLILRKAREDHYYWREYKGGLPVGNTGFSNTGMIKSKIELSTMELFFDGEIDPEFEDFRCSLVKNYDPSSMREIVLDTYASGNQVSCSDLAPIYLQKSIAEINWEKRSNEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G1</accession>
    <name>I2F5G1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487028.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1481"/>
    <dbReference type="EnsemblBacteria" id="AFK07164">
        <property type="protein sequence ID" value="AFK07164"/>
        <property type="gene ID" value="Theba_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1481"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063199_0_0_0"/>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="285" mass="30544" checksum="B11E35615B95DA78" modified="2012-07-11" version="1" precursor="true">MNRKTFIDYFLITVGSILTAMSIVSFMVPNNIIAGGVSGLAIIVYRVFGLWVGAQMFVYNIVLFLLAFVTLGVGFGMKSIYSAVLMSLSVDLLQKLSFPVFDASSTQDGFLLVAIYGGVIAGAGMGLVLWRGASTGGTDIVAMILSKYVGFSTGTGLLISDSLITLLAVVVFGPIAAMYGIITIFTTSKTIDGIIEGIGNTRTAFVISKESEAIKEKVINEMERGTTIIKATGGFSGEDRPVLMVSIRRREIGQLRHIVKTTDRRAFVVVVNNSEVFGEGFKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5G3</accession>
    <name>I2F5G3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="6" type="ORF">Theba_1483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731097.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1483"/>
    <dbReference type="EnsemblBacteria" id="AFK07166">
        <property type="protein sequence ID" value="AFK07166"/>
        <property type="gene ID" value="Theba_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1483"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_0"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="224" mass="25452" checksum="0D18F3DAB6DA0B3E" modified="2012-07-11" version="1">MIDEKNKKNPESIDNEEGVKEERNAARLDESDKLENTAGAATGEKVREGSEVREKAMNDSEVHDKSETSEIDELKALRDEIKNLKDENARLRAEFINYRNALVRESEESIRRYREKIIIRLIEIYDDLSRALENPDNSKKSLISGIKLIHKSVERLMFDEGLSMIMPEVGKPFDPFSHEVEGTISSNDVPDMAVYDVIERGYNLNGKVLKPARVVVAVNDSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M6</accession>
    <name>I2F5M6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase III PolC-type</fullName>
            <shortName evidence="11">PolIII</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polC</name>
        <name evidence="15" type="ORF">Theba_1557</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731138.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1557"/>
    <dbReference type="EnsemblBacteria" id="AFK07229">
        <property type="protein sequence ID" value="AFK07229"/>
        <property type="gene ID" value="Theba_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1557"/>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003297_2_0_0"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01405">
        <property type="entry name" value="polC_Gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="14">
        <location>
            <begin position="314"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="13">
        <location>
            <begin position="401"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK07229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1412" mass="158917" checksum="A6088EC51E3F91A5" modified="2012-07-11" version="1" precursor="true">MKLFLRNVGLPLSRLLSKALSIDSSFECEGIEISDISVDCKSKEIELAFQCEVSNEIKEFLESVFCEKASRLLESSVTLSFKTLTSEGEIPDEDAMEVTESQFREILQLTNGASSYLRSSEMEFKDNKITISVHDQFSFQRISSKKHDLRKAIDKVCKRSIPFEITLDISEDQDSPVEEVSFDREDNGETEHLEERSDSVLMGRSIRAVSVKMSEVLGNETNLVVSGRIFGLEYRNGKLSILTFNVTDYTDSLTVKLIGENARSLSEKLREGDEVTIRGKMETDSWMKEEILIPRDIVRTKLPKRMDNAMEKRVELHLHTKMSSLDSVVDVNDLVNTLKDWGHDAAAVTDHGVVQSIPEFYFAAKKKGIKPIFGMEGYMIKDSEQISMNLEKEDSPLESATFIVFDLETTGLNPKEDEIIEIGAIKMKGNEILETFSSFVKPQKELSSLITSLTGITEDMLSGAGTIKQVLPEFTKFAEGGILVAHNASFDYGFIRNSVKKYFGGDWEMPCIDTLALAKSLYRAKSYSLDNVVKRLKLGHFDHHRAYEDAKVTAEVLKKFLQQAKKRGVEKVNELEKLRKNQNLDSLKPVHISILSKNRKGLENLYKLVTASHTKYFYMKPRIPKSLLTDFREGLLIGSACISGELSKAYIGGASVDELEEIAKFYDYIEVMPLDNIDTSEGETSMSKETLIKMYREFYKVGKKLNIPVVMTGDVHFVNPHDDIYRAAINAAQDYDNFQNQPSLYLHTTEEMIGKALEIFEDEGIAKEIVVDNSRLIASQIENVVPIEGKLHPPVIEGADEEVRKMAIENAERLYGKPLPDIVEKRLNRELEAIIGHGYAVLYLIAQKMVKKSNEDGYVVGSRGSVGSSLVANVIGITEVNPLPPHYLCPECGKSVFPETDLESGYDLPAMKCPGCGNEMLKNGQSIPFETFLGFEGDKVPDIDLNFSGEYQEKAHSFIEELFGRDHVFRAGTISTVAERTAFGFVRAYSEKSGKTLRRAEQERIARGIVGVKRTTGQHPGGLMIVPKDMDVHNFTPVQHPANDTKSSILTTHFAYEVIHDDLVKIDALGHDDPTFIKMLKDITGVDPEKIPMDDEETLGIFSSLKPLGLRFHELGTDVGTLGIPEFGTTFVRSMLSDTRPSTFGELVRISGLSHGTDVWLNNAKDIITSGHASLSQVIACRDDIMNYLIGKGMEPKEAFKIMEKVRKGKGLSKEDEIEVRSCGAPEWFMNSCKKIKYLFPRAHAAAYVSMGYRVAYFKVHFPLAFYSTYFSIKGGEFDIDICTSDINSIKKEIVRLRSDQDRNVKDRAKETLLEVVMEMKLRGFSFLNVDLMESHPTRFLIEGNSLRIPLNRLQNMGDKAARSVEVEREKRPFSSVEDLIRRTALNKTSVEMLRKYGALKNLAEKEQIRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5M7</accession>
    <name>I2F5M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731139.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1558"/>
    <dbReference type="EnsemblBacteria" id="AFK07230">
        <property type="protein sequence ID" value="AFK07230"/>
        <property type="gene ID" value="Theba_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1558"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068031_0_0_0"/>
    <dbReference type="OrthoDB" id="1652855at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="39153" checksum="97B58026A87A56F1" modified="2012-07-11" version="1">MDFKISASDYAKLIDLFGRVSGTLEPSYRYFQIYYKRGLKFFASDGCMKLEFSSGVATSPFNGVYTVPIDYARALKSSDPTSLICFSAGEEDLELRTASETLTLQKARSSTLPAMERKFEFFSRFPLKEFSSSLNFVSSASVEGETVEIFSKKNETVLASSANRMVLVSVLEYEPKTEFRYSLQYVTVRHLVKALELLTSEELYAGTGISELGLKIGPLLFSICTDEADFSEPPSFFFGDTDDGNDVQRKAFLSALRKITRLSKHGFSVLMISDKSKLKFFLKAGALRYECEVCDFVGDEFVAQVDPRKLQSVISRIKDSKIRLVTRKGNLLMVGRKSKMYLMVPLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P1</accession>
    <name>I2F5P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-aminopeptidase/D-esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731151.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1572"/>
    <dbReference type="EnsemblBacteria" id="AFK07244">
        <property type="protein sequence ID" value="AFK07244"/>
        <property type="gene ID" value="Theba_1572"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1572"/>
    <dbReference type="eggNOG" id="COG3191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_0"/>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="331" mass="35328" checksum="6B05A902AA639246" modified="2012-07-11" version="1">MRFRELVSPPDAYETGPLNKITDLEGIEVGHFTLIEDAPRCLRTGISIVRISGVYGSPIPAACSVFNGYGKSMGLVQIEELGTVESDIFLTNTLSIGAVQQGAAKLALEDNPEMTSLNVVVMECNDGYLSDIRSLSIREEMVSKAVMDARKDFALGSCGAGTGMICFGYKGGIGSSSRIIEFDGRKYTVGAIVLSNFGRSSDLRIPSLELSNDSGSSAQGAGSLIMILGTDLPLMPHQLKRVSRHMSLAIGLLGAPGHHGSGDISLAFSTAREYSLRDQRLMKNENTISEIFRASAWACVEAIVDSMLSSDSMTGFKGSVKSLKSAVIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R1</accession>
    <name>I2F5R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07264">
        <property type="protein sequence ID" value="AFK07264"/>
        <property type="gene ID" value="Theba_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1599"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="416" mass="49251" checksum="8EEAAE435F54B59D" modified="2012-07-11" version="1">MLTDKMRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLKEFEADLDNNLYKIWNRMSSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWQYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIERWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERLEECKLELHPEKTRIVYCKDDKRKDEYPNTSFDFLGYTFRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSRLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S6</accession>
    <name>I2F5S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="10" type="ORF">Theba_1615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731178.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1615"/>
    <dbReference type="EnsemblBacteria" id="AFK07279">
        <property type="protein sequence ID" value="AFK07279"/>
        <property type="gene ID" value="Theba_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1615"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_0_1_0"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="87" mass="10258" checksum="2A36E7C14681DCEB" modified="2012-07-11" version="1">MWVIIVYDINEKRVAKVLKYLRRYLNWIQNSVFEGELTYAELKKVKSGLKRLMNTQEDSVIIFSSSLSNDYKKEIIGLDKAKETQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F633</accession>
    <name>I2F633_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane complex biogenesis protein, BtpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1652</name>
        <name evidence="3" type="ORF">Theba_1729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1652"/>
    <dbReference type="EnsemblBacteria" id="AFK07315">
        <property type="protein sequence ID" value="AFK07315"/>
        <property type="gene ID" value="Theba_1652"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07386">
        <property type="protein sequence ID" value="AFK07386"/>
        <property type="gene ID" value="Theba_1729"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1652"/>
    <dbReference type="KEGG" id="mpg:Theba_1729"/>
    <dbReference type="eggNOG" id="COG0434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075239_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="274" mass="30215" checksum="F1B3E404469B8463" modified="2012-07-11" version="1">MMKMFEEMFGKKLPIIGVVHLQPLPGAPRYEGMSMKEITRLAVEEAKTMVENGVDGLIIENFRDMMFKKRVGPETVASMTYVASEVVANLSVPIGLCVLQSDAISALAIAKAVGGKFIRVPYYTETYIVDAGMMESIAADALRFRKMIEARDVKIFADVHIKHGYSLSRRPIEESAEDAFERGLADAVIVTGKKTGGKTKPEDVKAVRDYLPKLPLIVGSGVTPESLSEYFPQLGDAVIVGTSLKKDGKTESPVDPERVRQFANHMEKCRKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F670</accession>
    <name>I2F670_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1701</name>
        <name evidence="5" type="ORF">Theba_1768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MesG1.Ag.4.2</strain>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731254.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07360">
        <property type="protein sequence ID" value="AFK07360"/>
        <property type="gene ID" value="Theba_1701"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07423">
        <property type="protein sequence ID" value="AFK07423"/>
        <property type="gene ID" value="Theba_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1701"/>
    <dbReference type="KEGG" id="mpg:Theba_1768"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050659_1_0_0"/>
    <dbReference type="OrthoDB" id="1497065at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="395" mass="45678" checksum="BD9CFFAFC243002E" modified="2012-07-11" version="1">MMFECRRISNQKDYLDLMKFSFGITENWMRVASKHAGEIFNNDLRDPFGAYDGSTLAAEYLLLSLKMRLRDSVIPMGGIGNVCTSPLYRGKGAVKFLLQKSLETMREKGQAVSLLYPFSRSFYRKLGWEEFDTMLRAKFSPGSIDLPDQKVEVKIEEMEDADGEIREFYNEYASSHYSMILRDEEMWKSDFEFRTDNDVSKKFVKFKREGRTTGMLRYVFLYDKFDKDSGLKFLVTIFLADDVETRHAMFRFLKGLSLQIDQIHAFLPPDFLLWPYLKERPSEMKIVPRTMIRIVDLQLLNGLRIDAPDMRVGIKIDDSQASWNDGVFELCVENGELSFSPSDSFDLECDISTLSSVVGGSTNFKEMIEFGRVKVSDGYKGQDLPKSLPFELQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F694</accession>
    <name>I2F694_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit Na+/H+ antiporter, MnhE subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731278.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1796"/>
    <dbReference type="EnsemblBacteria" id="AFK07447">
        <property type="protein sequence ID" value="AFK07447"/>
        <property type="gene ID" value="Theba_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1796"/>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_2_2_0"/>
    <dbReference type="OrthoDB" id="1987527at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="163" mass="18252" checksum="5139578214CF1889" modified="2012-07-11" version="1" precursor="true">MALQFISLLVISFIIWLGLAGSFALAEILLGLVVSTVVAIILSKYSRFRIGLDFPVRVFRFVFSFLPIFIMEMVKANIDVAKRVLNPSLPINPSMVEVETDLKGEISKLTLANSITLTPGTLTVDIGEDRLLVHWIDKKTSEPERIREEISGKFEKRIGGIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E0</accession>
    <name>I2F6E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731311.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1842"/>
    <dbReference type="EnsemblBacteria" id="AFK07493">
        <property type="protein sequence ID" value="AFK07493"/>
        <property type="gene ID" value="Theba_1842"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1842"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_2_0"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="211" mass="24001" checksum="1EB3613F12E4096E" modified="2012-07-11" version="1">MTRYVDLTRVIEDNQPVYPGDDQTRLHRSRVLSKDGYNNHRLEISMHSGTHIDGPLHLTQSNLYVDQIEIDRLIGKGILLDVRGETEITIKPQYEEAISEDSIVLFWTGRDSLFGSEDYFLKNPYLTSDLAEFLVERKTRMVGFDSSSPDRYPYDIHRILFHGGCFIAENLTGLENLSNSKELEIFAIPLKIHADSSIARVFAAVKQGGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E6</accession>
    <name>I2F6E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488340.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1849"/>
    <dbReference type="EnsemblBacteria" id="AFK07499">
        <property type="protein sequence ID" value="AFK07499"/>
        <property type="gene ID" value="Theba_1849"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1849"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="359" mass="40088" checksum="BEC1423CB1EB0E56" modified="2012-07-11" version="1">MSLILKNVRKVFTSYGTETVAVDDFDQEIRRGQLVTLLGPSGCGKTTTLRIIAGFEVPTNGRVLLDGKDVTNLPPNRRNISMVFQSYALFPHLTVEENISFGLKLKRLDRSTMKKKIREMTDLVGLKGLEKRRPDQLSGGQQQRVALARSLVMEPSVLLFDEPLSNLDAKLRESMRLEIRRIQQEVNITSVYVTHDQVEAMSISDIIVVMNDGKVMQIGSPFDIYARPQNSFVADFIGRVNFIDGEVESINGDSVTVSSSSLGKKFVGRKGGELSPGDGVRIVLRPESLSDREEDKINVLSGKVLKYVFLGSNVEYEIELPDGKILNAVTFNPIERKFPVVGKETDLYFSKESAWVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6E7</accession>
    <name>I2F6E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731315.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1850"/>
    <dbReference type="EnsemblBacteria" id="AFK07500">
        <property type="protein sequence ID" value="AFK07500"/>
        <property type="gene ID" value="Theba_1850"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1850"/>
    <dbReference type="eggNOG" id="ENOG5032KU4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862966_0_0_0"/>
    <dbReference type="OrthoDB" id="374736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="310" mass="36461" checksum="FBD751C023930B82" modified="2012-07-11" version="1">MDGHDVLTNKCMDMKKAFLSEEVEIKPYCYRAYDQGPYNSSKDGFEDYLGRPYLSRSDEELYLPFFDNKAPRSGRAPAWQILTVYSYEPDFGMDEGLSLSPLQKFMGGSGTWRHEEFHIILRFGEVTDRFLHFDRMSMLANEKGDRYWALRFAARALHYLEDCGTPYHASPGTPIEIFKIPFLYRKQFKKIGFYHKFHDRYLGYRLWRGYEPFLEEIEGTEAGVFDRLEKMAKTIRRRAFDLLPEVELSVKRLIGGNSFENPSPELSKEYYGKLVSSQDTRRLDEVSCKILRNLSSGVKFYLNHLERRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L0</accession>
    <name>I2F6L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731365.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1916"/>
    <dbReference type="EnsemblBacteria" id="AFK07563">
        <property type="protein sequence ID" value="AFK07563"/>
        <property type="gene ID" value="Theba_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1916"/>
    <dbReference type="eggNOG" id="ENOG5033H5S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244110_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="222" mass="25077" checksum="A0ED6A8364383798" modified="2012-07-11" version="1">MLLKTGILIFDVFIIILSVSLIKTAVGWYSLLLLGLYLFPSLRMLRLIPGFDEREKTIDSLSSNMALGISFVLAIFYIGMSYTLTIDAAISFILIPFVAKAVFFSGFTLERRQLVSIIGRSVGLIFVGFALFSHGFSTVALIEMLPGIVIIICTELSPRYRWFGLSYLFLIGIATWVYLPNFGRITSVLVYSLFVIPFSVLLVRSLRCLFTHCSSFRLVFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L4</accession>
    <name>I2F6L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731369.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1920"/>
    <dbReference type="EnsemblBacteria" id="AFK07567">
        <property type="protein sequence ID" value="AFK07567"/>
        <property type="gene ID" value="Theba_1920"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1920"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665352_0_0_0"/>
    <dbReference type="OrthoDB" id="1992791at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="45575" checksum="4EDCA393880B95ED" modified="2012-07-11" version="1" precursor="true">MRLKRVSIVIVAALVAMLMISSCIPKDPVVAATRKFIQFIEEEGEPEGPFTGLYLGEVDQDDIIGSESAGGQELQYQLQGINESGYFFYLDEAPGAFYDHPGKLVVVSKTNEIIFEEDTEGWPTINGNIVSPLSDRNLYAKAVIWDKWKYVREIITGTVVDWTQVFFRIKGAVITSGLTPTQNLYAEARDVRDLMSNAFKTIMGTDRVRDVKYVSGAAAPNWIAVLAAMDELLTTEKVNYMTLYFIAHGNTNLMNLGGTTFFANQLRTYILEHSGVKFCIIIESCHSGSWLEGLKSAGVIPPNVEIIITTTTATKGAYPDWDSAGGAADYNPSDMYVEWSGDFLQKLSSFTGTGWSEVTSYASSKSIDTLPALLYKCYTAIKGGSPSTTSWTLTERFVAGPVQQPMIYTKWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R2</accession>
    <name>I2F6R2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1972"/>
    <dbReference type="EnsemblBacteria" id="AFK07615">
        <property type="protein sequence ID" value="AFK07615"/>
        <property type="gene ID" value="Theba_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1972"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="531" mass="59415" checksum="9513E6484AB61294" modified="2012-07-11" version="1" precursor="true">MRRALIVMLVLIVGYGVVAMACTSILVGKDASVDGSTMVTHTCDGSYDARLQVIPGGVHEEGETVSIYKGLCQAGIPGRTVQYVGEIPQVPETYTYFHTGYPFMNEHQVIIGETTWSGERALRNSQGWMTIEQLQVLGLQRGKTAREVIQIMGELAEKYGYGDGGEGLTVIDGDEAWLFEICGPGPFWSPGSEEPGAVWVAQRIPDDHVLVHANRSRIGEIDLENTDYFMASPNVYSTAQELELWDGQEPFLFYAAYGPKNAFYNTRREWRVLDLLAPSLELDPWAERYPLSVKPDKKVSAQDLMMIKRDHYEGTEFDLTVGLAAGPFGNPNRYATPASARPEGINYDGWERAISMFRCSYVIVGQARNWMPDAIGGVVWFGEDAPHSTVYIPFYAGATSVPESFSQGARDFFDRSSAWWAFNHVSNLADLRYNVAIEIIKEEYTKFETEFLANQPLIEKVALDLYAENPEAAIDFITNYSNGLANRVVDRWWKLADELIYTLNDGYVDGKTVGYPTWWLEAVGYGDTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6S0</accession>
    <name>I2F6S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731415.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1980"/>
    <dbReference type="EnsemblBacteria" id="AFK07623">
        <property type="protein sequence ID" value="AFK07623"/>
        <property type="gene ID" value="Theba_1980"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1980"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_5_0"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="208" mass="23841" checksum="65FBF61F5C688467" modified="2012-07-11" version="1">MIENLIWDFDGSLFNTYPAMVRLFKQSLAIHGYGASEDEILSLMKETLGKAVDFYLDRGVDYAFYKDFQRMEEELDPVEQPPFSGAREVCSRIKRDGGVNLIITHRARRTAFKLLDYFEMTSLFSEIVTKESGFKRKPDPEAFISTIRRHRLKPESTLSIGDRDLDVMAARDAGTKTCFFSQDGSKPSIDVDYIVDDLLQLGRIIQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6U3</accession>
    <name>I2F6U3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2003"/>
    <dbReference type="EnsemblBacteria" id="AFK07646">
        <property type="protein sequence ID" value="AFK07646"/>
        <property type="gene ID" value="Theba_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2003"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_0"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="26310" checksum="DC2E818D0FEFBFAD" modified="2012-07-11" version="1">MTPERQRHLEAGFNRLKSMLSDMMENVRSSLLKAIDSLDRLDGDLARVVIENDEVIDKLQRKMDTEICNYIGRFQPLAEDLRYVLTMMKLATDLERIGDLAVNIAEVAVRYENQTLVKPLIHIKKMTAVVEKMLEEIIDAYYNKDTETAKRVWNEDNNVDEYYLYIKREVREKLVSMTDPNAIGQLLDLMLVSRFLERAGDHATNIAEEIYYIEKGESLKEEMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F712</accession>
    <name>I2F712_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731492.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2079"/>
    <dbReference type="EnsemblBacteria" id="AFK07715">
        <property type="protein sequence ID" value="AFK07715"/>
        <property type="gene ID" value="Theba_2079"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2079"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="252"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="496" mass="54587" checksum="0E1B2F8E9BE8A03B" modified="2012-07-11" version="1">MDDFILKMEGISKSFPGVKALDNVSFDLKRGEILALIGENGAGKSTLMKILSGVYRQNEGKIILEGNEVRIEGPSDSIERGIAVIYQELNLSEDLTVAENIYLGREMSSWWNLNRRGLRRRAEKLLSSLNFPVRAGAIVRKLNVSERQLVEIARAMASDAKIIVMDEPTATITEHETSILFKLMRELKEKGVSIVFVSHKLEEVFEIADRVTILRDGSLISSAPIGDYTGDRLIKDMVGRRIDDMFPKENFVTEETVFAVDGLSAPGHFENVSFEVKRGEILGIAGLVGSGKGAIALAIYGGIKATANKAELCGKSFPFPIRPDQALSRGVILIPEDRKTQGLVTSLSITKNIVLPNTELVSKLGNISWRASRKLAEKMINRLAIKTPSSDERVNNLSGGNQQKVVLAKGLTKSPEIVVFVEPTRGIDVGAKVEVYRLMNELANQGKGIIMISSELPEVTSMSDRVLVMHRGRQVAIFERKDINQQNIISAAMGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F715</accession>
    <name>I2F715_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731495.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07718">
        <property type="protein sequence ID" value="AFK07718"/>
        <property type="gene ID" value="Theba_2083"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2083"/>
    <dbReference type="HOGENOM" id="CLU_2356469_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="96" mass="10415" checksum="4AE7E252654F6809" modified="2012-07-11" version="1">MGQNERSGGGGNEDEDNEFLSYFLGHLVFHNSYISGASIVKEEIIIGRSGDDFEYMAGFGVPKDRPFKALSSGDSIIVSIAIDDSIGESRLQTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F737</accession>
    <name>I2F737_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487856.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2106"/>
    <dbReference type="EnsemblBacteria" id="AFK07740">
        <property type="protein sequence ID" value="AFK07740"/>
        <property type="gene ID" value="Theba_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2106"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065773_0_0_0"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028991">
        <property type="entry name" value="KamE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036843">
        <property type="entry name" value="KamE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16554">
        <property type="entry name" value="OAM_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117778">
        <property type="entry name" value="SSF117778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="118"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="258" mass="28549" checksum="BF27CBAB0273314F" modified="2012-07-11" version="1">MDNCSEKKNQFPSEIDLTRVIPYGDTLNDGKVQLSFTLPVPGGPEADEAAKQMIHKMGLKNPQIVFSKEITIGFTFFVAYGEFSHAIDYTAIRVPKITLEKMSMEEIDRFIEERIKRRIVVVGASTGTDAHTVGIDAIMNMKGFAGHYGLERYRNIDAYNLGSQVQNEELVSKAIELDADAILVSQTVTAKNVHLRNMTSLVELLEAENIRKKIILIAGGARITHELAKELGYDAGFGPGTFAEDVAAFIVHKLESMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F749</accession>
    <name>I2F749_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487841.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2118"/>
    <dbReference type="EnsemblBacteria" id="AFK07752">
        <property type="protein sequence ID" value="AFK07752"/>
        <property type="gene ID" value="Theba_2118"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2118"/>
    <dbReference type="eggNOG" id="COG5561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147304_3_0_0"/>
    <dbReference type="OrthoDB" id="1563476at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014925">
        <property type="entry name" value="CGGC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08821">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01078">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CGGC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="147" mass="16521" checksum="DF1133349CC112D1" modified="2012-07-11" version="1">MKKIGIIICGRYQNCGGGKCLRAMREHVGGFALYPKDEELQLVGYSYCGGCPGGNVEYVPQEMIKNGAEVIHLATGMVVGYPPCPRLSHFKEFIESYYEVPVVIGTHPIPMKYLIAHQKLSFWEKTDMFSIAEHLMKEDPAIMKAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7A7</accession>
    <name>I2F7A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731575.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2177"/>
    <dbReference type="EnsemblBacteria" id="AFK07810">
        <property type="protein sequence ID" value="AFK07810"/>
        <property type="gene ID" value="Theba_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2177"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302251_0_0_0"/>
    <dbReference type="OrthoDB" id="462558at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="922"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="969"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="42"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="343"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="905"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110573" checksum="40FD969543C47329" modified="2012-07-11" version="1">MIIQIISLFAGVAVIAILVSMIRNPIIFKIGYRNIYRRKSDTFLVIMGSLIGTALIMGSMAMNDSFQNFLYGQIERTHGEIDELIYIPSDNQNIGKELIPNSKIEILVDSLLKNEQVDGVLPILSRTVSIGLPGEARSQTGKSFQVSMIGVEADQLSNWPDVDKVDLVLPSATDELPEVVINKELAEVAGVAVGDTLEILVDPGQRLLFWIPLPEVRVAEIVEGNGILHYQIENQGSNGFTMLMDVEEAREVLKIGVEDYYNALIVSNRGDFLTGERLTDQVVASIKPLVGEEVVVREVKKDSLSMVDQGNIGLLFLMLSVFAIFAGVLLLTNIYLMLAQERRTELGTLRAIGYSRKRVSRTILYEGFFYSIFSSGIGVLAGLGIARFILGSFVNLFEDAVSLIPFEGANIAFNSMQNSFVFFVRIDSIAYGFLLGLIIPMIIIVYTGRKISRTNIVTAVRNIPEELDERKRLLLNVIAAVGVLVSVVMAYSGYSLGNATGFFTGVMLAGLLIPVAIPMKNKRWIESFFSIAVIVFTMFSNSFDLIASNSGSSIYLTIAKGAAILFAGLFLIVYNLKTFEYLLNKLFQKARAAAPVFKISIAFSARNRLRTGLTIAMFAVVIFVITLISIIPYSMEQMLVKSRDAIFAGFDVGAFSFTGESAITLTELKSQLEVREISTVSGINVALRRDGRYDVEQVFALDDNFIDYNRMTELDFVEGLGISDVKDLWNYLRDNSGTVIVSNSVLPDVRPGDVLELRRIADQSDTGNGAAAFTQKKLSSEMIDSGPIYLEVIATIPENTISFLNGLLIYIGNTPAELTGSSAARHFLFNLSGDTEVEKKANFDSLQDKISSRSPFLLYVDDIMNLTSTMLQGTISILRSFLYFGMLVGIVGIAIIMFKALHERKRIIGMLKAIGFTKAMVFSSFLLETSFIAIIGILLGMVTGTLTSVEIFASPLMEGMKLYIPWDQLISMALIFYIASLVSTIIPSYSASKIAPAEALRYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7F7</accession>
    <name>I2F7F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731619.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2230"/>
    <dbReference type="EnsemblBacteria" id="AFK07860">
        <property type="protein sequence ID" value="AFK07860"/>
        <property type="gene ID" value="Theba_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2230"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="261"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="507" mass="56577" checksum="252B1840C7B5FF51" modified="2012-07-11" version="1">MYLIGCDIGTQGTKSVLVNERGEVLLEAQREYDVIKPGSNWAEQWPDVWAKAAFDTIREVAEKADVTKKEIAGLAISGLYGGSGIPVDREMKPLHPCLIWMDRRATAQTSWVKENIPEEKIFSITGNYVDSYYGFTKIMWLRDNRPEVWKKTYEFVTPKDYVVYLLTGEDAIDYSSAGNIGGVFDIRKLTWSREMCEALGIPMELLPERIVKSSDIVGRVTAESSKLCGLLEGTPVVSGGIDAPVAQLSAGALEEGEHVAMVGTSTCWGTVHDGKEMPFGLVSFPYVVHDTERIYSFGGSATTGALAKWFKDEFADSEESVGKRTGTSPYQLLDREVEKIPAGSDGLIVLPYFMGERSPIWDPFAKGVFFGVTLVHTRAHMYKALMEGAAYALRHNMENGIKAGLKLDDECWIVGGVAKSTVWNKIFADITGYKMRQVSSLVEAPFGDAFLAGLGVGLIDKPERIKDWVKFRDPISPDPNHREIYEKQYSLFRELYEKTKETMWKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I0</accession>
    <name>I2F7I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731642.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2254"/>
    <dbReference type="EnsemblBacteria" id="AFK07883">
        <property type="protein sequence ID" value="AFK07883"/>
        <property type="gene ID" value="Theba_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2254"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="263"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="516" mass="57429" checksum="A56914F52D0140BF" modified="2012-07-11" version="1">MIALNKDTVGPRLILEVKEISKSFPGVQALDRVDMDVREGEVHALLGENGSGKSTLTKCIVGAYQKDSGTILYDGKETSFSSPTESFRQGISVIYQERSLIPKFTVEQNIFLGDEMQVSGLLSEKNMRKRFRSLCESYGFDLSPDEKIFRLGVAQQKVVEIMKALSRNSRVVIMDEPTASLSKEESDHLFKIISQLKSKGISILYITHILEEVFRITDRITVLRDGRKVSTLNTAETDREEIVNLMVGEVFHDIEDISSSANYDLPPVISVKNIQKLPRVRDISFEVYPGEVLGITGLTGSGKTELARAIFGAEKADSGEIIVEGKRVNLSSPVDAINAGIALIPEDRKSDGLIMLFEVFKNITLPSISDFTAMPGMILTKREYVKANEYRERLNIRLASIHQQTKFLSGGNQQKVVIAKWLLTNPKLLVMDEATQGIDVKAKSEIYSIVRELAENGFSVIFISSEVPEVRRVSDRILVIADGEVVGEFKRGARQDEILKKALSGKQEHLDNQVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7L7</accession>
    <name>I2F7L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731675.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2292"/>
    <dbReference type="EnsemblBacteria" id="AFK07920">
        <property type="protein sequence ID" value="AFK07920"/>
        <property type="gene ID" value="Theba_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2292"/>
    <dbReference type="eggNOG" id="ENOG5032U7Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037395_0_0_0"/>
    <dbReference type="OrthoDB" id="1095359at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="277" mass="32086" checksum="48968106136F22CE" modified="2012-07-11" version="1">MLDKNPLMIDIDVKQWANLHHVVLKGLREKRRIVVIHENGKVQNISHSHEVEVVNPIRKVTDPEMDAKKLFETNEKNVDLVMVLERSHVENYYNEVQSSWKVDEDLDEYMYRMYSLLDCYYPGIVAYPGPASRQFGLQWLLPGKVGYLQFKSVLESFADRGTAVVIAVFENKTELWTSLVLGVDEKGKVSLITSVKQGIVKKDWREEYQDINRWVDENYWKSGLAIYMDKKDFLEISSSKAPSYLFKGLCDKGSIIIDPSTESLKAFIAKYRLHELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7M9</accession>
    <name>I2F7M9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ORF">Theba_2305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731687.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2305"/>
    <dbReference type="EnsemblBacteria" id="AFK07932">
        <property type="protein sequence ID" value="AFK07932"/>
        <property type="gene ID" value="Theba_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2305"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09722">
        <property type="entry name" value="Cas1_I-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="329" mass="38826" checksum="9FBA0D143BD59EE0" modified="2012-07-11" version="1">MKRMLYLFTSGKLLRMNNTLVFEKEDGKKVHLPVEQTDSICAFGEIDLNKRVLEFLTQKQIPLHFFNRYDYYSGTYYPREHLNSGFLILQQANFYNDGKKRTDLAKRFVRGSMQNMLSVLSYYNRRGKDLEREIEGLNALKERLEDTGTIDEAMAIEGNFRDLYYKCFDTIIDDSSFEFVSRTRQPPLNRLNALISFGNTMLYTTVLGEIYRTHLDPRIGYLHTTNFRSFSLNLDVAEVFKPILVDRLIFAMINKKQIQAKHFAKHLEGIYMNDSGKEIFVRAYDEKLKTTIKHPGLKRSVSYRYLIRLELYKIEKQITGERGYIPWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7N8</accession>
    <name>I2F7N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731696.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07941">
        <property type="protein sequence ID" value="AFK07941"/>
        <property type="gene ID" value="Theba_2314"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2314"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_0"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="125" mass="14394" checksum="B80D5B8AF0133745" modified="2012-07-11" version="1">MFGNFRKLQLWKSSMNLTTEIYRLTRNFPEHERYGLSSQMQRASVSIPSNIAEGFGRESTKELLRFLYTARGSLMELSTQLEICNNLGYLSEEEHPSIQRLADEVNRLLNGLIFSKKKLRSSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P9</accession>
    <name>I2F7P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator with C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487492.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2326"/>
    <dbReference type="EnsemblBacteria" id="AFK07952">
        <property type="protein sequence ID" value="AFK07952"/>
        <property type="gene ID" value="Theba_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2326"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1883300_0_0_0"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="135" mass="15145" checksum="3D0C1E23CFCA1A78" modified="2012-07-11" version="1">MANKRSSSFGEFLDQIAKTYNVEDSLAIGRIKGQVASQLMSYRKERGLSQKQLGELLGFKQPYVSNIERGEENLSLETLVKISACLKGRLNVDLGITDRKTKITKEVIKYVPIYIPVISVQNNESSFCWKPSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S2</accession>
    <name>I2F7S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731723.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07975">
        <property type="protein sequence ID" value="AFK07975"/>
        <property type="gene ID" value="Theba_2350"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2350"/>
    <dbReference type="eggNOG" id="COG0833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_13_0"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="458" mass="50111" checksum="C4BCFDEF39488F53" modified="2012-07-11" version="1" precursor="true">MPSNLARKVSQMKKSLKFWDLVALEVGMTIGAGIFVYMPIAYKSAGIGTIVAFIFAFLPMAIIMINVMLLGSTLPTTGGTFKYGAFLFSPKVAFLGLWAYLFGAFVGLFPLNALALASYMKGIWNGISVVPVALIILTFFYVVNLLGLKTASIVEIVFVALLFVAIAIYTVPGVAKIDPRNLEGLFSTGLGPMIYASALLTFTFAGSNAVIELGGEVENPRKNLPLSVMLSLSIVLICYLLMAIVSFGVGEEVMANGTLNDVASNYLSGFLFYVFAFGGPILAIATTINATYMWGTRSLLALCKLRVFPSKLGLVNKRGTPWVLLTIIWLLSSIMLISVGESGLNLFAAFASIGGIAVIIPTMFAVFKLKKNETLRKTAPAIVKKKWFIFIPILGVVFSILIMLILLYQVGVDFSTSFFLFFIVWEVIGMIYFIFRLKYLDRTEKNVFSRNDLSVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z3</accession>
    <name>I2F7Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731784.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2431"/>
    <dbReference type="EnsemblBacteria" id="AFK08046">
        <property type="protein sequence ID" value="AFK08046"/>
        <property type="gene ID" value="Theba_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2431"/>
    <dbReference type="eggNOG" id="COG3876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033227_1_0_0"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="373" mass="42750" checksum="06D8EECADF8B1CA3" modified="2012-07-11" version="1">MILLGIDQLQKNGLIGLKKKAIGLVTNFSFVDSDLKWGIDILFENGLNVKKIFTPEHGLGGVADGAHVSDTLHPKYGVPIVSLYGDKRKPVKEDLDGLDMLVYDIQDVGLRFYTYIYTLAYTMEAAAEYGLQYMVLDRPNPLGRGVFGSRIENDLQTFVGGYELPLQYGLTTGELAQYFKKLKRLDLDLKISMLEGWRGEMHDNTSLFWNVPSPNVPTFESLLGYAGTCFFESTSVSEGRGTFKPFLVIGAPWIDGSDLTKYLREEFPGLRVRSRDYMPFYRKYANANCSGVEFFPRIEDNYFVITLKMMEYLLKYEQFDIMDRSDDLIGIKESALKIRTHNLDYREWNESGMEFIDFVDDCLLYPGELKYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F845</accession>
    <name>I2F845_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731830.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2487"/>
    <dbReference type="EnsemblBacteria" id="AFK08098">
        <property type="protein sequence ID" value="AFK08098"/>
        <property type="gene ID" value="Theba_2487"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2487"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395770_0_0_0"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="702" mass="79528" checksum="864E3C7A64354DD0" modified="2012-07-11" version="1">MKKENWSKICGTPRLISAEIHYFRLEPGEWRERIEKAKEAGCDAIASYIPWLCHESVEGRYDFTGRLDLRAFVELAKDLGLYFIARPGPFVMAELKNEGIPHWLYDKHPHLRPLSWEGRKVESAMVIYNHPDFLAEVEKWYDRVGEILGPLLVGRGGNVVAVQLDNEIGMLQWVNNTPDLSDFTLARFNDRVSEKRGREPYGFALEKRDETYRLLRSPGEDFSLEFIRDLGQFTREDYREYVQNLKQLAKRAGLEGIPYIVNIHGTSEGRGFTFPIGISQLYKACDDEEVFPSSDIYLGDLSLRNFQDLYTINETLAAACGGVYGSMEFECGDGNYGDNYGQRIDPYSLEHKLKLCIAQGNRLINYYLFSGGRNYVLDPEPLDGNGRIAFTGELHGFAAPISPTGAENYTYGFLKEATLSLKPLTRNMGNLSVSHDPLTVAFIPDYFMSEYRYGTRSGEMISDLQTHRAGNFWDSFLKALLLLGYRYDVKNIQDGEIDPERLLILPCARYLDVAIQRKIADHVERGGRLLIYGEVPLFDMTGRVCRELIEALGITPGEAYRSSSKYFLSVKPLGLPELATHFARAFRIEGGEELAVIAQKGETCAARVGSTTVITAHFNCNTGFFGRILEGYGLKPKISMTGDSFGVFPVVSVGDRGERLVYVFNEDNFERRIGLRFEEEPLFGGKELLLRAREVAVEMRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F862</accession>
    <name>I2F862_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="12" type="ORF">Theba_2507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731847.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2507"/>
    <dbReference type="EnsemblBacteria" id="AFK08115">
        <property type="protein sequence ID" value="AFK08115"/>
        <property type="gene ID" value="Theba_2507"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2507"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_3_0"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK08115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="235" mass="26518" checksum="BDB7230B90024F1D" modified="2012-07-11" version="1">MENRSCFSLRLDGLTKYLEGLNLQNLALEKVMSGKADCILILLEHEPVLTVGKSGGRENLLVDESELERLGVELQSTGRGGNITYHGPGQVVAYPVLNLGKWKKDLPWYVHSLEEVVIRVLEDYGIEAGRKPEYRGVWVKETKIAAVGIAVKRWFTMHGFALNVRVNKEHFKLINPCGIKDYTIASMDDFVDSVDLHEIIKSVEEKFSLVFKSKLIEVSREWLESGQSEGETRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F871</accession>
    <name>I2F871_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731855.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2518"/>
    <dbReference type="EnsemblBacteria" id="AFK08124">
        <property type="protein sequence ID" value="AFK08124"/>
        <property type="gene ID" value="Theba_2518"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2518"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="258"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="452" mass="49247" checksum="24B16A2BB4EBC7FE" modified="2012-07-11" version="1">MNSSVLFAGYDIGTTSSKVSILNAEGHIISNAKVNHPQEFSIDGFPEQDAQNWWEDFKKLTSIVGKEISLSRTEAIGLSSMCPCVLPVSDEGIPLRKSLMYGIDQRASKEVELLNESFSREKNRSIYTDYSSQSILPKLLWLRENQPAIFKSTSRILTANGYIGSKLTQSFVMDYFSASAGNLIDLNSLELFEEPFDRFDLSTSLFPEIRWALEPIGSLTRSASLETGLKEGITIFTGTGDACADAITNACIEPGSVSVSLGGTSIFIQSLEKPVWSPDLFVETGATPGSFTIGGATSCGGLLTDWIVERLFGLKASEKEVLLRDFDVKKYRPSNLILLPFFGGARTPFNDPGAKGIFFGLSMEADRENILSALFESIAIDIGMISDEIKRTALEPGQICVSGGGTRSEVLLGLIATALDRELLVCPQEYDSASGAGLIALWRFRNRASRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H5</accession>
    <name>I2F8H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="6" type="ORF">Theba_2628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731935.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2628"/>
    <dbReference type="EnsemblBacteria" id="AFK08228">
        <property type="protein sequence ID" value="AFK08228"/>
        <property type="gene ID" value="Theba_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2628"/>
    <dbReference type="eggNOG" id="COG0214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_0"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="292" mass="31602" checksum="C7FB0E19AB373D1F" modified="2012-07-11" version="1">MEARGTWTVKKGFAEMFKNGVIMDVTNPEQAKIAQDAGATAVMALERVPADIRKEGGVARMAKIGLIKEIMETVTIPVMAKARIGHIAEAKILEAIGVDFIDESEVLTPADDKYHIDKRIFTVPFVCGARNLGEAVRRIAEGAAMIRTKGEAGTGNIIEAVKHMRTVNEEVRKVQMMNDAELVHYGKEIGAPVEILSQVRELGRLPVVNFAAGGVATPADAALMMMLGCDGVFVGSGIFKSKDPARMAKAIVEAVLHYDNPKALAEISENVGDAMDGLEIETLEVRMEERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8M4</accession>
    <name>I2F8M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="5">3.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_2678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate</text>
            <dbReference type="Rhea" id="RHEA:22608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="3.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731972.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2678"/>
    <dbReference type="EnsemblBacteria" id="AFK08277">
        <property type="protein sequence ID" value="AFK08277"/>
        <property type="gene ID" value="Theba_2678"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2678"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_0"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="172"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="367" mass="40404" checksum="A1012569A6CFA330" modified="2012-07-11" version="1">MKLSDKELEKLLLELCSANTTNPPGNEDRAVEILQRVLVDRNVHIEIQKVAENRSNLVARLQRDPALPYLLLSGHMDVVPAGSNWDSDPFKPKLVDGKLFARGSADMKGGLSALTAALIDLSEDSDFSWNVALIATCDEEVGCSGIRHFLEHQTFDVSGVIIGEPTSLRLATGEKGAIWLKLKFRGKSAHGSQPQNGINAVTKLFSAYTELSQVLGKIEGLTESLNIIRGGSKENTVPDEAECVIDIRFAENTDSAEIIALVDSVLSKYNQSERIILLNRESFSSSGNLTESVKEVLKEKAMNAEELTMTYFTDGAFTASQGIETVILGPGSPSMAHRSNEYVELEEVHMARRLYSKIARNYFERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1F8</accession>
    <name>I2F1F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729944.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0006"/>
    <dbReference type="EnsemblBacteria" id="AFK05761">
        <property type="protein sequence ID" value="AFK05761"/>
        <property type="gene ID" value="Theba_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0006"/>
    <dbReference type="eggNOG" id="COG3234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865401_0_0_0"/>
    <dbReference type="OrthoDB" id="1378174at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009558">
        <property type="entry name" value="DUF1175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06672">
        <property type="entry name" value="DUF1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="328" mass="37836" checksum="436E893220C84F40" modified="2012-07-11" version="1" precursor="true">MRMNIAYLFLVILTTVVLSATFLNFKDDYSNIRVQTSDVRRGESFSISVPKSTYERSTLSYVRGATLESFYSDSDLVTYSFCADDKNAVIVVDFKGLFRASKTISLEFNDFVDSNSDGFPDKLVLDYEDAENFRAWFVNIAAYQVIEFSNNWKSEERDCSGLIRFAAREALKTHDEGWFSETAVDYDLWREKTGIDLRKIPDVREYNYPDIPILRNRIFISNDGAFTYFADAYNLVRSSMVFKGRDLGAARPGDIIFFHHPSPSTFHSMIFTGDGLIYHTGPLSETDSGVLKLWSMDDYVRTMPYQWQPIYTNENYLGVYAFKFLPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1I5</accession>
    <name>I2F1I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopolysaccharide biosynthesis protein, WecB/TagA/CpsF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729965.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0034"/>
    <dbReference type="EnsemblBacteria" id="AFK05788">
        <property type="protein sequence ID" value="AFK05788"/>
        <property type="gene ID" value="Theba_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0034"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_3_1_0"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="246" mass="27923" checksum="C321F084BF32404D" modified="2012-07-11" version="1">MRFLDFELEEKDLVSVANELIQRTQSGVRSHVLTINALIAYEYMHNEEYCRALHKVNYVVPDGSGVLKAIKLISKRNLERVPGIDLMLKLCELSAEKGLSIFLLGSKETVVTKTTEKLKQRFPLIDIVGYHSGFFTQEENDTIVSEINASSADILFVGMGVPRQELWIAENAEKLQAKILMGVGGSFDVVSGNLKRAPLWMQRAGLEWLYRVVREPGKRLKIIPKLFSFETYVIRSYLESRRGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1W5</accession>
    <name>I2F1W5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730082.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0178"/>
    <dbReference type="EnsemblBacteria" id="AFK05918">
        <property type="protein sequence ID" value="AFK05918"/>
        <property type="gene ID" value="Theba_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0178"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_0"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="116" mass="13058" checksum="43C1BB7984AF8A04" modified="2012-07-11" version="1">MNRELPLRGEIWLANLSPTRGREQSGFRPCLVISVDQFNHGPAELVIVVPLTSKNKSIPLHVEISGEQTGLDVTSYIKTEDLRSISRNRLEKKIGQVSEEVILDVLDRIKILLDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y3</accession>
    <name>I2F1Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-serine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730099.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0201"/>
    <dbReference type="EnsemblBacteria" id="AFK05936">
        <property type="protein sequence ID" value="AFK05936"/>
        <property type="gene ID" value="Theba_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0201"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_2_0_0"/>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="1">
        <location>
            <begin position="41"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="293" mass="30932" checksum="01886B078A880927" modified="2012-07-11" version="1">MIMKFEDLVKAARDSKTPLHKVVSDWYMMSTGNDPKVAEDTAKELIGEMMSSYHSRLEKPEKSLTGWVGDNDEKARNHAPEFLSPLVYSGVGVALSMSEHNASMGKIVACPTAGACGVVPGALLSLHFNRNIDLETLGNALLVSGAVGERIRKRASISGAVSGCQAEIGTATAMASVAIVYATHPEEYSALENAPALALKSLMGLVCDPVGGFVEIPCVKRNAFGVSIAFTAAELALAGIKSAIPFEEVADSLGRVGRRLPEELKETARGGIAITPTAKKMVADFLSGVDRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F211</accession>
    <name>I2F211_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730126.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0230"/>
    <dbReference type="EnsemblBacteria" id="AFK05964">
        <property type="protein sequence ID" value="AFK05964"/>
        <property type="gene ID" value="Theba_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0230"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252568_0_0_0"/>
    <dbReference type="OrthoDB" id="468923at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1429" mass="155871" checksum="A21E5AA23848DB68" modified="2012-07-11" version="1" precursor="true">MAKKLLKLTTLLAILLLVFMLTGCPKPPVEYTLTIEKTGSGDGTVNADPEPNTSGKYTAGTDVTLTAEADAGSQFVKWIIGETEETGNPLVVKMDADKTVEAVFEEVTGVQFTLTVAKAGDGDGTVTPPVGPHEYDEGKVVTLIAEADENSVFDKWVVDGVEFEDATVIATMTKDILATAHFDPKPDVLPEIILEWTLGDLMVLGAPCAAPEDGLGFQYLVGDSDSSLTEASWSIVKGEEVVYGPIAIPSSRFYNSWTGAITAAMLGADPVGGIYSLTMTATKTGGISKTEKIDFYVHTDEAAIDGVDFAGEIVLFEGTAILTGDEATLEATITLDSKVRVRIYAYEGEWDCECVDNALLYDGFLTREASSTEKETFELDLTKLKSGVNYDKLRIIVYNEICGTMPCNYCPDDEKDIDLVFDKTVTLDCEPCTCAPCTPCWNGEFNPGVRIMNLLFKDSDFFDVSATINGETIPATLIEAPVEDGDDLVIRAIIREEDFPELAGDALLIWTVTTVTGQSVVVECDEDFDFIPPEVDILLECDCDATTTVVPILFTDEAGLKEANVWFGESVSGLIKKVTFDATPTGESTTTFTSGFTSGWEFPATGMIYDVIATIELDPAKIVSPTLGGSYTVYADAEDTSCNISDVAMETCAIDFVAPTITYFGLDCVGTDCDLCEATQTTLVWHIRDVNFDYAEISVNYGNLCSDGQCGNTFITESKDGTVLWEFPFADCREITATIKAVDDCENESSKTIKFDVDNVPPELDLEWCVEPETCDATFARFSWTMDDPCTPTVYFDTWIPIGELDYVVMENGKEVLYPYTPDGTTTKSGIIQWSWENCFFDCTELTIFAEAVDFRCENSTEASLTTDVALDFLPPEAHLFLGESQAKYAWEAYENETNIGSPDCDATCLWVNWIVFEDCLESIEIWSNYPSVCETGGTGEYLEDEYLLFAWPEMNAPTGSGWRWYSCGDENETAATIQAAEGLDGDNGFGYYYPAKYYWGSIKVCLPSNLDCEDFVATITAVQTCKPDIDEPETYTSVDDDNALIDRKAPEILTFDWLTVPTACATEATVTIEAYDGSFIGKSSVDAYIEGEMVYEDGEVVPFGGETVLLTIDPVTGIATGTYWNTYDQINCATIVATLTVGDICCDGVDPNLSVQRLEIDIDNVKPNVNDFYFASEANSSDELSDVSGDGWTMDVDETTHASLTACGTDFVYLYWDADDITGDSTGCYAGVEILMEHGDGTVDVFESPAATGTVKWEFGEVAGDTLLATITAQQENGCLESDPATVSAYVSNVGPQFVALRFQVPYDPPLAPPVLGTIWVDFNVPIDTSEATANIWRWDDLSETWMLETYVDGNPWIWDKGITGDDNVDLKRAQLVNVDGTIGYPIVLDGLYKLELYSIKSVAGACEGIYIDPLVRTGTGRITAPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F218</accession>
    <name>I2F218_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ORF">Theba_0237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730133.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0237"/>
    <dbReference type="EnsemblBacteria" id="AFK05971">
        <property type="protein sequence ID" value="AFK05971"/>
        <property type="gene ID" value="Theba_0237"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0237"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_0"/>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="332" mass="35426" checksum="A70FF14065097CFA" modified="2012-07-11" version="1">MQSIRIALDAFGGDNAPQVNVDGAFLALKEFQDLEILLVGREEDLKPLIKESPETSRISIVDAREVFPMSEKPSLLLRKKETSLYKAAIQVKDANADALVSAGNTGGVLAAALFVVGRIKGVDRGAIAVLVPSKNGFTILIDAGANAEARAEHLRDFGTMGYEYAKLLGREKPKVGLLNVGEEQEKGTELTKLAFDYLKNDLGDSFAGNVEGRDINYGDVDVVVCSGFDGNIAMKTMEGTGKLISATLKKEIKKSGLFGIIGALFLKRALGRLKKTMDPSEYGGAFILGVKGAVVKAHGNSNALAIKNAIRVAYQGVKGDLIKKLEEKLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F221</accession>
    <name>I2F221_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491693.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0240"/>
    <dbReference type="EnsemblBacteria" id="AFK05974">
        <property type="protein sequence ID" value="AFK05974"/>
        <property type="gene ID" value="Theba_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0240"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK05974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="229" mass="25859" checksum="59A4B2CFC251E534" modified="2012-07-11" version="1">MHLRISSLSKAFDGETIVDKFSYSVEGDFFLTILGSSGCGKTTLLRMISGILKPDAGRVELQSERLGFVFQDDRLIPWLNAFQNISIVSPKSSPVEYLSFVGLKGHENKFPSQLSGGMRRRLNIARALAFNPDLILMDEPFNSLDVVIKDRLIEDIQKLWTGRKISIIMVTHDPSEAARLSTDIILVQDRFSKVDEIKLGDPLERSPDDIDLISRDLLSRMKKFSSYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F241</accession>
    <name>I2F241_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein A (IM30), suppresses sigma54-dependent transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730152.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0260"/>
    <dbReference type="EnsemblBacteria" id="AFK05994">
        <property type="protein sequence ID" value="AFK05994"/>
        <property type="gene ID" value="Theba_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0260"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056466_4_1_0"/>
    <dbReference type="OrthoDB" id="941029at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="129"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="225" mass="24805" checksum="A78B02C698401ED9" modified="2012-07-11" version="1">MGILDRFNDIIKSNVNSLLDKMEDPSKMIDQHLRELSEDLAEVKRGTAGVIAEETRTKRLVDENAAEVAKYADFAKRALLAKNDGDAKVFIAKKQELENVGAGLMTAYAAAHENAVKMRQMHDKLVSDIESLKNRRAMIKAKVAVAKTQKKINEVSSSAGKTQGAIDAVGRLEEKAQKMLDEANAMAELNTEPIDKAKALEEKYAAKSSFAVDEELEQMKKELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F258</accession>
    <name>I2F258_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">Theba_0279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730167.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0279"/>
    <dbReference type="EnsemblBacteria" id="AFK06011">
        <property type="protein sequence ID" value="AFK06011"/>
        <property type="gene ID" value="Theba_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0279"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_0"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="47169" checksum="96B615771C897EEE" modified="2012-07-11" version="1">MWESLEKTDKQVFDIMFKELERQRNGLELIASENFVSRAVMEAMGSVMTNKYAEGYPSRRYYGGCVFVDEVEDLARERAKKLFDAGFVNVQPHSGSQANMAAYLAVAKPGDTIMGMSLSHGGHLTHGSPVNFSGKLFNAVSYGVNEETEVIDYDEVRKVALDAKPSVIVAGGSAYSRIIDFKKFRDIADEVHAVLMVDMAHFAGLVAAGLYPNPLDFAHVVTTTTHKTLRGPRGGMILTNNEEIAKSVDKMVFPGTQGGPLMHVIASKAVSFGEALRDEFKAYQQNIIYNTRRLAKSLEEKGLRIVSGGTDTHLFLVDLNPMNVTGKAAEKALEKADITVNKNTIPKETRSPFVTSGIRIGTPAITTRGMTEKEMPLIADLIIRVLENIEGEKGEISQTKVREISEEVKTLTSKFPLYSDLIHRSDAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F265</accession>
    <name>I2F265_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ORF">Theba_0286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730171.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0286"/>
    <dbReference type="EnsemblBacteria" id="AFK06018">
        <property type="protein sequence ID" value="AFK06018"/>
        <property type="gene ID" value="Theba_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0286"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_2_0"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="185" mass="21490" checksum="E22E1D4604ED4780" modified="2012-07-11" version="1">MSELKDKSLEEMVPIGRIVKPHGLRGEMKVKVALEDETAFKEIQEVLLYDEKTRSRFVTSIDGARRATKGWILHFEGIDSMGQAERLVGFHIYVEERVLPELKQGEYYYFQILGSSVFDENRRFIGTVNDIIETGANDVMVVVREEDLTVREELIPIIRDYILELNFEDKTIVARSMEFEEVKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>I2F294</accession>
    <name>I2F294_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="11" type="ORF">Theba_0317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730189.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
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        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
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        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
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        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
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        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
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    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="10">
        <location>
            <begin position="336"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK06047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="397" mass="45390" checksum="0E4104D685E74417" modified="2012-07-11" version="1">MTPEEQLKELSRNHVSLISEEELLRKLKSKRSLRVKLGVDPSRPDLHLGHAVVLRKLRHFQKFGHQVVLIIGDFTARIGDPSGRSKTRPMLSREEAKINAESYSTQAFKILDRELTEIRFNSEWLDAMSFEDVIRLSSKYTVARMMERHDFARRYEENEPIGISEFLYPLAQAYDSVVVKADVEIGGDDQFFNLVVGRKIQEEHGLEAQAILTVPLIEGTDGKLKMSKSYDNYIAFDDTPRDMFGKLMSIPDTLTLKYFRLLTDKSEVELSEIETKIKSKSVNPRDLKLELGVEITSQFYGEETALNARDEFIKIFRNKELPGEIPEIKISTESVSVVDLLVSHANISSRSEARRLIDQGGVKVNDEVLNDIHSVIEISDGDVLRIGKKRFYRLVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2C5</accession>
    <name>I2F2C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BirA, biotin-(Acetyl-CoA-carboxylase) ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="AFK06078"/>
        <property type="gene ID" value="Theba_0349"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="267" mass="30063" checksum="213A4C8EC4B18F9F" modified="2012-07-11" version="1">MLLKGQRRFDVFRQIHSDFEDEIPTMMVGENIVSFSEIDSTNVYAKNNLDKLPSGTVVWALSQTSGYGRHNSFWYSNKGGLWFSIVFKPSLIREPNEYTKVVSVAVAETMIKMGINSVGIKWPNDVLIGKRKVAGILTEAIFSGISVNAIVVGVGINVNNELPEEIRQIAISLGMVINKHISLEMLLDKVLKRVEFLRKNYLIRGKNRYLTRRWKKYLAFAEKDEITVSLPNGEKITGIINSITPSSLCLEREDGVILEINSGEILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2E3</accession>
    <name>I2F2E3_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06096.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFK06096"/>
        <property type="gene ID" value="Theba_0367"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5032RQK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114103_0_0_0"/>
    <dbReference type="OrthoDB" id="2010192at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025529">
        <property type="entry name" value="DUF4416"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14385">
        <property type="entry name" value="DUF4416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="178" mass="21176" checksum="DE168E3AFA63F320" modified="2012-07-11" version="1">MGNYRKTEMVNLVIFVFGSYIDYRLQEIQPVLEKRFGPADYISKALDFDRYTSYYNDEMGYGLRGKLISFKRLIHPQQISLIKRLTNAIEDHFTLEGNRKVNLDPGYIHHAQFVLASTKHWANRVYVGDGIYAEITLMYIDGSLKPLPYTYPNYKDREYIEELMKIRELYLLKRKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2L1</accession>
    <name>I2F2L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730279.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0437"/>
    <dbReference type="EnsemblBacteria" id="AFK06164">
        <property type="protein sequence ID" value="AFK06164"/>
        <property type="gene ID" value="Theba_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0437"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_1_0"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658620" evidence="1">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="422" mass="46247" checksum="3A5EA259E49AD2AE" modified="2012-07-11" version="1" precursor="true">MKKVLLTLMVALFALVAVSETVITVAAGAVGQELELTKKAAEMYMEIHPDVTVKVLDTPDMVQDRLGLYLQFLEAKSPEIDVYQVDVIWPGDLAQHFVDLYEHNADKVVSMHFPAIIENNTVDGKLVAIPWFTDAGLLYYRTDLLEKYGLNPPATWDELEEAARIIQEGERKTNPDFWGFVWQGNAYEGLTCDALEWLASNDAGTIISSDKKITIANSNAVEILEKVAGWVGTISPSGVLTFAEEDARAVWQAGNAAFMRNWPYAYSLSKGEDSAVAGKFDVSPLPAGKSGNGAATLGGWQLSVSKYSKNPEVAADFALFMAGYEVQKMRAVEGSFNPTIQALYADYEVLKANPFFGSLYDVFVNAVARPSTATAPRYNEVSTLFFKAVHSILSGTADARNALEELALDLEDMTGFEVVWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2M2</accession>
    <name>I2F2M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730290.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0448"/>
    <dbReference type="EnsemblBacteria" id="AFK06175">
        <property type="protein sequence ID" value="AFK06175"/>
        <property type="gene ID" value="Theba_0448"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0448"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_0"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="317" mass="35063" checksum="017C2A60165913F2" modified="2012-07-11" version="1" precursor="true">MEFGYVIRRLLSAVPTVLLVTFMVFIAIHIVPGDVIDIMLGTQNYLTESQIEDLYSEYGLDKPLIVQYGIWVKNLLSFNLGTSLRTGRPVTELIKERFPVTLELAAFSLGFALLFGIPMGIISAIKRNGFLDNFVRVIGLIGLSSPSFWVGAILIVLVSGAFDNFNLFGYVSPVVDPFSNLQVMFLPSLTMGLMVAAQILRITRTSMLDVLNQDYVRTARAKGVSARNVILKHSLRNALIPVVTLSGIQLGYLLGGTIVIENMFALPGMGRLLLQVVNERDYPVVQGIVLFIGIIIVMLNILVDVIYTLIDPRVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N5</accession>
    <name>I2F2N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase 24 kD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730302.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0462"/>
    <dbReference type="EnsemblBacteria" id="AFK06188">
        <property type="protein sequence ID" value="AFK06188"/>
        <property type="gene ID" value="Theba_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0462"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="165" mass="18362" checksum="5C1E039C31CCDA32" modified="2012-07-11" version="1">MSAEDVRLTVTRIYEDISGQSLEKGDVLINTLHAIQDHYGNFIPIEAAEVLKELTGTPLSRIYEVLTFYTMFSTHKRGKYVVRVCKSLPCHVTGGQAVIDSLKNTLEIGFGETTEDGLFTLEETSCLGLCGVSPVMMINDEAYGNLTPKRVSEIIREIVSRERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2N8</accession>
    <name>I2F2N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase 24 kD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730305.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0465"/>
    <dbReference type="EnsemblBacteria" id="AFK06191">
        <property type="protein sequence ID" value="AFK06191"/>
        <property type="gene ID" value="Theba_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0465"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
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        <property type="entry name" value="NuoE-like"/>
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        <property type="entry name" value="NuoE_dom"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH_DH_24kDa"/>
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    </dbReference>
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        <property type="entry name" value="SSF52833"/>
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    </dbReference>
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        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="164" mass="18477" checksum="233B024BEF3B3A84" modified="2012-07-11" version="1">MSLVNCPECQQLYKELDEYIDSVKGNTGVLINVLHKAQEIFGYLSEELQQHVSEKLDIPLSQVYGVVTFYNFFSMKPKGKNQIKVCLGTACYVKGADKILERLQDELNVEMNEPTSDGLFSIHAVRCLGACSMAPVVLIGEDDYYGRVSPDEVSKILDKYRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P4</accession>
    <name>I2F2P4_9BACT</name>
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            <fullName evidence="2">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_0471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="Theba_0471"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFK06197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="392" mass="43278" checksum="D18B93F54B58AAB4" modified="2012-07-11" version="1" precursor="true">MKKYFHVFNFYAFSFSILLYLLNSSINTKAAEWGLSYMVIGLINFIGCVFYVISALVFGRMGDRTGFKRSLSIGMFIMTIALFLGFFWSRPVDIVIAAIGVNLFFGFFFPSLEGLLSKSEKSIGIDSASTVVRFVLSWSAGNIVGMAFGPFLIQRFPAAIFSYGIALCGLGSIHVRSHLKRHGESLPGSFAETFSSSFSEIDLPRLEEYRKVYRFTFLLAGIIYTSGMALFPKLISSTGIQLQNVGFLTVGANVGVFLSFVFLSLFRFWVGSPELSFITMITVFGAAVATFFLPESPVTFFLATLFSGATYAVPYIFAIFYGLTSKEDDHGKQGGIHESMVGIIFGVGPLLGGYFLQLWPSLKSVGLMSIGLITVIIISQMTFLFKNNVKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q7</accession>
    <name>I2F2Q7_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Dinuclear metal center protein, YbgI/SA1388 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Theba_0484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
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    <dbReference type="EnsemblBacteria" id="AFK06210">
        <property type="protein sequence ID" value="AFK06210"/>
        <property type="gene ID" value="Theba_0484"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="243" mass="27211" checksum="441664760D1706AB" modified="2012-07-11" version="1">MKPEDIESFLNSVLHPEEFDDYCFNGIQIEGSKEINKVVTGVSFSDALVEKAVTAGADAILVHHGIFGKEFFRLSGYLKKRVERVLSLGITLFGYHLPLDANEPYGNNYSIAEEIGLVNLERYDVGFIGTHPENILVSELRNSLCRIFPRQEVGLFKNSDFAGRVCIISGGSSSNLRELEGTADTFISGEVGEPTREIARETGINFFWVGHYASERFGVINLGELLRERFSLEVEFVEIYNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V0</accession>
    <name>I2F2V0_9BACT</name>
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        <submittedName>
            <fullName evidence="1">DRTGG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0530"/>
    <dbReference type="EnsemblBacteria" id="AFK06253">
        <property type="protein sequence ID" value="AFK06253"/>
        <property type="gene ID" value="Theba_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0530"/>
    <dbReference type="eggNOG" id="COG4109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140224_1_0_0"/>
    <dbReference type="OrthoDB" id="1675913at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="111" mass="12119" checksum="BA45039DD46DA371" modified="2012-07-11" version="1">MKLNDLIEKCEMRVITTLPLDIEISDAYIGDLLSDVMGNAPSNSIWLTVQSHVNILAVASIVGVRAIVLCNGLHFEESTVRKAEETGIVLLESDYTTFDTALKLIKSGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V3</accession>
    <name>I2F2V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein/protective antigen OMA87</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_0533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730363.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0533"/>
    <dbReference type="EnsemblBacteria" id="AFK06256">
        <property type="protein sequence ID" value="AFK06256"/>
        <property type="gene ID" value="Theba_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0533"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_343828_0_0_0"/>
    <dbReference type="OrthoDB" id="696675at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="3">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="823" mass="91466" checksum="737A8EE329222263" modified="2012-07-11" version="1" precursor="true">MSVRRLFLILVLVLVSGSVFAVIVPSRITVLDNRVISDGEVLEILDIQRGKEISDSELSEALERVRNSGYFSDVYYSFDESSGLLKIQVVEYPVVDVEVVFDGPKIVEPDVLESVSVIESGKPADPSTLIYDIPLTQEAMMSKLVENGYIEPFVEVEWETDKSREDVFSGNIKDRVKVTFTVKVSFLWEVSIEAPLSDESKAFLSSKLQIDCLKKYYDTSFLVRWINSKKKYVPKLDDINMMVQTVYSTYYANSSGQWGFDDETYQAMILTLNNALRNARQVTLPEEVKESRALSMSIAFAPVEYVKEEFDLRSVFIEGNVNLQKGEILRETGLTEGQRVDNEVAMRSIQAVQDLYTERGYPFIRIEPVIDEKIGFFSIKITEPLVRDITVEFDGPKKTQDYLIVDKIVIQKGNVLSLDELRNTYAFLNNTGYFSKVDIAPVPVGEDALDVSITLQETDKNNKIGGGGGWQNGLNLYLDLGLLNVWGYGQNISTTLSVTLPMPNNKEVIVTDGATETTTRRPAFDATIGYSVPKVGGTKLDLDTAFKFKFSGFTTTNDSTDTIVTKSSQETEFLFSLTPIYNISPGQKVGFTAGYEYIMSESQVSTETKTATEVDTGSLSENFDGIFTGLSYELSTRDDLYRPTMGSEYLAGLTVRGLFGKDNEPFISGYAEYRNFMSIGDPVLGFRVRTQQLFPLSPNGVFRSYLLTPDTFVRVRGSQSIGQNAYGVTVGSAQLRYPLTPEASSIPLDIVGFGDLLFYRKTPGGDLIGGNFLADFGLCIDISIPMIGLVRLGYGYNTFLAEQNSGAGEPYYGTPFFGFGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2X9</accession>
    <name>I2F2X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein Theba_0559</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730379.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0559"/>
    <dbReference type="EnsemblBacteria" id="AFK06282">
        <property type="protein sequence ID" value="AFK06282"/>
        <property type="gene ID" value="Theba_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0559"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018288_2_0_0"/>
    <dbReference type="OrthoDB" id="229299at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="285"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="580" mass="65880" checksum="482A96739AE54AA6" modified="2012-07-11" version="1">MNIPMTRSDMVERGREYLDVILITGDAFVDHPSFGTAMIARVLESHGWKVGVISQPDWRTNEDISVLGKPALFFGVTSGNVDSMVANYTSTGKKRRSDDYTPGGFGGKRPDRATIVYSNLIRQVFKETLIILGGIEASLRRFSHFDWWSNRIRKSILLDSKADLLVYGMGEKPILEIADKISKKREVPTDVEGTVFWSSSKPAGIELPSHEEVSQDKRKYFEMTKVMHEETDPVRGRQLFQLQDNRYVVQNKPPKVASEELDAYYSLPFTRRVHPVSLSRGRVKALETVRYSVTSHRGCYGQCNFCAIAFHQGRTVVSRSEDSIIQEISAFTRDVGFRGTVTDVGGPTANMYGYECSIKEKVGACAKKRCLFPEVCSSLKLDHSRYLNLLKRIRKIPGVKHVFVSSGIRYDLILKDKRSGRDFLRELLQKNVSGQLKIAPEHTAQKVLEYMGKPSKDVLLDFLKEVRLVSSGKCHIIGYFIAAHPGCTKEDMMELKRFVKREMHYNPEQVQLFTPTPGTISTAMYFTEMASENGDPVFIERSTGGRNRQKEILVRKEILDRKPDKNVEGTGNKRNKRDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y1</accession>
    <name>I2F2Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730381.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0562"/>
    <dbReference type="EnsemblBacteria" id="AFK06284">
        <property type="protein sequence ID" value="AFK06284"/>
        <property type="gene ID" value="Theba_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0562"/>
    <dbReference type="eggNOG" id="ENOG5034895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592435_0_0_0"/>
    <dbReference type="OrthoDB" id="1963863at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="169" mass="18982" checksum="542FF70CDE3E76F1" modified="2012-07-11" version="1" precursor="true">MKIRKFSIIVIVVLITTLFSSCSASKSELVPGKFAGFALSDYMDISTSVSVGGMILGIELNEDTLLLHKEFAKGTKEFNVYVAKFENASRATGFWYDFVREVSNEIRSVISAIPWIYGEFSGEVGESFMKSWFSGRWLYVFLGDNSEEVDSAVRAFKEFEKSLVRSVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F313</accession>
    <name>I2F313_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="8" type="ORF">Theba_0597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492238.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0597"/>
    <dbReference type="EnsemblBacteria" id="AFK06316">
        <property type="protein sequence ID" value="AFK06316"/>
        <property type="gene ID" value="Theba_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0597"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_0"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="354" mass="41345" checksum="2E8668543C457E5B" modified="2012-07-11" version="1">MDRKGIFRKRKPPLGSVPGTLSIDEESPFPKISLIEFDRDYLKEEIIRNVENLASVISATDRVHWIDVQGLGDEATIRKLGEVFSLHPLALEDITNVPQVAKVEEYDNCLFVCLPMMRMEEDSVVYEQMSLFLGETFVLTFQERYGDVLDPVRNRMRRNSRIRSMDNDYTAYAILDTIVDNYFPVLQSIGSELEKLEEELVESISREKLKDLYLMKQKLAQLRRLVWPTKDVIGRISREESEYFKDQTVLYLRDVYDHIIQSLDMLDISRELSSELMNLYLSSTSNRLNEIMKVLTIISTIFIPLSFIVGIYGMNFVYMPELSLKWGYPVVLIVMGVVVFIMLLFIRRKGWFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F354</accession>
    <name>I2F354_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">Theba_0639</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730434.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0639"/>
    <dbReference type="EnsemblBacteria" id="AFK06357">
        <property type="protein sequence ID" value="AFK06357"/>
        <property type="gene ID" value="Theba_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0639"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_0"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK06357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="215" mass="23824" checksum="E6F3A4F0CCD9F80E" modified="2012-07-11" version="1">MARISPSILAADLTELAREVIRVRDADYLHIDVMDGMFVPNITFGVPIMEALGRLHHPPLDVHLMIEDPSRYVKEYAALGAKNLHVHVEGNYHLHRLLGQIRETGSRAFVVLNPSTPVSLLDEVLSCADGVLVMTVNPGYTGQEFIPEAAKKIDVLDRIRTERDLKFEIAVDGGVSLDNAQDLVNRGADILIMGAAVFRSENPSVVVRKIKELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F366</accession>
    <name>I2F366_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730444.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0652"/>
    <dbReference type="EnsemblBacteria" id="AFK06369">
        <property type="protein sequence ID" value="AFK06369"/>
        <property type="gene ID" value="Theba_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0652"/>
    <dbReference type="eggNOG" id="ENOG502ZC2Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105443_0_0_0"/>
    <dbReference type="OrthoDB" id="1701025at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="212" mass="23549" checksum="FE9B1E1BD0519129" modified="2012-07-11" version="1">MPSKLAVDNVVSKLPGVHSARIVYDESGEMVEIHVLADITKPAKQLVRDIETAIYASTGIKIDRKIVSIAQISLDSNDEDEAVVRPYQKEEVQGYNFQLTSLETRATTRRLDITVVLDYDGKELEGSSIVDVGDDEKYMAIVESTVAAIREVIPSFRIEFIEKLEYGMTEIVMAVGSSLVNGKRKREAGARLCKKDSLNDFALVVLEIINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B3</accession>
    <name>I2F3B3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">Theba_0699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730477.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0699"/>
    <dbReference type="EnsemblBacteria" id="AFK06416">
        <property type="protein sequence ID" value="AFK06416"/>
        <property type="gene ID" value="Theba_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0699"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_0"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="250" mass="26943" checksum="85764D66CF7C540A" modified="2012-07-11" version="1">MVRLKSPEEICKIEIAAKIVAEVLAEMESYAVEGASALDMEKAAEELIHKRGGIPAFKGYSGYPYTLCVSVNEEVIHGFPLKEKIFVDGDIVSVDCGVNKDGFIGDAAKSFVVGSYRSEKDKLLLQRTEEALLKGIEMAVAGNRVGDIGYAVQNCVESAGLSVIRDYVGHGVGLSLHEDPQVPNYGRQGSGMLLRTGMTLAIEPMVASGHYSLEILEDGWTAVTADRSRAAHFEHDIAILEDGPKILSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3B4</accession>
    <name>I2F3B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">Theba_0700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0700"/>
    <dbReference type="EnsemblBacteria" id="AFK06417">
        <property type="protein sequence ID" value="AFK06417"/>
        <property type="gene ID" value="Theba_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0700"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="81" mass="9149" checksum="F2D178C23A07B8E6" modified="2012-07-11" version="1">MSDKSDIIKMDGTVVESMPNATFKVELENNHTVLAHISGKMRKNFIRLIPGDKVVVEVSIYDLTKGRIVYRKRIDKGGETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3H5</accession>
    <name>I2F3H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ORF">Theba_0764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730532.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0764"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="AFK06478">
        <property type="protein sequence ID" value="AFK06478"/>
        <property type="gene ID" value="Theba_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0764"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_0"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="605"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFK06478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="791" mass="89305" checksum="C76E220F50E8FD16" modified="2012-07-11" version="1">MAQKFELLEKAAVGSERKIEIPEKLPVIPTRTNMLVYPSAVMPLYVGREKSLAALEESIGKFNQMVFLVSQRDITKEDPEIEELFEIGTIARIVQLMKMPDGNYKILVEGLTRAKLVSVEEKENSLIVVVEKLKGKGRKSKMLQALVRKVKELALRYVSMSRRFPDEAIMALEDTSDADKFGDFVSSMMPFSLEEKQRLLEEIEAKDRLNTLMELLTREIEILSLEEELDKRVKEKIEQGQKEYYLREKMRAIQEELEGEEDEEIKELKNKAESGELPQEVKEKAEQEISRLEKMSPYSPEATVVRTYLDWLLNLPWQEETDDEIVIRDVRKTLDSNHYGLDDVKERILEFLAARRFSKNLRAPILCLVGPPGVGKTSLGRSVAEAMGRKFGRISLGGMRDEAEIRGHRRTYVGALPGRIMQMIRKLKTRNPVIVLDEVDKMGISFQGDPASALLEVLDPEQNNNFTDHFLEVPFDLSRVLFITTANVLYSIPAALKDRMEIIEIPGYTESEKYHIARDHILPKLLEEYNMDSSKFRITPAAVRDVIRDYTREAGVRELDRNLAKIIRKATLKIAEGSDSISVGVNELGEFLGAPLFKESDFRKHPEVGVVTGLAWTSVGGEIMYIEVLPVAGKGKTIITGQLGDVMKESAQIAASLARKLCDDERFSEVFEKKDFHIHVPEGAVPKDGPSAGITLTTAIVSAVTGRRVRNDIAMTGEITLRGKVLPIGGLKEKLMAAYRARMKKVLIPLANKRDLEKVPDEIKSKLEFVFVEDIGEVLKEALIPGDGKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3J6</accession>
    <name>I2F3J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucan phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730553.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0785"/>
    <dbReference type="EnsemblBacteria" id="AFK06499">
        <property type="protein sequence ID" value="AFK06499"/>
        <property type="gene ID" value="Theba_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0785"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_0_0_0"/>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3417" evidence="5">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="855" mass="98934" checksum="1908013763B45F61" modified="2012-07-11" version="1">MYFLERVMAVPRLPEKLRRLEELSKNLWWSWNYRAQQMFKYMDPEMWYQERRSPIRLLRRISQTRLYELSEDKPFIEMYESVVGEFDEYMGGKDTWMDREHPDRKEQCIAYFCAEYGFHESFPIYSGGLGILAGDHLKTASDMGLNFVAVGLLYRNGYFEQRIDESGWQQNIYHSYEFEDFPVVPAQDDSGDEIFVNIDFPGRKVWAKIWKTAVGRTSLYLLDTDIPQNEPEDRNITATLYGGDRETRIKQEILLGIGGVRALRMLNYSPNVWHMNEGHAAFLSLERIRELVQKNSIDLSTASMIVKSGNVFTTHTPVPAGNDTFSLEIIDKYFRDFWSTIRAERDEFINLGIERLPGGGQQYSMTVLALRLSALANGVSKLHGRVSRNLWNHIYPDLPAVEVPISHVTNGVHIWTWLNPDLVKLLDRYLPVGWHEKVYDPEIWEAVDKIPEEEIWKLHMSLKSRARNFLQGRLKRQRMRLGETIEDLMEVEEALPEDVLTIGFARRFATYKRATLIFKDINRLKSIITNSERPVQFVFAGKAHPADDPGKELIRKLYEISRTPEFKSRIIIVENYDMNIARHLVSGVDVWLNTPRRPHEASGTSGEKAGMNGVLNFSVLDGWWVEGFNGVNGWAIGDNRDYKDHELQDRIDSVSIYSSLEKEIIPLYYSRDEKGVAKEWAKRMKNSIKEIGSKFNTHRMIADYAEDLYFPVADLSKEVEKDDFKLAKSVAIWKDKFSSSWNAIRIKPNMIGETSAKSVKVGQEISVSANIYLGTMDPSEVQVEIFVAKMNDEGEMDGFSLYPMKLVKEDVHGEYVYGGKFTVAEEGQLAYTVRVIPNPERLPHRYFIPVAKWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M1</accession>
    <name>I2F3M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730575.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0810"/>
    <dbReference type="EnsemblBacteria" id="AFK06524">
        <property type="protein sequence ID" value="AFK06524"/>
        <property type="gene ID" value="Theba_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0810"/>
    <dbReference type="eggNOG" id="ENOG503466N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193710_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="232" mass="26131" checksum="A1BF1FAD748097A4" modified="2012-07-11" version="1" precursor="true">MKFAEVAVVILMIFLVLSSILEVTGTNRRASEFFDGMALPLINLRVDIENFFRALFQTRSIDRVIRDLNRYADSFSDKFEFPIPMRVAFFSFERNNTAVMTTNRPALPGTPVASFFSSTIYGVVKSSNERYLLVAPLTSPGTRISAAVHREETVIEGVVYSDAGKLYFSTFDPYYLEAGDPVRIASTVPGYGYYKAMKLDLIGEIAGRHGSDYLVKNPNVFGDYFLFLELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3R8</accession>
    <name>I2F3R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="2" type="ORF">Theba_0861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492572.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0861"/>
    <dbReference type="EnsemblBacteria" id="AFK06571">
        <property type="protein sequence ID" value="AFK06571"/>
        <property type="gene ID" value="Theba_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0861"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_6_5_0"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="123" mass="14161" checksum="6DEE6BD934DA5EE3" modified="2012-07-11" version="1">MASSYRKEMLESEIKKVLTVTLSSYTSYNDSLGMVSIVRVELTKDKRFATVFVSLMGPDESKKKLVKRLNEDKGIFRTAIAKNIRLFKAPEIRFKEDIGIEASLRVAQLLEKIERERTNTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3V6</accession>
    <name>I2F3V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492605.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0899"/>
    <dbReference type="EnsemblBacteria" id="AFK06609">
        <property type="protein sequence ID" value="AFK06609"/>
        <property type="gene ID" value="Theba_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0899"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_0"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="295" mass="32034" checksum="45B657B8BAD6C6A2" modified="2012-07-11" version="1" precursor="true">MSSSVFLQHLVNGISLGFIFGLIAIGYTLVYGVVKLVNFAHGDVFMMATFFVYYGFTLFMMPWWLAVLFGIVVTILLGVGIERVAYRPLRDAPRISSLCAAIGMSFLLQNIATVVFGGRQKSFYVPPSLTRTFVVGGVRIQAITITTIVVSIVVLLLLTFLVKRTKMGLAMRALSVDFDTAKLMGINVNRTIAFTFAIGSALAALSAILWALRYPQIWPFMGVFPGWRAFTAAIIGGIGSIVGALVGGFMLGMVTIMLVAFFPEAAGYRDALIFVLLVVILLVKPTGLFGEKTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F440</accession>
    <name>I2F440_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730708.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0987"/>
    <dbReference type="EnsemblBacteria" id="AFK06693">
        <property type="protein sequence ID" value="AFK06693"/>
        <property type="gene ID" value="Theba_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0987"/>
    <dbReference type="HOGENOM" id="CLU_605220_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="452" mass="51959" checksum="20F10CF21F62CD73" modified="2012-07-11" version="1" precursor="true">MLSRISFTVLIISIILSISGCTGLIRFETEHSHLELIPGENCFELTRGVKISFSNVQKEVSIPYEIERISERTLLVLFREGTASAPGPIFHLSHEALGIEADQVLIVQPILNQTSYVPTEERYEAQFIKDSLSTVVRFTKLPYCLLISRADALYTAQHLPGKFLLEGDLLYHIGPNWIPSHSAVYLGVDYETAMTDEKLGFNNEVTFGESYPFLSHGYNLVEEGVFIFPNDIENHSYVNLFNYDTYESRWLRYWATSFSGARRFPGEISPQDRRKISRFMYETAEKGALWSVGFAWSGFWDLPFTDRDLYSCVGVVEKAYESAGRNIVPFWEDMFYLNSFEQFSRTIPVPEITSMVGDKVEFRINSLLAEWTYVGFDKWSFGDHAWIWKSESNVELLSPQGSLEVKNDHCIFTWTPLETGDYPIIFRFFGEFEGKEVEKYHTLTVHVTGKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A1</accession>
    <name>I2F4A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">Theba_1049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492791.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1049"/>
    <dbReference type="EnsemblBacteria" id="AFK06754">
        <property type="protein sequence ID" value="AFK06754"/>
        <property type="gene ID" value="Theba_1049"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1049"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_0"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="277" mass="31134" checksum="22E81BDEBB9670B8" modified="2012-07-11" version="1">MSKGKLRAIKKRIESTNSTMQITRAMEMVARAKINKIQKGLKFVRLYERAMERALIRAYFGDTSHPKIEGEGEILLVISSDMGLAGAFNAEIMKAAEREITNSDIRHIVTVGIKAESFFKKGDIPISSFSHFYDTPDLDEAAIIVDDALDIMESEHAGGLRMVYSSFKNPLAQIPKAVKLLPLDEFSRPDNDFFDFEPEIDVLFKDVLNSWLVAKVLLGMYETKVGELFSRQNAMKNATENAKNMIQQLTLVRNKLRQSNITQEIIEVVNGAEALNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A3</accession>
    <name>I2F4A3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ORF">Theba_1051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492793.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1051"/>
    <dbReference type="EnsemblBacteria" id="AFK06756">
        <property type="protein sequence ID" value="AFK06756"/>
        <property type="gene ID" value="Theba_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1051"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_4_2_0"/>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="183" mass="20505" checksum="4A0B46D82E8B12CA" modified="2012-07-11" version="1">MKRILSLASKYANALFDSLPSENRETALSQLQQLSQSISNEELSKFLFDPTVQGEKKTGILLSFVQRPLKQIERLAALLVSMKRLELLPDIENAFSARLLVEGRMINVEVDSAVELTSEEEEAILEKVREKTGMQGLLKVTVDPSLIAGYVIRFSDEVIDTSLSGRLKRVSQELRSGPREVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4A5</accession>
    <name>I2F4A5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">Theba_1053</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1053"/>
    <dbReference type="EnsemblBacteria" id="AFK06758">
        <property type="protein sequence ID" value="AFK06758"/>
        <property type="gene ID" value="Theba_1053"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1053"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK06758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="81" mass="8276" checksum="12276BC584FF0C2B" modified="2012-07-11" version="1">MDIGEGLMMMGKFIGAGLAMGIGAIGPGIGEGRVGASAMEAMARQPEMIGTLTTRMILADAIAETTGIYSLVIAFMILLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C1</accession>
    <name>I2F4C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730772.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1069"/>
    <dbReference type="EnsemblBacteria" id="AFK06774">
        <property type="protein sequence ID" value="AFK06774"/>
        <property type="gene ID" value="Theba_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1069"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_2_1_0"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="221" mass="24367" checksum="0627E85727519AA7" modified="2012-07-11" version="1">MILALGVFLPEVKPVMDSMLVLESGEILGRHFCRGVIGNNEVVACGGFVGKVESSMLTQRLIDRFNPRLAVLSSCAAGIDESVQIGDVVVGTEFEEYDTIFPLSEGKMVMKAPDTLLMRFLKIYFKAGKFGKILSGDGVVASASVRDEIHSFHGGIALDMDSAPFAKTAYENKCSYLVIKTILDMADENSKRDFDRHFSELAGRSSELLVEIMKNHYIDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4J6</accession>
    <name>I2F4J6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730840.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1148"/>
    <dbReference type="EnsemblBacteria" id="AFK06849">
        <property type="protein sequence ID" value="AFK06849"/>
        <property type="gene ID" value="Theba_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1148"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_0"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="115" mass="12876" checksum="AB91BCF74E5FE678" modified="2012-07-11" version="1">MNNLPSRGEIWLANLSPVRGREQAGFRPCLVISVDQFNHGPAELVIVVPITSKNKSIPLHVEISGRETGLDLTSYIKSEDVRSISRERLEKRIGRVSDEVMSQVLEVIKILLDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4N8</accession>
    <name>I2F4N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1193"/>
    <dbReference type="EnsemblBacteria" id="AFK06891">
        <property type="protein sequence ID" value="AFK06891"/>
        <property type="gene ID" value="Theba_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1193"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_0_2_0"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="103" mass="11951" checksum="5305C3B7B9B4F8FE" modified="2012-07-11" version="1">MSSWKTRFHPEALKEVERMDGQIKSLAKSKLKQITANPFVGIAVGNKHGIDLTGYYKAYFFKKKFRIVYSIDSDSRTIFVVSINKREDLLAYNNAFKRRQKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4U2</accession>
    <name>I2F4U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730926.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1257"/>
    <dbReference type="EnsemblBacteria" id="AFK06945">
        <property type="protein sequence ID" value="AFK06945"/>
        <property type="gene ID" value="Theba_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1257"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_1_3_0"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="280" mass="31462" checksum="EBBB51AF903A3B65" modified="2012-07-11" version="1">MIRLIVIDLDGTLLNDEKKISQENENAIRCALEMGIAVSISTGRSYVSGHEYVEQLGIDVPVSYQNGALVTFGHGEEIKVISRSVLDPSKARMIYKRATQKSLNTLVFFDFFTLPDISTVGPYDSPYREYYRHNKYRMVFEENPLKRISNDGIPEIAVEGKESLIRDLILESNSHLENVTVVKNDSLEDHAFYEFFGPGVGKEKGLRHILDYLNLDWDSVAHIGDNYNDLEVLKKAALPIVMANGPLGVKKHASFVTDRDNNSGGVAEAIERILRTRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Z5</accession>
    <name>I2F4Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730970.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK06998">
        <property type="protein sequence ID" value="AFK06998"/>
        <property type="gene ID" value="Theba_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1310"/>
    <dbReference type="eggNOG" id="ENOG5032XBP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292714_0_0_0"/>
    <dbReference type="OrthoDB" id="1987712at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="180" mass="21204" checksum="4ECE788E7F4ABC16" modified="2012-07-11" version="1">MFTREYRIVELASHELDLHPAAQLVDLYKLFYQGTFGPSHIMEDQAVALRFLAEEIDCDEFDQVLWQDVSYMENFFRINLVIVKNRQVLIDDLFRALVASSRLGATLSHDEWKEAWYRIESVLRDSIPEEIFTPESSMVVKEAVEGGKLVHHSASYKRSYHPHYRVISREWFERLIGTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F542</accession>
    <name>I2F542_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730991.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1357"/>
    <dbReference type="EnsemblBacteria" id="AFK07045">
        <property type="protein sequence ID" value="AFK07045"/>
        <property type="gene ID" value="Theba_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1357"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540587_0_0_0"/>
    <dbReference type="OrthoDB" id="1715921at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="6">
        <location>
            <begin position="195"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="504" mass="57155" checksum="7F6048AC9D597AAE" modified="2012-07-11" version="1" precursor="true">MRIAISVAELAVTWIIIPFLLFSGAPFSAGLGVTIVASIIIILSLLLAIYSALVVYYWSGRLPTVIYGPEKTVQSGPYRFVRHPFNLGYILFLFGLGLLSGNYWTLLYVAVIGAVIVVYSLLQEKLALKRIEGYEDYKEKIPFMIPNPGRKIPFDKSTSIPWQFIVASFVVKLVILIVLPSKVKNARVLREKRPFVLALAHQTHFDGPLIFYSTSRYLRFVGTAIYVDRLGLLNWLAVIPVRRYAVDTSAIRQMLSTIKQGVPLGIAPEAARSWDGRPLHTKREIWKLFRMLKIPVIPVKFYGVQRLWPRWAKIFALGTSTVEFGDPVEADDPQLEEKVMGFLAKEDPTFKLPYRNYKRIEKLIWRCPSCGAVASIKGFKTGFSCSSCGKSWTKPTVNEVIQIHDRIMPGSMGLSFPIKDEVIFNGERVTANIYEDHAMIGDYKLDYSVINNSSIEKSIEPVFGIANEMVSFVSTTSALMWQELVDFQIKFRLKKENYHTDLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F549</accession>
    <name>I2F549_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1364"/>
    <dbReference type="EnsemblBacteria" id="AFK07052">
        <property type="protein sequence ID" value="AFK07052"/>
        <property type="gene ID" value="Theba_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1364"/>
    <dbReference type="HOGENOM" id="CLU_1480395_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="182" mass="21161" checksum="3D1CA39610B555B4" modified="2012-07-11" version="1" precursor="true">MLLILVLVGSVFASWIPLQDYSTVKYVYNKITYFENGEQKEMLYGVTIDKDEDQYVLNYDTTYFLPLDTELTADMMFGQQFSMMLFTFLNPMLTFIYDAIDLDEQMNTKLYGFGTLKYEGQHSVQGKNGTYTGTKVSLYNEDGELSMYWIIDPNIPFALETFMGEDYAEDSTLIKLWDYALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F550</accession>
    <name>I2F550_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1365"/>
    <dbReference type="EnsemblBacteria" id="AFK07053">
        <property type="protein sequence ID" value="AFK07053"/>
        <property type="gene ID" value="Theba_1365"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1365"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="169"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="353" mass="39896" checksum="7E744509477D2A9F" modified="2012-07-11" version="1">MDLIRVRHSLHEIPEIGFKEFKTQSYIMSLLDRLDVPYEKVSDTGILARWKKSDGPFTLFRADMDALPVFEETGVEFKSKHEGFMHACGHDVHMTILIGLIERVVVANLKRNLLFLFQPAEEGGGGAERCMPALEQYDIKEAWALHVNDEFPEGTVYSRPGVLFASAFEMDCTFTGRSAHVAFYKKGRDAIEGAMDFLQRVYSAERGDSVLRFGLIEGGRVRNVVADSCTLYGTVRTRAYELSEKAICELEELGRDVASSRGLEFKQKIGSKYPQVQVDKDLYEKLCGLVDVNPVEMKYVGEDFGVIALKYPSVLFWLGTGREERHGLHNSKFLPQDSVIEKGIEIFWKVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F558</accession>
    <name>I2F558_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731007.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1373"/>
    <dbReference type="EnsemblBacteria" id="AFK07061">
        <property type="protein sequence ID" value="AFK07061"/>
        <property type="gene ID" value="Theba_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1373"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_0"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="50"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="409" mass="46285" checksum="7565FF4820F567DB" modified="2012-07-11" version="1">MTEKFSKIALRMKSNVIRELLKVTSKPGMISFGGGVPDPDTFPRFEMAEISKEILENEYKLTLQYGSTEGDPILREEYISLLKRESGIEGIDVDNLLVTVGSQSALDLISKILLDEDSIYFVSKPVYLGAASAFSLRSDRHVYMSLREDGADIDEVEQNLQEIENRGELNKVKFIYTISNFHNPAGVTMSLEKRKRLVEIANKYDVLIVEDDPYGDLRYEGKPIDPIFKIGGQERVLLLKTFSKILSPGLRLGIVVGNKTIVKKMVTAKQATDLCTPSLTQRIAARYLQRYDLLSQIEPTIALYREKKDLMLAELERSFGSMEGFHWTKPEGGLFIWFTLPEGFDTAEMLERGKAANILFVPGEAFSLDNTCNNSMRLSFCLPPREDIIEGVRRLKKIVVEYGKEKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F580</accession>
    <name>I2F580_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylulose kinase</fullName>
            <shortName evidence="1">Xylulokinase</shortName>
            <ecNumber evidence="1">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xylB</name>
        <name evidence="4" type="ORF">Theba_1395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731028.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1395"/>
    <dbReference type="EnsemblBacteria" id="AFK07083">
        <property type="protein sequence ID" value="AFK07083"/>
        <property type="gene ID" value="Theba_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1395"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_0"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="250"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="491" mass="53388" checksum="3C36F06EE6B40580" modified="2012-07-11" version="1">MGTFFGIDVGTNSVKGISVDKSGKILTSSSKPIPMETPKPGWAQQHPEIWWDAVCVVLRDLVAKGGRLPSAISVSGQMHSLVAVDAEGKVVYPAILWCDQRTESQCAKVTDLLGGEEKVIGSFGNPVLTGFTLPKILWLAESEPERFKKIKKWMLPKDYVVMKLTGRVVTDFSDASGTSMLDIEGEFDERIPEIIGIDPRSYPELIGSGTIVGTVSSPSLSELEGIPVVNGGADNASSAYGCGVEKTGDAMISIGTSGTVVALTKQGIPDRSGGIHLFRHVTGRDFYHMAVILSATNSLNWFKDRFGNDLSFESLEEMVKQTPSGSNGVVFLPYLNGERTPHRDPSARGTLFGFSSFHSRGDVFRSIYEGVGFALREGAELIESLGSEMNNVRIVGGGSRSETWCQIVADNLGKTIWLPEVDEGAAYGSARLAAEALGIGTSSWIRMKKEFRPNGDFRAVYDNVFSIYKELYPKIRDSYKKISKVQESITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F590</accession>
    <name>I2F590_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731038.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1405"/>
    <dbReference type="EnsemblBacteria" id="AFK07093">
        <property type="protein sequence ID" value="AFK07093"/>
        <property type="gene ID" value="Theba_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1405"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030703_1_0_0"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="273"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="432" mass="47662" checksum="2E4897C21DEA0241" modified="2012-07-11" version="1" precursor="true">MNWNDEYRKKKISIDEGLRNIKSGTKIVTSMAAMEAQGLLKNLHRVEDVENVAVATCLTIGEYPFFVNKEYEGRFLNESWFHSVGARKAVSSGLRTVTYIPNNLHVAGIERIVANKPDIFWGVASPMDRNGYMTVSLSTVYERDMVENAKMVILEVNEKAPKTHGDTHVHISEVDYVIENTFDIPELPDTEPSETEMNIAGHISSLVVDGATLQIGIGGIPNAVARLMEDKHDLGIHTEMFTESMIHLFEKGAITNRKKSLWPGKFIATFALGTKEMYSFIEDNPGVLLLRGSYVNDPYVVSQNENMVSINTAISVDLTGQVCSEAIGTRHYSGTGGQLDTHRGASMAKNGKGIIALRSTAKKGAVSTIVPLLPLGSPVTVPRQDTDYVVTEFGIARLKGLNVFQRVEALLNISHPDFRSELRKQARDIGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5A3</accession>
    <name>I2F5A3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">Theba_1420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1420"/>
    <dbReference type="EnsemblBacteria" id="AFK07106">
        <property type="protein sequence ID" value="AFK07106"/>
        <property type="gene ID" value="Theba_1420"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1420"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_0"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="46124" checksum="892B232787176E9C" modified="2012-07-11" version="1" precursor="true">MIAFASKHNLSGKLSVPGSKSHTIRAVLIAAMAKGVSTIRNPLPSEDCLAATRAARAFGSDVKIEKGVWTIKSSPEGLKIPDDVIDCGNSGTTFYFATAISGTLSDYVVLTGDYQIRRRPVVKLLEAMRKLGAFAVTTRSDSDAAPVIVKGPMRAGTIVFDGKMSQYISGMLLASARLEGKTRIEVQKAIERPYLQMTVDWMSEHGIEVKYDEKNYSFFEVEGPQNYKPVDTAIPSDWESVAFPLVAALVTDSELVIEDLDLSGSQGDAVIVDILKEMGGNVTLNRSSNSLKAVGGTKLRGITIDCSDIPDALPILTVAACYAEGDTVLTGIESIRVKETDRVEVMKRELSKMGASIEDTDHQMIIHGGKKLTGAKVQSHDDHRVAMSLSVAGLFSEGVTEVSNAECVSVSFPGFFELMNSIGAGFQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5J0</accession>
    <name>I2F5J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731115.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1511"/>
    <dbReference type="EnsemblBacteria" id="AFK07193">
        <property type="protein sequence ID" value="AFK07193"/>
        <property type="gene ID" value="Theba_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1511"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_3_0_0"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="210" mass="23618" checksum="C0CC4CEB4348E649" modified="2012-07-11" version="1">MNMVLRWHGHSCFSLECDGKTLLIDPFDEGVGYKLPEVKPDIILESHQHHDHNAHNRFESGYILVNQPVSEKVHGFIIKGHPTFHDDVEGKKRGKNIIFEVTTPDGFRVVHCGDLGHRLGPDLTETLKSPDILLVPVGGVYTIDAGLARELTRDLAPSYVVPMHFKTKDLTFQLAGVEDFLAGEPFEQCEKLELKEKANVGTRVVVLKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5P7</accession>
    <name>I2F5P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487214.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1580"/>
    <dbReference type="EnsemblBacteria" id="AFK07250">
        <property type="protein sequence ID" value="AFK07250"/>
        <property type="gene ID" value="Theba_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1580"/>
    <dbReference type="eggNOG" id="COG3428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101741_0_0_0"/>
    <dbReference type="OrthoDB" id="1870530at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="240" mass="27134" checksum="1B92D086A3E03C9C" modified="2012-07-11" version="1">MDLKPTRRSFMIRYFIYPYYFVLGIVFYLNFDLSGIDGNNWLFLIVSWIALTVIPGILLAFSRKKFGWFFWPAILNASGWLVRYLFPEETYNDLKPLFDNGPVLLFIVAGLLGIVFVEIYRTTFKYNLSDAGVEVTYGMFRANSHMIVARHITNVMLKRNFFELILGVGHVIPVTSSGMGSGDRGVLGGFSADTGTQNVRGGAFIGSVSTEKEFVANPKNCIYGISKPKEIMERLKEMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Q6</accession>
    <name>I2F5Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489376.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1591"/>
    <dbReference type="EnsemblBacteria" id="AFK07259">
        <property type="protein sequence ID" value="AFK07259"/>
        <property type="gene ID" value="Theba_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1591"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="342" mass="38402" checksum="7A2FD59CAE8B983E" modified="2012-07-11" version="1">MAQRVTIKSIAEELGVSVASVSRALNGKGEVGPALEKRILQKADELGYIANYSARSLKHQKTNLIGVLVPDTFNPFFAHFVTKIEELLYDSGYEILLSTTRESLEKEREYLEIMVSKNVTGILAAPVDRTGNISIYKRVKAMDIPIVFFDRNVEGLDLSRVNVDNRSAVYKIVRYLYRKGHRRIAFVESVPNTSMGEERLAGYREAIKDFGLSEEFSLERFGLFIENDVKSQAAEILSHRPTALITGNLVITKAFLQALKTLRIKIPQELSLVSFDDIEWLEVTSPPITAFRQPIESLAMNAVALLKREMKNNESNSQIVVVEGELIIRDSVYDLSSEKQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5S0</accession>
    <name>I2F5S0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR type III-B/RAMP module-associated protein Cmr5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR system Cmr5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1609"/>
    <dbReference type="EnsemblBacteria" id="AFK07273">
        <property type="protein sequence ID" value="AFK07273"/>
        <property type="gene ID" value="Theba_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1609"/>
    <dbReference type="eggNOG" id="COG3337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048623_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023101">
        <property type="entry name" value="AF1862-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010160">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09701">
        <property type="entry name" value="Cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158568">
        <property type="entry name" value="SSF158568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01881">
        <property type="entry name" value="cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="117" mass="13264" checksum="B03A744E66638EED" modified="2012-07-11" version="1">MMPSLNDWAKERVSSILGKCEKVQKSYKSEIKGLGSMLLQNGLYGTIAYYKVRDKDSSKEILADLSSLLSERMEIADVTEMNPINDLDYIKAQTIVLEAVKWLRRYADILIEGEDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T5</accession>
    <name>I2F5T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1624"/>
    <dbReference type="EnsemblBacteria" id="AFK07288">
        <property type="protein sequence ID" value="AFK07288"/>
        <property type="gene ID" value="Theba_1624"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1624"/>
    <dbReference type="HOGENOM" id="CLU_2991477_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="57" mass="6364" checksum="C03FA17AFDED7A30" modified="2012-07-11" version="1">MEDERDFYEDDCLDEDEGFGLEGSACATCWCKGVFCDCCGCTIQEGRNVCENCEDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5V4</accession>
    <name>I2F5V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1644</name>
        <name evidence="3" type="ORF">Theba_1721</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731202.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1644"/>
    <dbReference type="EnsemblBacteria" id="AFK07307">
        <property type="protein sequence ID" value="AFK07307"/>
        <property type="gene ID" value="Theba_1644"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07378">
        <property type="protein sequence ID" value="AFK07378"/>
        <property type="gene ID" value="Theba_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1644"/>
    <dbReference type="KEGG" id="mpg:Theba_1721"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="72"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="558" mass="64501" checksum="74A23EDC79DD32E5" modified="2012-07-11" version="1" precursor="true">MKKRFILLLLAIILVSSLAIGQVYDRKETLYAGGGLWSPPNNWNPFTPWAIMTGTNGLIYEYLFMFDPLSNEMIPWLAVDGGWIDEKTYELKLRDGVYWTDGEEFNAEDVKFTFDIAKKYPGVHYSSMWNWMKEVEIVDRLTVRVHFTEPLYQQWSFQLYQLPMVPEHIWKNKTEAEILTGANEGPIGTGCYTAEGYGQDRMIYLRNENWWAIEQLGIKPTPKRIVYLTVSGNNVALGMIFKGELDISNFFLPGVPAVKSAYGIHTYFDGPPYMLSDNTAVLFLNNSRKPMDDVNFRKAVAWAINADDIVTRVFENQVIKSNPLGFLPIDAWMKYYDEKVVEQYGFKYDPSVSKKVLADAGYKDINGDGFVEAPDGSEIELSIIVPFGWTDWMESIKIIANNLNAVGINAKAEFPDYSRYQDELYGGNFDMAINNFNSNLSNTVWSYYYWLFWDIREQQTQGNYGKYNNPKAFELMEAFDRTPVDDYETGQKIMSELEELFLKEIPYVPLWFNGMWFQASTNVWTNWPSEHGPHYYPCTWNGKWQLGGIFMLTALEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Z5</accession>
    <name>I2F5Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1688</name>
        <name evidence="2" type="ORF">Theba_1755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">MesG1.Ag.4.2</strain>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07348">
        <property type="protein sequence ID" value="AFK07348"/>
        <property type="gene ID" value="Theba_1688"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07411">
        <property type="protein sequence ID" value="AFK07411"/>
        <property type="gene ID" value="Theba_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1688"/>
    <dbReference type="KEGG" id="mpg:Theba_1755"/>
    <dbReference type="HOGENOM" id="CLU_2106050_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="115" mass="13235" checksum="3E0CDE6D6F3AFA8F" modified="2012-07-11" version="1" precursor="true">MSLAVIMVLLLGGCFSFDDMLDGTWSGVLNDYYGNHNVVLIVNSNNTGWISFDNDPYNVDIVSRRANRSFVGEYGWYDSYWIERTIQAEMINYGTLRIKIYDNFGDLISDGFLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F654</accession>
    <name>I2F654_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1684</name>
        <name evidence="5" type="ORF">Theba_1751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">MesG1.Ag.4.2</strain>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731239.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1684"/>
    <dbReference type="EnsemblBacteria" id="AFK07344">
        <property type="protein sequence ID" value="AFK07344"/>
        <property type="gene ID" value="Theba_1684"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07407">
        <property type="protein sequence ID" value="AFK07407"/>
        <property type="gene ID" value="Theba_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1684"/>
    <dbReference type="KEGG" id="mpg:Theba_1751"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_0"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="200"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="418" mass="46711" checksum="E942E0DFA709EE4E" modified="2012-07-11" version="1" precursor="true">MLRFLFREKANRLASVAGIVISLAVVIIAVLLIWSALQEQRSRQYEREISLIGRLVSLGGLSDETFQRLLSESRPEDFEAALNLLKPYGYTEAPPESYGSTYKNFRSRIITIISLSSITLVLLWVSLLSLIAKKQSDFLKETSLRLDALMSGRYDGKSIFDGEGDTAILSAQLNALSRRLEKTMESVDSERDKMRAFISFISHELKTPLASLKTMNELMLDGKNMEREQIEEFLGRSGEDIERMEWLIGDVLNIARIESGAIRFSFRKADLAELARDIMRNYIEIARRKKIEISLNTESSAIVFCDEKWITQAIGNLLKNAIDYSPEGGSVSVSISGSETYAYISVSDEGPGIPQEDSSKIFQSFYRGSSAGRSKKGSGLGLSLAKAIIERHQGDIKLKSSTERGSTFTIELPVRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F681</accession>
    <name>I2F681_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731268.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1783"/>
    <dbReference type="EnsemblBacteria" id="AFK07434">
        <property type="protein sequence ID" value="AFK07434"/>
        <property type="gene ID" value="Theba_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1783"/>
    <dbReference type="eggNOG" id="ENOG502Z95C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051344_0_0_0"/>
    <dbReference type="OrthoDB" id="1001343at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="306" mass="35610" checksum="0FA10A34F2D38C5C" modified="2012-07-11" version="1">MLYLEKEPFRRAQYTILENGRELEKRLFAYYFMDGPANIVVEEIASYQNVDGGFGNAIEPDFRLPASSPMATSVALQHLVHFDDLPLAKGVISKAIAYLDNTYVSERKGWFAVPRTVNDYPHAPWWGCDEEKEICAIDANWGNPTAEIIGYLTRYREFTNLDVDELISQATRYLESMNTFTSFHEILCFVRLYRLLDEKTAASLRPKLYEAVCTLISKDEEEWRTEYVAKPLDFVTSPDEFFCVDRELIEKNIEYYINELHTHGKIKPTWSKSFYDGEMSRAWDEWVAIITLRVLLILKSFGRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6A1</accession>
    <name>I2F6A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731285.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1803"/>
    <dbReference type="EnsemblBacteria" id="AFK07454">
        <property type="protein sequence ID" value="AFK07454"/>
        <property type="gene ID" value="Theba_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1803"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_0"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="116"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="610" mass="67160" checksum="3D31C8E4468E0B2D" modified="2012-07-11" version="1" precursor="true">MNILFLIAASLFAAPLFFLVSKLNKNAAYVAYAAFQIFIFVYVFFWGGSGASYEVVGITGRLNFNFSMPPVNWFFASIVMLIISTTAVFMLPLKKSSVKVFLLSLVTAGAIGAVFSADFLTLMIFWEISTWASLILIIQDKEKSTREAIKYAAIAAVGSYSMLFAIFYMDSRLGTVEFSSVALKIESQPIGVQLTIFIALAVMVLAKMGTFPLHTWLRGSHSSAPDEFSPILSGGLTKLGGFLLFTMTIVFPSFKVFGKLPLFNGIPIVNYGFALLGGISIVVGTVMAIRMEDAKELIAFSTVSNSGYIVLALAIGGTYATAGGMMHILNHAMASAAMFMAIAAVAYRTKTTKMHEMGGLIMKMPVTFAVYLVAIISVAGIPPTSGFVSKWLIYQQLVQDGLPFLAFAAFFGSIGSFMYVFKPLAGIFLGQLKPEHEKVREAPLIMLAPMAFLTFLTVFWGVFPSNAIRSINRITESVGGGTVDVTFSRIVALTGEWDSVLVTTAFAIGFVISLLIFMRAKKARQVDLLDNYTGGDFLYTAELYHFSYRMYRPFDRLFEKWPSMENWLSSTSEKIKELGALFKAVFFNRNPQVYIALTVIVLLGAFWWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6C9</accession>
    <name>I2F6C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate mutase</fullName>
            <ecNumber evidence="1">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="1"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488387.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1831"/>
    <dbReference type="EnsemblBacteria" id="AFK07482">
        <property type="protein sequence ID" value="AFK07482"/>
        <property type="gene ID" value="Theba_1831"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1831"/>
    <dbReference type="eggNOG" id="COG4401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133236_0_0_0"/>
    <dbReference type="OrthoDB" id="1999349at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="119" mass="13397" checksum="F47EF4FD07B1608A" modified="2012-07-11" version="1">MKAIRGATSIEADCPEEIRNSVIELMEEIFSRNKITELHSVIFTVTNDITSYNPATAFRKVFNQSDVALLCLYEASFENSPGGIIRVLLHCESETKNFVYLRRAKNLRPDKVQAGDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6H9</accession>
    <name>I2F6H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731335.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1882"/>
    <dbReference type="EnsemblBacteria" id="AFK07532">
        <property type="protein sequence ID" value="AFK07532"/>
        <property type="gene ID" value="Theba_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1882"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773406_0_0_0"/>
    <dbReference type="OrthoDB" id="1728661at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="136"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="40753" checksum="DF8EEDD9F9742627" modified="2012-07-11" version="1">MDIENDFLFRWYERQLLVEGMTRSFLLRLAEETFGHLWGATEELTAELLIRSGLSGITRDFPRHRILPFYSPLIYRQKETMEFRDGDDFKIEEDCGKRIVSFPHTLSIMFSPLIAGKVFSWLMNGSNEIGPICDLPLDLQKASRKGRVMVVGAGGLGCPLIKILLDNGIDDICIIEPGEIKLNNLHRQILYDYGDVGLSKASVIEKKIAQRYSGVRVKIRKESFDPTLIKTEKPDVVVSCVDNYEARYLINDSCYRNCVPFVDSAVENFGGYAMFRDKRVPCYRCFMGDNRKDTGAQKGILTFVSYFGGMLEAAMVLTFLNTGMCGDDVFWFDLRKGKFESISFERREGCPVCSSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6J1</accession>
    <name>I2F6J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731346.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1896"/>
    <dbReference type="EnsemblBacteria" id="AFK07544">
        <property type="protein sequence ID" value="AFK07544"/>
        <property type="gene ID" value="Theba_1896"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1896"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_0"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
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    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N6_MTASE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="277" mass="31218" checksum="18FD11656D5800ED" modified="2012-07-11" version="1">MNLQELIHISKRKLSEAGIENSRFVMMSLFRGVLSLNEADLILDGEKEIESKLSAKYMKAVERVVEGEPIDYVLGFREFFGIRLEVTRSVLIPRNETEELVEIVIDEEKNSKVFADIGTGSGAIACALARNIPSSLVFATDISRDALMLAEKNARTNGIFNIRFIEGDNISGLNDFLDSVEVIVSNPPYVRTGDLDSLDINVRKYEPMVALDGGKDGLDFYREFLKYLPTGKKVYLEISQYEAEGLRELVSDLNGYSCEFKKDLSGNYRFMILRPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6K8</accession>
    <name>I2F6K8_9BACT</name>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
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                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
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        <property type="gene ID" value="Theba_1914"/>
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    <dbReference type="Proteomes" id="UP000002881">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="153" mass="17720" checksum="CBC25415B2464C03" modified="2012-07-11" version="1">MKNTHRIKVRALIVKDESVLLVRHEHHDRPPFWCFPGGFVESDEDLFSAIKREIREETEVVVSPRSVIALQEFKRESLLEVIFSCDYVSGKLKLGSDPDNPGIPTLVDAKWVRIDELDRFKILPVQLASLFKNSWDNLCSVELFQIETMREVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6L3</accession>
    <name>I2F6L3_9BACT</name>
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        <submittedName>
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        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07566">
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        <property type="gene ID" value="Theba_1919"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502ZVS8">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1684526_0_0_0"/>
    <dbReference type="OrthoDB" id="2046613at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="156" mass="18680" checksum="9A547EF99C0738A6" modified="2012-07-11" version="1">MVKPEKQKGYLVRLKVLKDETDLLRVDIELYKTSTHPVIRDSLFDASIIRASKLVRNSGFTMKTFREYIRQGCPKHFRRELYRIMDDFDREEALLAERIKKLKNRRDRVIVHMDPRFAFHPEREDENRVDLEDIEAICSHLERQVAFFSGKRLDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P4</accession>
    <name>I2F6P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloendopeptidase-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1952</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488158.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1952"/>
    <dbReference type="EnsemblBacteria" id="AFK07597">
        <property type="protein sequence ID" value="AFK07597"/>
        <property type="gene ID" value="Theba_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1952"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_3_0"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="279" mass="31087" checksum="7D67ED2E64B534FD" modified="2012-07-11" version="1" precursor="true">MKAKFALILYVLFIFANACGVGSIRYLVRPGDRLFNIIRDYNLRISTVLDLNCIANPRQLEPGEFINLPTGDGFFYEVQYGDSIDFIAKLFFALAEEIMAANGLKCTSVIYPGQRLFIPLESINVCGSINPGTQFTWPVYGKISSEFGWRKDPFTGVSTFHSGIDIAVQKDAPVFASKDGMVMEAQESGGYGLNIIIQHYDGSKTRYSHLNHISVYVGQRVLRGELIGRVGETGRATGPHLHFEIIDSNDQCRNPRSYLTGINYMYVRREADSLGVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6P6</accession>
    <name>I2F6P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate:ferredoxin (Flavodoxin) oxidoreductase, homodimeric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Theba_1954</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488153.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1954"/>
    <dbReference type="EnsemblBacteria" id="AFK07599">
        <property type="protein sequence ID" value="AFK07599"/>
        <property type="gene ID" value="Theba_1954"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1954"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_0"/>
    <dbReference type="OrthoDB" id="10483at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="738"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="969"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="817"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="842"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1078"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFK07599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1176" mass="129551" checksum="C25BD45AA2C705E7" modified="2012-07-11" version="1">MARVMKTMDGNTAAAHVAYAFTEVAAIYPITPSSSMAELADAWAANGRKNIFGRPVDVIEMQSEGGAAGAVHGSLVAGALTTTFTASQGLLLMIPNMYKIAGELLPGVFHVSARAIAAHALSIFGDHSDVMATRQTGFALLASGSVQEVMDLGSVAHLSAIKSRIPFLHFFDGFRTSSEIQKIEVMDYDDLKELVDYKALKEFRDRALNPEHPKTMGTAQNPDIFFQAKEASNRFYDAVPEIVADYMKEISKITGREYKPFVYYGDPEAEHVIVAMGSVTDTIEETVDYLMKKGEKVGVIKVHLYRPFSAKHFFEVLPNSVKRISTLDRTKEPGSLGEPLYEDVKTLFYGDKNAPEVYGGRYGLGSKDTTPSQIKAVYDNLKLSTPKDHFTIGIVDDVTNTSLEIKEKINTAPEGTIRCKFWGLGSDGTVGANKDAIKIIGDHTDMYAQGYFAYDSKKSGGVTISHLRFGKKPIKSTYLIDEADYVACHKQSYVNQYELLEGLKKGGTFVLNTSWDSEELDRNLPGNMKKYLADNNINFYTIDATKIAMEIGLGTRINTIMQSAFFKLANVIPIEEAIKYLKEAIVKSYGTKGEKVVQMNYKAVDSGIDALKKIDIPESWAKAQDEKKEEDSERPEFVRKVADVMNRQQGDKLPVSAFLGRENGEFPNGTAAFEKRGIAVLIPEWQPDNCIQCNQCSLVCPHAAIRPFLINEEEEKKAPVAFESIKALGGKSFEGLKYRIQVSPLDCTGCGNCADICPAPKNALLMKPLESQVEKEVPNWEFSTTISEKKDVMNVETLKGSQFSKPLLEFSGACAGCGETPYAQLVTQLFGDRMLIANATGCSSIWGASAPSTPYCMNGEGKGPAWANSLFEDNAEYGFGMAMAVNHGRNKLAKIMEELLEQDIPEDMKEPFEAWLKGKDDAKASKAATMGILNAISKGCKNERASTLLKEIEERKDLLIKKSVWIFGGDGWGYDIGYGGLDHVLASGEDVNVLLFDTEVYSNTGGQSSKSTPTGAVAKFAASGKKTKKKDLGRMAMTYGYIYVAQVAMGADKNQVVKAIIEAEKYPGPSLIIAYSPCINHGIKIGMGKTQEQEKRAVASGYWHLYRYNPLLKEQGKNPFILDSKEPKESFIDFLMSEVRYSALKSTFPDIADELFKKAESDAKERYEIYRKLASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Q8</accession>
    <name>I2F6Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488109.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFK07611">
        <property type="protein sequence ID" value="AFK07611"/>
        <property type="gene ID" value="Theba_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1968"/>
    <dbReference type="eggNOG" id="COG4666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645132_0_0_0"/>
    <dbReference type="OrthoDB" id="929438at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="430" mass="46054" checksum="A629A4DEB891CD86" modified="2012-07-11" version="1" precursor="true">MYFHAGLILFVIAVSFGVAKALKLSVELSMLVAALAAAIVHSGGAIPVRHLVEGSFTYLDVCLIFITATFFMNLIKESGGVAFLVRGIVKAFHKSRVLCLFFLTLLLLIPGALTGSGATTVLTVGTLVGTVLTYMGISEKRVAAIIFVCAAMSAAAPPVNLWAMMAAAGSNMPYVGFFIPLLVLSLAGSLFAMFFLGGKGKKVELDEALKELPEPPAKMNWIRVGMPFVVLIFLIMAGRIWPHSIPTLGLPFMFVVASIFAIILSPKKLEILRIASDTINTLIPLVGIMIVVGILIQIMALSGARGLISLAVVTLPMWVLFAALWLILPVSEGLLQYAVAPLLGVPLILLFNMKGMDAIIALSAMAVMWPVGDILPPTAVVGRATVMELKFKGHYYRDFLKTSLIPMGFILLIATLFLIFSNELSFLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R3</accession>
    <name>I2F6R3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6305 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1973"/>
    <dbReference type="EnsemblBacteria" id="AFK07616">
        <property type="protein sequence ID" value="AFK07616"/>
        <property type="gene ID" value="Theba_1973"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1973"/>
    <dbReference type="eggNOG" id="COG4007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1341959_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046272">
        <property type="entry name" value="DUF6305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19823">
        <property type="entry name" value="DUF6305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6305" evidence="1">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="204" mass="22443" checksum="949390E8D56A342A" modified="2012-07-11" version="1" precursor="true">MKIATIFLILIASSVLCSLSIEPLPVIEDPVLFTVWGESIELQNINYFCDSLQVARDYSPGASIEDLCEGAGFRIEEELSGESFHPFYVSGTPYRTLVIIAGSSLPESRADIERIEELASSVKSSNGLVMVIDIDVEGSGDDPLKQEFDQRLVRYLDVLIVAERPVGEYLSFLEGETPIVVELPVVVDLVSIFERDFGGGRCCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T7</accession>
    <name>I2F6T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488057.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1997"/>
    <dbReference type="EnsemblBacteria" id="AFK07640">
        <property type="protein sequence ID" value="AFK07640"/>
        <property type="gene ID" value="Theba_1997"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1997"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="218"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="431" mass="48715" checksum="3045FF34716F8BE3" modified="2012-07-11" version="1" precursor="true">MVKRKSPFKRGMFIFGILLLCFFILIPFYFMIHVSLKADYDPNKLTFSNFTVRNYLEIFGLIQSSETEFFGDEIIRANLEPVLKRIEELEERTASLESYTRYVHEIQLEAKEKELRDIVDLVIDFSGIEVQNREEFIERAITPGTEETEIVEENMKSIFSANDVKKFIDLREEVDSALTEESLLAGLENAKAQLKSYEAQKKKIIEERASEFPFLRYLSNSLVFAGISALISLIVAIFGAYAFSRLRFKGRSSVQRSVLFVYLFGGTVIMVPLYQMAVKLGILATPLGTGIYLIMVYVIQTLPVSLYMLGNYFRTIPFSIEEAAIIDGCSRIQAIFKIVIPLSLPAIVTVYIYAFMIGWNEYLFASAFLGLKSYKDLFTLPIGLNAFSGSAHAVWGRLMAASVVSAVPIIIIFSLMQKYLTSGFTAGGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6V5</accession>
    <name>I2F6V5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731441.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2015"/>
    <dbReference type="EnsemblBacteria" id="AFK07658">
        <property type="protein sequence ID" value="AFK07658"/>
        <property type="gene ID" value="Theba_2015"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2015"/>
    <dbReference type="HOGENOM" id="CLU_1376759_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="72"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="22278" checksum="1D78965E1BFCD359" modified="2012-07-11" version="1" precursor="true">MRVKKQQSFPITRVVLVAFLVISVLLLVILIFHLFRVKSLEGRVANLEKHQAALEMEISAVTGVQRTMSINLYYYNELLDRLMNDEVICDTGAVIPVQRTIPYSQSPINDALRLLLRGELTKAEEDLGFKTEFPGRELQFLGARLENGVLFLKFSDPAGFTSGGSCRVNLLKAQIEKTALQFDSVSSVEFEPIDLFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y1</accession>
    <name>I2F6Y1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731464.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2043"/>
    <dbReference type="EnsemblBacteria" id="AFK07684">
        <property type="protein sequence ID" value="AFK07684"/>
        <property type="gene ID" value="Theba_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2043"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022128_0_0_0"/>
    <dbReference type="OrthoDB" id="650608at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658401" description="POLIIIAc domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="615" mass="69391" checksum="C4D93E614D2AF3EA" modified="2012-07-11" version="1" precursor="true">MKRFVLVALLLLSSVASVGGNLNLYFGNPHSHTSYSDGSGIPEEAYSYAKEVPDLDFLAITDHAYYFAQDLPDGRNKLAATIEAAIEATSEDFLSFVGFEWTATGTGHINVYGTSDWTDRVKSDLWQLYDWIIEHDAVGQFNHPVRDFGDNFKEFQYSPEADLYMNLIEVGNGSWWENDTIVEEMFSAYREALRKGWHLGTTLGQDNHKPNWGGANDSRTAVFATDLSEISILEAFKKRRTYATEDRNIEIHFSTEEAFMGDIVRDADRVELRILIRDTADDPLEIVQIYSNDGVIANFLVDSHEFYIEMTTNIEVGFQYFFVYARGHDGEEAVSSPIWVERSCPIHLYNSAAFPESVKPGERVTLSFQISNLSSEEASSLLQIENLEGIIHEEIVTLEGFESKIVHLERTAEEHDARILFLLDSVPYSSTWLEIRSSASLNVLVDRSHINYASDEREKLKMLLEEMGNRVSTADRIFKVGELDTIDVLLLPLPGVGGSFDRLKILMPQQSNIIKEFVMNGGRLIITGTGDEISNEIISSYNRLLEEMEIYATYEKAITSDAVELDGIVFDGLSVLRGESGRHVYGKGEILLFPGDPFTDNVIENNKELLDQSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z8</accession>
    <name>I2F6Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07701">
        <property type="protein sequence ID" value="AFK07701"/>
        <property type="gene ID" value="Theba_2063"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2063"/>
    <dbReference type="HOGENOM" id="CLU_2633986_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="77" mass="9162" checksum="F30496A3EDC1C0A7" modified="2012-07-11" version="1">MLTGIENLSFNLFGRRFMFALGLRGQAMYSFFETTDNFKTRLSPEISFVNETKMTDRFNFSLFFWPLPVLLGFDMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F702</accession>
    <name>I2F702_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase with chaperone activity, ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_2067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731482.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2067"/>
    <dbReference type="EnsemblBacteria" id="AFK07705">
        <property type="protein sequence ID" value="AFK07705"/>
        <property type="gene ID" value="Theba_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2067"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="794" mass="89058" checksum="14407B4283C4534C" modified="2012-07-11" version="1">MINYEEYTEKAKKILMDVQDILMRYKQNQLASEHILLSMLEDGDNIAIDILNEKRVSIDSLKKDVEEVIGRYGSGGQIGNQIYITPDARHILENARSEARRMHDSKTGTEHILLAMVRETSAVASRLLSKYGVNLDNIYTLILKGRTKGDAEEDENLSSLKKFTIDLTQLAREGKLMPVIGREDEVRRVIQIIGRKTKNNPALVGEPGVGKTAIVEGLAQRIVSGDVPEYLNNKSVLALDMGRLVAGTKFRGEFEERMKGIIDSVRKLSGEVILFIDEIHSVVGAGSAEGSMDAANLLKPALARGELQCIGATTLDEYRKYIEKDRALERRFQPVMVEQPTVEEAYRILEGLKPTYEKHHDIKIEDDALKTAVDLSVKYITDRYLPDKAIDLVDEAASFVRLQTGYMPEKLRSLDRELRELDGEISAHAEKGEYRTAAELKTVAEKKRREFLLEKEKWESEESFGKTVTSAVVASIVEQWTGIPAGKMLQSEREKLRDLESIIHEKFVDQEEAVKIVSQTIRRARAGLNAAHKPWGSFLFMGPTGVGKTELAKRLAFILFGSEEAMVRIDMSEYMEKHTVSRLIGAPPGYVGYEEGGQLTEAVRRRPYSVVLLDEIEKAHREVHSVLLQIMDDGRLTDGKGKTVSFSNTIIIMTSNIASEELASTSELSRAMDLAEESLRKAFRPEFINRLDSIVLFRPLDSEAMEGIVKMRIAEMEKRLSDQRISVEISQKAVEYLAKEGYDREYGARPVRRLIEKLVEGPIADLIIDGALAEGMKVIIDSDASGILVKAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F707</accession>
    <name>I2F707_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731487.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2073"/>
    <dbReference type="EnsemblBacteria" id="AFK07710">
        <property type="protein sequence ID" value="AFK07710"/>
        <property type="gene ID" value="Theba_2073"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2073"/>
    <dbReference type="HOGENOM" id="CLU_2666864_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="75" mass="8419" checksum="36AE87655AB7DE13" modified="2012-07-11" version="1">MEIKGYVEIDGVTYKLISRQKSAHKKLRIRSKGQTGVHLLEEENFLKKNCDYLKSLLNDSEVAIPVGKNGGGQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F713</accession>
    <name>I2F713_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2080"/>
    <dbReference type="EnsemblBacteria" id="AFK07716">
        <property type="protein sequence ID" value="AFK07716"/>
        <property type="gene ID" value="Theba_2080"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2080"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="307" mass="32550" checksum="D822D36B61F6940E" modified="2012-07-11" version="1" precursor="true">MKKTLSLLRRFPIVVGFVGIVLVFSFLSDRFFTVSNFMNVLRQVSINGIIAFGMTFVIISGGIDLSVGSIFAFSAVVGASVIKSTSTFLGILAALGIGALMGAFNGVIIAKMKLQPFIVTLATMAIARSFTQAFTQGRPVTGFPASFREIGRGEIFGIPVPVLIMLGVFVFAWYLLFNTKLGLYTYSIGGNEEATRLSGVKVDRYKIVIYTISGLLAALSALILTARLNSAQPIFGEGYELDAIAAVVLGGTSLSGGKGSIIGTIFGVMVLGIINNGMNLVIISPFYQQAVKGAVILLAVMAERNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F724</accession>
    <name>I2F724_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731504.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2093"/>
    <dbReference type="EnsemblBacteria" id="AFK07727">
        <property type="protein sequence ID" value="AFK07727"/>
        <property type="gene ID" value="Theba_2093"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2093"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068424_0_0_0"/>
    <dbReference type="OrthoDB" id="1590433at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="348" mass="38964" checksum="2CBA4D50AFDD08E7" modified="2012-07-11" version="1" precursor="true">MRLFTNISKEIILGWRSHFFLLTVMLAVAYFLLMTFLIPEDLSTSTQLILLTENEEIARAIEASDRSSESSLSFVNSRDELYESLNRSFNSVGVIMRGDTASPSFELVFQGHEDTKTRELVKLVVAHLLHGSDNQPISSNSVQYLQGKQDDGLDIPFNKSFLPIFLMFEAVMMGMIMVFAMVFSEKSQKTLDAFAVTPGRVWEYLGAKVIFLMILGIVFAIILTALTVGLQAEYLQFVLIVSVGSFLSTSVSLIAASFYENLSQSIAAMLTLTVIFSLPILSYYLEGFSPWYLRILPTFPILFSLQGAVFPHQGSTGMSYLILVAVEAVLAFVIAVNLYKLRIRRVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F729</accession>
    <name>I2F729_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731509.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2098"/>
    <dbReference type="EnsemblBacteria" id="AFK07732">
        <property type="protein sequence ID" value="AFK07732"/>
        <property type="gene ID" value="Theba_2098"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2098"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="255"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="289"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="497" mass="54470" checksum="B7FC87E2B33EB350" modified="2012-07-11" version="1">MPDIALKLEGIYKSFGGIHALKDVSFELSEGEVHALLGENGAGKSTLIKILTGVHKMDSGTIQVQGKTVTIEDPVDARHKGIGAIYQELSLVDSLTVAENIFLGHEPTTSFFGTLRKKELIRRAAEYLSSFGIEIDPSTLVRDLGLGQKRIVEIIKALSINANILLLDEPTTGMSRVEIDTLFEIMDDLKLKKVNMIYISHHLDEVFRVCDRATVLRDGQNAGTFEIDKVDLKTLVKSMLGRTLKEEFPVREGRPSEDTLLEIEEFKTDKMLAPVSFSLKKGEILGITGIIGSGKSELALGLFGADRAIKGKLSIAGKEVRLNSPDDAKRHGISFIPEDRKEQGLFLRLNVEHNICVANIDLAIKNGIISSKKKSEIATDTSEKLKIRPLDIKMAVQNLSGGNQQKVVIGKWLCGEPDILILDEPTRGIDIGAKTEIYSLINYLADRGTGILILSSEFREMSAICDRILVIRKGTIVAELEGKDSSTEQLLTLALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F757</accession>
    <name>I2F757_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731528.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2126"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="EnsemblBacteria" id="AFK07760">
        <property type="protein sequence ID" value="AFK07760"/>
        <property type="gene ID" value="Theba_2126"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2126"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_0"/>
    <dbReference type="OrthoDB" id="595845at2"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657812" description="Glutathione hydrolase proenzyme" evidence="5">
        <location>
            <begin position="20"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="560" mass="60426" checksum="A06736F907EADFA3" modified="2012-07-11" version="1" precursor="true">MKKILFVLTIIVTAGTLMASNPINLYGRDAEGRNGVVAAAKPEASQVGVAILEMGGNAVDAAIATAFALGVLEPNASGIGGGGFMIIRLADMDDAVVIDFRETAPGATSPSFFNLDENNRPINYESTVGGKAIGVPGEVAGLLYALEHYGTLSREQVIKPAIDWAKKGIPVTTNLFSIINDNYEKIMMMENGADIYLKYGGIPYEIGETIVLNDLANTLELIAEKGKDAFYTGEIAEKIVAEVQKRGGVMTLEDLSNYEVKIRKPVCGSYRDYTILSVPPASSGGTHVIELLNIMENFDLESLGDNTAETLHIWSEAMKLVFADRAKYMADTDFAEVPLEGLTSKDYAKLLADKIDMNRPIESVEAGDPWQFESGSTTHLSVMDKEGNMVAITKSINYFFGSGVVVPGTGILLNNHMDDFVKTPGSVNSVEPGKRPLSSMSPTLVLDPEGRPYMTIGAPGATRIITTVAQTISNIIDHGMTVQQAILAPRVFRSQSGPFYIEGRISINAYNKLIQMGHEISIRNDYDPYFGGVHAVLFNRDIGILFGGADPRRDGQAVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F759</accession>
    <name>I2F759_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731530.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07762">
        <property type="protein sequence ID" value="AFK07762"/>
        <property type="gene ID" value="Theba_2128"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2128"/>
    <dbReference type="HOGENOM" id="CLU_773407_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="358" mass="40092" checksum="91F045C87AAA3496" modified="2012-07-11" version="1">MKTMGYSAFLISDAGSVIIEESKHDGITLTFPSDPVFAKYRGRLMAVIEVKMESSKFSLTKSKLDLSGVKLHGVKIVEDKLFEDSVALWAFESRTLGKTLRIVSDGEASKIPAKRDTNFVVPIIVNTIEFSSKEAHTGRLIFPLPDEWFVLSSVYFGQDGAKIRRENAKIDLDSLSTGIVVEELRKHRVFTDNLWDLYQLYKSLESFETKNESLPEPLGEEITVSDLDLEDSIPQAADLYLSKDRKTTDSLHREVVIQSSIEKVGTFSKKKAVVLRIMNNSDLGTIKGIHISFRLIDPMGKELYVAEKELEGLSVGPGEAKKQVFTDFPEFADQQLERVVVNLMSISWSNGLKTLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7G0</accession>
    <name>I2F7G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731622.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2233"/>
    <dbReference type="EnsemblBacteria" id="AFK07863">
        <property type="protein sequence ID" value="AFK07863"/>
        <property type="gene ID" value="Theba_2233"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2233"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579785_0_0_0"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="6">
        <location>
            <begin position="120"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="471" mass="53835" checksum="7F34A1D5DB7A4ABF" modified="2012-07-11" version="1" precursor="true">MSGIKKYFRKTEGESFGTPLKRYFVLILGLLFLSLCFGGSVLPIDIDISAFEERIEANRKVPIKIEIVDENGHPVSDAHVSVRQINHEFFFGNAPEYLIYAYAWTSYNRGRRFGIKPLPEEDLEVYKRLYLDLFNFATLPSFYWKDYEPTQGRIRLDEASKKIAEWLNENGVPVKGHTLVWGNPPSVGVPAWIEVKGKVGQWAEVREALFFRVEREVEEFKDLVQYWDVVNEPIVQSWFDALGPDYIAESFRIVKETDPDAITVLNEYGVLVNERTRKAFISRAQQLIGDGVPIDVIGAEAHIFTAQDLLSQLQSLESIYLAIDELAQLGKPIHISEFQIPLPAVIDAFDVSITEAEEIQAEIAKIFYTVFFSHPAVEVIAYWNFYRAWQSGSGFLRDDLSEKPMFYELMKLIHGDWKTSFEAELDSSGELCFSGFSGEYDITVAFENFSETVSINVKKNENNQFTLVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7H0</accession>
    <name>I2F7H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731632.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2244"/>
    <dbReference type="EnsemblBacteria" id="AFK07873">
        <property type="protein sequence ID" value="AFK07873"/>
        <property type="gene ID" value="Theba_2244"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2244"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_8_1_0"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="268" mass="29942" checksum="7946A983BA57B39D" modified="2012-07-11" version="1">MKVITQDKDFFPSQMEEKLQFIRSLGFDGYEIDGKVLLERFAEVSEAVRSTGFPVTSACGGYRGWIGDFSREKREQATEDIGEILKALSKVGGKGIVVPAAWGMFSKRLPPMVPPRSDSEDTAVLLESLGSLNKIAAETDTFIYLEPLNRYEDHMLNTLQSAAKVIEMGRFSNVRLTADAFHMNIEEADIRQAVIENGRYIGHVHIADSNRYQPGQAHLDFKTLFSALSEIGYSGDIVFECRVIGDDPVKGYGESCAFIRDLLRSIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I1</accession>
    <name>I2F7I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731643.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2255"/>
    <dbReference type="EnsemblBacteria" id="AFK07884">
        <property type="protein sequence ID" value="AFK07884"/>
        <property type="gene ID" value="Theba_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2255"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="316" mass="33174" checksum="48FB132E06B846D2" modified="2012-07-11" version="1" precursor="true">MSGPAVKSKLASFLGKYKIIIAFFVLALVISLMTPNFLSWRNIINIFRQSSIIGIMAIGSTFVIIGGGFDISVGSLLALSAAMAVGLQSSMHWFLAVIVVLLVGAAFGAANGFLSSKIHIPPIIATLGTMTIIRGIVYMYTGGYPLYVDSEGFAFIGNGYIGPIPFPIILLLILVALGQFILVKTKFGRYSCAIGGNKEAARLSGIKVDFYMTLTFVAGGVMAAMSGVVYASRLLSVTPLAGQGYELDAIASAVIGGTSVSGGEGSVVRTLIGALLLTMITNAFNLIGIDLYVQYVFKGLVILAAVGFDSFYKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S8</accession>
    <name>I2F7S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRAP transporter, DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731729.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2358"/>
    <dbReference type="EnsemblBacteria" id="AFK07981">
        <property type="protein sequence ID" value="AFK07981"/>
        <property type="gene ID" value="Theba_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2358"/>
    <dbReference type="eggNOG" id="COG1593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019824_4_1_0"/>
    <dbReference type="OrthoDB" id="903568at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="431" mass="46747" checksum="60B31B70EFCEE12F" modified="2012-07-11" version="1" precursor="true">MGLILFFIIFGATFALGYPIAFGMIMGGFAYFITSGMDLGIFLDIMAIELRAQDVLLAVPMFIFAANVMNDTEITDRLFGFLKQLLGGVRGGLAYANIGASIIFAGMSGSEIADVSGLGTIEIKAMMDDGYDGPFSCAVTCASATISPLIPPSIPMVIYAMLTGTSLGYLFLAGIVPGLFLGFIEAGMALYLSKKRNYPKGQRYPLKVIARSFVRSFPALLAPVILLAGIYGGIFTPTESAAVLAAYSILVSIFIYRTLGLKKLRKIMLKTVYNVGAISFMIAGAFVVKYVLAREEIPLLLTNAFVDMGLLSSAWVLLLSVNVLFFILGMFFDVSVIQLVIIPIVFPLVRAAGIDPVHFGIVTTFNLMLALDTPPYGQTGFITSAISKTPVGKVFKEMLKYWIPIEVMGLVIITYWSDFVLWLPRLLGYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U3</accession>
    <name>I2F7U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731742.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2376"/>
    <dbReference type="EnsemblBacteria" id="AFK07996">
        <property type="protein sequence ID" value="AFK07996"/>
        <property type="gene ID" value="Theba_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2376"/>
    <dbReference type="eggNOG" id="COG4689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042700_0_0_0"/>
    <dbReference type="OrthoDB" id="1270280at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="269" mass="30384" checksum="9B3003899AC60C3B" modified="2012-07-11" version="1">MSGKKGKFVFNADFIYKMPVHFGGAPFYPVRVVYGDNTVISVDYETDENALLSYIPEDFELKEPVVSVQYTNCRDVDWMIGGEYRLIQVTTPVKYVGNSEGLEGVYALVVWENKTCPIIGGREEDGVPKVFADISSERHLENHWFVAASYEQFTFLKIDLQRGDEVSEEDLSELNKDSKINLFGWRYLPNLGKGGATLSHATLYPQEMVLKKMWIGTGSVEWTGLSYEQHPLQTRIIRSLEALPIKRVTSASMAQGIVRLNVGDSRILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U5</accession>
    <name>I2F7U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731744.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2378"/>
    <dbReference type="EnsemblBacteria" id="AFK07998">
        <property type="protein sequence ID" value="AFK07998"/>
        <property type="gene ID" value="Theba_2378"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2378"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_0"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="227" mass="25492" checksum="5FAB7434B55C9D01" modified="2012-07-11" version="1">MTTIYLMRHGQSQANIERIFANGDEGFPLTKEGIRQAEMAARYLRLKNICRIYSSPILRAMETSSIVSSELEIEVKPMDEIREFHVGELEGKLIEGEAAGSFLKLVRDWIGGKEDMRIPEGESHRQVIGRFWKAINTIIDECPEGEVLAVSHGGFLSMTLPFVCSGIDPKSFFSRSGISITNCAITTVKACRCGDSISLELLDWANTSHMELDFEKEPIENIWNSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F820</accession>
    <name>I2F820_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Theba_2462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731805.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2462"/>
    <dbReference type="EnsemblBacteria" id="AFK08073">
        <property type="protein sequence ID" value="AFK08073"/>
        <property type="gene ID" value="Theba_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2462"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_1_0_0"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="205"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK08073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="420" mass="47319" checksum="CEFD3E3C21AE3A59" modified="2012-07-11" version="1" precursor="true">MTSFETVFILVVYGIAFFELFLLSLNFRNAKLSKVSLPDNLRDVFSDDLIEKSVEYSRAKSLFVIVSSVVNLVALSIGIFWGFGVIESLSMKLAEGFALRGLIFFSLIASIYFFISLPFSIYSTFVLENRYGFNRTTPKTFVSDKIKEILLAAGIGLPLVYLALLAIDSFEYWWVYLLIGVVGFEILTQLIFPTVILPLFYKLKPLEDENLAKRIREIADKAGFGVKSILVMDASRKTGHTNAFFTGIGRAKRIVLYDSLLEKHSSEEIEAIFAHEAGHFKRKHILKGMLISNAVAIFAVVLLWMMVESDTVAGIFGVSEKYAILLYAGIFLSSIFTVLDWIDSFISRKWEFEADSYAAMITGDTQPMIRALKNLSVSNLSNLSPHPLYAALYYSHPPSWERIEKLNGIVSNIDERKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F839</accession>
    <name>I2F839_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731824.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2481"/>
    <dbReference type="EnsemblBacteria" id="AFK08092">
        <property type="protein sequence ID" value="AFK08092"/>
        <property type="gene ID" value="Theba_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2481"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309660_0_0_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="916" mass="103790" checksum="150B41DCCF805377" modified="2012-07-11" version="1">MGANLAVPYSTLLPDIEPSYGGGTVWASPPLSENLRRNDGLELKISLSARGHYVIRLGYTVTGSSILPPEVSVEINGAYQFLEAQRVPLVQYWKYETLDFPLNRYGDEVLPSQTMLSTRLDYTLRDSSSLFREPLLFSFEEGENTVKVTLLSGEITLHSLEVLSLEVIPDYTKPDADRPKDDFITIVEAEHPSYKSDTTINSASSRSLDVVPFDTYRSLLNTFGGVSWKNGGQTVFYEFEVPSDGYYSIAFKYIQDSKSKMRVFRRITIDGTVPCKELESYPFDSSTDWKIETLQSGGESLELYLAGGRHTLGIAVDVSVYESVLMTLKTMIAQINDFALQIRYLTGGGEIDRNVEWEIEDYFPGIDETLAAMREALIREYSVASRINGNEHSQELTSFRTAIMFLERLMKDPDDIPKKLDLLVGSVGSIVSELSVALNGFQNMPLTLDRVYIYSGEAAPTFKKASIFASLWEGIKRFVDSFKPVRYKAVGSEGSVVLEVWINRARQYSDIIQQLVDDDFTPRTGIAVDLSIIKDEQKLILANAAGKSPDIALGISNWIPFEMGIRGAALALSDFEDFPLFARNFMPGTFLPFMYEGKVYGLPETQDFYLTFYRKDVLGMLNITVPSTWEEVKLILPELQRNGMNYYIPIGGMASSKAFMTTAPFFFQHQARLYSEDGLSTAIDRKEGLEAIREMTDLFTIYGMPLQVSSFFEHFRKADIPIGVSNLATYVQLMIAAPELKGLWALAPSPGVDQGDVERWQTGSAQAVAIFADTAYPQEAWQFLKWWLSRETQSRFVFQVLSTYGLEYLILPSNRFAFEDVPLPHEDKEAIREQWKWLQEVPRSPATYILEREISNIWNRIVLEGKPIRVAVDEAVQRINREILRKMEEFGYVVDGKKVKEYDIPDLEKILAWWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F851</accession>
    <name>I2F851_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731836.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08104">
        <property type="protein sequence ID" value="AFK08104"/>
        <property type="gene ID" value="Theba_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2496"/>
    <dbReference type="eggNOG" id="ENOG5032Z63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179254_0_0_0"/>
    <dbReference type="OrthoDB" id="2032612at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="102" mass="11954" checksum="C97BD0F9D0232358" modified="2012-07-11" version="1">MANKKREDEWKEVKKKCKVGDETIRMAKELGINPRTMIKNIPNKAEKWKAPVDVWIRDMYDDMKERSAKKAKAKANRLRKESEKLADSSSRLDDSDKSDKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F890</accession>
    <name>I2F890_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytoene dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731868.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2540"/>
    <dbReference type="EnsemblBacteria" id="AFK08143">
        <property type="protein sequence ID" value="AFK08143"/>
        <property type="gene ID" value="Theba_2540"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2540"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682972_0_0_0"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="403" mass="45322" checksum="DA0FC4A68A50D0AE" modified="2012-07-11" version="1">MNGKFFPESKYDVAVIGSGLGSLSAASMLANKGLKVLVAEQHYLPGGCCSIFRRSDFTFDSAVGMVFGFGNRGFNSHRFVFNEIGEDIEMVRHEALYSVTFGEKKIVFWPDLDRFIEELGNNFPGYEEQLRKFYNYLAELYHEVIVADRVIVPPTEMKRSDSLRSLLKHPVRQAKMIRLLFKSTEELMKKFIDPEAKELYQFFDVLTSTYCYTTVKETPGVLAVTMFIDNHEGGGFYPVGSSQMIPSKLEKAIEKNGGYMLYENRVNEILFDDGKASGIKLEDGSEIRSDFVIYGGTVWNLYGGIIPEEHVSQERVEWVESLEPTFPAMVVYAAVDSSAIPAGTNPLEMLVEEFDEIAKSDVTVYIPSIDEPSICPEGTHVMSMIAPSKKKWTPRAASNPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8A3</accession>
    <name>I2F8A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type branched-chain amino acid transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006489485.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2556"/>
    <dbReference type="EnsemblBacteria" id="AFK08156">
        <property type="protein sequence ID" value="AFK08156"/>
        <property type="gene ID" value="Theba_2556"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2556"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="342" mass="37510" checksum="96C3D0E4FCB7B0B8" modified="2012-07-11" version="1" precursor="true">MILTLIALPSIALLLFLSQELLNSYYSRIITLIGIYGIMAVSLTLVNGISGVFSLGHAGFIAVGAYTSALLTLSPEQKEMTFLIEKLVWPLNSIQIPFFWATIIAGLVAAVFAFLIGWPSLRLTGDYFAIATLGFSEIIRIFALNLNSITNGALGLKALPDHTNVWWAWGWLLVTVATVLSLAYSSFGRALRAIREDRVAAQAMGINVFKHQLTAFVLGGFFAGISGSLYGHWLSTIDPRTNTFGILLTFNVLIMIVLGGLGSITGAIIGGALFAFLSEWLRFLEGPMNILGFKIMGISGMRMLVFSGLFVIIMIFWPRGLMGRSEFSWDGLVSVFKRRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8E3</accession>
    <name>I2F8E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2596"/>
    <dbReference type="EnsemblBacteria" id="AFK08196">
        <property type="protein sequence ID" value="AFK08196"/>
        <property type="gene ID" value="Theba_2596"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2596"/>
    <dbReference type="HOGENOM" id="CLU_3137546_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="49" mass="5365" checksum="ABED25BC08F93E66" modified="2012-07-11" version="1">MASRSEVMLPPAGSEARSREEVMPGRTSGEVMLALTCQEAKTKEKERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G5</accession>
    <name>I2F8G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731926.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2618"/>
    <dbReference type="EnsemblBacteria" id="AFK08218">
        <property type="protein sequence ID" value="AFK08218"/>
        <property type="gene ID" value="Theba_2618"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2618"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK08218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="34030" checksum="EA9909D38764ADA2" modified="2012-07-11" version="1" precursor="true">MRTKKVIPYILILPHAVFFGVFFIFPLFKSVYMSLTEWGLFQGMIKYVGLDNYEKIFDFSGYRSEYFWKAIWVTVQFVIYSVPVLVFVATGLALMLNSKKLKAKSLHLTATFVPTALSVTVVAVMWRWILNNHSGLLNYVLSFFGIDKVPWLTDLPWVWFSIVIATVWWTVGWNTVILLGGLKKIPDSLYDSAKVDGANSIQRFFYVTLPGLKQVMMFVVITQVLAGFGLFAQPQLMTGGGPGRETIPIMLHIYGEAFNPSRPRMGYATAMSLITGVIVVSVTFLQYYLFTRSSKEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H3</accession>
    <name>I2F8H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731933.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2626"/>
    <dbReference type="EnsemblBacteria" id="AFK08226">
        <property type="protein sequence ID" value="AFK08226"/>
        <property type="gene ID" value="Theba_2626"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2626"/>
    <dbReference type="eggNOG" id="ENOG5032SRQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818318_0_0_0"/>
    <dbReference type="OrthoDB" id="1387040at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="321" mass="36028" checksum="86F8545989CC9FB1" modified="2012-07-11" version="1" precursor="true">MKFGALFAIFLGMLIILSVTHVIPSFSFAIEIFLAIIFLYQGLKVFKRFKPEHMGSLIFGGILFADLLIGWNVIKGFRGWGFWELVVAMIGSYIVGWGIVTLFKRSFKLGETPNSTRQVLNVSRPKEFEELEIDIDANLTKVLLMDNTSNGFDANVSYDKQSFSGDLKYDMDKGKGSLRARCKARSGVSSVLSKSRMNFELNSEPILRLDATLDGADSVFDFSKLNLDSARIKTSLSRLSIIPSQLRDSIVDIDCEVTSLNIRTPKDVGLSIIHEGELNWSNFNNLMEREKGYVSTNIDRAVTTCQINVKSDMSKISIDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I3</accession>
    <name>I2F8I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted/surface protein with fasciclin-like repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731943.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2636"/>
    <dbReference type="EnsemblBacteria" id="AFK08236">
        <property type="protein sequence ID" value="AFK08236"/>
        <property type="gene ID" value="Theba_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2636"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759801_0_0_0"/>
    <dbReference type="OrthoDB" id="1776069at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="154"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="423" mass="47107" checksum="CF0F2E4D7F9E912F" modified="2012-07-11" version="1" precursor="true">MMRNLIFVILILSSVISLGQEDILKTINETEELSIVASYIQLSGLDQTLSGKGPFTFFAPTDSAFMKLPELTRADLINDVVRLQRVLKYHIIQGKFSSSIIVQRPNFVTLLGQPLSVDTKGGIKVDGSSILVRDIEATNGVIHIIDTVIFPHEEPDIVQVMRNTGILDTAVFSLEETGVIDILKGEGLYTVFMPSDVAFARLPPETMENLFRDPARLSDILLFHIVEGSFSVEELFERGSIRSLLGETIVLGTTPPRIGPQKTVVILSDIEASNGMINIVDHVMFHEDSRTKLSTIEETLKANEIDIMAELLKKTGICSELSENKRLTVFAPTNEAFLELKESDKAFLYSANELRKVLEYHTLPNEYLLSELKISNMLLSLIGKPLYFEMKEDLLVNSIPIVESDILCSNGVIHIIESLLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8I8</accession>
    <name>I2F8I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731947.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2641"/>
    <dbReference type="EnsemblBacteria" id="AFK08241">
        <property type="protein sequence ID" value="AFK08241"/>
        <property type="gene ID" value="Theba_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2641"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_1_0_0"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="253"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="397" mass="44843" checksum="0809D6D5224F8814" modified="2012-07-11" version="1">MSDTVRIAEGIYWIGVNDFETNLFEALWPLPRGVSYNSYILIDDKVVLIDTVKGPFFSDFLDKIRSLLPEGRKVDYLVVNHMEPDHSGSIKVLREAFPEIKIIGNEKTKGMLDAFYGVTDNVVTVKDSDELEIGSKTLQFHMTPMVHWPETMMTFEKTTGLLFSGDAFGGFGALNGGIFDDEVDVDYFEDEVLRYFSNIVGRYSSMVQKAFEKLKNVDIKVVCATHGPVWRKNPSRIIELYDRWSKEETEEGVVLVYGSMYGNTQKMMEAVASGLVKGGVDKIRVHNISTTHISFIIRDIWRFRGLVLGSCTYNMELFPPMKQLVSAIENRMMKNRKIGVFGSYTWSGGALKELQEFASKSKCDQVCPVIEAKSCPTQEDLEKCVELGLNMASAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8L1</accession>
    <name>I2F8L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487277.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2665"/>
    <dbReference type="EnsemblBacteria" id="AFK08264">
        <property type="protein sequence ID" value="AFK08264"/>
        <property type="gene ID" value="Theba_2665"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2665"/>
    <dbReference type="HOGENOM" id="CLU_2001181_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="124" mass="14110" checksum="36EA32B389AD4B99" modified="2012-07-11" version="1">MSIGEASLDSRSFKFSNEGSVDVTSFAKQVGIKLPVVISKNVWNEMVKTDENARMYGQNEEKRLESLLSTLRMELLKGKAKDLSFTFFICKDPKTTSCRLLKACYKDKDNGERYLKICTYDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N4</accession>
    <name>I2F8N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731982.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2688"/>
    <dbReference type="EnsemblBacteria" id="AFK08287">
        <property type="protein sequence ID" value="AFK08287"/>
        <property type="gene ID" value="Theba_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2688"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="252" mass="28103" checksum="9BF4EFF26DE70E6B" modified="2012-07-11" version="1">MDILRTENMTKRFGGVVANNDLSIGIPEGEITALIGPNGSGKTTFINVVTGVHPITSGKVYFKDQDITGMEINRISRLGIARTFQKIRLFENLSVIENVLVARKSFYKSGPLSVVLGTPSFRKEEKENREKAMELLELVGLEDNAYDSPKGMAYGLRRCLEIARALALEPQLIFLDEPAAGMTRDEFKVIMNLMMILKEKGITILLVEHTMDFIKAVADWVYVLNFGQIIAKGTFDVIEKDPLVLKAYLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8N6</accession>
    <name>I2F8N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731984.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2690"/>
    <dbReference type="EnsemblBacteria" id="AFK08289">
        <property type="protein sequence ID" value="AFK08289"/>
        <property type="gene ID" value="Theba_2690"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2690"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_0"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="296" mass="31981" checksum="FEE01D4B182F59F8" modified="2012-07-11" version="1">MLQDILQNIVSGASIGATYGLVGLGVVFLWLTISRINFANISSAMLGAYLFYSFYTQLNLGFFISFVLSIAIIGLYGLGLRIFIYEPIRKRGGGRLEFVVATLMLCTFWLNFIIVTYGALPKPFPPVFGGSNDFISLGGIRIPSLYLNIYLVIAILMVFIYFILNKTLIGKSFRAAAQNREAAALMGIDVKVTTSLSFILATVVVGIAGILLAPIYFVSLELGGGSIGVKGFASAVLGGLTNPYGTILGGISLGLLENFSTLYISSTYRDVISFSVLVAVLILKPSGIFNWKRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8R1</accession>
    <name>I2F8R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014732007.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2716"/>
    <dbReference type="EnsemblBacteria" id="AFK08314">
        <property type="protein sequence ID" value="AFK08314"/>
        <property type="gene ID" value="Theba_2716"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2716"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033989_0_0_0"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="1">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="409" mass="47108" checksum="9871D5D39630EA81" modified="2012-07-11" version="1" precursor="true">MKRIQFIGIILIMWTATFSVQNLADLSSEDWIEDIEYLEERLISIHPNPFFRIDRGVFQTSIEALEQSLEELSWYEIYTRLTEIVASIGDGHTVVYPQGSSTLYPIYTYWFSDGLYIIATSESEQRLLNSKVLEISGMKVDDALKALRRVVSHDNEWGFMNSHSDYLNKPEIMMGLGLADKDGNLVLKVENNGVVNEVLVEPQNTGFQWVQKRIEEIDRTYIGRKYWYQYYPDSKILHFHYASCGSEKGNPFIFFNFEMFLFTWTNAVDKLVIDLRGNGGGSSAILEPFILRMMIDWRLNRTGKLFVLIDRGTFSSAVLNAISLKKRTNAIFVGEPTGGSPRHYGEVKRFVLPNSGISVSCSSTYWRTTSDTSPAFMPDIIAIRSFEDYYYMRDLAMEAVESYRTEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8S6</accession>
    <name>I2F8S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487411.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2735"/>
    <dbReference type="EnsemblBacteria" id="AFK08329">
        <property type="protein sequence ID" value="AFK08329"/>
        <property type="gene ID" value="Theba_2735"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2735"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_0"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="59" mass="6238" checksum="B3D56341913859A4" modified="2012-07-11" version="1">MKVYVDKDTCIGCGVCEGICPEVFKMNDDGKAEVIVPETEAACAQDAADSCPVQAIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1H1</accession>
    <name>I2F1H1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="7" type="ORF">Theba_0019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487455.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0019"/>
    <dbReference type="EnsemblBacteria" id="AFK05774">
        <property type="protein sequence ID" value="AFK05774"/>
        <property type="gene ID" value="Theba_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0019"/>
    <dbReference type="eggNOG" id="COG1481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053282_0_1_0"/>
    <dbReference type="OrthoDB" id="1634356at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="6">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="308" mass="34933" checksum="D19D9B482931C882" modified="2012-07-11" version="1">MSYADKLKEELCHLPLDDQAECRAEYLGFVKSRGTLRLRGNTSFLVIPLTSITSLKRLFQVSKRLSIPIFETQVIEEVRLDRKRGGELSYLYGEVEEFLRRNGISVRDDSIPRPVREDPVYFGAFLRGLYLAGGSVVDPSKEYHLEITLDTTEAFVNSVKQYVSENFNIKVGVVKVRDKFKAYVKSSMDIIELLSLMGGKKTVTRLSSAIEVRKIRSDVSRTLNFLTANANKSGQAMAKHVKAIRIVDRKLGIENLEEDLQQVAILRLENEDLNLRELGEIMNPPMSKSAVYNRLKKLMALAEELGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1K1</accession>
    <name>I2F1K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein of DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490088.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0053"/>
    <dbReference type="EnsemblBacteria" id="AFK05804">
        <property type="protein sequence ID" value="AFK05804"/>
        <property type="gene ID" value="Theba_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0053"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102849_0_0_0"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="167" mass="18690" checksum="4BBFBD4476A9353B" modified="2012-07-11" version="1">MTEFSFPEHSTELLETLRDGRVLIGVTDGVETNLITVGWGFLGYTWNRPVFIAMIRPSRFTHDFFRSSDGFSVNFMSAKWQEALDFCGTRSGKYFDKFKETGLTAREGLSPSIVVVDEADKVLECRVVSKEALTPLALNGSIASTFYGDNSYHSLIFGEITDSYTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1L0</accession>
    <name>I2F1L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014729987.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0062"/>
    <dbReference type="EnsemblBacteria" id="AFK05813">
        <property type="protein sequence ID" value="AFK05813"/>
        <property type="gene ID" value="Theba_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0062"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451148_0_0_0"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin" evidence="1">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="1">
        <location>
            <begin position="142"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="318"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="605" mass="65016" checksum="CC5C8C94BE3D3D7F" modified="2012-07-11" version="1" precursor="true">MVVKRNRLVLLLSILIILLLTACPRNPENNDPVWNLPVGDRSVEETETLEITLSDHVSDPDGNSLSFSLSGKGSISAGGVYSYSPGIGEASTDFEESAVYAVTITANDGKGGAASENFNVTVTPENDPPVWLTVPDKTVQEGSTLTILLTTYASDPDGDALAFDIPEGPGEIDGNNYEYTPSYEEAAMNFEEAAVYNVELRAIDSKGATATTSFQVTVTNKNRVPELSIPSPQYVTAGKTLTLDVALFAYDPDGDAISFSKVAGVGSVTGSTFTYSPALSDSGTRNATIRANDGNGGVTDQTVEININASHINNPPNVPGKPLPANNAMTQPAALTLTWFGGDPDGDPVTYDVYFGLSPAALSFKTNTSTRTYSTGSLNSSTYYYWQIVAKDNKGASTTGPVWRFRTAPTQAFVENFESYSAGSIVSSFGPWYYQEYGSVTNPIITEIAGHGKVIAFYGGNGYSVVYTPKVDPFKLGYLEYDVRLASTSIPRWGWIGPNNSLAYTGIGYLDGKRAIVCWTQEGGSYHSERVMDIGPGIWYRVKVVFNMSTGGAAVYVDGTFKRSFSFTPVPSGTNGVRMSTSNYNYSYVMFDNISLWVTDTGYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Q9</accession>
    <name>I2F1Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylhydroperoxidase AhpD family core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730028.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0113"/>
    <dbReference type="EnsemblBacteria" id="AFK05862">
        <property type="protein sequence ID" value="AFK05862"/>
        <property type="gene ID" value="Theba_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0113"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115251_0_0_0"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="204" mass="23022" checksum="06D420B6E08568F1" modified="2012-07-11" version="1">MNQKFYKRFFTFKECYQILFDAMRTMKYMSRAKRKEELSTELIEKVMLTVTEINGCEVCTVFHNKVAEKEGIKEEEIQMLFVADVEEIPQEDAPAILFSREYANSSGNPSEDSWNSLKALYGESKAKGILGAVRTIMMGNALGIVWGALVNRIKGKPVEGSSLWYEISMLVSFIFLIPVALVHALLASLFKKPIIAFQTQEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1T2</accession>
    <name>I2F1T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730050.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0139"/>
    <dbReference type="EnsemblBacteria" id="AFK05885">
        <property type="protein sequence ID" value="AFK05885"/>
        <property type="gene ID" value="Theba_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0139"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057454_0_1_0"/>
    <dbReference type="OrthoDB" id="1840229at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK05885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="373" mass="42660" checksum="C0C9333AB44C7DC4" modified="2012-07-11" version="1">MNSTRMSINHKTLAETRVNLGFSLDAAAKKIGVKSLVLASWESGEKKPTYIQLMKASRTYGLPSAYFFGDNVYAEEQPPDFRSFPDILQRQIPEIRLEIRYARERRETAIELLSELDEDIPYLEIPALKNSESLTKVIRDVLGIQVDTQMKWSNPYEALNKWCLSFEKAGIIVFQFSGIDVDTMRGFCLNERPLPVIGLNIKDSPHARIFTLFHELRHLVFREGGICDLHDSGHEKLCNEFAGEFLVPDQDLLRIRAVRTHTGVTWETSELNELSRIFSVSQEVILRRLLSLGLTTKSFYQQFRVASVEKSRRPSSRGYMSYTVRLLKENGAFFTNLLVSSYDAGVISSVDVSSSIRGAKVEYLEKLRKMIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1X4</accession>
    <name>I2F1X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730091.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05927">
        <property type="protein sequence ID" value="AFK05927"/>
        <property type="gene ID" value="Theba_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0187"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097947_0_0_0"/>
    <dbReference type="OrthoDB" id="1493141at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="256" mass="28889" checksum="FDD2A1CC80463D36" modified="2012-07-11" version="1" precursor="true">MFYKEIHEMKLRVIIMFIVLLVSLVITVALRPYAAQMMEEMTAQLEEMPDFLKSLMGDVSGLTRLNDDNYYLLSQWHGKNYGQFLPFVVLLIAFPIFAKEFDKKTIYFLLSRKNRNEVFRTKYLAGLGALLIITTVLSLLGPIAMNLAGYSTAFGDTLKVLLQQLVGASFFYSLFTMISIMSRDQVKPVVAGILIVLGLPILGMIDALSWLNPYPFILGSSVAQKGTIDWIYLVSLLAATVLLTVIDYKVFEKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Y1</accession>
    <name>I2F1Y1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pnp</name>
        <name evidence="9" type="ORF">Theba_0199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730098.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0199"/>
    <dbReference type="EnsemblBacteria" id="AFK05934">
        <property type="protein sequence ID" value="AFK05934"/>
        <property type="gene ID" value="Theba_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0199"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_0"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="631"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK05934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="730" mass="81245" checksum="3F19853C70D65223" modified="2012-07-11" version="1">MSYRRWEREFFGQKLVIENGKMAKQADGAVVLRYADSVLLTTVNGNEQAVPGTDFLPLTVEYQEKFYAAGKIPGGFLKRESRPSDNAVLSARIIDRPIRPLFPDGMRNEIQVIVTVLSADPDNPPDIWGIMASSLVLNISPIPFEGIVAGVQVGYVDGKYVVFPSADELERSELDIVVAGTEDAVAMVEGEAKEVSEEVMVGALEAAHEAIKSLVAFQKEIISEFQTEKWELEIPAAPEGFLESFDTLVDRNKLAEIMLTPGKKNKDKALKTYRDELIEQFIGKAKETWSEEEIEDNIGFVKDFYHDIEKKVMRRRVIEEDVRMDGRKHNEIRPINIELDLLPRAHGSALFTRGETQSLGIVTLGATMDEQIVDTMFEEGSKSFMLHYNFPPFSTGEVKRLRGPGRREIGHGHLAERSLKNIVPNGESFPYTIRVVSEVLESNGSSSMATVCSGSLSLMAAGVPMEKHVAGVAMGMIQEPEKTVVLTDILGNEDHMGDMDFKVTGTRDGITAFQMDVKVSGVSSEIMTKALEQARLARLKILDLMYEAIPEPRKFVSDYAPIIRTINLPYEKIGEIIGPGGKVIKKLSSEYDSTIFIDDERSQAKIVGSNREKLDQLEKVIDAIISEVKPGQLFEGKISRAEAYGFFVEIAPGKTGLLHISKMGASGKDFLREHKVGDTIAVEVAGTDQMGKISLKLEGVEVKEDSKRDNKRPYHRNDRNDRNRGDRNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I2F1Z6</accession>
    <name>I2F1Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730111.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0215"/>
    <dbReference type="EnsemblBacteria" id="AFK05949">
        <property type="protein sequence ID" value="AFK05949"/>
        <property type="gene ID" value="Theba_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0215"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK05949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="338" mass="37764" checksum="96CB4286207AFA48" modified="2012-07-11" version="1" precursor="true">MNERKALLQVEDLRTYFHTEDGIVKAVDGVTFDVFPGETLGIVGESGCGKSVTSLSIMRLLDEKGEIAGGKIIFDGEDVMAIPESKMMKIRGNEMAMIFQEPMTALNPVFTIGFQIMEAILLHQDVDEKKARQMAIDMLKKVGIPEPEKRIDEYPHELSGGMRQRAMIAMALSCNPKLLFADEPTTALDVTIQAQILELMKSLQDQYGMALVMITHDLGVIAEMAQRVVVMYAGKVVEYADVHTLFKNPRHPYTWGLMNAIPRLDEDKEVLYNIPGVVPDPLDFPDGCRFNTRCPLATEKCRKEEPPLVEIENDHTAACWHIDKLIETIKVARAGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F207</accession>
    <name>I2F207_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730122.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0226"/>
    <dbReference type="EnsemblBacteria" id="AFK05960">
        <property type="protein sequence ID" value="AFK05960"/>
        <property type="gene ID" value="Theba_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0226"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251777_0_0_0"/>
    <dbReference type="OrthoDB" id="541762at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="931"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK05960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1442" mass="157629" checksum="824D5D8FA827C491" modified="2012-07-11" version="1" precursor="true">MRRYRNTILISVLLFIALIFSSCVPRVNLFTVEVVSEPDAISVALLKDIEQANYEASDVQKTPLVLNLKPQETVVVKVIEEEPLEETEVIHVFDGWADGSKANPRAITADSNKKVEIKTVKNVRVSISTSPRNLVEVVGSGFYPVDTELDLSAPAEVGDYHFAYWNIDGSREYSQELSLKLDGPTKIEAVYENRPLRTLEIDSQPTGLNMSVDGQEILTPYSIKSEEGESHTVAFLPQERDLSNLVNGTDTRYSFKSWSDGGTSNPRTVLLNSDLSLNAITGIEYLTVTSTVPEGISEFSSAAWKTAGSSVSYVAPEVPGYIFSHWEVDGEDVLTKELSLIVDSPKSIVANYSLVGHVLSLDTDPSGLEILINDKTFTAPASLSGSYGDLFTVEIPEPQTRDESEFVTGIDARYTFGRWNDSIETNKRTIKLDSDKSYTATMEIEYLVETGTMPEGLSEIPGAGWKAKGSFISYESNDLIGYTFSHWEVNGERVDGEILDLVVERPTKILAVYRNKEESTLEITSNPEGLVFSLNNEVYSAPKSFVFESGTSIEVSFPASQEKDNSEQVLGNDTRFLFSKWADGLAENTRTVELTEDIRLEAIANTEYLVEVSSETAQIGGTGWYRKGYSLNINAPEVSGYKFVSWSVDGAKAVRNPLSVTVDSPKKIVAVYEEAVVSNKTLTVSTTPEGLLVKIDGNQMVSPCQITAAEESSHSISTITPQEKDISTQIAGNDVRYVFSAWNDGSTLNTRTIELNSNLSFVAAFGEEFKLETATQPSGIVQIGGTGWYHDGEKVVLNAAAVEGYNFLHWSVNGVKAGESSTLEFIIDEPTAAKAVYNSLPTISLEDREVSEGEVLELLLSEHSADVDGDTLSYSLLSGPGSISGGIYSVDTSELNAGLHEITIEVYDGRGGYAADGFTITVTEQNNPPAVPGSPSPASGSVDQELSIELSWTCSDSDGDALVFDIYFGSSSSPEKVASDILANNWQSTNLSEGVTYYWKIVAKDSNGATSESSVWSFSTKNSLPADGVDKVGPVYMGDLLLISNENPDCYSYENTGSLSEDFVQTASLPDDLPLEAYAMNPILPEPEGLTLDKLVKLGDNFEVAAVGSTSEFWVYNFKTNTTEKLTATLQYSGSKSEIWVENTEEIGQQQAQQLGSEFDDSIYPLIANYFYTPSDLDVNGKVKILCFDIQDSFETTGSYYAGYFSSGDLFNHSTSNMGELFYIDTYPSMHYPKTNPIDVSRAFSTIAHEFQHMVNYNRNVLVEKGSTMPTWLNEGLSLAAEHLYSGVLSRRISYFNSSPRIRDGHSVLYWGDNGDTLSSYALSYIFLQYIRAQAGNDAIFRDILLSNDNSSNVIVSALTKYGVTKSLGEILTDFRIALVLKNGSGPYGFRGDGDFNSIAVQFYSGGSKELRGGSAVYKSINPSFTDPENSGDSIAYVGITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F217</accession>
    <name>I2F217_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">Theba_0236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730132.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0236"/>
    <dbReference type="EnsemblBacteria" id="AFK05970">
        <property type="protein sequence ID" value="AFK05970"/>
        <property type="gene ID" value="Theba_0236"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0236"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_0"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="457"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFK05970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="608" mass="66795" checksum="8CF8D0161DF8B8D5" modified="2012-07-11" version="1">MCGIVGMVGKDLTIRKLVDALKKLEYRGYDSAGVAVNSRDGLRVMKAVGMISSLEKLLGDDLDSNVIQGIAHTRWATHGGPSDFNAHPHTDCTGKIAVVHNGIIENYDVLRLDLEKKGHIFKSVTDTETIAHLIEEHYSGDIISAVRHALLDLEGAYAIGVVHQDHPDVIVAARKGSPLVVGSTGESGFLASDVTPLLKYIRDVYFVDDGEFVVIRPEGISISRMDGTSVRKPSTKITWSEDSAEKSGYEHFMLKEIFEEPQTLRNALMGRIRGGVPNFNEIEHLREEIEKARSLTILACGTSFHAGLVFQRFLQDYTEIRAEVEVASEFRYRRLQEGFSDLVVAISQSGETADTLEGIRKAKKLGTKIISLTNVVGSTISRESDAVIYINAGPEIGVAATKTYVAQLAVLLLLGAAIADIAGRSGFDIPKIVNELEGMPTVFENTLPTADEQCKRLAAEHSDYKHFMYIGRGYSYASALEGALKLKEISYIHASGYQAGELKHGPIALLDKDFPVFAIVPEDELKSKMISNIMETRARDAKVLALCSENDKEVAKSVNSRIEVPRVLDPIYPLVMSPYLQLFAYYIAVKKGLDPDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F220</accession>
    <name>I2F220_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-binding protein, possibly nucleic-acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730135.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0239"/>
    <dbReference type="EnsemblBacteria" id="AFK05973">
        <property type="protein sequence ID" value="AFK05973"/>
        <property type="gene ID" value="Theba_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0239"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_1_1_0"/>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK05973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="178" mass="19728" checksum="C44AD51D4B606238" modified="2012-07-11" version="1">MAKIHELIVDLNSFEFKKTIDLVLDPGFTDEIKLLSNVDVHIELYKDKDSIIVTGSVKTVVEDRCARCLKVVSIPVEGTVEATYVQRDSLPLVREGAGDDLENLLPLEGDLLDLSDRVIEAIIVEVPQKVLCKKDCAGLCPFCGADLNEEPNHSCQKKEEMPDGWHKAIAELKGKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F233</accession>
    <name>I2F233_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_0252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK05986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730146.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK05986">
        <property type="protein sequence ID" value="AFK05986"/>
        <property type="gene ID" value="Theba_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0252"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_3_0"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK05986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="363" mass="40011" checksum="09FAA4F9B49AAE02" modified="2012-07-11" version="1" precursor="true">MKKTKFWVLGYFIAVFMTLFLFPTTSRVLGLAFIFSLIINTPAQFVSRKIPRGALSIVTGIALLSFMFFLIYRVVPITISGVKGLSLELDSLFNGGTFDKWLEKLPPFISEAIVDIVESASQWLSDAAIMIGQYVASNITSWITGVVLLIIAGFVVARKTNMIQKSVPVLFPGCDQDKVSSFFHSLYKDFQTYIGGQLIIALVVGTIIAIGSAILGIPNAIFLGLLAGITNFVPYLGVVVTSIPMIVLSFVSKGLWGVVGAIVLLVIANQMEIWFLSPKILSNRVKINWFIVLVSIIGFGELLGVFGVVFAVPILIFIKRYWMDFILSERSGSNWESTIETGIKKAKIRKEHHPEEPTGSQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F251</accession>
    <name>I2F251_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0271"/>
    <dbReference type="EnsemblBacteria" id="AFK06004">
        <property type="protein sequence ID" value="AFK06004"/>
        <property type="gene ID" value="Theba_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0271"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="267" mass="29638" checksum="12468AF79D70058E" modified="2012-07-11" version="1">MGNTGKIKIGIVQFRADNDAPGENLEKITSYIESLVEENVDLVLLPEMFNSGYGTDEATISNASEMQEETVEVLSALADYNDIAVVGGIVNKTNGGFFNSTVIMLPYLEPIYYNKTHLFRDEKKVFTPGSEFKTFEFSGIQFGVLMCYEIGFPEISRKLCKQGAEVLLVPFAFGRERKLIFETATRARSIENGCFLVASSQCGTNKTMNFVGGSRIISPSGEIIVDCGGAEGFASAEIDIRLVKKYRFGESRDSHGYFSNFRDDLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I2F268</accession>
    <name>I2F268_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplS</name>
        <name evidence="7" type="ORF">Theba_0289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006491761.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0289"/>
    <dbReference type="EnsemblBacteria" id="AFK06021">
        <property type="protein sequence ID" value="AFK06021"/>
        <property type="gene ID" value="Theba_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0289"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_0"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="115" mass="13073" checksum="4FEE359990B977D1" modified="2012-07-11" version="1">MDQYIRSLENEHLRDDLPKMGPGDTVRVSVRIKEGNKERIQAFEGIVMGIRGSGTGKSFTVRRVGAAGVGVERIFPFTSPSLEKIEVLRRGKVRRAKIYYIRDVKGKVKIKEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F281</accession>
    <name>I2F281_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_0303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730177.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0303"/>
    <dbReference type="EnsemblBacteria" id="AFK06034">
        <property type="protein sequence ID" value="AFK06034"/>
        <property type="gene ID" value="Theba_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0303"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_0"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="231" mass="26255" checksum="3CD7A86D19A120CF" modified="2012-07-11" version="1">MRLDAFVSRFGRFSRSESRRIIRSNGVSLNGVLTNNPSEVVDETDTVIVDGRPLEAFWNVYIALNKPEGYVCSRERSEGRSVFELIDANFSADLSTGGRLDKDATGLLILSNDGKFIHEVISPRKLVEKEYLVETAKEITKKEISMISQGLFIGNNEFSKPTHVEQIDHFHMRIVLTEGRYHEVKRLVSASGNKVIQLHRRRIGSYCLSEELRPGDWQLLSENDRKKITGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F284</accession>
    <name>I2F284_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">Theba_0307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730180.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0307"/>
    <dbReference type="EnsemblBacteria" id="AFK06037">
        <property type="protein sequence ID" value="AFK06037"/>
        <property type="gene ID" value="Theba_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0307"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="336" mass="35676" checksum="03B5DEF68FCCE78A" modified="2012-07-11" version="1">MKKGDLGIDLGTASLLVFQKGKGIVIDEPSVIAVEAKTGKIIAIGSDAKEMIGKTPKDIKAVRPIRDGVIADYQIIEQALKDLVKRTRTKFSFSRPAVVVGVPAKVTSVERRAVIEATTAAGASKVYLVLEPIAAAIGAGLHIFDSVGNMVVDIGGGTSDIAVISLGGIVVSRSLRTAGDAMDDAIIKFVKRKYKFLIGSSTAEDVKTKIGKAFPTLESFELEVRGRDALNGLPGNIRITSDDVHEAISQILQEIVLNLRQILEDTPPEIAADIMDTGVVLTGGGSLIRGLPDLIIQETGIKTVVAEDPRTCVVKGIGELLDCDKRLHRVAINHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2H3</accession>
    <name>I2F2H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA nucleotidyltransferase/poly(A) polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730245.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0398"/>
    <dbReference type="EnsemblBacteria" id="AFK06126">
        <property type="protein sequence ID" value="AFK06126"/>
        <property type="gene ID" value="Theba_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0398"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_5_0_0"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="373"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="864" mass="98904" checksum="2608E0F8B6BDFAE6" modified="2012-07-11" version="1" precursor="true">MKVITTHRNPDFDAFASAVAAQKIYPDHMIVFGGQLVPALKRFLSSKSLLLSFYYVNEIRISNLSSLIIVDTSDLKRIPASLQQSIQRNTDVKFYDHHRTSLSETQKGIFKDLGACTTLMCNQLRKKKKEISRNEATLFATAIYRETGNFTHASTRAQDLSTAAWLIDLGARPDDLGIYSGYKLSASQQRLIESLILGLRRTSIRGVEINIASARRDFLPGGLSLVVEKLWSFLGVENLVVLLETNNRVYYTLRSKYMNLDTAELDGVQRNSGGSYTLGYFENCTSAEAEEKIIKNFENNIERLIKVRDIMSSPVRTALAEMKVEDVFKIMQRTGHHTLPVVDQEKLVGIAKYRNTEKAIRHGLAARRIIEVMDRFFVTASVDDSVQAVTDKMIENDTTAILILDGGILSGIVTRTDLLKSTFGRRRIIDPGEKIGDQNYAKFPVEDLIEERVEKRIVTMLRFLGAVGSELNMPTYIVGGFVRDLLLNKKNLDLDIVVEGNANLFAETFKKYFNIKIVEHREFLASSMFFNDGLRIDVATARTEYYKKPAILPEVEMSTIKKDLYRRDFSINAMAIKLNQEDFGILIDFFGSRKDLSKGIIRALHPLSFIEDPTRILRAVRFEQRFGFEIEVRTAELLKQCAAEGYLDRVTGQRLRDELSKAIEEPLPLKALRRLASLGVMEKLFPETEFDRETDIRLQRYFLRRERNALLIGEDRMFYTLLMIILRKSDSKSVEWCIARYGLPKNYLERLNDAIATAGIIVNEKPETPSQFYRSLKTNKPEILNFVNSYLDEQEDLLFLAYLKKLNDTKLSINGNVLKTRYGMREGPEIRDVLDELFCARLDGLTKDKEDEFVREYLKGRGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2P0</accession>
    <name>I2F2P0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">Theba_0467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730307.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0467"/>
    <dbReference type="EnsemblBacteria" id="AFK06193">
        <property type="protein sequence ID" value="AFK06193"/>
        <property type="gene ID" value="Theba_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0467"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037303_1_0_0"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="454" mass="50702" checksum="C63207920208BA82" modified="2012-07-11" version="1">MLKYDFSFAFKETLESGLSFDEIFDIGKALSANFEKVFQPLPGFLRILDDDEILEEVGALKSWLQRFENFVVIGIGGSALGNQALHSSLKPINWNSLSNEKRGGKARIFLLDNVDPDLIASVLGELDLAHTVFNVISKSGTTAESMANYLVVRGLLEKLDLPVKEHFIFTTDKDNGVLRQIADNEGVRSLTIPDDVGGRFSVLTPVGLLSAVAEGIDIEQIYEGARFGKERYLRDDLKSNPAAVCALIHYAYLKKGHNISVMMPYSNRLYTLADWYRQLWAESLGKKFDLSGRIVHTGQTPVKSLGAIDQHSQVQLYNEGPKDKVVTLVKVEDFVNQLTIPFIHSDIEALSYLNGIGVGELLNAELRATSIALVANGVPNMTIIFPQIDEVHVGEFIISYEIQTAIMGFLLKVNPYDQPGVELGKKLTYALMGRKGYEEIRDRYEEKTSWRFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Q0</accession>
    <name>I2F2Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium ion-translocating decarboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730316.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0477"/>
    <dbReference type="EnsemblBacteria" id="AFK06203">
        <property type="protein sequence ID" value="AFK06203"/>
        <property type="gene ID" value="Theba_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0477"/>
    <dbReference type="eggNOG" id="COG1883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036168_0_0_0"/>
    <dbReference type="OrthoDB" id="662061at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="373" mass="38973" checksum="E27650FC91C8ADB8" modified="2012-07-11" version="1" precursor="true">MSTLISGYMAQTGLATVSWENWVMFAIAGLLVYLAVAKDAEPLLLVPIAFGMVIANIPPEATGVFTPGTGIMWILQQGLMLGIYPPLIFLGIGAVTDFSFVLANPKTLFLGAAAQIGIFITFLAANLMGFSLSDAAAISIIGGADGPTSIYVASILKSQFLPIIAIASYSYIALIPVLQPPIMKLLTTHKERAITMGKKLRRVSKLERIVFPVVATIAISLIVPQALPLVGMLMLGNLLRENGKTKRLVEASGKYISDTVIILLCVSVGAKADGKIFLTIESIMVLALGCAAFVVATASGILFAKLMNLFSANKVNPLIGAAGVSAVPTAARVAQKIASEEDPTNFVLMHAMGPNIAGVIGSAVAAGVFLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V2</accession>
    <name>I2F2V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730362.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0532"/>
    <dbReference type="EnsemblBacteria" id="AFK06255">
        <property type="protein sequence ID" value="AFK06255"/>
        <property type="gene ID" value="Theba_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0532"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125323_0_0_0"/>
    <dbReference type="OrthoDB" id="1776812at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="187" mass="20590" checksum="6978978CB96C0194" modified="2012-07-11" version="1" precursor="true">MGLRTICDHIIDIAQNAVDSGTEEATLRIVEKREESFYFSVVDRGKGISSESLESVLDPFYTEKRKKVKFGLGLPILKFAAESTGGEFRIRSVEGSGTEVSARFLLSSIDCQPVGDVPSTLFVVITLSGRVDWSIERLLDDEGYAFSSSQFREAFGNDCFTSPVKMKMVLTILQEAEISLGGLSDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2V7</accession>
    <name>I2F2V7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="10" type="ORF">Theba_0537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730365.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0537"/>
    <dbReference type="EnsemblBacteria" id="AFK06260">
        <property type="protein sequence ID" value="AFK06260"/>
        <property type="gene ID" value="Theba_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0537"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_0"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="9">
        <location>
            <begin position="8"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="523"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK06260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="808" mass="89477" checksum="1B5E96946E051E0D" modified="2012-07-11" version="1">MPEEIIHKNIDDELINSYMLYSMSVIVGRAIPDLRDGLKPVQRRILFGMSELGLHHNQGFKKSARIVGEVMGKFHPHGDAAIYDALVRMAQPFSMRYPLVEGQGNFGSIDRDPPAAMRYTEARMETLAEELLQDIDKNTVPMMPNFDGSLSEPDVLPTKIPNLLLNGTSGIAVGMMTSIPPHNLVEIIDAISLLIKDPECSVSDLLRHIKGPDFPTGGMIMDAASIPSIYQEGKGRITVRAIAEIEESGGSSQIVVSEIPYNTSKADIIEQIVNATQNHRDLQIRNIRDESDQKGLRVVIELKRGADPNVVLNLLFKHTQLQTTFSVNMLVIDEKKRPRVMNLKQILQGFLSHRFNVIRSKTEYDLEQASKRAHIVEGLTKATRSIDTVVDIIRNSANSEEASKNLMETLEVTQEQSSAILDMRMGKLTGMEIEKLLNEYKDLVAKINEYRMILASDEKVYGIILDELNEIKAKYGDARRTRIDLGNGTDFNIEDVIPDEDIVLMVTKKGYIKSTPLESYRKQGRGGKGVIGVRTGDEDFVVNILTTTRLSKTVIITSKGKAYVLSNHIIDHSSRDSKGKLLANYIKIDPDENVQAVLSTRKEEVQGKQLVITTRSGKIKKTEFEAFLNVRISGIKAISLNEGDRVIDASLTSREDDTIIISTKNGMVIRFPLDQVRSMGRSAAGVMGIRLKKNDEVVGANIVASEDTRFLLTATEKGGGKRTCLSEYRSQNRGGLGVKNIYGLEKIGKVIGTLVVNSDDEVILATKLGMSIRIPVSQVRPTGRVTKGVRIVDLKDNDIAASMAVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y0</accession>
    <name>I2F2Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Radical SAM protein, TIGR01212 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_0561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0561"/>
    <dbReference type="EnsemblBacteria" id="AFK06283">
        <property type="protein sequence ID" value="AFK06283"/>
        <property type="gene ID" value="Theba_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0561"/>
    <dbReference type="eggNOG" id="COG1242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060920_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="16"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK06283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="325" mass="36693" checksum="EDEC6FB6F4AB47A5" modified="2012-07-11" version="1">MSHKPYNDLKTHLKSRYGEPVQRVPLDAGFSCPHKVNGKGGCIYCDSSGSGFTVDSTLSLREQLESRMEFLRKKGIRKFMAYFQANSNTFAPVKKLRQLYREVIVDDVVILDISTRPDLVSDEVLDLLEEFTSDVDVILELGLQSINPNTIKTINRGHTLSHFIDSALRIKKRRIDLVVHMISNLPWDTEEDVAEAARLISVLGIDGVKLHSLYVVEGTELARMYEAGEVKIGSVDEFLERVVVFLEHLDWRVVVHRLVSDPPNEGTMFGNWGMSKIKLLNMLERKMIIEGRYQGSKALFYRSGSEKSDRGKSEESPDSMGRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Y5</accession>
    <name>I2F2Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">Theba_0569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492201.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0569"/>
    <dbReference type="EnsemblBacteria" id="AFK06288">
        <property type="protein sequence ID" value="AFK06288"/>
        <property type="gene ID" value="Theba_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0569"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_0"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="187"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="214"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK06288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="501" mass="55161" checksum="C44880563378555A" modified="2012-07-11" version="1">MDRIAVIDYGSQYTLLLARRIREMGVFCTVASPEEFKVESEIKGVVLSGGPQSVYEEGALGFPKQLEGFPVPIMGICYGMHLLAKKLGGEVRSGALGEYGLTNVSMDNERFRDIPEEIVTWMSHGDEVTSLPAECKVIARSKNGITAGFSNGRDIAFQFHPEVNHTQFGTNLIEDFVFNVCNASRNWKLSAFAERKVEEIKRIVGSSKVVGGLSGGVDSTVAAVLTSKAVGDAFTGIFVNHGLMRKNEDIEVCEALRSLGIKLINVDASEEFFRELKGIDNPEEKRKIIGKTFIKVFEREANKLNASFLLQGTIYSDVIESGAASKNSAKIKSHHNVGGLPDKMNLKLLEPIRELFKDEVRNLGYSLGIEPSLLTRQPFPGPGLGVRIIGEVDSEKARILKEVDSIFMDVLRKSGESEKIWQSFAVLLPVFSVGVKGDKRSYGYVVALRAVNSSEGMTASWHELPHEILREASSRITSGVREVGRVVFDITDKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I2F2Z9</accession>
    <name>I2F2Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease R</fullName>
            <shortName evidence="5">RNase R</shortName>
            <ecNumber evidence="5">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnr</name>
        <name evidence="8" type="ORF">Theba_0583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730391.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0583"/>
    <dbReference type="EnsemblBacteria" id="AFK06302">
        <property type="protein sequence ID" value="AFK06302"/>
        <property type="gene ID" value="Theba_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0583"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_4_1_0"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="627"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="737" mass="83707" checksum="1E432CC49C0145B2" modified="2012-07-11" version="1">MKLSLKALKEEMTSKDYSPTTMRGLIVKLGLTDREDRALLKKYLEELTDSGEIIKDLKGRYIVPGEKTIVGTIEFARRGTGAYISVEDEEDVFVAPEDSGFSIHGDTVLVEITGRYREIRKGKVIKVISRNKKKVVGTFKTRGIMAFVVADDMRIKTDFYIPPEGFNGAKPDEKVLIKITRYPSPGRNPEGVVEKVIGDVFSPEADLMTVIYRQDLPEPGYFPEQVRKQAARVAKSIDLQEVRKREDLRNELVFTIDGDDAKDFDDAISIRKSREGNYILGVHIADVSHYVREGTQLDLEAYSRGTSVYLLDTVIPMLPFELSNDICSLKPEEDRLTLSLLLEIDPVGRVVSSSVKNSVINSKKRLTYSEVNDFLNGEASSDISEKLRPVSESLKLSHELAQKIRDIRKKRGSVMDISSREVKIIFDEKGRVTDILPQSRGISEWIIEEFMILANETVAEIFNNQGLPFVYRIHDKPDPESMMQLKNYLEALGLKVKIPRNVHPKALQQILEKSKDHPLHSSIERVLVRGMKRAVYSDRNIGHFGLASEAYTHFTSPIRRYPDLVVHRLLKDLIKNAGADLKNHSKNLEESLSKIASWASKRERIANEAEWDLVDMKKVEYISNHVGDSFEGVITGVTKFGIFVELTEKMISGLVHISTLDDYYDFIEDQNILVGRRSKRVFRIGDQLEVKVVRADKTTMEIDFIIVNDNGKTTRRSKRSSPDKSKGKNSRSHKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F302</accession>
    <name>I2F302_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease HI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492223.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0586"/>
    <dbReference type="EnsemblBacteria" id="AFK06305">
        <property type="protein sequence ID" value="AFK06305"/>
        <property type="gene ID" value="Theba_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0586"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254710_0_0_0"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="25714" checksum="3E8FC3229CCEC13A" modified="2012-07-11" version="1">MTLNDWTLALKETGYEFARFLKKRGLCCSVTVISEYCVELSNSVVLRLYTNRKGNKRMVLPSFLSEEKSEWLLFRWEEFNGRNYDGVHLFVDGSFMDNKVGYGVLVITENQIEKRINGCLRENLEMKNVTGEIEGVIRALEYCMRKGYRKATIHYDYMGLRSWAEGEWKAKNKLTRKYVERLKQFSSQIDIEWVKARSHIGETFNEIADKLAKKAVEDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F316</accession>
    <name>I2F316_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492243.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0600"/>
    <dbReference type="EnsemblBacteria" id="AFK06319">
        <property type="protein sequence ID" value="AFK06319"/>
        <property type="gene ID" value="Theba_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0600"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_3_0"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="315" mass="34958" checksum="289F3EE01A5E9E69" modified="2012-07-11" version="1">MRRSGHTEIDASKLKALILDLDGTLLDNSKRIPASALNAIERLQEKGIKLAIFTGRDYLMAREYLDVLNIEGPHALQNGAFLAKGKGEIFLMRCIERKITEYSVSLASILNCHLLLRTDSSEIPDWYHVGDFALSPYLPFLESNINRIVRLDDLTEVVKSANLLQLDITGDLESLKEILGRLTSKYTGDFNFSFISASDDAGFLDVYWSQMEDTAVRLEIASKVDSWGLLSLFNASVSKGLSLDDFLNYHGLASQQVAFIGDHYADIPLLKRVGLSVAVENALPEVKAVCDYVTQSNNDDGVALAIEEIFFSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3A0</accession>
    <name>I2F3A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">Theba_0686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492354.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0686"/>
    <dbReference type="EnsemblBacteria" id="AFK06403">
        <property type="protein sequence ID" value="AFK06403"/>
        <property type="gene ID" value="Theba_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0686"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_2_0"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="101" mass="11240" checksum="AB94DB64EE928F03" modified="2012-07-11" version="1">MPRKTLVGTVVSDKMDKTIVVSVTRTHIHPFYGKTMKTTKKYHADDPEGLAGMGDTVEIEECKPLSKMKKFKLVKVLKKDVYTGEIPETPEAVEDSGGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3G4</accession>
    <name>I2F3G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730521.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0752"/>
    <dbReference type="EnsemblBacteria" id="AFK06467">
        <property type="protein sequence ID" value="AFK06467"/>
        <property type="gene ID" value="Theba_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0752"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1371655_0_0_0"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="198" mass="22760" checksum="9A9744065E9747F5" modified="2012-07-11" version="1">MGNRAHVLLFTLIAPFYEVAFKSQLKSYRRLLKEHRSLLGKGIRSVLDIGCGTGALALAFSELGYEVTAVDASAAMVMIARHNLRGSGVSVVQGDFFEKLPFEDSSFDLLVASYVTHGHKREGREKFYKESRRICNKEVLIHEFFPNRNPLISTVEFFERSDYRKFVPKAFEELKEYFPVVDRRRLSSSTGWYICRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3I1</accession>
    <name>I2F3I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_0770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730538.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0770"/>
    <dbReference type="EnsemblBacteria" id="AFK06484">
        <property type="protein sequence ID" value="AFK06484"/>
        <property type="gene ID" value="Theba_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0770"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="112"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK06484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="299" mass="34619" checksum="AFBF2B3328526CAB" modified="2012-07-11" version="1">MDFSEAVERFKENMEFVRNMSSNTVAAYLSDLHHFELFLNERGIDYKSVKRKDIELFVKEYSQGKYSRKRPSATTVARNLSTIRSFYTFLYISGTVSKVPTELIKNPKTRRRIPDYITHDEVMEILSSFRSTNLGKRNKAIVAIMYFCGLRVSEVCKLRLGDLRMGNSPAVRIMSGKGNRDREVPMNDQVLSIVKEYLQIRREFPMSEYEDHVFIGTRGEPMARNVIPKVLNTQVKYVYPEKRVHPHLFRHSFATQLLQKGASIKIVQELLGHANLSTTSIYLHITDKEKRAAVQLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3M3</accession>
    <name>I2F3M3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="8" type="ORF">Theba_0812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492510.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0812"/>
    <dbReference type="EnsemblBacteria" id="AFK06526">
        <property type="protein sequence ID" value="AFK06526"/>
        <property type="gene ID" value="Theba_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0812"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_0_0"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine binding" evidence="3">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="291" mass="33440" checksum="F7C2696BE380512C" modified="2012-07-11" version="1">MEDRELRTLNHLMYMEYYTGGNAGLFMKMKQLVYSFQSPFQRIDIFEHPEFGMVLVLDGITMFTEADEFMYHEMLVHVPLFTHPNPKRVLIIGGGDGGSLREVLKHPSVEEAILCEVDPYVIDAAKLHLKEMSVELDNPKASIFNENGADFVRKNKDYFDVIIVDSTDPTAGEGGHLFTKEFYSNCYKALRKDGIFCAETEDPFYDKGWVAIAYNRISSVFPISKMYTGFMTTYPSGMWTYTIGSKELDPLEDYDEERVLDFGAPLRYYNTEIHRASFALPTFLKELTGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3W8</accession>
    <name>I2F3W8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ORF">Theba_0912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492618.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0912"/>
    <dbReference type="EnsemblBacteria" id="AFK06621">
        <property type="protein sequence ID" value="AFK06621"/>
        <property type="gene ID" value="Theba_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0912"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_0_0"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK06621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="357" mass="39633" checksum="C48953B715C30FB2" modified="2012-07-11" version="1" precursor="true">MVMVMEMKIGIALSGGVDSAVAAARLIRQGNDVIGYHMIVLEGNPLANAAADDAKAVADHLGIELKIVDLREEFRRILNYFTTSYMSGETPNPCVVCNDSIKFGLLLERMFSFGEEKIATGHYARLVSLDENVFLARALDRAKDQSYFLSRIGKHKLHDILFPLGEMTKEEVRQEASGIDLPVHSKKDSQEICFIPDGDYRSFLKSRGIEGNPGPITDESGILLGRHTGLSGYTIGQRKGIGFSGRDRYYVKRLDLKNNKLILAQRQSLMSEALVAKDPNWYIDPGEEFDCLCKIRSSMKPVSAKVTIVSGEKIRVDFQEKVWAVTPGQLAVFYIDDLVVGSAFIEENCILESEGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3X6</accession>
    <name>I2F3X6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_0923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0923"/>
    <dbReference type="EnsemblBacteria" id="AFK06629">
        <property type="protein sequence ID" value="AFK06629"/>
        <property type="gene ID" value="Theba_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0923"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747346_0_0_0"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="41"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="360" mass="41098" checksum="32E362A7C8C5B7F9" modified="2012-07-11" version="1">MKKTKVAVIKTSPERVLDDYRRLAKLAGMKEAMDGSATTILKDNISWHLPMPGANSTPWQLEGAVLALKEEGFGEIVAVENKTVVTRPKYGEKQNKYDIIYEKYGIPILYNFEPENMSWVEYTPKSKLRILPKIYPEGLRLPDYFFGKNIVQLPTMKCHIYTTTTGAMKNAFGGLLNVKRHYTHSWIHETLVDLLKIQKEIHSGLFAFMDGTTAGNGPGPRTVIPVKTDYILASEDQVAIDAVAAKMMGFNPMDLKYIRLADEEELGNGRPENIELVGDDISGVDLKFHVGDNFASRVGDLLWFSPLKVFQKLFFHTPLVKIFVAASDTYHDKYWWKKHGVQIFEEWKKESPWGRLWESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z6</accession>
    <name>I2F3Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_0943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730670.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0943"/>
    <dbReference type="EnsemblBacteria" id="AFK06649">
        <property type="protein sequence ID" value="AFK06649"/>
        <property type="gene ID" value="Theba_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0943"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_1_0"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003658512" evidence="1">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="308" mass="34721" checksum="5FEB2E098A3EA8DE" modified="2012-07-11" version="1" precursor="true">MRVILKFTAIIVLLSISTALSATAEFDVQGHRGCRGLMPENTIAAFTHALKLGVDTIELDTVVTKDGVVVINHEAYLNPQRTRKDGQFIREKILIKDLTYEVLREFDIGRLSEPEDWPEQTQLDGQRVPSLEEVLSLVDEYNDSHGESVRVNIEIKHFPDRPSDTIDLKEHVHKVLEILLEKGFEELATIQSFNWEALKISKELEPSVQTAALVSKTNLDKSIWTAGLRLRNFGFDIGRMLASIGCSVISPSYSLMTDGWVESAHQSGLKIIPWTVNDLQEMERLIDLGVDGIITDYPDRLIELVSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F3Z8</accession>
    <name>I2F3Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_0945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730672.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_0945"/>
    <dbReference type="EnsemblBacteria" id="AFK06651">
        <property type="protein sequence ID" value="AFK06651"/>
        <property type="gene ID" value="Theba_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_0945"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="431" mass="47741" checksum="C90B9A8283C82A21" modified="2012-07-11" version="1" precursor="true">MKKLLVLVLLCLSVFAFGKTTINFWHAMSGSRLGAVDAIIEGFNAENPGIEVIAQFTGSYAETLTKAIASYRAGDQPHIVQVYEVGLQTMLDSNAIKPVFELSGPDFDWGDVIGPILDYYTVGDQLYSMPFNSSSAILYYNKDIFRAAGLDPNKPPSTFDELYEMGRTIVESGAAQGGISFGWPAWVFEQTHSVHGQFYANNENGRVGKATEVYFNDAFGVKVLAEWIKWAQAKVFMYGGREYDANQAFLTKQVAMLIQSTSSVSSIESKADFEMGTTFLPVMPGYPKGNSVIGGATLWVMKGHTDEEYEAIWKFFQYLMKTEVTAEWHKSTGYFPATNSAVKKLMDEGWFAENPNHLTAFLQILSGTRVPEAQGVRLGNFVAIRDIVDGAIENAIQYTGSDYEGEAKRILDDAAEKTNTTLEEYTLIYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F467</accession>
    <name>I2F467_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006492756.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1015"/>
    <dbReference type="EnsemblBacteria" id="AFK06720">
        <property type="protein sequence ID" value="AFK06720"/>
        <property type="gene ID" value="Theba_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1015"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_1_0"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK06720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="312" mass="33572" checksum="45F26E7EF4D58F5C" modified="2012-07-11" version="1" precursor="true">MNNIESFILSTLNATIRAGTPLLFAVLGTIFTERSGVMNLGLEGLMLVGAIGGFVASYQTSNLLAALLLAMLAGAILGLVHAFFTVTLRVNQIVSGLAITMLGTGISGLWGKDYIGVIARRFEPIKIPFLSDIPYIGQVLFNHDVLVYISFVLVPIMWFFIYKTKPGLTLRAVGESPEAADAKGINVFAVRYFYTVLGGSITAIGGAYLSLAYNSMWIENMTAGRGWIAIALVLFATWDPVKALIGAYLFGGITALGLRLQAVGAHISPDFLKMLPYLLTIVVLFFTSTDTLKRKVGAPASSGVPYSREERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4C4</accession>
    <name>I2F4C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalt transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_1072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730775.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1072"/>
    <dbReference type="EnsemblBacteria" id="AFK06777">
        <property type="protein sequence ID" value="AFK06777"/>
        <property type="gene ID" value="Theba_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1072"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK06777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="237" mass="26562" checksum="D13BD43B59F279D7" modified="2012-07-11" version="1">MSPESSDAILLLENLTVKVGDEEILSRFSLDVGPGERIALLGKNGSGKTTLLRVVAGLKKLESGRRMLNGRIGMVFQNPDTVLFGTTVRENLFFPLRLLSISMEESRRRIELFVTEFGFSNIVDRDILTLSGGQRQLVSLAAALISEPSLLLLDEPLSMLDRHDRDMILRTLEEVIPQRTSMLFATNRFSEVLNCERFIILGRKGKLFDGGYRELRNSFTVFEESGMSIPFEIAVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4G6</accession>
    <name>I2F4G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative toxin-antitoxin system toxin component, PIN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730815.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1114"/>
    <dbReference type="EnsemblBacteria" id="AFK06819">
        <property type="protein sequence ID" value="AFK06819"/>
        <property type="gene ID" value="Theba_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1114"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_3_0_0"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK06819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="145" mass="16197" checksum="13DF7EF4DE472A7E" modified="2012-07-11" version="1">MERVVLDTNVLISAIISSKGSPAKILDLWREGAFDLVFSEETLQELINVLSRRRMFRITGINEDELNRLVSYLRNSSIVVDSSEDISIAIEDPDDTKFISCAVQAGAKYIVSGDHHLLDVEKFEGTAIVTPAEFLRTFASFQNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4M5</accession>
    <name>I2F4M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S23 ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1180"/>
    <dbReference type="EnsemblBacteria" id="AFK06878">
        <property type="protein sequence ID" value="AFK06878"/>
        <property type="gene ID" value="Theba_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1180"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_0"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK06878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="118" mass="13771" checksum="F80F99CFAF9A7AAD" modified="2012-07-11" version="1">MEIYEVSMSFVERIYKLTRSFPEEERYCLVSQMRRAAVSVPSNIAEGNGRGHSKEYLHFLYNARGSLMELRTQIDISKRLGYLKEADYSSLIESYETLRKMLMNLISSIRRKSISKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4Q9</accession>
    <name>I2F4Q9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrA</name>
        <name evidence="16" type="ORF">Theba_1217</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730899.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1217"/>
    <dbReference type="EnsemblBacteria" id="AFK06912">
        <property type="protein sequence ID" value="AFK06912"/>
        <property type="gene ID" value="Theba_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1217"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_0"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="316"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="600"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="640"/>
            <end position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK06912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="945" mass="104921" checksum="44A979A0FE9DEA08" modified="2012-07-11" version="1">MDRYIYVKGARVHNLKNVNVAIPKNSLTIITGLSGSGKSSLALDTIYAEGQRRYLESLSTYARQFLGEMKKPDVENIEGLSPAIAIEQKTVSHNPRSTVGTVTEIHDYLRVLFARVGIPHCPSCGRVVQKQSLDEIVEGVLKEYGAEDRIAIYAPVANGKKGEFKKELEALRKKGFVRIEIDGETYDLDEDLKLDKNKRHTINLVVDRLRADADNASRLADSIEMALHEGDGFVEVGLVDSEERKIFSENFACPDCGISLPEISPKIFSFNNPFGACPKCHGLGYTMEFSKDLLVDESLSVLKGAIKTMSSNRDTFTLKMIVKVIESLGDDPAKPFKDLRDDVKNAILFGTDSDISMKYKSDRLTYELKRPYEGIINNLRRRYNETQSEDMRFWMESNFMVQQICTQCNGQRLRPEALAVTLGGLNIAQISDLTIQEIYDFMTGIYFTDFQREIVGELLSEIEKRLKFLVDVGLDYITLSRYAMTLSGGESQRIRLATQIGSGLTGVTYVLDEPTIGLHSRDNDRLIKTLKNLRDLGNTVIVVEHDEEVIRSSDYIVDVGPGAGVHGGEIVYQGTTQALLDNPPEGSLTGKYLNGDLSVPRFESANNSNGKFLTVKGAEKNNLKHIDVSFPLGKFITVTGVSGSGKSSLVMDTVYPSLKVALGASNSSSEKLAELIGWEEIDNVIVIDQNPIGRTPRSNPATYTGLFDHVRDLFAKTQEARARGYDKGRFSFNVKGGRCEACQGHGLIKIEMQFLPDVYVECDVCKGRRYNKETLEIRYRGKTISDILNMTVEEALTFFERIPTLKRILGLLNDVGLGYIRLGQPATTLSGGEAQRIKLASELKKTSTGRTFYILDEPTTGLHFDDVAKLVQVLKRLVEKGNTVVVVEHNMDVVKNADYIIDLGPEGGANGGEVVISGTPEEVAEYSHSHTGYYLKKQLSQLEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4S3</accession>
    <name>I2F4S3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ORF">Theba_1238</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730909.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1238"/>
    <dbReference type="EnsemblBacteria" id="AFK06926">
        <property type="protein sequence ID" value="AFK06926"/>
        <property type="gene ID" value="Theba_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1238"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_3_0"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFK06926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="569" mass="64226" checksum="68E0C606342A27EB" modified="2012-07-11" version="1">MFTKEELDEIKKSINIVDFIGRYVNLQKAGSSYRGLCPFHNDNDPSFYVHPQRGFFHCFGCGEKGDVISFYQKIENLSFAEAVKRLADYAGIPIQVDTAESEYDKFTTIMSRLAGIYNRELKEKRPETLAYLLEKRKISQNTIDEFQLGYSPDERTFPQSLPSKLRTDEKTLLQLGILVRRGATYSDRFAGRLMIPIDNESGKVVGFGGRIMDAEKGPKYINSSESKYFQKNRLLFNLSRARAAIKQLNYAVIAEGYFDVISLFEAGITNSVGLLGTALTERHLRILGNYTRNLLFFLDSDEAGQTASLRSIDIAEKLDFGTAVVFSRDQKDPADLFVAEGPKAIKETLALAIPGPAFRVEFFSRKLDLSIPLGRKHLIEHLKPYVISFRSTGNLAAVQSTIAALAQKTGYSERELESALRGGMSKSSGGEMKSGLALKLKDHIRIYLQHPKLRATVVKQIELMNESRDLKELLKGMKKGLELEELLDLVEESIGRELIELASTCIDFDTAQRVLQSTGLYANKRLVEEEMAEIDRRLPKVKDEGARKALLIRRIELRRMLERKMKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F4T8</accession>
    <name>I2F4T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK06941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730922.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1253"/>
    <dbReference type="EnsemblBacteria" id="AFK06941">
        <property type="protein sequence ID" value="AFK06941"/>
        <property type="gene ID" value="Theba_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1253"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577286_0_0_0"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="58"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK06941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="474" mass="52174" checksum="142D33216B38974F" modified="2012-07-11" version="1">MKDRSYEAVMARRKEIMKATVGVDYDRYELDGIAFDYERLMKDTSYPIASIRRIQSETGVGNTPLIELKNITRLVRSMSKSGYGARIFLKDEATNPSGSFKDRRASISVSRAKELGYKGVIAATSGNYGAAVASQSMKRALKCIVVQECYDSRGKGQPEILEKARACEAYGAEVAQLTVGPELFYYFLLLLEETGYFNASLYTPYAIAGIESLGYEIVEQSNTLIGRNPDYVLATHAGGGNLTGTARGLIKAGADQTKVIGVSVDLSGLHMASDRDFNRKSFTTGHTGFGIPFAVLPDRSDVPRNAARALRYMDRYLLVTQGEVFYVTEMLARLEGLQRGPAGNTSLTAAIALARELPEDKAIVVQETEYTGAGKLPSAQLTFARDNGVEIVRGDPIKMDSPGKRIAIPESYSQIAYKEVNMDDLRRSYIKQLMKQGVTLIDSDFEFLSAELKISATKVRELVKEVSDDVYSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F511</accession>
    <name>I2F511_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730981.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1326"/>
    <dbReference type="EnsemblBacteria" id="AFK07014">
        <property type="protein sequence ID" value="AFK07014"/>
        <property type="gene ID" value="Theba_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1326"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_0"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="296" mass="32655" checksum="FD2CA2B196F1C00A" modified="2012-07-11" version="1">MKNFVSAAIQFEAEPMNVKVNLQKAYHLIGNCKRETGASLVVLPESFTTGFTPIGNAESLWEVVDSIPGSLTDEAVRWAHEFDTYICFPTYERGKERAVIYNSAAIVGPEGMIGVYRKTHPFPTERLSAGGWTTPGSDPLVVSASIGKIGVVICYDGDFPELARVTALKGAEVICRPSAFLRTFDQWELTNRARAYDNHVYWIASNLVGKDSSGSNFFGSSMIVHPSGMKLAQASGCEEFVSAMLEADPIRKITPGASRDQIFDHIEDRNLDSYKGILSEGKSAFQPSKRIPYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F522</accession>
    <name>I2F522_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730985.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1337"/>
    <dbReference type="EnsemblBacteria" id="AFK07025">
        <property type="protein sequence ID" value="AFK07025"/>
        <property type="gene ID" value="Theba_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1337"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_0"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_3" evidence="5">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="167"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="392" mass="44604" checksum="6189C643701907B0" modified="2012-07-11" version="1">MLIARIKKGKEGKVLNSYPWIFKDEIMSLEGPTDKVCEVNVFSAGYEFLGKGFFSPFSSRAIMVLTNKDEELGEGFFGRLLSNALRKRERLFSRPFYRLVHGEGDRLPGLVIDRYGEIIAMQFRNLIIQQKREMILRLLRDIVKPNGIYERSDFEMGVDEKIERHTGLIFGEVPDSIEIEENGLKYLVDVKNSQKTGFFYDQRDSRTFCRKITEELSLKKGLDLFSFTGGFGLNMACSGADAICVDKSGDDLEQGRMNSVVNKLDNKLQFVQSDVLDFLAGFEKKDYFDIVVVDPPSFVKHRKELPHGISLFKRLVEGTLPLVKDGGVLGLCTCAYNIGIDHLVESVRRSTERTGITFSHLTITLQSPDHPWLVEVPESLYLKCLWGLVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>I2F536</accession>
    <name>I2F536_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">Theba_1351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014730987.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1351"/>
    <dbReference type="EnsemblBacteria" id="AFK07039">
        <property type="protein sequence ID" value="AFK07039"/>
        <property type="gene ID" value="Theba_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1351"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_0"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="346" mass="36867" checksum="0B257E5853E8BCD1" modified="2012-07-11" version="1">MSGVVRVGDVLIGGGNPITVQSMTNTKTSDVNKTVEQIKRLEDAGCDLVRVSVPDFESASVLKEITSLSRIPVIADIHFDYKLAVESIKNGAAKVRINPGNIGQDWKVKETVKIAKEYGVPIRVGANSGSLDKRFSSYEKPIALAESALAQVKILESAGFEDIVISLKSSSVIETVEANKYLYNKTDHPLHLGVTEAGFGLDSTVKSSIGIGTLLLNKIGDTIRVSMSGDPVQEIEVGLSILRSLKLRRGVDVISCPTCARTEIDVEALARKVNSWVGNTDADLSVAVMGCVVNGIGEGTEADIGIAGTASGGVIFVKGEIVEKVERADLEARFRHWFKTVLSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F552</accession>
    <name>I2F552_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731001.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1367"/>
    <dbReference type="EnsemblBacteria" id="AFK07055">
        <property type="protein sequence ID" value="AFK07055"/>
        <property type="gene ID" value="Theba_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1367"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_3_0"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="243" mass="25986" checksum="2C7866D3C7D6CE7F" modified="2012-07-11" version="1" precursor="true">MTFLQIVLIYLAGVAAGFMNVIAGGGSMVTLPLLMWIGIPPPVANATNRLGVLFESAIGMKTFHSSGIRLQKSIVPAIVFSTIGSVIGSMFVSSIPKDLLERVIALMLLAVAVLVLLKPGKPNISKPSQLLTALIFLGVGFYGGFLQAGVGFFLIGAITLTYGYDLVKTNFAKVVIVFVYTVFALVVFLSKGMIYWVPGLVLAAGNVIGAYFAVKLSIRKGSGFVRWILLTIVILNAVKYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F555</accession>
    <name>I2F555_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydro-lyase, Fe-S type, tartrate/fumarate subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731004.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1370"/>
    <dbReference type="EnsemblBacteria" id="AFK07058">
        <property type="protein sequence ID" value="AFK07058"/>
        <property type="gene ID" value="Theba_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1370"/>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_0_0_0"/>
    <dbReference type="OrthoDB" id="972093at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="272" mass="30108" checksum="EA3875C9520EFEB3" modified="2012-07-11" version="1">MIDENTIVNRIEEALVKANTILDNRARAFLNDYTGPFSAILRENAVISEESGLPLCQDTGFIEFFVFMGHEVVLERPISEILDRAVRNAYSSNPYRYSVVKDPLHHRENTGDNTPSVVHTFIRTGKRLEIRFLVKGGGSENLSRLFMLNPTTTQQELVDTIVHSVLENGARGCPPLKIGIGIGGSSEKSMILSKLALTREINVANPDPYYAMLEERLLREINNLGIGFQGLGKGITAYSVSIETAPTHIATLPVSLAVDCYLCRRGVVVFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5C2</accession>
    <name>I2F5C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-diphosphocytidyl-2-methyl-D-erythritol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731069.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1439"/>
    <dbReference type="EnsemblBacteria" id="AFK07125">
        <property type="protein sequence ID" value="AFK07125"/>
        <property type="gene ID" value="Theba_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1439"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_2_0"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070567">
        <property type="term" value="F:cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="228" mass="25167" checksum="5932F76F83D0AC11" modified="2012-07-11" version="1">MKTGAIIVAGGTGRRMKSSLPKQFMTLGGKEMFVRSVEIFHGSDFVYSTVLVVHRDWINKAKEILLKRGLNSVMVVPGGESRQESVYKGLLSCREVGLEAIMIHDAVRPFFSRSQIPELLRLVAPGRGVVVTEGVNDTVYLVGNDEVLDVPDRNCLRLAETPQTFPYDEMLEVHKRAVEENILSSTDDAQLFVRSGGQVITVNSIAPNPKITTAFDFDMAELLINKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5E7</accession>
    <name>I2F5E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Theba_1465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731084.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1465"/>
    <dbReference type="EnsemblBacteria" id="AFK07150">
        <property type="protein sequence ID" value="AFK07150"/>
        <property type="gene ID" value="Theba_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1465"/>
    <dbReference type="eggNOG" id="COG4258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352267_0_0_0"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="276"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFK07150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="803" mass="88694" checksum="623D34755F932199" modified="2012-07-11" version="1" precursor="true">MLRLSEFVIRHRVAVIVFFVILGAFGAYLSTKLNIDSDLLKILPKDNPVVKQYNRFISGDTSGDVTYIVLQTDDKTEKGIENLISAGRQIYETANEMKNIESFVRFDVMSDLGPLGLLMVDPAELSSMRSRDQDLSRTVQSLVNYDFSAVRSIGQMLVEFEELRGLLGNSPQSDEFWNFVRLPETIPTNDPMVLVMGIRLDGPSSDVSYVNRVIPLLRRWVGEICSSYGLSFGMAGDHFGTYDSNKQVNDDFMLTTIISLVGISLLFFFAYSSLKITLYVFFSLAISMFITLGISYVVFGSLNIITTFVTAITLGLGIDYGIHMITRLSDGASKQKNAVALLRDAYGALTRPLLASMITTALVFIILAAIDSPAIRELGILSSIGIVVFFVVMIVFLPALSIKTLINSTKVANIHLLDRFFQKISRVIIRFGVISGGVVFALILILSYLGLNNIRSFSYTPPGLMSPDSEQVAIPNLIERTFGGSIINTVPFILPDLDSLRKAHEEIDQNPNFKSSFSILSIVEGGKGDYMSQMEQVVREIDALRDSPLVEAVFKKANYYDFIVELLDRAGTVESSDDLISLVTEVIPESLRDQLLYLGGDEKTYFLLNSEPSSYIYRNNVIKIIYDSLSPELKETFGGYPKVFYYLMDLVRRVSLSICLVAFLAIFVVVAAERKSLIDGFKVLLLMIGILMSMFGLMELLGVDTTFVTVISAPLIIGIGVDGLVYVMHSSKRKGNSELSKTIKSVTMSSATTMLTFFSFVFAKGKLLSAFGISLGVGVLAALIVATFLVPVLPWNSREKIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5F5</accession>
    <name>I2F5F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate/oxaloacetate carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1475"/>
    <dbReference type="EnsemblBacteria" id="AFK07158">
        <property type="protein sequence ID" value="AFK07158"/>
        <property type="gene ID" value="Theba_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1475"/>
    <dbReference type="eggNOG" id="COG5016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_4_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="464" mass="51913" checksum="507E827A0A2C17B8" modified="2012-07-11" version="1">MRKVCFVDTTMRDAHQSLLATRVTTGELAEIAPLVDRVGYHAVEVWGGATFDSCVRYLNEDPWERLDILKESFKETKLQMLLRGQNLLGYRNYADDVVELFVRTMAKHGIDIVRIFDALNDFRNLEKSAKAVKESGMHLQIAMSYTTSPVHNVEYFVEISDKAVELGADSLCIKDMAGLLKPGTAWTLVSEIKKRHSIPLEVHSHFTTGIAGMTYLKSAEAGADILDTATSSMGFGTSQPGVESVWTALHDLGLADKPDYVLLKEINDYFVRVRKNHSETDAGFTINTSVLENQIPGGMYSNLINQLKAQNMSDRFEEVLEEVPRVRADLGYPPLVTPTSQIVGVQAVLNVMNNERYKTITKEVESYIKGFYGSPPAEIESTLKTRVMGDEKSISHRPGDTLEPEVEKGRNELGLLANSDEDLLIYLLLGEVGKRFLTQRYNDSLRVDFDVAKNFKEGITVYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H1</accession>
    <name>I2F5H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731104.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1492"/>
    <dbReference type="EnsemblBacteria" id="AFK07174">
        <property type="protein sequence ID" value="AFK07174"/>
        <property type="gene ID" value="Theba_1492"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1492"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_2_0"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="241"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="592" mass="66620" checksum="FBEE8E51FF71DBA5" modified="2012-07-11" version="1">MINSDDIRKWLVSSGVLNKVGKPSRYIGKELNRVIKDPDDKLRILLSFPDTYEVGMSHLGLKILYKELNKTDEFYAERAYLPWKDMIEEMIGARIPLYSMETYTAAAQFDIVGITLQYELCYSNVLALLELAGIPILQRERTTEPIVLGGGPCSTNPEPMADYFDAFVIGDGEAVTPQICIEVRENIELLRSGRRRELLELLSKIQGVYVPSLGRRKVVKAVIADLSDYEIDPSPLVPYMKTVHDRAVMEVLRGCNRGCRFCQAGMIYRPVRERGVDELRESVQKVLKATGYDELSFLSLSTMDHSSIDVLSEEILPLLEPQRVALSLPSTRIDSFGVKIASQIASIRKTGLTFAPEAGSQRLRNVINKNVSEDDLMATVKAAKNSGWQRVKLYFMVGLPTERDEDLEEIVRLARRVKAVGFKEVSVSAAIFIPKPHTPFQFSPQISEVEASRRLGILRKLSGRGIQLSCHDPSSSTVEGVLSRGDRKVGRAILRAYKSGAIFDEWNEEFDASIWQEAFKTEGVDVQNYMKGYSTQDELTWDHISLGISKRFFIEEYEKALREETTGDCRWVGCTGCAVCQTLNVTNVLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5H9</accession>
    <name>I2F5H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biotin carboxyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_1500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487061.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1500"/>
    <dbReference type="EnsemblBacteria" id="AFK07182">
        <property type="protein sequence ID" value="AFK07182"/>
        <property type="gene ID" value="Theba_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1500"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_5_4_0"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="141" mass="15170" checksum="1762E5086099E22C" modified="2012-07-11" version="1">MRRFIVRVNGKEYDVEIEELSSAAGSNPVSAAQKQETAQKVEAVERPRPTETVRDSEKPVEPEQQTSGSGRGINILSPMSGTILDVLVSVGDSVSPGQKVVMLEAMKMENSVLSEDAGTVKEIRVKKGDNIDAGEVMIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5I2</accession>
    <name>I2F5I2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Theba_1503</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1503"/>
    <dbReference type="EnsemblBacteria" id="AFK07185">
        <property type="protein sequence ID" value="AFK07185"/>
        <property type="gene ID" value="Theba_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1503"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_1_0"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="14">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK07185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="412" mass="46478" checksum="0DCFD2FC601BD2F9" modified="2012-07-11" version="1">MKGIPYVSHIDMDAFFASIEQAANPTLKGKPIAVTGIGKRHSVVTSASYEAKRFGVKSGMAFFEAVKLCPDLIAVGVQSKKYGYVSKEIMKMLTSVSPRVMVASVDEAYLDLSFHTRLEESINRFISFKRDLKERFGITASVGISVNPIISKIASDYSKPNGFVVVKDGMEREFLNEIPVKDVPGIGRHTLIKLESMGYRTTGELLKGLDDSPMDLYTMFGNAFMGFLQSLKNNRFSRKEFFKEERPKSVGHSMTLSGDISDFDLIVRVTNFLAARVIYRMGRYKMEGSGISLFLRYADRSSKALSKKLSFTISSIKDITEITPWLIRSIWNGTSVRAIGISCWALSEKKNQRQLSLFEKEKELLETVLEIEKKFGEYAIFPGNILFLPDIRKLEKPSDLHYQGFCRREVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5K6</accession>
    <name>I2F5K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731126.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1533"/>
    <dbReference type="EnsemblBacteria" id="AFK07209">
        <property type="protein sequence ID" value="AFK07209"/>
        <property type="gene ID" value="Theba_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1533"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344129_0_0_0"/>
    <dbReference type="OrthoDB" id="1124429at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="822" mass="93912" checksum="62F233497817417B" modified="2012-07-11" version="1" precursor="true">MFRRYFLITFLLLSAFLSGYSFRDLDWLKHESDHFVYLYHKEVASSIFQVEALAEDAFDTLSELFGNPFKEKITVIIGGYEDRSNGLANPVLESIYIMTVGMDYPYRNDGFWLEEVITHELTHLFQITSVTEFGNILRNYVSKAYLPNALQPMWLTEGFAQLGSELIGDLYEYDYRRLPFLLDQLMENEPFSEETVVTGFSGIGGESYYNYGYAFLSYLSETYGIESLLELVKVKRGLLGLTGIELAIKKVYGKSYEELKGEFIEYQIKKWEAAEVPFVYEFSRGVGEFVNHFRPKIYDGKLYYLSLDRQMKCYSLNIEGVEIFNSTMEIVDFAVFESEIALILFEEEQSETRLYFFREGKLERTKTAHLREIDYLGKDRLLVVRNNLGISSIEILSLRTERVTRIFTPLDPSTQIDNIRVSCDGSLIAFRINNKGDKSLAIYNSSTEKFGFFDVTNDFSIGGWVSEGFLISVKNEFGSDVYVVTSEGEMIGKSSFSRYVREPVMIADGVIAVGQLQGRKLLFSSNTKPTDYSLESKEIILSPPQEIEGVAYNGFSDWRFVSLLPFKGISVLFSDLTFRNKLLGGVSFDFETMLPGINVQLFSEDYLPVDFSLSLEYANLEPKALLNVYRRYRINPKLSFGWKASLEYPLRIAGSLDAALEDSSALYGGQASLNTLINVRDTQTATSNLVDVGINVDFDWNKHGFTIDSTIYSRVTFGEEPSIVPVELWGFRDDTNIVVGFSLDSDYVISRRGLNVMNLVHFSEEGIGGKIDFLIGSRFSWRIAIYKFETAFLYAAYPMHIKAGIMLENTRLLPYLDFELIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5L7</accession>
    <name>I2F5L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA helicase, Rad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731131.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1545"/>
    <dbReference type="EnsemblBacteria" id="AFK07220">
        <property type="protein sequence ID" value="AFK07220"/>
        <property type="gene ID" value="Theba_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1545"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_2_0_0"/>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="166"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="850" mass="97411" checksum="5AF55571C1DD3A0D" modified="2012-07-11" version="1">MGEILLGKVFKRNNEIKIGLRRLFESASFVSINIKDLPSFFSERDEDCLFIDASVEEVYLSEIAVDERFLNSFVYQPESRDLESRIDNYIRVIKKLPIGLSSLIEKIVPDRGLRNFLLFVLKQSENVDPWEDFLLSGLTRSERRESGNSRIDIKKAVRLVFSEGGLLQDSMEGYEFRQEQFMTALEIAESVEKGGNLMIEVGTGTGKSIAYLAPVAYACVSKMHQAVISTRTRILQDQLFKKDVEVLKTLPNLDNLRVSVIKGRERYLCVRKLFEVLNMALNKMLDESSSKELAGVILWSMFTREGDLDYLPLGDELRRMLSGNRFDCTRRLCPFFEVCPYYVQRENAKNSDIVITNHSFLFSEANIRLSDGEPEDGESIGTLLPAFKYLVVDEAHELESSLTQAMSYRFEPYQLANTIKKLIKLVRDCFGFLKRHFNEDFLRKLWIKLKEATTTLDRKIRQIVVDLDRERNGEKTTYSGKGLETLVSALTVISDILQTHIYVGGQTVQMLDDVEERDLKIDGLEFEVARVLAEIKEWLKQIAGIAASRDSRVVFVSRNEQCIESLSIVSSPVENDTLMSSIFPDVGVKIFISATLWVYSRGSDGFNYARRILGAGEETDAVRLGTSFDYTQQLRFFVPTDIPDYLPNSLPYMQSASKLTKDVLKIVGGGSMVLFTSYEDMKWTLSKIRGELHNLSLRIQERDDSLTTILSEHRNSEKSVIFGARAFWEGIDLPGEQLKLLIVYKLPFERPDEPLIEARIKHYGKRSFAEGMNKYYYPKMITAFRQGLGRLIRTRNDRGVVIVLDRRIIDPARVYSKKLIASLPPGTNIQAINSNQILRELRRLKKERWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5R8</accession>
    <name>I2F5R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superfamily II DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731170.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1607"/>
    <dbReference type="EnsemblBacteria" id="AFK07271">
        <property type="protein sequence ID" value="AFK07271"/>
        <property type="gene ID" value="Theba_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1607"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010261_0_0_0"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="287"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="504"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="1031" mass="117745" checksum="B2F77D21A65B5E7C" modified="2012-07-11" version="1" precursor="true">MNELEPLKTLLSSRVKHATTLGAKTIVLKNAKKETLKCISEGEFKTISNDVNLDFKWYQTIKSLKGLLSVADHFSDSPVVITEWLYVVIKKYAPLFESYFGKVVAVDCGERASIDTGENISDELMPLFDIDGQFISVKDFPETETIPLFERITPIEVNTLDQLLNHTAGKKCTGIHLDKNLESFLIEAGVSLVSSSSNHEVIIVSSPAESVQSEVDREVSMLRAIGREVEVIDFTGYCPGEEARSIDLKNELKEHFGFDSFKEYEVYGKTGNYLVSQEELIRYLIDQNYRQDPSDLFFVASTGSGKSLIYQLTAKILKRDLDRLTVVITPLKALMEDQVNGLIERYFENGAAFLNSDLSFDEKSELTQRVRKGEITILYVSPETFVGNSLSSIIGERSIGLLVVDEAHLVTTWGKTFRVDYGYLGEDLRFLRSRLSFPVMATTATAISGGELNTISEISKLLCLKNPKTVMTNVRRDNIKFKIDSFELNQHSKDCRTAQKLSDSIDYAIDLVESGKKSIIYCPFVGQAHNIYNAIADLEECRNKVGRYTGPTETQERRLTQELFRKGIYRTVIATKAFGMGVDIPDIDEVFHHSVPSIMADYVQEIGRAGRDGRPSVASTHFHTKDLSDSLKLSKISVPEQWKMRHIMEHIGTLIRQSKNGEIVLSLDDIRYLLITGKDKYNEETIRDKARVAIFLIQKDLENKTGKQILIRKGETYQYLYFTASNDDAEELMKSFPEISRESAGYSRKGFFHNEEIRSVGAVYKIDISALWARLYRDRNLRKLVWQFMRFPSKILGKPVIPKIAVEMSVIKDMDSIKQQLTRFIEILGEFALDSARKQMDEKSLFDGIISKVKSASLLTGVQDLDIKIRNIVKNNFVSYNGDRFQTGLFKCRGEIGNYIYTVQNIPNITKDRWLNKLEELLEPCEEGICRLYLNGQDEHTEVITSLLNILDILGMANVKFSGGESCAVHLKCTDRNYILNNFKNYYCEITRDIRRRIDREEQIMRDFFTMKLDDSQRWDFIENYFLGRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5T2</accession>
    <name>I2F5T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731184.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1621"/>
    <dbReference type="EnsemblBacteria" id="AFK07285">
        <property type="protein sequence ID" value="AFK07285"/>
        <property type="gene ID" value="Theba_1621"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1621"/>
    <dbReference type="eggNOG" id="COG1688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097416_0_0_0"/>
    <dbReference type="OrthoDB" id="1795039at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="231" mass="26082" checksum="9E9172C12C90F43F" modified="2012-07-11" version="1">MLVLQISIKGYTASFRSPASMNYQESLPFPPPTTITGIIGAATGREYFEAQNYCRDLSFGVHIQENEGIAKDAWAIKKVKDGGRSIGKAVVIREVLYQPNIRLLIVGPETKLKEIKKAISDPCFPLSLGRDDEFITFIQSELETAERVERSVIHNTVVKGDLQGKINITALNEGSIPHFKTYWLNSEFDRDKRNPKARRPKNRSPYTYISEPVEYSGEAVDVSDTVFPLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F5Y8</accession>
    <name>I2F5Y8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1681</name>
        <name evidence="3" type="ORF">Theba_1748</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MesG1.Ag.4.2</strain>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731236.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1681"/>
    <dbReference type="EnsemblBacteria" id="AFK07341">
        <property type="protein sequence ID" value="AFK07341"/>
        <property type="gene ID" value="Theba_1681"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07404">
        <property type="protein sequence ID" value="AFK07404"/>
        <property type="gene ID" value="Theba_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1681"/>
    <dbReference type="KEGG" id="mpg:Theba_1748"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_18_4_0"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="117" mass="13493" checksum="A1D27C4859B3CFF2" modified="2012-07-11" version="1">MEIQVATISVSSLERARVFYEEILGFEPDIFYEQTNWQSYKLDGTAGFGIIETPGLKRNRNSDILNFRITGVEELWNRIKDTVEIDTPLETTPYGILKFVIRDPDGFRIGFVEKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F603</accession>
    <name>I2F603_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_1696</name>
        <name evidence="4" type="ORF">Theba_1763</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
            <strain evidence="3">MesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1696"/>
    <dbReference type="EnsemblBacteria" id="AFK07356">
        <property type="protein sequence ID" value="AFK07356"/>
        <property type="gene ID" value="Theba_1696"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07419">
        <property type="protein sequence ID" value="AFK07419"/>
        <property type="gene ID" value="Theba_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1696"/>
    <dbReference type="KEGG" id="mpg:Theba_1763"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022176_3_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="395"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="521" mass="59032" checksum="BBD8761EA910F4C3" modified="2012-07-11" version="1">MTEKRSIKEIMKAYSEVPDKDFRQKLKILNELSQTMFKEGKPLLASETVKAELSRIEAPACIELANITHNMIKYSCVVGNYDASIEYALKAVDLFKEFGTADDVNDVIGNIGGVYVYMERFEESLEYTDKALEYARAIGDDLAVANFQNNKAVALKGLERFEEAMDCLNKAIEIKLSLRKKADLCNSYFNLSEVLISAERYDEVPAIFKKTEPLVKEIEDPAGSAEFDFLKAQYYMGTGNYAKALEKIESYIEYQKESGSMSKVPGALRNKIKIHEELGEEGLALETYRELDLLSQRTYKETCSARAAELAASFRFQQKMHEIQLLSNQNLELQEAKTTIEKQYEELLEIDSKLKKANELLEKQAEIDPLTGLLNQKKMYPIIEREINRATRYGTPLSMIMIDLDNFKNVNDTYGHLQGDILLKNVAGIIRSSLRKVDFVFRYGGEEFLVLLPSSDLQMASSTADRLRDELAKTTYPKVTMSAGVSSWSGEDATHFIQKTDHLLYAAKGKGKNRVEFQKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I2F678</accession>
    <name>I2F678_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_1779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
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            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07431">
        <property type="protein sequence ID" value="AFK07431"/>
        <property type="gene ID" value="Theba_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1779"/>
    <dbReference type="HOGENOM" id="CLU_3100647_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="51" mass="5566" checksum="F4093919DE3CE8B0" modified="2012-07-11" version="1">MTELGVFGVTIRCHPELVSGSGAPGMIHNYRVKDPNAGSQRSISQRQGCHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F695</accession>
    <name>I2F695_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multisubunit Na+/H+ antiporter, MnhF subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Theba_1797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731279.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1797"/>
    <dbReference type="EnsemblBacteria" id="AFK07448">
        <property type="protein sequence ID" value="AFK07448"/>
        <property type="gene ID" value="Theba_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1797"/>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_2_2_0"/>
    <dbReference type="OrthoDB" id="2083248at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="84" mass="9229" checksum="50015B99A60DA834" modified="2012-07-11" version="1" precursor="true">MIGFSIFFSLILIGAALTLYRLLRGPTVPDRVAALDILNVMITSAIVLFSLIDGNPLFLDIALVYAALSFLETIVVARYLEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6D3</accession>
    <name>I2F6D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006488378.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1835"/>
    <dbReference type="EnsemblBacteria" id="AFK07486">
        <property type="protein sequence ID" value="AFK07486"/>
        <property type="gene ID" value="Theba_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1835"/>
    <dbReference type="eggNOG" id="ENOG502ZWCP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330640_0_0_0"/>
    <dbReference type="OrthoDB" id="1959503at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="206" mass="23797" checksum="2FE8310E337F1BA1" modified="2012-07-11" version="1">MQRREWLERYRNDVLEQTCTGLEIDKSQLQDFILRMTGFLEESNIIADFGCHAQDFWPLLREMKLRVVGVSCSKAIKQTQGIRVMNIGFSDFNFLGIFEGFVASGILQNLHPELWSKTLLRIARSVKTSGVGLLVTGIGNEKESKKRCETLKKSGLPVVIGEYIDDDGNYNFRPLKSWYDQWLKNAGFYVLREEMIRDTVYSLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6G9</accession>
    <name>I2F6G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type cobalt transport system, permease component CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731328.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1872"/>
    <dbReference type="EnsemblBacteria" id="AFK07522">
        <property type="protein sequence ID" value="AFK07522"/>
        <property type="gene ID" value="Theba_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1872"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_2_0"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="261" mass="28828" checksum="982F073650025E1C" modified="2012-07-11" version="1">MVEIPLGRFFPADSIIHKLSPVVKTISFVALAVGSLFLSGIVDSLILFSFWISLLLLSKVPLGEYIKTLWTIKFLLLLIVIFQLFFTHGKVLLDMKILRITEEGLLNATLLTVRMVFAVFFSITLSYTTTPMEISSSIEAIVGKLPMKTKRVSELGMALSLTLTFIPLLSLQTNRIIMAQKARGVEFNGGSFFKRVRNSLSVVIPVITTSLKKAQDTASALEIMGYEPGHTLRSLDKMSWSINDSIILISTAVSITAVVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6I3</accession>
    <name>I2F6I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_1888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731338.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1888"/>
    <dbReference type="EnsemblBacteria" id="AFK07536">
        <property type="protein sequence ID" value="AFK07536"/>
        <property type="gene ID" value="Theba_1888"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1888"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_4_1_0"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK07536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="228" mass="25332" checksum="909E1782B9A9FAE5" modified="2012-07-11" version="1">MPNAFFVLPEDNRVILDGGETKHLRVTRAKPGDELTGIDGRGTVYRFLLEELGKSSASGTVVEREYVERDGKSITVAVAATKWPRLHILIEKATELGVDRIELFNSLRSVSRVDETKLTKFNAVAREAAKQSVNPYIPEITVSQTLPLEGSYNLLLEFGGRPLLEVEEKLACERKLRLIVGPEGGFAPEEIKDISTRCTPVSLGRRTLRVETSVIVVLGIINYRLGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6R1</accession>
    <name>I2F6R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_1971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731406.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1971"/>
    <dbReference type="EnsemblBacteria" id="AFK07614">
        <property type="protein sequence ID" value="AFK07614"/>
        <property type="gene ID" value="Theba_1971"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1971"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_3_0_0"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657791" description="Dipeptidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="521" mass="58963" checksum="A23FF0189B9F64C6" modified="2012-07-11" version="1" precursor="true">MKKLLLTAILIVSLFYVSAVACTDILAAKQATLDGSVITSHTCDGRYDSRLVVVPAMDHEEGAMAPVYEWIVYADRMDLVKLGEIPQVAHTYQYFNVAYPMANEHQLIIGETTLGGARETANSDKAIMTIEQLEIFALQRTTNARDAIKLIGALAEEYGYRESCWLGECITISDPNEVWVFEVYGTGPLWEPGMGPGAVWAAQRVPDDHITTVVNYSMIGEIDLETNRPPNVSAGDFMISEDYVQVATDLGLYDPASGEPFVWKYIFGDIEGTKSDRLWRVFSVLNPSGNWSLDNTWEYPFSVKPDEKVSVYDIIELYRDVSEGTPYDMGDNEAWYYESGGEMVKSPLASSEPNTPMRNLLGIPYTRTIAKNGCSYYFVSQARDWMPDKIGGLLWFGLDNPRKGAWIPVYVGTLPNTLPESWVTLNRDELDRSCSYWAFDLVDKISNQRLGALMPLIEEVRVPFQTEMFEEQRDLDEMAMTLYEDNPELVLRLLSSYTARKMREAEELWYDLSEVLLTKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6T5</accession>
    <name>I2F6T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_1995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731427.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_1995"/>
    <dbReference type="EnsemblBacteria" id="AFK07638">
        <property type="protein sequence ID" value="AFK07638"/>
        <property type="gene ID" value="Theba_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_1995"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_7_0_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="431" mass="48653" checksum="7D51E7E4C5ADB557" modified="2012-07-11" version="1" precursor="true">MKKIFFVVFLVLMLSVTVTAKLVYWHTQEEESRQQVIAQIIESFTIETGIEVDVVAIEENEMFSRLAAASAAETLPDLIEAGAETILGLGADGLLDTAIPTRFIKNGGDFYNGATRFVITPTGDEYFAVPYHGWVQGIWYRKDWFEKAGLAEPTTWEAIMEAAKYFHDPQNGMYGIVLGKANDAYAEQVFTIFALSNGARIFDKEGNVIVNSPEMKEVLQYYKDLGEYSAPGHTYWQQARELFLAGKTPMMFYSTYVMDDLALAEIQTQYISDFDPELVENTEFAPMMTHSRSSSFGQVLSLAVVKSSENKLDVLKFLDFVFEPDNYIKYIHMAPGGMLPTRSSIAESEEFLNDPKGIYRRYGADKIKAIIYGMENIEKFGYVEGRVFPEMGKISGAFTIGNGIVMMFDNDATPDQVLTFWREDIRKLIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Y8</accession>
    <name>I2F6Y8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase T</fullName>
            <ecNumber evidence="5">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aminotripeptidase</fullName>
            <shortName evidence="5">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepT</name>
        <name evidence="9" type="ORF">Theba_2050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2050"/>
    <dbReference type="EnsemblBacteria" id="AFK07691">
        <property type="protein sequence ID" value="AFK07691"/>
        <property type="gene ID" value="Theba_2050"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2050"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053676_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="208"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFK07691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="46229" checksum="0D8DAB49D8F07820" modified="2012-07-11" version="1">MIEKLIERFLRYISIETTSSFESKTFPSTTGQLDLARTLKEDMESIGLSEVTIDDFGYVMGTLPSNLETKLPVIGFISHMDTSPEMSGKDVRPSIVKYQGGKLLLNKKDNLYIDPHLYPEIERYVGEDLIVTDGTTLLGADDKAGIAEILTAMEFIISNPRIKHGKIRVAFTPDEEIGRGTNHFSIEEFGADYAYTVDGGGIGELQYETFNAANTEVVIKGLNIHPGSAKDKMKNSMLIACEFNGMLPSNEIPATTCGREGFFHLISVQGSVEETILKYIIRDHSREKFSRKKTMISEVAALLNYKYGENTVTFCTEDSYYNMKEKIEEVYFVVETAKRAMESLSIEPKIEPVRGGTDGVRLSFVGLPTPNLFTGGHNFHGRFEYIPIRSMEKSVQVITKIVELFSEEATFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F6Z3</accession>
    <name>I2F6Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07696">
        <property type="protein sequence ID" value="AFK07696"/>
        <property type="gene ID" value="Theba_2057"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2057"/>
    <dbReference type="HOGENOM" id="CLU_639051_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="429" mass="49962" checksum="AA983C27671EBA20" modified="2012-07-11" version="1">MFFKKINDRRRENRITKIERRISKSREEEKGRLLYELWNLKRGKGDNEGAMKAALERLAFLKDPESFEDLISTFEKIDGSSKNSFAREIEKFACEFDRGLWEEFISVFFEDQPEAAIKFALSCYRISSKALFAEIALKKLENAVYNEEPDRLVRLREMYISTISEVGEISRVEQLRLLERALDSSKSLIQDEQLLSNLAVKYIDLMLSGEDLDGIAKKLSGSFDRFVVYFKGNEVTLLDKLDLILPKIEEEEIKRALIEKLRILGQSISDKRYDSDFSGESDYLEFLKKSIANYEFKARKRDSGEEILRKLASDYERIIDILESPEEKLLYIRKLGALLRDRLEEPYKALEVFEEGLRLKADDISLWLVKGMTLEKIARNESDPVKASICWKRTYNHYHAIAETFEEQEVKLTAIEKCATIQAERLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F733</accession>
    <name>I2F733_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731512.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2102"/>
    <dbReference type="EnsemblBacteria" id="AFK07736">
        <property type="protein sequence ID" value="AFK07736"/>
        <property type="gene ID" value="Theba_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2102"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_0"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="337" mass="37669" checksum="87C1A13B753AC057" modified="2012-07-11" version="1">MANMKDVAKRAGVSVATVSNVMSGKKYVSPELKRVVLESIDALQYRPSKIARSLKIRKSFLVGLLVPDITNPYFAEIARGVESIALEHDYQMFLCNSDGRSYREEETLISFLGHGVDGVINVAPRMDEELLADLSNGMPMVILDRHLKIENPLIDVVYTNNFKGSAQLARHLLDKGHKRFACISGPKDVPSAVRRLQGFCSELEKDGIKGENLKIYFGGFKYEDGFKIMKQYILKLKIRPTAVFAGNDMMAWGAIEAAKQNGLKIPEDIAIAGFDNVLYSSLVIPSMTTVDQPKYEAGRTAMKLLLEKIIKKQHGEYVDTRKIELDSHLIVRESTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F755</accession>
    <name>I2F755_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731527.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2124"/>
    <dbReference type="EnsemblBacteria" id="AFK07758">
        <property type="protein sequence ID" value="AFK07758"/>
        <property type="gene ID" value="Theba_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2124"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_6_0"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="170"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK07758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="544" mass="59619" checksum="D0C0D66A5FAD20D8" modified="2012-07-11" version="1" precursor="true">MRLIKVLTLITALFVVLCFSLTGCIKPEVYYSLSGQVVPYFPETSAHDSFQRTAAYTPIFSSKDIEQGFMSNQFIVLFDRGFDSTIISGVSGVEILDEFFSRDGSVGYAVVKTNDPSSLSGIEGVKSVEPEKIFTLQSEESVPNDPLYSGQWNYPMIQMPQAWTIAKGSSTVVVAVIDSGARLDHPDLEGIFLPGYDLINDDDDPTDYDPVKSHGTHVTGTIAAKTNNSLGVSGMTWGEYCTIMPIKIFEAGETTAGILASSIIFAVEHGAKIINMSLAGGDDDVVAAAVKYAKENEVLMIAASGNKPYQRYPALYDEVISVGAVDNDMRWASYSNYGVYLDLVAPGGSSSAQILSTGYSTDEGNTYSYMQGTSMAAPHVTGLAALLMAKGYAGKDDSGEEIIRKILRETALDLGESGWDEYYGFGLVQAYDSLTYEEERRPLLVQILSTSGEVIRETEVNPDGSFQFNGLTENYIKIRVWRDFNGNEEIDKGDLIGYYGYQESDHYLVWNPSLDNAETLSYLSSGSYELTNPLHFFPIIEFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B2</accession>
    <name>I2F7B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2182"/>
    <dbReference type="EnsemblBacteria" id="AFK07815">
        <property type="protein sequence ID" value="AFK07815"/>
        <property type="gene ID" value="Theba_2182"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2182"/>
    <dbReference type="HOGENOM" id="CLU_3397371_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="31" mass="3485" checksum="32186FBEE1A160B9" modified="2012-07-11" version="1" precursor="true">MLEIIQVYFMVMSGGFSRSVGECYLVEPVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B6</accession>
    <name>I2F7B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Theba_2186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006487704.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2186"/>
    <dbReference type="EnsemblBacteria" id="AFK07819">
        <property type="protein sequence ID" value="AFK07819"/>
        <property type="gene ID" value="Theba_2186"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2186"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFK07819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="267" mass="29340" checksum="AC96C5BB0245CF91" modified="2012-07-11" version="1" precursor="true">MNKRRINLWIGTVLISILMLMMVVSLFYTPFPVTEINRLERFEPPSARHLLGTDNFGRDVLSRIMKGSQTAFFVGLVAVSIGSVFGVLIGAISGYFGGIVDEIIMRIVDAMMAFPSILLALMFVSVFGVGLRNTIIAIGIMSIPSFARITRSGFVQHKELDYVKNAKIKGISNLRIMFRHILPNVLSPIVVAASMGFANAVLAEAALSYLGLGIQPPNPSWGRMLSESQVFITVSPWYAIAPGIFITLLVLGFNFLGDGIRDIRENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7B9</accession>
    <name>I2F7B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731586.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2189"/>
    <dbReference type="EnsemblBacteria" id="AFK07822">
        <property type="protein sequence ID" value="AFK07822"/>
        <property type="gene ID" value="Theba_2189"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2189"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_3_0"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657676" evidence="1">
        <location>
            <begin position="20"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="362" mass="40492" checksum="8F803DAE6DCE5C88" modified="2012-07-11" version="1" precursor="true">MIRKIATLAVIVVMSSVSLVSNPINDVINRIIDFEGFWGAILVSRGDVILHAGGYGMADIERTIPNTPEKKFRIASIKKQFTAAAILRLCEDGLMSLSDPVGKFIPEFQNGDIISIEQMLNHSSGIPTMINTQELREEIRKFEVGRTLQEAEIAYISSLPLRFEPGSSFLYSNSAYFLLSVIVERASGKRYDEYLRTSFFEPLGMNNTGYDYNEYDSGWGLPYYCDSYVIDLSSVRPADWVDRRLPGGAGGLYSTVYDLYLWDRALSAGEVLSESFLRLMQSPSNELFEAGYGVFIGNELIDGEYRRVVYHDGDTKGTSTRINRYVDDDIFVVVLSNIEGKDFTALAHELAKAVIVNDMGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7D6</accession>
    <name>I2F7D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2207"/>
    <dbReference type="EnsemblBacteria" id="AFK07839">
        <property type="protein sequence ID" value="AFK07839"/>
        <property type="gene ID" value="Theba_2207"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2207"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082411_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="294" mass="32708" checksum="A80364F7CD0ED02A" modified="2012-07-11" version="1">MVLIEAALVAVPSVFFTDDGRAVQRILNVLEDAQEEVILVSYSLDETEIIKCLNHLERRGVRIEVMIDDSTVDRAFAKSPEFEIRSDTAAALVHSKFLVVDRQVIVFGTGNFTEGSLREDSNSFLVFESPSVAELFLRYFEAIETGVSLDEVNIGNIDFYLCPSQEARKRVIKELMGARREICFAMFAFTDPEILAALKFCASIGVRVTGIVDSWNEDSPLREYLTSGMEVDEGGAVTIHDKTFVVDGETVITGSANASLSGWGKNREVVAIIDSRELAKEFVNHFEYIRGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7E5</accession>
    <name>I2F7E5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Theba_2217</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731608.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2217"/>
    <dbReference type="EnsemblBacteria" id="AFK07848">
        <property type="protein sequence ID" value="AFK07848"/>
        <property type="gene ID" value="Theba_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2217"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_0"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="357"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFK07848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="472" mass="51994" checksum="DFFBA1E28AA664D8" modified="2012-07-11" version="1">MRKTKIVCTIGPATESLEVLRSLLQRGMDVARLNTTHGDISEHRERIRNLKEIRKSANSPLTILLDLSGPKIRTGVFKKDAVDIKRGSEIILTTEDIEGDEKIFGVNYKKLPEEVQPGNLILMDDGKIKLRVESITGSEVRTKVLNGGIVTHRRGINLPGIDISIPAITEKDKKFIKLGIEERVDYFALSFVRRSEDVVHAKKVIKDLGGSIPIISKIETEQALKNIEQIAEVSDGLMVARGDLGVEIPVEEVPVAQKKIIRHGNQKRIPVITATQMLESMIENPVPTRAEATDITNAILDGSDAIMLSGETSIGKYPLEAVSVMDLTARAAEKYLKQNPELLKWTREKISTDDHTDAICRAAWDISEELKVKVIVSSTFSGHTARNVSGFRPRAHILAVTPNEETYYRLNLVWGARPVLMGLGSSTDDLVRVAGPLARRLKLVKSGDTIILTAGIPFGTSNSTNILKLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7I7</accession>
    <name>I2F7I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731649.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2261"/>
    <dbReference type="EnsemblBacteria" id="AFK07890">
        <property type="protein sequence ID" value="AFK07890"/>
        <property type="gene ID" value="Theba_2261"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2261"/>
    <dbReference type="eggNOG" id="ENOG502ZY4Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129665_1_0_0"/>
    <dbReference type="OrthoDB" id="1542309at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024227">
        <property type="entry name" value="DUF3795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12675">
        <property type="entry name" value="DUF3795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="148" mass="17398" checksum="15F99A0511463574" modified="2012-07-11" version="1">MEEALIAPCGMNCSLCINYQSMKEDLKKKGFRRQYCPGCIPRGENCTHMGDQCELLAKGSVRFCFECKAFPCKRLKALDKRYRTKYHMSMIENLEFIRDNSIDLFLKKEEEKWRCPECGGVICCHNGLCLNCNLDTLRKNKKYRWNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7P4</accession>
    <name>I2F7P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2320"/>
    <dbReference type="EnsemblBacteria" id="AFK07947">
        <property type="protein sequence ID" value="AFK07947"/>
        <property type="gene ID" value="Theba_2320"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2320"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1967950_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="127" mass="14990" checksum="996F265152638C41" modified="2012-07-11" version="1">MRNCPGPEKCPYGGYIIYASEDPQYSDLMYECSIYKEFRRVRENMERLIKVLPKGLWERRLDNFIPEDEVTERALDLSKKYVRHRAWKIGSNFVLLGGYGTGKTHRFCLFFCVNPFFVMGLRISLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q0</accession>
    <name>I2F7Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Preprotein translocase subunit SecB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731704.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2327"/>
    <dbReference type="EnsemblBacteria" id="AFK07953">
        <property type="protein sequence ID" value="AFK07953"/>
        <property type="gene ID" value="Theba_2327"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2327"/>
    <dbReference type="HOGENOM" id="CLU_1842760_0_0_0"/>
    <dbReference type="OrthoDB" id="2020103at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003708">
        <property type="entry name" value="SecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035958">
        <property type="entry name" value="SecB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02556">
        <property type="entry name" value="SecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54611">
        <property type="entry name" value="SSF54611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK07953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="139" mass="15604" checksum="95B5A8B881F566E9" modified="2012-07-11" version="1">MNRVEQAILQMKRYLIKEFCFSYTPVQNEIVISIELGRETKIIEEDGKKNCLLELTLTAFGRADETDYLTIKASMEGVFECQETLEEKALEKMVAESGTSILLPVLRAAILSFTGQAGLTPPIVIPLMNPRFSSEAEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q3</accession>
    <name>I2F7Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Preprotein translocase subunit SecB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2330"/>
    <dbReference type="EnsemblBacteria" id="AFK07956">
        <property type="protein sequence ID" value="AFK07956"/>
        <property type="gene ID" value="Theba_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2330"/>
    <dbReference type="eggNOG" id="ENOG5031384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712424_0_0_0"/>
    <dbReference type="OrthoDB" id="1904068at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035958">
        <property type="entry name" value="SecB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54611">
        <property type="entry name" value="SSF54611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="150" mass="16777" checksum="ACE19C55BBB7D5F7" modified="2012-07-11" version="1">MPEPVNAEFRFLAHRISDFSFTLHEGIKNMSVSLDLDDPELEYRRADNGCLLGLLSLSVKVRGRSGRKIALKLDATIKGRFEAPENMEDKTFEDFCMISGAATLIPLLRATIISFTSQAGMNPPIRIPLINVPQSLSKTALSEKREKNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Q6</accession>
    <name>I2F7Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK07959">
        <property type="protein sequence ID" value="AFK07959"/>
        <property type="gene ID" value="Theba_2333"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2333"/>
    <dbReference type="HOGENOM" id="CLU_2844791_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK07959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="65" mass="7281" checksum="2B35CF6EFCA80496" modified="2012-07-11" version="1">MTESGLFAITINCHPKLVWGSGPEEPRTWMRSVATKNRSSPKDGSMLFDEGPRTALCSVQRVIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7R1</accession>
    <name>I2F7R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731714.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2339"/>
    <dbReference type="EnsemblBacteria" id="AFK07964">
        <property type="protein sequence ID" value="AFK07964"/>
        <property type="gene ID" value="Theba_2339"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2339"/>
    <dbReference type="eggNOG" id="COG1794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055360_1_0_0"/>
    <dbReference type="OrthoDB" id="1359310at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK07964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="229" mass="25273" checksum="BBEAA701B90F0A6F" modified="2012-07-11" version="1">MKRIGLLGGMSWESSLEYYRLLNEMVKNRLGGLHSAECIMASVDFGPVSDMMKMDDWKGIERVLSEAAQDLKRAGADFLIICTNTMHLIAREIEKASGLEVIEIGIAVGEEIERRGLKTVGLLGTKFTMERAYYRDTLAGFGISVIVPSEEERAVVDRIIFEELCKGIFKEESKSAYKKIISGLQMNGAEGVILGCTEIPLLIKESDVDIPVFDTTAIHARAAVEHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7S5</accession>
    <name>I2F7S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731726.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2354"/>
    <dbReference type="EnsemblBacteria" id="AFK07978">
        <property type="protein sequence ID" value="AFK07978"/>
        <property type="gene ID" value="Theba_2354"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2354"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="376"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK07978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="565" mass="64128" checksum="31F3E231640CF42B" modified="2012-07-11" version="1" precursor="true">MKNPALKVALLYVVFGVIWILFSDMIVDLMFVEKDLVAHAQTYKGWAFVIFSGILFYFLIYREFSEKNKTQLELVKQKDLSDAVLDTVGVFVAVLDSEGVIVFTNETFEEILSLKSEDIIGKNCSEVFASPDLANWIENTASKTLDREIENFYEADLETSSTTLHIRWALSNLTSWRGEHDYFVLTGVDITQLVESERSATHRLANIRALHEIDMAVSYHLELEKMLDVFLERLISRLGVDGADVFLIDEERSVLRFAHGKGIVTGEMDFRELPMEGTIPSSVASSGKPYSGPLDTSSNPECPRLKNLIDMKVKDYHAVPLETRGKILGVLETFDMMQIHRDSEWNDFLQMLAAQASLAIDVALMIDNLKDSNRKIAEAYDQTLEVLVGTLEMRDMNTKKHSRRVADLTVWLAEKMGASEEEIENMYRGALLHDIGKISIPDSVLLKEGPLSEDEWKVMKTHPTTAYEVLSQVEYLRPSLDIPYCHHERWDGSGYPRGLKGEEIPLAARIFAVVDVYDALTSDRPYRKAWSKEKTVEYLLENSGKLFDPAVIEKFLEILRVSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7T1</accession>
    <name>I2F7T1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="10" type="ORF">Theba_2361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006490028.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2361"/>
    <dbReference type="EnsemblBacteria" id="AFK07984">
        <property type="protein sequence ID" value="AFK07984"/>
        <property type="gene ID" value="Theba_2361"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2361"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_0"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFK07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="305" mass="33544" checksum="FEA48F31F79DA9D4" modified="2012-07-11" version="1" precursor="true">MDVVGKFGRILIPMSTAFAADYSIDYPMTRRIASYLISKNYCDSLVIAGTNGEFYSMSFEEKVRLFAEVKQEVGERVPLIAGTGTANTHETIELTKEAARLGYDAAMVVVPYYCHPTQEGIYYHFSQICKNTDLPIMVYNIPLFTASNIDPSTLAKLTEFENIVAVKDEAGINPLQTSAFLKATEGKIVVYSGDDLMVLSVMSQGGIGVISGGSHVIGDMMRNLIEEFLSGDATKATGSFKELYSLFSAFFGRNRRLVNPLPAVKKAFALHSGLDVARVRPPLMEIEEDEVAVLKDTLRKFGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7U7</accession>
    <name>I2F7U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2380"/>
    <dbReference type="EnsemblBacteria" id="AFK08000">
        <property type="protein sequence ID" value="AFK08000"/>
        <property type="gene ID" value="Theba_2380"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2380"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_2_2_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="220" mass="24721" checksum="DF8709BFA468B5B4" modified="2012-07-11" version="1">MNYDFYIGKFEVTFEEYEAFCDETGRILPDDSGWGKGARPVMNVSWWDAIAYCNWFSNKQGIPLAYDSEGNLLDGRGKRTTDPSKVEGFRLPTDAEWEFAARGGNTSEGYTRLVGNSVDLVAWYKSNSENLTHPVGTKAPNELGIFDLLGNVWEWVSDYHTDYSCSEEANPYVDSFSAYRVKRGGSWIDCPVGVSIDVRSKGLPDHAITNLGFRISRTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7X8</accession>
    <name>I2F7X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731771.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2415"/>
    <dbReference type="EnsemblBacteria" id="AFK08031">
        <property type="protein sequence ID" value="AFK08031"/>
        <property type="gene ID" value="Theba_2415"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2415"/>
    <dbReference type="eggNOG" id="COG3889">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_1_0_0"/>
    <dbReference type="OrthoDB" id="63045at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003657688" evidence="1">
        <location>
            <begin position="23"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="79"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="833" mass="92614" checksum="CD3F8B387BA5C29B" modified="2012-07-11" version="1" precursor="true">MSKRLTVILLASMIVLCGGVFATEKGPISDVIYFNVKMSQELGLRDVAEGLTDIFMEGVSGPTLMGMDKATRDKMDIYSVPALTYALFVNPYPNEAPYFANVDGKDFFNVMAINEFRYALNDLINRQYIVDEILGGAGGPMLSMATPGQPGTYRYGLVANKLGLSFEGNETRALEAMKKALEDAAKIPENQGRLVNSNGKWYFDNEPLTVKFVIRADDPNVRVKMAEYVSLQLEKAGVTVDRLVWERSKASNTAYGSDPADLIWNLYTEAWSAGATRAFWEHIVRQMYASGGSYMPGRGTEGFWNFRNEKLDDLIDRAYTGNFLTEEEYWDLSLTALEMGLKDAVRIYVCYQDGFYTANSARLLDRFAYGLGDGVNDWSLKTAVTDDKVLFVTQYSSVGALFMSNWDPVGPDGISDTYSANVVTILSDPSSFESPASAINTPYRVNWTHDDIVTKVERNSEGDVVGTIDVPENAIRFDSKTKQWKEVGPGVKSMSMGTYTLLGGNMHQGQPITVNDYLYAFAFIDEWISRDGENDKYYEASYENYMRSGQDTIKGYIVNDDGTITTYFDYNFPASVDRTAQWGAPFLGVHRQPFVIVSWEIYEALAEIVANGSQSGTVYAFRNDPAVTQIDVLVPNHVKDIKAKLVELIEKGHVPNSLKGLITVEEAQSRYQAAIDFIDKYGHAYISNGPYYLSKYDPTANYAECRAFRDPSYPYEPYYWKEMLKTVRLSIDSIDVPAIIMKGMDTTVKVVVAEVAYPSEEVSKASRGSVVVTLITPEKEMTFDAVLIEPGLFEAVINAEAIEDLEPGSYNVLAIASLEGAVPASSVTSTIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I2F7Z6</accession>
    <name>I2F7Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptide epimerase</fullName>
            <ecNumber evidence="5">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2436"/>
    <dbReference type="EnsemblBacteria" id="AFK08049">
        <property type="protein sequence ID" value="AFK08049"/>
        <property type="gene ID" value="Theba_2436"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2436"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="344" mass="38073" checksum="56780C9F7F35A15E" modified="2012-07-11" version="1">MKIKDLRFTEKKWDFVKPFHIANNVSTSKVNIEVELVLSDGTVGLGESSSSFRVNGESEAAIFQLQKEILEMIKDLDVRDYRKVFAKLDAYSRTAPSLKAAIQFATLHAFSRSISTPVYQILGGMKDFVETDKTVSIGSLEETVHDAKEIFDAGHKVIKMKVGEDVKSDVARVLAVNDEIKGVRYVIDANTGYTTKEALRFIDAMYRNDVPVGIFEQPVPAEDFEGLKIIRQGSMYPVGADESAKTKYDVMRLIKEGAVDYVNIKLMKSGLSDALAIVEMCNSAGIGLMIGCMSESGIGVSQSVHFAAGTGAFTYHDLDSHLLLKDVDPVGFRQEKDRQYPILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I2F810</accession>
    <name>I2F810_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08063">
        <property type="protein sequence ID" value="AFK08063"/>
        <property type="gene ID" value="Theba_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2451"/>
    <dbReference type="HOGENOM" id="CLU_2617911_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="78" mass="8812" checksum="94311FC61DEA5740" modified="2012-07-11" version="1">MRYAVIAVSSLERQYKGIKTKMKNEGKDVTEMNAEMKEAAIRLLENLAAIDEYSLTDQDKASLGDIVEAALEMFINKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F826</accession>
    <name>I2F826_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic glycine betaine/choline-binding (Lipo)protein of an ABC-type transport system (Osmoprotectant binding protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2468"/>
    <dbReference type="EnsemblBacteria" id="AFK08079">
        <property type="protein sequence ID" value="AFK08079"/>
        <property type="gene ID" value="Theba_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2468"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038355_1_1_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="2">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="301" mass="32508" checksum="BF338ED6898F2AF5" modified="2012-07-11" version="1" precursor="true">MKRLILIGLLFIAFSGFALKGPITVASKIDTEGALLGQMIVTVLEKNGFEVVDKTEFGTTSVIRKAITAGEIDIYPEYTGNGGFFFDDTDPTVWKNAKSGYETVKTLDLERNGLVWLTPAPANNTWALAIRKDISDGEGIKTLEDLANYVNGGGFIKLAASEEFLTRADAMPAFQEAYGFELSNDQLLAFSGGNTAQTIRAAAQSIDGVNLAMAYGTDGALSALRLVVLEDTKGVQPVYEPAPIVRKEIFEMYPEIGELLKPVFESLDLETLQSLNASIAIEGLDAGDVAEQYLKSKSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I2F830</accession>
    <name>I2F830_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2472"/>
    <dbReference type="EnsemblBacteria" id="AFK08083">
        <property type="protein sequence ID" value="AFK08083"/>
        <property type="gene ID" value="Theba_2472"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2472"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2650250_0_0_0"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="76" mass="8479" checksum="35B0BE6D0586B7D7" modified="2012-07-11" version="1">MQLRKLSRQRFVEVPHSVIPDLIRDLVLILSEDGGALTDNAVFISHQRVFALKRSAVLLFAIWNGLLATALLRTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I2F856</accession>
    <name>I2F856_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Theba_2501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731841.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2501"/>
    <dbReference type="EnsemblBacteria" id="AFK08109">
        <property type="protein sequence ID" value="AFK08109"/>
        <property type="gene ID" value="Theba_2501"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2501"/>
    <dbReference type="eggNOG" id="COG2964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1650141_0_0_0"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_6" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_22" evidence="2">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFK08109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="160" mass="18371" checksum="E5371C983A3999FD" modified="2012-07-11" version="1">MILAKNGFISGDVYGDLAKYKSSYLEGDFINHLAVHKSGKFIKSTTFHLKGEDYHYALGINYDFTYMREFSNVLENFMKVESDLQSAISEAGENKLSSIFDSCLEAVGKPIERMNKSDRLRLISLLKREKAFDFSKAVPYVSSRLNLSRYTIYKYIKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F861</accession>
    <name>I2F861_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicilin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731846.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2506"/>
    <dbReference type="EnsemblBacteria" id="AFK08114">
        <property type="protein sequence ID" value="AFK08114"/>
        <property type="gene ID" value="Theba_2506"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2506"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665353_0_0_0"/>
    <dbReference type="OrthoDB" id="186419at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="413" mass="46355" checksum="8A96B07B0D1EEBC5" modified="2012-07-11" version="1" precursor="true">MRKQMTLWMVLISIIVLLSILPVRIFAGQIEIVRDSWGVAHIYADNDSELFFGAGYATAGDRTFQMELSRRKVAGTLSEIYGKDLLESDKLMRTLGLYKHAQELPDVQNPFSGLVASASHLSVRDWYPYSLTIGTGETGHNPRSIRLYEPLDDQNEFTFESFSEIHRDNVSAIARDFLSLAGILSEKNLLSQNSTRLLKALSHWDYRLLKNSRAADVAETVVREMHRSLRPNTVTALVASKYGGCHSGNIFLLRSALEEFERTQKLPEEEELAVWVNQLLEASAGSLREAVSQVRKVVMVYQTNLEGLPSIYPDANRKAPDLVTTSGNTIWSQLGNSYTQIVDLSNIDKCRAFLTPGASEGPRSPHFFDQVELWVTGETRPASLSREEVTKYVESIETLFSPINKTMRQSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I2F880</accession>
    <name>I2F880_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731858.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2529"/>
    <dbReference type="EnsemblBacteria" id="AFK08133">
        <property type="protein sequence ID" value="AFK08133"/>
        <property type="gene ID" value="Theba_2529"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2529"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_443927_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="420"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="620" mass="70086" checksum="8515630222E53540" modified="2012-07-11" version="1">MEQCILDIKELSSNDTGNVNLKEINLEVNSSEVHALVGEYGAGKELVVNVLTGAEKKISGRVFFDGIDVTNKIKIGGSTDIMFLLEEPMVAEGLTVAENMYMLRSHSNVIKLINHSKINHTVKELIARFDLGISEKTHVYKLSTEEKKLIELLRLCIYEPRLVVLYEPTANLSSKSQDLLLRILTELKEKGTGILYVTNKWDEAMKYSDRISVLSEGVLCGTLSSEEAKDKPEKLLRLILGWKKSDSIKRETEEIETEDIIDAVLRAAEYLTSNYEINDVLKMLENYTCKIMESDSCYVYLVDEKTRTIMDTIKHKETELVEAALNDEVVMRIMDNKKLFVSNFDDVLFEKLFKSIRNTETIVCDPVSVRSHHTALFQVGYRKFYEPTEKQKKIFHTLSRQVALAIDNTRLMGSSVLLQESHHRIKNNLQTIVSLINIQKRSLDRKTGSEVEDLLDNVVSRVKSIAAVHDLLSHDELGRSIINLKSLVDTIVRFNIVDGTLQVRKDLDDIFIPYDKASGISLTISELINNCVKHAFKDLENGLISISCKSFDDNVEIIVEDNGTGFPNRSFSEKDEKLGLSLARSIVENQFDGTLEISSEKGARVKILIPKESLLLTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I2F882</accession>
    <name>I2F882_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ureidoglycolate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Theba_2531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-ureidoglycolate = glyoxylate + urea</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731860.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2531"/>
    <dbReference type="EnsemblBacteria" id="AFK08135">
        <property type="protein sequence ID" value="AFK08135"/>
        <property type="gene ID" value="Theba_2531"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2531"/>
    <dbReference type="eggNOG" id="COG3194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298556_0_0_0"/>
    <dbReference type="OrthoDB" id="1597997at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="212" mass="24247" checksum="823D7E04BD49FAA3" modified="2012-07-11" version="1">MAVVDVKLEKLSEVSMRDFSTFGRIIGRDEDTEEGKYELHPVDAKPAVENSMIKAYWDLIPFKDNKEDRFSMGMLFVYPKPIGEVLNWTEVHYETYEFFFPLGGKQFIFVLAPKSKIPEAEKTRAFLIGPNEGVLLNKGTWHYPPFAIDGPTPVLMPRFGKLGEVTGDVTEAYGKKWETPVGNRYFKGQLHALKTDYYGEGYGGEYKIRIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I2F899</accession>
    <name>I2F899_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Theba_2552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731877.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFK08152">
        <property type="protein sequence ID" value="AFK08152"/>
        <property type="gene ID" value="Theba_2552"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2552"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_0"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFK08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="411" mass="48579" checksum="771DCFB30CDA5F67" modified="2012-07-11" version="1">MRSYEIPKKVVLEAFKKVKENRGAEGIDEVSLEEFEADLDNNLYKIWNRMTSGSYFPPPVKAIEIEKKSGGKRVLGIPTVGDRVAQMVAKIYLNPLVDPYFHKDSYGYREGKSAIDALEVTRQRCWRYDWVLEFDIKGLFDNIDHELLMRAVKKHVKIPWLILYIGRWLKAPFMQANGRVEERSKGTPQGGVISPVLANLFMHYAFDKWMERTHPDKPFARYADDGVIHCRTLEEARLLLESLKERMEECKLELHPEKTRIVYCKDDKRKGEYPNTSFDFLGYTFRVRSCKARNGRIFYSFTPAVSEQAKKAMRQKIRRMRLQTKSYLSIEELSERINPVIRGWINYYGHFRRFEMYTVLSRLNKALVQWVRNKYKKRRGRTKAGKWLETLARREPRLFVHWTMGIFYSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8F3</accession>
    <name>I2F8F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="5" type="ORF">Theba_2606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731916.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2606"/>
    <dbReference type="EnsemblBacteria" id="AFK08206">
        <property type="protein sequence ID" value="AFK08206"/>
        <property type="gene ID" value="Theba_2606"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2606"/>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_0"/>
    <dbReference type="OrthoDB" id="1100044at2"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFK08206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="302" mass="32704" checksum="24BAB93611386875" modified="2012-07-11" version="1">MKFDQLETERSNPRTRNLDELSTYEMLRIMNEEDATVPLSVREVLNEVASAVELCVRSLEMGGRIVYAGAGTSGRLGVLDAAEVVPTFGVSKDLFVTMIAGGQEALANAVEQAEDSIELGEEEAKKVDITEKDAVVGISASGRTPYVEGILKYARKQGARTILICNVGTPRLTELADVTIAVRTGPEVITGSTRLKAGTAQKMVLNMISTITMVKVGRVFGNYMIGVKILNRKLVDRATRIVSEISELSYEESEKILEASGREVPLAILMALTGLGKEKCEESLKRNRGHVRSALKELGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8G9</accession>
    <name>I2F8G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-galactosidase/beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731930.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2622"/>
    <dbReference type="EnsemblBacteria" id="AFK08222">
        <property type="protein sequence ID" value="AFK08222"/>
        <property type="gene ID" value="Theba_2622"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2622"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345744_0_0_0"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="256"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="817" mass="94972" checksum="3525A54C495468E0" modified="2012-07-11" version="1">MRRRIDLGGDWLFEILENEPDDVGKIEPTKTIEIPGCVERTYPEVTSSQRYLYFEREFEYERNSDCSTILAFGAVDYLCKVFLNGSRLGSHRGGYLPFEFDISGVLSSRNRLQVLVFDPIDDRKINFRLIPHGKQNGDPNWYTNISGIWQGVWIEERPPVHICRLRVDTSYLKRSLEVAFTTNEEFDRACIGVFDKSDRLLASKRSVDKSISLSLPSCLPWSPETPSLYRLVVTLESGKSRDVIERRVGFRDFVAENGKLFLNGRDFYMKAVLDQDFYPQTLYTIPSEEFLRESFAKLKKIGINTIRHHVKVPDPKYMDIADEVGLIVWQDAPHFDLFSDEGSEELLELIDGAVRRDSHHPSLCLYSIINESWGINQTDPRQVKWLIEAYERFKERFPGIVWIDNSACVGNYHLKSDLNDYHFYVSSIDRQDKWNSLIELYSESPKSFYKGEHKNNAEGRPLVVSEFGNWSLPPEIWLRKKEKPYWFNHMFNDVPMTKPEGALERFDNSEISKEYSYRELFELSVENQEENLNIEIDKMRLHENIRGFVITELSDVFWECNGLLDFDRNFKIDPERMRAILDNDLFVSLLDKEELWIGEEVNLRIFLLKDIKRETLRIKIGEEIREMPLSGEKGDTVRVSLETDKFSEGLLKIEILLDKCVATLHAVLSRKDIAEITIINNPHFGLQKPLDRKSVVMLDRPGASFEYNGYKASTVAKDDLLSGDWITGIFWNSKLLSDVFPGGLFRRCHRSLIEDRPMISSSGYSRRLSGVVYGWLTDFYGYIDMVDDSIYLSTLHLDPKRPLANLLLRRLSDLHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8H4</accession>
    <name>I2F8H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Theba_2627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2627"/>
    <dbReference type="EnsemblBacteria" id="AFK08227">
        <property type="protein sequence ID" value="AFK08227"/>
        <property type="gene ID" value="Theba_2627"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2627"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_1_0_0"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFK08227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="438" mass="49075" checksum="A7B746CB542A3B15" modified="2012-07-11" version="1">MDKCRIDPRVFKVPIDKMRAGYYSDKYFTRLVEVLKKADKKSRVLYQLFPRRDATIVGIDEALAILRFGTGYYSNEGEAKRLFEEVLEIEKAVNHAAWEMDRHALVELTAQKWDLKMMLNDLWVDKWPELEVRALYDGDEAKDMEPVMTIEGDPRYFSYLETILLGVIARASSTATAVKSVVKAARGKEILFFSARFDHFWTQATDGYAALKAGAFGVSTDANADYWGVESMGTIPHALIAVYNGDTAEAALAFDRYIEGGVNRIILVDWDNDVIGTTVDCVARTYKAETGEDFTPGRTDPSVVIGPGKGKIWGVRFDTSGSLRDVSVVPKDASSLGVCPELVWRARREFDRYGMKDLKIVVSGGFTADKIDLFEKLNVPVDVYGVGSSLLKNKLDFTADIVEVEGRPCAKVGRGKIETPRLEKVASDYWNNDKEERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8J2</accession>
    <name>I2F8J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Theba_2645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731951.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2645"/>
    <dbReference type="EnsemblBacteria" id="AFK08245">
        <property type="protein sequence ID" value="AFK08245"/>
        <property type="gene ID" value="Theba_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2645"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668634_0_0_0"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="222"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFK08245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="424" mass="48386" checksum="9820545058CCFF30" modified="2012-07-11" version="1">MTVKSKITLLYLFTYGSIVVSLGLTVFFVLRNLEMRRIDNLLISFHNDIVNTYKYAGEENRLLTLAGDEDLGFAIYTDEVPIASFRAEPEFFKAVTGSGTKGDYRFRSSFEIIEGKEEKFVTFYDLDESQKYLRFVFVTIVIFSLLTLLIVSVVGMVFTRKLINPFEEAGNQLERISRSGLKNSRVELRKTGEEVSKLEREINKSLIRIEQLIEDAKQMSSKIAHELRTPLAVMKTNLQLSLTKDFSEDTMREALKSTLGEVDKLIRLSEDYLLLSRTESSLPIEKNLINFSQLLLQTIEKILMIHSDKDLEIDIAPDIVIRGSGYMLEHVIINLLDNACRYTTDGSVEVKLISDEHGSFLSISNMGKAIDFVQNEELEEAKQIKGYGLGLRVVRSILRAHGLKLEYTHLDGKNIFVIDFPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P1</accession>
    <name>I2F8P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrS</name>
        <name evidence="12" type="ORF">Theba_2695</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731988.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2695"/>
    <dbReference type="EnsemblBacteria" id="AFK08294">
        <property type="protein sequence ID" value="AFK08294"/>
        <property type="gene ID" value="Theba_2695"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2695"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_0"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="275"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="9">
        <location>
            <begin position="249"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFK08294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="648" mass="74677" checksum="06AF8CE5BCFFBD31" modified="2012-07-11" version="1">MAISIKLPDGSIKEYESGITPAEIAKGISEGLARRAFGAIVDEELWDLERPIEKDASVKLVLDKDPESSRFFRHTMSHILAQAIMRLYGKEKVKLAIGPTIENGFYYDIDLGETRITEEDLPKIESEMSKIIKEDLPVERFELPVSEAIELMKREDQPYKVQLIEDLVKDTGAEKVTFYKQGEFVDLCRGPHVSSTGKVKYFKLTSVSGAYWRGDENNKMLQRVYGTAFAKKSDLEDYLRMIEEAKKRDHRKLGPALGLFTINYEYAPGMPVFLPKGTEMLNQLLQFSREKHVEDGYREVSTPQIMSDALWRTSGHWDHYRDNMYFTEKEDQQFAVKPMNCPGHIIVYKSSSVSYRDLPMKLFEFGKVHRYERSGVLHGLFRVRGFVQDDAHIFCTREQIQQEIMGVIDFVQKIYSPFNFEYRAELSTRPEDYMGEVELWDIATKALEDSLLAKKMEFKVNEGDGAFYGPKIDYHIKDSLGREWQCATIQLDFMMPERFGIKYVGPDNEEYQPVMIHRAIFGSVERFMGILIEHFAGAFPAWLAPTQVSVIPIADRHAEYAESVAAELKSRGFRVEVDDRQKSTNYKIREAQLMKVPYMIIVGDREKEDGTISVRLRSEKDLGSIALQEFMDKLSQEVNMRSATSIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-07-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I2F8P5</accession>
    <name>I2F8P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Theba_2699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mesotoga prima MesG1.Ag.4.2</name>
        <dbReference type="NCBI Taxonomy" id="660470"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Thermotogae</taxon>
            <taxon>Kosmotogales</taxon>
            <taxon>Kosmotogaceae</taxon>
            <taxon>Mesotoga</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol. Evol." volume="4" first="700" last="708">
            <title>Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.</title>
            <authorList>
                <person name="Zhaxybayeva O."/>
                <person name="Swithers K.S."/>
                <person name="Foght J."/>
                <person name="Green A.G."/>
                <person name="Bruce D."/>
                <person name="Detter C."/>
                <person name="Han S."/>
                <person name="Teshima H."/>
                <person name="Han J."/>
                <person name="Woyke T."/>
                <person name="Pitluck S."/>
                <person name="Nolan M."/>
                <person name="Ivanova N."/>
                <person name="Pati A."/>
                <person name="Land M.L."/>
                <person name="Dlutek M."/>
                <person name="Doolittle W.F."/>
                <person name="Noll K.M."/>
                <person name="Nesbo C.L."/>
            </authorList>
            <dbReference type="PubMed" id="22798451"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">mesG1.Ag.4.2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003532">
        <property type="protein sequence ID" value="AFK08298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014731992.1">
        <property type="nucleotide sequence ID" value="NC_017934.1"/>
    </dbReference>
    <dbReference type="STRING" id="660470.Theba_2699"/>
    <dbReference type="EnsemblBacteria" id="AFK08298">
        <property type="protein sequence ID" value="AFK08298"/>
        <property type="gene ID" value="Theba_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="mpg:Theba_2699"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000002881">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFK08298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002881"/>
        </source>
    </evidence>
    <sequence length="436" mass="48590" checksum="3EBD33F3A68C5546" modified="2012-07-11" version="1" precursor="true">MKKFLLVSVVLMFSLILSATTIQFWHAMGGWRIDFLQSQADAFMELHPDIEVEVQYTGSYRDTLNKMIAAVQAGTAPHVVQVFEIGTQMMIDGEVAIPIEEMMEADPTFDIGKFMPQVLNYYRVNGKLYSMPFNSSNAIVFYNKSLFEKAGLDPHDPPTTFEDFIEVARKLTIKDSAGNVEQAGFTVSLNSWFFEQLLAAQDAPLIDQNNGRTGRPTKAVFNTPEGLAIFEWWNTMSQEGTMINTKFEDWTAARNLFISQKAAMLMTSTSDVALMMESAETNGFELGSVFLPRPSDSKAGGAIIGGGSLWLIDGHPDEETKAAWEFIKFMASTEQQIEWHKATGYFPVRKDSVEKLVASGYYGDYPDHLTALLQLLLSVQSYNTNGAITGAFPEIRTVVTTAIEKMIAKEMTPSEALKYAEDGATQAIRDYNEANY</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>